Fabrication of a Polymeric Inhibitor of Proximal Metabolic Enzymes in Hypoxia for Synergistic Inhibition of Cancer Cell Proliferation, Survival, and Migration

Yuki Koba, Masahiko Nakamoto, Michiya Matsusaki

ACS Applied Materials & Interfaces　2022/11/14　Research paper (scientific journal)

Biomacromolecule-Fueled Transient Volume Phase Transition of a Hydrogel

Masahiko Nakamoto, Shiro Kitano, Michiya Matsusaki

Angewandte Chemie International Edition　2022/04　Research paper (scientific journal)

Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-γ-glutamate and calcium cations

Masahiko Nakamoto, Moe Noguchi, Akihiro Nishiguchi, Joao F. Mano, Michiya Matsusaki, Mitsuru Akashi

Materials Today Bio　Vol. 14　p. 100225-100225　2022/02　Research paper (scientific journal)

Development of Highly Sensitive Molecular Blocks at Cancer Microenvironment for Rapid Cancer Cell Death

Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki

Langmuir　2021/11/18　Research paper (scientific journal)

A Biomimetic of Endogenous Tissue Inhibitors of Metalloproteinases: Inhibition Mechanism and Contribution of Composition, Polymer Size, and Shape to the Inhibitory Effect

Masahiko Nakamoto, Teresa Escalante, José M Gutiérrez, Kenneth J. Shea

Nano Letters　Vol. 21　No. 13　p. 5663-5670　2021/07/14　Research paper (scientific journal)

Combining Acid- and Base-Imprinted Nanoparticles in a Hydrogel Film for Temperature-Responsive Quick and Reversible Capture of Salt

Yu Hoshino, Mitsunori Moribe, Naoki Gondo, Toshiki Jibiki, Masahiko Nakamoto, Benshuai Guo, Rinoka Adachi, Yoshiko Miura

ACS Applied Polymer Materials　Vol. 2　No. 2　p. 505-514　2020/02/14　Research paper (scientific journal)

Abiotic Mimic of Endogenous Tissue Inhibitors of Metalloproteinases: Engineering Synthetic Polymer Nanoparticles for Use as a Broad-Spectrum Metalloproteinase Inhibitor

Masahiko Nakamoto, Di Zhao, Olivia Rose Benice, Shih-Hui Lee, Kenneth J. Shea

Journal of the American Chemical Society　Vol. 142　No. 5　p. 2338-2345　2020/02/05　Research paper (scientific journal)

Affinity purification of multifunctional oligomeric ligands synthesized via controlled radical polymerization

Yu Hoshino, Shinnosuke Shimohara, Yusuke Wada, Masahiko Nakamoto, Yoshiko Miura

Journal of Materials Chemistry B　Vol. 8　No. 26　p. 5597-5601　2020　Research paper (scientific journal)

Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery

Hiroyuki Koide, Tatsuya Fukuta, Anna Okishim, Saki Ariizumi, Chiaki Kiyokawa, Hiroki Tsuchida, Masahiko Nakamoto, Keiichi Yoshimatsu, Hidenori Ando, Takehisa Dewa, Tomohiro Asai, Naoto Oku, Yu Hoshino, Kenneth J. Shea

Biomacromolecules　Vol. 20　No. 10　p. 3648-3657　2019/10/14　Research paper (scientific journal)

Reversible pKa Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions

Yu Hoshino, Toshiki Jibiki, Masahiko Nakamoto, Yoshiko Miura

ACS Applied Materials & Interfaces　Vol. 10　No. 37　p. 31096-31105　2018/09/19　Research paper (scientific journal)

Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins

Hiroyuki Koide, Hiroki Tsuchida, Masahiko Nakamoto, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Tomohiro Asai, Yu Hoshino, Naoto Oku

Journal of Controlled Release　Vol. 268　p. 335-342　2017/12　Research paper (scientific journal)

Wide-range pKa tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli

Yu Hoshino, Takaaki Miyoshi, Masahiko Nakamoto, Yoshiko Miura

Journal of Materials Chemistry B　Vol. 5　No. 46　p. 9204-9210　2017　Research paper (scientific journal)

Design of Synthetic Polymer Nanoparticles That Facilitate Resolubilization and Refolding of Aggregated Positively Charged Lysozyme

Masahiko Nakamoto, Tadashi Nonaka, Kenneth J. Shea, Yoshiko Miura, Yu Hoshino

Journal of the American Chemical Society　Vol. 138　No. 13　p. 4282-4285　2016/04/06　Research paper (scientific journal)

Effect of Physical Properties of Nanogel Particles on the Kinetic Constants of Multipoint Protein Recognition Process

Masahiko Nakamoto, Yu Hoshino, Yoshiko Miura

Biomacromolecules　Vol. 15　No. 2　p. 541-547　2014/02/10　Research paper (scientific journal)

Control of Protein-Binding Kinetics on Synthetic Polymer Nanoparticles by Tuning Flexibility and Inducing Conformation Changes of Polymer Chains

Yu Hoshino, Masahiko Nakamoto, Yoshiko Miura

Journal of the American Chemical Society　Vol. 134　No. 37　p. 15209-15212　2012/09/19　Research paper (scientific journal)