Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.

Hiromichi Sato, Sikun Meng, Kazuki Sasaki, Shogo Kobayashi, Kansuke Kido, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Daisuke Motooka, Shizuka Uchida, Ken Ofusa, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi, Tomoaki Hara, Hideshi Ishii

International journal of oncology　Vol. 65　No. 1　2024/07　Research paper (scientific journal)

Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications.

Hiromichi Sato, Sikun Meng, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Kazuki Sasaki, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Biomedicines　Vol. 12　No. 6　2024/06/17　Research paper (scientific journal)

Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease.

Tomoaki Hara, Sikun Meng, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Tsuji, Takeshi Yabumoto, Yuichiro Doki, Hidetoshi Eguchi, Shizuka Uchida, Hideshi Ishii

Cancer science　2024/04/28　Research paper (scientific journal)

High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker.

Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Kazuki Sasaki, Yu Takeda, Yoshiko Tsuji, Yasuko Arao, Ken Ofusa, Toru Kitagawa, Daisaku Yamada, Hidenori Takahashi, Shogo Kobayashi, Daisuke Motooka, Yutaka Suzuki, Sarah Rennie, Shizuka Uchida, Masaki Mori, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cancer science　2024/04/24　Research paper (scientific journal)

RN7SL1 may be translated under oncogenic conditions.

Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Hiromichi Sato, Daisuke Motooka, Shizuka Uchida, Hideshi Ishii

Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 12　2024/03/19　Research paper (scientific journal)

Revealing neuropilin expression patterns in pancreatic cancer: From single‑cell to therapeutic opportunities (Review).

Sikun Meng, Tomoaki Hara, Hiromichi Sato, Shotaro Tatekawa, Yoshiko Tsuji, Yoshiko Saito, Yumiko Hamano, Yasuko Arao, Noriko Gotoh, Kazuhiko Ogawa, Hideshi Ishii

Oncology letters　Vol. 27　No. 3　p. 113-113　2024/03　Research paper (scientific journal)

<scp>RNA</scp> methylation in inflammatory bowel disease

Yuki Ozato, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Mamoru Uemura, Takeshi Yabumoto, Shizuka Uchida, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cancer Science　2024/01/23　Research paper (scientific journal)

[Future Perspectives of Single-Cell RNA Sequencing in Cancer Research].

Sikun Meng, Tomoaki Hara, Hideshi Ishii

Gan to kagaku ryoho. Cancer & chemotherapy　Vol. 51　No. 1　p. 14-23　2024/01　Research paper (scientific journal)

Drug Discovery and Development of miRNA-Based Nucleotide Drugs for Gastrointestinal Cancer

Hiromichi Sato, Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Kazuki Sasaki, Norikatsu Miyoshi, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Biomedicines　Vol. 11　No. 8　p. 2235-2235　2023/08/09　Research paper (scientific journal)

Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions

Hiromichi Sato, Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Kazuki Sasaki, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cancer Science　Vol. 114　No. 9　p. 3487-3495　2023/07/21　Research paper (scientific journal)

Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)

Yoshiko Tsuji, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Yasuko Arao, Ken Ofusa, Hideshi Ishii

Oncology Letters　Vol. 26　No. 2　2023/06/20　Research paper (scientific journal)

T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes

Rebecca Distefano, Mirolyuba Ilieva, Jens Hedelund Madsen, Hideshi Ishii, Masanori Aikawa, Sarah Rennie, Shizuka Uchida

Non-Coding RNA　Vol. 9　No. 3　p. 30-30　2023/05/08　Research paper (scientific journal)

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma.

Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya, Junichi Takahashi, Keisuke Kosai, Seiichiro Takao, Yushi Motomura, Kuniaki Sato, Qingjiang Hu, Atsushi Fujii, Hiroaki Wakiyama, Taro Tobo, Hiroki Uchida, Keishi Sugimachi, Kohei Shibata, Tohru Utsunomiya, Shogo Kobayashi, Hideshi Ishii, Takanori Hasegawa, Takaaki Masuda, Yusuke Matsui, Atsushi Niida, Tomoyoshi Soga, Yutaka Suzuki, Satoru Miyano, Hiroyuki Aburatani, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Keiichi I Nakayama, Teppei Shimamura, Tatsuhiro Shibata, Koshi Mimori

British journal of cancer　Vol. 128　No. 12　p. 2206-2217　2023/04/19　Research paper (scientific journal)

Data from A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones

Masayasu Toratani, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Keisuke Tamari, Zhihao Li, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Katsutoshi Sato, Daisuke Motooka, Daisuke Okuzaki, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

2023/03/31

Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Ken Ofusa, Tsunekazu Mizushima, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii

British journal of cancer　Vol. 128　No. 10　p. 1828-1837　2023/03/03　Research paper (scientific journal)

線維芽細胞の老化の指標となるニコチンアミドに関する研究

千々松 良太, 孟 思こん, 原 知明, 石井 秀始

代謝異常治療研究基金研究業績集　Vol. 46　p. 41-49　2023

Direct observation of DNA alterations induced by a DNA disruptor

Takahito Ohshiro, Ayumu Asai, Masamitsu Konno, Mayuka Ohkawa, Yuki Komoto, Ken Ofusa, Hideshi Ishii, Masateru Taniguchi

Scientific Reports　Vol. 12　No. 1　2022/12　Research paper (scientific journal)

Pancreatic Cancer Research beyond DNA Mutations.

Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Mirei Ogita, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Shizuka Uchida, Hideshi Ishii

Biomolecules　Vol. 12　No. 10　p. 1503-1503　2022/10/17　Research paper (scientific journal)

Circulating cancer-associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer.

Yusuke Yoshioka, Manami Shimomura, Keigo Saito, Hideshi Ishii, Yuichiro Doki, Hidetoshi Eguchi, Tetsuya Nakatsura, Takao Itoi, Masahiko Kuroda, Masaki Mori, Takahiro Ochiya

Cancer science　Vol. 113　No. 10　p. 3498-3509　2022/10　Research paper (scientific journal)

Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma.

Katsunori Matsushita, Shogo Kobayashi, Hirofumi Akita, Masamitsu Konno, Ayumu Asai, Takehiro Noda, Yoshifumi Iwagami, Tadafumi Asaoka, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cancer reports (Hoboken, N.J.)　Vol. 5　No. 10　2022/10　Research paper (scientific journal)

RNA Modification in Inflammatory Bowel Diseases

Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii

Biomedicines　Vol. 10　No. 7　p. 1695-1695　2022/07/13　Research paper (scientific journal)

N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma.

Shotaro Tatekawa, Keisuke Tamari, Ryota Chijimatsu, Masamitsu Konno, Daisuke Motooka, Suguru Mitsufuji, Hirofumi Akita, Shogo Kobayashi, Yoshiki Murakumo, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii, Kazuhiko Ogawa

Scientific reports　Vol. 12　No. 1　p. 11074-11074　2022/06/30　Research paper (scientific journal)

Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma

Ryota Chijimatsu, Shogo Kobayashi, Yu Takeda, Masatoshi Kitakaze, Shotaro Tatekawa, Yasuko Arao, Mika Nakayama, Naohiro Tachibana, Taku Saito, Daisuke Ennishi, Shuta Tomida, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Daisuke Okuzaki, Daisuke Motooka, Takahito Ohshiro, Masateru Taniguchi, Yutaka Suzuki, Kazuhiko Ogawa, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

iScience　Vol. 25　No. 8　p. 104659-104659　2022/06　Research paper (scientific journal)

EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases

Yasuko Arao, Mika Nakayama, Yoshiko Tsuji, Yumiko Hamano, Chihiro Otsuka, Andrea Vecchione, Ken Ofusa, Hideshi Ishii

Biomedicines　Vol. 10　No. 6　p. 1280-1280　2022/05/30　Research paper (scientific journal)

Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets.

Yu Takeda, Ryota Chijimatsu, Ken Ofusa, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cancer science　Vol. 113　No. 4　p. 1097-1104　2022/04　Research paper (scientific journal)

Techniques to detect epitranscriptomic marks.

Ken Ofusa, Ryota Chijimatsu, Hideshi Ishii

American journal of physiology. Cell physiology　Vol. 322　No. 4　2022/03/16　Research paper (scientific journal)

Nematode-Applied Technology for Human Tumor Microenvironment Research and Development

Eric di Luccio, Satoru Kaifuchi, Nobuaki Kondo, Ryota Chijimatsu, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii

CURRENT ISSUES IN MOLECULAR BIOLOGY　Vol. 44　No. 2　p. 988-997　2022/02　Research paper (scientific journal)

Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma.

Hiromichi Sato, Tomoaki Hara, Shotaro Tatekawa, Kazuki Sasaki, Shogo Kobayashi, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, Kazuhiko Ogawa, Shizuka Uchida, Hideshi Ishii

Frontiers in physiology　Vol. 13　p. 1025923-1025923　2022　Research paper (scientific journal)

Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment.

Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Hideshi Ishii

Frontiers in oncology　Vol. 12　p. 1018333-1018333　2022　Research paper (scientific journal)

Computational healthcare: Present and future perspectives (Review).

Ayumu Asai, Masamitsu Konno, Masateru Taniguchi, Andrea Vecchione, Hideshi Ishii

Experimental and therapeutic medicine　Vol. 22　No. 6　p. 1351-1351　2021/12　Research paper (scientific journal)

Methylosystem for Cancer Sieging Strategy.

Shotaro Tatekawa, Ken Ofusa, Ryota Chijimatsu, Andrea Vecchione, Keisuke Tamari, Kazuhiko Ogawa, Hideshi Ishii

Cancers　Vol. 13　No. 20　2021/10/12　Research paper (scientific journal)

Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC.

Takahito Ohshiro, Masamitsu Konno, Ayumu Asai, Yuki Komoto, Akira Yamagata, Yuichiro Doki, Hidetoshi Eguchi, Ken Ofusa, Masateru Taniguchi, Hideshi Ishii

Scientific reports　Vol. 11　No. 1　p. 19304-19304　2021/09/29　Research paper (scientific journal)

Alteration of tumor microenvironment and radioresistance induced by clonal hematopoiesis(和訳中)

立川 章太郎, 元岡 大祐, 玉利 慶介, 皆巳 和賢, 瀬尾 雄二, 高橋 豊, 今野 雅允, 石井 秀始, 猪原 秀典, 小川 和彦

日本血液学会学術集会　Vol. 83回　p. OS3-3　2021/09

大腸がん腫瘍内微小環境内におけるTissue resident memory T cellsの役割

北風 雅敏, 今野 雅允, 浅井 歩, 千々松 良太, 藤野 志季, 荻野 崇之, 高橋 秀和, 三吉 範克, 植村 守, 佐藤 太郎, 水島 恒和, 土岐 祐一郎, 江口 英利, 石井 秀始

日本癌学会総会記事　Vol. 80回　p. [J12-4]　2021/09

Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer.

Ayumu Asai, Masamitsu Konno, Miyuki Ozaki, Koichi Kawamoto, Ryota Chijimatsu, Nobuaki Kondo, Takaaki Hirotsu, Hideshi Ishii

Oncotarget　Vol. 12　No. 17　p. 1687-1696　2021/08/17　Research paper (scientific journal)

Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions.

Masatoshi Kitakaze, Ryota Chijimatsu, Andrea Vecchione, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

International journal of molecular sciences　Vol. 22　No. 14　2021/07/14　Research paper (scientific journal)

Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer.

Yu Takeda, Ryota Chijimatsu, Andrea Vecchione, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii

International journal of molecular sciences　Vol. 22　No. 14　2021/07/06　Research paper (scientific journal)

Targeting cancer stem cells in refractory cancer.

Norikatsu Miyoshi, Naotsugu Haraguchi, Tsunekazu Mizushima, Hideshi Ishii, Hirofumi Yamamoto, Masaki Mori

Regenerative therapy　Vol. 17　p. 13-19　2021/06　Research paper (scientific journal)

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

Channabasavaiah B Gurumurthy, Aidan R O'Brien, Rolen M Quadros, John Adams Jr, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K Batra, Marie-Claude Beauchamp, Kathleen A Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D'Hont, Katharine Dibb, James D Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya Guntur, Huiping Guo, Donald W Harms, Anne Harrington, Kathryn E Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie Jerome-Majeweska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-Ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P Ponnusamy, David Ray, Ronald J Redder, Clifford J Rosen, Nikki Ross, Mark T Ruhe, Larisa Ryzhova, Ane M Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J Willis, Christian S Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R Thompson, K C Kent Lloyd, Joshua A Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M Miano, Gaetan Burgio

Genome biology　Vol. 22　No. 1　p. 99-99　2021/04/07　Research paper (scientific journal)

腫瘍内Tissue Resident Memory T cells(Trm)は周囲の免疫系を左右して大腸がんにおける全生存期間、無再発期間の改善に寄与する

北風 雅敏, 石井 秀始, 今野 雅允, 浅井 歩, 藤野 志季, 荻野 崇之, 高橋 秀和, 三吉 範克, 植村 守, 水島 恒和, 土岐 祐一郎, 江口 英利

日本外科学会定期学術集会抄録集　Vol. 121回　p. PS-1　2021/04

Epitranscriptomics and Diseases

Masamitsu Konno, Hideshi Ishii

RNA Technologies　Vol. 12　p. 121-140　2021　Part of collection (book)

A Four-Dimensional Organoid System to Visualize Cancer Cell Vascular Invasion

Kiminori Yanagisawa, Masamitsu Konno, Hao Liu, Shinji Irie, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Michiya Matsusaki, Hideshi Ishii

Biology　2020/10　Research paper (scientific journal)

組織常駐型メモリーT細胞は大腸癌患者の生存率を予測するマーカーとして有用である

北風 雅敏, 今野 雅允, 浅井 歩, 藤野 志季, 荻野 崇之, 高橋 秀和, 三吉 範克, 植村 守, 佐藤 太郎, 水島 恒和, 土岐 祐一郎, 江口 英利, 石井 秀始

日本癌学会総会記事　Vol. 79回　p. OJ14-3　2020/10

組織常駐型メモリーT細胞は大腸癌患者の生存率を予測するマーカーとして有用である

北風 雅敏, 今野 雅允, 浅井 歩, 藤野 志季, 荻野 崇之, 高橋 秀和, 三吉 範克, 植村 守, 佐藤 太郎, 水島 恒和, 土岐 祐一郎, 江口 英利, 石井 秀始

日本癌学会総会記事　Vol. 79回　p. OJ14-3　2020/10

Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes

Yu Takeda, Shogo Kobayashi, Masatoshi Kitakaze, Daisaku Yamada, Hirofumi Akita, Ayumu Asai, Masamitsu Konno, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Andrea Vecchione, Masateru Taniguchi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Cells　Vol. 9　No. 7　p. 1645-1645　2020/07/09　Research paper (scientific journal)

State-of-the-Art Technology of Model Organisms for Current Human Medicine.

Masamitsu Konno, Ayumu Asai, Toru Kitagawa, Masami Yabumoto, Ken Ofusa, Takahiro Arai, Takaaki Hirotsu, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

Diagnostics (Basel, Switzerland)　Vol. 10　No. 6　2020/06/10　Research paper (scientific journal)

Convolutional Neural Network Can Recognize Drug Resistance of Single Cancer Cells.

Kiminori Yanagisawa, Masayasu Toratani, Ayumu Asai, Masamitsu Konno, Hirohiko Niioka, Tsunekazu Mizushima, Taroh Satoh, Jun Miyake, Kazuhiko Ogawa, Andrea Vecchione, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

International journal of molecular sciences　Vol. 21　No. 9　2020/04/30　Research paper (scientific journal)

COVID-19 Drug Discovery Using Intensive Approaches.

Ayumu Asai, Masamitsu Konno, Miyuki Ozaki, Chihiro Otsuka, Andrea Vecchione, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Masateru Taniguchi, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii

International journal of molecular sciences　Vol. 21　No. 8　2020/04/18　Research paper (scientific journal)

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA.

Jun Koseki, Masamitsu Konno, Ayumu Asai, Naohiro Horie, Kenta Tsunekuni, Koichi Kawamoto, Satoshi Obika, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 10　No. 1　p. 1138-1138　2020/01/24　Research paper (scientific journal)

Hereditary pancreatitis model by blastocyst complementation in mouse

Oncotarget　2020

One-carbon metabolism for cancer diagnostic and therapeutic approaches.

Cancer Lett.　Vol. 470　p. 141-148　2020

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure.

Kenta Tsunekuni, Masamitsu Konno, Naotsugu Haraguchi, Jun Koseki, Ayumu Asai, Kazuaki Matsuoka, Takashi Kobunai, Teiji Takechi, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 9　No. 1　p. 14861-14861　2019/10/16　Research paper (scientific journal)

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice.

Yuji Ueda, Koichi Kawamoto, Masamitsu Konno, Kozo Noguchi, Satoru Kaifuchi, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Takaaki Hirotsu, Masaki Mori, Hideshi Ishii

Oncotarget　Vol. 10　No. 52　p. 5412-5418　2019/09/10　Research paper (scientific journal)

Distinct methylation levels of mature microRNAs in gastrointestinal cancers.

Masamitsu Konno, Jun Koseki, Ayumu Asai, Akira Yamagata, Teppei Shimamura, Daisuke Motooka, Daisuke Okuzaki, Koichi Kawamoto, Tsunekazu Mizushima, Hidetoshi Eguchi, Shuji Takiguchi, Taroh Satoh, Koshi Mimori, Takahiro Ochiya, Yuichiro Doki, Ken Ofusa, Masaki Mori, Hideshi Ishii

Nature communications　Vol. 10　No. 1　p. 3888-3888　2019/08/29　Research paper (scientific journal)

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Channabasavaiah B Gurumurthy, Aidan R O'Brien, Rolen M Quadros, John Adams Jr, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K Batra, Marie-Claude Beauchamp, Kathleen A Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D'Hont, Katharine M Dibb, James D Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya R Guntur, Huiping Guo, Donald W Harms, Anne Harrington, Kathryn E Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie A Jerome-Majewska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-Ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P Ponnusamy, David Ray, Ronald J Redder, Clifford J Rosen, Nikki Ross, Mark T Ruhe, Larisa Ryzhova, Ane M Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew W Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J Willis, Christian S Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R Thompson, K C Kent Lloyd, Joshua A Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M Miano, Gaetan Burgio

Genome biology　Vol. 20　No. 1　p. 171-171　2019/08/26　Research paper (scientific journal)

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma.

Katsunori Matsushita, Takumi Okuda, Shohei Mori, Masamitsu Konno, Hidetoshi Eguchi, Ayumu Asai, Jun Koseki, Yoshifumi Iwagami, Daisaku Yamada, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Yuuya Kasahara, Kunihiko Morihiro, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Satoshi Obika

ChemMedChem　Vol. 14　No. 15　p. 1384-1391　2019/08/06　Research paper (scientific journal)

Significant epitranscriptomes in heterogeneous cancer.

Masamitsu Konno, Masateru Taniguchi, Hideshi Ishii

Cancer science　Vol. 110　No. 8　p. 2318-2327　2019/08

Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells.

Mitsunobu Takeda, Jun Koseki, Hidekazu Takahashi, Norikatsu Miyoshi, Naohiro Nishida, Junichi Nishimura, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Naotsugu Haraguchi

Cancer research　Vol. 79　No. 7　p. 1426-1437　2019/04/01　Research paper (scientific journal)

セツキシマブ耐性大腸癌における化学療法感受性とmicroRNAの関連性

波多 豪, 工藤 敏啓, 今野 雅允, 坂井 大介, 西田 尚弘, 三吉 範克, 高橋 秀和, 原口 直紹, 西村 潤一, 畑 泰司, 松田 宙, 水島 恒和, 山本 浩文, 石井 秀始, 土岐 祐一郎, 森 正樹, 佐藤 太郎

日本外科学会定期学術集会抄録集　Vol. 119回　p. PS-3　2019/04

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance.

Yuji Takaoka, Masamitsu Konno, Jun Koseki, Hugh Colvin, Ayumu Asai, Keisuke Tamari, Taroh Satoh, Masaki Mori, Yuichiro Doki, Kazuhiko Ogawa, Hideshi Ishii

Cancer science　Vol. 110　No. 4　p. 1331-1339　2019/04　Research paper (scientific journal)

Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution.

Takahito Ohshiro, Yuuki Komoto, Masamitsu Konno, Jun Koseki, Ayumu Asai, Hideshi Ishii, Masateru Taniguchi

Scientific reports　Vol. 9　No. 1　p. 3886-3886　2019/03/07　Research paper (scientific journal)

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.

Kana Tominaga, Hiroshi Minato, Takahiko Murayama, Asako Sasahara, Tatsunori Nishimura, Etsuko Kiyokawa, Hajime Kanauchi, Seiichiro Shimizu, Ayaka Sato, Kotoe Nishioka, Ei-Ichi Tsuji, Masao Yano, Toshihisa Ogawa, Hideshi Ishii, Masaki Mori, Koichi Akashi, Koji Okamoto, Masahiko Tanabe, Kei-Ichiro Tada, Arinobu Tojo, Noriko Gotoh

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 2　p. 625-630　2019/01/08　Research paper (scientific journal)

Single molecule electrical identification of epigenetic variations by nanofluid integrated nanogap devices

Takahito Ohshiro, Yuuki Komoto, Masamitsu Konno, Jun Koseki, Ayumu Asai, Hideshi Ishii, Masateru Taniguchi

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019　p. 188-189　2019　Research paper (international conference proceedings)

AI for medical use.

Oncotarget　Vol. 10　No. 2　p. 86-87　2019

Disruption of endolysosomal RAB5/7 efficiently eliminates colorectal cancer stem cells.

Cancer Res.　Vol. 79　No. 7　p. 1426-1437　2019

Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.

Reishi Toshiyama, Masamitsu Konno, Hidetoshi Eguchi, Hiroyasu Takemoto, Takehiro Noda, Ayumu Asai, Jun Koseki, Naotsugu Haraguchi, Yuji Ueda, Katsunori Matsushita, Kei Asukai, Tomofumi Ohashi, Yoshifumi Iwagami, Daisaku Yamada, Daisuke Sakai, Tadafumi Asaoka, Toshihiro Kudo, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Taroh Satoh, Yuichiro Doki, Nobuhiro Nishiyama, Masaki Mori, Hideshi Ishii

Oncogene　Vol. 38　No. 2　p. 244-260　2019/01　Research paper (scientific journal)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2.

Ayumu Asai, Jun Koseki, Masamitsu Konno, Tatsunori Nishimura, Noriko Gotoh, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Heliyon　Vol. 4　No. 12　2018/12　Research paper (scientific journal)

c-Mycを介したエピトランスクリプトームメチルリーダータンパクYTHDF1の大腸癌進行促進(Epitranscriptome Methyl-reader Protein YTHDF1 Via Regulation of c-Myc Facilitates Colorectal Cancer Progression)

稲垣 千晶, 今野 雅允, 浅井 歩, 小関 準, 西沢 佑次郎, 木村 明恵, 大鶴 徹, 西田 尚弘, 坂井 大介, 土岐 祐一郎, 森 正樹, 佐藤 太郎, 石井 秀始

日本癌学会総会記事　Vol. 77回　p. 2406-2406　2018/09

癌幹細胞の代謝とエピジェネティクスの関係を標的とした創薬(Elucidation of a linkage of cancer metabolism and epigenetic control in cancer stem cells for drug discovery)

玉利 慶介, 今野 雅允, 小関 準, 浅井 歩, 佐藤 太郎, 土岐 祐一郎, 森 正樹, 小川 和彦, 石井 秀始

日本癌学会総会記事　Vol. 77回　p. 918-918　2018/09

ミトコンドリア・ピルビン酸輸送体は上皮間葉形質転換と放射線抵抗性を制御する(Mitochondrial pyruvate career expression controls epithelial mesenchymal transition and radiation resistance)

高岡 祐史, 今野 雅允, 小関 準, 浅井 歩, 玉利 慶介, 土岐 祐一郎, 森 正樹, 石井 秀始, 小川 和彦

日本癌学会総会記事　Vol. 77回　p. 1364-1364　2018/09

Cell-free culture conditioned medium elicits pancreatic β cell lineage-specific epigenetic reprogramming in mice.

Koichi Kawamoto, Tomofumi Ohashi, Masamitsu Konno, Naohiro Nishida, Jun Koseki, Hidetoshi Matsui, Daisuke Sakai, Toshihiro Kudo, Hidetoshi Eguchi, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology letters　Vol. 16　No. 3　p. 3255-3259　2018/09　Research paper (scientific journal)

Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure.

Sung-Jae Baek, Katsutoshi Sato, Naohiro Nishida, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Masamitsu Konno, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

Oncology letters　Vol. 16　No. 3　p. 3389-3393　2018/09　Research paper (scientific journal)

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah Gurumurthy, Rolen Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie Jerome-Majeweska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, KC. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio

2018/08/30

The mitochondrial one-carbon metabolic pathway is associated with patient survival in pancreatic cancer.

Kozo Noguchi, Masamitsu Konno, Jun Koseki, Naohiro Nishida, Koichi Kawamoto, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology letters　Vol. 16　No. 2　p. 1827-1834　2018/08　Research paper (scientific journal)

c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.

Kozo Noguchi, Masamitsu Konno, Hidetoshi Eguchi, Koichi Kawamoto, Ryouta Mukai, Naohiro Nishida, Jun Koseki, Hiroshi Wada, Hirofumi Akita, Taroh Satoh, Shigeru Marubashi, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology letters　Vol. 16　No. 2　p. 1892-1898　2018/08　Research paper (scientific journal)

脂肪酸代謝を介し膵星細胞は膵の炎症と線維化を引き起こす

植田 裕, 畑 知樹, 今野 雅允, 山田 大作, 川本 弘一, 小林 省吾, 江口 英利, 土岐 祐一郎, 森 正樹, 石井 秀始

日本消化器外科学会総会　Vol. 73回　p. 961-961　2018/07

Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer.

Reishi Toshiyama, Masamitsu Konno, Hidetoshi Eguchi, Ayumu Asai, Takehiro Noda, Jun Koseki, Kei Asukai, Tomofumi Ohashi, Katsunori Matsushita, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology letters　Vol. 15　No. 5　p. 8125-8133　2018/05　Research paper (scientific journal)

Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model.

Hisataka Ogawa, Masamitsu Konno, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Tsunekazu Mizushima, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Biomedical reports　Vol. 8　No. 5　p. 497-499　2018/05　Research paper (scientific journal)

Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma.

Tomofumi Ohashi, Hidetoshi Eguchi, Koichi Kawamoto, Masamitsu Konno, Ayumu Asai, Hugh Colvin, Yuji Ueda, Hirofumi Takaoka, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Shogo Kobayashi, Jun Koseki, Taroh Satoh, Kazuhiko Ogawa, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology reports　Vol. 39　No. 3　p. 1276-1282　2018/03　Research paper (scientific journal)

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

Kosuke Taketo, Masamitsu Konno, Ayumu Asai, Jun Koseki, Masayasu Toratani, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Kazuhiko Ogawa

International journal of oncology　Vol. 52　No. 2　p. 621-629　2018/02　Research paper (scientific journal)

Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer.

Yujiro Nishizawa, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Naohiro Nishida, Naotsugu Haraguchi, Daisuke Sakai, Toshihiro Kudo, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 52　No. 2　p. 453-460　2018/02　Research paper (scientific journal)

Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells.

Masamitsu Konno, Hidetoshi Matsui, Jun Koseki, Ayumu Asai, Yoshihiro Kano, Koichi Kawamoto, Naohiro Nishida, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 8　No. 1　p. 899-899　2018/01/17　Research paper (scientific journal)

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis.

Jun Koseki, Masamitsu Konno, Ayumu Asai, Hugh Colvin, Koichi Kawamoto, Naohiro Nishida, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 8　No. 1　p. 303-303　2018/01/10　Research paper (scientific journal)

The Significance of Histone demethylase NO66 in colorectal cancer development

Nishizawa Yujiro, Nishida Naohiro, Konno Masamitsu, Kawamoto Koichi, Koseki Jun, Asai Ayumu, Nishimura Junichi, Hata Taishi, Matsuda Chu, Mizushima Tsunekazu, Doki Yuichiro, Mori Masaki, Ishii Hideshi

CANCER SCIENCE　Vol. 109　2018/01

GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

Carcinogenesis.　Vol. 39　No. 5　p. 652-660　2018

Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.

Keisuke Tamari, Masamitsu Konno, Ayumu Asai, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Noriyuki Murai, Senya Matsufuji, Fumiaki Isohashi, Taroh Satoh, Noriko Goto, Shinji Tanaka, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

Cell death discovery　Vol. 4　p. 104-104　2018　Research paper (scientific journal)

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.

Porc. Natl. Acad. Sci. U.S.A.　Vol. 116　No. 2　p. 625-630　2018

A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones

Masayasu Toratani, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Keisuke Tamari, Zhihao Li, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Katsutoshi Sato, Daisuke Motooka, Daisuke Okuzaki, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

CANCER RESEARCH　Vol. 78　No. 23　p. 6703-6707　2018　Research paper (scientific journal)

Low expression of the GOPC is a poor prognostic marker in colorectal cancer

Nobuyoshi Ohara, Naotsugu Haraguchi, Jun Koseki, Yujiro Nishizawa, Kenji Kawai, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

ONCOLOGY LETTERS　Vol. 14　No. 4　p. 4483-4490　2017/10　Research paper (scientific journal)

膵癌のミトコンドリア代謝が関わるEMT現象の解明

高岡 祐史, 石井 秀始, Colvin Hugh, 西田 尚弘, 今野 雅允, 浅井 歩, 川本 弘一, 小関 準, 玉利 慶介, 土岐 祐一郎, 森 正樹, 小川 和彦

日本癌学会総会記事　Vol. 76回　p. P-1181　2017/09

ポリアミンはLSD1を介して癌幹細胞のエピジェネティクスを制御する

玉利 慶介, 石井 秀始, 今野 雅允, 浅井 歩, 小関 準, 虎谷 昌保, 土岐 祐一郎, 森 正樹, 小川 和彦

日本癌学会総会記事　Vol. 76回　p. P-1207　2017/09

MicroRNA profiles involved in trifluridine resistance.

Kenta Tsunekuni, Masamitsu Konno, Ayumu Asai, Jun Koseki, Takashi Kobunai, Teiji Takechi, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncotarget　Vol. 8　No. 32　p. 53017-53027　2017/08/08　Research paper (scientific journal)

Micro-RNA-130a-3p Regulates Gemcitabine Resistance via PPARG in Cholangiocarcinoma.

Kei Asukai, Koichi Kawamoto, Hidetoshi Eguchi, Masamitsu Konno, Ayumu Asai, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Naohiro Nishida, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Annals of surgical oncology　Vol. 24　No. 8　p. 2344-2352　2017/08　Research paper (scientific journal)

Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism.

Naoki Yamada, Yuto Honda, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Masamitsu Konno, Hideshi Ishii, Masaki Mori, Nobuhiro Nishiyama

Scientific reports　Vol. 7　No. 1　p. 6077-6077　2017/07/20　Research paper (scientific journal)

Novel serum microRNAs that enable liquid biopsy for colorectal cancer: validation study of large cohort

Takamaru Hiroyuki, Saito Yutaka, Sakamoto Taku, Abe Seiichiro, Yamada Masayoshi, Nakajima Takeshi, Sudo Kazuki, Kato Ken, Kawauchi Junpei, Takizawa Satoko, Sakamoto Hiromi, Kojima Motohiro, Ochiai Atsushi, Niida Shumpei, Ishii Hideshi, Takamaru Tomoko, Matsuzaki Juntaro, Matsuda Takahisa, Ochiya Takahiro

CANCER RESEARCH　Vol. 77　2017/07

Correction: Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.

Ryutaro Uchi, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Hidenari Hirata, Keishi Sugimachi, Genta Sawada, Takeshi Iwaya, Junji Kurashige, Yoshiaki Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Kenichi Chiba, Yuichi Shiraishi, Genta Nagae, Kenichi Yoshida, Yasunobu Nagata, Hiroshi Haeno, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Hisae Iinuma, Shin Sasaki, Satoshi Nagayama, Kazutaka Yamada, Shinichi Yachida, Mamoru Kato, Tatsuhiro Shibata, Eiji Oki, Hiroshi Saeki, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Shizuo Komune, Masaki Mori, Yutaka Suzuki, Ken Yamamoto, Hiroyuki Aburatani, Seishi Ogawa, Satoru Miyano, Koshi Mimori

PLoS genetics　Vol. 13　No. 5　2017/05

The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).

Masamitsu Konno, Ayumu Asai, Koichi Kawamoto, Naohiro Nishida, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 50　No. 4　p. 1057-1063　2017/04　Research paper (scientific journal)

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

K. Tominaga, T. Shimamura, N. Kimura, T. Murayama, D. Matsubara, H. Kanauchi, A. Niida, S. Shimizu, K. Nishioka, E-I Tsuji, M. Yano, S. Sugano, Y. Shimono, H. Ishii, H. Saya, M. Mori, K. Akashi, K-I Tada, T. Ogawa, A. Tojo, S. Miyano, N. Gotoh

ONCOGENE　Vol. 36　No. 9　p. 1276-1286　2017/03　Research paper (scientific journal)

Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer.

Yujiro Nishizawa, Naohiro Nishida, Masamitsu Konno, Koichi Kawamoto, Ayumu Asai, Jun Koseki, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Annals of surgical oncology　Vol. 24　No. 3　p. 841-849　2017/03　Research paper (scientific journal)

High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.

Naotsugu Haraguchi, Nobuyoshi Ohara, Jun Koseki, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

Molecular and clinical oncology　Vol. 6　No. 1　p. 130-134　2017/01　Research paper (scientific journal)

The importance of mitochondrial folate enzymes in human colorectal cancer.

Masaaki Miyo, Masamitsu Konno, Hugh Colvin, Naohiro Nishida, Jun Koseki, Koichi Kawamoto, Kenta Tsunekuni, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology reports　Vol. 37　No. 1　p. 417-425　2017/01　Research paper (scientific journal)

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer.

Oncotarget　Vol. 9　No. 7　p. 7476-7486　2017

Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer.

Masaaki Miyo, Masamitsu Konno, Naohiro Nishida, Toshinori Sueda, Kozo Noguchi, Hidetoshi Matsui, Hugh Colvin, Koichi Kawamoto, Jun Koseki, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Noriko Gotoh, Fumio Matsuda, Taroh Satoh, Tsunekazu Mizushima, Hiroshi Shimizu, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 6　p. 38415-38415　2016/12/07　Research paper (scientific journal)

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer.

Hugh Colvin, Naohiro Nishida, Masamitsu Konno, Naotsugu Haraguchi, Hidekazu Takahashi, Junichi Nishimura, Taishi Hata, Koichi Kawamoto, Ayumu Asai, Kenta Tsunekuni, Jun Koseki, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 6　p. 36289-36289　2016/11/08　Research paper (scientific journal)

MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy.

Sung-Jae Baek, Katsutoshi Sato, Naohiro Nishida, Jun Koseki, Rikako Azuma, Koichi Kawamoto, Masamitsu Konno, Kazuhiko Hayashi, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Kazuhiko Ogawa

Oncology reports　Vol. 36　No. 5　p. 2946-2950　2016/11　Research paper (scientific journal)

Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi

T. Yokobori, S. Suzuki, T. Miyazaki, M. Sohda, M. Sakai, N. Tanaka, D. Ozawa, K. Hara, H. Honjo, B. Altan, M. Fukuchi, H. Ishii, M. Iwatsuki, K. Sugimachi, T. Sudo, T. Iwaya, N. Nishida, K. Mimori, H. Kuwano, M. Mori

DISEASES OF THE ESOPHAGUS　Vol. 29　No. 7　p. 843-847　2016/10　Research paper (scientific journal)

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

Genta Sawada, Atsushi Niida, Ryutaro Uchi, Hidenari Hirata, Teppei Shimamura, Yutaka Suzuki, Yuichi Shiraishi, Kenichi Chiba, Seiya Imoto, Yusuke Takahashi, Takeshi Iwaya, Tomoya Sudo, Tomoatsu Hayashi, Hiroki Takai, Yoshihiro Kawasaki, Takashi Matsukawa, Hidetoshi Eguchi, Keishi Sugimachi, Fumiaki Tanaka, Hiromichi Suzuki, Ken Yamamoto, Hideshi Ishii, Makiko Shimizu, Hiroshi Yamazaki, Makoto Yamazaki, Yuji Tachimori, Yoshiaki Kajiyama, Shoji Natsugoe, Hiromasa Fujita, Kenichi Mafune, Yoichi Tanaka, David P. Kelsell, Claire A. Scott, Shoji Tsuji, Shinichi Yachida, Tatsuhiro Shibata, Sumio Sugano, Yuichiro Doki, Tetsu Akiyama, Hiroyuki Aburatani, Seishi Ogawa, Satoru Miyano, Masaki Mori, Koshi Mimori

GASTROENTEROLOGY　Vol. 150　No. 5　p. 1171-1182　2016/05　Research paper (scientific journal)

A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells.

Jun Koseki, Hidetoshi Matsui, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Yoshihiro Kano, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Scientific reports　Vol. 6　p. 20726-20726　2016/02/11　Research paper (scientific journal)

Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer.

Shinichiro Hasegawa, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Masamitsu Konnno, Hideshi Ishii, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

Oncology letters　Vol. 11　No. 2　p. 1560-1566　2016/02　Research paper (scientific journal)

Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

Ryutaro Uchi, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Hidenari Hirata, Keishi Sugimachi, Genta Sawada, Takeshi Iwaya, Junji Kurashige, Yoshiaki Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Kenichi Chiba, Yuichi Shiraishi, Genta Nagae, Kenichi Yoshida, Yasunobu Nagata, Hiroshi Haeno, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Hisae Iinuma, Shin Sasaki, Satoshi Nagayama, Kazutaka Yamada, Shinichi Yachida, Mamoru Kato, Tatsuhiro Shibata, Eiji Oki, Hiroshi Saeki, Ken Shirabe, Yoshinao Oda, Yoshihiko Maehara, Shizuo Komune, Masaki Mori, Yutaka Suzuki, Ken Yamamoto, Hiroyuki Aburatani, Seishi Ogawa, Satoru Miyano, Koshi Mimori

PLOS GENETICS　Vol. 12　No. 2　2016/02　Research paper (scientific journal)

BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.

Toshinori Sueda, Daisuke Sakai, Koichi Kawamoto, Masamitsu Konno, Naohiro Nishida, Jun Koseki, Hugh Colvin, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Scientific reports　Vol. 6　p. 18949-18949　2016/01/11　Research paper (scientific journal)

A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients.

Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Masaki Mori, Yuichiro Doki, Hideshi Ishii

International journal of oncology　Vol. 48　No. 1　p. 145-52　2016/01　Research paper (scientific journal)

A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer: Research for Reprogramming of Cancer Cells by MicroRNAs.

Susumu Miyazaki, Hirofumi Yamamoto, Norikatsu Miyoshi, Xin Wu, Hisataka Ogawa, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Masamitsu Konno, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Annals of surgical oncology　Vol. 22 Suppl 3　p. S1394-401-401　2015/12　Research paper (scientific journal)

Prognostic Impact of Peritumoral IL-17-Positive Cells and IL-17 Axis in Patients with Intrahepatic Cholangiocarcinoma.

Kei Asukai, Koichi Kawamoto, Hidetoshi Eguchi, Masamitsu Konno, Naohiro Nishida, Jun Koseki, Kozo Noguchi, Shinichiro Hasegawa, Hisataka Ogawa, Daisaku Yamada, Yoshito Tomimaru, Akira Tomokuni, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Gotoh, Shigeru Marubashi, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Annals of surgical oncology　Vol. 22 Suppl 3　p. S1524-31-31　2015/12　Research paper (scientific journal)

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review).

Sung-Jae Baek, Hideshi Ishii, Keisuke Tamari, Kazuhiko Hayashi, Naohiro Nishida, Masamitsu Konno, Koichi Kawamoto, Jun Koseki, Takahito Fukusumi, Shinichiro Hasegawa, Hisataka Ogawa, Atsushi Hamabe, Masaaki Miyo, Kozo Noguchi, Yuji Seo, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa

Oncology reports　Vol. 34　No. 5　p. 2233-7　2015/11　Research paper (scientific journal)

Cyclin G2: A novel independent prognostic marker in pancreatic cancer.

Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Noriko Gotoh, Shouichi Ohno, Norikazu Yabuta, Hiroshi Nojima, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Oncology letters　Vol. 10　No. 5　p. 2986-2990　2015/11　Research paper (scientific journal)

[CANCER REPROGRAMMING AND ITS CLINICAL APPLICABILITY].

Masamitsu Konno, Hideshi Ishii, Yuichiro Doki, Masaki Mori

Nihon Geka Gakkai zasshi　Vol. 116　No. 6　p. 357-9　2015/11

ハイスループットスクリーニングを用いた子宮頸癌癌幹細胞を標的とした放射線増感剤の同定

玉利 慶介, 石井 秀始, 今野 雅允, 西田 尚弘, 川本 弘一, 小関 準, 白 成栽, 土岐 祐一郎, 森 正樹, 小川 和彦

日本癌学会総会記事　Vol. 74回　p. P-2342　2015/10

[Therapeutic Implication Targeting for Cancer Stem Cells].

Kozo Noguchi, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Jun Koseki, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Taro Satoh, Hideshi Ishii

Gan to kagaku ryoho. Cancer & chemotherapy　Vol. 42　No. 9　p. 1036-9　2015/09　Research paper (scientific journal)

Susceptibility of pancreatic cancer stem cells to reprogramming.

Kozo Noguchi, Hidetoshi Eguchi, Masamitsu Konno, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Hiroshi Wada, Shigeru Marubashi, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Cancer science　Vol. 106　No. 9　p. 1182-7　2015/09　Research paper (scientific journal)

[Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells].

Masamitsu Konno, Atsushi Hamabe, Yuichiro Doki, Masaki Mori, Hideshi Ishii

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 56　No. 8　p. 1059-63　2015/08　Research paper (scientific journal)

Tumour-suppressive function of SIRT4 in human colorectal cancer

M. Miyo, H. Yamamoto, M. Konno, H. Colvin, N. Nishida, J. Koseki, K. Kawamoto, H. Ogawa, A. Hamabe, M. Uemura, J. Nishimura, T. Hata, I. Takemasa, T. Mizushima, Y. Doki, M. Mori, H. Ishii

BRITISH JOURNAL OF CANCER　Vol. 113　No. 3　p. 492-499　2015/07　Research paper (scientific journal)

Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer.

Hidekazu Takahashi, Junichi Nishimura, Yoshinori Kagawa, Yoshihiro Kano, Yusuke Takahashi, Xin Wu, Masayuki Hiraki, Atsushi Hamabe, Masamitsu Konno, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masaru Ishii, Koshi Mimori, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

Molecular cancer therapeutics　Vol. 14　No. 7　p. 1705-16　2015/07　Research paper (scientific journal)

Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.

Masamitsu Konno, Hideshi Ishii, Jun Koseki, Nobuhiro Tanuma, Naohiro Nishida, Koichi Kawamoto, Tatsunori Nishimura, Asuka Nakata, Hidetoshi Matsui, Kozou Noguchi, Miyuki Ozaki, Yuko Noguchi, Hiroshi Shima, Noriko Gotoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

Regenerative therapy　Vol. 1　p. 63-71　2015/06　Research paper (scientific journal)

[Metabolism enzyme controls cancer stemness].

Masamitsu Konno, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Nihon rinsho. Japanese journal of clinical medicine　Vol. 73　No. 5　p. 745-50　2015/05

Surgically resected human tumors reveal the biological significance of the gastric cancer stem cell markers CD44 and CD26.

Shimpei Nishikawa, Masamitsu Konno, Atsushi Hamabe, Shinichiro Hasegawa, Yoshihiro Kano, Takahito Fukusumi, Taroh Satoh, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Oncology letters　Vol. 9　No. 5　p. 2361-2367　2015/05　Research paper (scientific journal)

The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.

Hisataka Ogawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Jun Koseki, Koichi Kawamoto, Naohiro Nishida, Hugh Colvin, Akira Tomokuni, Yoshito Tomimaru, Naoki Hama, Hiroshi Wada, Shigeru Marubashi, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Molecular and clinical oncology　Vol. 3　No. 3　p. 563-571　2015/05　Research paper (scientific journal)

Novel markers of cancer stem cells in head and neck squamous cell carcinoma

T. Fukusumi, H. Ishii, J. Koseki, A. Hanamoto, S. Nakahara, Y. Yamamoto, H. Inohara

Cancer Cell & Microenvironment　Vol. 2　2015/04

Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer.

Jun Koseki, Hugh Colvin, Takahito Fukusumi, Naohiro Nishida, Masamitsu Konno, Koichi Kawamoto, Kenta Tsunekuni, Hidetoshi Matsui, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 46　No. 3　p. 1181-91　2015/03　Research paper (scientific journal)

RFPL4A Increases the G(1) Population and Decreases Sensitivity to Chemotherapy in Human Colorectal Cancer Cells

Atsushi Naito, Hirofumi Yamamoto, Yoshinori Kagawa, Yoko Naito, Daisuke Okuzaki, Keisuke Otani, Yoriko Iwamoto, Sakae Maeda, Junichi Kikuta, Keizo Nishikawa, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Masaru Ishii

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 10　p. 6326-6337　2015/03　Research paper (scientific journal)

System-wide analysis of the transcriptional network of human myelomonocytic leukemia cells predicts attractor structure and phorbol-ester-induced differentiation and dedifferentiation transitions

Katsumi Sakata, Hajime Ohyanagi, Shinji Sato, Hiroya Nobori, Akiko Hayashi, Hideshi Ishii, Carsten O. Daub, Jun Kawai, Harukazu Suzuki, Toshiyuki Saito

SCIENTIFIC REPORTS　Vol. 5　2015/02　Research paper (scientific journal)

Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.

Masamitsu Konno, Jun Koseki, Koichi Kawamoto, Naohiro Nishida, Hidetoshi Matsui, Dyah Laksmi Dewi, Miyuki Ozaki, Yuko Noguchi, Koshi Mimori, Noriko Gotoh, Nobuhiro Tanuma, Hiroshi Shima, Yuichiro Doki, Masaki Mori, Hideshi Ishii

PloS one　Vol. 10　No. 7　2015　Research paper (scientific journal)

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells.

Hisataka Ogawa, Xin Wu, Koichi Kawamoto, Naohiro Nishida, Masamitsu Konno, Jun Koseki, Hidetoshi Matsui, Kozou Noguchi, Noriko Gotoh, Tsuyoshi Yamamoto, Kanjiro Miyata, Nobuhiro Nishiyama, Hiroaki Nagano, Hirofumi Yamamoto, Satoshi Obika, Kazunori Kataoka, Yuichiro Doki, Masaki Mori, Hideshi Ishii

PloS one　Vol. 10　No. 5　2015　Research paper (scientific journal)

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity.

Keisuke Tamari, Kazuhiko Hayashi, Hideshi Ishii, Yoshihiro Kano, Masamitsu Konno, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Takahito Fukusumi, Shinichiro Hasegawa, Hisataka Ogawa, Atsushi Hamabe, Masaaki Miyo, Kozo Noguchi, Yuji Seo, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa

International journal of oncology　Vol. 45　No. 6　p. 2349-54　2014/12　Research paper (scientific journal)

Reprogramming using microRNA-302 improves drug sensitivity in hepatocellular carcinoma cells.

Chikato Koga, Shogo Kobayashi, Hiroaki Nagano, Yoshito Tomimaru, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Hidetoshi Eguchi, Masamitsu Konno, Hideshi Ishii, Koji Umeshita, Yuichiro Doki, Masaki Mori

Annals of surgical oncology　Vol. 21 Suppl 4　p. S591-600-600　2014/12　Research paper (scientific journal)

Visualization and characterization of cancer stem-like cells in cervical cancer.

Kazuhiko Hayashi, Keisuke Tamari, Hideshi Ishii, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Jun Koseki, Takahito Fukusumi, Yoshihiro Kano, Shimpei Nishikawa, Masaaki Miyo, Kozo Noguchi, Hisataka Ogawa, Atsushi Hamabe, Yuji Seo, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa

International journal of oncology　Vol. 45　No. 6　p. 2468-74　2014/12　Research paper (scientific journal)

Cancer stem cells of the digestive system.

Hugh S Colvin, Naohiro Nishida, Jun Koseki, Masamitsu Konno, Koichi Kawamoto, Kenta Tsunekuni, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Japanese journal of clinical oncology　Vol. 44　No. 12　p. 1141-9　2014/12　Research paper (scientific journal)

MACC1 expression levels as a novel prognostic marker for colorectal cancer

Hirofumi Yamamoto, Norikatsu Miyoshi, Koshi Mimori, Toshiki Hitora, Masayoshi Tokuoka, Shiki Fujino, Haley L. Ellis, Hideshi Ishii, Shingo Noura, Masayuki Ohue, Masahiko Yano, Yuichiro Doki, Masaki Mori

ONCOLOGY LETTERS　Vol. 8　No. 5　p. 2305-2309　2014/11　Research paper (scientific journal)

ANXA9 gene expression in colorectal cancer: A novel marker for prognosis

Norikatsu Miyoshi, Hirofumi Yamamoto, Koshi Mimori, Shinya Yamashita, Susumu Miyazaki, Sumiko Nakagawa, Hideshi Ishii, Shingo Noura, Masayuki Ohue, Masahiko Yano, Yuichiro Doki, Masaki Mori

ONCOLOGY LETTERS　Vol. 8　No. 5　p. 2313-2317　2014/11　Research paper (scientific journal)

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma, Hiroshi Shima, Kenta Tsunekuni, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Koshi Mimori, Noriko Gotoh, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Proceedings of the National Academy of Sciences of the United States of America　Vol. 111　No. 43　p. 15526-31　2014/10/28　Research paper (scientific journal)

胆道癌におけるSPARC発現の臨床的意義

中島 慎介, 小林 省吾, 坂井 大介, 富丸 慶人, 濱 直樹, 和田 浩志, 川本 弘一, 石井 秀始, 江口 英利, 梅下 浩司, 永野 浩昭, 土岐 祐一郎, 森 正樹

日本消化器外科学会雑誌　Vol. 47　No. Suppl.2　p. 252-252　2014/10

MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer

S. Hasegawa, H. Eguchi, H. Nagano, M. Konno, Y. Tomimaru, H. Wada, N. Hama, K. Kawamoto, S. Kobayashi, N. Nishida, J. Koseki, T. Nishimura, N. Gotoh, S. Ohno, N. Yabuta, H. Nojima, M. Mori, Y. Doki, H. Ishii

BRITISH JOURNAL OF CANCER　Vol. 111　No. 8　p. 1572-1580　2014/10　Research paper (scientific journal)

大腸癌先進部でのHexokinase 2とリン酸化型pyruvate dehydrogenase E1αの発現強度を複合解析することで予後不良群を鋭敏に予測できる

浜部 敦史, 山本 浩文, 今野 雅允, 植村 守, 西村 潤一, 畑 泰司, 竹政 伊知朗, 水島 恒和, 西田 尚弘, 川本 弘一, 小関 準, 土岐 祐一郎, 森 正樹, 石井 秀始

日本分子腫瘍マーカー研究会プログラム・講演抄録　Vol. 34回　p. 56-57　2014/09

プロテアソーム活性の低い甲状腺癌細胞は治療抵抗性・癌幹細胞の特質を持つ(Thyroid cancer cells with low proteasome activity have therapeutic resistance)

福角 隆仁, 石井 秀始, 今野 雅允, 西田 尚弘, 小関 準, 小川 久貴, 長谷川 慎一郎, 浜部 敦史, 林 和彦, 玉利 慶介, 土岐 祐一郎, 森 正樹, 猪原 秀典

日本癌学会総会記事　Vol. 73回　p. J-1033　2014/09

骨肉腫細胞中のプロテアソーム活性の低い集団は癌幹細胞様特性を持つ(A small fraction of osteosarcoma cells with low proteasome activity have cancer stem-like properties)

玉利 慶介, 石井 秀始, 林 和彦, 今野 雅允, 川本 弘一, 西田 尚弘, 小関 準, 加納 義浩, 福角 隆仁, 土岐 祐一郎, 森 正樹, 小川 和彦

日本癌学会総会記事　Vol. 73回　p. J-2087　2014/09

子宮頸癌における癌幹細胞の可視化に関する研究(Optical imaging of cancer stem-like cells in cervical cancer)

林 和彦, 石井 秀始, 玉利 慶介, 今野 雅充, 川本 弘一, 西田 尚弘, 小関 準, 加納 義浩, 福角 隆仁, 土岐 雄一郎, 森 正樹, 小川 和彦

日本癌学会総会記事　Vol. 73回　p. P-1171　2014/09

Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.

Atsushi Hamabe, Hirofumi Yamamoto, Masamitsu Konno, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Naohiro Nishida, Koichi Kawamoto, Jun Koseki, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Cancer science　Vol. 105　No. 9　p. 1100-8　2014/09　Research paper (scientific journal)

Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line.

Sakae Maeda, Hiroshi Wada, Yoko Naito, Hiroaki Nagano, Szandor Simmons, Yoshinori Kagawa, Atsushi Naito, Junichi Kikuta, Taeko Ishii, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Hidetoshi Eguchi, Koji Umeshita, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Masaru Ishii

The Journal of biological chemistry　Vol. 289　No. 34　p. 23786-95　2014/08/22　Research paper (scientific journal)

Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition.

Miho Okano, Masamitsu Konno, Yoshihiro Kano, Hirotoshi Kim, Koichi Kawamoto, Masahisa Ohkuma, Naotsugu Haraguchi, Takehiko Yokobori, Koshi Mimori, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 45　No. 2　p. 575-80　2014/08　Research paper (scientific journal)

【再生医療】脂肪由来間葉系幹細胞を用いた細胞療法の膵島移植への応用 CD90high脂肪由来間葉系幹細胞亜分画の有効性

川本 弘一, 今野 雅允, 石井 秀始, 富丸 慶人, 濱 直樹, 和田 浩志, 小林 省吾, 江口 英利, 種村 匡弘, 伊藤 壽記, 森 正樹, 土岐 祐一郎, 永野 浩昭

Organ Biology　Vol. 21　No. 2　p. 215-220　2014/07

CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma

T. Fukusumi, H. Ishii, M. Konno, T. Yasui, S. Nakahara, Y. Takenaka, Y. Yamamoto, S. Nishikawa, Y. Kano, H. Ogawa, S. Hasegawa, A. Hamabe, N. Haraguchi, Y. Doki, M. Mori, H. Inohara

BRITISH JOURNAL OF CANCER　Vol. 111　No. 3　p. 506-514　2014/07　Research paper (scientific journal)

Decreased miR-340 Expression in Bone Marrow Is Associated with Liver Metastasis of Colorectal Cancer

Hiroshi Takeyama, Hirofumi Yamamoto, Shinya Yamashita, Xin Wu, Hidekazu Takahashi, Junichi Nishimura, Naotsugu Haraguchi, Yasuhiro Miyake, Rei Suzuki, Kohei Murata, Masayuki Ohue, Takeshi Kato, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Koshi Mimori, Yuichiro Doki, Masaki Mori

MOLECULAR CANCER THERAPEUTICS　Vol. 13　No. 4　p. 976-985　2014/04　Research paper (scientific journal)

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

Yusuke Yoshioka, Nobuyoshi Kosaka, Yuki Konishi, Hideki Ohta, Hiroyuki Okamoto, Hikaru Sonoda, Ryoji Nonaka, Hirofumi Yamamoto, Hideshi Ishii, Masaki Mori, Koh Furuta, Takeshi Nakajima, Hiroshi Hayashi, Hajime Sugisaki, Hiroko Higashimoto, Takashi Kato, Fumitaka Takeshita, Takahiro Ochiya

NATURE COMMUNICATIONS　Vol. 5　2014/04　Research paper (scientific journal)

Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus.

Yoshihiro Kano, Masamitsu Konno, Koichi Kawamoto, Keisuke Tamari, Kazuhiko Hayashi, Takahito Fukusumi, Taroh Satoh, Shinji Tanaka, Kazuhiko Ogawa, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Oncology reports　Vol. 31　No. 3　p. 1133-8　2014/03　Research paper (scientific journal)

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation.

Yoshihiro Kano, Hideshi Ishii, Masamitsu Konno, Makoto Yamasaki, Hiroshi Miyata, Shimpei Nishikawa, Atsushi Hamabe, Hisataka Ogawa, Hidekazu Takahashi, Katsuya Ohta, Shinichiro Hasegawa, Kouji Tanaka, Takahito Fukusumi, Masahisa Otsuka, Koichi Kawamoto, Naotsugu Haraguchi, Rika Fujimoto, Masaharu Isobe, Yasuhiko Tomita, Nariaki Matsuura, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

International journal of oncology　Vol. 44　No. 2　p. 443-50　2014/02　Research paper (scientific journal)

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer

Francesca Lovat, Hideshi Ishii, Monica Schiappacassi, Matteo Fassan, Mattia Barbareschi, Enzo Galligioni, Pierluigi Gasparini, Gustavo Baldassarre, Carlo M. Croce, Andrea Vecchione

ONCOTARGET　Vol. 5　No. 4　p. 970-977　2014/02　Research paper (scientific journal)

Murine Insulinoma Cell-Conditioned Medium with ΒETA2/Neurod1 Transduction Efficiently Induces the Differentiation of Adipose-Derived Mesenchymal Stem Cells into β-Like Cells both In Vitro and In Vivo

K. Kawamoto, S. Yabe, M. Konno, H. Ishii, N. Nishida, J. Koseki, S. Fukuda, Y. Tomimaru, N. Hama, H. Wada, S. Kobayashi, H. Eguchi, M. Tanemura, T. Ito, E. Y. Lee, E. Mukai, T. Miki, Y. Doki, M. Mori, T. S. Hamazaki, H. Nagano, H. Okochi

Journal of Stem Cell Research & Therapy　Vol. 4　No. 8　2014　Research paper (scientific journal)

Significance of INHBA expression in human colorectal cancer.

Miho Okano, Hirofumi Yamamoto, Hisataka Ohkuma, Yoshihiro Kano, Hirotoshi Kim, Shimpei Nishikawa, Masamitsu Konno, Koichi Kawamoto, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Takehiko Yokobori, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Oncology reports　Vol. 30　No. 6　p. 2903-8　2013/12　Research paper (scientific journal)

Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo

Yoshinori Kagawa, Shinji Matsumoto, Yuji Kamioka, Koshi Mimori, Yoko Naito, Taeko Ishii, Daisuke Okuzaki, Naohiro Nishida, Sakae Maeda, Atsushi Naito, Junichi Kikuta, Keizo Nishikawa, Junichi Nishimura, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Michiyuki Matsuda, Akira Kikuchi, Masaki Mori, Masaru Ishii

PLOS ONE　Vol. 8　No. 12　2013/12　Research paper (scientific journal)

microRNAを用いた癌リプログラミングによる新規癌治療(An Innovative MicroRNA Mediated Cancer Reprogramming Therapy)

小川 久貴, 今野 雅充, 長谷川 慎一郎, 浜部 敦史, 西川 晋平, 加納 義浩, 福角 隆仁, 呉 しん, 宮崎 進, 山本 浩文, 土岐 祐一郎, 森 正樹, 石井 秀始

日本癌学会総会記事　Vol. 72回　p. 140-140　2013/10

食道扁平上皮癌におけるヒストンH3K4脱メチル化酵素JARID1Bの発現抑制効果(Histone H3K4 demethylase JARID1B off-target effects in esophageal squamous cell carcinoma cell lines)

加納 義浩, 今野 雅允, 西川 晋平, 福角 隆仁, 尾崎 みゆ希, 坂井 大介, 工藤 敏弘, 佐藤 太郎, 土岐 祐一郎, 森 正樹, 石井 秀始

日本癌学会総会記事　Vol. 72回　p. 335-335　2013/10

CD10(+)の頭頸部扁平上皮癌細胞は治療抵抗性であり、癌幹細胞の特質を持つ(CD10 positive head and neck squamous cell carcinoma have therapeutic resistant and cancer stem cell features)

福角 隆仁, 石井 秀始, 今野 雅允, 西川 晋平, 加納 義浩, 小川 久貴, 長谷川 慎一郎, 工藤 敏啓, 坂井 大介, 佐藤 太郎, 土岐 祐一郎, 森 正樹, 猪原 秀典

日本癌学会総会記事　Vol. 72回　p. 337-337　2013/10

胃癌においてCD44陽性および陰性分画に存在する癌幹細胞の研究(Both CD44 positive and negative populations of gastric cancer contain distinct cancer stem cell populations)

西川 晋平, 今野 雅允, 原口 直紹, 加納 義浩, 福角 隆仁, 太田 勝也, 工藤 敏啓, 坂井 大介, 瀧口 修司, 佐藤 太郎, 森 正樹, 土岐 祐一郎, 石井 秀始

日本癌学会総会記事　Vol. 72回　p. 337-337　2013/10

CD49f-positive cell population efficiently enriches colon cancer-initiating cells

Naotsugu Haraguchi, Hideshi Ishii, Koshi Mimori, Katsuya Ohta, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

International Journal of Oncology　Vol. 43　No. 2　p. 425-430　2013/08　Research paper (scientific journal)

Gene expression of bone morphogenic protein 8B in the primary site, peripheral blood and bone marrow of patients with gastric cancer

Kosuke Mima, Takeo Fukagawa, Junji Kurashige, Yuki Takano, Ryutaro Uchi, Hiroki Ueo, Tae Matsumura, Masahisa Ishibashi, Genta Sawada, Yusuke Takahashi, Sayuri Akiyoshi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Masayuki Watanabe, Hideshi Ishii, Masaki Mori, Hideo Baba, Mitsuru Sasako, Koshi Mimori

ONCOLOGY LETTERS　Vol. 6　No. 2　p. 387-392　2013/08　Research paper (scientific journal)

Effect of in vivo administration of reprogramming factors in the mouse liver.

Akira Tomokuni, Hidetoshi Eguchi, Hiromitsu Hoshino, Dyah Laksmi Dewi, Shinpei Nishikawa, Yoshihiro Kano, Norikatsu Miyoshi, Arinobu Tojo, Seiichiro Kobayashi, Noriko Gotoh, Kunihiko Hinohara, Noemi Fusaki, Toshiyuki Saito, Hiroshi Suemizu, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Masahiro Tanemura, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Hiroaki Nagano

Oncology letters　Vol. 6　No. 2　p. 323-328　2013/08　Research paper (scientific journal)

Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth.

Yoshihiro Kano, Masamitsu Konno, Katsuya Ohta, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshinori Kagawa, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Takahito Fukusumi, Yuko Noguchi, Miyuki Ozaki, Toshihiro Kudo, Daisuke Sakai, Taroh Satoh, Masaru Ishii, Eiichi Mizohata, Takeshi Inoue, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Molecular and clinical oncology　Vol. 1　No. 4　p. 753-757　2013/07　Research paper (scientific journal)

Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer.

Daisaku Yamada, Shogo Kobayashi, Hiroshi Wada, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Hideshi Ishii, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

European journal of cancer (Oxford, England : 1990)　Vol. 49　No. 7　p. 1725-40　2013/05　Research paper (scientific journal)

Innovative cell-modifying technology targeting cancer stem cell.

Hideshi Ishii, Masamitsu Konno, Yoshinori Kagawa, Sakae Maeda, Katsuya Ohta, Yoshihiro Kano, Shimpei Nishikawa, Taroh Satoh, Yuichiro Doki, Masaki Mori

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 54　No. 5　p. 415-22　2013/05　Research paper (scientific journal)

がん幹細胞を支えるニッチ

加納 義浩, 石井 秀始, 今野 雅允, 太田 勝也, 西川 晋平, 福角 隆仁, 浜部 敦志, 長谷川 慎一郎, 小川 久貴, 尾崎 みゆ希, 野口 裕子, 坂井 大介, 原口 直紹, 工藤 敏啓, 佐藤 太郎, 土岐 祐一郎, 森 正樹

癌と化学療法　Vol. 40　No. 4　p. 419-423　2013/04

The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer.

Yasushi Takatsuno, Koshi Mimori, Ken Yamamoto, Tetsuya Sato, Atsushi Niida, Hiroshi Inoue, Seiya Imoto, Shuhei Kawano, Rui Yamaguchi, Hiroyuki Toh, Hisae Iinuma, Shinya Ishimaru, Hideshi Ishii, Sadao Suzuki, Shinkan Tokudome, Masahiko Watanabe, Jun-Ichi Tanaka, Shin-Ei Kudo, Hidetaka Mochizuki, Masato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Satoru Miyano, Kenichi Sugihara, Masaki Mori

Annals of surgical oncology　Vol. 20　No. 4　p. 1395-402　2013/04　Research paper (scientific journal)

[Cancer stem cells depend on their own niche].

Yoshihiro Kano, Hideshi Ishii, Masamitsu Konno, Katsuya Ohta, Shimpei Nishikawa, Takahito Fukusumi, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Miyuki Ozaki, Yuko Noguchi, Daisuke Sakai, Naotsugu Haraguchi, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori

Gan to kagaku ryoho. Cancer & chemotherapy　Vol. 40　No. 4　p. 419-23　2013/04　Research paper (scientific journal)

Adipose-derived mesenchymal stem cells and regenerative medicine.

Masamitsu Konno, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Takahito Fukusumi, Shimpei Nishikawa, Katsuya Ohta, Yoshihiro Kano, Miyuki Ozaki, Yuko Noguchi, Daisuke Sakai, Toshihiro Kudoh, Koichi Kawamoto, Hidetoshi Eguchi, Taroh Satoh, Masahiro Tanemura, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Development, growth & differentiation　Vol. 55　No. 3　p. 309-18　2013/04　Research paper (scientific journal)

Depletion of JARID1B induces cellular senescence in human colorectal cancer.

Katsuya Ohta, Naotsugu Haraguchi, Yoshihiro Kano, Yoshinori Kagawa, Masamitsu Konno, Shimpei Nishikawa, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Takahito Fukusumi, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Yuko Noguchi, Miyuki Ozaki, Toshihiro Kudo, Daisuke Sakai, Taroh Satoh, Miwa Fukami, Masaru Ishii, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 42　No. 4　p. 1212-8　2013/04　Research paper (scientific journal)

Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy.

Shimpei Nishikawa, Masamitsu Konno, Atsushi Hamabe, Shinichiro Hasegawa, Yoshihiro Kano, Katsuya Ohta, Takahito Fukusumi, Daisuke Sakai, Toshihiro Kudo, Naotsugu Haraguchi, Taroh Satoh, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Hideshi Ishii

International journal of oncology　Vol. 42　No. 4　p. 1437-42　2013/04　Research paper (scientific journal)

Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

Takehiko Yokobori, Hisae Iinuma, Teppei Shimamura, Seiya Imoto, Keishi Sugimachi, Hideshi Ishii, Masaaki Iwatsuki, Daisuke Ota, Masahisa Ohkuma, Takeshi Iwaya, Naohiro Nishida, Ryunosuke Kogo, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hiroyuki Toh, Tetsuya Sato, Graham F. Barnard, Takeo Fukagawa, Seiichiro Yamamoto, Hayao Nakanishi, Shin Sasaki, Satoru Miyano, Toshiaki Watanabe, Hiroyuki Kuwano, Koshi Mimori, Klaus Pantel, Masaki Mori

CANCER RESEARCH　Vol. 73　No. 7　p. 2059-2069　2013/04　Research paper (scientific journal)

The REV7 Subunit of DNA Polymerase zeta Is Essential for Primordial Germ Cell Maintenance in the Mouse

Naoki Watanabe, Shinji Mii, Naoya Asai, Masato Asai, Kaoru Niimi, Kaori Ushida, Takuya Kato, Atsushi Enomoto, Hideshi Ishii, Masahide Takahashi, Yoshiki Murakumo

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 288　No. 15　p. 10459-10471　2013/04　Research paper (scientific journal)

がん幹細胞研究の最前線 消化器癌における癌幹細胞の特性と標的化

原口 直紹, 太田 勝也, 植村 守, 西村 潤一, 畑 泰司, 竹政 伊知朗, 水島 恒和, 山本 浩文, 石井 秀始, 土岐 祐一郎, 森 正樹

日本外科学会雑誌　Vol. 114　No. 臨増2　p. 292-292　2013/03

SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers

Yozo Suzuki, Naotsugu Haraguchi, Hidekazu Takahashi, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 42　No. 1　p. 161-167　2013/01　Research paper (scientific journal)

Eradication of therapy-resistant cancer cells in gastrointestinal organs.

Shimpei Nishikawa, Masamitsu Konno, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Yuko Noguchi, Miyuki Ozaki, Toshihiro Kudo, Daisuke Sakai, Naotsugu Haraguchi, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Molecular and clinical oncology　Vol. 1　No. 1　p. 15-17　2013/01

CD90- (Thy-1-) high selection enhances reprogramming capacity of murine adipose-derived mesenchymal stem cells.

Koichi Kawamoto, Masamitsu Konno, Hiroaki Nagano, Shimpei Nishikawa, Yoshito Tomimaru, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Shogo Kobayashi, Hidetoshi Eguchi, Masahiro Tanemura, Toshinori Ito, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Disease markers　Vol. 35　No. 5　p. 573-9　2013　Research paper (scientific journal)

microRNA-181a is associated with poor prognosis of colorectal cancer

Junichi Nishimura, Rio Handa, Hirofumi Yamamoto, Fumiaki Tanaka, Kohei Shibata, Koshi Mimori, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

ONCOLOGY REPORTS　Vol. 28　No. 6　p. 2221-2226　2012/12　Research paper (scientific journal)

[Esophageal cancer].

Taroh Satoh, Toshihiro Kudo, Daisuke Sakai, Naotsugu Haraguchi, Hideshi Ishii, Yuichiro Doki, Masaki Mori

Nihon rinsho. Japanese journal of clinical medicine　Vol. 70 Suppl 8　p. 434-7　2012/11　Research paper (scientific journal)

Biological and Clinical Availability of Adipose-Derived Stem Cells for Pelvic Dead Space Repair

Hidekazu Takahashi, Naotsugu Haraguchi, Shimpei Nishikawa, Susumu Miyazaki, Yozou Suzuki, Tsunekazu Mizushima, Junichi Nishimura, Ichirou Takemasa, Hirofumi Yamamoto, Koshi Mimori, Hideshi Ishii, Yuichiro Doki, Masaki Mori

STEM CELLS TRANSLATIONAL MEDICINE　Vol. 1　No. 11　p. 803-810　2012/11　Research paper (scientific journal)

Novel therapeutic target for cancer stem cells in hepatocellular carcinoma.

Hiroaki Nagano, Hideshi Ishii, Shigeru Marubashi, Naotsugu Haraguchi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori

Journal of hepato-biliary-pancreatic sciences　Vol. 19　No. 6　p. 600-5　2012/11　Research paper (scientific journal)

MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells

Naohiro Nishida, Shinya Yamashita, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 19　No. 9　p. 3065-3071　2012/09　Research paper (scientific journal)

Emerging Methods for Preparing iPS Cells

Susumu Miyazaki, Hirofumi Yamamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Yozo Suzuki, Naotsugu Haraguchi, Hideshi Ishii, Yuichiro Doki, Masaki Mori

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　Vol. 42　No. 9　p. 773-779　2012/09

Transcriptomic study of dormant gastrointestinal cancer stem cells.

Shimpei Nishikawa, Dyah Laksmi Dewi, Hideshi Ishii, Masamitsu Konno, Naotsugu Haraguchi, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Yuko Noguchi, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori

International journal of oncology　Vol. 41　No. 3　p. 979-84　2012/09　Research paper (scientific journal)

【臨床・創薬利用が見えてきたmicroRNA】(第2章)microRNA治療 miRNAによるiPS細胞作製と再生医療への展開

宮崎 進, 山本 浩文, 三吉 範克, 石井 秀始, 土岐 祐一郎, 森 正樹

遺伝子医学MOOK　No. 23　p. 188-192　2012/09

がん幹細胞の分子標的 癌幹細胞の細胞学的特性解析に基づく治療標的化(Molecular targeting to cancer stem cell/cancer initiating cell Cellular properties of cancer stem cells in gastroenterological cancer)

原口 直紹, 石井 秀始, 竹政 伊知朗, 水島 恒和, 西村 潤一, 植村 守, 池田 正孝, 山本 浩文, 関本 貢嗣, 永野 浩昭, 土岐 祐一郎, 森 正樹

日本癌学会総会記事　Vol. 71回　p. 48-48　2012/08

大腸癌における新規細胞周期関連細胞表面マーカーとしてのSSEA-3(SSEA-3 as a Novel Cancer Cell Cycle-Associated Marker in Colorectal Cancer)

鈴木 陽三, 山本 浩文, 植村 守, 西村 潤一, 竹政 伊知朗, 水島 恒和, 池田 正孝, 関本 貢嗣, 石井 秀始, 土岐 祐一郎, 森 正樹

日本癌学会総会記事　Vol. 71回　p. 239-239　2012/08

胃癌幹細胞の同定とその生物学的解析(Elucidation of biological significance of gastric cancer stem cells)

西川 晋平, 石井 秀始, 原口 直紹, 加納 義浩, 福角 隆仁, 尾崎 みゆ希, 今野 雅允, 瀧口 修司, 佐藤 太郎, 土岐 祐一郎, 森 正樹

日本癌学会総会記事　Vol. 71回　p. 96-96　2012/08

新規頭頸部扁平上皮癌幹細胞マーカーの検索(New candidates as cancer stem cell markers in head and neck squamous cell carcinoma)

福角 隆仁, 原口 直紹, 西川 晋平, 加納 義浩, 佐藤 太郎, 石井 秀始, 土岐 祐一郎, 森 正樹, 猪原 秀典

日本癌学会総会記事　Vol. 71回　p. 286-286　2012/08

食道扁平上皮癌においてヒストンH3K4脱メチル化酵素JARID1Bが増殖能、浸潤能を促進している(Histone H3K4 demethylase JARID1B promotes proliferation and invasion in esophageal squamous cell carcinoma)

加納 義浩, 石井 秀始, 原口 直紹, 福角 隆仁, 尾崎 みゆ希, 今野 雅允, 佐藤 太郎, 土岐 祐一郎, 森 正樹

日本癌学会総会記事　Vol. 71回　p. 387-388　2012/08

エピジェネティクスによる大腸癌幹細胞維持機構(Epigenetic Regulation Modulates Biological Behaviors of Colon Cancer Stem Cells)

太田 勝也, 原口 直紹, 賀川 義規, 加納 義浩, 西川 晋平, 福角 隆仁, 坂井 大介, 山本 浩文, 関本 貢嗣, 佐藤 太郎, 土岐 祐一郎, 森 正樹, 石井 秀始

日本癌学会総会記事　Vol. 71回　p. 420-420　2012/08

消化器がんの抗がん剤感受性を増感する新技術

西川 晋平, 佐藤 太郎, 今野 雅允, 原口 直紹, 加納 義浩, 福角 隆仁, 太田 勝也, 尾崎 みゆ希, 野口 裕子, 工藤 敏啓, 坂井 大介, 土岐 祐一郎, 森 正樹, 石井 秀始

がん分子標的治療　Vol. 10　No. 3　p. 210-215　2012/07

microRNA-based cancer cell reprogramming technology (Review)

Shimpei Nishikawa, Hideshi Ishii, Naotsugu Haraguchi, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Miyuki Ozaki, Dyah Laksmi Dewi, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

EXPERIMENTAL AND THERAPEUTIC MEDICINE　Vol. 4　No. 1　p. 8-14　2012/07　Research paper (scientific journal)

Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon.

Ho Min Kim, Naotsugu Haraguchi, Hideshi Ishii, Masahisa Ohkuma, Miho Okano, Koshi Mimori, Hidetoshi Eguchi, Hirofumi Yamamoto, Hiroaki Nagano, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Annals of surgical oncology　Vol. 19 Suppl 3　p. S539-48-48　2012/07　Research paper (scientific journal)

Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma.

Takehiko Yokobori, Koshi Mimori, Masaaki Iwatsuki, Hideshi Ishii, Fumiaki Tanaka, Tetsuya Sato, Hiroyuki Toh, Tomoya Sudo, Takeshi Iwaya, Yoichi Tanaka, Ichiro Onoyama, Hiroyuki Kuwano, Keiichi I Nakayama, Masaki Mori

International journal of oncology　Vol. 41　No. 1　p. 253-9　2012/07　Research paper (scientific journal)

Evolving FACS Technology FACSを応用した生体イメージング関連分子の解析

賀川 義規, 西川 恵三, 前田 栄, 菊田 順一, 太田 勝也, 西村 潤一, 竹政 伊知朗, 水島 恒和, 池田 正孝, 山本 浩文, 関本 貢嗣, 石井 秀始, 土岐 祐一郎, 森 正樹, 石井 優

Cytometry Research　Vol. 22　No. Suppl.　p. 46-46　2012/06

癌の細胞周期蛍光イメージングによる抗腫瘍薬の効果ポイントの可視化

賀川 義規, 前田 栄, 太田 勝也, 菊田 順一, 西川 恵三, 西村 潤一, 竹政 伊知朗, 水島 恒和, 池田 正孝, 山本 浩文, 関本 貢嗣, 石井 秀始, 土岐 祐一郎, 森 正樹, 石井 優

Cytometry Research　Vol. 22　No. Suppl.　p. 57-57　2012/06

FCMで免疫疾患を追い詰める 細胞外ATPによるマウス腸管固有粘膜層におけるTh17細胞誘導

西村 潤一, 竹田 潔, 植村 守, 竹政 伊知朗, 水島 恒和, 池田 政孝, 石井 秀始, 山本 浩文, 関本 貢嗣, 土岐 祐一郎, 森 政樹

Cytometry Research　Vol. 22　No. Suppl.　p. 41-41　2012/06

癌幹細胞 固形腫瘍 エピジェネティクスによる大腸癌幹細胞維持機構

太田 勝也, 原口 直紹, 賀川 義規, 加納 義浩, 西川 晋平, 福角 隆仁, 坂井 大介, 西村 潤一, 水島 恒和, 山本 浩文, 関本 貢嗣, 佐藤 太郎, 土岐 祐一郎, 森 正樹, 石井 秀始

Cytometry Research　Vol. 22　No. Suppl.　p. 42-42　2012/06

胃癌における癌幹細胞の同定と生物学的解析

西川 晋平, 石井 秀始, 原口 直紹, 加納 義浩, 福角 隆仁, 太田 勝也, 坂井 大介, 佐藤 太郎, 瀧口 修司, 土岐 祐一郎, 森 正樹

Cytometry Research　Vol. 22　No. Suppl.　p. 54-54　2012/06

Genetic alteration of stemness factors and p53 in mouse forestomach by chemical carcinogen-induced carcinogenesis

Kazuyoshi Yamamoto, Hideshi Ishii, Jeong Ho Moon, Naotsugu Haraguchi, Yuichiro Doki, Masaki Mori

ONCOLOGY LETTERS　Vol. 3　No. 6　p. 1216-1220　2012/06　Research paper (scientific journal)

Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells

Shimpei Nishikawa, Hideshi Ishii, Naotsugu Haraguchi, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

EXPERIMENTAL AND THERAPEUTIC MEDICINE　Vol. 3　No. 6　p. 959-962　2012/06　Research paper (scientific journal)

Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells

Dyah Laksmi Dewi, Hideshi Ishii, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshihiro Kano, Takahito Fukusumi, Miyuki Ozaki, Toshiyuki Saito, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 29　No. 6　p. 1060-1064　2012/06　Research paper (scientific journal)

Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters

Naohiro Nishida, Makoto Nagahara, Tetsuya Sato, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Kenichi Sugihara, Yuichiro Doki, Masaki Mori

CLINICAL CANCER RESEARCH　Vol. 18　No. 11　p. 3054-3070　2012/06　Research paper (scientific journal)

抗体アレイを用いた、新たな頭頸部癌幹細胞マーカーの検討

福角 隆仁, 石井 秀始, 森 正樹, 猪原 秀典

頭頸部癌　Vol. 38　No. 2　p. 185-185　2012/05

Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance

Yojiro Hashiguchi, Naohiro Nishida, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Hidetaka Mochizuki, Kazuo Hase, Yuichiro Doki, Masaki Mori

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 40　No. 5　p. 1477-1482　2012/05　Research paper (scientific journal)

Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer.

Hiromitsu Hoshino, Hiroaki Nagano, Naotsugu Haraguchi, Shimpei Nishikawa, Akira Tomokuni, Yoshihiro Kano, Takahito Fukusumi, Toshiyuki Saito, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hidetoshi Eguchi, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

International journal of oncology　Vol. 40　No. 5　p. 1423-30　2012/05　Research paper (scientific journal)

Absence of CD71 Transferrin Receptor Characterizes Human Gastric Adenosquamous Carcinoma Stem Cells

Masahisa Ohkuma, Naotsugu Haraguchi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Ho Min Kim, Miho Shimomura, Hajime Hirose, Katsuhiko Yanaga, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 19　No. 4　p. 1357-1364　2012/04　Research paper (scientific journal)

[The concept and significance of cancer stem cells].

Naotsugu Haraguchi, Hideshi ishii, Daisuke Sakai, Taroh Satoh, Yuichirou Doki, Masaki Mori

Nihon Geka Gakkai zasshi　Vol. 113　No. 2　p. 204-9　2012/03　Research paper (scientific journal)

Reprogramming of gastrointestinal cancer cells.

DyahLaksmi Dewi, Hideshi Ishii, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Susumu Miyazaki, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

Cancer science　Vol. 103　No. 3　p. 393-9　2012/03　Research paper (scientific journal)

Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma

H. Miyagaki, M. Yamasaki, H. Miyata, T. Takahashi, Y. Kurokawa, K. Nakajima, S. Takiguchi, Y. Fujiwara, H. Ishii, F. Tanaka, M. Mori, Y. Doki

BRITISH JOURNAL OF CANCER　Vol. 106　No. 5　p. 947-954　2012/02　Research paper (scientific journal)

MicroRNA-372 Is Associated with Poor Prognosis in Colorectal Cancer

Shinya Yamashita, Hirofumi Yamamoto, Koshi Mimori, Naohiro Nishida, Hidekazu Takahashi, Naotsugu Haraguchi, Fumiaki Tanaka, Kohei Shibata, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori

ONCOLOGY　Vol. 82　No. 4　p. 205-212　2012　Research paper (scientific journal)

Expression of CLDN1 in colorectal cancer: A novel marker for prognosis

Sumiko Nakagawa, Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 39　No. 4　p. 791-796　2011/10　Research paper (scientific journal)

The Significance of PITX2 Overexpression in Human Colorectal Cancer

Hajime Hirose, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 18　No. 10　p. 3005-3012　2011/10　Research paper (scientific journal)

造血幹細胞移植後のドナー由来固形腫瘍(Solid tumor is derived from donor cells after HSCT)

加納 義浩, 石井 秀始, 山崎 誠, 宮田 博志, 原口 直紹, 西川 晋平, Dewi DyahLaksmi, 坂井 大介, 佐藤 太郎, 松浦 成昭, 磯部 正治, 土岐 祐一郎, 森 正樹

日本癌学会総会記事　Vol. 70回　p. 212-213　2011/09

Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity

Kenta Moriwaki, Kumiko Okudo, Naotsugu Haraguchi, Shunsaku Takeishi, Hiromichi Sawaki, Hisashi Narimatsu, Masahiro Tanemura, Hideshi Ishii, Masaki Mori, Eiji Miyoshi

CANCER SCIENCE　Vol. 102　No. 6　p. 1164-1170　2011/06　Research paper (scientific journal)

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

Norikatsu Miyoshi, Hideshi Ishii, Hiroaki Nagano, Naotsugu Haraguchi, Dyah Laksmi Dewi, Yoshihiro Kano, Shinpei Nishikawa, Masahiro Tanemura, Koshi Mimori, Fumiaki Tanaka, Toshiyuki Saito, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

CELL STEM CELL　Vol. 8　No. 6　p. 633-638　2011/06　Research paper (scientific journal)

MicroRNA-125a-5p Is an Independent Prognostic Factor in Gastric Cancer and Inhibits the Proliferation of Human Gastric Cancer Cells in Combination with Trastuzumab

Naohiro Nishida, Koshi Mimori, Muller Fabbri, Takehiko Yokobori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Yuichiro Doki, Masaki Mori

CLINICAL CANCER RESEARCH　Vol. 17　No. 9　p. 2725-2733　2011/05　Research paper (scientific journal)

MicroRNA miR-125b is a prognostic marker in human colorectal cancer

Naohiro Nishida, Takehiko Yokobori, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Yuichiro Doki, Hiroyuki Kuwano, Masaki Mori

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 38　No. 5　p. 1437-1443　2011/05　Research paper (scientific journal)

Significance of Lgr5(+ve) Cancer Stem Cells in the Colon and Rectum

Hidekazu Takahashi, Hideshi Ishii, Naohiro Nishida, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Takehiko Yokobori, Koshi Mimori, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 18　No. 4　p. 1166-1174　2011/04　Research paper (scientific journal)

Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients.

Daisuke Ota, Koshi Mimori, Takehiko Yokobori, Masaaki Iwatsuki, Akemi Kataoka, Norikazu Masuda, Hideshi Ishii, Shinji Ohno, Masaki Mori

International journal of oncology　Vol. 38　No. 4　p. 955-62　2011/04　Research paper (scientific journal)

The future prospects and subject of the liver cancer stem cells study for the clinical application.

Naotsugu Haraguchi, Hideshi Ishii, Hideaki Nagano, Yuichiro Doki, Masaki Mori

Gastroenterology　2011/02/23　Research paper (scientific journal)

FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma

Naohiro Nishida, Koshi Mimori, Takehiko Yokobori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 18　No. 2　p. 535-542　2011/02　Research paper (scientific journal)

How does tumor suppressor FHIT modulate oxidative stress and DNA damage checkpoints in early cancer?

Hideshi Ishii, Toshiyuki Saito

Tumor Suppressors　p. 243-251　2011/01　Part of collection (book)

Cancer Stem Cell Research: Present Status and Future Perspectives

Kano Yoshihiro, Nishikawa Shimpei, Dewi Dyah Laksmi, Ishii Hideshi, Doki Yuuichirou, Mori Masaki

The Journal of the Japan Broncho-esophagological Society　Vol. 62　No. 2　p. 71-79　2011

Role of microRNAs in solid tumors

Rie Hamano, Hideshi Ishii, Hiroshi Miyata, Yuichiro Doki, Masaki Mori

Journal of Nucleic Acids Investigation　Vol. 2　No. 1　p. 5-16　2011　Research paper (scientific journal)

Therapy-resistant Gastrointestinal Cancer Stem Cells

Masaki Mori, Naotsugu Haraguchi, Dewi Dyah Laksmi, Yoshihiro Kano, Shinpei Nishikawa, Koshi Mimori, Yuichiro Doki, Hideshi Ishii

9TH INTERNATIONAL GASTRIC CANCER CONGRESS (IGCC 2011): A GATE TO THE FUTURE OF GASTRIC CANCER TREATMENT　p. 39-46　2011　Research paper (international conference proceedings)

STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma.

Yoshiaki Kita, Koshi Mimori, Masaaki Iwatsuki, Takehiko Yokobori, Keisuke Ieta, Fumiaki Tanaka, Hideshi Ishii, Hiroshi Okumura, Shoji Natsugoe, Masaki Mori

Annals of surgical oncology　Vol. 18　No. 1　p. 261-72　2011/01　Research paper (scientific journal)

[Cancer stem cells in solid tumors].

Hajime Hirose, Hirofumi Yamamoto, Norikatsu Miyoshi, Mamoru Uemura, Susumu Miyazaki, Hidekazu Takahashi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Gan to kagaku ryoho. Cancer & chemotherapy　Vol. 37　No. 13　p. 2809-12　2010/12　Research paper (scientific journal)

Serum matrix-metalloproteinase-1 is a bona fide prognostic marker for colorectal cancer.

Kouichirou Tahara, Koshi Mimori, Hisae Iinuma, Masaaki Iwatsuki, Takehiko Yokobori, Hideshi Ishii, Hideaki Anai, Seigo Kitano, Masaki Mori

Annals of surgical oncology　Vol. 17　No. 12　p. 3362-9　2010/12　Research paper (scientific journal)

固形癌の癌幹細胞

廣瀬 創, 山本 浩文, 三吉 範克, 植村 守, 宮崎 進, 高橋 秀和, 竹政 伊知朗, 水島 恒和, 池田 正孝, 石井 秀始, 関本 貢嗣, 土岐 祐一郎, 森 正樹

癌と化学療法　Vol. 37　No. 13　p. 2809-2812　2010/12

Abnormal Expression of PFDN4 in Colorectal Cancer: A Novel Marker for Prognosis

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Naohiro Nishida, Masayoshi Tokuoka, Hirofumi Akita, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 17　No. 11　p. 3030-3036　2010/11　Research paper (scientific journal)

Clinical significance of ASB9 in human colorectal cancer

Masayoshi Tokuoka, Norikatsu Miyoshi, Toshiki Hitora, Koshi Mimori, Fumiaki Tanaka, Koichi Shibata, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 37　No. 5　p. 1105-1111　2010/11　Research paper (scientific journal)

集学的治療にて長期生存中のVirchowリンパ節転移を伴った直腸癌の1例

廣瀬 創, 池田 正孝, 三吉 範克, 金 浩敏, 岡野 美穂, 植村 守, 山下 晋也, 竹政 伊知朗, 水島 恒和, 山本 浩文, 石井 秀始, 関本 貢嗣, 土岐 祐一郎, 森 正樹

癌と化学療法　Vol. 37　No. 12　p. 2545-2547　2010/11

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles

Fumiaki Tanaka, Ken Yamamoto, Sadao Suzuki, Hiroshi Inoue, Masahiko Tsurumaru, Yoshiaki Kajiyama, Hoichi Kato, Hiroyasu Igaki, Koh Furuta, Hiromasa Fujita, Toshiaki Tanaka, Yoichi Tanaka, Yoshiyuki Kawashima, Shoji Natsugoe, Tetsuro Setoyama, Shinkan Tokudome, Koshi Mimori, Naotsugu Haraguchi, Hideshi Ishii, Masaki Mori

GUT　Vol. 59　No. 11　p. 1457-1464　2010/11　Research paper (scientific journal)

Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer.

Takehiko Yokobori, Koshi Mimori, Hideshi Ishii, Masaaki Iwatsuki, Fumiaki Tanaka, Yukio Kamohara, Keisuke Ieta, Yoshiaki Kita, Yuichiro Doki, Hiroyuki Kuwano, Masaki Mori

Annals of surgical oncology　Vol. 17　No. 10　p. 2601-7　2010/10　Research paper (scientific journal)

Risk factors for postoperative delirium in elderly patients with colorectal cancer

Mitsuyoshi Tei, Masataka Ikeda, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES　Vol. 24　No. 9　p. 2135-2139　2010/09　Research paper (scientific journal)

Correlated Expression of CD47 and SIRPA in Bone Marrow and in Peripheral Blood Predicts Recurrence in Breast Cancer Patients

Makoto Nagahara, Koshi Mimori, Akemi Kataoka, Hideshi Ishii, Fumiaki Tanaka, Tsuyoshi Nakagawa, Takanobu Sato, Shinji Ono, Kenichi Sugihara, Masaki Mori

CLINICAL CANCER RESEARCH　Vol. 16　No. 18　p. 4625-4635　2010/09　Research paper (scientific journal)

The clinical significance of vimentin-expressing gastric cancer cells in bone marrow.

Masaaki Iwatsuki, Koshi Mimori, Takeo Fukagawa, Hideshi Ishii, Takehiko Yokobori, Mitsuru Sasako, Hideo Baba, Masaki Mori

Annals of surgical oncology　Vol. 17　No. 9　p. 2526-33　2010/09　Research paper (scientific journal)

CD13 is a therapeutic target in human liver cancer stem cells

Naotsugu Haraguchi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Masahisa Ohkuma, Ho Min Kim, Hirofumi Akita, Daisuke Takiuchi, Hisanori Hatano, Hiroaki Nagano, Graham F. Barnard, Yuichiro Doki, Masaki Mori

JOURNAL OF CLINICAL INVESTIGATION　Vol. 120　No. 9　p. 3326-3339　2010/09　Research paper (scientific journal)

[Development of cancer stem cell research in gastrointestinal tumors].

Hideshi Ishii, Norikatsu Miyoshi, Naotsugu Haraguchi, Yuichiro Doki, Masaki Mori

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 51　No. 8　p. 672-8　2010/08　Research paper (scientific journal)

Cancer Stem Cell 腫瘍幹細胞研究の消化器癌への展開

石井 秀始, 三吉 範克, 原口 直紹, 土岐 祐一郎, 森 正樹

臨床血液　Vol. 51　No. 8　p. 672-678　2010/08

Properties and identification of cancer stem cells: A changing insight into intractable cancer

Norikatsu Miyoshi, Hideshi Ishii, Mitsugu Sekimoto, Naotsugu Haraguchi, Yuichiro Doki, Masaki Mori

SURGERY TODAY　Vol. 40　No. 7　p. 608-613　2010/07

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance.

Masaaki Iwatsuki, Koshi Mimori, Hideshi Ishii, Takehiko Yokobori, Yasushi Takatsuno, Tetsuya Sato, Hiroyuki Toh, Ichiro Onoyama, Keiichi I Nakayama, Hideo Baba, Masaki Mori

International journal of cancer　Vol. 126　No. 8　p. 1828-1837　2010/04/15　Research paper (scientific journal)

Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells

Ken-ichi Nagai, Hideshi Ishii, Norikatsu Miyoshi, Hiromitsu Hoshino, Toshiyuki Saito, Tetsuya Sato, Yoshito Tomimaru, Shogo Kobayashi, Hiroaki Nagano, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 395　No. 2　p. 258-263　2010/04　Research paper (scientific journal)

TGM2 Is a Novel Marker for Prognosis and Therapeutic Target in Colorectal Cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Toshiki Hitora, Mitsuyoshi Tei, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 17　No. 4　p. 967-972　2010/04　Research paper (scientific journal)

TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 36　No. 3　p. 563-568　2010/03　Research paper (scientific journal)

大腸癌の分子生物学 大腸癌細胞を初期化したときにどうなるか

三吉 範克, 石井 秀始, 星野 宏光, 永井 健一, 原口 直紹, 土岐 祐一郎, 森 正樹

大腸癌Frontier　Vol. 3　No. 1　p. 69,5-73,5　2010/03

SCRN1 Is a Novel Marker for Prognosis in Colorectal Cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

JOURNAL OF SURGICAL ONCOLOGY　Vol. 101　No. 2　p. 156-159　2010/02　Research paper (scientific journal)

ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Kennichi Nagai, Mamoru Uemura, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ONCOLOGY REPORTS　Vol. 23　No. 2　p. 505-510　2010/02　Research paper (scientific journal)

癌幹細胞研究と治療への応用

森 正樹, 三吉 範克, 原口 直紹, 石井 秀始

日本分子腫瘍マーカー研究会誌　Vol. 25　p. 11-12　2010/02

Epithelial-mesenchymal transition in cancer development and its clinical significance

Masaaki Iwatsuki, Koshi Mimori, Takehiko Yokobori, Hideshi Ishi, Toru Beppu, Shoji Nakamori, Hideo Baba, Masaki Mori

CANCER SCIENCE　Vol. 101　No. 2　p. 293-299　2010/02

A long-term survival case of rectal cancer with virchow's lymph node metastasis by multimodality therapy

Hajime Hirose, Masataka Ikeda, Norikatsu Miyoshi, Ho Min Kim, Miho Okano, Mamoru Uemura, Shinya Yamashita, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Japanese Journal of Cancer and Chemotherapy　Vol. 37　No. 12　p. 2545-2547　2010　Research paper (scientific journal)

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA

H. Tanooka, K. Tatsumi, H. Tsuji, Y. Noda, T. Katsube, H. Ishii, A. Ootsuyama, F. Takeshita, T. Ochiya

Cancer Gene Therapy　Vol. 17　No. 1　p. 1-10　2010/01　Research paper (scientific journal)

Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors

Hajime Hirose, Hideshi Ishii, Koshi Mimori, Daisuke Ohta, Masahisa Ohkuma, Hirohiko Tsujii, Toshiyuki Saito, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ONCOLOGY REPORTS　Vol. 23　No. 1　p. 35-43　2010/01　Research paper (scientific journal)

FHIT suppresses inflammatory carcinogenic activity by inducing apoptosis in esophageal epithelial cells

Koshi Mimori, Takehiko Yokobori, Masaaki Iwatsuki, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Masaki Mori

Journal of Nucleic Acids Investigation　Vol. 1　No. 1　p. 31-35　2010　Research paper (scientific journal)

Defined factors induce reprogramming of gastrointestinal cancer cells

Norikatsu Miyoshi, Hideshi Ishii, Ken-ichi Nagai, Hiromitsu Hoshino, Koshi Mimori, Fumiaki Tanaka, Hiroaki Nagano, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 1　p. 40-45　2010/01　Research paper (scientific journal)

RGS16 Is a Marker for Prognosis in Colorectal Cancer

Norikatsu Miyoshi, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 16　No. 12　p. 3507-3514　2009/12　Research paper (scientific journal)

Postoperative Complications in Elderly Patients With Colorectal Cancer Comparison of Open and Laparoscopic Surgical Procedures

Mitsuyoshi Tei, Masataka Ikeda, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Hideshi Ishii, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES　Vol. 19　No. 6　p. 488-492　2009/12　Research paper (scientific journal)

Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer

Hiromitsu Hoshino, Norikatsu Miyoshi, Ken-ichi Nagai, Yoshito Tomimaru, Hiroaki Nagano, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 390　No. 3　p. 1061-1065　2009/12　Research paper (scientific journal)

Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis

N. Miyoshi, H. Ishii, K. Mimori, Y. Takatsuno, H. Kim, H. Hirose, M. Sekimoto, Y. Doki, M. Mori

BRITISH JOURNAL OF CANCER　Vol. 101　No. 10　p. 1664-1670　2009/11　Research paper (scientific journal)

Cancer stem cells in gastrointestinal carcinomas

Hirofumi Yamamoto, Naotsugu Haraguchi, Masahisa Ohkuma, Hideshi Ishii, Yuichiro Doki, Masaki Mori

Biotherapy　Vol. 23　No. 5　p. 386-392　2009/09　Research paper (scientific journal)

【消化管疾患 診断と治療の進歩】治療法の進歩 大腸癌に対する化学療法、分子標的治療

植村 守, 山本 浩文, 原口 直紹, 竹政 伊知朗, 水島 恒和, 池田 正孝, 石井 秀始, 関本 貢嗣, 土岐 祐一郎, 森 正樹

綜合臨床　Vol. 58　No. 9　p. 1965-1971　2009/09

What's New in SURGERY FRONTIER 幹細胞をめぐる話題 癌幹細胞に対するニッチの役割を知る

植村 守, 石井 秀始, 原口 直紹, 関本 貢嗣, 土岐 祐一郎, 森 正樹

Surgery Frontier　Vol. 16　No. 3　p. 346-350　2009/09

Comprehensive Analysis of the Clinical Significance of Inducing Pluripotent Stemness-Related Gene Expression in Colorectal Cancer Cells

Yasumitsu Saiki, Shinya Ishimaru, Koshi Mimori, Yasushi Takatsuno, Makoto Nagahara, Hideshi Ishii, Kazutaka Yamada, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 16　No. 9　p. 2638-2644　2009/09　Research paper (scientific journal)

腫瘍マーカーの新しい地平を拓く 癌幹細胞研究と治療への応用

森 正樹, 三吉 範克, 原口 直紹, 石井 秀始

日本分子腫瘍マーカー研究会プログラム・講演抄録　Vol. 29回　p. 26-27　2009/09

Prevention of Severe Pelvic Abscess Formation Following Extended Radical Surgery for Locally Recurrent Rectal Cancer

Mamoru Uemura, Masataka Ikeda, Mitsugu Sekimoto, Naotsugu Haraguchi, Tsunekazu Mizushima, Hirofumi Yamamoto, Ichiro Takemasa, Hideshi Ishii, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 16　No. 8　p. 2204-2210　2009/08　Research paper (scientific journal)

[Perspectives on current status and future directions for cancer stem cells theory in gastrointestinal cancer].

Ichiro Takemasa, Hideshi Ishii, Naotsugu Haraguchi, Koshi Mimori, Fumiaki Tanaka, Hiroaki Nagano, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Nihon Geka Gakkai zasshi　Vol. 110　No. 4　p. 207-12　2009/07　Research paper (scientific journal)

Preoperative u-PAR Gene Expression in Bone Marrow Indicates the Potential Power of Recurrence in Breast Cancer Cases

Koshi Mimori, Akemi Kataoka, Hiroshi Yamaguchi, Norikazu Masuda, Yoshimasa Kosaka, Hideshi Ishii, Shinji Ohno, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 16　No. 7　p. 2035-2041　2009/07　Research paper (scientific journal)

Fragile gene product, Fhit, in oxidative and replicative stress responses

Hiroshi Okumura, Hideshi Ishii, Flavia Pichiorri, Carlo M. Croce, Masaki Mori, Kay Huebner

CANCER SCIENCE　Vol. 100　No. 7　p. 1145-1150　2009/07

Bone marrow and peripheral blood expression of ID1 in human gastric carcinoma patients is a bona fide indicator of lymph node and peritoneal metastasis

M. Iwatsuki, T. Fukagawa, K. Mimori, H. Nakanishi, S. Ito, H. Ishii, T. Yokobori, M. Sasako, H. Baba, M. Mori

BRITISH JOURNAL OF CANCER　Vol. 100　No. 12　p. 1937-1942　2009/06　Research paper (scientific journal)

p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.

Takehiko Yokobori, Koshi Mimori, Masaaki Iwatsuki, Hideshi Ishii, Ichiro Onoyama, Takeo Fukagawa, Hiroyuki Kuwano, Keiichi I Nakayama, Masaki Mori

Cancer research　Vol. 69　No. 9　p. 3788-94　2009/05/01　Research paper (scientific journal)

【病態の理解と治療をめざす 癌と微小環境 癌幹細胞、浸潤・転移、血管新生のメカニズムと環境応答を標的とした治療・創薬の新展開】癌幹細胞 抗癌剤耐性のメカニズム 特に癌幹細胞の観点から

三吉 範克, 石井 秀始, 森 正樹

実験医学　Vol. 27　No. 2　p. 200-205　2009/02

Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment

Koshi Mimori, Hideshi Ishii, Hiroshi Inoue, Graham F. Barnard, Masaki Mori

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　Vol. 23　p. S205-S209　2008/12　Research paper (scientific journal)

A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.

Koshi Mimori, Takeo Fukagawa, Yoshimasa Kosaka, Kenji Ishikawa, Masaaki Iwatsuki, Takehiko Yokobori, Shigeo Hirasaki, Yasushi Takatsuno, Hiroyuki Sakashita, Hideshi Ishii, Mitsuru Sasako, Masaki Mori

Annals of surgical oncology　Vol. 15　No. 10　p. 2934-42　2008/10　Research paper (scientific journal)

Cancer stem cells and chemoradiation resistance

Hideshi Ishii, Masaaki Iwatsuki, Keisuke Ieta, Daisuke Ohta, Naotsugu Haraguchi, Koshi Mimori, Masaki Mori

CANCER SCIENCE　Vol. 99　No. 10　p. 1871-1877　2008/10

【肝幹細胞をめぐる最近の知見】肝幹細胞とtumor-initiating cells 消化器癌と癌幹細胞

三吉 範克, 石井 秀始, 原口 直紹, 大熊 誠尚, 永野 浩昭, 土岐 祐一郎, 森 正樹

肝・胆・膵　Vol. 57　No. 3　p. 413-419　2008/09

Molecular parameters of genome instability: Roles of fragile genes at common fragile sites

Flavia Pichiorri, Hideshi Ishii, Hiroshi Okumura, Francesco Trapass, Ya Wang, Kay Huebner

JOURNAL OF CELLULAR BIOCHEMISTRY　Vol. 104　No. 5　p. 1525-1533　2008/08　Research paper (scientific journal)

Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes

Hideshi Ishii, Koshi Mimori, Kazuhiro Ishikawa, Hiroshi Okumura, Flavia Pichiorri, Teresa Druck, Hiroshi Inoue, Andrea Vecchione, Toshiyuki Saito, Masaki Mori, Kay Huebner

CANCER RESEARCH　Vol. 68　No. 10　p. 3662-3670　2008/05　Research paper (scientific journal)

Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis

Raffaele Baffa, Matteo Fassan, Cinzia Sevignani, Andrea Vecchione, Hideshi Ishii, Enrico Giarnieri, Renato V. Iozzo, Leonard G. Gomella, Carlo M. Croce

CARCINOGENESIS　Vol. 29　No. 4　p. 846-848　2008/04　Research paper (scientific journal)

Cancer metastasis as disrupted developmental phenotype

Hideshi Ishii, Toshiyuki Saito

CURRENT GENOMICS　Vol. 9　No. 1　p. 25-28　2008/03　Research paper (scientific journal)

Recent progress of radiation research: Cancer stem cells and ncRNAs

Hideshi Ishi, Toshiyuki Saito

Stem Cell Applications in Diseases　p. 11-21　2008　Part of collection (book)

Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells

Hirofumi Yamamoto, Shingo Noura, Jiro Okami, Mamoru Uemura, Ichiro Takemasa, Masataka Ikeda, Hideshi Ishii, Mitsugu Sekimoto, Nariaki Matsuura, Morito Monden, Masaki Mori

International Journal of Molecular Medicine　Vol. 22　No. 6　p. 757-761　2008　Research paper (scientific journal)

Modulation of DNA damage checkpoint; patenting and possible application for cancer medicine

Kazuhiro Ishikawa, Hideshi Ishii, Keiichi Ichimura

Recent Patents on DNA and Gene Sequences　Vol. 2　No. 1　p. 34-39　2008/01　Research paper (scientific journal)

Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer

M. Ohta, K. Mimori, Y. Fukuyoshi, Y. Kita, K. Motoyama, K. Yamashita, H. Ishii, H. Inoue, M. Mori

BRITISH JOURNAL OF CANCER　Vol. 98　No. 2　p. 410-417　2008/01　Research paper (scientific journal)

A fhit-ing role in the DNA damage checkpoint response

Hideshi Ishii, Ya Wang, Kay Huebner

CELL CYCLE　Vol. 6　No. 9　p. 1044-1048　2007/05　Research paper (scientific journal)

Loss of MAL expression in precancerous lesions of the esophagus

Koshi Mimori, Kohjiro Nishida, Yoshito Nakamura, Keisuke Ieta, Yasuji Yoshikawa, Atsushi Sasaki, Hideshi Ishii, Miguel A. Alonso, Masaki Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 14　No. 5　p. 1670-1677　2007/05　Research paper (scientific journal)

Rad9 modulates the P21(WAF1) pathway by direct association with p53

Kazuhiro Ishikawa, Hideshi Ishii, Yoshiki Murakumo, Koshi Mimori, Masahiko Kobayashi, Ken-ichi Yamamoto, Masaki Mori, Hiroshi Nishino, Yusuke Furukawa, Keiichi Ichimura

BMC MOLECULAR BIOLOGY　Vol. 8　2007/05　Research paper (scientific journal)

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development

Andrea Vecchione, Gustavo Baldassarre, Hideshi Ishii, Milena S. Nicoloso, Barbara Belletti, Fabio Petrocca, Nicola Zanesi, Louise Y. Y. Fong, Sabrina Battista, Daniela Guarnieri, Raffaele Baffa, Hansjuerg Alder, John L. Farber, Peter J. Donovan, Carlo M. Croce

CANCER CELL　Vol. 11　No. 3　p. 275-289　2007/03　Research paper (scientific journal)

Fhit modulates the DNA damage checkpoint response

Hideshi Ishii, Koshi Mimori, Hiroshi Inoue, Taeko Inageta, Kazuhiro Ishikawa, Shuho Semba, Teresa Druck, Francesco Trapasso, Kenzaburo Tani, Andrea Vecchione, Carlo M. Croce, Masaki Mori, Kay Huebner

CANCER RESEARCH　Vol. 66　No. 23　p. 11287-11292　2006/12　Research paper (scientific journal)

Multiple functions of Rad9 for preserving genomic integrity

Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito, Keiichi Ichimura

CURRENT GENOMICS　Vol. 7　No. 8　p. 477-480　2006/12　Research paper (scientific journal)

DNA damage-dependent cell cycle checkpoints and genomic stability

Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito

DNA AND CELL BIOLOGY　Vol. 25　No. 7　p. 406-411　2006/07　Research paper (scientific journal)

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential

S Semba, F Trapasso, M Fabbri, KA McCorkell, S Volinia, T Druck, D Iliopoulos, Y Pekarsky, H Ishii, PN Garrison, LD Barnes, CM Croce, K Huebner

ONCOGENE　Vol. 25　No. 20　p. 2860-2872　2006/05　Research paper (scientific journal)

FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E-2-mediated cancer progression

K Mimori, H Ishii, H Nagahara, T Sudo, K Yamashita, F Inoue, GF Barnard, M Mori

CANCER RESEARCH　Vol. 66　No. 5　p. 2683-2690　2006/03　Research paper (scientific journal)

Radiation-induced response of micro RNA expression in murine embryonic stem cells

Hideshi Ishii, Toshiyuki Saito

Medicinal Chemistry　Vol. 2　No. 6　p. 555-563　2006　Research paper (scientific journal)

The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers

K Mimori, H Nagahara, T Sudo, H Ishii, K Yamashita, GF Barnard, M Mori

JOURNAL OF SURGICAL ONCOLOGY　Vol. 93　No. 1　p. 44-46　2006/01　Research paper (scientific journal)

Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib

K Sutheesophon, Y Kobayashi, MA Takatoku, K Ozawa, Y Kano, H Ishii, Y Furukawa

ACTA HAEMATOLOGICA　Vol. 115　No. 1-2　p. 78-90　2006　Research paper (scientific journal)

Differentially expressed genes in endothelial differentiation

H Ishii, K Mimori, M Mori, A Vecchione

DNA AND CELL BIOLOGY　Vol. 24　No. 7　p. 432-437　2005/07　Research paper (scientific journal)

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

H Ishii, T Inageta, K Mimori, T Saito, H Sasaki, M Isobe, M Mori, CM Croce, K Huebner, K Ozawa, Y Furukawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 102　No. 27　p. 9655-9660　2005/07　Research paper (scientific journal)

Methylation silencing of the Apaf-1 gene in acute leukemia

Y Furukawa, K Sutheesophon, T Wada, M Nishimura, Y Saito, H Ishii, Y Furukawa

MOLECULAR CANCER RESEARCH　Vol. 3　No. 6　p. 325-334　2005/06　Research paper (scientific journal)

Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228)

K Sutheesophon, N Nishimura, Y Kobayashi, Y Furukawa, M Kawano, K Itoh, Y Kano, H Ishii, Y Furukawa

JOURNAL OF CELLULAR PHYSIOLOGY　Vol. 203　No. 2　p. 387-397　2005/05　Research paper (scientific journal)

Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells

H Ishii, K Mimori, Y Yoshikawa, M Mori, Y Furukawa, A Vecchione

DNA AND CELL BIOLOGY　Vol. 24　No. 3　p. 173-179　2005/03　Research paper (scientific journal)

Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: An EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells

K Mimori, K Yamashita, M Ohta, K Yoshinaga, K Ishikawa, H Ishii, T Utsunomiya, GF Barnard, H Inoue, M Mori

CLINICAL CANCER RESEARCH　Vol. 10　No. 24　p. 8243-8249　2004/12　Research paper (scientific journal)

Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo

F Trapasso, S Yendamuri, KR Dumon, R Iuliano, R Cesari, B Feig, R Seto, L Infante, H Ishii, A Vecchione, MJ During, CM Croce, A Fusco

CARCINOGENESIS　Vol. 25　No. 11　p. 2107-2114　2004/11　Research paper (scientific journal)

Inactivation of the FHIT gene favors bladder cancer development

A Vecchione, C Sevignani, E Giarnieri, N Zanesi, H Ishii, R Cesari, LYY Fong, LG Gomella, CM Croce, R Baffa

CLINICAL CANCER RESEARCH　Vol. 10　No. 22　p. 7607-7612　2004/11　Research paper (scientific journal)

Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats

H Ishii, A Vecchione, Y Furukawa, CM Croce, K Huebner, LYY Fong

ONCOGENE　Vol. 23　No. 49　p. 8040-8048　2004/10　Research paper (scientific journal)

Collecting duct carcinoma of the kidney: An immunohistochemical study of 11 cases

Andrea Vecchione, Tommaso Prayer Galetti, Marina Gardiman, Hideshi Ishii, Enrico Giarnieri, Francesco Pagano, Leonard G. Gomella, Carlo M. Croce, Raffaele Baffa

BMC Urology　Vol. 4　2004/09/09　Research paper (scientific journal)

Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes

K Mimori, H Ueo, T Kuroki, T Shiraishi, S Creer, S Taylor, H Ishii, M Mori

ONCOLOGY REPORTS　Vol. 12　No. 1　p. 19-23　2004/07　Research paper (scientific journal)

Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX

H Ishii, K Mimori, A Vecchione, K Sutheesophon, T Fujiwara, M Mori, Y Furukawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 316　No. 4　p. 1088-1093　2004/04　Research paper (scientific journal)

Alterations of common chromosome fragile sites in hematopoietic malignancies

H Ishii, Y Furukawa

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 79　No. 3　p. 238-242　2004/04　Research paper (scientific journal)

Cancer prevention and therapy in a preclinical mouse model: Impact of FHIT viruses

H Ishii, A Vecchione, LYY Fong, N Zanesi, F Trapasso, Y Furukawa, R Baffa, K Huebner, CM Croce

CURRENT GENE THERAPY　Vol. 4　No. 1　p. 53-63　2004/03

Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies

H Ishii, A Vecchione, Y Furukawa, K Sutheesophon, SY Han, T Druck, T Kuroki, F Trapasso, M Nishimura, Y Saito, K Ozawa, CM Croce, K Huebner, Y Furukawa

MOLECULAR CANCER RESEARCH　Vol. 1　No. 13　p. 940-947　2003/11　Research paper (scientific journal)

Regression of upper gastric cancer in mice by FHIT gene delivery

H Ishii, N Zanesi, A Vecchione, F Trapasso, S Yendamuri, M Sarti, R Baffa, MJ During, K Huebner, LYY Fong, CM Croce

FASEB JOURNAL　Vol. 17　No. 10　p. 1768-+　2003/07　Research paper (scientific journal)

INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia

K Mimori, H Inoue, H Ishii, M Mori

ONCOLOGY REPORTS　Vol. 10　No. 3　p. 551-553　2003/05　Research paper (scientific journal)

Restoration of fragile Histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines

C Sevignani, GA Calin, R Cesari, M Sarti, H Ishii, S Yendamuri, A Vecchione, F Trapasso, CM Croce

CANCER RESEARCH　Vol. 63　No. 6　p. 1183-1187　2003/03　Research paper (scientific journal)

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

F Trapasso, A Krakowiak, R Cesari, J Arkles, S Yendamuri, H Ishii, A Vecchione, T Kuroki, P Bieganowski, HC Pace, K Huebner, CM Croce, C Brenner

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 100　No. 4　p. 1592-1597　2003/02　Research paper (scientific journal)

p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice

LYY Fong, H Ishii, VT Nguyen, A Vecchione, JL Farber, CM Croce, K Huebner

CANCER RESEARCH　Vol. 63　No. 1　p. 186-195　2003/01　Research paper (scientific journal)

FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells

A Vecchione, H Ishii, G Baldassarre, P Bassi, F Trapasso, H Alder, F Pagano, LG Gomella, CM Croce, R Baffa

AMERICAN JOURNAL OF PATHOLOGY　Vol. 160　No. 4　p. 1345-1352　2002/04　Research paper (scientific journal)

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines

L Roz, M Gramegna, H Ishii, CM Croce, G Sozzi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 6　p. 3615-3620　2002/03　Research paper (scientific journal)

Potential cancer therapy with the fragile histidine triad gene - Review of the preclinical studies

H Ishii, KR Dumon, A Vecchione, LYY Fong, R Baffa, K Huebner, CM Croce

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　Vol. 286　No. 19　p. 2441-2449　2001/11

Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

Y Murakumo, Y Ogura, H Ishii, S Numata, M Ichihara, CM Croce, R Fishel, M Takahashi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 38　p. 35644-35651　2001/09　Research paper (scientific journal)

FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis

H Ishii, A Vecchione, Y Murakumo, G Baldassarre, S Numata, F Trapasso, H Alder, R Baffa, CM Croce

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 98　No. 18　p. 10374-10379　2001/08　Research paper (scientific journal)

Fez1/Lzts1 alterations in gastric carcinoma

A Vecchione, H Ishii, YH Shiao, F Trapasso, M Rugge, JF Tamburrino, Y Murakumo, H Alder, CM Croce, R Baffa

CLINICAL CANCER RESEARCH　Vol. 7　No. 6　p. 1546-1552　2001/06　Research paper (scientific journal)

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer

KR Dumon, H Ishii, A Vecchione, F Trapasso, G Baldassarre, F Chakrani, T Druck, EF Rosato, NN Williams, R Baffa, MJ During, K Huebner, CM Croce

CANCER RESEARCH　Vol. 61　No. 12　p. 4827-4836　2001/06　Research paper (scientific journal)

Food and feeding of Aurelia aurita in Tokyo Bay with an analysis of stomach contents and a measurement of digestion times

H Ishii, F Tanaka

HYDROBIOLOGIA　Vol. 451　No. 1-3　p. 311-320　2001/05　Research paper (scientific journal)

FHIT gene therapy prevents tumor development in Fhit-deficient mice

KR Dumon, H Ishii, LYY Fong, N Zanesi, Fidanza, V, R Mancini, A Vecchione, R Baffa, F Trapasso, MJ During, K Huebner, CM Croce

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 98　No. 6　p. 3346-3351　2001/03　Research paper (scientific journal)

Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells

H Ishii, KR Dumon, A Vecchione, F Trapasso, K Mimori, H Alder, M Mori, G Sozzi, R Baffa, K Huebner, CM Croce

CANCER RESEARCH　Vol. 61　No. 4　p. 1578-1584　2001/02　Research paper (scientific journal)

Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer

R Baffa, R Santoro, F Bullrich, B Mandes, H Ishii, CM Croce

CLINICAL CANCER RESEARCH　Vol. 6　No. 4　p. 1372-1377　2000/04　Research paper (scientific journal)

A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2

Y Murakumo, T Roth, H Ishii, D Rasio, S Numata, CM Croce, R Fishel

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 6　p. 4391-4397　2000/02　Research paper (scientific journal)

Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs

T Ueda, H Sasaki, Y Kuwahara, M Nezu, T Shibuya, H Sakamoto, H Ishii, K Yanagihara, K Mafune, M Makuuchi, M Terada

CANCER RESEARCH　Vol. 59　No. 24　p. 6080-6086　1999/12　Research paper (scientific journal)

Serum vascular endothelial growth factor in the course of transcatheter arterial embolization of hepatocellular carcinoma

H Suzuki, M Mori, C Kawaguchi, M Adachi, S Miura, H Ishii

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 14　No. 6　p. 1087-1090　1999/06　Research paper (scientific journal)

The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors

H Ishii, R Baffa, SI Numata, Y Murakumo, S Rattan, H Inoue, M Mori, Fidanza, V, H Alder, CM Croce

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 96　No. 7　p. 3928-3933　1999/03　Research paper (scientific journal)

Monochloramine induced DNA fragmentation in gastric cell line MKN45

H Suzuki, K Seto, M Mori, M Suzuki, S Miura, H Ishii

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 275　No. 4　p. G712-G716　1998/10　Research paper (scientific journal)

Mouse Cdc21 only 0.5 kb upstream from Dna-pk(cs) in a head-to-head organization: An implication of co-evolution of ATM family members and cell cycle regulating genes

Toshiyuki Saito, Yoichi Matsuda, Hideshi Ishii, Fumiaki Watanabe, Masahiko Mori, Akiko Hayashi, Ryoko Araki, Akira Fujimori, Ryutaro Fukumura, Mitsuoki Morimyo, Koichi Tatsumi, Tada Aki Hori, Masumi Abe

Mammalian Genome　Vol. 9　No. 9　p. 769-772　1998　Research paper (scientific journal)

Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion

H Inoue, H Ishii, H Alder, E Snyder, T Druck, K Huebner, CM Croce

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 94　No. 26　p. 14584-14589　1997/12　Research paper (scientific journal)

Retinoblastoma protein expressed in human non-Hodgkin's lymphoma cells generates resistance against radiation-induced apoptosis

Hideshi Ishii, Tadahiko Igarashi, Toshiyuki Saito, Takashi Nakano, Masahiko Mori, Harumi Ohyama, Tadaaki Miyamoto, Yasushi Saito, Hakumei Oh

American Journal of Hematology　Vol. 55　No. 1　p. 46-48　1997/05　Research paper (scientific journal)

Immunohistochemical detection of K-sam protein in stomach cancer

Y Hattori, H Itoh, S Uchino, K Hosokawa, A Ochiai, Y Ino, H Ishii, H Sakamoto, N Yamaguchi, K Yanagihara, S Hirohashi, T Sugimura, M Terada

CLINICAL CANCER RESEARCH　Vol. 2　No. 8　p. 1373-1381　1996/08　Research paper (scientific journal)

A TRUNCATED K-SAM PRODUCT LACKING THE DISTAL CARBOXYL-TERMINAL PORTION PROVIDES A REDUCED LEVEL OF AUTOPHOSPHORYLATION AND GREATER RESISTANCE AGAINST INDUCTION OF DIFFERENTIATION

H ISHII, T YOSHIDA, H OH, S YOSHIDA, M TERADA

MOLECULAR AND CELLULAR BIOLOGY　Vol. 15　No. 7　p. 3664-3671　1995/07　Research paper (scientific journal)

Implication of the K-sam/FGFR2 gene in the development and progression of gastric cancer

M KATOH, H ITOH, T KISHI, H ISHII, Y HATTORI, H SAKAMOTO, T YOSHIDA, T SUGIMURA, M TERADA

1ST INTERNATIONAL GASTRIC CANCER CONGRESS, VOL 1-2　p. 763-766　1995　Research paper (international conference proceedings)

PREFERENTIAL ALTERNATIVE SPLICING IN CANCER GENERATES A K-SAM MESSENGER-RNA WITH HIGHER TRANSFORMING ACTIVITY

H ITOH, Y HATTORI, H SAKAMOTO, H ISHII, T KISHI, H SASAKI, T YOSHIDA, M KOONO, T SUGIMURA, M TERADA

CANCER RESEARCH　Vol. 54　No. 12　p. 3237-3241　1994/06　Research paper (scientific journal)

PREFERENTIAL EXPRESSION OF THE 3RD IMMUNOGLOBULIN-LIKE DOMAIN OF K-SAM PRODUCT PROVIDES KERATINOCYTE GROWTH FACTOR-DEPENDENT GROWTH IN CARCINOMA CELL-LINES

H ISHII, Y HATTORI, H ITOH, T KISHI, T YOSHIDA, H SAKAMOTO, H OH, S YOSHIDA, T SUGIMURA, M TERADA

CANCER RESEARCH　Vol. 54　No. 2　p. 518-522　1994/01　Research paper (scientific journal)