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Nakahama Taisuke
中濱 泰祐
Nakahama Taisuke
中濱 泰祐
Graduate School of Medicine Division of Medicine, Assistant Professor

Research History 3

  1. 2016 - Present
    Osaka University

  2. 2013 - 2016
    Osaka University

  3. 2012 - 2013
    Osaka University WPI Immunology Frontier Research Center

Professional Memberships 2

  1. 日本RNA学会

  2. 日本免疫学会

Research Areas 3

  1. Life sciences / Neuroscience - general /

  2. Life sciences / Molecular biology /

  3. Life sciences / Immunology /

Awards 1

  1. 日本免疫学会研究奨励賞

    日本免疫学会 2022

Papers 22

  1. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing

    Yanfang Xing*, Taisuke Nakahama*#, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara# (Co-first author*, Corresponding author#)

    Journal of Biological Chemistry p. 104840-104840 2023/05 Research paper (scientific journal)

    Publisher: Elsevier BV
  2. The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways

    Taisuke Nakahama, Yukio Kawahara

    International Immunology Vol. 35 No. 3 p. 123-133 2022/12/05 Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)
  3. An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

    Maal Inoue*, Taisuke Nakahama*, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara (Co-first author*)

    Journal of immunology (Baltimore, Md. : 1950) 2021/11/12 Research paper (scientific journal)

  4. Deciphering the Biological Significance of ADAR1-Z-RNA Interactions.

    Taisuke Nakahama, Yukio Kawahara

    International journal of molecular sciences Vol. 22 No. 21 2021/10/23 Research paper (scientific journal)

  5. Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

    Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

    Immunity Vol. 54 No. 9 p. 1976-1988.e7 2021/09 Research paper (scientific journal)

    Publisher: Elsevier BV
  6. RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

    Jung In Kim*, Taisuke Nakahama*, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara (Co-first author*)

    PLOS Genetics Vol. 17 No. 5 p. e1009516-e1009516 2021/05/13 Research paper (scientific journal)

    Publisher: Public Library of Science (PLoS)
  7. ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways.

    Tuangtong Vongpipatana*, Taisuke Nakahama*#, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara# (Co-first author*, Corresponding author#)

    Journal of immunology (Baltimore, Md. : 1950) Vol. 204 No. 8 p. 2156-2168 2020/04/15 Research paper (scientific journal)

  8. Adenosine-to-inosine RNA editing in the immune system: friend or foe?

    Taisuke Nakahama, Yukio Kawahara

    Cellular and molecular life sciences : CMLS 2020/01/29

  9. A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.

    Pedro Henrique Costa Cruz, Yuki Kato, Taisuke Nakahama, Toshiharu Shibuya, Yukio Kawahara

    RNA (New York, N.Y.) 2020/01/15

  10. ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.

    Nakahama T#, Kato Y, Kim JI, Vongpipatana T, Suzuki Y, Walkley CR, Kawahara Y# (Corresponding author#)

    EMBO Rep 2018/10 Research paper (scientific journal)

  11. Expression of aryl hydrocarbon receptor, inflammatory cytokines, and incidence of rheumatoid arthritis in Vietnamese dioxin-exposed people

    Nguyen CH, Nakahama T, Dang TT, Chu HH, Van Hoang L, Kishimoto T, Nguyen NT

    J Immunotoxicol 2017/12 Research paper (scientific journal)

  12. Immunomodulatory drugs inhibit TLR4-induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway

    David Millrine, Haruhiko Miyata, Mami Tei, Praveen Dubey, Kishan Nyati, Taisuke Nakahama, Yohannes Gemechu, Barry Ripley, Tadamitsu Kishimoto

    INTERNATIONAL IMMUNOLOGY Vol. 28 No. 6 p. 307-315 2016/06 Research paper (scientific journal)

  13. Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis

    Nam Trung Nguyen*, Taisuke Nakahama*, Chi Hung Nguyen, Trang Thu Tran, Van Son Le, Hoang Ha Chu, Tadamitsu Kishimoto (Co-first author*)

    Journal of Experimental Pharmacology Vol. 7 p. 29-35 2015/12/01

    Publisher: Dove Medical Press Ltd.
  14. The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis

    Ichino Chinen, Taisuke Nakahama, Akihiro Kimura, Nam T. Nguyen, Hiroshi Takemori, Ayako Kumagai, Hisako Kayama, Kiyoshi Takeda, Soyoung Lee, Hamza Hanieh, Barry Ripley, David Millrine, Praveen K. Dubey, Kishan K. Nyati, Yoshiaki Fujii-Kuriyama, Kamal Chowdhury, Tadamitsu Kishimoto

    INTERNATIONAL IMMUNOLOGY Vol. 27 No. 8 p. 405-415 2015/08 Research paper (scientific journal)

  15. Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research

    Nam Trung Nguyen*, Taisuke Nakahama*, Duc Hoang Le, Le Van Son, Ha Hoang Chu, Tadamitsu Kishimoto (Co-first author*)

    FRONTIERS IN IMMUNOLOGY Vol. 5 2014/10 Research paper (scientific journal)

  16. Aryl hydrocarbon receptor and experimental autoimmune arthritis

    Nam Trung Nguyen*, Taisuke Nakahama*, Tadamitsu Kishimoto (Co-first author*)

    SEMINARS IN IMMUNOPATHOLOGY Vol. 35 No. 6 p. 637-644 2013/11 Research paper (scientific journal)

  17. Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation

    Taisuke Nakahama, Hamza Hanieh, Nam Trung Nguyen, Ichino Chinen, Barry Ripley, David Millrine, Soyoung Lee, Kishan Kumar Nyati, Praveen Kumar Dubey, Kamal Chowdhury, Yukio Kawahara, Tadamitsu Kishimoto

    Proceedings of the National Academy of Sciences of the United States of America Vol. 110 No. 29 p. 11964-11969 2013/07/16 Research paper (scientific journal)

  18. The roles of aryl hydrocarbon receptor in immune responses

    Nam Trung Nguyen*, Hamza Hanieh*, Taisuke Nakahama*, Tadamitsu Kishimoto (Co-first author*)

    INTERNATIONAL IMMUNOLOGY Vol. 25 No. 6 p. 335-343 2013/06 Research paper (scientific journal)

  19. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages

    Kazuya Masuda, Akihiro Kimura, Hamza Hanieh, Nam Trung Nguyen, Taisuke Nakahama, Ichino Chinen, Yuichi Otoyo, Tomotaka Murotani, Atsushi Yamatodani, Tadamitsu Kishimoto

    INTERNATIONAL IMMUNOLOGY Vol. 23 No. 10 p. 637-645 2011/10 Research paper (scientific journal)

  20. Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

    Taisuke Nakahama, Akihiro Kimura, Nam Trung Nguyen, Ichino Chinen, Hamza Hanieh, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 108 No. 34 p. 14222-14227 2011/08 Research paper (scientific journal)

  21. Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

    Nam Trung Nguyen, Akihiro Kimura, Taisuke Nakahama, Ichino Chinen, Kazuya Masuda, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 107 No. 46 p. 19961-19966 2010/11 Research paper (scientific journal)

  22. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

    Akihiro Kimura, Tetsuji Naka, Taisuke Nakahama, Ichino Chinen, Kazuya Masuda, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto

    JOURNAL OF EXPERIMENTAL MEDICINE Vol. 206 No. 9 p. 2027-2035 2009/08 Research paper (scientific journal)

Misc. 7

  1. The roles of RNA editing in viral infection.

    中濱泰祐, 河原行郎

    月刊臨床免疫・アレルギー科 Vol. 80 No. 4 2023

  2. Regulation of dsRNA-sensing systems by the RNA-editing enzyme ADAR1.

    中濱泰祐

    月刊臨床免疫・アレルギー科 Vol. 80 No. 5 2023

  3. Reduced RNA editing activity of ADAR1 p150 induces Aicardi-Goutieres syndrome-like symptoms in mice.

    中濱泰祐, 河原行郎

    月刊臨床免疫・アレルギー科 Vol. 77 No. 6 p. 737-743 2022/06 Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  4. Innate immune responses to left-handed Z-RNAs

    中濱泰祐, 河原行郎

    実験医学 Vol. 40 No. 4 p. 544-549 2022/03 Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  5. Type I interferonopathies caused by dysregulation of RNA metabolism

    中濱泰祐, 河原行郎

    実験医学 Vol. 40 No. 15 2022

  6. 自己免疫疾患とRNA編集

    三宅浩太郎, 中濱泰祐, 河原行郎

    実験医学(増刊) Vol. 33 No. 20 p. 3339-3344 2015

  7. 関節リウマチにおけるAHRの役割

    中濱泰祐

    臨床免疫・アレルギー科 Vol. 60 No. 4 p. 373-378 2013/10 Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

Presentations 2

  1. RNA編集酵素ADAR1による自然免疫制御の新たな展開

    中濱泰祐

    第1回 Kansai RNA Club 2023/08/18

  2. Regulatory mechanisms underlying ADAR1 p150-mediated RNA editing

    Taisuke Nakahama

    ABZ meeting 2022 (A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA) 2022/09/07