Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection

Kendall Free, Hideyuki Nakanishi, Keiji Itaka

Pharmaceutics　Vol. 15　No. 1　2023/01/07　Research paper (scientific journal)

Unbiased comparison and modularization identify time-related transcriptomic reprogramming in exercised rat cartilage: Integrated data mining and experimental validation.

Jiarui Cui, Yo Shibata, Keiji Itaka, Jun Zhou, Jiaming Zhang

Frontiers in physiology　Vol. 13　p. 974266-974266　2022/09/15　Research paper (scientific journal)

Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.

Yasumasa Hashimoto, Hiroshi Kuniishi, Kazuhisa Sakai, Yuta Fukushima, Xuan Du, Kunihiko Yamashiro, Kei Hori, Michihiro Imamura, Mikio Hoshino, Mitsuhiko Yamada, Toshiyuki Araki, Hiroyuki Sakagami, Shin'ichi Takeda, Keiji Itaka, Noritaka Ichinohe, Francesco Muntoni, Masayuki Sekiguchi, Yoshitsugu Aoki

Progress in neurobiology　Vol. 216　p. 102288-102288　2022/09　Research paper (scientific journal)

Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist.

Jia Deng, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Erica Yada, Yuki Terai, Kenji Fueki, Keiji Itaka

Pharmaceutics　Vol. 14　No. 9　2022/08/26　Research paper (scientific journal)

Influence of Nanobubble Size Distribution on Ultrasound-Mediated Plasmid DNA and Messenger RNA Gene Delivery.

Hiroshi Kida, Loreto B Feril, Yutaka Irie, Hitomi Endo, Keiji Itaka, Katsuro Tachibana

Frontiers in pharmacology　Vol. 13　p. 855495-855495　2022/06/21　Research paper (scientific journal)

Synthetic mRNA for ex vivo therapeutic applications.

Hideyuki Nakanishi, Keiji Itaka

Drug metabolism and pharmacokinetics　Vol. 44　p. 100447-100447　2022/06　Research paper (scientific journal)

脂質合成転写因子SREBP-1が多価不飽和脂肪酸を感受する機構の解明

升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 呼延 宜人, Mehrazad Saber Zahra, 沢田 義一, 村山 友樹, 會田 雄一, 西 真貴子[辰巳], 泉田 欣彦, 位高 啓史, 片岡 一則, 島野 仁, 門脇 孝, 山内 敏正, 筑波大学医学医療系ニュートリゲノミクスリサーチグループ

糖尿病　Vol. 65　No. Suppl.1　p. S-308　2022/04

Versatile Design of Intracellular Protein-Responsive Translational Regulation System for Synthetic mRNA.

Hideyuki Nakanishi, Hirohide Saito, Keiji Itaka

ACS synthetic biology　Vol. 11　No. 3　p. 1077-1085　2022/03/18　Research paper (scientific journal)

Raman spectroscopic insight into osteoarthritic cartilage regeneration by mRNA therapeutics encoding cartilage-anabolic transcription factor Runx1.

Giuseppe Pezzotti, Wenliang Zhu, Yuki Terai, Elia Marin, Francesco Boschetto, Komei Kawamoto, Keiji Itaka

Materials today. Bio　Vol. 13　p. 100210-100210　2022/01　Research paper (scientific journal)

Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice.

Natsuko Oyama, Maho Kawaguchi, Keiji Itaka, Shigeru Kawakami

Pharmaceutics　Vol. 13　No. 11　2021/10/29　Research paper (scientific journal)

多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明

升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 呼延 宜人, Zahra Mehrazad Saber, 沢田 義一, 村山 友樹, 會田 雄一, 西 真貴子[辰巳], 泉田 欣彦, 位高 啓史, 片岡 一則, 島野 仁, 門脇 孝, 山内 敏正

糖尿病　Vol. 64　No. Suppl.1　p. P-1　2021/05

Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle

Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka

Biomaterials　Vol. 270　p. 120681-120681　2021/03　Research paper (scientific journal)

Regulation of Chondrocyte Differentiation by Changing Intercellular Distances Using Type II Collagen Microfibers.

Jinyu Li, Naoko Sasaki, Keiji Itaka, Margo Terpstra, Riccardo Levato, Michiya Matsusaki

ACS biomaterials science & engineering　Vol. 6　No. 10　p. 5711-5719　2020/10/12　Research paper (scientific journal)

多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明

升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 呼延 宜人, 李 恩旭, Saber Zahra Mehrazad, 沢田 義一, 村山 友樹, 會田 雄一, 西 真貴子[辰巳], 泉田 欣彦, 飯塚 陽子, 位高 啓史, 片岡 一則, 島野 仁, 門脇 孝

糖尿病　Vol. 63　No. Suppl.1　p. S-336　2020/08

mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy

Satoshi Uchida, Kayoko Yanagihara, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka

Micromachines　Vol. 11　No. 4　2020/04/18　Research paper (scientific journal)

Enhanced Antibacterial Property of Facet-Engineered TiO2 Nanosheet in Presence and Absence of Ultraviolet Irradiation.

Kenichiro Hayashi, Kosuke Nozaki, Zhenquan Tan, Kazuhisa Fujita, Reina Nemoto, Kimihiro Yamashita, Hiroyuki Miura, Keiji Itaka, Satoshi Ohara

Materials (Basel, Switzerland)　Vol. 13　No. 1　2019/12/22　Research paper (scientific journal)

骨格筋を標的とするmRNA医薬の開発と末梢神経障害治療への応用

蛯原 郁弥, 長田 和也, 福島 雄大, 松本 征仁, 位高 啓史

日本バイオマテリアル学会大会予稿集　Vol. 41回　p. 512-512　2019/11

mRNA医薬の骨格筋への投与による末梢神経障害の早期機能回復

蛯原 郁弥, 長田 和也, 福島 雄大, 松本 征仁, 位高 啓史

日本DDS学会学術集会プログラム予稿集　Vol. 35回　p. 182-182　2019/06

mRNA医薬の脳神経保護薬への展開 BDNF mRNAのナノミセルによる脳室内投与

福島 雄大, 内田 智士, 片岡 一則, 位高 啓史

日本DDS学会学術集会プログラム予稿集　Vol. 35回　p. 154-154　2019/06

Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA.

Crowley ST, Fukushima Y, Uchida S, Kataoka K, Itaka K

Molecular therapy. Nucleic acids　Vol. 17　p. 465-476　2019/06　Research paper (scientific journal)

多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明

升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 呼延 宜人, 李 恩旭, Mehrazad Saber Zahra, 沢田 義一, 村山 友樹, 會田 雄一, 西 真貴子[辰巳], 泉田 欣彦, 飯塚 陽子, 位高 啓史, 片岡 一則, 島野 仁, 門脇 孝

糖尿病　Vol. 62　No. Suppl.1　p. S-249　2019/04

Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor.

Lin CY, Crowley ST, Uchida S, Komaki Y, Kataoka K, Itaka K

Molecular therapy. Nucleic acids　Vol. 16　p. 162-171　2019/02　Research paper (scientific journal)

コレステロール修飾相補鎖RNAを用いたmRNA搭載高分子ミセル安定化

内田 智士, 吉永 直人, 長田 健介, 位高 啓史, Cabral Horacio, 片岡 一則

日本バイオマテリアル学会大会予稿集　Vol. 40回　p. 177-177　2018/11

Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection.

Matsui A, Uchida S, Hayashi A, Kataoka K, Itaka K

Journal of controlled release : official journal of the Controlled Release Society　Vol. 285　p. 1-11　2018/09　Research paper (scientific journal)

Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids.

Kayoko Yanagihara, Satoshi Uchida, Shinsuke Ohba, Kazunori Kataoka, Keiji Itaka

Molecular therapy. Methods & clinical development　Vol. 9　p. 358-366　2018/06/15　Research paper (scientific journal)

少数のコレステロール修飾RNAオリゴマーにより誘起されるmRNA内包高分子ミセルの構造安定化およびマウス肺局所投与への応用

吉永 直人, 内田 智士, 長田 健介, 位高 啓史, Horacio Cabral, 片岡 一則

日本DDS学会学術集会プログラム予稿集　Vol. 34回　p. 178-178　2018/05

Incorporation of Immunostimulatory Property to Messenger RNA Molecule by Hybridizing RNA to Poly a Sequence for Effective Vaccination

Uchida Satoshi, Itaka Keiji, Kataoka Kazunori

Molecular Therapy　Vol. 26　No. 5　p. 243-244　2018/05　Research paper (international conference proceedings)

Combined CatWalk Index: An improved method to measure mouse motor function using the automated gait analysis system

Samuel T. Crowley, Kazunori Kataoka, Keiji Itaka

BMC Research Notes　Vol. 11　No. 1　p. 263-263　2018/04/27　Research paper (scientific journal)

Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination

Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka

BIOMATERIALS　Vol. 150　p. 162-170　2018/01　Research paper (scientific journal)

mRNAデリバリーによる虚血性神経細胞死治療 Enhancement of neuroprotective effect of astrocytes

福島 雄大, 今井 英明, 内田 智士, 中冨 浩文, 片岡 一則, 位高 啓史, 斉藤 延人

脳循環代謝　Vol. 29　No. 1　p. 221-221　2017/11

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain.

Anraku Y, Kuwahara H, Fukusato Y, Mizoguchi A, Ishii T, Nitta K, Matsumoto Y, Toh K, Miyata K, Uchida S, Nishina K, Osada K, Itaka K, Nishiyama N, Mizusawa H, Yamasoba T, Yokota T, Kataoka K

Nature communications　Vol. 8　No. 1　2017/10　Research paper (scientific journal)

虚血性脳神経疾患に対するmRNA投与による神経保護治療

福島 雄大, 内田 智士, 今井 英明, 中冨 浩文, 片岡 一則, 斉藤 延人, 位高 啓史

日本DDS学会学術集会プログラム予稿集　Vol. 33回　p. 162-162　2017/06

Nonviral Delivery of BDNF mRNA Polyplex Improves Recovery After Spinal Cord Injury in Mice

Crowley T. Samuel, Uchida Satoshi, Kataoka Kazunori, Itaka Keiji

Molecular Therapy　Vol. 25　No. 5　2017/05　Research paper (international conference proceedings)

Improved Brain Expression of Anti-Amyloid beta scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer

Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka

CURRENT ALZHEIMER RESEARCH　Vol. 14　No. 3　p. 295-302　2017　Research paper (scientific journal)

Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids

Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka

BIOMATERIALS　Vol. 109　p. 1-11　2016/12　Research paper (scientific journal)

Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer

Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka

Current Alzheimer Research　Vol. 13　No. 999　p. 1-1　2016/11/08　Research paper (scientific journal)

mRNAデリバリーによる海馬遅発性神経細胞死の治療と経時変化に着目した病態解析

福島 雄大, 内田 智士, 小野 秀明, 今井 英明, 位高 啓史, 中冨 浩文, 片岡 一則, 斉藤 延人

脳循環代謝　Vol. 28　No. 1　p. 190-190　2016/11

mRNA関節内投与による軟骨形成性転写因子導入と変形性関節症治療

位高 啓史, Aini Hailati, 齋藤 琢, 片岡 一則, 鄭 雄一, 大庭 伸介

日本整形外科学会雑誌　Vol. 90　No. 8　p. S1764-S1764　2016/08

Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles

Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka

JOURNAL OF CONTROLLED RELEASE　Vol. 235　p. 268-275　2016/08　Research paper (scientific journal)

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Yuki Murayama, Yoshikazu Sawada, Xiaoying Piao, Naoki Toya, Yukari Oya, Akito Shikama, Ayako Takarada, Yukari Masuda, Makiko Nishi, Midori Kubota, Yoshihiko Izumida, Takashi Yamamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Osamu Urayama, Yasushi Kawakami, Yoko Iizuka, Takanari Gotoda, Keiji Itaka, Kazunori Kataoka, Ryozo Nagai, Takashi Kadowaki, Nobuhiro Yamada, Yuan Lu, Mukesh K. Jain, Hitoshi Shimano

CELL REPORTS　Vol. 16　No. 9　p. 2373-2386　2016/08　Research paper (scientific journal)

ナノミセルを用いた治療用転写因子のmRNA送達はマウスモデルにおいて変形性関節症の進行を抑制する

海拉提 艾尼, 位高 啓史, 斉藤 琢, 鄭 雄一, 大庭 伸介

日本骨代謝学会学術集会プログラム抄録集　Vol. 34回　p. 209-209　2016/07

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Machitani Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka, Kazunori Kataoka

BIOMATERIALS　Vol. 82　p. 221-228　2016/03　Research paper (scientific journal)

Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure

Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 138　No. 5　p. 1478-1481　2016/02　Research paper (scientific journal)

Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment

Hailati Aini, Keiji Itaka, Ayano Fujisawa, Hirokuni Uchida, Satoshi Uchida, Shigeto Fukushima, Kazunori Kataoka, Taku Saito, Ung-il Chung, Shinsuke Ohba

SCIENTIFIC REPORTS　Vol. 6　p. 18743-18743　2016/01　Research paper (scientific journal)

Development of mRNA-based therapeutics.

Itaka K

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 148　No. 4　p. 190-196　2016　Research paper (scientific journal)

Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases

Akitsugu Matsui, Satoshi Uchida, Takehiko Ishii, Keiji Itaka, Kazunori Kataoka

SCIENTIFIC REPORTS　Vol. 5　p. 15810-15810　2015/10　Research paper (scientific journal)

多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明

升田 紫, 矢作 直也, 武内 謙憲, 和田 亘弘, 李 恩旭, 沢田 義一, 朴 賢英, 會田 雄一, 戸谷 直樹, 志鎌 明人, 西 真貴子, 久保田 みどり, 泉田 欣彦, 飯塚 陽子, 位高 啓史, 片岡 一則, 山田 信博, 島野 仁, 門脇 孝

肥満研究　Vol. 21　No. Suppl.　p. 208-208　2015/09

Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression

Yanmin Li, Kensuke Osada, Qixian Chen, Theofilus A. Tockary, Anjaneyulu Dirisala, Kaori M. Takeda, Satoshi Uchida, Kazuya Nagata, Keiji Itaka, Kazunori Kataoka

BIOMACROMOLECULES　Vol. 16　No. 9　p. 2664-2671　2015/09　Research paper (scientific journal)

Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying

Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamto

Pharmaceutics　Vol. 7　No. 3　p. 233-254　2015/08/26　Research paper (scientific journal)

Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity

Satoshi Uchida, Kazunori Kataoka, Keiji Itaka

Pharmaceutics　Vol. 7　No. 3　p. 137-151　2015/07/23　Research paper (scientific journal)

Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation

Keiji Itaka, Satoshi Uchida, Akitsugu Matsui, Kayoko Yanagihara, Masaru Ikegami, Taisuke Endo, Takehiko Ishii, Kazunori Kataoka

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS　No. 101　2015/07　Research paper (scientific journal)

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

Miyuki Baba, Keiji Itaka, Kenji Kondo, Tatsuya Yamasoba, Kazunori Kataoka

JOURNAL OF CONTROLLED RELEASE　Vol. 201　p. 41-48　2015/03　Research paper (scientific journal)

Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury

Kentaro Hayakawa, Satoshi Uchida, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka

JOURNAL OF CONTROLLED RELEASE　Vol. 197　p. 1-9　2015/01　Research paper (scientific journal)

A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle

Qixian Chen, Kensuke Osada, Matthew Pennisi, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Yanmin Li, Kaori M. Takeda, Satoshi Oniyanagi, Keiji Itaka, Kazunori Kataoka

SOFT MATTER　Vol. 11　No. 14　p. 2718-2722　2015　Research paper (scientific journal)

Modulated Protonation of Side Chain Aminoethylene Repeats in N-Substituted Polyaspartamides Promotes mRNA Transfection

Hirokuni Uchida, Keiji Itaka, Takahiro Nomoto, Takehiko Ishii, Tomoya Suma, Masaru Ikegami, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 136　No. 35　p. 12396-12405　2014/09　Research paper (scientific journal)

間葉系幹細胞スフェロイド移植の骨再生治療への応用 ナノミセルを用いた遺伝子導入による細胞機能活性化

柳原 歌代子, 内田 智士, 池上 賢, 遠藤 泰輔, 前田 祐二郎, 大庭 伸介, 鄭 雄一, 石井 武彦, 片岡 一則, 位高 啓史

日本DDS学会学術集会プログラム予稿集　Vol. 30回　p. 205-205　2014/07

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors

Anjaneyulu Dirisala, Kensuke Osada, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka

BIOMATERIALS　Vol. 35　No. 20　p. 5359-5368　2014/07　Research paper (scientific journal)

Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury

Kazuya Nagata, Keiji Itaka, Miyuki Baba, Satoshi Uchida, Takehiko Ishii, Kazunori Kataoka

JOURNAL OF CONTROLLED RELEASE　Vol. 183　p. 27-34　2014/06　Research paper (scientific journal)

An injectable spheroid system with genetic modification for cell transplantation therapy

Satoshi Uchida, Keiji Itaka, Takahiro Nomoto, Taisuke Endo, Yu Matsumoto, Takehiko Ishii, Kazunori Kataoka

BIOMATERIALS　Vol. 35　No. 8　p. 2499-2506　2014/03　Research paper (scientific journal)

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

Zhishen Ge, Qixian Chen, Kensuke Osada, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka

BIOMATERIALS　Vol. 35　No. 10　p. 3416-3426　2014/03　Research paper (scientific journal)

Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization (vol 4, pg 2316, 2013)

Yoshihiko Izumida, Naoya Yahagi, Yoshinori Takeuchi, Makiko Nishi, Akito Shikama, Ayako Takarada, Yukari Masuda, Midori Kubota, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Iizuka, Keiji Itaka, Kazunori Kataoka, Seiji Shioda, Akira Niijima, Tetsuya Yamada, Hideki Katagiri, Ryozo Nagai, Nobuhiro Yamada, Takashi Kadowaki, Hitoshi Shimano

NATURE COMMUNICATIONS　Vol. 4　2013/12

Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers

Tockary Theofilus A, Osada Kensuke, Chen Qixian, Machitani Kaori, Dirisala Anjaneyulu, Uchida Satoshi, Nomoto Takahiro, Toh Kazuko, Matsumoto Yu, Itaka Keiji, Nitta Koji, Nagayama Kuniaki, Kataoka Kazunori

MACROMOLECULES　Vol. 46　No. 16　p. 6585-6592　2013/08/27　Research paper (scientific journal)

Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization

Yoshihiko Izumida, Naoya Yahagi, Yoshinori Takeuchi, Makiko Nishi, Akito Shikama, Ayako Takarada, Yukari Masuda, Midori Kubota, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Iizuka, Keiji Itaka, Kazunori Kataoka, Seiji Shioda, Akira Niijima, Tetsuya Yamada, Hideki Katagiri, Ryozo Nagai, Nobuhiro Yamada, Takashi Kadowaki, Hitoshi Shimano

NATURE COMMUNICATIONS　Vol. 4　p. 2316-2316　2013/08　Research paper (scientific journal)

Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys

Masahiro Ohgidani, Koichi Furugaki, Kentaro Shinkai, Yumi Kunisawa, Keiji Itaka, Kazunori Kataoka, Kenji Nakano

JOURNAL OF CONTROLLED RELEASE　Vol. 167　No. 3　p. 238-247　2013/05　Research paper (scientific journal)

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

Satoshi Uchida, Keiji Itaka, Hirokuni Uchida, Kentaro Hayakawa, Toru Ogata, Takehiko Ishii, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka

PLOS ONE　Vol. 8　No. 2　2013/02　Research paper (scientific journal)

Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation

Taisuke Endo, Keiji Itaka, Momoko Shioyama, Satoshi Uchida, Kazunori Kataoka

DRUG DELIVERY AND TRANSLATIONAL RESEARCH　Vol. 2　No. 5　p. 398-405　2012/10　Research paper (scientific journal)

PEGylated Polyplex With Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses

Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Takehiko Ishii, Masa-Aki Shibata, Mariko Harada-Shiba, Kazunori Kataoka

MOLECULAR THERAPY　Vol. 20　No. 6　p. 1196-1203　2012/06　Research paper (scientific journal)

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors

Qixian Chen, Kensuke Osada, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka

BIOMATERIALS　Vol. 33　No. 18　p. 4722-4730　2012/06　Research paper (scientific journal)

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination

Michiaki Kumagai, Shinya Shimoda, Rie Wakabayashi, Yumi Kunisawa, Takehiko Ishii, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka, Kenji Nakano

JOURNAL OF CONTROLLED RELEASE　Vol. 160　No. 3　p. 542-551　2012/06　Research paper (scientific journal)

Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain

Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka

BIOMATERIALS　Vol. 33　No. 9　p. 2770-2779　2012/03　Research paper (scientific journal)

Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles

Kensuke Osada, Tomonori Shiotani, Theofilus A. Tockary, Daigo Kobayashi, Hiroki Oshima, Sorato Ikeda, Ronald J. Christie, Keiji Itaka, Kazunori Kataoka

BIOMATERIALS　Vol. 33　No. 1　p. 325-332　2012/01　Research paper (scientific journal)

Progress and Prospects of Polyplex Nanomicelles for Plasmid DNA Delivery

Keiji Itaka, Kazunori Kataoka

CURRENT GENE THERAPY　Vol. 11　No. 6　p. 457-465　2011/12　Research paper (scientific journal)

Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N '-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity

Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka

JOURNAL OF CONTROLLED RELEASE　Vol. 155　No. 2　p. 296-302　2011/10　Research paper (scientific journal)

Odd-Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles

Hirokuni Uchida, Kanjiro Miyata, Makoto Oba, Takehiko Ishii, Tomoya Suma, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 133　No. 39　p. 15524-15532　2011/10　Research paper (scientific journal)

Enhanced transfection with silica-coated polyplexes loading plasmid DNA

Kanjiro Miyata, Noha Gouda, Hiroyasu Takemoto, Makoto Oba, Yan Lee, Hiroyuki Koyama, Yuichi Yamasaki, Keiji Itake, Nobuhiro Nishiyama, Kazunori Kataoka

BIOMATERIALS　Vol. 31　No. 17　p. 4764-4770　2010/06　Research paper (scientific journal)

Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity

Keiji Itaka, Takehiko Ishii, Yoko Hasegawa, Kazunori Kataoka

BIOMATERIALS　Vol. 31　No. 13　p. 3707-3714　2010/05　Research paper (scientific journal)

Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle

Keiji Itaka, Kensuke Osada, Katsue Morii, Pilhan Kim, Seok-Hyun Yun, Kazunori Kataoka

JOURNAL OF CONTROLLED RELEASE　Vol. 143　No. 1　p. 112-119　2010/04　Research paper (scientific journal)

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit

Yoshinori Takeuchi, Naoya Yahagi, Yoshihiko Izumida, Makiko Nishi, Midori Kubota, Yuji Teraoka, Takashi Yamamoto, Takashi Matsuzaka, Yoshimi Nakagawa, Motohiro Sekiya, Yoko Iizuka, Ken Ohashi, Jun-ichi Osuga, Takanari Gotoda, Shun Ishibashi, Keiji Itaka, Kazunori Kataoka, Ryozo Nagai, Nobuhiro Yamada, Takashi Kadowaki, Hitoshi Shimano

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 15　p. 11681-11691　2010/04　Research paper (scientific journal)

Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1

Makoto Oba, Yelena Vachutinsky, Kanjiro Miyata, Mitsunobu R. Kano, Sorato Ikeda, Nobuhiro Nishiyama, Keiji Itaka, Kohei Miyazono, Hiroyuki Koyama, Kazunori Kataoka

MOLECULAR PHARMACEUTICS　Vol. 7　No. 2　p. 501-509　2010/03　Research paper (scientific journal)

Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles

Yan Lee, Takehiko Ishii, Hyun Jin Kim, Nobuhiro Nishiyama, Yoshiyuki Hayakawa, Keiji Itaka, Kazunori Kataoka

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 49　No. 14　p. 2552-2555　2010　Research paper (scientific journal)

A Nanoparticle System Specifically Designed to Deliver Short Interfering RNA Inhibits Tumor Growth In vivo

Nobuhiro Yagi, Ichiro Manabe, Tsuneaki Tottori, Atsushi Ishihara, Fusa Ogata, Jong Heon Kim, Satoshi Nishimura, Katsuhito Fujiu, Yumiko Oishi, Keiji Itaka, Yasuki Kato, Masahiro Yamauchi, Ryozo Nagai

CANCER RESEARCH　Vol. 69　No. 16　p. 6531-6538　2009/08　Research paper (scientific journal)

Intratracheal Gene Transfer of Adrenomedullin Using Polyplex Nanomicelles Attenuates Monocrotaline-induced Pulmonary Hypertension in Rats

Mariko Harada-Shiba, Itaru Takamisawa, Kanjiro Miyata, Takehiko Ishii, Nobuhiro Nishiyama, Keiji Itaka, Kenji Kangawa, Fumiki Yoshihara, Yujiro Asada, Kinta Hatakeyama, Noriya Nagaya, Kazunori Kataoka

MOLECULAR THERAPY　Vol. 17　No. 7　p. 1180-1186　2009/07　Research paper (scientific journal)

Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers

Yu Matsumoto, Keiji Itaka, Tatsuya Yamasoba, Kazunori Kataoka

JOURNAL OF GENE MEDICINE　Vol. 11　No. 7　p. 615-623　2009/07　Research paper (scientific journal)

3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells

Wenjie Wang, Keiji Itaka, Shinsuke Ohba, Nobuhiro Nishiyama, Ung-il Chung, Yuichi Yamasaki, Kazunori Kataoka

BIOMATERIALS　Vol. 30　No. 14　p. 2705-2715　2009/05　Research paper (scientific journal)

Recent development of nonviral gene delivery systems with virus-like structures and mechanisms

Keiji Itaka, Kazunori Kataoka

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS　Vol. 71　No. 3　p. 475-483　2009/03　Research paper (scientific journal)

Angiogenesis through Silencing Prolyl Hydroxylase Domain-2 Using Biocompatible Polyplex Nanocarrier

Wu Shourong, Nishiyama Nobuhiro, Itaka Keiji, Kano Mitsunobu R, Morishita Yasuyuki, Miyazono Kohei, Chung Ung-Il, Kataoka Kazunori

Molecular Therapy　Vol. 17　p. S390-S390　2009

Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Cross-Links Directing to the Enhanced Transfection via Controlled Intracellular Trafficking

Makoto Oba, Kazuhiro Aoyagi, Kanjiro Miyata, Yu Matsumoto, Keiji Itaka, Nobuhiro Nishiyama, Yuichi Yarnasaki, Hiroyuki Koyama, Kazunori Kataoka

MOLECULAR PHARMACEUTICS　Vol. 5　No. 6　p. 1080-1092　2008/11　Research paper (scientific journal)

Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene

Shourong Wu, Nobuhiro Nishiyama, Mitsunobu R. Kano, Yasuyuki Morishita, Kohei Miyazono, Keiji Itaka, Ung-il Chung, Kazunori Kataoka

MOLECULAR THERAPY　Vol. 16　No. 7　p. 1227-1234　2008/07　Research paper (scientific journal)

PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors

Seiji Takae, Kanjiro Miyata, Makoto Oba, Takehiko Ishii, Nobuhiro Nishiyama, Keiji Itaka, Yuichi Yamasaki, Hiroyuki Koyama, Kazunori Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 130　No. 18　p. 6001-6009　2008/05　Research paper (scientific journal)

[Polyplex nanomicelles for drug delivery system].

Itaka K

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 49　No. 5　p. 287-293　2008/05　Research paper (scientific journal)

Medical system innovation through multidisciplinary integration

tits　Vol. 13　No. 9　p. 74-77　2008

Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity

Kayo Masago, Keiji Itaka, Nobuhiro Nishiyama, Ung-il Chung, Kazunori Kataoka

BIOMATERIALS　Vol. 28　No. 34　p. 5169-5175　2007/12　Research paper (scientific journal)

Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes

Motoi Oishi, Yukio Nagasaki, Nobuhiro Nishiyama, Keiji Itaka, Motoki Takagi, Akira Shimamoto, Yasuhiro Furuichi, Kazunori Kataoka

CHEMMEDCHEM　Vol. 2　No. 9　p. 1290-1297　2007/09　Research paper (scientific journal)

Bone regeneration by regulated in vivo gene transfer using Biocompatible polyplex nanomicelles

Keiji Itaka, Shinsuke Ohba, Kanjiro Miyata, Hiroshi Kawaguchi, Kozo Nakamura, Tsuyoshi Takato, Ung-Il Chung, Kazunori Kataoka

MOLECULAR THERAPY　Vol. 15　No. 9　p. 1655-1662　2007/09　Research paper (scientific journal)

pH-responsive PEGylated nanogels as targetable and low invasive endosomolytic agents to induce the enhanced transfection efficiency of nonviral gene vectors

Oishi Motoi, Hayashi Hisato, Itaka Keiji, Kataoka Kazunori, Nagasaki Yukio

Colloid and Polymer Science　Vol. 285　No. 9　p. 1055-1060　2007/06　Research paper (scientific journal)

Identification and characterization of the human SOX6 promoter

Toshiyuki Ikeda, Taku Saito, Masahiro Ushita, Fumiko Yano, Akinorl Kan, Keiji Itaka, Toru Moro, Kozo Nakamura, Hiroshi Kawaguchi, Ung-il Chung

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 357　No. 2　p. 383-390　2007/06　Research paper (scientific journal)

A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner

Shinsuke Ohba, Keiji Nakajima, Yusuke Komiyama, Fumitaka Kugimiya, Kazuyo Igawa, Keiji Itaka, Toru Moro, Kozo Nakamura, Hiroshi Kawaguchi, Tsuyoshi Takato, Ung-il Chung

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 357　No. 4　p. 854-860　2007/06　Research paper (scientific journal)

Scaffolds for skeletal regeneration

Ung-Il Chung, Keiji Itaka, Nobuhiro Nishiyama, Tsuyoshi Takato, Hiroshi Kawaguchi, Kozo Nakamura, Kazunori Kataoka

Nanobiotechnology　Vol. 3　No. 2　p. 104-106　2007/05　Research paper (scientific journal)

Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly (ethylene glycol)-siRNA Conjugate Formulated in PEGylated Polyplexes

Oishi, Motoi, Nagasaki, Yukio, Nishiyama, Nobuhiro, Itaka, Keiji, Takagi, Motoki, Shimamoto, Akira, Furuichi, Yasuhiro, Kataoka, Kazunori

ChemMedChem　Vol. 2　No. 9　p. 1290-1297　2007/01　Research paper (scientific journal)

A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells

Naoki Kanayama, Shigeto Fukushima, Nobuhiro Nishiyama, Keiji Itaka, Woo-Dong Jang, Kanjiro Miyata, Yuichi Yamasaki, Ung-il Chung, Kazunori Kataoka

CHEMMEDCHEM　Vol. 1　No. 4　p. 439-444　2006/04　Research paper (scientific journal)

The state of the art of nanobioscience in Japan

S Ueno, J Ando, H Fujita, T Sugawara, Y Jimbo, K Itaka, K Kataoka, T Ushida

IEEE TRANSACTIONS ON NANOBIOSCIENCE　Vol. 5　No. 1　p. 54-65　2006/03　Research paper (scientific journal)

[Supramolecular nanocarrier for gene and siRNA delivery].

Itaka K, Chung UI, Kataoka K

Nihon rinsho. Japanese journal of clinical medicine　Vol. 64　No. 2　p. 253-257　2006/02　Research paper (scientific journal)

Supamolecular assemblies for delivery of nucleic acid medicines

Motoi Oishi, Nobuhiro Nishiyama, Keiji Itaka, Atsushi Ishii, Motoki Takagi, Akira Shimamoto, Yasuhiro Furuichi, Kazunori Kataoka, Yukio Nagasaki

Polymer Preprints, Japan　Vol. 55　No. 2　p. 5268-5269　2006　Research paper (international conference proceedings)

Enhanced tumor growth inhibition against multicelluler tumor spheroids induced by smart PIC micelles composed of PEG-siRNA conjugate and polycation

Motoi Oishi, Nobuhiro Nishiyama, Keiji Itaka, Motoki Takagi, Akira Shimamoto, Yasuhiro Furuichi, Kazunori Kataoka, Yukio Nagasaki

Polymer Preprints, Japan　Vol. 55　No. 1　2006　Research paper (international conference proceedings)

Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer

N Nishiyama, A Iriyama, WD Jang, K Miyata, K Itaka, Y Inoue, H Takahashi, Y Yanagi, Y Tamaki, H Koyama, K Kataoka

NATURE MATERIALS　Vol. 4　No. 12　p. 934-941　2005/12　Research paper (scientific journal)

Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile ss-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells

M Oishi, Y Nagasaki, K Itaka, N Nishiyama, K Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 127　No. 6　p. 1624-1625　2005/02　Research paper (scientific journal)

Polyion complex micelle composed of siRNA-PEG conjugate and poly(L-lysine) for the cytoplasmic delivery of siRNA

Motoi Oishi, Nobuhiro Nishiyama, Keiji Itaka, Kazunori Kaiaoka, Yukio Nagasaki

Polymer Preprints, Japan　Vol. 54　No. 1　2005　Research paper (international conference proceedings)

Synthesis of triblock copolymers with the different structure and their efficiency as a gene carrier

Shigeto Fukushima, Kanjiro Miyata, Nobuhiro Nishiyama, Naoki Kanayama, Keiji Itaka, Yuichi Yamasaki, Kazunori Kataok

Polymer Preprints, Japan　Vol. 54　No. 1　2005　Research paper (international conference proceedings)

Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors

Nobuhiro Nishiyama, Keiji Itaka, Naoki Kanayama, Shigeto Fukushima, Kanjiro Miyata, Woo-Dong Jang, Ung-Li Chung, Yuichi Yamasaki, Kazunori Kataoka

Polymer Preprints, Japan　Vol. 54　No. 1　2005　Research paper (international conference proceedings)

Poly(ethylene glycol)-siRNA conjugate beraing ligand molecules to constract polyion complex micelles Achieving the pinpoint delivery of siRNA

Motoi Oishi, Nobuhiro Nishiyama, Keiji Itaka, Kazunori Kataoka, Yukio Nagasaki

Polymer Preprints, Japan　Vol. 54　No. 2　p. 5179-5180　2005　Research paper (international conference proceedings)

Molecular design of novel triblock copolymers and their efficiency as a gene carrier

Shigeto Fukushima, Kanjiro Miyata, Nobuhiro Nishiyama, Naoki Kanayama, Younsoo Bae, Takuya Nakagawa, Keiji Itaka, Yuichi Yamasaki, Kazunori Kataoka

Polymer Preprints, Japan　Vol. 54　No. 2　p. 5185-5186　2005　Research paper (international conference proceedings)

Design of biocompatible block catiomers directed to effective transfection with minimal toxicity

Nobuhiro Nisihiyama, Keiji Itaka, Shigeto Fukushima, Woo-Dong Jang, Naoki Kanayama, Kanjiro Miyata, Shunsaku Asano, Ung-Li Chung, Yuichi Yamasaki, Kazunori Kataoka

Polymer Preprints, Japan　Vol. 54　No. 2　p. 5108-5109　2005　Research paper (international conference proceedings)

Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery.

Kataoka K, Itaka K, Nishiyama N, Yamasaki Y, Oishi M, Nagasaki Y

Nucleic acids symposium series (2004)　No. 49　p. 17-18　2005　Research paper (scientific journal)

Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: Physicochemical properties of micelles relevant to gene transfection efficacy

D Wakebayashi, N Nishiyama, K Itaka, K Miyata, Y Yamasaki, A Harada, H Koyama, Y Nagasaki, K Kataoka

BIOMACROMOLECULES　Vol. 5　No. 6　p. 2128-2136　2004/11　Research paper (scientific journal)

Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK(a) directed to enhance intracellular gene silencing

K Itaka, N Kanayama, N Nishiyama, WD Jang, Y Yamasaki, K Nakamura, H Kawaguchi, K Kataoka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 126　No. 42　p. 13612-13613　2004/10　Research paper (scientific journal)

SRC-1 is necessary for skeletal responses to sex hormones in both males and females

T Yamada, H Kawano, K Sekine, T Matsumoto, T Fukuda, Y Azuma, K Itaka, U Chung, P Chambon, K Nakamura, S Kato, H Kawaguchi

JOURNAL OF BONE AND MINERAL RESEARCH　Vol. 19　No. 9　p. 1452-1461　2004/09　Research paper (scientific journal)

Bone morphogenetic protein 2-induced osteoblast differentiation requires smad-mediated down-regulation of Cdk6

T Ogasawara, H Kawaguchi, S Jinno, K Hoshi, K Itaka, T Takato, K Nakamura, H Okayama

MOLECULAR AND CELLULAR BIOLOGY　Vol. 24　No. 15　p. 6560-6568　2004/08　Research paper (scientific journal)

Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells

D Wakebayashi, N Nishiyama, Y Yamasaki, K Itaka, N Kanayama, A Harada, Y Nagasaki, K Kataoka

JOURNAL OF CONTROLLED RELEASE　Vol. 95　No. 3　p. 653-664　2004/03　Research paper (scientific journal)

Development of supramolecular nanocarrier of siRNA

Keiji Itaka, Kazunori Kataoka, Keiji Itaka

Drug Delivery System　Vol. 19　No. 4　p. 373-378　2004　Research paper (scientific journal)

In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine

K Itaka, A Harada, Y Yamasaki, K Nakamura, H Kawaguchi, K Kataoka

JOURNAL OF GENE MEDICINE　Vol. 6　No. 1　p. 76-84　2004/01　Research paper (scientific journal)

Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency

K Itaka, K Yamauchi, A Harada, K Nakamura, H Kawaguchi, K Kataoka

BIOMATERIALS　Vol. 24　No. 24　p. 4495-4506　2003/11　Research paper (scientific journal)

Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions

K Itaka, A Harada, K Nakamura, H Kawaguchi, K Kataoka

BIOMACROMOLECULES　Vol. 3　No. 4　p. 841-845　2002/07　Research paper (scientific journal)