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NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction
Shuhei Sakurabayashi, Kyoko Furuita, Takeshi Yamada, Noriaki Sugiura, Makoto Nomura, Takanori Nakane, Akihiro Kawamoto, Genji Kurisu, Yohei Miyanoiri, Toshimichi Fujiwara, Kazuhiko Nakatani, Chojiro Kojima
Journal of the American Chemical Society 2025/04/17 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
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The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding
Shuhei Sakurabayashi, Takeshi Yamada, Kazuhiko Nakatani
Bioorganic & Medicinal Chemistry Letters p. 129985-129985 2024/10 Research paper (scientific journal)
Publisher: Elsevier BV
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Utility of oligonucleotide in upregulating circular RNA production in a cellular model
Lu Ni, Takeshi Yamada, Kazuhiko Nakatani
2024/01/25
Publisher: Research Square Platform LLC
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NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA
Takeshi Yamada, Shuhei Sakurabayashi, Noriaki Sugiura, Hitoshi Haneoka, Kazuhiko Nakatani
Chemical Communications 2024 Research paper (scientific journal)
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A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA
Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani
Digital Discovery 2024 Research paper (scientific journal)
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Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging.
Eitaro Murakami, Masayuki Nakamori, Kazuhiko Nakatani, Tomonori Shibata, Kazuki Tainaka
Bioconjugate chemistry Vol. 34 No. 12 p. 2187-2193 2023/12/20 Research paper (scientific journal)
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A New Small Molecule DoNA Binding to CAG Repeat RNA
Qingwen Chen, Takeshi Yamada, Koichi Miyagawa, Asako Murata, Mitsuo Shoji, Kazuhiko Nakatani
Bioorganic & Medicinal Chemistry 2023/12 Research paper (scientific journal)
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Photoswitchable molecular glue for RNA: reversible photocontrol of structure and function of the ribozyme
Chikara Dohno, Maki Kimura, Yusuke Fujiwara, Kazuhiko Nakatani
Nucleic Acids Research 2023/08/24 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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Quantitative Microscopic Observation of Base–Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting
Yusuke Takashima, Yuki Komoto, Takahito Ohshiro, Kazuhiko Nakatani, Masateru Taniguchi
Journal of the American Chemical Society Vol. 145 No. 2 p. 1310-1318 2023/01/04 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
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A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31
Tomonori Shibata, Kazuhiko Nakatani
Bioorganic and Medicinal Chemistry Letters Vol. 79 2023/01/01 Research paper (scientific journal)
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Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA
Anisa Ulhusna, Asako Murata, Kazuhiko Nakatani
BIOCHEMISTRY 2022/10 Research paper (scientific journal)
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NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA
Takeshi Yamada, Kyoko Furuita, Shuhei Sakurabayashi, Makoto Nomura, Chojiro Kojima, Kazuhiko Nakatani
Nucleic Acids Research 2022/09/12 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding
Yusuke Takashima, Asako Murata, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani
ACS CHEMICAL BIOLOGY 2022/09 Research paper (scientific journal)
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Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit
Hsiu-Ting Hsu, Asako Murata, Chikara Dohno, Kazuhiko Nakatani, KungYao Chang
NUCLEIC ACIDS RESEARCH Vol. 50 No. 9 p. 5369-5383 2022/05 Research paper (scientific journal)
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HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules.
Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani
Molecular therapy. Nucleic acids Vol. 27 p. 165-174 2022/03/08 Research paper (scientific journal)
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CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy.
Yuhei Hasuike, Hana Tanaka, Terence Gall-Duncan, Mustafa Mehkary, Kazuhiko Nakatani, Christopher E Pearson, Shoji Tsuji, Hideki Mochizuki, Masayuki Nakamori
Neurobiology of disease Vol. 163 p. 105604-105604 2022/02 Research paper (scientific journal)
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Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model
Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS Vol. 58 No. 22 p. 3629-3632 2022/02 Research paper (scientific journal)
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Small Molecules Targeting Repeat Sequences Causing Neurological Disorders
Bimolendu Das, Tomonori Shibata, Kazuhiko Nakatani
Handbook of Chemical Biology of Nucleic Acids p. 1-31 2022 Part of collection (book)
Publisher: Springer Nature Singapore
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p Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases
Kazuhiko Nakatani
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES Vol. 98 No. 1 p. 30-48 2022/01 Research paper (scientific journal)
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2-Amino-1,8-naphthyridine Dimer (ANP77), a High-Affinity Binder to the Internal Loops of C/CC and T/CC Sites in Double-Stranded DNA
Bimolendu Das, Konami Nagano, Gota Kawai, Asako Murata, Kazuhiko Nakatani
JOURNAL OF ORGANIC CHEMISTRY Vol. 87 No. 1 p. 340-350 2021/12 Research paper (scientific journal)
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FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability
Amit Laxmikant Deshmukh, Marie-Christine Caron, Mohiuddin Mohiuddin, Stella Lanni, Gagan B. Panigrahi, Mahreen Khan, Worrawat Engchuan, Natalie Shum, Aisha Faruqui, Peixiang Wang, Ryan K. C. Yuen, Masayuki Nakamori, Kazuhiko Nakatani, Jean-Yves Masson, Christopher E. Pearson
CELL REPORTS Vol. 37 No. 10 p. 110078-110078 2021/12 Research paper (scientific journal)
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Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation.
Patryk Konieczny, Sanjukta Mukherjee, Ewa Stepniak-Konieczna, Katarzyna Taylor, Daria Niewiadomska, Agnieszka Piasecka, Agnieszka Walczak, Anna Baud, Chikara Dohno, Kazuhiko Nakatani, Krzysztof Sobczak
Nucleic acids research Vol. 49 No. 16 p. 9479-9495 2021/09/20 Research paper (scientific journal)
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Short Tandem Repeat Contractions during in vitro DNA Synthesis by Repeat-Binding Molecules
Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiro Sugimoto, Yuta Hishinuma, Yuri Sohma, Tomonori Shibata, Kazuhiko Nakatani
Chemistry Letters Vol. 50 No. 11 p. 1848-1851 2021/09/07 Research paper (scientific journal)
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A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules
Bimolendu Das, Asako Murata, Kazuhiko Nakatani
NUCLEIC ACIDS RESEARCH Vol. 49 No. 15 p. 8462-8470 2021/09 Research paper (scientific journal)
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Ab initio multi-level layered elongation method and its application to local interaction analysis between DNA bulge and ligand molecules
Keisuke Hisama, Yuuichi Orimoto, Anna Pomogaeva, Kazuhiko Nakatani, Yuriko Aoki
JOURNAL OF CHEMICAL PHYSICS Vol. 155 No. 4 2021/07 Research paper (scientific journal)
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Speeding drug discovery targeting RNAs: An iterative "RNA selection-compounds screening cycle" for exploring RNA-small molecule pairs
Tomoko Furuzono, Asako Murata, Satoshi Okuda, Kenji Mizutani, Tsuyoshi Adachi, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 36 2021/04 Research paper (scientific journal)
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Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.
Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani
Chemical communications (Cambridge, England) Vol. 57 No. 26 p. 3235-3238 2021/03/01 Research paper (scientific journal)
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Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction.
Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Bimolendu Das, Yusuke Takashima, Kazuhiko Nakatani
Biochemistry Vol. 60 No. 4 p. 245-249 2021/02/02 Research paper (scientific journal)
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Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model.
Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
Nature communications Vol. 12 No. 1 p. 236-236 2021/01/11 Research paper (scientific journal)
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Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer
Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymanski, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa
Chemical Science Vol. 12 No. 26 p. 9207-9220 2021 Research paper (scientific journal)
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Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat.
Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani
Biochemistry Vol. 59 No. 29 p. 2679-2683 2020/07/28 Research paper (scientific journal)
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The dimeric form of 1,3-diaminoisoquinoline derivative rescued the mis-splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model.
Kazuhiko Nakatani, Jun Matsumoto, Masayuki Nakamori, Tatsumasa Okamoto, Asako Murata, Chikara Dohno
Chemistry (Weinheim an der Bergstrasse, Germany) 2020/05/25 Research paper (scientific journal)
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Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands.
Lu Ni, Takeshi Yamada, Kazuhiko Nakatani
Chemical communications (Cambridge, England) 2020/04/28
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Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats
Mukherjee, S, Błaszczyk, L, Rypniewski, W, Falschlunger, C, Micura, R, Murata, A, Dohno, C, Nakatani, K, Kiliszek, A
Nucl. Acids Res. Vol. 47 No. 20 p. 10906-10913 2019/11 Research paper (scientific journal)
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Modulating RNA secondary and tertiary structures by mismatch binding ligands.
Murata A, Nakamori M, Nakatani K
Methods (San Diego, Calif.) 2019/05
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Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer.
Otabe T, Nagano K, Kawai G, Murata A, Nakatani K
Bioorganic & medicinal chemistry Vol. 27 No. 10 p. 2140-2148 2019/05
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A Dimeric 2,9-Diamino-1,10-phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models.
Li J, Nakamori M, Matsumoto J, Murata A, Dohno C, Kiliszek A, Taylor K, Sobczak K, Nakatani K
Chemistry (Weinheim an der Bergstrasse, Germany) Vol. 24 No. 68 p. 18115-18122 2018/12
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CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation.
Yamada T, Miki S, Ni L, Nakatani K
Chemical communications (Cambridge, England) Vol. 54 No. 93 p. 13072-13075 2018/11 Research paper (scientific journal)
Publisher: Royal Society of Chemistry (RSC)
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Expanding chemical space of DNA-binding molecules with three base-binding units.
Yagi Y, Aikawa H, Yamada T, Nakatani K
Bioorganic & medicinal chemistry letters Vol. 28 No. 17 p. 2894-2898 2018/09 Research paper (scientific journal)
Publisher: Elsevier BV
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Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.
Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K
Nucleic acids research Vol. 46 No. 16 p. 8079-8089 2018/09
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Bicyclic and tricyclic C-C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs.
Shibata T, Nakatani K
Chemical communications (Cambridge, England) Vol. 54 No. 51 p. 7074-7077 2018/06
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Restoration of Ribozyme Tertiary Contact and Function by Using a Molecular Glue for RNA
Chikara Dohno, Maki Kimura, Kazuhiko Nakatani
Angewandte Chemie - International Edition Vol. 57 No. 2 p. 506-510 2018/01/08 Research paper (scientific journal)
Publisher: Wiley-VCH Verlag
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PCR under Low Ionic Concentration Buffer Conditions
Fumie Takei, Misaki Akiyama, Kazuyuki Nobusawa, Norhayati Binti Sabani, Huanwen Han, Kazuhiko Nakatani, Ichiro Yamashita
CHEMISTRYSELECT Vol. 3 No. 3 p. 973-976 2018/01 Research paper (scientific journal)
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1,3-Di(quinolin-2-yl)guanidine binds to GGCCCC hexanucleotide repeat DNA in C9ORF72
Tomonori Shibata, Eitaro Murakami, Kazuhiko Nakatani
Bioorganic and Medicinal Chemistry Letters Vol. 28 No. 14 p. 2364-2368 2018 Research paper (scientific journal)
Publisher: Elsevier Ltd
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Synthesis of Naphthyridine Dimers with Conformational Restriction and Binding to DNA and RNA
Kazuhiko Nakatani, Nozomi Natsuhara, Yuki Mori, Sanjukta Mukherjee, Bimolendu Das, Asako Murata
CHEMISTRY-AN ASIAN JOURNAL Vol. 12 No. 23 p. 3077-3087 2017/12 Research paper (scientific journal)
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Synthetic ligand promotes gene expression by affecting GC sequence in promoter
Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 27 No. 15 p. 3391-3394 2017/08 Research paper (scientific journal)
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Design and Synthesis of Cyclic Mismatch-Binding Ligands (CMBLs) with Variable Linkers by Ring-Closing Metathesis and their Photophysical and DNA Repeat Binding Properties
Sanjukta Mukherjee, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 23 No. 47 p. 11385-11396 2017/08 Research paper (scientific journal)
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Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G-G Mismatch DNA
Takeshi Yamada, Shouta Miki, Anisa Ul'Husna, Akiko Michikawa, Kazuhiko Nakatani
ORGANIC LETTERS Vol. 19 No. 16 p. 4163-4166 2017/08 Research paper (scientific journal)
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Amphiphilic DNA tiles for controlled insertion and 2D assembly on fluid lipid membranes: the effect on mechanical properties
Chikara Dohno, Shingo Makishi, Kazuhiko Nakatani, Sonia Contera
NANOSCALE Vol. 9 No. 9 p. 3051-3058 2017/03 Research paper (scientific journal)
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A Ligand That Targets CUG Trinucleotide Repeats
Jinxing Li, Jun Matsumoto, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 22 No. 42 p. 14881-14889 2016/10 Research paper (scientific journal)
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BzDANP, a Small-Molecule Modulator of Pre-miR-29a Maturation by Dicer
Asako Murata, Takahiro Otabe, Jinhua Zhang, Kazuhiko Nakatani
ACS CHEMICAL BIOLOGY Vol. 11 No. 10 p. 2790-2796 2016/10 Research paper (scientific journal)
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Fluorescence Probe for Detecting CCG Trinucleotide Repeat DNA Expansion and Slip-Out
Tomonori Shibata, Kazuhiko Nakatani
CHEMBIOCHEM Vol. 17 No. 18 p. 1685-1688 2016/09 Research paper (scientific journal)
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Cyclic mismatch binding ligand CMBL4 binds to the 5 '-T-3 '/5 '-GG-3 ' site by inducing the flipping out of thymine base
Sanjukta Mukherjee, Chikara Dohno, Kaori Asano, Kazuhiko Nakatani
NUCLEIC ACIDS RESEARCH Vol. 44 No. 15 p. 7090-7099 2016/09 Research paper (scientific journal)
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Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection
Huixin Chen, Mariya Parimelalagan, Fumie Takei, Hapuarachchige Chanditha Hapuarachchi, Evelyn Siew-Chuan Koay, Lee Ching Ng, Phui San Ho, Kazuhiko Nakatani, Justin Jang Hann Chu
PLoS Neglected Tropical Diseases Vol. 10 No. 8 2016/08/29 Research paper (scientific journal)
Publisher: Public Library of Science
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Synthesis of 1H-pyrrolo[3,2-h]quinoline-8-amine derivatives that target CTG trinucleotide repeats
Jun Matsumoto, Jinxing Li, Chikara Dohno, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 26 No. 15 p. 3761-3764 2016/08 Research paper (scientific journal)
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Naphthyridine-Benzoazaquinolone: Evaluation of a Tricyclic System for the Binding to (CAG)(n) Repeat DNA and RNA
Jinxing Li, Akihiro Sakata, Hanping He, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani
CHEMISTRY-AN ASIAN JOURNAL Vol. 11 No. 13 p. 1971-1981 2016/07 Research paper (scientific journal)
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Synthesis and Photophysical Properties of Fluorescence Molecular Probe for Turn-ON-Type Detection of Cytosine Bulge DNA
Rajiv Kumar Verma, Fumie Takei, Kazuhiko Nakatani
ORGANIC LETTERS Vol. 18 No. 13 p. 3170-3173 2016/07 Research paper (scientific journal)
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Non-covalent Modification of Double-Stranded DNA at the Mismatch and Bulged Site
Chikara Dohno, Kazuhiko Nakatani
Nucleic Acids and Molecular Biology p. 189-207 2016/04/05 Part of collection (book)
Publisher: Springer International Publishing
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Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29a
Takeo Fukuzumi, Asako Murata, Haruo Aikawa, Yasue Harada, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 21 No. 47 p. 16859-16867 2015/11 Research paper (scientific journal)
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2-Aminophenanthroline dimer stabilized the C-C mismatched duplex DNA
Jinxing Li, Jun Matsumoto, Takahiro Otabe, Chikara Dohno, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 23 No. 4 p. 753-758 2015/02 Research paper (scientific journal)
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Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes
Li-Ping Bai, Masaki Hagihara, Kazuhiko Nakatani, Zhi-Hong Jiang
SCIENTIFIC REPORTS Vol. 4 2014/10 Research paper (scientific journal)
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Modulation of binding properties of amphiphilic DNA containing multiple dodecyl phosphotriester linkages to lipid bilayer membrane
Shingo Makishi, Tomonori Shibata, Masatsugu Okazaki, Chikara Dohno, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 24 No. 15 p. 3578-3581 2014/08 Research paper (scientific journal)
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The Chemistry of Polymerase Chain Reaction-Development of the PCR Method Using New Modified Primers
Fumie Takei, Kazuhiko Nakatani
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 72 No. 4 p. 370-381 2014/04 Research paper (scientific journal)
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Formation of a Ligand- Assisted Complex of Two RNA Hairpin Loops
Changfeng Hong, Takahiro Otabe, Saki Matsumoto, Chikara Dohno, Asako Murata, Masaki Hagihara, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 20 No. 18 p. 5282-5287 2014/04 Research paper (scientific journal)
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Detection of hepatitis C virus by single-step hairpin primer RT-PCR
Fumie Takei, Hideki Tani, Yoshiharu Matsuura, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 24 No. 1 p. 394-396 2014/01 Research paper (scientific journal)
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Development of photoswitchable RNA aptamer-ligand complexes
Gosuke Hayashi, Kazuhiko Nakatani
Methods in Molecular Biology Vol. 1111 p. 29-40 2014 Research paper (scientific journal)
Publisher: Humana Press Inc.
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Facile electrochemical biosensor based on a new bifunctional probe for label-free detection of CGG trinucleotide repeat
Hanping He, Jingping Xia, Xiaoqian Peng, Gang Chang, Xiuhua Zhang, Yafen Wang, Kazuhiko Nakatani, Zhaowen Lou, Shengfu Wang
BIOSENSORS & BIOELECTRONICS Vol. 49 p. 282-289 2013/11 Research paper (scientific journal)
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Fluorescent indicator displacement assay of ligands targeting 10 microRNA precursors
Asako Murata, Yasue Harada, Takeo Fukuzumi, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 21 No. 22 p. 7101-7106 2013/11 Research paper (scientific journal)
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A Synthetic Riboswitch that Operates using a Rationally Designed Ligand-RNA Pair
Chikara Dohno, Izumi Kohyama, Maki Kimura, Masaki Hagihara, Kazuhiko Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 52 No. 38 p. 9976-9979 2013/09 Research paper (scientific journal)
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Ligand-inducible formation of RNA pseudoknot
Saki Matsumoto, Changfeng Hong, Takahiro Otabe, Asako Murata, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 23 No. 12 p. 3539-3541 2013/06 Research paper (scientific journal)
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Selective recognition of G-G mismatch using the double functional probe with electrochemical active ferrocenyl
Hanping He, Jingping Xia, Gang Chang, Xiaoqian Peng, Zhaowen Lou, Kazuhiko Nakatani, Xiang Zhou, Shengfu Wang
BIOSENSORS & BIOELECTRONICS Vol. 42 p. 36-40 2013/04 Research paper (scientific journal)
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A novel DANP-coupled hairpin RT-PCR for rapid detection of Chikungunya virus
Huixin Chen, Fumie Takei, Evelyn Siew-Chuan Koay, Kazuhiko Nakatani, Justin Jang Hann Chu
Journal of Molecular Diagnostics Vol. 15 No. 2 p. 227-233 2013/03 Research paper (scientific journal)
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A dimeric form of N-methoxycarbonyl-2-amino-1,8-naphthyridine bound to the A-A mismatch in the CAG/CAG base triad in dsRNA
Kazuhiko Nakatani, Mariko Toda, Hanping He
Bioorganic and Medicinal Chemistry Letters Vol. 23 No. 2 p. 558-561 2013/01/15 Research paper (scientific journal)
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Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer: Targeting secondary structures of pre-miRNA by small molecules
Asako Murata, Takeo Fukuzumi, Shiori Umemoto, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 23 No. 1 p. 252-255 2013/01 Research paper (scientific journal)
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Ligand-induced electron spin-assembly on a DNA tile
Hiroshi Atsumi, Shigeaki Nakazawa, Chikara Dohno, Kazunobu Sato, Takeji Takui, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS Vol. 49 No. 57 p. 6370-6372 2013 Research paper (scientific journal)
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G-quadruplex formation of entirely hydrophobic DNA in organic solvents
Tomonori Shibata, Chikara Dohno, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS Vol. 49 No. 48 p. 5501-5503 2013 Research paper (scientific journal)
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Activation of prokaryotic translation by antisense oligonucleotides binding to coding region of mRNA
Gosuke Hayashi, Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 429 No. 1-2 p. 105-110 2012/12 Research paper (scientific journal)
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Amphiphilic DNA Duplex Stabilized by a Hydrophobic Zipper
Chikara Dohno, Tomonori Shibata, Masatsugu Okazaki, Shingo Makishi, Kazuhiko Nakatani
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY No. 27 p. 5317-5323 2012/09 Research paper (scientific journal)
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Structure-Activity Studies on the Fluorescent Indicator in a Displacement Assay for the Screening of Small Molecules Binding to RNA
Shiori Umemoto, Seongwang Im, Jinhua Zhang, Masaki Hagihara, Asako Murata, Yasue Harada, Takeo Fukuzumi, Takahiro Wazaki, Shin-ichi Sasaoka, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 18 No. 32 p. 9999-10008 2012/08 Research paper (scientific journal)
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Competitive Allele-Specific Hairpin Primer PCR for Extremely High Allele Discrimination in Typing of Single Nucleotide Polymorphisms
Fumie Takei, Masako Igarashi, Yoshimi Oka, Yusuke Koga, Kazuhiko Nakatani
CHEMBIOCHEM Vol. 13 No. 10 p. 1409-1412 2012/07 Research paper (scientific journal)
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Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence
Chikara Dohno, Izumi Kohyama, Changfeng Hong, Kazuhiko Nakatani
NUCLEIC ACIDS RESEARCH Vol. 40 No. 6 p. 2771-2781 2012/03 Research paper (scientific journal)
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A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats
Masaki Hagihara, Hanping He, Maki Kimura, Kazuhiko Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 22 No. 5 p. 2000-2003 2012/03 Research paper (scientific journal)
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Tandem Arrays of TEMPO and Nitronyl Nitroxide Radicals with Designed Arrangements on DNA
Hiroshi Atsumi, Kensuke Maekawa, Shigeaki Nakazawa, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani
CHEMISTRY-A EUROPEAN JOURNAL Vol. 18 No. 1 p. 178-183 2012/01 Research paper (scientific journal)
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Molecular-Glue-Triggered DNA Assembly To Form a Robust and Photoresponsive Nano-Network
Chunyan Wang, Fang Pu, Youhui Lin, Jinsong Ren, Chikara Dohn, Kazuhiko Nakatani, Xiaogang Qu
CHEMISTRY-A EUROPEAN JOURNAL Vol. 17 No. 29 p. 8189-8194 2011/07 Research paper (scientific journal)
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Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats
Masaki Hagihara, Hanping He, Kazuhiko Nakatani
CHEMBIOCHEM Vol. 12 No. 11 p. 1686-1689 2011/07 Research paper (scientific journal)
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Ligand inducible assembly of a DNA tetrahedron
Chikara Dohno, Hiroshi Atsumi, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS Vol. 47 No. 12 p. 3499-3501 2011 Research paper (scientific journal)
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Ligand-Assisted Complex Formation of Two DNA Hairpin Loops
Changfeng Hong, Masaki Hagihara, Kazuhiko Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 50 No. 19 p. 4390-4393 2011 Research paper (scientific journal)
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Control of DNA hybridization by photoswitchable molecular glue
Chikara Dohno, Kazuhiko Nakatani
CHEMICAL SOCIETY REVIEWS Vol. 40 No. 12 p. 5718-5729 2011
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Antisense-Induced Guanine Quadruplexes Inhibit Reverse Transcription by HIV-1 Reverse Transcriptase
Masaki Hagihara, Lisa Yamauchi, Akiko Seo, Keisuke Yoneda, Mayo Senda, Kazuhiko Nakatani
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 132 No. 32 p. 11171-11178 2010/08 Research paper (scientific journal)
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Discrimination of N6-methyl adenine in a specific DNA sequence
Chikara Dohno, Tomonori Shibata, Kazuhiko Nakatani
CHEMICAL COMMUNICATIONS Vol. 46 No. 30 p. 5530-5532 2010 Research paper (scientific journal)
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Development of molecules binding to mismatched base pairs: Application to the detection of gene mutation and PCR monitoring
Kazuhiko Nakatani
Seikagaku Vol. 82 No. 7 p. 646-651 2010 Research paper (scientific journal)
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Ligand Binding to Tandem G Quadruplexes from Human Telomeric DNA
Li-Ping Bai, Masaki Hagihara, Zhi-Hong Jiang, Kazuhiko Nakatani
CHEMBIOCHEM Vol. 9 No. 16 p. 2583-2587 2008/11 Research paper (scientific journal)
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The crystallographic study of left-handed Z-DNA d(CGCGCG)(2) and thermine complexes crystallized at various temperatures and at various concentration of cations
Hirofumi Ohishi, Mamiko Odoko, Da-Yang Zhou, Yoshitaka Tozuka, Nobuo Okabe, Kazuhiko Nakatani, Toshimasa Ishida, Kazmierz Grzeskowlak
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 368 No. 2 p. 382-387 2008/04 Research paper (scientific journal)
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Polyamines stabilize left-handed Z-DNA: Using X-ray crystallographic analysis, we have found a new type of polyamine (PA) that stabilizes left-handed Z-DNA
Hirofumi Ohishi, Mamiko Odoko, Kazimierz Grzeskowiak, Yoichi Hiyama, Koji Tsukamoto, Naoyoshi Maezaki, Toshimasa Ishida, Tetsuaki Tanaka, Nobuo Okabe, Keiichi Fukuyama, Da-Yang Zhou, Kazuhiko Nakatani
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 366 No. 2 p. 275-280 2008/02 Research paper (scientific journal)
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Evaluation of mismatch-binding ligands as inhibitors for Rev-RRE interaction
Kazuhiko Nakatani, Souta Horie, Yuki Goto, Akio Kobori, Shinya Hagihara
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 14 No. 15 p. 5384-5388 2006/08 Research paper (scientific journal)
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Control of DNA hybridization by photoswitchable mismatch binding ligands.
Dohno C, Uno SN, Nakatani K
Nucleic acids symposium series (2004) No. 50 p. 87-88 2006
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Inhibition of DNA replication by a d(CAG) repeat binding ligand.
Hagihara M, Nakatani K
Nucleic acids symposium series (2004) No. 50 p. 147-148 2006
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Measurement of circular dichroism and structural chemical research of d(CG)6 and d(TA)6.
Tozuka Y, Yoshikawa Y, Ohishi H, Kobayashi Y, Da-Yang Z, Nakatani K
Nucleic acids symposium series (2004) No. 50 p. 227-228 2006
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N,N '-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA
H Suda, A Kobori, JH Zhang, G Hayashi, K Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 13 No. 14 p. 4507-4512 2005/07 Research paper (scientific journal)
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2P137 NMR structural analysis of the CGG/CGG containing DNA complexed with the recognition drugs
Nomura M., Hagihara S., Goto Y., Nakatani K., Kojima C.
Seibutsu Butsuri Vol. 45 2005
Publisher: The Biophysical Society of Japan General Incorporated Association
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A new ligand binding to G-G mismatch having improved thermal and alkaline stability
T Peng, T Murase, Y Goto, A Kobori, K Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 15 No. 2 p. 259-262 2005/01 Research paper (scientific journal)
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Binding of naphthyridine carbamate dimer to the (CGG)(n) repeat results in the disruption of the G-C base pairing
T Peng, K Nakatani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 44 No. 44 p. 7280-7283 2005 Research paper (scientific journal)
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Molecular labeling of the CGG trinucleotide repeat.
Peng T, Nakatani K
Nucleic acids symposium series (2004) No. 49 p. 39-40 2005
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Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.
Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C
Nucleic acids symposium series (2004) No. 49 p. 49-50 2005 Research paper (scientific journal)
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NMR structural analysis of the G.G mismatch DNA complexed with naphthyridine-dimer.
Nomura M, Hagihara S, Goto Y, Nakatani K, Kojima C
Nucleic acids symposium series (2004) No. 49 p. 213-214 2005 Research paper (scientific journal)
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Application of L-DNA as a molecular tag.
Hayashi G, Hagihara M, Nakatani K
Nucleic acids symposium series (2004) No. 49 p. 261-262 2005
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Chemistry challenges in SNP typing
K Nakatani
CHEMBIOCHEM Vol. 5 No. 12 p. 1623-1633 2004/12
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2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges
A Kobori, T Murase, H Suda, Saito, I, K Nakatani
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 14 No. 13 p. 3431-3433 2004/07 Research paper (scientific journal)
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The binding of guanine-guanine mismatched DNA to naphthyridine dimer immobilized sensor surfaces: kinetic aspects
K Nakatani, A Kobori, H Kumasawa, Y Goto, Saito, I
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 12 No. 12 p. 3117-3123 2004/06 Research paper (scientific journal)
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Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linkers
K Nakatani, A Kobori, H Kumasawa, Saito, I
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 14 No. 5 p. 1105-1108 2004/03 Research paper (scientific journal)
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Detection of guanine-adenine mismatches by surface plasmon resonance sensor carrying naphthyridine-azaquinolone hybrid on the surface
S Hagihara, H Kumasawa, Y Goto, G Hayashi, A Kobori, Saito, I, K Nakatani
NUCLEIC ACIDS RESEARCH Vol. 32 No. 1 p. 278-286 2004/01 Research paper (scientific journal)
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The SPR sensor detecting cytosine-cytosine mismatches
A Kobori, S Horie, H Suda, Saito, I, K Nakatani
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 126 No. 2 p. 557-562 2004/01 Research paper (scientific journal)
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Separation of mismatched DNA by using the affinity column immobilizing mismatch-binding ligands.
Goto Y, Kobori A, Suda H, Nakatani K
Nucleic acids symposium series (2004) No. 48 p. 123-124 2004 Research paper (scientific journal)
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SPR fingerprinting of mismatched base pair.
Kobori A, Peng T, Hayashi G, Nakatani K
Nucleic acids symposium series (2004) No. 48 p. 129-130 2004 Research paper (scientific journal)
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Hole trapping at N-6-cyclopropyideoxyadenosine suggests a direct contribution of adenine bases to hole transport through DNA
C Dohno, A Ogawa, K Nakatani, Saito, I
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 125 No. 34 p. 10154-10155 2003/08 Research paper (scientific journal)
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Affinity labeling of a single guanine bulge
K Nakatani, S Horie, Saito, I
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 125 No. 30 p. 8972-8973 2003/07 Research paper (scientific journal)
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Assessment of the sequence dependency for the binding of 2-aminonaphthyridine to the guanine bulge
K Nakatani, S Horie, T Murase, S Hagihara, Saito, I
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 11 No. 10 p. 2347-2353 2003/05 Research paper (scientific journal)
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Formation and destruction of the guanine quartet in solution observed by cold-spray ionization mass spectrometry.
Sakamoto S, Nakatani K, Saito I, Yamaguchi K
Chemical communications (Cambridge, England) No. 6 p. 788-789 2003/03
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Induction of a remarkable conformational change in a human telomeric sequence by the binding of naphthyridine dimer: Inhibition of the elongation of a telomeric repeat by telomerase
K Nakatani, S Hagihara, S Sando, S Sakamoto, K Yamaguchi, C Maesawa, Saito, I
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 125 No. 3 p. 662-666 2003/01 Research paper (scientific journal)
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Detection of the C-C mismatched base pair by small ligands.
Kobori A, Suda H, Nakatani K, Saito I
Nucleic acids research. Supplement (2001) No. 3 p. 131-132 2003 Research paper (scientific journal)
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The binding of naphthyridine tetramer to guanine-rich sequences.
Goto Y, Hagihara S, Kobori A, Nakatani K, Saito I
Nucleic acids research. Supplement (2001) No. 3 p. 133-134 2003 Research paper (scientific journal)
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2,6-Diaminonaphthyridine derivatives bind to a single nucleotide bulge in DNA.
Suda H, Hagihara S, Kobori A, Nakatani K, Saito I
Nucleic acids research. Supplement (2001) No. 3 p. 139-140 2003 Research paper (scientific journal)
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Guanine of the third strand of C·G*G triplex serves as an effective hole trap
Chikara Dohno, Kazuhiko Nakatani, Isao Saito
Journal of the American Chemical Society Vol. 124 No. 49 p. 14580-14585 2002/12/11 Research paper (scientific journal)
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N(2)-phenyldeoxyguanosine: modulation of the chemical properties of deoxyguanosine toward one-electron oxidation in DNA.
Nakatani K, Dohno C, Saito I
Journal of the American Chemical Society Vol. 124 No. 24 p. 6802-6803 2002/06
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Chemically induced hairpin formation in DNA monolayers
EA Smith, M Kyo, H Kumasawa, K Nakatani, Saito, I, RM Corn
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 124 No. 24 p. 6810-6811 2002/06 Research paper (scientific journal)
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Photochemistry of benzophenone immobilized in a major groove of DNA: formation of thermally reversible interstrand cross-link.
Nakatani K, Yoshida T, Saito I
Journal of the American Chemical Society Vol. 124 No. 10 p. 2118-2119 2002/03
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Suppression of DNA-mediated charge transport by BamHI binding
K Nakatani, C Dohno, A Ogawa, Saito, I
CHEMISTRY & BIOLOGY Vol. 9 No. 3 p. 361-366 2002/03 Research paper (scientific journal)
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Recognition of DNA mismatch structures.
Hagihara S, Nakatani K, Saito I
Nucleic acids research. Supplement (2001) No. 2 p. 127-128 2002
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Binding analysis between naphthyridine dimers and GG mismatch DNA.
Kobori A, Kumasawa H, Nakatani K, Saito I
Nucleic acids research. Supplement (2001) No. 2 p. 185-186 2002 Research paper (scientific journal)
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Synthesis of an ABC Ring Analogue of Kapurimycin A3 as an Effective DNA Alkylating Agent
Kazuhiko Nakatani, Akimitsu Okamoto, Isao Saito
Angewandte Chemie (International Edition in English) Vol. 36 No. 24 p. 2794-2797 1997 Research paper (scientific journal)
Publisher: Wiley-VCH Verlag
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New Aspects of α-Diazocarbonyl Compounds From Construction of the Novel Carbon Framework to the Photoinduced DNA Cleavage
NAKATANI Kazuhiko
J. Synth. Org. Chem. Jpn. Vol. 53 No. 12 p. 1068-1076 1995/12/01
Publisher: The Society of Synthetic Organic Chemistry, Japan
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Synthesis of Asperuloside Aglucon Silyl Ether and Garjasmine from (+)-Genipin via Gardenoside Aglucon Disilyl Ether as a Common Intermediate
NAKATANI Kazuhiko, HIRAISHI Atsushi, HAN Qingjun, ISOE Sachihiko
Chemistry Letters Vol. 1992 No. 9 p. 1851-1854 1992/09/05
Publisher: The Chemical Society of Japan