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Solid-Phase Oligosaccharide Synthesis with Highly Complexed Peptidoglycan Fragments
Yuichiro Kadonaga, Ning Wang, Atsushi Shimoyama, Yukari Fujimoto, Koichi Fukase
Molecules 2025/06/28 Research paper (scientific journal)
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Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, Atsushi Toyoshima, Hiromitsu Haba, Yoshikatsu Kanai, Koichi Fukase
International Journal of Molecular Sciences Vol. 25 No. 22 p. 12386-12386 2024/11/18 Research paper (scientific journal)
Publisher: MDPI AG
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Immunomodulatory of sesquiterpenoids and sesquiterpenoid dimers-based toll-like receptor 4 (TLR4) from Dysoxylum parasiticum stem bark
Al Arofatus Naini, Tri Mayanti, Erina Hilmayanti, Xuhao Huang, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Unang Supratman
Scientific Reports Vol. 14 2024/07/06 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Chemical Synthesis of Lipid A and Its Development as a Vaccine Adjuvant
Atsushi Shimoyama
Journal of Synthetic Organic Chemistry, Japan Vol. 82 No. 5 p. 522-534 2024/05/01 Research paper (scientific journal)
Publisher: The Society of Synthetic Organic Chemistry, Japan
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Chemical synthesis of Acetobacter pasteurianus lipid A with a unique tetrasaccharide backbone and evaluation of its immunological functions.
Haruki Yamaura, Atsushi Shimoyama, Koji Hosomi, Kazuya Kabayama, Jun Kunisawa, Koichi Fukase
Angewandte Chemie (International ed. in English) 2024/04/06 Research paper (scientific journal)
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Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum.
Al Arofatus Naini, Tri Mayanti, Rani Maharani, Desi Harneti, Nurlelasari, Kindi Farabi, Sofa Fajriah, Erina Hilmayanti, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Sirriporn Jungsuttiwong, Thomas Alexander Kyle Prescott, Unang Supratman
Phytochemistry p. 114009-114009 2024/02/09 Research paper (scientific journal)
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アスタチン標識金ナノ粒子の全身投与後の体内動態
加藤 弘樹, 角永 悠一郎, 大江 一弘, 黄 栩昊, Erina Hilmayanti, 下山 敦史, 樺山 一哉, Yin Xiaojie, 羽場 宏光, 豊嶋 厚史, 深瀬 浩一
核医学 Vol. 61 No. Suppl. p. S150-S150 2024
Publisher: (一社)日本核医学会
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アスタチン標識金ナノ粒子の腫瘍内投与に関する薬剤の最適化
加藤 弘樹, 島本 博彰, 角永 悠一郎, 大江 一弘, 下山 敦史, 樺山 一哉, Yin Xiaojie, 羽場 宏光, 豊嶋 厚史, 深瀬 浩一
核医学 Vol. 61 No. Suppl. p. S150-S150 2024
Publisher: (一社)日本核医学会
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Diacetyl strategy for synthesis of NHAc containing glycans: enhancing glycosylation reactivity via diacetyl imide protection
Koichi Fukase, Yoshiyuki Manabe, Atsushi Shimoyama
Frontiers in Chemistry Vol. 11 2023/12/05 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue
Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
International Immunology 2023/11/25 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis
Puja Kumari, Swathy O. Vasudevan, Ashley J. Russo, Skylar S. Wright, Víctor Fraile-Ágreda, Dylan Krajewski, Evan R. Jellison, Ignacio Rubio, Michael Bauer, Atsushi Shimoyama, Koichi Fukase, Yuanpeng Zhang, Joel S. Pachter, Sivapriya Kailasan Vanaja, Vijay A. Rathinam
Nature Cell Biology 2023/11/16 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Bacterial Glycolipid Lipid As and Their Potential as Adjuvants
Atsushi Shimoyama, Koichi Fukase
Carbohydrate‐Based Therapeutics p. 111-130 2023/09/05 Part of collection (book)
Publisher: Wiley
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Chemical Synthesis and Immunological Functions of Bacterial Lipid A for Vaccine Adjuvant Development and Bacterial-Host Chemical Ecology Research
Atsushi Shimoyama
New Tide of Natural Product Chemistry p. 77-100 2023/06/20 Part of collection (book)
Publisher: Springer Nature Singapore
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Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine
Ayaka Aso, Hinako Nabetani, Yoshifumi Matsuura, Yuichiro Kadonaga, Yoshifumi Shirakami, Tadashi Watabe, Taku Yoshiya, Masayoshi Mochizuki, Kazuhiro Ooe, Atsuko Kawakami, Naoya Jinno, Atsushi Toyoshima, Hiromitsu Haba, Yang Wang, Jens Cardinale, Frederik Lars Giesel, Atsushi Shimoyama, Kazuko Kaneda-Nakashima, Koichi Fukase
International Journal of Molecular Sciences Vol. 24 No. 10 p. 8701-8701 2023/05/12 Research paper (scientific journal)
Publisher: MDPI AG
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ガングリオシドGM3分子種による炎症病態の制御
井ノ口 仁一, 狩野 裕考, 稲森 啓一郎, 石川 潮, 新田 昂大, 樺山 一哉, 黄 栩昊, 下山 敦史, 深瀬 浩一
脂質生化学研究 Vol. 65 p. 221-223 2023/05
Publisher: 日本脂質生化学会
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アスタチン211標識金ナノ粒子の腫瘍内投与 マウス舌癌モデルに対する局所投与の効果
島本 博彰, 加藤 弘樹, 片山 大輔, 角永 悠一郎, 大江 一弘, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一, 村上 秀明
歯科放射線 Vol. 63 No. 増刊 p. 41-41 2023/04
Publisher: (NPO)日本歯科放射線学会
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TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells
Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J. Ishii, Shizuo Akira, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
International Immunopharmacology Vol. 117 p. 109852-109852 2023/04 Research paper (scientific journal)
Publisher: Elsevier BV
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Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning
Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa
Frontiers in Bioscience-Landmark Vol. 28 No. 1 p. 15-15 2023/01/17 Research paper (scientific journal)
Publisher: IMR Press
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悪性腫瘍腹腔内播種治療のためのアスタチン標識金ナノ粒子の最適化
加藤 弘樹, 角永 悠一郎, 大江 一弘, 黄 栩昊, Hilmayanti Erina, 下山 敦史, 樺山 一哉, 殷 小杰, 羽場 宏光, 豊嶋 厚史, 深瀬 浩一
核医学 Vol. 60 No. Suppl. p. S201-S201 2023
Publisher: (一社)日本核医学会
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Dysoticans F–H: three unprecedented dimeric cadinanes from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark
Al Arofatus Naini, Tri Mayanti, Rani Maharani, Sofa Fajriah, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Sirriporn Jungsuttiwong, Unang Supratman
RSC Advances Vol. 13 No. 14 p. 9370-9376 2023 Research paper (scientific journal)
Publisher: Royal Society of Chemistry (RSC)
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Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As
Atsushi Shimoyama, Koichi Fukase
Methods in Molecular Biology Vol. 2613 p. 33-53 2023/01 Part of collection (book)
Publisher: Springer US
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Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha-Particle Therapy via Intravenous Injection
Xuhao Huang, Kazuko Kaneda-Nakashima, Yuichiro Kadonaga, Kazuya Kabayama, Atsushi Shimoyama, Kazuhiro Ooe, Hiroki Kato, Atsushi Toyoshima, Atsushi Shinohara, Hiromitsu Haba, Yang Wang, Koichi Fukase
Pharmaceutics Vol. 14 No. 12 p. 2705-2705 2022/12/02 Research paper (scientific journal)
Publisher: MDPI AG
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Limonoids with anti-inflammatory activity: A review
Erina Hilmayanti, Nurlelasari, Unang Supratman, Kazuya Kabayama, Atsushi Shimoyama, Koichi Fukase
Phytochemistry Vol. 204 p. 113469-113469 2022/12 Research paper (scientific journal)
Publisher: Elsevier BV
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Development of Adjuvants Based on Parasitic and Symbiotic Bacterial Lipid A
Atsushi Shimoyama
Trends in Glycoscience and Glycotechnology Vol. 34 No. 202 p. E101-E105 2022/10/25 Research paper (scientific journal)
Publisher: Forum: Carbohydrates Coming of Age
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Substrate Study for Dihydroxyboryl Astatine Substitution Reaction with Fibroblast Activation Protein Inhibitor (FAPI)
Ayaka Aso, Kazuko Kaneda-Nakashima, Hinako Nabetani, Yuichiro Kadonaga, Yoshifumi Shirakami, Tadashi Watabe, Taku Yoshiya, Masayoshi Mochizuki, Yuki Koshino, Kazuhiro Ooe, Atsuko Kawakami, Naoya Jinno, Atsushi Toyoshima, Hiromitsu Haba, Yang Wang, Jens Cardinale, Frederik L. Giesel, Atsushi Shimoyama, Koichi Fukase
Chemistry Letters Vol. 51 No. 11 p. 1091-1094 2022/09/29 Research paper (scientific journal)
Publisher: The Chemical Society of Japan
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低侵襲治療を目指した短寿命アルファ線核医学治療薬の開発(Development of short-lived alpha-emitting nuclear medicine aiming at minimally invasive cancer treatment)
兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 篠原 厚, 深瀬 浩一
日本癌学会総会記事 Vol. 81回 p. J-1008 2022/09 Research paper (other academic)
Publisher: (一社)日本癌学会
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アスタチン標識金ナノ粒子の腹腔内投与における動態と生体への影響
加藤 弘樹, 片山 大輔, 大江 一弘, 角永 悠一郎, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一, 畑澤 順
核医学 Vol. 59 No. Suppl. p. S471-S471 2022/08 Research paper (other academic)
Publisher: (一社)日本核医学会
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アスタチン標識金ナノ粒子の腹腔内投与による悪性腫瘍腹腔内播種の治療効果
加藤 弘樹, 片山 大輔, 大江 一弘, 角永 悠一郎, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一, 畑澤 順
核医学 Vol. 59 No. Suppl. p. S471-S471 2022/08 Research paper (other academic)
Publisher: (一社)日本核医学会
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RI標識ナノ粒子の局所投与によるがん治療研究
角永 悠一郎, 加藤 弘樹, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一
放射線生物研究 Vol. 57 No. 1 p. 16-30 2022/03
Publisher: 放射線生物研究会
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Revisiting Glycosylations Using Glycosyl Fluoride by BF3·Et2O: Activation of Disarmed Glycosyl Fluorides with High Catalytic Turnover
Yoshiyuki Manabe, Takuya Matsumoto, Yuka Ikinaga, Yuya Tsutsui, Shota Sasaya, Yuichiro Kadonaga, Akihito Konishi, Makoto Yasuda, Tomoya Uto, Changhao Dai, Kumpei Yano, Atsushi Shimoyama, Ayana Matsuda, Koichi Fukase
Organic Letters Vol. 24 No. 1 p. 6-10 2021/12/21 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
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Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
Dawei Guo, Himansha Singh, Atsushi Shimoyama, Charlotte Guffick, Yakun Tang, Sam M. Rowe, Timothy Noel, David R. Spring, Koichi Fukase, Hendrik W. van Veen
Communications Biology Vol. 4 No. 1 2021/12 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine
Zilai Liu, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Xiao Sun, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Davie Kenneth, Azusa Saika, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Frontiers in Pharmacology Vol. 12 p. 763657-763657 2021/10/22 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Lipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants
Atsushi Shimoyama, Koichi Fukase
Molecules Vol. 26 No. 20 p. 6294-6294 2021/10/18 Research paper (scientific journal)
Publisher: MDPI AG
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局所投与による癌増殖抑制のためのアスタチン標識金ナノ粒子の最適化
加藤 弘樹, 片山 大輔, 大江 一弘, 角永 悠一郎, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一, 畑澤 順
核医学 Vol. 58 No. Suppl. p. S218-S218 2021/10
Publisher: (一社)日本核医学会
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アスタチン-211標識金ナノ粒子局所投与による癌増殖抑制
片山 大輔, 加藤 弘樹, 大江 一弘, 角永 悠一郎, 黄 栩昊, 下山 敦史, 樺山 一哉, 深瀬 浩一, 畑澤 順
核医学 Vol. 58 No. Suppl. p. S219-S219 2021/10
Publisher: (一社)日本核医学会
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万能治療を目指した短寿命アルファ線核医学治療薬の開発
兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 深瀬 浩一, 篠原 厚
日本癌学会総会記事 Vol. 80回 p. [J19-3] 2021/09
Publisher: (一社)日本癌学会
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Conjugation Strategies for Development of Bioactive Middle Molecules
Yoshiyuki Manabe, Atushi Shimoyama, Kazuya Kabayama, Koichi Fukase
Middle Molecular Strategy p. 3-20 2021/07/14 Part of collection (book)
Publisher: Springer Singapore
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Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses
Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Takahiro Nagatake, Yukari Fujimoto, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Frontiers in Immunology Vol. 12 p. 699349-699349 2021/07/01 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy
Hiroki Kato, Xuhao Huang, Yuichiro Kadonaga, Daisuke Katayama, Kazuhiro Ooe, Atsushi Shimoyama, Kazuya Kabayama, Atsushi Toyoshima, Atsushi Shinohara, Jun Hatazawa, Koichi Fukase
Journal of Nanobiotechnology Vol. 19 No. 1 p. 223-223 2021/07 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis : Complete Structure Determination and Chemical Synthesis of Its Lipid A
Atsushi Shimoyama, Flaviana Di Lorenzo, Haruki Yamaura, Keisuke Mizote, Angelo Palmigiano, Molly D. Pither, Immacolata Speciale, Tomoya Uto, Seiji Masui, Luisa Sturiale, Domenico Garozzo, Koji Hosomi, Naoko Shibata, Kazuya Kabayama, Yukari Fujimoto, Alba Silipo, Jun Kunisawa, Hiroshi Kiyono, Antonio Molinaro, Koichi Fukase
Angewandte Chemie Vol. 133 No. 18 p. 10111-10119 2021/04/26 Research paper (scientific journal)
Publisher: Wiley
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Lipopolysaccharide from Gut‐Associated Lymphoid‐Tissue‐Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A
Atsushi Shimoyama, Flaviana Di Lorenzo, Haruki Yamaura, Keisuke Mizote, Angelo Palmigiano, Molly D. Pither, Immacolata Speciale, Tomoya Uto, Seiji Masui, Luisa Sturiale, Domenico Garozzo, Koji Hosomi, Naoko Shibata, Kazuya Kabayama, Yukari Fujimoto, Alba Silipo, Jun Kunisawa, Hiroshi Kiyono, Antonio Molinaro, Koichi Fukase
Angewandte Chemie International Edition Vol. 60 No. 18 p. 10023-10031 2021/04/26 Research paper (scientific journal)
Publisher: Wiley
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α‐Emitting cancer therapy using 211 At‐AAMT targeting LAT1
Kazuko Kaneda‐Nakashima, ZiJian Zhang, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Tadashi Watabe, Yoshikatsu Kanai, Kazuhiro Ooe, Atsushi Toyoshima, Yoshifumi Shirakami, Takashi Yoshimura, Mitsuhiro Fukuda, Jun Hatazawa, Takashi Nakano, Koichi Fukase, Atsushi Shinohara
Cancer Science 2020/12/05 Research paper (scientific journal)
Publisher: Wiley
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The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation; Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant
Atsushi Shimoyama, Koichi Fukase
Progress in Inflammation Research Vol. 87 p. 1-19 2020/10 Part of collection (book)
Publisher: Springer International Publishing
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Lymphoid Tissue–Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells
Koji Hosomi, Naoko Shibata, Atsushi Shimoyama, Tomoya Uto, Takahiro Nagatake, Yoko Tojima, Tomomi Nishino, Haruko Takeyama, Koichi Fukase, Hiroshi Kiyono, Jun Kunisawa
Frontiers in Microbiology Vol. 11 p. 561005-561005 2020/09/24 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcuspneumoniae-Specific IgA and Th17 Mediated Protective Immunity.
Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Microorganisms Vol. 8 No. 8 p. 1102-1102 2020/07/23 Research paper (scientific journal)
Publisher: MDPI AG
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Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine.
Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Haruki Yamaura, Takahiro Nagatake, Tomomi Nishino, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Vaccines Vol. 8 No. 3 p. 395-395 2020/07/20 Research paper (scientific journal)
Publisher: MDPI AG
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Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity.
Hirotaka Kanoh, Takahiro Nitta, Shinji Go, Kei-Ichiro Inamori, Lucas Veillon, Wataru Nihei, Mayu Fujii, Kazuya Kabayama, Atsushi Shimoyama, Koichi Fukase, Umeharu Ohto, Toshiyuki Shimizu, Taku Watanabe, Hiroki Shindo, Sorama Aoki, Kenichi Sato, Mika Nagasaki, Yutaka Yatomi, Naoko Komura, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Yoshihiro Natori, Yuichi Yoshimura, Asia Zonca, Anna Cattaneo, Marilena Letizia, Maria Ciampa, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Akemi Suzuki, Jin-Ichi Inokuchi
The EMBO journal Vol. 39 No. 12 2020/05/07 Research paper (scientific journal)
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小腸パイエル板組織内共生菌アルカリゲネスと樹状細胞の相互作用
細見 晃司, 柴田 納央子, 下山 敦史, 宇戸 智哉, 長竹 貴広, 東島 陽子, 西野 友美, 竹山 春子, 深瀬 浩一, 清野 宏, 國澤 純
腸内細菌学雑誌 Vol. 34 No. 2 p. 90-90 2020/04
Publisher: (公財)腸内細菌学会
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Middle molecular and conjugation strategies for development of bioactive middle molecules
Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Koichi Fukase
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry Vol. 78 No. 5 p. 527-537 2020 Research paper (scientific journal)
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小腸パイエル板組織内共生細菌アルカリゲネスの免疫機能とアジュバント応用
柴田 納央子, 細見 晃司, 下山 敦史, 王 韻茹, 吉井 健, 深瀬 浩一, 清野 宏, 國澤 純
日本小児栄養消化器肝臓学会雑誌 Vol. 33 No. 2 p. 133-133 2019/12
Publisher: (一社)日本小児栄養消化器肝臓学会
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がん研究における女性研究者(第6回) がん細胞型アミノ酸トランスポーターを標的とした短寿命アルファ線核医学治療薬の開発(Women scientists in cancer research Investigation of novel drug for alpha-emitting nuclear medicine targeting to cancer specific amino acid transporter)
兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 深瀬 浩一, 篠原 厚
日本癌学会総会記事 Vol. 78回 p. SS-3 2019/09
Publisher: 日本癌学会
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Activities of the Consortium for Medicine, Chemistry, and Physics at Osaka University
Kazuya Kabayama, Kazuko Kaneda, Atsushi Shinohara, Yoshifumi Shirakami, Tadashi Watabe, Zijian Zhang, Atsushi Toyoshima, Takashi Yoshimura, Yoshiyuki Manabe, Atsushi Shimoyama, Koichi Fukase
Journal of Medical Imaging and Radiation Sciences Vol. 50 No. 1 p. S40-S40 2019/03 Research paper (scientific journal)
Publisher: Elsevier BV
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Gut Microbial Lipopolysaccharide Interacts with Host Immune System
A. Shimoyama
Trends in Glycoscience and Glycotechnology 2019/03 Research paper (scientific journal)
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Kinetically controlled Fischer glycosidation under fluidic conditions: A new method for preparing furanosides
Seiji Masui, Yoshiyuki Manabe, Kohtaro Hirao, Atsushi Shimoyama, Takahide Fukuyama, Ilhyong Ryu, Koichi Fukase
Synlett Vol. 30 No. 4 p. 397-400 2019/03 Research paper (scientific journal)
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Investigation of novel drug for nuclear medicine targeting to cancer specific amino acid transporter, LAT1
Kaneda Kazuko, Zhang ZiJian, Manabe Yoshiyuki, Shimoyama Atsushi, Kabayama Kazuya, Kanai Yoshikatsu, Fukase Koichi, Shinohara Atsushi
CANCER SCIENCE Vol. 109 p. 606-606 2018/12
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Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex
Luigi Lembo-Fazio, Jean-Marc Billod, Flaviana Di Lorenzo, Ida Paciello, Mateusz Pallach, Sara Vaz-Francisco, Aurora Holgado, Rudi Beyaert, Manuel Fresno, Atsushi Shimoyama, Rosa Lanzetta, Koichi Fukase, Djamel Gully, Eric Giraud, Sonsoles Martin-Santamaria, Maria-Lina Bernardini, Alba Silipo
FRONTIERS IN IMMUNOLOGY Vol. 9 2018/08 Research paper (scientific journal)
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Bradyrhizobium lipopolysaccharide lipid A: antagonistic properties and molecular basis of its binding to the MD-2/TLR4 complex
L. Lembo-Fazio, J.-M. Billod, F. Di Lorenzo, I. Paciello, M. Pallach, S. Vaz Francisco, A. Holgado, R. Beyaert, M. Fresno, A. Shimoyama, K. Fukase, E. Giraud, S. Martín, Santamaría, M.-L. Bernardini, A. Silipo
Frontiers in Immunology 2018/08 Research paper (scientific journal)
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Narrower HOMO-LUMO gap attained by conformational switching through peripheral polyarylation in 1,4,5,8-tetraaza-9,10-anthraquinodimethanes
Takanori Suzuki, Yusuke Ishigaki, Kazuma Sugawara, Yu Umezawa, Ryo Katoono, Atsushi Shimoyama, Yoshiyuki Manabe, Koichi Fukase, Takanori Fukushima
Tetrahedron Vol. 74 No. 18 p. 2239-2244 2018/05/03 Research paper (scientific journal)
Publisher: Elsevier Ltd
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Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity
Naoko Shibata, Jun Kunisawa, Koji Hosomi, Yukari Fujimoto, Keisuke Mizote, Naohiro Kitayama, Atsushi Shimoyama, Hitomi Mimuro, Shintaro Sato, Natsuko Kishishita, Ken J Ishii, Koichi Fukase, Hiroshi Kiyono
Mucosal Immunology Vol. 11 No. 3 p. 693-702 2018/05/01 Research paper (scientific journal)
Publisher: Nature Publishing Group
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Time-lapse monitoring of TLR2 ligand internalization with newly developed fluorescent probes
Yohei Arai, Kouhei Yokoyama, Yuki Kawahara, Qi Feng, Ippei Ohta, Atsushi Shimoyama, Shinsuke Inuki, Koichi Fukase, Kazuya Kabayama, Yukari Fujimoto
Organic and Biomolecular Chemistry Vol. 16 No. 20 p. 3824-3830 2018 Research paper (scientific journal)
Publisher: Royal Society of Chemistry
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Development of chemically synthesized self-adjuvanting vaccines
Atsushi Shimoyama
Trends in Glycoscience and Glycotechnology Vol. 30 No. 173 p. E41-J21 2018
Publisher: Gakushin Publishing Company
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Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease
K. Murata, Y. Motomura, T. Tanaka, S. Kanno, T. Yano, M. Onimaru, A. Shimoyama, H. Nishio, Y. Sakai, M. Oh-Hora, H. Hara, K. Fukase, H. Takada, S. Masuda, S. Ohga, S. Yamasaki, T. Hara
CLINICAL AND EXPERIMENTAL IMMUNOLOGY Vol. 190 No. 1 p. 54-67 2017/10 Research paper (scientific journal)
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Synthesis and Biofunctional Study of Immunomodulative Lipopolysaccharide Partial Structures
Atsushi Shimoyama, Keisuke Mizote, Yukari Fujimoto, Koichi Fukase
Glycoconjugate Journal Vol. 32 2015/07
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分子イメージングによる糖鎖複合体の動態解析
深瀬浩一, 田中克典, 下山敦史
日本分子イメージング学会機関誌 Vol. 8(2) p. 18-25 2015/05
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Effective Synthesis of Oligosaccharide under Microfiuidic Conditions
Koichi Fukase, Atsushi Shimoyama, Yoshiyuki Manabe
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 73 No. 5 p. 452-459 2015/05 Research paper (scientific journal)
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Sugar Synthesis by microfluidic Techniques
Koichi Fukase, Katsunori Tanaka, Yukari Fujimoto, Atsushi Shimoyama, Yoshiyuki Manabe
Glycochemical Synthesis: Strategies and Applications p. 205-219 2015/01/01 Part of collection (book)
Publisher: Wiley Blackwell
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Bioorthogonal Reactions for Biomolecular Functionalization and Imaging
Atsushi Shimoyama
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 72 No. 3 p. 303-304 2014/03 Research paper (scientific journal)
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Access to a novel near-infrared photodynamic therapy through the combined use of 5-aminolevulinic acid and lanthanide nanoparticles
Atsushi Shimoyama, Hiroya Watase, Yu Liu, Shun-Ichiro Ogura, Yuichiro Hagiya, Kiwamu Takahashi, Katsushi Inoue, Tohru Tanaka, Yasutoshi Murayama, Eigo Otsuji, Akihiro Ohkubo, Hideya Yuasa
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY Vol. 10 No. 4 p. 607-614 2013/12 Research paper (scientific journal)
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Sugar-attached upconversion lanthanide nanoparticles: A novel tool for high-throughput lectin assay
Yu Liu, Takuya Kobayashi, Masayuki Iizuka, Tatsumi Tanaka, Izumi Sotokawa, Atsushi Shimoyama, Yasutoshi Murayama, Eigo Otsuji, Shun-ichiro Ogura, Hideya Yuasa
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 21 No. 11 p. 2832-2842 2013/06 Research paper (scientific journal)
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Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses
Yukari Fujimoto, Atsushi Shimoyama, Akinori Saeki, Naohiro Kitayama, Chika Kasamatsu, Hiroko Tsutsui, Koichi Fukase
MOLECULAR BIOSYSTEMS Vol. 9 No. 5 p. 987-996 2013 Research paper (scientific journal)
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Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A
Yukari Fujimoto, Atsushi Shimoyama, Yasuo Suda, Koichi Fukase
CARBOHYDRATE RESEARCH Vol. 356 p. 37-43 2012/07 Research paper (scientific journal)
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Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity
Koichi Fukase, Yukari Fujimoto, Atsushi Shimoyama, Katsunori Tanaka
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 70 No. 2 p. 113-130 2012/02
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Phylogeny of Galactolipid Synthase Homologs Together with their Enzymatic Analyses Revealed a Possible Origin and Divergence Time for Photosynthetic Membrane Biogenesis
Yuichi Yuzawa, Hidenori Nishihara, Tsuyoshi Haraguchi, Shinji Masuda, Mie Shimojima, Atsushi Shimoyama, Hideya Yuasa, Norihiro Okada, Hiroyuki Ohta
DNA RESEARCH Vol. 19 No. 1 p. 91-102 2012/02 Research paper (scientific journal)
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Chemical Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures and their Selective Proinflammatory Responses
Atsushi Shimoyama, Akinori Saeki, Natsuko Tanimura, Hiroko Tsutsui, Kensuke Miyake, Yasuo Suda, Yukari Fujimoto, Koichi Fukase
CHEMISTRY-A EUROPEAN JOURNAL Vol. 17 No. 51 p. 14464-14474 2011/12 Research paper (scientific journal)
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44 Immunoregulatory Parasitic Bacterial Lipopolysaccharide Partial Structures : Integrated Synthesis and Immune Functional Analysis(Oral Presentation)
Shimoyama Atsushi, Saeki Akinori, Kitayama Naohiro, Kasamatsu Chika, Fujimoto Yukari, Fukase Koichi
Symposium on the Chemistry of Natural Products, symposium papers No. 53 p. 259-264 2011/09/02
Publisher: Symposium on the chemistry of natural products
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Stereoselective glycosylation of 3-deoxy-d-manno-2-octulosonic acid with batch and microfluidic methods
Atsushi Shimoyama, Yukari Fujimoto, Koichi Fukase
Synlett No. 16 p. 2359-2362 2011 Research paper (scientific journal)
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気になった論文
下山敦史
FBC Lett. 2010/11
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Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures
Atsushi Shimoyama, Yukari Fujimoto, Masato Iwata, Chika Kasamatsu, Yasuo Suda, Shoichi Kusumoto, Koichi Fukase
GLYCOBIOLOGY Vol. 18 No. 11 p. 1003-1003 2008/11
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Synthesis and Biofunctional Study of Bacterial Glycoconjugates
K. Fukase, Y. Fujimoto, A. Shimoyama, A. Kawasaki, A. R. Pradipta
Proceeding of the International Seminar on Chemistry p. 46-53 2008 Research paper (international conference proceedings)
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Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures
Yukari Fujimoto, Masato Iwata, Noriko Imakita, Atsushi Shimoyama, Yasuo Suda, Shoichi Kusumoto, Koichi Fukase
TETRAHEDRON LETTERS Vol. 48 No. 37 p. 6577-6581 2007/09 Research paper (scientific journal)
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ORGN 980-Synthesis of immunostimulating peptidoglycan fragments recognized by intracellular receptor
Yukari Fujimoto, Akiko Kawasaki, Atsushi Shimoyama, Naohiro Inohara, Koichi Fukase
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 234 p. 113-130 2007/08 Research paper (scientific journal)
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Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism
Yukari Fujimoto, Seiichi Inamura, Akiko Kawasaki, Zenyu Shiokawa, Atsushi Shimoyama, Takashi Hashimoto, Shoichi Kusumoto, Koichi Fukase
JOURNAL OF ENDOTOXIN RESEARCH Vol. 13 No. 3 p. 189-196 2007 Research paper (scientific journal)
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Synthesis of Fluorescent Probe for Intracellular Innate Immune Receptor Nod1
A. Shimoyama, A. Kawasaki, N. Inohara, Y. Fujimoto, K. Fukase
PEPTIDE SCIENCE 2006/11 Research paper (scientific journal)
