細胞外小胞のプロテオミクスによる肺非結核性抗酸菌症と肺結核の鑑別を可能とする新規バイオマーカー探索

内藤 真依子, 武田 吉人, 枝廣 龍哉, 白井 雄也, 森 雅秀, 矢野 幸洋, 高田 創, 益弘 健太朗, 内藤 祐二朗, 白山 敬之, 三宅 浩太郎, 平田 陽彦, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 13　No. 増刊　p. 166-166　2024/03

TSC-LAMにおける呼吸機能の経時的変化

樋口 貴俊, 平田 陽彦, 高田 創, 内藤 真依子, 益弘 健太朗, 内藤 祐二朗, 白山 敬之, 三宅 浩太郎, 武田 吉人, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 13　No. 増刊　p. 319-319　2024/03

肺移植を検討した造血幹細胞移植後閉塞性細気管支炎症候群の予後 後方視的研究

橋本 和樹, 平田 陽彦, 高田 創, 内藤 真依子, 益弘 健太朗, 内藤 祐二朗, 白山 敬之, 三宅 浩太郎, 武田 吉人, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 13　No. 増刊　p. 344-344　2024/03

Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.

Takashi Hirai, Yujiro Naito, Shohei Koyama, Yoshimitsu Nakanishi, Kentaro Masuhiro, Mayuko Izumi, Tomoki Kuge, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Sujin Kang, Moto Yaga, Yu Futami, Satoshi Nojima, Masayuki Nishide, Takayoshi Morita, Yasuhiro Kato, Takeshi Tsuda, Norihiko Takemoto, Yumi Kinugasa-Katayama, Taiki Aoshi, Jordan Kelly Villa, Kazuo Yamashita, Tomohiro Enokida, Yuta Hoshi, Kazuto Matsuura, Makoto Tahara, Hyota Takamatsu, Yoshito Takeda, Hidenori Inohara, Atsushi Kumanogoh

JCI insight　Vol. 9　No. 3　2024/02/08　Research paper (scientific journal)

Cancer-associated SNRPD3 mutation confers resistance to hypoxia, which is attenuated by DRP1 inhibition.

Shingo Satoh, Kotaro Miyake, Yuichi Adachi, Kentaro Masuhiro, Shinji Futami, Yujiro Naito, Takayuki Shiroyama, Shohei Koyama, Yuta Yamaguchi, Hachiro Konaka, Hyota Takamatsu, Daisuke Okuzaki, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh

Biochemical and biophysical research communications　Vol. 696　p. 149511-149511　2024/01/10　Research paper (scientific journal)

Balloon Dilatation for Bronchoscope Delivery in a Swine Model: A Novel Technique for Ultra-Peripheral Lung Field Access and Accurate Biopsy.

Kotaro Miyake, Takayuki Shiroyama, Shingo Satoh, Yuichi Adachi, Kika Ohira, Yuko Abe, So Takata, Kentaro Masuhiro, Yujiro Naito, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh

Respiration; international review of thoracic diseases　Vol. 103　No. 4　p. 205-213　2024　Research paper (scientific journal)

EGFR遺伝子変異陽性肺癌患者におけるミノサイクリン内服の予後への影響

刀祢 麻里, 岩堀 幸太, 白井 雄也, 高田 創, 益弘 健太朗, 内藤 真依子, 内藤 祐二朗, 福島 清春, 白山 敬之, 三宅 浩太郎, 小山 正平, 平田 陽彦, 長友 泉, 武田 吉人, 和田 尚, 熊ノ郷 淳

肺癌　Vol. 63　No. 5　p. 600-600　2023/10

EGFR遺伝子変異陽性肺癌患者におけるミノサイクリン内服の予後への影響

刀祢 麻里, 岩堀 幸太, 白井 雄也, 高田 創, 益弘 健太朗, 内藤 真依子, 内藤 祐二朗, 福島 清春, 白山 敬之, 三宅 浩太郎, 小山 正平, 平田 陽彦, 長友 泉, 武田 吉人, 和田 尚, 熊ノ郷 淳

肺癌　Vol. 63　No. 5　p. 600-600　2023/10

Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity

Yuichi Mitsui, Tatsuya Suzuki, Kanako Kuniyoshi, Jun Inamo, Kensuke Yamaguchi, Mariko Komuro, Junya Watanabe, Mio Edamoto, Songling Li, Tsukasa Kouno, Seiya Oba, Tadashi Hosoya, Kentaro Masuhiro, Yujiro Naito, Shohei Koyama, Nobuo Sakaguchi, Daron M. Standley, Jay W. Shin, Shizuo Akira, Shinsuke Yasuda, Yasunari Miyazaki, Yuta Kochi, Atsushi Kumanogoh, Toru Okamoto, Takashi Satoh

Immunity　2023/07　Research paper (scientific journal)

Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation.

Yujiro Naito, Shohei Koyama, Kentaro Masuhiro, Takashi Hirai, Takeshi Uenami, Takako Inoue, Akio Osa, Hirotomo Machiyama, Go Watanabe, Nicolas Sax, Jordan Villa, Yumi Kinugasa-Katayama, Satoshi Nojima, Moto Yaga, Yuki Hosono, Daisuke Okuzaki, Shingo Satoh, Takeshi Tsuda, Yoshimitsu Nakanishi, Yasuhiko Suga, Takayoshi Morita, Kiyoharu Fukushima, Masayuki Nishide, Takayuki Shiroyama, Kotaro Miyake, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Yukihiro Yano, Motohiro Tamiya, Toru Kumagai, Norihiko Takemoto, Hidenori Inohara, Sho Yamasaki, Kazuo Yamashita, Taiki Aoshi, Esra A Akbay, Naoki Hosen, Yasushi Shintani, Hyota Takamatsu, Masahide Mori, Yoshito Takeda, Atsushi Kumanogoh

Science advances　Vol. 9　No. 20　2023/05/19　Research paper (scientific journal)

頭頸部癌モデルマウスを用いた腫瘍微小環境の解析

平井 崇士, 久下 朋輝, 益弘 健太朗, 内藤 祐二朗, 小山 正平, 熊ノ郷 淳, 猪原 秀典

頭頸部癌　Vol. 49　No. 2　p. 207-207　2023/05

Identifying phenotypes in interstitial lung disease using group-based trajectory modelling.

S Takata, S Komukai, T Hoshino, H Tabuchi, K Masuhiro, M Yaga, Y Shirai, Y Mitsui, Y Abe, T Kuge, K Fukushima, H Kida, A Kumanogoh

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease　Vol. 27　No. 4　p. 332-334　2023/04/01　Research paper (scientific journal)

Cerebral Infarction Caused by Trousseau's Syndrome Associated With Lung Cancer.

Shoko Ikuta, Kanako Nishimatsu, Nao Shoshihara, Kentaro Masuhiro, Seigo Minami

World journal of oncology　Vol. 13　No. 6　p. 403-408　2022/12　Research paper (scientific journal)

Proposal of a novel pipeline involving precise bronchoscopy of distal peripheral pulmonary lesions for genetic testing.

So Takata, Kotaro Miyake, Daichi Maeda, Kazue Hatake, Izumi Nagatomo, Takayuki Shiroyama, Kentaro Masuhiro, Moto Yaga, Yuya Shirai, Yuichi Mitsui, Shinichi Yachida, Atsushi Kumanogoh

Scientific reports　Vol. 12　No. 1　p. 19774-19774　2022/11/17　Research paper (scientific journal)

Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer.

Yoshimi Noda, Takayuki Shiroyama, Kentaro Masuhiro, Saori Amiya, Takatoshi Enomoto, Yuichi Adachi, Reina Hara, Takayuki Niitsu, Yujiro Naito, Kotaro Miyake, Shohei Koyama, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh

Scientific reports　Vol. 12　No. 1　p. 8881-8881　2022/05/25　Research paper (scientific journal)

Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.

Kentaro Masuhiro, Motohiro Tamiya, Kosuke Fujimoto, Shohei Koyama, Yujiro Naito, Akio Osa, Takashi Hirai, Hidekazu Suzuki, Norio Okamoto, Takayuki Shiroyama, Kazumi Nishino, Yuichi Adachi, Takuro Nii, Yumi Kinugasa-Katayama, Akiko Kajihara, Takayoshi Morita, Seiya Imoto, Satoshi Uematsu, Takuma Irie, Daisuke Okuzaki, Taiki Aoshi, Yoshito Takeda, Toru Kumagai, Tomonori Hirashima, Atsushi Kumanogoh

JCI insight　Vol. 7　No. 9　2022/05/09　Research paper (scientific journal)

微小生検検体の厚切りと薄切枚数増加によるOncomineTM Target Testの実現

高田 創, 三宅 浩太郎, 白井 雄也, 光井 雄一, 益弘 健太朗, 矢賀 元, 白山 敬之, 小山 正平, 岩堀 幸太, 平田 陽彦, 長友 泉, 武田 吉人

気管支学　Vol. 44　No. Suppl.　p. S270-S270　2022/05

Leucine-rich a-2 glycoprotein as a potential biomarker of idiopathic multicentric Castleman disease with pulmonary involvement: a single-center case-control study from Japan.

So Takata, Yoshito Takeda, Haruhiko Hirata, Yuya Shirai, Takayoshi Morita, Yu Futami, Yujiro Naito, Kentaro Masuhiro, Takayuki Shiroyama, Kotaro Miyake, Tetsuji Naka, Atsushi Kumanogoh

Journal of thoracic disease　Vol. 14　No. 5　p. 1332-1341　2022/05　Research paper (scientific journal)

免疫チェックポイント阻害薬 気管支肺胞洗浄液を用いた肺癌免疫微小環境の解析による抗PD-1抗体効果予測因子の探索

益弘 健太朗, 田宮 基裕, 藤本 康介, 内藤 祐二朗, 小山 正平, 白山 敬之, 井上 貴子, 西野 和美, 鈴木 秀和, 岡本 紀雄, 平島 智徳, 熊谷 融, 武田 吉人, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 11　No. 増刊　p. 156-156　2022/04

セマフォリン4A(Sema4A)はがん微小環境において抗原特異的CD8陽性T細胞の活性化を促進する

内藤 祐二朗, 益弘 健太朗, 平井 崇士, 山下 和男, 青枝 大貴, 小山 正平, 武田 吉人, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 11　No. 増刊　p. 263-263　2022/04

胸部腫瘍 ペムブロリズマブを一次治療で導入した非小細胞肺癌症例における単剤または化学療法併用の末梢血免疫プロファイルに与える影響の検討

益弘 健太朗, 内藤 祐二朗, 小山 正平, 上浪 健, 仲谷 健史, 白山 敬之, 三宅 浩太郎, 岩堀 幸太, 平田 陽彦, 金津 正樹, 赤澤 結貴, 矢野 幸洋, 森 雅秀, 長友 泉, 武田 吉人, 熊ノ郷 淳

日本呼吸器学会誌　Vol. 9　No. 増刊　p. 131-131　2020/08

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood.

Yujiro Naito, Akio Osa, Kentaro Masuhiro, Takashi Hirai, Shohei Koyama, Atsushi Kumanogoh

Journal of visualized experiments : JoVE　No. 156　2020/02/05　Research paper (scientific journal)

抗PD-1抗体結合モニタリングを用いた肺癌治療・有害事象の臨床経過の検討

内藤 祐二朗, 上浪 健, 益弘 健太朗, 長 彰翁, 小山 正平, 矢野 幸洋, 中坪 彩恵子, 赤澤 結貴, 金津 正樹, 石島 見佳子, 白山 敬之, 平田 陽彦, 長友 泉, 武田 吉人, 木田 博, 森 雅秀, 熊ノ郷 淳

肺癌　Vol. 59　No. 6　p. 909-909　2019/11

EGFR遺伝子変異検査において、測定法により異なる結果となった1例

高田 創, 長友 泉, 白井 雄也, 光井 雄一, 益弘 健太朗, 矢賀 元, 白山 敬之, 三宅 浩太郎, 小山 正平, 岩堀 幸太, 平田 陽彦, 武田 吉人, 木田 博, 熊ノ郷 淳

肺癌　Vol. 59　No. 4　p. 418-419　2019/08

Unique Case of Pseudoprogression Manifesting as Lung Cavitation After Pembrolizumab Treatment.

Kentaro Masuhiro, Takayuki Shiroyama, Izumi Nagatomo, Atsushi Kumanogoh

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer　Vol. 14　No. 5　2019/05

非小細胞肺癌に対してペムブロリズマブを導入し、空洞影が新規に出現した1例

益弘 健太朗, 白井 雄也, 光井 雄一, 高田 創, 矢賀 元, 福島 清春, 白山 敬之, 三宅 浩太郎, 小山 正平, 平田 陽彦, 長友 泉, 武田 吉人, 木田 博, 熊之郷 淳

肺癌　Vol. 59　No. 2　p. 206-207　2019/04

Impact of sarcopenia in patients with advanced non-small cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study.

Takayuki Shiroyama, Izumi Nagatomo, Shohei Koyama, Haruhiko Hirata, Sumiyuki Nishida, Kotaro Miyake, Kiyoharu Fukushima, Yuya Shirai, Yuichi Mitsui, So Takata, Kentaro Masuhiro, Moto Yaga, Kota Iwahori, Yoshito Takeda, Hiroshi Kida, Atsushi Kumanogoh

Scientific reports　Vol. 9　No. 1　p. 2447-2447　2019/02/21　Research paper (scientific journal)

A case of successful concurrent anti-cancer treatment in a patient who developed follicular lymphoma during treatment with afatinib for advanced lung adenocarcinoma.

Kentaro Masuhiro, Genju Koh, So Takata, Shingo Nasu, Hiromune Takada, Satomu Morita, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Hiromi Kawasumi, Chihiro Konishi, Tomonori Hirashima

Respiratory medicine case reports　Vol. 28　p. 100862-100862　2019

Osimertinib Treatment Was Unsuccessful for Lung Adenocarcinoma with G719S, S768I, and T790M Mutations.

Shingo Nasu, Takayuki Shiroyama, Satomu Morita, So Takata, Hiromune Takada, Kentaro Masuhiro, Ayako Tanaka, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Tomonori Hirashima

Internal medicine (Tokyo, Japan)　Vol. 57　No. 24　p. 3643-3645　2018/12/15　Research paper (scientific journal)

Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer.

Taro Koba, Seigo Minami, Yu Nishijima-Futami, Kentaro Masuhiro, Hiromi Kimura, Shinji Futami, Moto Yaga, Masahide Mori, Hiroyuki Kagawa, Takeshi Uenami, Satoshi Kohmo, Tomoyuki Otsuka, Suguru Yamamoto, Kiyoshi Komuta, Takashi Kijima

Cancer chemotherapy and pharmacology　Vol. 82　No. 1　p. 111-117　2018/07　Research paper (scientific journal)

Impact of Pleural Effusion on Outcomes of Patients Receiving Osimertinib for NSCLC Harboring EGFR T790M.

Kentaro Masuhiro, Takayuki Shiroyama, Hidekazu Suzuki, S O Takata, Shingo Nasu, Hiromune Takada, Satomu Morita, Ayako Tanaka, Naoko Morishita, Norio Okamoto, Tomonori Hirashima

Anticancer research　Vol. 38　No. 6　p. 3567-3571　2018/06　Research paper (scientific journal)

Skin Rash Can Be a Useful Marker for Afatinib Efficacy.

Shingo Nasu, Hidekazu Suzuki, Takayuki Shiroyama, Ayako Tanaka, Kaori Iwata, Noriko Ryota, Yuki Ueda, S O Takata, Kentaro Masuhiro, Satomu Morita, Naoko Morishita, Norio Okamoto, Tomonori Hirashima

Anticancer research　Vol. 38　No. 3　p. 1783-1788　2018/03　Research paper (scientific journal)

Transformation to small cell lung cancer after first-line afatinib treatment.

Takayuki Shiroyama, Shingo Nasu, Ayako Tanaka, So Takata, Kentaro Masuhiro, Hiromune Takada, Satomu Morita, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Kunimitsu Kawahara, Tomonori Hirashima

Respiratory medicine case reports　Vol. 23　p. 188-190　2018

CLINICAL ANALYSIS OF AFATINIB IN EGFR-TYROSINE KINASE INHIBITOR NAIVE PATIENTS WITH NON-SMALL CELL LUNG CANCER HABORING EGFR MUTATIONS

Nasu Shingo, Takata So, Masuhiro Kentaro, Morita Satomu, Iwata Kaori, Ryota Noriko, Okada Yukari, Tokuoka Yoshie, Ueda Yuki, Kumode Akinori, Usui Naoko, Tanaka Ayako, Shiroyama Takayuki, Morishita Naoko, Suzuki Hidekazu, Okamoto Norio, Hirashima Tomonori

RESPIROLOGY　Vol. 22　2017/11

Carboplatin plus weekly nanoparticle albumin-bound paclitaxel in elderly patients with previously untreated advanced squamous non-small-cell lung cancer selected based on Mini Nutritional Assessment short-form scores: a multicenter phase 2 study.

Takayuki Shiroyama, Motohiro Tamiya, Seigo Minami, So Takata, Kentaro Masuhiro, Yu Futami-Nishijima, Takeshi Uenami, Masahide Mori, Taro Koba, Takanori Matsuki, Takayuki Takimoto, Hidekazu Suzuki, Norio Okamoto, Kiyoshi Komuta, Tomonori Hirashima, Atsushi Kumanogoh, Takashi Kijima

Cancer chemotherapy and pharmacology　Vol. 80　No. 3　p. 461-467　2017/09　Research paper (scientific journal)

Small-cell lung cancer: a case report on the manifestation of paraneoplastic motor neuron disease after effective tumor shrinkage during chemotherapy

Seigo Minami, Tomoko Okazaki, Masanari Hamaguchi, Shyouichi Shiraishi, Suguru Yamamoto, Yoshitaka Ogata, Taro Koba, Shinji Futami, Yu Nishijima, Moto Yaga, Kentaro Masuhiro, Kiyoshi Komuta

Metallography, Microstructure, and Analysis　Vol. 3　No. 4　p. 247-251　2014/10/01　Research paper (scientific journal)

Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital.

Kosuke Fujimoto, Seigo Minami, Suguru Yamamoto, Yoshitaka Ogata, Taro Koba, Shinji Futami, Yuh Nishijima, Moto Yaga, Kentaro Masuhiro, Kiyoshi Komuta

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer　Vol. 22　No. 6　p. 1485-92　2014/06　Research paper (scientific journal)

Amylase-Producing Lung Cancer with a Positive Epidermal Growth Factor Receptor Mutation Treated With Gefitinib: A Case Report.

Seigo Minami, Ryu Jokoji, Suguru Yamamoto, Yoshitaka Ogata, Taro Koba, Shinji Futami, Yu Nishijima, Moto Yaga, Kentaro Masuhiro, Masahiko Tsujimoto, Kiyoshi Komuta

World journal of oncology　Vol. 5　No. 1　p. 41-46　2014/02