日本薬理学
日本免疫学会
日本アンドロロジー学会
日本癌学会
Life sciences / Tumor diagnostics and therapeutics /
Life sciences / Urology /
Life sciences / Pharmacology /
日本アンドロロジー学会学術奨励賞
2017/06
Structural basis of anticancer drug recognition and amino acid transport by LAT1
Yongchan Lee, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Satoshi Ogasawara, Rangana Warshamanage, Keitaro Yamashita, Garib Murshudov, Osamu Nureki, Takeshi Murata, Yoshikatsu Kanai
Nature Communications Vol. 16 No. 1 2025/02/14 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy
Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai
Scientific Reports Vol. 15 No. 1 2025/01/23 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia.
Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai
Scientific reports Vol. 14 No. 1 p. 19635-19635 2024/08/23 Research paper (scientific journal)
Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells
Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai
Journal of Pharmacological Sciences Vol. 155 No. 1 p. 14-20 2024/05 Research paper (scientific journal)
Publisher: Elsevier BV
The LAT1 inhibitor JPH203 suppresses the growth of castration-resistant prostate cancer through a CD24-mediated mechanism.
Shinpei Saito, Keisuke Ando, Shinichi Sakamoto, Minhui Xu, Yasutaka Yamada, Junryo Rii, Sanji Kanaoka, Jiaxing Wei, Xue Zhao, Sangjon Pae, Manato Kanesaka, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura, Yoshie Reien, Norie Hamaguchi-Suzuki, Shota Saito, Yuri Hirayama, Hirofumi Hashimoto, Yoshikatsu Kanai, Tomohiko Ichikawa, Naohiko Anzai
Cancer science 2024/04/24 Research paper (scientific journal)
Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation
Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai
Journal of Pharmacological Sciences Vol. 154 No. 3 p. 182-191 2024/03 Research paper (scientific journal)
Publisher: Elsevier BV
Structure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)
Sihui Chen, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai
Scientific Reports Vol. 14 No. 1 2024/02/26 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells
Xingming Liu, Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Yoshikatsu Kanai
Journal of Pharmacological Sciences 2024/02 Research paper (scientific journal)
Publisher: Elsevier BV
L-type amino acid transporter 1 inhibitor JPH203 prevents the growth of cabazitaxel-resistant prostate cancer by inhibiting cyclin-dependent kinase activity.
Junryo Rii, Shinichi Sakamoto, Atsushi Mizokami, Minhui Xu, Ayumi Fujimoto, Shinpei Saito, Hidekazu Koike, Takaaki Tamura, Takayuki Arai, Yasutaka Yamada, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura, Kazuhiro Suzuki, Yoshikatsu Kanai, Naohiko Anzai, Tomohiko Ichikawa
Cancer science 2024/01/07 Research paper (scientific journal)
Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models.
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Scientific Reports Vol. 13 No. 1 p. 13943-13943 2023/08/25 Research paper (scientific journal)
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells
Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Cancer Cell International Vol. 23 No. 1 2023/06/15 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1
Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Cancer & Metabolism Vol. 10 No. 1 2022/11/10 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Pharmacologic inhibition of <scp>LAT1</scp> predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells
Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Journal of Cellular and Molecular Medicine 2022/09/07 Research paper (scientific journal)
Publisher: Wiley
Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10
Naoko Ohtsu, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Ryo Takahashi, Akiko Matsui, Wataru Kishimoto, Naoki Ishiguro, Yoshikatsu Kanai
Journal of Pharmacological Sciences Vol. 150 No. 1 p. 41-48 2022/09 Research paper (scientific journal)
Publisher: Elsevier BV
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2
Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki
Nature Communications Vol. 13 No. 1 2022/08/11 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2.
Maihulan Maimaiti, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumi Fujimoto, Keisuke Matsusaka, Minhui Xu, Keisuke Ando, Shinpei Saito, Ken Wakai, Yusuke Imamura, Keiichi Nakayama, Yoshikatsu Kanai, Atsushi Kaneda, Yuzuru Ikehara, Jun-Ichiro Ikeda, Naohiko Anzai, Tomohiko Ichikawa
Scientific reports Vol. 11 No. 1 p. 11478-11478 2021/06/01 Research paper (scientific journal)
Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.
Junryo Rii, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumu Fujimoto, Yasutaka Yamada, Maihulan Maimaiti, Keisuke Ando, Ken Wakai, Minhui Xu, Yusuke Imamura, Norihisa Shindo, Toru Hirota, Atsushi Kaneda, Yoshikatsu Kanai, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa
Cancer science Vol. 112 No. 9 p. 3871-3883 2021/05/29 Research paper (scientific journal)
Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes.
Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Minhui Xu, Suguru Okuda, Hiroki Okanishi, Yasuharu Kawamoto, Xin He, Shushi Nagamori, Yoshikatsu Kanai
The Journal of pharmacology and experimental therapeutics Vol. 375 No. 3 p. 451-462 2020/12 Research paper (scientific journal)
Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma.
Maihulan Maimaiti, Shinichi Sakamoto, Yasutaka Yamada, Masahiro Sugiura, Junryo Rii, Nobuyoshi Takeuchi, Yusuke Imamura, Tomomi Furihata, Keisuke Ando, Kosuke Higuchi, Minhui Xu, Tomokazu Sazuka, Kazuyoshi Nakamura, Atsushi Kaneda, Yoshikatsu Kanai, Natasha Kyprianou, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa
Scientific reports Vol. 10 No. 1 p. 1292-1292 2020/01/28 Research paper (scientific journal)
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated Castration-Resistant Prostate Cancer.
Shinichi Sakamoto, Maihulan Maimaiti, Minhui Xu, Shuhei Kamada, Yasutaka Yamada, Hiroki Kitoh, Hiroaki Matsumoto, Nobuyoshi Takeuchi, Kosuke Higuchi, Haruhito A Uchida, Akira Komiya, Maki Nagata, Hiroomi Nakatsu, Hideyasu Matsuyama, Koichiro Akakura, Tomohiko Ichikawa
Journal of clinical medicine Vol. 8 No. 4 2019/04/11 Research paper (scientific journal)
Duration of androgen deprivation therapy and nadir of testosterone at 20 ng/dL predict testosterone recovery to supracastrate level in prostate cancer patients who received external beam radiotherapy.
Akinori Takei, Shinichi Sakamoto, Ken Wakai, Takaaki Tamura, Yusuke Imamura, Minhui Xu, Maihulan Maimaiti, Koji Kawamura, Takashi Imamoto, Akira Komiya, Koichiro Akakura, Tomohiko Ichikawa
International journal of urology : official journal of the Japanese Urological Association Vol. 25 No. 4 p. 352-358 2018/04 Research paper (scientific journal)
Testosterone Reduction of ≥ 480 ng/dL Predicts Favorable Prognosis of Japanese Men With Advanced Prostate Cancer Treated With Androgen-Deprivation Therapy.
Satoshi Yamamoto, Shinichi Sakamoto, Xu Minhui, Takaaki Tamura, Kotaro Otsuka, Kodai Sato, Marghulan Maimaiti, Shuhei Kamada, Akinori Takei, Miki Fuse, Kouji Kawamura, Takashi Imamoto, Akira Komiya, Koichiro Akakura, Tomohiko Ichikawa
Clinical genitourinary cancer Vol. 15 No. 6 2017/12 Research paper (scientific journal)
Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells.
Minhui Xu, Shinichi Sakamoto, Jun Matsushima, Toru Kimura, Takeshi Ueda, Atsushi Mizokami, Yoshikatsu Kanai, Tomohiko Ichikawa
The Journal of urology Vol. 195 No. 5 p. 1588-1597 2016/05 Research paper (scientific journal)
Enhancing Anti-tumor Effect of PD-1 Inhibitors through T-Cell Activation by Amino Acid Transporter LAT1 Inhibitor
徐旻恵, 周新宇, 金春奐, 岡西広樹, 大垣隆一, 遠藤仁, 金井好克
日本癌学会学術総会抄録集(Web) Vol. 82nd 2023
L-type amino acid transporter 1 inhibitor JPH203 as a new therapeutic target for castration resistant prostate cancer
坂本信一, 齋藤心平, 齋藤心平, 安藤敬介, 安藤敬介, 梨井隼菱, 徐旻恵, 金井好克, 安西尚彦, 市川智彦
日本癌学会学術総会抄録集(Web) Vol. 81回 p. E-3078 2022/09
Contribution of LAT1 to amino acid uptake in cancer cells and suppression of cellular protein synthesis by LAT1 inhibitor
Nishikubo Kou, Ohgaki Ryuichi, Okanishi Hiroki, Okuda Suguru, Xu Minhui, Endou Hitoshi, Kanai Yoshikatsu
Proceedings for Annual Meeting of The Japanese Pharmacological Society Vol. 95 2022
Publisher: Japanese Pharmacological Society
高齢者における新規アンドロゲン受容体阻害剤の予後予測因子の検討
坂本信一, 竹内信善, XU Minhui, 鎌田修平, 山田康隆, 木藤宏樹, 松本洋明, 松山豪泰, 小宮顕, 赤倉功一郎, 市川智彦
日本アンドロロジー学会総会記事 Vol. 36th 2017
Up-regulation of LAT1 during androgen deprivation therapy contributes to acquisition of castration resistance in prostate cancer cells
SAKAMOTO Shinichi, XU Minhui, MAIMAITI Marghulan, KANAI Yoshikatsu, ANZAI Naohiko, ICHIKAWA Tomohiko
がんと代謝研究会プログラム&抄録集 Vol. 5th 2017
新規前立腺癌去勢抵抗性のメカニズムとしてのLAT1の役割
坂本信一, XU Minhui, 木村徹, 五島悠介, 布施美樹, 川村幸治, 今本敬, 安西尚彦, 金井好克, 関直彦, 市川智彦
日本がん分子標的治療学会学術集会プログラム・抄録集 Vol. 20th 2016
前立腺がん進展の分子メカニズムと去勢抵抗性前立腺がんに対する治療戦略 ARを介した前立腺癌進展のメカニズム
坂本 信一, 徐 旻恵, 黒住 顕, 加藤 繭子, 五島 悠介, 西川 里佳, 関 直彦, 市川 智彦
日本癌学会総会記事 Vol. 74回 p. SST8-3 2015/10
Publisher: (一社)日本癌学会
Androgen Receptor negatively regulate aminoacid transporter LAT1 in prostate cancer.
SAKAMOTO Shinichi, JYO Binkei, KUROSUMI Akira, KATO Mayuko, GOTO Yusuke, NISHIKAWA Rika, FUSE Miki, KAWAMURA Koji, IMAMOTO Takashi, NIHEI Naoki, ICHIKAWA Tomohiko
日本泌尿器科学会総会プログラム抄録集(CD-ROM) Vol. 103rd 2015
去勢抵抗性前立腺癌の増殖におけるLAT1の役割
徐旻恵, 坂本信一, 五島悠介, 西川里佳, 川村幸治, 今本敬, 二瓶直樹, 永森收志, 金井好克, 市川智彦
日本アンドロロジー学会総会記事 Vol. 33rd 2014
腎細胞癌におけるLAT1/4F2hcの発現と予後との関連(Upregulation of LAT1/4F2hc correlated with prognosis in Renal Cell Carcinoma)
坂本 信一, Ahmed Nasar, 徐 旻恵, 巣山 貴仁, 内海 孝信, 二瓶 直樹, 遠藤 仁, 金井 好克, 市川 智彦
日本癌学会総会記事 Vol. 72回 p. 435-435 2013/10
Publisher: (一社)日本癌学会