Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs.

Fumihiro Fujiki, Soyoko Morimoto, Yuya Nishida, Satoe Tanii, Nao Aoyama, Miki Inatome, Kento Inoue, Akiko Katsuhara, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 72　No. 7　p. 2347-2356　2023/03/20　Research paper (scientific journal)

Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia.

Hikaru Minagawa, Yoshiko Hashii, Hiroko Nakajima, Fumihiro Fujiki, Soyoko Morimoto, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Akihiro Tsuboi, Keiichi Ozono

BMC cancer　Vol. 23　No. 1　p. 167-167　2023/02/20　Research paper (scientific journal)

WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1

Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, Motoyuki Suzuki, Sumiyuki Nishida, Jun Nakata, Akihiro Tsuboi, Miki Iwai, Sae Hayashi, Rin Imanishi, Sayaka Ikejima, Mizuki Kanegae, Masahiro Iwamoto, Mayu Ikeda, Kento Yagi, Haruka Shimokado, Hiroko Nakajima, Kana Hasegawa, Soyoko Morimoto, Fumihiro Fujiki, Akira Nagahara, Atsushi Tanemura, Yutaka Ueda, Tsunekazu Mizushima, Masato Ohmi, Takayuki Ishida, Manabu Fujimoto, Norio Nonomura, Tadashi Kimura, Hidenori Inohara, Seiji Okada, Haruhiko Kishima, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Haruo Sugiyama

Cancers　Vol. 15　No. 2　p. 393-393　2023/01/06　Research paper (scientific journal)

GEM併用WT1ワクチン投与膵癌患者からのWT1^126特異的high-avidity TCRの単離

森本 創世子, 藤木 文博, 西田 純幸, 永田 暁教, 中田 潤, 中島 博子, 尾路 祐介, 岡 芳弘, 杉山 治夫

日本臨床免疫学会総会プログラム・抄録集　Vol. 50回　p. 112-112　2022/10　Research paper (conference, symposium, etc.)

An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia.

Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Kiyoshi Takeda, Akihiro Tsuboi, Keiichi Ozono

Cancer immunology, immunotherapy : CII　Vol. 72　No. 1　p. 39-53　2022/06/14　Research paper (scientific journal)

WT1蛋白を標的とした小児固形腫瘍に対するがん免疫療法 予後と免疫学的解析

橋井 佳子, 細谷 要介, 岡 芳弘, 尾路 祐介, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 鐘ヶ江 瑞稀, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 26回　p. 140-140　2022/06　Research paper (conference, symposium, etc.)

Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Akie Iehara, Mai Iwai, Seishin Hashiguchi, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Satoshi Yoshihara, Masahiro Manabe, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Takafumi Nakao, Asao Hirose, Masayuki Hino, Shiho Ueda, Katsuto Takenaka, Takashi Masuko, Koichi Akashi, Takahiro Maruno, Susumu Uchiyama, Shinji Takamatsu, Naoki Wada, Eiichi Morii, Shushi Nagamori, Daisuke Motooka, Yoshikatsu Kanai, Yusuke Oji, Tomoyoshi Nakagawa, Noriyuki Kijima, Haruhiko Kishima, Atsuyo Ikeda, Takayuki Ogino, Yasushi Shintani, Tateki Kubo, Emiko Mihara, Kosuke Yusa, Haruo Sugiyama, Junichi Takagi, Eiji Miyoshi, Atsushi Kumanogoh, Naoki Hosen

Science translational medicine　Vol. 14　No. 632　2022/02/16　Research paper (scientific journal)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine.

Shouq Alzaaqi, Norifumi Naka, Kenichiro Hamada, Naoki Hosen, Mizuki Kanegae, Hidetatsu Outani, Mayuko Adachi, Rin Imanishi, Eiichi Morii, Miki Iwai, Jun Nakata, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Oncology letters　Vol. 23　No. 2　p. 65-65　2022/02　Research paper (scientific journal)

T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy.

Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Frontiers in immunology　Vol. 13　p. 935465-935465　2022　Research paper (scientific journal)

Cellular and Humoral Immune Responses Induced by an HLA Class I–restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer

Sumiyuki Nishida, Soyoko Morimoto, Yusuke Oji, Satoshi Morita, Toshiaki Shirakata, Takayuki Enomoto, Akihiro Tsuboi, Yutaka Ueda, Kiyoshi Yoshino, Alzaaqi Shouq, Mizuki Kanegae, Satoshi Ohno, Fumihiro Fujiki, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Tadashi Kimura, Haruo Sugiyama

Journal of Immunotherapy　Vol. 45　No. 1　p. 56-66　2022/01　Research paper (scientific journal)

難治性白血病に対する同種造血幹細胞移植後WT1ペプチドワクチン接種時の免疫応答の解析(WT1-targeteing immunotherapy after allogeneic HSCT in children with refractory acute leukemias)

橋井 佳子, 岡 芳弘, 坂田 尚己, 渡辺 新, 尾路 祐介, 保仙 直毅, 山本 紘司, 服部 聡, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 池島 彩香, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本血液学会学術集会　Vol. 83回　p. OS1-5　2021/09

Identification of mouse helper epitopes for WT1-specific CD4+ T cells.

Hiroko Nakajima, Jun Nakata, Kanako Imafuku, Hiromu Hayashibara, Kazuki Isokawa, Keiko Udaka, Fumihiro Fujiki, Soyoko Morimoto, Kana Hasegawa, Naoki Hosen, Yoshiko Hashii, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 11　p. 3323-3335　2021/07/16　Research paper (scientific journal)

WT1ヘルパーペプチド併用WT1ペプチドワクチン投与患者における異なる2つのWT1-tetramer+CD8+T細胞集団の同定

藤木 文博, 坪井 昭博, 森本 創世子, 橋本 直哉, 稲留 美希, 中島 博子, 中田 潤, 西田 純幸, 岡 芳弘, 尾路 祐介, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 25回　p. 175-175　2021/05

Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies

Chisato Yokota, Jun Nakata, Koji Takano, Hiroko Nakajima, Hiromu Hayashibara, Hikaru Minagawa, Yasuyoshi Chiba, Ryuichi Hirayama, Noriyuki Kijima, Manabu Kinoshita, Yoshiko Hashii, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Kagawa, Haruhiko Kishima

Neuro-Oncology Advances　Vol. 3　No. 1　2021/01/01　Research paper (scientific journal)

Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.

Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Kana Hasegawa, Naoki Hosen, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 1　p. 253-263　2021/01　Research paper (scientific journal)

Enhanced immune reaction resulting from co-vaccination of WT1 helper peptide assessed on PET-CT.

Jun Nakata, Kayako Isohashi, Soyoko Morimoto, Ryota Itou, Takashi Kamiya, Ai Matsuura, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Yoshiko Hasii, Kana Hasegawa, Shinichi Nakatsuka, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Atsushi Kumanogoh, Masaru Shibano, Satoru Munakata, Yusuke Oji, Jun Hatazawa, Haruo Sugiyama

Medicine　Vol. 99　No. 39　2020/09/25　Research paper (scientific journal)

マウス神経膠腫モデルにおけるWT1ワクチン療法と抗PD-1抗体療法の併用による抗腫瘍効果の増強

林原 弘武, 横田 千里, 高野 浩司, 中田 潤, 皆川 光, 中島 博子, 橋井 佳子, 尾路 祐介, 坪井 昭博, 岡 芳弘, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 24回　p. 106-106　2020/09

Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy.

Sae Hayashi, Rin Imanishi, Mayuko Adachi, Sayaka Ikejima, Jun Nakata, Soyoko Morimoto, Fumihiro Fujiki, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Hiroko Nakajima, Kana Hasegawa, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Biomedical reports　Vol. 12　No. 5　p. 244-250　2020/05　Research paper (scientific journal)

癌免疫 脳腫瘍患者におけるWT1ヘルパーペプチド併用WT1ペプチドワクチン療法の免疫モニタリング解析

森本 創世子, 藤木 文博, 近藤 健太, 中島 博子, 西田 純幸, 中田 潤, 保仙 直毅, 坪井 昭博, 岡 芳弘, 尾路 祐介, 杉山 治夫

日本臨床免疫学会総会プログラム・抄録集　Vol. 47回　p. 85-85　2019/10

Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.

Sumiyuki Nishida, Akihiro Tsuboi, Atsushi Tanemura, Toshinori Ito, Hiroko Nakajima, Toshiaki Shirakata, Soyoko Morimoto, Fumihiro Fujiki, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Ichiro Kawase, Yoshihiro Oka, Ichiro Azuma, Satoshi Morita, Haruo Sugiyama

Medicine　Vol. 98　No. 33　2019/08　Research paper (scientific journal)

A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma.

Tsuboi A, Hashimoto N, Fujiki F, Morimoto S, Kagawa N, Nakajima H, Hosen N, Nishida S, Nakata J, Morita S, Sakamoto J, Oji Y, Oka Y, Sugiyama H

Cancer immunology, immunotherapy : CII　Vol. 68　No. 2　p. 331-340　2018/11　Research paper (scientific journal)

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.

Nakata J, Nakajima H, Hayashibara H, Imafuku K, Morimoto S, Fujiki F, Motooka D, Okuzaki D, Hasegawa K, Hosen N, Tsuboi A, Oka Y, Kumanogoh A, Oji Y, Sugiyama H

Oncotarget　Vol. 9　No. 89　p. 36029-36038　2018/11　Research paper (scientific journal)

Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.

Soyoko Morimoto, Fumihiro Fujiki, Kenta Kondo, Hiroko Nakajima, Yoshiki Kobayashi, Miki Inatome, Nao Aoyama, Yuya Nishida, Akihiro Tsuboi, Yoshihiro Oka, Sumiyuki Nishida, Jun Nakata, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

Oncotarget　Vol. 9　No. 75　p. 34132-34141　2018/09/25　Research paper (scientific journal)

Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.

Jun Nakata, Yoshiki Nakae, Manabu Kawakami, Soyoko Morimoto, Daisuke Motooka, Naoki Hosen, Fumihiro Fujiki, Hiroko Nakajima, Kana Hasegawa, Sumiyuki Nishida, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh, Haruo Sugiyama

British journal of haematology　Vol. 182　No. 2　p. 287-290　2018/07

WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies.

Yusuke Oji, Masayoshi Inoue, Yoshito Takeda, Naoki Hosen, Yasushi Shintani, Manabu Kawakami, Takuya Harada, Yui Murakami, Miki Iwai, Mari Fukuda, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Toshiaki Shirakata, Hiroko Nakajima, Kana Hasegawa, Hiroshi Kida, Takashi Kijima, Soyoko Morimoto, Fumihiro Fujiki, Akihiro Tsuboi, Eiichi Morii, Satoshi Morita, Junichi Sakamoto, Atsushi Kumanogoh, Yoshihiro Oka, Meinoshin Okumura, Haruo Sugiyama

International journal of cancer　Vol. 142　No. 11　p. 2375-2382　2018/06/01　Research paper (scientific journal)

The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy.

Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi, Atsushi Kumanogoh

Nature medicine　Vol. 23　No. 12　p. 1436-1443　2017/12　Research paper (scientific journal)

The activated conformation of integrin beta(7) is a novel multiple myeloma-specific target for CAR T cell therapy

Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi, Atsushi Kumanogoh

NATURE MEDICINE　Vol. 23　No. 12　p. 1436-+　2017/12　Research paper (scientific journal)

A Zbtb7a proto-oncogene as a novel target for miR-125a

Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji

MOLECULAR CARCINOGENESIS　Vol. 55　No. 12　p. 2001-2009　2016/12　Research paper (scientific journal)

Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.

Satoshi Takashima, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Sumiyuki Nishida, Naoki Hosen, Naoya Tatsumi, Kenji Mizuguchi, Naoya Hashimoto, Yusuke Oji, Akihiro Tsuboi, Atsushi Kumanogoh, Haruo Sugiyama

Future science OA　Vol. 2　No. 4　2016/12　Research paper (scientific journal)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide

Yusuke Oji, Naoya Hashimoto, Akihiro Tsuboi, Yui Murakami, Miki Iwai, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Olga Elisseeva, Ryo Ichinohasama, Junichi Sakamoto, Satoshi Morita, Hiroko Nakajima, Satoshi Takashima, Yoshiki Nakae, Jun Nakata, Manabu Kawakami, Sumiyuki Nishida, Naoki Hosen, Fumihiro Fujiki, Soyoko Morimoto, Mayuko Adachi, Masahiro Iwamoto, Yoshihiro Oka, Toshiki Yoshimine, Haruo Sugiyama

INTERNATIONAL JOURNAL OF CANCER　Vol. 139　No. 6　p. 1391-1401　2016/09　Research paper (scientific journal)

Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.

Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, Seya T

Oncoimmunology　Vol. 5　No. 8　2016/08　Research paper (scientific journal)

Co-administration of alpha-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells

Jordana G. Coelho-dos-Reis, Jing Huang, Tiffany Tsao, Felipe V. Pereira, Ryota Funakoshi, Hiroko Nakajima, Haruo Sugiyama, Moriya Tsuji

CLINICAL IMMUNOLOGY　Vol. 168　p. 6-15　2016/07　Research paper (scientific journal)

Induction of eEF2-specific antitumor CTL responses in vivo by vaccination with eEF2-derived 9mer-peptides

Hiroko Nakajima, Yui Murakami, Eiichi Morii, Toshiki Akao, Naoya Tatsumi, Satoko Odajima, Mari Fukuda, Takao Machitani, Miki Iwai, Sayo Kawata, Nozomi Hojo, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

ONCOLOGY REPORTS　Vol. 35　No. 4　p. 1959-1966　2016/04　Research paper (scientific journal)

An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8(+) T Cells

Kenta Kondo, Fumihiro Fujiki, Hiroko Nakajima, Erika Yatsukawa, Soyoko Morimoto, Naoya Tatsumi, Sumiyuki Nishida, Jun Nakata, Yoshihiro Oka, Akihiro Tsuboi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 39　No. 3　p. 127-139　2016/04　Research paper (scientific journal)

Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Katsuhiko Nakano, Hiroko Kinoshita, Atsushi Okumura, Yuka Fujioka, Rika Urakawa, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eiji Miyoshi, Takako Hirata, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

WT1 peptide vaccine for the treatment of malignancies: Its development, recent progress, and future perspectives

Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Soyoko Morimoto, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Naoya Tatsumi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

Immunotherapy of Cancer: An Innovative Treatment Comes of Age　p. 159-185　2016/02/22　Part of collection (book)

Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities

N. Tatsumi, N. Hojo, O. Yamada, M. Ogawa, Y. Katsura, S. Kawata, E. Morii, H. Sakamoto, R. Inaba, A. Tsuda, I. Fukuda, N. Moriguchi, H. Hasuwa, M. Okabe, F. Fujiki, S. Nishida, H. Nakajima, A. Tsuboi, Y. Oka, N. Hosen, H. Sugiyama, Y. Oji

ONCOGENE　Vol. 35　No. 8　p. 1003-1014　2016/02　Research paper (scientific journal)

Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy

Masahiro Azuma, Yohei Takeda, Hiroko Nakajima, Haruo Sugiyama, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya

ONCOIMMUNOLOGY　Vol. 5　No. 8　2016　Research paper (scientific journal)

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 10　No. 12　2015/12　Research paper (scientific journal)

Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients

Yoshiki Nakae, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Toshio Kamiya, Satoshi Takashima, Jun Nakata, Sumiyuki Nishida, Hiroko Nakajima, Naoki Hosen, Akihiro Tsuboi, Taiichi Kyo, Yusuke Oji, Kenji Mizuguchi, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 7　p. 791-804　2015/07　Research paper (scientific journal)

Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response

Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 6　p. 707-716　2015/06　Research paper (scientific journal)

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms

Naoya Tatsumi, Nozomi Hojo, Hiroyuki Sakamoto, Rena Inaba, Nahoko Moriguchi, Keiko Matsuno, Mari Fukuda, Akihide Matsumura, Seiji Hayashi, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Haruo Sugiyama, Yusuke Oji

PLOS ONE　Vol. 10　No. 6　2015/06　Research paper (scientific journal)

Transduction of a Novel HLA-DRB1*04:05-restricted, WT1-specific TCR Gene into Human CD4(+) T Cells Confers Killing Activity Against Human Leukemia Cells

Akiko Katsuhara, Fumihiro Fujiki, Nao Aoyama, Satoe Tanii, Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Kenta Kondo, Naoya Tatsumi, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Sumiyuki Nishida, Naoki Hosen, Shinji Sogo, Yusuke Oji, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 35　No. 3　p. 1251-1261　2015/03　Research paper (scientific journal)

Development of a dendritic cell-targeting lipopeptide as an immunoadjuvant that inhibits tumor growth without inducing local inflammation

Takashi Akazawa, Toshimitsu Ohashi, Hiroko Nakajima, Yasuko Nishizawa, Ken Kodama, Kikuya Sugiura, Toshio Inaba, Norimitsu Inoue

INTERNATIONAL JOURNAL OF CANCER　Vol. 135　No. 12　p. 2847-2856　2014/12　Research paper (scientific journal)

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity

J. Nakata, K. Nakano, A. Okumura, Y. Mizutani, H. Kinoshita, M. Iwai, K. Hasegawa, S. Morimoto, F. Fujiki, N. Tatsumi, H. Nakajima, Y. Nakae, S. Nishida, A. Tsuboi, Y. Oji, Y. Oka, H. Sugiyama, A. Kumanogoh, N. Hosen

LEUKEMIA　Vol. 28　No. 6　p. 1316-1325　2014/06　Research paper (scientific journal)

The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers

Yusuke Oji, Naoya Tatsumi, Mari Fukuda, Shin-Ichi Nakatsuka, Sayaka Aoyagi, Erika Hirata, Isamu Nanchi, Fumihiro Fujiki, Hiroko Nakajima, Yumiko Yamamoto, Syohei Shibata, Michiyo Nakamura, Kana Hasegawa, Sayaka Takagi, Ikuyo Fukuda, Tomoko Hoshikawa, Yui Murakami, Masahide Mori, Masayoshi Inoue, Tetsuji Naka, Takeshi Tomonaga, Yoshifumi Shimizu, Masashi Nakagawa, Junichi Hasegawa, Riichiro Nezu, Hidenori Inohara, Shuichi Izumoto, Norio Nonomura, Toshiki Yoshimine, Meinoshin Okumura, Eiichi Morii, Hajime Maeda, Sumiyuki Nishida, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 44　No. 5　p. 1461-1469　2014/05　Research paper (scientific journal)

eEF2の癌遺伝子様機能とeEF2特異的免疫応答の誘導(Oncogenic function of eEF2 in cancers and in vivo humoral and in vitro CTL responses against eEF2 protein)

尾路 祐介, 辰巳 直也, 福田 茉莉, 中塚 新一, 藤木 文博, 中島 博子, 長谷川 加奈, 根津 理一郎, 森井 英一, 坪井 昭博, 岡 芳弘, 杉山 治夫

日本癌学会総会記事　Vol. 72回　p. 367-367　2013/10

Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine

Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H

BLOOD CANCER JOURNAL　Vol. 3　No. 8　2013/08　Research paper (scientific journal)

Functional human Th17 clones with WT1-specific helper activity

Sho Tachino, Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Soyoko Morimoto, Yu-Hung Lin, Taichi Tamanaka, Kenta Kondo, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 62　No. 4　p. 801-810　2013/04　Research paper (scientific journal)

HLA-DPB1*05:01-restricted WT1 (332)-specific TCR-transduced CD4(+) T Lymphocytes Display a Helper Activity for WT1-specific CTL Induction and a Cytotoxicity Against Leukemia Cells

Yuhung Lin, Fumihiro Fujiki, Akiko Katsuhara, Yoshihiro Oka, Akihiro Tsuboi, Nao Aoyama, Satoe Tanii, Hiroko Nakajima, Naoya Tatsumi, Soyoko Morimoto, Taichi Tamanaka, Sho Tachino, Naoki Hosen, Sumiyuki Nishida, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 36　No. 3　p. 159-170　2013/04　Research paper (scientific journal)

Recognition of a Natural WT1 Epitope by a Modified WT1 Peptide-specific T-Cell Receptor

Taichi Tamanaka, Yoshihiro Oka, Fumihiro Fujiki, Akihiro Tsuboi, Akiko Katsuhara, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Yu-Hung Lin, Sho Tachino, Yoshiki Akatsuka, Kiyotaka Kuzushima, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 32　No. 12　p. 5201-5209　2012/12　Research paper (scientific journal)

CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients.

Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H

Leukemia　Vol. 26　No. 9　2012/09　Research paper (scientific journal)

Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors.

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

Cancer Sci.　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

Biased usage of T cell receptor ss-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+T cells in patients with solid tumors and healthy donors

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER SCIENCE　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

CD48 as a novel molecular target for antibody therapy in multiple myeloma.

Naoki Hosen, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Yuki Fukuda, Satoshi Kishida, Yoshikazu Matsuoka, Hiroko Nakajima, Manabu Kawakami, Tamotsu Yamagami, Shigeo Fuji, Hiroya Tamaki, Takafumi Nakao, Sumiyuki Nishida, Akihiro Tsuboi, Shinsuke Iida, Masayuki Hino, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama

British journal of haematology　Vol. 156　No. 2　p. 213-24　2012/01　Research paper (scientific journal)

CD48 as a novel molecular target for antibody therapy in multiple myeloma

Naoki Hosen, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Yuki Fukuda, Satoshi Kishida, Yoshikazu Matsuoka, Hiroko Nakajima, Manabu Kawakami, Tamotsu Yamagami, Shigeo Fuji, Hiroya Tamaki, Takafumi Nakao, Sumiyuki Nishida, Akihiro Tsuboi, Shinsuke Iida, Masayuki Hino, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama

BRITISH JOURNAL OF HAEMATOLOGY　Vol. 156　No. 2　p. 213-224　2012/01　Research paper (scientific journal)

Enhanced tumor immunity of WT1 peptide vaccination by interferon-beta administration

Hiroko Nakajima, Yoshihiro Oka, Akihiro Tsuboi, Naoya Tatsumi, Yumiko Yamamoto, Fumihiro Fujiki, Zheyu Li, Ayako Murao, Soyoko Morimoto, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Ichiro Kawase, Yoshitaka Isaka, Yusuke Oji, Haruo Sugiyama

VACCINE　Vol. 30　No. 4　p. 722-729　2012/01　Research paper (scientific journal)

WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient

Yusuke Oji, Yoshihiro Oka, Sumiyuki Nishida, Akihiro Tsuboi, Manabu Kawakami, Toshiaki Shirakata, Kazuko Takahashi, Ayako Murao, Hiroko Nakajima, Miwako Narita, Masuhiro Takahashi, Satoshi Morita, Junichi Sakamoto, Toshio Tanaka, Ichiro Kawase, Naoki Hosen, Haruo Sugiyama

EUROPEAN JOURNAL OF HAEMATOLOGY　Vol. 85　No. 4　p. 358-360　2010/10　Research paper (scientific journal)

A Clear Correlation between WT1-specific Th Response and Clinical Response in WT1 CTL Epitope Vaccination

Fumihiro Fujiki, Yoshihiro Oka, Mai Kawakatsu, Akihiro Tsuboi, Yukie Tanaka-Harada, Naoki Hosen, Sumiyuki Nishida, Toshiaki Shirakata, Hiroko Nakajima, Naoya Tatsumi, Naoya Hashimoto, Tetsuya Taguchi, Satsuki Ueda, Norio Nonomura, Yutaka Takeda, Toshinori Ito, Akira Myoui, Shuichi Izumoto, Motohiko Maruno, Toshiki Yoshimine, Shinzaburo Noguchi, Akihiko Okuyama, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 30　No. 6　p. 2247-2254　2010/06　Research paper (scientific journal)

High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients: an important role of bone marrow as a secondary lymphoid organ.

Ayako Murao, Yoshihiro Oka, Akihiro Tsuboi, Olga A Elisseeva, Yukie Tanaka-Harada, Fumihiro Fujiki, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Toshiaki Shirakata, Nobuyuki Hashimoto, Akira Myoui, Takafumi Ueda, Yoshito Takeda, Tadashi Osaki, Takayuki Enomoto, Hideki Yoshikawa, Tadashi Kimura, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

Cancer Sci.　Vol. 101　No. 4　p. 848-854　2010/04　Research paper (scientific journal)

High frequencies of less differentiated and more proliferative WT1-specific CD8+T cells in bone marrow in tumor-bearing patients: An important role of bone marrow as a secondary lymphoid organ

Ayako Murao, Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Yukie Tanaka-Harada, Fumihiro Fujiki, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Toshiaki Shirakata, Nobuyuki Hashimoto, Akira Myoui, Takafumi Ueda, Yoshito Takeda, Tadashi Osaki, Takayuki Enomoto, Hideki Yoshikawa, Tadashi Kimura, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

CANCER SCIENCE　Vol. 101　No. 4　p. 848-854　2010/04　Research paper (scientific journal)

Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies.

Yukie Tanaka-Harada, Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Takamasa Katagiri, Olga A Elisseeva, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Fumihiro Fujiki, Ayako Murao, Hiroko Nakajima, Yusuke Oji, Yoshinobu Kanda, Ichiro Kawase, Haruo Sugiyama

Cancer Sci.　Vol. 101　No. 3　p. 594-600　2010/03　Research paper (scientific journal)

Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8(+) T cells in patients with myeloid malignancies

Yukie Tanaka-Harada, Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Takamasa Katagiri, Olga A. Elisseeva, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Fumihiro Fujiki, Ayako Murao, Hiroko Nakajima, Yusuke Oji, Yoshinobu Kanda, Ichiro Kawase, Haruo Sugiyama

CANCER SCIENCE　Vol. 101　No. 3　p. 594-600　2010/03　Research paper (scientific journal)

WT1 peptide vaccine as a paradigm for "cancer antigen-derived peptide"-based immunotherapy for malignancies: successful induction of anti-cancer effect by vaccination with a single kind of WT1 peptide.

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Zheyu Li, Hiroko Nakajima, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

Anti-cancer agents in medicinal chemistry　Vol. 9　No. 7　p. 787-97　2009/09　Research paper (scientific journal)

WT1 Peptide Vaccine as a Paradigm for "Cancer Antigen-Derived Peptide"-Based Immunotherapy for Malignancies: Successful Induction of Anti-Cancer Effect by Vaccination with a Single Kind of WT1 Peptide

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Zheyu Li, Hiroko Nakajima, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY　Vol. 9　No. 7　p. 787-797　2009/09　Research paper (scientific journal)

"Cancer Antigen WT1 Protein-Derived Peptide"-Based Treatment of Cancer - Toward the Further Development

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Hiroko Nakajima, Zheyu Li, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

CURRENT MEDICINAL CHEMISTRY　Vol. 15　No. 29　p. 3052-3061　2008/12　Research paper (scientific journal)

A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells

Fumihiro Fujiki, Yoshihiro Oka, Mai Kawakatsu, Akihiro Tsuboi, Hiroko Nakajima, Olga A. Elisseeva, Yukie Harada, Zheyu Li, Naoko Tatsumi, Eriko Kamino, Toshiaki Shirakata, Sumiyuki Nishida, Yuki Taniguchi, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 52　No. 12　p. 591-600　2008/12　Research paper (scientific journal)

Differential radiation sensitivity to morphological, functional and molecular changes of human thyroid tissues and bone marrow cells maintained in SCID mice.

Nomura T, Hongyo T, Nakajima H, Li LY, Syaifudin M, Adachi S, Ryo H, Baskar R, Fukuda K, Oka Y, Sugiyama H, Matsuzuka F

Mutation research　Vol. 657　No. 1　p. 68-76　2008/11

Identification of a WT1 protein-derived peptide, WT1(187), as a HLA-A*0206-restricted, WT1-specific CTL epitope

Zheyu Li, Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Yukie Harada, Hiroko Nakajima, Tomoki Masuda, Yoko Fukuda, Mai Kawakatsu, Soyoko Morimoto, Takamasa Katagiri, Naoya Tatsumi, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yutaka Kawakami, Keiko Udaka, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 52　No. 11　p. 551-558　2008/11　Research paper (scientific journal)

"Cancer antigen WT1 protein-derived peptide"-based treatment of cancer -toward the further development.

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Hiroko Nakajima, Zheyu Li, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

Current medicinal chemistry　Vol. 15　No. 29　p. 3052-61　2008　Research paper (scientific journal)

Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma.

Akihiro Tsuboi, Yoshihiro Oka, Hiroko Nakajima, Yoko Fukuda, Olga A Elisseeva, Satoshi Yoshihara, Naoki Hosen, Atsushi Ogata, Katsuyuki Kito, Fumihiro Fujiki, Sumiyuki Nishida, Toshiaki Shirakata, Satoshi Ohno, Masaki Yasukawa, Yusuke Oji, Manabu Kawakami, Satoshi Morita, Junichi Sakamoto, Keiko Udaka, Ichiro Kawase, Haruo Sugiyama

International journal of hematology　Vol. 86　No. 5　p. 414-7　2007/12　Research paper (scientific journal)

Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma

Akihiro Tsuboi, Yoshihiro Oka, Hiroko Nakajima, Yoko Fukuda, Olga A. Elisseeva, Satoshi Yoshihara, Naoki Hosen, Atsushi Ogata, Katsuyuki Kito, Fumihiro Fujiki, Sumiyuki Nishida, Toshiaki Shirakata, Satoshi Ohno, Masaki Yasukawa, Yusuke Oji, Manabu Kawakami, Satoshi Morita, Junichi Sakamoto, Keiko Udaka, Ichiro Kawase, Haruo Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 86　No. 5　p. 414-417　2007/12　Research paper (scientific journal)

Clinical and immunologic responses to very low-dose vaccination with WT1 peptide (5 mu g/body) in a patient with chronic myelomonocytic leukemia

Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Yukie Harada, Olga A. Elisseeva, Yoshio Furukawa, Machiko Tsukaguchi, Toshiaki Shirakata, Sumiyuki Nishida, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 85　No. 5　p. 426-429　2007/06　Research paper (scientific journal)

WT1 peptide cancer vaccine for patients with hematopoietic malignancies and solid cancers.

Oka Y, Tsuboi A, Elisseeva OA, Nakajima H, Fujiki F, Kawakami M, Shirakata T, Nishida S, Hosen N, Oji Y, Kawase I, Sugiyama H

TheScientificWorldJournal　Vol. 7　p. 649-665　2007/05　Research paper (scientific journal)

Identification and characterization of a WT1 (Wilms tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes

Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Manabu Kawakami, Mai Kawakatsu, Hiroko Nakajima, Olga A. Elisseeva, Yukie Harada, Ken Ito, Zheyu Li, Naoya Tatsumi, Nao Sakaguchi, Tatsuya Fujioka, Tomoki Masuda, Masaki Yasukawa, Keiko Udaka, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 30　No. 3　p. 282-293　2007/04　Research paper (scientific journal)

WT1 peptide cancer vaccine for patients with hematopoietic malignancies and solid cancers

Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

THESCIENTIFICWORLDJOURNAL　Vol. 7　p. 649-665　2007　Research paper (scientific journal)

WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma

Tatsuo Iiyama, Keiko Udaka, Sachihiko Takeda, Tamotsu Takeuchi, Yoshihiro C. Adachi, Yuji Ohtsuki, Akihiro Tsuboi, Shin-ichi Nakatsuka, Olga A. Elisseeva, Yusuke Oji, Manabu Kawakami, Hiroko Nakajima, Sumiyuki Nishida, Toshiaki Shirakata, Yoshihiro Oka, Taro Shuin, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 51　No. 5　p. 519-530　2007　Research paper (scientific journal)

OP-302 WT1抗原を標的とした泌尿器科癌に対するペプチドワクチン療法の第I/II相臨床試験(一般演題口演,第94回日本泌尿器科学会総会)

飯山 達雄, 宇高 恵子, 竹内 保, 大朏 祐治, 中島 博子, 岡 芳弘, 坪井 昭博, 尾路 祐介, 杉山 治夫, 執印 太郎

日本泌尿器科学会雑誌　Vol. 97　No. 2　p. 356-356　2006

WT1(235), a ninemer peptide derived from Wilms' tumor gene product, is a candidate peptide for the vaccination of HLA-A*0201-positive patients with hematopoietic malignancies

ZY Li, Y Oka, A Tsuboi, T Masuda, N Tatsumi, M Kawakami, T Fujioka, N Sakaguchi, H Nakajima, F Fujiki, K Udaka, Y Oji, Kawase, I, H Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 82　No. 5　p. 458-459　2005/12

Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.

Wu F, Oka Y, Tsuboi A, Elisseeva OA, Ogata K, Nakajima H, Fujiki F, Masuda T, Murakami M, Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K　Vol. 19　p. 268-274　2005/02

Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression

Y Oka, A Tsuboi, T Taguchi, T Osaki, T Kyo, H Nakajima, OA Elisseeva, Y Oji, M Kawakami, K Ikegame, N Hosen, S Yoshihara, F Wu, F Fujiki, M Murakami, T Masuda, S Nishida, T Shirakata, S Nakatsuka, A Sasaki, K Udaka, H Dohy, K Aozasa, S Noguchi, L Kawase, H Sugiyama

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 101　No. 38　p. 13885-13890　2004/09　Research paper (scientific journal)

WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone

H Nakajima, K Kawasaki, Y Oka, A Tsuboi, M Kawakami, K Ikegame, Y Hoshida, F Fujiki, A Nakano, T Masuda, F Wu, Y Taniguchi, S Yoshihara, OA Elisseeva, Y Oji, H Ogawa, Azuma, I, Kawase, I, K Aozasa, H Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 53　No. 7　p. 617-624　2004/07　Research paper (scientific journal)

WT1 peptide-based immunotherapy for patients with lung cancer: Report of two cases

A Tsuboi, Y Oka, T Osaki, T Kumagai, Tachibana, I, S Hayashi, M Murakami, H Nakajima, OA Elisseeva, W Fei, T Masuda, M Yasukawa, Y Oji, M Kawakami, N Hosen, K Ikegame, S Yoshihara, K Udaka, S Nakatsuka, K Aozasa, L Kawase, H Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 48　No. 3　p. 175-184　2004　Research paper (scientific journal)

Wilms tumor gene peptide-based immunotherapy for patients with overt leukemia from myelodysplastic syndrome (MDS) or MDS with myelofibrosis

Y Oka, A Tsuboi, M Murakami, M Hirai, N Tominaga, H Nakajima, OA Elisseeva, T Masuda, A Nakano, M Kawakami, Y Oji, K Ikegame, N Hosen, K Udaka, M Yasukawa, H Ogawa, L Kawase, H Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 78　No. 1　p. 56-61　2003/07　Research paper (scientific journal)

The lck promoter-driven expression of the Wilms tumor gene WT1 blocks intrathymic differentiation of T-lineage cells

H Li, Y Oka, A Tsuboi, T Yamagami, T Miyazaki, S Yusa, K Kawasaki, Y Kishimoto, M Asada, H Nakajima, K Kanato, S Nishida, T Masuda, M Murakami, N Hosen, M Kawakami, H Ogawa, F Melchers, Kawase, I, Y Oji, H Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 77　No. 5　p. 463-470　2003/06　Research paper (scientific journal)

Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A*2402-binding residues

A Tsuboi, Y Oka, K Udaka, M Murakami, T Masuda, A Nakano, H Nakajima, M Yasukawa, A Hiraki, Y Oji, M Kawakami, N Hosen, T Fujioka, F Wu, Y Taniguchi, S Nishida, M Asada, H Ogawa, Kawase, I, H Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 51　No. 11-12　p. 614-620　2002/12　Research paper (scientific journal)