顔写真

PHOTO

Nakai Wataru
中井　渉
Nakai Wataru
中井　渉
Graduate School of Medicine　Division of Medicine, Assistant Professor

keyword MHC，Exosome

Research History 2

  1. 2006 - 2010
    National Institute of Environmental Health Sciences / NIH　Visiting Fellow

  2. 2003 - 2006
    Osaka University　Graduate School of Frontier Biosciences

Professional Memberships 1

  1. 日本免疫学会

Research Areas 3

  1. Life sciences / Medical biochemistry /

  2. Life sciences / Immunology /

  3. Life sciences / Molecular biology /

Papers 14

  1. Neoself-antigens are the primary target for autoreactive T cells in human lupus.

    Shunsuke Mori, Masako Kohyama, Yoshiaki Yasumizu, Asa Tada, Kaito Tanzawa, Tatsuya Shishido, Kazuki Kishida, Hui Jin, Masayuki Nishide, Shoji Kawada, Daisuke Motooka, Daisuke Okuzaki, Ryota Naito, Wataru Nakai, Teru Kanda, Takayuki Murata, Chikashi Terao, Koichiro Ohmura, Noriko Arase, Tomohiro Kurosaki, Manabu Fujimoto, Tadahiro Suenaga, Atsushi Kumanogoh, Shimon Sakaguchi, Yoshihiro Ogawa, Hisashi Arase

    Cell　2024/09/11　Research paper (scientific journal)

  2. Positive and negative regulation of the Fcγ receptor-stimulating activity of RNA-containing immune complexes by RNase.

    Ryota Naito, Koichiro Ohmura, Shuhei Higuchi, Wataru Nakai, Masako Kohyama, Tsuneyo Mimori, Akio Morinobu, Hisashi Arase

    JCI insight　Vol. 8　No. 16　2023/08/22　Research paper (scientific journal)

  3. SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.

    Masako Kohyama, Tatsuya Suzuki, Wataru Nakai, Chikako Ono, Sumiko Matsuoka, Koichi Iwatani, Yafei Liu, Yusuke Sakai, Atsushi Nakagawa, Keisuke Tomii, Koichiro Ohmura, Masato Okada, Yoshiharu Matsuura, Shiro Ohshima, Yusuke Maeda, Toru Okamoto, Hisashi Arase

    International immunology　Vol. 35　No. 1　p. 43-52　2023/01/21　Research paper (scientific journal)

  4. Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.

    Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase

    Science advances　Vol. 8　No. 9　2022/03/04　Research paper (scientific journal)

  5. The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

    Yafei Liu, Noriko Arase, Jun-ichi Kishikawa, Mika Hirose, Songling Li, Asa Tada, Sumiko Matsuoka, Akemi Arakawa, Kanako Akamatsu, Chikako Ono, Hui Jin, Kazuki Kishida, Wataru Nakai, Masako Kohyama, Atsushi Nakagawa, Yoshiaki Yamagishi, Hironori Nakagami, Atsushi Kumanogoh, Yoshiharu Matsuura, Daron M. Standley, Takayuki Kato, Masato Okada, Manabu Fujimoto, Hisashi Arase

    2021/08/23

    Publisher: Cold Spring Harbor Laboratory

  6. An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

    Yafei Liu, Wai Tuck Soh, Jun ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Takayuki Kato, Masato Okada, Daron M. Standley, Tatsuo Shioda, Hisashi Arase

    Cell　Vol. 184　No. 13　p. 3452-3466.e18　2021/06/24　Research paper (scientific journal)

  7. Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2

    Akihito Sakoguchi, Fumiji Saito, Kouyuki Hirayasu, Kyoko Shida, Sumiko Matsuoka, Sawako Itagaki, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Shiroh Iwanaga, Toshihiro Horii, Hisashi Arase

    Biochemical and Biophysical Research Communications　Vol. 548　p. 167-173　2021/04　Research paper (scientific journal)

    Publisher: Elsevier BV

  8. Invariant chain p41 mediates production of soluble MHC class II molecules

    Tatsuya Shishido, Masako Kohyama, Wataru Nakai, Maki Matsumoto, Haruhiko Miyata, Tadahiro Suenaga, Hisashi Arase

    Biochemical and Biophysical Research Communications　Vol. 509　No. 1　p. 216-221　2019/01/29　Research paper (scientific journal)

  9. A novel affinity-based method for the isolation of highly purified extracellular vesicles

    Wataru Nakai, Takeshi Yoshida, Diego Diez, Yuji Miyatake, Takahiro Nishibu, Naoko Imawaka, Ken Naruse, Yoshifusa Sadamura, Rikinari Hanayama

    Scientific Reports　Vol. 6　p. 33935-33935　2016/09/23　Research paper (scientific journal)

  10. Chromosome integrity at a double-strand break requires exonuclease 1 and MRX

    Wataru Nakai, Jim Westmoreland, Elaine Yeh, Kerry Bloom, Michael A. Resnick

    DNA Repair　Vol. 10　No. 1　p. 102-110　2011/01/02　Research paper (scientific journal)

  11. Characterizing resection at random and unique chromosome double-strand breaks and telomere ends.

    Wenjian Ma, Jim Westmoreland, Wataru Nakai, Anna Malkova, Michael A. Resnick

    Methods in molecular biology (Clifton, N.J.)　Vol. 745　p. 15-31　2011　Research paper (scientific journal)

  12. The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint

    Hiroo Ogi, Cheng Zhong Wang, Wataru Nakai, Yasuo Kawasaki, Hiroshi Masumoto

    Gene　Vol. 414　No. 1-2　p. 32-40　2008/05/15　Research paper (scientific journal)

  13. Fidelity of DNA polymerase ε holoenzyme from budding yeast Saccharomyces cerevisiae

    Kikuo Shimizu, Keiji Hashimoto, Jake M. Kirchner, Wataru Nakai, Hiroko Nishikawa, Michael A. Resnick, Akio Sugino

    Journal of Biological Chemistry　Vol. 277　No. 40　p. 37422-37429　2002/10/04　Research paper (scientific journal)

  14. Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells

    Makoto Kihara, Wataru Nakai, Satoshi Asano, Akiko Suzuki, Kunio Kitada, Yasuo Kawasaki, Leland H. Johnston, Akio Sugino

    Journal of Biological Chemistry　Vol. 275　No. 45　p. 35051-35062　2000/11/10　Research paper (scientific journal)

Misc. 1

  1. Pathogenesis of autoimmune disease by MHC class II molecules

    Wataru Nakai, Hisashi Arase

    2020/07　Article, review, commentary, editorial, etc. (scientific journal)

Presentations 2

  1. Function of ectopic MHC class II expression on non-immune cells in immune response

    Wataru Nakai

    第52回日本免疫学会学術集会　2024/01

  2. A new transcriptional mechanism of ectopic MHC class II expression induced by IFN-γ

    Wataru Nakai, Yuta Shimizu, Masako Kohyama, Hisashi Arase

    The 51st Annual Meeting of The Japanese Society for Immunology　2022/12/09