大阪大学大学院 薬学研究科 高分子化学分野
2014/04 - 2018/03
北海道大学大学院 農学院 応用生物科学専攻
2007/04 - 2009/03
Hokkaido University Faculty of Agriculture Department of Bioscience and Chemistry
2003/04 - 2007/03
日本生物工学会 第７４回大会 実行委員会（プログラム・トピック担当） Academic society
2022/10 - 2022/10
日本動物細胞工学会 第44回シンポジウム オーガナイザー Academic society
2022/03 - 2022/03
日本動物細胞工学会 第43回シンポジウム オーガナイザー Academic society
2021/11 - 2021/11
日本農芸化学会
日本食品科学工学会
Japanese Association for Animal Cell Technology
The Society for Biotechnology, Japan
The Pharmaceutical Society of Japan
Life sciences / Food sciences /
Life sciences / Pharmaceuticals - analytical and physicochemistry /
Unfolding of viral protein 1 N-termini facilitates genome ejection from recombinant adeno-associated virus serotype 8.
Yuki Yamaguchi, Saki Shimojo, Tomohiko Ikeda, Mitsuko Fukuhara, Yasuo Tsunaka, Risa Shibuya, Mark Allen Vergara Rocafort, Ryoji Nakatsuka, Kiichi Hirohata, Tetsuo Torisu, Susumu Uchiyama
Molecular therapy. Methods & clinical development Vol. 33 No. 2 p. 101480-101480 2025/06/12 Research paper (scientific journal)
Direct Identification and Quantification of Recombinant Adeno-Associated Virus in Crude Cell Lysate and Conditioned Medium by Mass Photometry.
Yuki Yamaguchi, Saki Shimojo, Risa Shibuya, Karin Bandoh, Aoba Matsushita, Mitsuko Fukuhara, Yasuo Tsunaka, Tetsuo Torisu, Susumu Uchiyama
Analytical chemistry Vol. 97 No. 19 p. 10405-10416 2025/05/20 Research paper (scientific journal)
Use of cesium chloride density gradient ultracentrifugation for the purification and characterization of recombinant adeno-associated virus.
Kiichi Hirohata, Shinichiro Kino, Takuya Yamane, Karin Bandoh, Takeshi Bamba, Shawn M Sternisha, Tetsuo Torisu, Mitsuko Fukuhara, Yuki Yamaguchi, Susumu Uchiyama
European biophysics journal : EBJ 2025/05/19 Research paper (scientific journal)
Hierarchical clustering of therapeutic proteins based on agitation-induced aggregation propensity and its relation to physicochemical parameters.
Rio Okada, Kosei Shibata, Risa Shibuya, Tetsuo Torisu, Susumu Uchiyama
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Vol. 208 p. 107060-107060 2025/05/01 Research paper (scientific journal)
Survey and Establishment of Points to Consider for Application of Analytical Techniques to Evaluate Protein Aggregates and Insoluble Particles in Biopharmaceuticals: Experiences in Japan Biopharmaceutical Consortium.
Hiroko Shibata, Satoshi Saitoh, Masato Kiyoshi, Yu Hayashi, Kazue Inaba, Shinji Katsura, Maho Sakurai, Yuka Komine, Shinji Okabe, Naomi Ohbayashi, Youko Kita, Hirokazu Kito, Masako Nakano, Kana Miyamoto, Akira Maruyama, Yuya Miyahara, Masanori Noda, Yasuyo Nozawa, Kazutaka Shimbo, Shota Kojima, Shinya Honda, Tetsuo Torisu, Susumu Uchiyama, Akiko Ishii-Watabe
The AAPS journal.. Vol. 27 No. 3 p. 75-75 2025/04/03 Research paper (scientific journal)
Protein aggregation in the frozen state induced by dropping stress
Tetsuo Torisu, Ayuko Maeda, Shuhei Ito, Susumu Uchiyama
European Journal of Pharmaceutical Sciences 2025/02 Research paper (scientific journal)
Impact of Weak Vibration Generated by a Refrigerator on Protein Aggregation.
Shinji Kizuki, Zekun Wang, Satoru Yamauchi, Tetsuo Torisu, Susumu Uchiyama
The AAPS journal.. Vol. 27 No. 1 p. 34-34 2025/01/27 Research paper (scientific journal)
Physicochemical and biological impacts of light stress on adeno-associated virus serotype 6
Rie Takino, Yuki Yamaguchi, Takahiro Maruno, Ekaputra Ramadhani, Misaki Furukawa, Tetsuo Torisu, Susumu Uchiyama
Molecular Therapy - Methods & Clinical Development 2024/12 Research paper (scientific journal)
Multimass Analysis of Adeno-Associated Virus Vectors by Orbitrap-Based Charge Detection Mass Spectrometry
Ryoji Nakatsuka, Yuki Yamaguchi, Kiichi Hirohata, Saki Shimojo, Makoto Murakami, Mark Allen Vergara Rocafort, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Analytical Chemistry 2024/10/22 Research paper (scientific journal)
Quantification of full and empty particles of adeno-associated virus vectors via a novel dual fluorescence-linked immunosorbent assay.
Sereirath Soth, Mikako Takakura, Masahiro Suekawa, Takayuki Onishi, Kiichi Hirohata, Tamami Hashimoto, Takahiro Maruno, Mitsuko Fukuhara, Yasuo Tsunaka, Tetsuo Torisu, Susumu Uchiyama
Molecular therapy. Methods & clinical development Vol. 32 No. 3 p. 101291-101291 2024/09/12 Research paper (scientific journal)
Prediction models for the flux decay profile and initial flux of microfiltration for therapeutic proteins
Kota Inoue, Yumiko Masuda, Tetsuo Torisu, Koichi Nonaka, Susumu Uchiyama
Biotechnology and Bioengineering Vol. 121 No. 6 p. 1889-1901 2024/06 Research paper (scientific journal)
Structure of Human Serum Albumin at a Foam Surface
Kanta Enomoto, Tetsuo Torisu, Junya Mizuguchi, Ryosuke Tanoue, Susumu Uchiyama
Journal of Agricultural and Food Chemistry Vol. 72 No. 15 p. 8774-8783 2024/04/17 Research paper (scientific journal)
Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass Spectrometry
Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Viruses Vol. 16 No. 4 2024/04/10 Research paper (scientific journal)
Glycosylation of recombinant adeno-associated virus serotype 6
Yuki Yamaguchi, Kentaro Ishii, Sachiko Koizumi, Hiroaki Sakaue, Takahiro Maruno, Mitsuko Fukuhara, Risa Shibuya, Yasuo Tsunaka, Aoba Matsushita, Karin Bandoh, Tetsuo Torisu, Chie Murata-Kishimoto, Azusa Tomioka, Saho Mizukado, Hiroyuki Kaji, Yuji Kashiwakura, Tsukasa Ohmori, Atsushi Kuno, Susumu Uchiyama
Molecular Therapy - Methods & Clinical Development 2024/04 Research paper (scientific journal)
Combined 100 keV cryo-electron microscopy and image analysis methods to characterize the wider adeno-associated viral products.
Haruka Nishiumi, Kiichi Hirohata, Mitsuko Fukuhara, Aoba Matsushita, Yasuo Tsunaka, Mark Allen Vergara Rocafort, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama
Journal of pharmaceutical sciences 2024/04/01 Research paper (scientific journal)
Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for the Quantitative Characterization of Adeno-Associated Virus Vectors.
Kiichi Hirohata, Yuki Yamaguchi, Takahiro Maruno, Risa Shibuya, Tetsuo Torisu, Takayuki Onishi, Hideto Chono, Junichi Mineno, Yuan Yuzhe, Kiyoko Higashiyama, Kyoko Masumi-Koizumi, Kazuhisa Uchida, Takenori Yamamoto, Eriko Uchida, Takashi Okada, Susumu Uchiyama
Analytical chemistry 2024/01/02 Research paper (scientific journal)
Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly.
Takayuki Onishi, Michika Nonaka, Takahiro Maruno, Yuki Yamaguchi, Mitsuko Fukuhara, Tetsuo Torisu, Masaharu Maeda, Susan Abbatiello, Anisha Haris, Keith Richardson, Kevin Giles, Steve Preece, Noriko Yamano-Adachi, Takeshi Omasa, Susumu Uchiyama
Molecular therapy. Methods & clinical development Vol. 31 p. 101142-101142 2023/12/14 Research paper (scientific journal)
Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs.
Dominik Brandstetter, Constanze Helbig, Kentaro Osawa, Hiroyuki Minemura, Yumiko Anzai, Tetsuo Torisu, Susumu Uchiyama, Tim Menzen, Wolfgang Friess, Andrea Hawe
Journal of pharmaceutical sciences 2023/11/03 Research paper (scientific journal)
Optimization of Flow Imaging Microscopy Setting Using Spherical Beads with Optical Properties Similar to Those of Biopharmaceuticals.
Takaaki Kurinomaru, Kimitoshi Takeda, Megumi Onaka, Yuki Kuruma, Keiji Takahata, Kayori Takahashi, Hiromu Sakurai, Akira Sasaki, Naohiro Noda, Shinya Honda, Risa Shibuya, Tomohiko Ikeda, Rio Okada, Tetsuo Torisu, Susumu Uchiyama
Journal of pharmaceutical sciences 2023/10/07 Research paper (scientific journal)
Size Distribution Analysis of the Adeno-Associated Virus Vector by the c(s) Analysis of Band Sedimentation Analytical Ultracentrifugation with Multiwavelength Detection.
Takahiro Maruno, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama
Journal of pharmaceutical sciences Vol. 112 No. 4 p. 937-946 2023/04 Research paper (scientific journal)
Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals.
Haruka Nishiumi, Natalie Deiringer, Nils Krause, Saki Yoneda, Tetsuo Torisu, Tim Menzen, Wolfgang Friess, Susumu Uchiyama
Journal of pharmaceutical sciences Vol. 111 No. 11 p. 3017-3028 2022/11 Research paper (scientific journal)
Relationship between aggregation of therapeutic proteins and agitation parameters: Acceleration and frequency.
Shinji Kizuki, Zekun Wang, Tetsuo Torisu, Satoru Yamauchi, Susumu Uchiyama
Journal of pharmaceutical sciences Vol. 112 No. 2 p. 492-505 2022/09/24 Research paper (scientific journal)
バイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第3回)[最終回] バイオ医薬品CMC研究開発におけるDigitizationおよびDigitalizationに関する事例紹介
末友 裕行, 柴田 寛子, 高垣 香菜, 山口 祐希, 叶井 正樹, 本山 賢人, 江連 徹, 西風 隆司, 早川 禎宏, 大澤 賢太郎, 桂 真治, 中子 真由美, 馬場 一彦, 丸吉 京介, 三原 和敏, 湯村 恭平, 日向 昌司, 原園 景, 鳥巣 哲生, 内山 進, 石井 明子
PHARM TECH JAPAN Vol. 38 No. 12 p. 2035-2047 2022/09
Publisher: (株)じほうバイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第2回) バイオ医薬品の製法開発や品質評価における分析結果および分析機器のDigitizationおよびDigitalizationの現状
末友 裕行, 大澤 賢太郎, 西風 隆司, 早川 禎宏, 柴田 寛子, 高垣 香菜, 桂 真治, 中子 真由美, 馬場 一彦, 丸吉 京介, 三原 和敏, 湯村 恭平, 日向 昌司, 原園 景, 鳥巣 哲生, 内山 進, 石井 明子
PHARM TECH JAPAN Vol. 38 No. 11 p. 1825-1830 2022/08
Publisher: (株)じほうA collaborative study on the classification of silicone oil droplets and protein particles using flow imaging method.
Hiroko Shibata, Masahiro Terabe, Yuriko Shibano, Satoshi Saitoh, Tomohiro Takasugi, Yu Hayashi, Shinji Okabe, Yuka Yamaguchi, Hidehito Yasukawa, Hiroyuki Suetomo, Kazuhiro Miyanabe, Naomi Ohbayashi, Michiko Akimaru, Shuntaro Saito, Daisuke Ito, Atsushi Nakano, Shota Kojima, Yuya Miyahara, Kenji Sasaki, Takahiro Maruno, Masanori Noda, Masato Kiyoshi, Akira Harazono, Tetsuo Torisu, Susumu Uchiyama, Akiko Ishii-Watabe
Journal of pharmaceutical sciences Vol. 111 No. 10 p. 2745-2757 2022/07/12 Research paper (scientific journal)
バイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第1回) バイオ医薬品CMC研究開発におけるDigitizationおよびDigitalizationにお関する現状
末友 裕行, 桂 真治, 高垣 香菜, 中子 真由美, 馬場 一彦, 丸吉 京介, 三原 和敏, 湯村 恭平, 日向 昌司, 原園 景, 柴田 寛子, 鳥巣 哲生, 内山 進, 石井 明子
PHARM TECH JAPAN Vol. 38 No. 10 p. 1599-1605 2022/07
Publisher: (株)じほうThe Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa
Yuki Yamaguchi, Natsumi Wakaizumi, Mine Irisa, Takahiro Maruno, Mari Shimada, Koya Shintani, Haruka Nishiumi, Rina Yogo, Saeko Yanaka, Daisuke Higo, Tetsuo Torisu, Koichi Kato, Susumu Uchiyama
mAbs Vol. 14 No. 1 p. 2038531-2038531 2022/03/16 Research paper (scientific journal)
Publisher: Informa UK Limited
Influence of Protein Adsorption on Aggregation in Prefilled Syringes
Saki Yoneda, Takahiro Maruno, Asuka Mori, Ayana Hioki, Haruka Nishiumi, Rio Okada, Makoto Murakami, Wang Zekun, Ayano Fukuhara, Nozomi Itagaki, Yosuke Harauchi, Satoru Adachi, Kumi Okuyama, Taichi Sawaguchi, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 110 No. 11 p. 3568-3579 2021/11 Research paper (scientific journal)
Publisher: Elsevier BV
Reduction of Recombinant Adeno-associated Virus Vector Adsorption on Solid Surfaces by Polyionic Hydrophilic Complex Coating
Salama Ramy, Yuki Ueda, Hiroyuki Nakajima, Miya Hiroi, Yoshiomi Hiroi, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences 2021/10 Research paper (scientific journal)
Publisher: Elsevier BV
Characterization of Adeno-Associated Virus Capsid Proteins with Two Types of VP3-Related Components by Capillary Gel Electrophoresis and Mass Spectrometry.
Hiroaki Oyama, Kentaro Ishii, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama
Human gene therapy Vol. 32 No. 21-22 p. 1403-1416 2021/07/16 Research paper (scientific journal)
Comprehensive size distribution and composition analysis of adeno-associated virus vector by multiwavelength sedimentation velocity analytical ultracentrifugation.
Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama
Journal of pharmaceutical sciences Vol. 110 No. 10 p. 3375-3384 2021/06/26 Research paper (scientific journal)
Physicochemical Characterization of Sabin Inactivated Poliovirus Vaccine for Process Development
Tetsuo Torisu, Saori Shikama, Kuniaki Nakamura, Kanta Enomoto, Takahiro Maruno, Asuka Mori, Susumu Uchiyama, Tatsuki Satou
Journal of Pharmaceutical Sciences Vol. 110 No. 5 p. 2121-2129 2021/05 Research paper (scientific journal)
Publisher: Elsevier BV
Development of syringes and vials for delivery of biologics: current challenges and innovative solutions.
Saki Yoneda, Tetsuo Torisu, Susumu Uchiyama
Expert opinion on drug delivery Vol. 18 No. 4 p. 459-470 2021/04 Research paper (scientific journal)
Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan
Akiko Ishii-Watabe, Hiroko Shibata, Hiroyuki Suetomo, Yosuke Ikeda, Srivalli Telikepalli, Masato Kiyoshi, Yu Hayashi, Takashi Muto, Yukako Tanaka, Satomi Ueda, Takafumi Iwura, Satoshi Saitoh, Michihiko Aoyama, Akira Harazono, Masashi Hyuga, Yukihiro Goda, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 109 No. 5 p. 1652-1661 2020/05
Automatic Identification of the Stress Sources of Protein Aggregates Using Flow Imaging Microscopy Images
Arni Gambe-Gilbuena, Yuriko Shibano, Elena Krayukhina, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 109 No. 1 p. 614-623 2020/01 Research paper (scientific journal)
Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody
Hiroaki Oyama, Hiroki Koga, Takashi Tadokoro, Katsumi Maenaka, Akira Shiota, Masami Yokoyama, Masanori Noda, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 109 No. 1 p. 308-315 2020/01 Research paper (scientific journal)
The Fab portion of immunoglobulin G contributes to its binding to Fcγ receptor III
Rina Yogo, Yuki Yamaguchi, Hiroki Watanabe, Hirokazu Yagi, Tadashi Satoh, Mahito Nakanishi, Masayoshi Onitsuka, Takeshi Omasa, Mari Shimada, Takahiro Maruno, Tetsuo Torisu, Shio Watanabe, Daisuke Higo, Takayuki Uchihashi, Saeko Yanaka, Susumu Uchiyama, Koichi Kato
Scientific Reports Vol. 9 No. 1 p. 11957-11957 2019/12/01 Research paper (scientific journal)
Identification of IgG1 Aggregation Initiation Region by Hydrogen Deuterium Mass Spectrometry
Masanori Noda, Kentaro Ishii, Mika Yamauchi, Hiroaki Oyama, Takashi Tadokoro, Katsumi Maenaka, Tetsuo Torisu, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 108 No. 7 p. 2323-2333 2019/07 Research paper (scientific journal)
Collaborative Study for Analysis of Subvisible Particles Using Flow Imaging and Light Obscuration: Experiences in Japanese Biopharmaceutical Consortium
Masato Kiyoshi, Hiroko Shibata, Akira Harazono, Tetsuo Torisu, Takahiro Maruno, Michiko Akimaru, Yuuka Asano, Mai Hirokawa, Keisuke Ikemoto, Yukari Itakura, Takafumi Iwura, Aya Kikitsu, Takashi Kumagai, Naoki Mori, Hiroaki Murase, Hirotaka Nishimura, Atsushi Oda, Taiichiro Ogawa, Takuma Ojima, Shinji Okabe, Shuntaro Saito, Satoshi Saitoh, Hiroyuki Suetomo, Kazuhiro Takegami, Momoko Takeuchi, Hidehito Yasukawa, Susumu Uchiyama, Akiko Ishii-Watabe
Journal of Pharmaceutical Sciences Vol. 108 No. 2 p. 832-841 2019/02 Research paper (scientific journal)
Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method
Akira Harazono, Hiroko Shibata, Masato Kiyoshi, Takashi Muto, Jun Fukuda, Tetsuo Torisu, Satoshi Saitoh, Hirotaka Nishimura, Susumu Uchiyama, Akiko Ishii-Watabe
Biologicals Vol. 57 p. 46-49 2019/01 Research paper (scientific journal)
Analysis of Higher Order Structure of Proteins by Hydrogen Deuterium Exchange Mass Spectrometry
Torisu Tetsuo
Journal of the Mass Spectrometry Society of Japan Vol. 66 No. 6 p. 218-221 2018/12 Research paper (scientific journal)
Publisher: The Mass Spectrometry Society of Japan
Recent Topics of Research in the Characterization and Quality Control of Biopharmaceuticals in Japan
Akiko Ishii-Watabe, Hiroko Shibata, Akira Harazono, Masashi Hyuga, Masato Kiyoshi, Satoshi Saitoh, Takafumi Iwura, Tetsuo Torisu, Yukihiro Goda, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 106 No. 12 p. 3431-3437 2017/12
Friability Testing as a New Stress-Stability Assay for Biopharmaceuticals
Tetsuo Torisu, Takahiro Maruno, Saki Yoneda, Yoshinori Hamaji, Shinya Honda, Tadayasu Ohkubo, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 106 No. 10 p. 2966-2978 2017/10 Research paper (scientific journal)
Synergistic Effect of Cavitation and Agitation on Protein Aggregation
Tetsuo Torisu, Takahiro Maruno, Yoshinori Hamaji, Tadayasu Ohkubo, Susumu Uchiyama
Journal of Pharmaceutical Sciences Vol. 106 No. 2 p. 521-529 2017/02/01 Research paper (scientific journal)
最新の知見・技術からみるバイオ医薬品の安定性/安定性に関わる分析・解析技術の最新概要
鳥巣哲生, 内山進
PHARM TECH JAPAN Vol. 41 No. 4 p. 43-47 2025/03
Quality and Physical Properties of Food Proteins
Mizuguchi Junya, Torisu Tetsuo, Uchiyama Susumu
Foods & Food Ingredients Journal of Japan Vol. 228 No. 2 p. 130-136 2023/04
Publisher: Editorial Board of Foods & Food Ingredients Journal of Japan
バイオ医薬品分析の新技術
鳥巣哲生
生物工学会誌 Vol. 99 No. 6 p. 295-297 2021/06
先端の分析法
澤田嗣郎
エヌ・ティー・エス 2022/01
ISBN: 9784860437374
創薬研究者がこれだけは知っておきたい最新のウイルス学
技術情報協会
技術情報協会 2021/08
ISBN: 9784861048555
バイオ医薬 : 基礎から開発まで
石井, 明子, 川西, 徹, 長野, 哲雄
東京化学同人 2020/03
ISBN: 9784807909810
タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで―
鳥巣哲生
シーエムシー出版 2019/02
医薬品原薬の結晶化と物性評価:その最先端技術と評価の実際
鳥巣哲生
シーエムシー出版 2019/01
タンパク質の面から見た泡沫の理解
鳥巣哲生
食品ハイドロコロイドシンポジウム 2025/06/21
振とうによる凝集傾向に基づく抗体の階層的クラスタリングと物理化学的パラメータとの関係
岡田梨櫻, 柴田耕生, 渋谷理紗, 鳥巣哲生, 内山進
第23回日本蛋白質科学会 2025/06/19
Investigation on aggregation of a therapeutic protein at interfaces using computational fluid dynamics
2025/03/27
Effect of tannic acid on foam properties of ovalbumin and its mechanism
2025/03/06
Physicochemical characterization and higher-order structural analysis of malt derived protein LTP1 during brewing process to improve beer foam quality
2025/03/06
振とうによる凝集傾向に基づく抗体の階層的クラスタリングと物理化学的パラメータとの関係
岡田梨櫻, 柴田耕生, 渋谷理紗, 鳥巣哲生, 内山進
第4回日本抗体学会設立記念学術大会
Structural analysis of human serum albumin and ovalbumin at a foam surface by hydrogen/deuterium exchange mass spectrometry
2024/08/30
Comprehensive prediction of antibody stability based on aggregation mechanism
卵白アルブミンとリゾチームの相互作用および構造と泡沫特性の解析
水口潤哉, 内山進, 鳥巣哲生
CIQuS 研究会/食品物性談話会 2024/07/24
水素/重水素交換質量分析を用いたヒト血清アルブミンおよび 卵白アルブミンの泡沫表面での構造解析
鳥巣哲生, 水口潤哉, 田之上凌佑, 榎本敢太, 内山進
CIQuS 研究会/食品物性談話会 2024/07/24
物理化学的パラメータを用いた抗体の合理的安定性予測法の開発
岡田梨櫻, 柴田耕生, 鳥巣哲生, 内山進
第24回日本蛋白質科学会年会
Relationship between genome release and capsid structural change of adeno-associated virus
下条咲希, 山口 祐希, 池田 智彦, ROCAFORT Mark Allen Vergara, 津中 康央, 福原 充子, 鳥巣 哲生, 内山 進
第24回日本蛋白質科学会年会
HDX-MS for probing structure of adeno-associated virus capsid
池田 智彦, 山口 祐希, 松下青葉, 津中康央, 福原充子, 鳥巣哲生, 内山進
第24回日本蛋白質科学会年会
A combination of lectin-based fractionation and LC-MS/MS for glycosylation analysis of recombinant adeno-associated virus
Yuki Yamaguchi, Kentaro Ishii, Sachiko Koizumi, Hiroaki Sakaue, Takahiro Maruno, Mitsuko Fukuhara, Risa Shibuya, Yasuo Tsunaka, Aoba Matsushita, Karin Bandoh, Tetsuo Torisu, Chie Murata-Kishimoto, Azusa Tomioka, Saho Mizukado, Hiroyuki Kaji, Yuji Kashiwakura, Tsukasa Ohmori, Atsushi Kuno, Susumu Uchiyama
ASMS 2024
Comparison of the Empty/Full ratio assessment by Direct Mass Technology, Analytical Ultracentrifugation and Mass Photometry for AAV vectors
Ryoji Nakatsuka, Yuki Yamaguchi, Aisu Tatsuya, Kiichi Hirohata, Saki Shimojo, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
ASMS 2024
Advanced Approach to the Purification and Characterization of AAV Vectors Based on Equilibrium Density Gradient Ultracentrifugation
Kiichi Hirohata, Yuki Yamaguchi, Takahiro Maruno, Takayuki Onishi, Tetsuo Torisu, Susumu Uchiyama
American Society of Gene and Cell Therapy 27th annual meeting
Development of image analysis methods to characterize the wider adeno-associated viral products using 100-keV cryo-electron microscopy
Haruka Nishiumi, Kiichi Hirohata, Mitsuko Fukuhara, Aoba Matsushita, Yasuo Tsunaka, Mark Allen Vergara Rocafor, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama
American Society of Gene and Cell Therapy 27th annual meeting
Mucin-type O-glycosylation in viral protein 2 indirectly affects the transduction efficiency of recombinant adeno-associated virus serotype 6.
Yuki Yamaguchi, Kentaro Ishii, Sachiko Koizumi, Hiroaki Sakaue, Takahiro Maruno, Mitsuko Fukuhara, Risa Shibuya, Yasuo Tsunaka, Aoba Matsushita, Karin Bandoh, Tetsuo Torisu, Chie Murata-Kishimoto, Azusa Tomioka, Saho Mizukado, Hiroyuki Kaji, Yuji Kashiwakura, Tsukasa Ohmori, Atsushi Kuno, Susumu Uchiyama
American Society of Gene and Cell Therapy 27th annual meeting
Quantification of Full and Empty Particles of Adeno-Associated Virus Vectors via a Novel Dual Fluorescence-Linked Immunosorbent Assay
Sereirath Soth, Mikako Takakura, Masahiro Suekawa, Takayuki Onishi, Takahiro Maruno, Mitsuko Fukuhara, Yasuo Tsunaka, Tetsuo Torisu, Susumu Uchiyama
American Society of Gene and Cell Therapy 27th annual meeting 2024/05/08
HDX-MS for probing structure of adeno- associated virus capsid
Tomohiko Ikeda, Yuki Yamaguchi, Mitsuko Fukuhara, Yasuo Tsunaka, Aoba Matsushita, Tetsuo Torisu, Susumu Uchiyama
4th international conference of hydrogen deuterium exchange mass spectrometry 2024/04/22
Structural analysis of human serum albumin at a foam surface by hydrogen/deuterium exchange mass spectrometry
Tetsuo Torisu, Kanta Enomoto, Junya Mizuguchi, Ryosuke Tanoue, Susumu Uchiyama
2024/04/22
Protein aggregation induced by combination of thermal and agitation
ZEKUN WANG, Tetsuo Torisu, Susumu Uchiyama
The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024/03/30
Protein aggregation induced by dropping in frozen state
Tetsuo Torisu, Ayuko Maeda, Susumu Uchiyama
The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024/03/31
Analysis of interaction and structure of egg white albumin and lysozyme with foam properties
Tetsuo TORISU, Junya MIZUGUCHI
2024/03/26
Structural analysis of human serum albumin at a foam surface by hydrogen/deuterium exchange mass spectrometry
Tetsuo TORISU, Kanta ENOMOTO, Junya MIZUGUCHI, Ryosuke TANOUE, Susumu UCHIYAMA
2024/03/26
Characterization of adeno-associated virus genome release by mass photometry
Saki Shimojo, Yuki Yamaguchi, Tomohiko Ikeda, Tetsuo Torisu, Yasuo Tsunaka, Mitsuko Fukuhara, Susumu Uchiyama
界面でのタンパク質の構造と凝集について
鳥巣哲生
バイオインタラクション研究会第22回ワークショップ 2023/09/15
Comprehensive evaluation of particle components in adeno-associated virus vector samples
Takahiro Maruno, Takaaki Kurinomaru, Masanori Noda, Mitsuko Fukuhara, Kiichi Hirohata, Yasuo Tsunaka, Yuki Yamaguchi, Tetsuo Torisu, Susumu Uchiyama
第29回日本遺伝子細胞治療学会(JSGCT2023) 2023/09/12
Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly
Takayuki Onishi, Michika Nonaka, Takahiro Maruno, Yuki Yamaguchi, Mitsuko Fukuhara, Tetsuo Torisu, Noriko Yamano-Adachi, Takeshi Omasa, Susumu Uchiyama
第29回日本遺伝子細胞治療学会(JSGCT2023) 2023/09/12
Quantification of full and empty particles of Adeno-Associated Virus vectors by a novel Dual Fluorescence-Linked Immunosorbent Assay (dFLISA)
Sereirath Soth, TORISU Tetsuo, UCHIYAM Susumu
第29回日本遺伝子細胞治療学会(JSGCT2023) 2023/09/12
HDX-MS and XL-MS analyses of antigen^IgG-FcgammaRIIIa interactions
山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進
71st ASMS Conference 2023/06
質量によるバイオ医薬品のタンパク質の特性解析
山口祐希, 下条咲希, 池田智彦, 鳥巣哲生, 内山進
第71回日本質量分析総合討論会 2023/05
Small volume analytical ultracentrifugation of AAV vectors based on the band sedimentation velocity method
Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama
26th American Society of Gene & Cell Therapy Annual Meeting (Molecular therapy) 2023/05
抗体の Fab 領域が担う抗原-抗体-Fc 受容体の相互作用に対する役 割の解明
山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進
第１回 日本抗体学会 2022/11
ハイスループットな抗体の吸着量定量方法の開発
岡田梨櫻, 柴田耕生, 米田早紀, 鳥巣哲生, 内山進
第１回 日本抗体学会 2022/11
Comprehensive particle characterization of adeno-associated virus vector by multiwavelength sedimentation velocity analytical ultracentrifugation
Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama
14th International Oncolytic Virotherapy Conference 2022 2022/10
抗体と抗原および Fc受容体の相互作用の速度論的および構造生物学的解析
山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進
⽇本プロテオーム学会 2022 年⼤会 2022/08
水素/重水素交換質量分析とクロスリンク質量分析を用いたFcγRIIIaおよび抗原との結合におけるIgGの構造解析
山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進
第７０回 質量分析総合討論会 2022/06
Comprehensive particle characterization of adeno-associated virus vector by analytical ultracentrifugation
Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama
25th American Society of Gene & Cell Therapy Annual Meeting (Molecular Therapy) 2022/04
Influence of protein adsorption on aggregation in pre-filled syringes
Saki Yoneda, Takahiro Maruno, Asuka Mori, Ayana Hioki, Haruka Nishiumi, Rio Okada, Makoto Murakami, Wang Zekun, Ayano Fukuhara, Nozomi Itagaki, Yosuke Harauchi, Satoru Adachi, Kumi Okuyama, Taichi Sawaguchi, Tetsuo Torisu, Susumu Uchiyama
2021/12
バイオ医薬品の凝集体抑制のためのタンパク質の容器内への吸着メカニズム解析
米田早紀, 丸野孝浩, 森飛鳥, 日置彩那, 西海遥夏, 岡田梨櫻, Wang Zekun, 村上誠, 福原彩乃, 板垣望, 原内洋輔, 足立慧, 奥山久美, 澤口太一, 鳥巣哲生, 内山進
第21回蛋白質科学会年会 2021/06/17
Utility of three flow imaging microscopies for image analysis to evaluate four types of subvisible particle in biopharmaceuticals
Haruka Nishiumi, Natalie Deiringer, Nils Krause, Saki Yoneda, Tetsuo Torisu, Tim Menzen, Wolfgang Friess, Susumu Uchiyama
2021/06/14
水素/重水素交換質量分析法を用いた気液界面における治療用タンパク質の構造解析
榎本 敢太, 鳥巣 哲生, 内山 進
日本薬学会第141年会 2021/03/27
Structural analysis of a therapeutic protein at air-liquid interface
榎本敢太, 鳥巣哲生, 内山進
第 20 回日本蛋白質科学会年会 2020/07
Stability and structural changes of an antibody in different buffers
Oyama H, ○Enomoto K, Torisu T, Uchiyama S
2019/05
IgGとFc受容体の相互作用におけるFab領域の新規結合部位の同定
與語理那, 與語理那, 山口祐希, 渡辺大輝, 矢木宏和, 佐藤匡史, 中西真人, 鬼塚正義, 大政健史, 嶋田麻里, 丸野孝浩, 鳥巣哲生, 渡邊史生, 肥後大輔, 内橋貴之, 内橋貴之, 谷中冴子, 谷中冴子, 内山進, 内山進, 加藤晃一, 加藤晃一
日本生化学会大会(Web) 2019
HDX-MSによる抗体とFc受容体の相互作用解析
山口祐希, 與語理那, 與語理那, 矢木宏和, 佐藤匡史, 中西真人, 嶋田麻里, 丸野孝浩, 鳥巣哲生, 渡邊史生, 肥後大輔, 谷中冴子, 谷中冴子, 加藤晃一, 加藤晃一, 内山進, 内山進
日本分子生物学会年会 2019
IgG1,IgG1-FabおよびIgG1-FcのHDX-MSによる構造解析
若泉なつみ, 山口祐希, 鳥巣哲生, 内山進, 内山進
日本分子生物学会年会 2019
様々な物理化学的分析を活用したバイオ医薬品・ワクチンの開発
鳥巣哲生
日本動物細胞工学会シンポジウム39 2018/06/15
バイオ医薬品のタンパク質微粒子評価のための多機関共同測定による光遮蔽法とフローイメージング法の比較
原園景, 柴田寛子, 木吉真人, 鳥巣哲生, 板倉由佳里, 古木健一朗, 福田潤, 末友裕行, 山崎勝由, 大庭澄明, 小島昌太, 西村仁孝, 中家修一, 前田裕貴, 内山進, 横山雅美, クラユヒナ エレナ, 石井明子
日本薬学会年会 2018
投与時までの安定性を考慮したバイオ医薬品の品質評価
鳥巣哲生, 丸野孝浩, 米田早紀, 浜地芳典, 本田真也, 大久保忠恭, 内山進, 内山進
日本薬学会年会 2018
バイオ医薬品の不溶性微粒子試験改良のための検討:試験の容量及び測定粒子径範囲
原園景, 鳥巣哲生, 寺島勇, 齋藤智, 水野保子, 岡野清, 大庭澄明, 柳原繁弘, 福田潤, 山口秀人, 古木健一郎, 中家修一, 鷲尾一裕, 古賀淳一, 小林直樹, 齋藤俊太郎, 横山毅, 内山進, 横山雅美, KRAYUKHINA Elena, 中野祥晃, 安川秀仁, 辰巳正史, 中子真由美, 田中二郎, 木吉真人, 石井明子
日本薬学会年会 2016
Use of cesium chloride density gradient ultracentrifugation for the purification and characterization of recombinant adeno-associated virus
Hirohata Kiichi, Kino Shinichiro, Yamane Takuya, Bandoh Karin, Bamba Takeshi, Sternisha Shawn M., Torisu Tetsuo, Fukuhara Mitsuko, Yamaguchi Yuki, Uchiyama Susumu
European Biophysics Journal 2025/05/19
Protein aggregation in the frozen state induced by dropping stress
Torisu Tetsuo, Maeda Ayuko, Ito Shuhei, Uchiyama Susumu
European Journal of Pharmaceutical Sciences Vol. 205 2025/02/01
Prediction models for the flux decay profile and initial flux of microfiltration for therapeutic proteins
Inoue Kota, Masuda Yumiko, Torisu Tetsuo, Nonaka Koichi, Uchiyama Susumu
Biotechnology and Bioengineering Vol. 121 No. 6 p. 1889-1901 2024/06/01
Structure of Human Serum Albumin at a Foam Surface
Enomoto Kanta, Torisu Tetsuo, Mizuguchi Junya, Tanoue Ryosuke, Uchiyama Susumu
Journal of Agricultural and Food Chemistry Vol. 72 No. 15 p. 8774-8783 2024/04/17
落下・振とう複合ストレスによるバイオ医薬品の凝集に関する研究
鳥巢 哲生
