Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism

Yasuharu Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin Sun, Daisuke Motooka, Shota Nakamura, Hiroki Tanaka, Takashi Satoh, Kazuhiko Maeda, Shizuo Akira

Proceedings of the National Academy of Sciences　Vol. 115　No. 43　p. 11036-11041　2018/10/23　Research paper (scientific journal)

BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation

Hisashi Kanemaru, Fumihiro Yamane, Hiroki Tanaka, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira

International Immunology　Vol. 30　No. 6　p. 255-265　2018/05/24　Research paper (scientific journal)

Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages

Hisashi Kanemaru, Fumihiro Yamane, Kiyoharu Fukushima, Takanori Matsuki, Takahiro Kawasaki, Isao Ebina, Kanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira

Proceedings of the National Academy of Sciences　Vol. 114　No. 35　p. E7331-E7340　2017/08/29　Research paper (scientific journal)

Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members

Phuong Pham, Samir A. Afif, Mayuko Shimoda, Kazuhiko Maeda, Nobuo Sakaguchi, Lars C. Pedersen, Myron F. Goodman

DNA Repair　Vol. 54　p. 8-12　2017/06　Research paper (scientific journal)

Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells

Mohammed Mansour Abbas Eid, Mayuko Shimoda, Shailendra Kumar Singh, Sarah Ameen Almofty, Phuong Pham, Myron F. Goodman, Kazuhiko Maeda, Nobuo Sakaguchi

International Immunology　Vol. 29　No. 5　p. 211-220　2017/05/01　Research paper (scientific journal)

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity.

Terumasa Ikeda, Mayuko Shimoda, Diako Ebrahimi, John L VandeBerg, Reuben S Harris, Atsushi Koito, Kazuhiko Maeda

Scientific Reports　Vol. 7　No. 1　p. 46719-46719　2017/04/21　Research paper (scientific journal)

Introduction: Dynamics of RNA Regulation in the Immune System Special Issue

Shizuo Akira, Kazuhiko Maeda

International Immunology　Vol. 29　No. 4　p. 145-147　2017/04　Research paper (scientific journal)

Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells

Kazuhiko Maeda, Shizuo Akira

International Immunology　Vol. 29　No. 4　p. 149-155　2017/04/01　Research paper (scientific journal)

TLR7 Structure: Cut in Z-Loop

Kazuhiko Maeda, Shizuo Akira

Immunity　Vol. 45　No. 4　p. 705-707　2016/10　Research paper (scientific journal)

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

Phuong Pham, Samir A. Afif, Mayuko Shimoda, Kazuhiko Maeda, Nobuo Sakaguchi, Lars C. Pedersen, Myron F. Goodman

DNA Repair　Vol. 43　p. 48-56　2016/07　Research paper (scientific journal)

Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities

Terumasa Ikeda, Eugene Boon Beng Ong, Nobumoto Watanabe, Nobuo Sakaguchi, Kazuhiko Maeda, Atsushi Koito

Scientific Reports　Vol. 6　No. 1　2016/05　Research paper (scientific journal)

Germinal Center B-Cell-Associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell Maturation

N. Sakaguchi, K. Maeda

Advances in Immunology　p. 135-186　2016　Part of collection (book)

GANP Regulates the Choice of DNA Repair Pathway by DNA-PKcs Interaction in AID-DependentIgVRegion Diversification

Mohammed Mansour Abbas Eid, Kazuhiko Maeda, Sarah Ameen Almofty, Shailendra Kumar Singh, Mayuko Shimoda, Nobuo Sakaguchi

The Journal of Immunology　Vol. 192　No. 12　p. 5529-5539　2014/06/15　Research paper (scientific journal)

GANP Interacts with APOBEC3G and Facilitates Its Encapsidation into the Virions To Reduce HIV-1 Infectivity

Kazuhiko Maeda, Sarah Ameen Almofty, Shailendra Kumar Singh, Mohammed Mansour Abbas Eid, Mayuko Shimoda, Terumasa Ikeda, Atsushi Koito, Phuong Pham, Myron F. Goodman, Nobuo Sakaguchi

The Journal of Immunology　Vol. 191　No. 12　p. 6030-6039　2013/12/15　Research paper (scientific journal)

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy

Shailendra Kumar Singh, Kazuhiko Maeda, Mohammed Mansour Abbas Eid, Sarah Ameen Almofty, Masaya Ono, Phuong Pham, Myron F. Goodman, Nobuo Sakaguchi

Nature Communications　Vol. 4　No. 1　2013/06　Research paper (scientific journal)

Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4

Teppei Toda, Kazuhiko Kuwahara, Naoyuki Kondo, Zene Matsuda, Yosuke Maeda, Kazuhiko Maeda, Nobuo Sakaguchi

Immunobiology　Vol. 217　No. 9　p. 864-872　2012/09　Research paper (scientific journal)

Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons

Terumasa Ikeda, Khaled Hussein Abd El Galil, Kenzo Tokunaga, Kazuhiko Maeda, Tetsutaro Sata, Nobuo Sakaguchi, Thierry Heidmann, Atsushi Koito

Nucleic Acids Research　Vol. 39　No. 13　p. 5538-5554　2011/07　Research paper (scientific journal)

Molecular Mechanism of Immunoglobulin V-Region Diversification Regulated by Transcription and RNA Metabolism in Antigen-Driven B Cells

N. Sakaguchi, K. Maeda, K. Kuwahara

SCANDINAVIAN JOURNAL OF IMMUNOLOGY　Vol. 73　No. 6　p. 520-526　2011/06　Research paper (scientific journal)

GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA

Kazuhiko Maeda, Shailendra Kumar Singh, Kazufumi Eda, Masahiro Kitabatake, Phuong Pham, Myron F. Goodman, Nobuo Sakaguchi

Journal of Biological Chemistry　Vol. 285　No. 31　p. 23945-23953　2010/07/30　Research paper (scientific journal)

Generation of High Affinity Monoclonal Antibodies for the Prevention of HIV Infection

Nobuo Sakaguchi, Teppei Toda, Teruo Nakaya, Masataka Kitabatake, Kazuhiko Maeda, Kazuhiko Kuwahara

Recent Patents on DNA & Gene Sequences　Vol. 3　No. 2　p. 88-95　2009/06/01　Research paper (scientific journal)

GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells

Hideya Igarashi, Kazuhiko Kuwahara, Mikoto Yoshida, Yan Xing, Kazuhiko Maeda, Koichi Nakajima, Nobuo Sakaguchi

Molecular Immunology　Vol. 46　No. 6　p. 1031-1041　2009/03　Research paper (scientific journal)

Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene

Satoru Fujimura, Takeshi Matsui, Kazuhiko Kuwahara, Kazuhiko Maeda, Nobuo Sakaguchi

Molecular Immunology　Vol. 45　No. 6　p. 1712-1719　2008/03　Research paper (scientific journal)

Regulation of CaMKII by α4/PP2Ac contributes to learning and memory

Takeshi Yamashita, Seiji Inui, Kazuhiko Maeda, Ding Rong Hua, Katsumasa Takagi, Kohji Fukunaga, Nobuo Sakaguchi

Brain Research　Vol. 1082　No. 1　p. 1-10　2006/04/12　Research paper (scientific journal)

IL-6 blocks a discrete early step in lymphopoiesis

Kazuhiko Maeda, Yoshihiro Baba, Yoshinori Nagai, Kozo Miyazaki, Alexander Malykhin, Koji Nakamura, Paul W. Kincade, Nobuo Sakaguchi, K. Mark Coggeshall

Blood　Vol. 106　No. 3　p. 879-885　2005/08/01　Research paper (scientific journal)

The heterodimer of α4 and PP2Ac is associated with S6 kinase1 in B cells

Takeshi Yamashita, Seiji Inui, Kazuhiko Maeda, Ding Rong Hua, Katsumasa Takagi, Nobuo Sakaguchi

Biochemical and Biophysical Research Communications　Vol. 330　No. 2　p. 439-445　2005/05　Research paper (scientific journal)

Src Homology 2–containing 5-Inositol Phosphatase (SHIP) Suppresses an Early Stage of Lymphoid Cell Development through Elevated Interleukin-6 Production by Myeloid Cells in Bone Marrow

Koji Nakamura, Taku Kouro, Paul W. Kincade, Alexander Malykhin, Kazuhiko Maeda, K. Mark Coggeshall

Journal of Experimental Medicine　Vol. 199　No. 2　p. 243-254　2004/01/19　Research paper (scientific journal)

T cell-specific gene targeting reveals that α4 is required for early T cell development

Ding Rong Hua, Seiji Inui, Takeshi Yamashita, Kazuhiko Maeda, Katsumasa Takagi, Junji Takeda, Nobuo Sakaguchi

European Journal of Immunology　Vol. 33　No. 7　p. 1899-1906　2003/07　Research paper (scientific journal)

MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR

Yoshihiko Kono, Kazuhiko Maeda, Kazuhiko Kuwahara, Hideyuki Yamamoto, Eishichi Miyamoto, Kazuyoshi Yonezawa, Katsumasa Takagi, Nobuo Sakaguchi

Genes to Cells　Vol. 7　No. 8　p. 821-834　2002/08/07　Research paper (scientific journal)

BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation

Seiji Inui, Kazuhiko Maeda, Ding Rong Hua, Takeshi Yamashita, Hideyuki Yamamoto, Eishichi Miyamoto, Shinichi Aizawa, Nobuo Sakaguchi

International Immunology　Vol. 14　No. 2　p. 177-187　2002/02　Research paper (scientific journal)

PU.1 Is Involved in the Regulation of B Lineage-associated and Developmental Stage-dependent Expression of the Germinal Center-associated DNA Primase GANP

Mohamed A. EL-Gazzar, Kazuhiko Maeda, Hisayuki Nomiyama, Mitsuyoshi Nakao, Kazuhiko Kuwahara, Nobuo Sakaguchi

Journal of Biological Chemistry　Vol. 276　No. 51　p. 48000-48008　2001/12/21　Research paper (scientific journal)

A new member of the alpha4-related molecule (alpha4-b) that binds to the protein phosphatase 2A is expressed selectively in the brain and testis

Kazuhiko Maeda, Seiji Inui, Hideaki Tanaka, Nobuo Sakaguchi

European Journal of Biochemistry　Vol. 264　No. 3　p. 702-706　1999/09/25　Research paper (scientific journal)

Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A

Seiji Inui, Hideki Sanjo, Kazuhiko Maeda, Hideyuki Yamamoto, Eisshichi Miyamoto, Nobuo Sakaguchi

Blood　Vol. 92　No. 2　p. 539-546　1998/07　Research paper (scientific journal)

The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule α4 that is related to the yeast TAP42 involved in a rapamycin-sensitive pathway

Kazuhiko Maeda, Seiji Inui, Hideki Sanjo, Nobuo Sakaguchi

Gene　Vol. 210　No. 2　p. 287-295　1998/04　Research paper (scientific journal)

Expression and Chromosomal Localization of the Human α4/IGBP1 Gene, the Structure of Which Is Closely Related to the Yeast TAP42 Protein of the Rapamycin-Sensitive Signal Transduction Pathway

Mitsugi Onda, Seiji Inui, Kazuhiko Maeda, Mikio Suzuki, Ei-ichi Takahashi, Nobuo Sakaguchi

Genomics　Vol. 46　No. 3　p. 373-378　1997/12　Research paper (scientific journal)

Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction

Seiji Inui, Kazuhiko Kuwahara, Jyunichi Mizutani, Kazuhiko Maeda, Taro Kawai, Hiroyuki Nakayasu, Nobuo Sakaguchi

Vol. 154　No. 6　p. 2714-2723　1995/03/15　Research paper (scientific journal)

Anti-CD40 monoclonal antibody induces the proliferation of murine B cells as a B-cell mitogen through a distinct pathway from receptors for antigens or lipopolysaccharide

Jun Nomura, Seiji Inui, Tsunenobu Yamasaki, Satosi Kataoka, Kazuhiko Maeda, Kenji Nakanishi, Nobuo Sakaguchi

Immunology Letters　Vol. 45　No. 3　p. 195-203　1995/03/01　Research paper (scientific journal)