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Noriyuki Tsumaki

妻木 範行

Graduate School of Frontier Biosciences　Department of Frontier Biosciences, Professor

keyword Regenerative medicine，軟骨代謝

Education

  • 1992/04 - 1996/03, 大阪大学大学院, 医学研究科博士課程
  • - 1996, Osaka University, Graduate School, Division of Medicine
  • 1983/04 - 1989/03, Osaka University, Faculty of Medicine, Medical School

Research History

  • 2021/07 - Present, Graduate School of Medicine, Osaka University, Department of Biochemistry and Molecular Biology, Professor
  • 2011/06 - Present, Kyoto University
  • 2007/04 - 2011/05, Osaka University Graduate School of Medicine
  • 2002/08 - 2007/03, 大阪大学大学院, 医学系研究科 整形外科, 助手
  • 1999/04 - 2002/07, 大阪警察病院, 整形外科, 副医長
  • 1998/01 - 1999/03, Osaka University, Faculty of Medicine
  • 1996/06 - 1998/01, 米国国立保健研究所（NIH), Visiting fellow
  • 1996/04 - 1996/05, Osaka University, Faculty of Medicine
  • 1989/05 - 1992/03, Osaka University, Hospital

Research Areas

  • Life sciences, Functional biochemistry

Professional Memberships

  • The American Society for Bone and Mineral Research
  • 米国骨代謝学会
  • 日本結合組織学会
  • 日本軟骨代謝学会
  • 日本骨代謝学会
  • 日本リウマチ学会
  • 日本整形外科学会
  • The American Society for Bone and Mineral Research

Papers

  • Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles, Shinichi Nakagawa,Wataru Ando,Kazunori Shimomura,David A. Hart,Hiroto Hanai,George Jacob,Ryota Chijimatsu,Seido Yarimitu,Hiromichi Fujie,Seiji Okada,Noriyuki Tsumaki,Norimasa Nakamura, npj Regenerative Medicine, Springer Science and Business Media LLC, Vol. 8, No. 1, 2023/10/19
  • Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone, Hiroki Hagizawa,Saeko Koyamatsu,Seiji Okada,Takashi Kaito,Noriyuki Tsumaki, Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 11, 2023/05/15
  • Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect, Kengo Abe,Akihiro Yamashita,Miho Morioka,Nanao Horike,Yoshiaki Takei,Saeko Koyamatsu,Keisuke Okita,Shuichi Matsuda,Noriyuki Tsumaki, Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1, 2023/02/20
  • 低血清および低酸素条件下におけるiPS細胞由来軟骨細胞シートの硝子軟骨修復能の向上, 内山 綾香,佐藤 正人,高橋 匠,豊田 恵利子,前原 美樹,大村 はるか,小川 真梨奈,森岡 美帆,山下 晃弘,渡辺 雅彦,妻木 範行, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 96, No. 8, p. S1556-S1556, 2022/09
  • Universal Surface Biotinylation: a simple, versatile and cost-effective sample multiplexing method for single-cell RNA-seq analysis, Michihiko Sugimoto,Yuhki Tada,Shigeyuki Shichino,Saeko Koyamatsu,Noriyuki Tsumaki,Kuniya Abe, DNA Research, Oxford University Press (OUP), Vol. 29, No. 3, 2022/05/27
  • Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus, Takashi Kamatani,Hiroki Hagizawa,Seido Yarimitsu,Miho Morioka,Saeko Koyamatsu,Michihiko Sugimoto,Joe Kodama,Junko Yamane,Hiroyuki Ishiguro,Shigeyuki Shichino,Kuniya Abe,Wataru Fujibuchi,Hiromichi Fujie,Takashi Kaito,Noriyuki Tsumaki, Biomaterials, Elsevier BV, Vol. 284, p. 121491-121491, 2022/05
  • Generation of monkey iPS cell-derived cartilage lacking MHC class I molecules on the cell surface, Okutani, Yuki,Abe, Kengo,Yamashita, Akihiro,Morioka, Miho,Matsuda, Shuichi,Tsumaki, Noriyuki, Tissue Engineering Part A, Vol. 28, No. 1-2, p. 94-106, 2022/01
  • Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects, Wai Long Tam,Luís Freitas Mendes,Xike Chen,Raphaëlle Lesage,Inge Van Hoven,Elke Leysen,Greet Kerckhofs,Kathleen Bosmans,Yoke Chin Chai,Akihiro Yamashita,Noriyuki Tsumaki,Liesbet Geris,Scott J. Roberts,Frank P. Luyten, Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 12, No. 1, 2021/12
  • Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice., Yuki Iimori,Miho Morioka,Saeko Koyamatsu,Noriyuki Tsumaki, Tissue engineering. Part A, Vol. 27, No. 21-22, p. 1355-1367, 2021/08/16
  • Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells, Akihiro Yamashita,Noriyuki Tsumaki, Development, Growth & Differentiation, Wiley, Vol. 63, No. 1, p. 72-81, 2021/01
  • Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells., Akihiro Yamashita,Hiroyuki Yoshitomi,Shunsuke Kihara,Junya Toguchida,Noriyuki Tsumaki, Stem cells translational medicine, Vol. 10, No. 1, p. 115-127, 2021/01
  • Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia., Tomonori Ozaki,Tatsuya Kawamoto,Yuki Iimori,Nobuaki Takeshita,Yukiko Yamagishi,Hiroaki Nakamura,Masazumi Kamohara,Kaori Fujita,Masayuki Tanahashi,Noriyuki Tsumaki, Scientific reports, Vol. 10, No. 1, p. 20915-20915, 2020/12/01
  • Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage, Yoshiaki Takei,Miho Morioka,Akihiro Yamashita,Tomohito Kobayashi,Nobuyuki Shima,Noriyuki Tsumaki, Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1, 2020/07/30
  • Visualization of human iPS cells-derived 3D cartilage tissue by gelatin nanospheres., Yuki Murata,Jun-Ichiro Jo,Hiroshi Yukawa,Noriyuki Tsumaki,Yoshinobu Baba,Yasuhiko Tabata, Tissue engineering. Part C, Methods, Vol. 26, No. 5, p. 244-252, 2020/03/06
  • Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation., Kosai A,Horike N,Takei Y,Yamashita A,Fujita K,Kamatani T,Tsumaki N, Biochem Biophys Res Commun., Vol. 516, No. 4, p. 1097-1102, 2019/09
  • 量子ドット・磁性ナノ粒子含有ゼラチンナノ粒子を用いたヒトiPS細胞由来3次元軟骨組織の可視化, 城 潤一郎,村田 勇樹,湯川 博,妻木 範行,馬場 嘉信,田畑 泰彦, JSMI Report, 日本分子イメージング学会, Vol. 12, No. 2, p. 123-123, 2019/05
  • Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia, Kimura T,Ozaki T,Fujita K,Yamashita A,Morioka M,Ozono K,Tsumaki N, Osteoarthritis and Cartilage, Vol. 26, No. 11, p. 1551-1561, 2018/11
  • Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage., Chen X,Yamashita A,Morioka M,Senba T,Kamatani T,Watanabe A,Kosai A,Tsumaki N, Tissue engineering. Part A, Vol. 25, No. 5-6, p. 437-445, 2018/10
  • 椎間板変性および椎間板関連の疼痛に対する選択的c-Fos/AP-1阻害の治療効果, 牧野 紘士,関 庄二,箭原 康人,塩沢 俊一,妻木 範行,木村 友厚, 中部日本整形外科災害外科学会雑誌, (一社)中部日本整形外科災害外科学会, Vol. 61, No. 秋季学会, p. 261-261, 2018/09
  • 運動器疾患に対するiPS細胞研究の進歩 関節軟骨欠損に対するiPS細胞由来軟骨を用いた治療について, 小林 与人,武井 義明,山下 晃弘,森岡 美帆,釜谷 崇志,高才 東,Woltjen Knut,松田 秀一,妻木 範行, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 92, No. 8, p. S1938-S1938, 2018/08
  • 骨代謝と病気の新たなクロストーク:臓器連関から創薬まで 疾患特異的ヒトiPS細胞を用いた成長板軟骨モデルの確立と創薬への応用, 木村 武司,尾崎 友則,藤田 香里,山下 晃弘,森岡 美穂,大薗 恵一,妻木 範行, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 36回, p. 115-115, 2018/07
  • 【腰痛治療の革新-慢性腰痛・神経障害性疼痛に対する治療のbreakthrough】椎間板変性抑制と椎間板再生を目指した治療標的因子, 関 庄二,牧野 紘士,箭原 康人,塩沢 俊一,妻木 範行,木村 友厚, Journal of Spine Research, (一社)日本脊椎脊髄病学会, Vol. 9, No. 6, p. 1017-1021, 2018/06
  • Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9., Hiroki Goto,Miki Nishio,Yoko To,Tatsuya Oishi,Yosuke Miyachi,Tomohiko Maehama,Hiroshi Nishina,Haruhiko Akiyama,Tak Wah Mak,Yuma Makii,Taku Saito,Akihiro Yasoda,Noriyuki Tsumaki,Akira Suzuki, Development (Cambridge, England), Vol. 145, No. 6, 2018/03/16
  • A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation, Tomohito Kobayashi,Kaori Fujita,Takashi Kamatani,Shuichi Matsuda,Noriyuki Tsumaki, Biochemical and Biophysical Research Communications, Elsevier B.V., Vol. 495, No. 1, p. 1468-1475, 2018/01/01
  • Considerations in hiPSC-derived cartilage for articular cartilage repair., Yamashita A,Tamamura Y,Morioka M,Karagiannis P,Shima N,Tsumaki N, Inflammation and regeneration, Vol. 38, p. 17-17, 2018
  • A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain, Hiroto Makino,Shoji Seki,Yasuhito Yahara,Shunichi Shiozawa,Yukihiko Aikawa,Hiraku Motomura,Makiko Nogami,Kenta Watanabe,Takeshi Sainoh,Hisakatsu Ito,Noriyuki Tsumaki,Yoshiharu Kawaguchi,Mitsuaki Yamazaki,Tomoatsu Kimura, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/12
  • Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages, Takeshi Kimura,Akihiro Yamashita,Keiichi Ozono,Noriyuki Tsumaki, TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, Vol. 22, No. 23-24, p. 1367-1375, 2016/12
  • 軟骨細胞特異的なSik3の欠失は関節軟骨の厚みを増大させる, 箭原 康人,竹森 洋,岡田 稔,高才 東,山下 晃弘,小林 与人,藤田 香里,伊東 裕美,中村 正裕,渕野 裕之,川原 信夫,福井 尚志,渡辺 亮,木村 友厚,妻木 範行, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 90, No. 8, p. S1487-S1487, 2016/08
  • Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3, Yasuhito Yahara,Hiroshi Takemori,Minoru Okada,Azuma Kosai,Akihiro Yamashita,Tomohito Kobayashi,Kaori Fujita,Yumi Itoh,Masahiro Nakamura,Hiroyuki Fuchino,Nobuo Kawahara,Naoshi Fukui,Akira Watanabe,Tomoatsu Kimura,Noriyuki Tsumaki, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 7, 2016/03
  • iPS細胞を用いた軟骨疾患に対する再生医療開発, 山下晃弘,妻木範行, 月刊糖尿病, Vol. 8, No. 6, p. 91-97, 2016
  • 椎間板変性メカニズムと再生への架け橋 椎間板変性抑制を目指した治療標的因子, 関 庄二,牧野 紘士,箭原 康人,元村 拓,野上 真紀子,渡邉 健太,塩沢 俊一,淺沼 由美子,舛田 浩一,妻木 範行,木村 友厚, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 89, No. 8, p. S1522-S1522, 2015/09
  • 変形性関節症性変化におけるSik3の役割, 箭原 康人,木村 友厚,妻木 範行, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 89, No. 8, p. S1712-S1712, 2015/09
  • 選択的c-Fos/AP-1阻害薬によるマウスの椎間板変性抑制効果, 箭原 康人,関 庄二,牧野 紘士,塩沢 俊一,妻木 範行,木村 友厚, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 89, No. 8, p. S1782-S1782, 2015/09
  • Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes, Yumi Itoh,Masato Sanosaka,Hiroyuki Fuchino,Yasuhito Yahara,Ayako Kumagai,Daisaku Takemoto,Mai Kagawa,Junko Doi,Miho Ohta,Noriyuki Tsumaki,Nobuo Kawahara,Hiroshi Takemori, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 29, p. 17879-17893, 2015/07
  • Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs, Akihiro Yamashita,Miho Morioka,Yasuhito Yahara,Minoru Okada,Tomohito Kobayashi,Shinichi Kuriyama,Shuichi Matsuda,Noriyuki Tsumaki, STEM CELL REPORTS, CELL PRESS, Vol. 4, No. 3, p. 404-418, 2015/03
  • 小児疾患の新規治療開発ーiPS細胞の有用性, 妻木範行,山下晃弘,岡田稔, 骨と腎代謝, Vol. 28, No. 3, p. 241-247, 2015
  • ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成, 山下晃弘,妻木範行, 日本再生医療学会, Vol. 14, No. 4, p. 70-74, 2015
  • iPS cell technologies and cartilage regeneration, Noriyuki Tsumaki,Minoru Okada,Akihiro Yamashita, BONE, ELSEVIER SCIENCE INC, Vol. 70, p. 48-54, 2015/01
  • Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells, Minoru Okada,Shiro Ikegawa,Miho Morioka,Akihiro Yamashita,Atsushi Saito,Hideaki Sawai,Jun Murotsuki,Hirofumi Ohashi,Toshio Okamoto,Gen Nishimura,Kazunori Imaizumi,Noriyuki Tsumaki, HUMAN MOLECULAR GENETICS, OXFORD UNIV PRESS, Vol. 24, No. 2, p. 299-313, 2015/01
  • Cell reprogramming for skeletal dysplasia drug repositioning, Peter Karagiannis,Noriyuki Tsumaki, CELL CYCLE, LANDES BIOSCIENCE, Vol. 13, No. 24, p. 3791-3792, 2014/12
  • Cyp26b1 within the growth plate regulates bone growth in juvenile mice, Yoshiki Minegishi,Yasuo Sakai,Yasuhito Yahara,Haruhiko Akiyama,Hideki Yoshikawa,Ko Hosokawa,Noriyuki Tsumaki, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 454, No. 1, p. 12-18, 2014/11
  • Statin treatment rescues FGFR3 skeletal dysplasia phenotypes, Akihiro Yamashita,Miho Morioka,Hiromi Kishi,Takeshi Kimura,Yasuhito Yahara,Minoru Okada,Kaori Fujita,Hideaki Sawai,Shiro Ikegawa,Noriyuki Tsumaki, NATURE, NATURE PUBLISHING GROUP, Vol. 513, No. 7519, p. 507-+, 2014/09
  • マウスOAモデルにおける関節軟骨細胞分化の解析, 箭原 康人,木村 友厚,妻木 範行, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 88, No. 8, p. S1423-S1423, 2014/08
  • Cartilage intermediate layer protein promotes lumbar disc degeneration, Shoji Seki,Noriyuki Tsumaki,Hiraku Motomura,Makiko Nogami,Yoshiharu Kawaguchi,Takeshi Hori,Kayo Suzuki,Yasuhito Yahara,Mami Higashimoto,Takeshi Oya,Shiro Ikegawa,Tomoatsu Kimura, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 446, No. 4, p. 876-881, 2014/04/18
  • Sox9 Reprogrammed Dermal Fibroblasts Undergo Hypertrophic Differentiation In Vitro and Trigger Endochondral Ossification In Vivo, Wai Long Tam,F. O. Dorien,Kunihiko Hiramatsu,Noriyuki Tsumaki,Frank P. Luyten,Scott J. Roberts, CELLULAR REPROGRAMMING, MARY ANN LIEBERT, INC, Vol. 16, No. 1, p. 29-39, 2014/02
  • Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters, Y. Minegishi,K. Hosokawa,N. Tsumaki, OSTEOARTHRITIS AND CARTILAGE, ELSEVIER SCI LTD, Vol. 21, No. 12, p. 1968-1975, 2013/12
  • Direct Induction of Chondrogenic Cells from Human Dermal Fibroblast Culture by Defined Factors, Hidetatsu Outani,Minoru Okada,Akihiro Yamashita,Kanako Nakagawa,Hideki Yoshikawa,Noriyuki Tsumaki, PLoS ONE, Vol. 8, No. 10, 2013/10/16
  • iPS細胞を使うー軟骨の研究へ, 妻木範行,岡田稔,山下晃弘, 整形外科, Vol. 64, No. 10, p. 1106-1109, 2013
  • iPS細胞由来軟骨細胞を用いた再生治療開発, 山下晃弘,妻木範行, Phama Medica, Vol. 31, No. 4, p. 29-32, 2013
  • Stem cell aging and the implications for stem cell-based therapies for aging-related diseases and aged tissues, Fujita K,Tsumaki N, Clin Calcium., Vol. 23, p. 65-73, 2013/01
  • Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification, Riko Nishimura,Makoto Wakabayashi,Kenji Hata,Takuma Matsubara,Shiho Honma,Satoshi Wakisaka,Hiroshi Kiyonari,Go Shioi,Akira Yamaguchi,Noriyuki Tsumaki,Haruhiko Akiyama,Toshiyuki Yoneda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 287, No. 40, p. 33179-33190, 2012/09
  • Sp1ファミリーの転写因子は骨肉腫由来骨芽細胞様細胞株においてXI型コラーゲンα2鎖遺伝子の転写活性を制御する, 箭原 康人,松井 好人,東元 真実,鈴木 賀代,妻木 範行,木村 友厚, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 86, No. 8, p. S1385-S1385, 2012/08
  • An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene, Kohji Miura,Noriyuki Namba,Makoto Fujiwara,Yasuhisa Ohata,Hidekazu Ishida,Taichi Kitaoka,Takuo Kubota,Haruhiko Hirai,Chikahisa Higuchi,Noriyuki Tsumaki,Hideki Yoshikawa,Norio Sakai,Toshimi Michigami,Keiichi Ozono, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 7, No. 8, 2012/08
  • Sp1、3、7/Osterixは様々な骨肉腫由来細胞株においてCOL11A2の転写活性を制御する, 箭原 康人,松井 好人,東元 真実,鈴木 賀代,妻木 範行,木村 友厚, 日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, 日本結合組織学会・マトリックス研究会, Vol. 44回・59回, p. 60-60, 2012/06
  • Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice, Tatsuya Uebi,Yumi Itoh,Osamu Hatano,Ayako Kumagai,Masato Sanosaka,Tsutomu Sasaki,Satoru Sasagawa,Junko Doi,Keita Tatsumi,Kuniko Mitamura,Eiichi Morii,Katsuyuki Aozasa,Tomohiro Kawamura,Meinoshin Okumura,Jun Nakae,Hajime Takikawa,Toshio Fukusato,Minako Koura,Mayumi Nish,Anders Hamsten,Angela Silveira,Alejandro M. Bertorello,Kazuo Kitagawa,Yasuo Nagaoka,Hidehisa Kawahara,Takeshi Tomonaga,Tetsuji Naka,Shigeo Ikegawa,Noriyuki Tsumaki,Junichiro Matsuda,Hiroshi Takemori, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 7, No. 5, 2012/05
  • SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice, Satoru Sasagawa,Hiroshi Takemori,Tatsuya Uebi,Daisuke Ikegami,Kunihiko Hiramatsu,Shiro Ikegawa,Hideki Yoshikawa,Noriyuki Tsumaki, Development, COMPANY OF BIOLOGISTS LTD, Vol. 139, No. 6, p. 1153-1163, 2012/03
  • Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice, Mina Okamoto,Junko Murai,Yuuki Imai,Daisuke Ikegami,Nobuhiro Kamiya,Shigeaki Kato,Yuji Mishina,Hideki Yoshikawa,Noriyuki Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, WILEY-BLACKWELL, Vol. 26, No. 10, p. 2511-2522, 2011/10
  • Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state, Hidetatsu Outani,Minoru Okada,Kunihiko Hiramatsu,Hideki Yoshikawa,Noriyuki Tsumaki, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 411, No. 3, p. 607-612, 2011/08
  • ナトリウム利尿ペプチド受容体Bの機能獲得型変異はヒトおよびマウスにおいて成長促進と低骨密度をもたらす, 三浦 弘司,難波 範行,藤原 誠,北岡 太一,大幡 泰久,平井 治彦,大薗 恵一,樋口 周久,妻木 範行,吉川 秀樹,道上 敏美, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 29回, p. 180-180, 2011/07
  • Expression of dominant negative TGF-beta receptors inhibits cartilage formation in conditional transgenic mice, Kunihiko Hiramatsu,Takao Iwai,Hideki Yoshikawa,Noriyuki Tsumaki, JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER TOKYO, Vol. 29, No. 4, p. 493-500, 2011/07
  • Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways, Daisuke Ikegami,Haruhiko Akiyama,Akira Suzuki,Takashi Nakamura,Toru Nakano,Hideki Yoshikawa,Noriyuki Tsumaki, DEVELOPMENT, COMPANY OF BIOLOGISTS LTD, Vol. 138, No. 8, p. 1507-1519, 2011/04
  • Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25, Yukio Nakamura,Koji Yamamoto,Xinjun He,Bungo Otsuki,Youngwoo Kim,Hiroki Murao,Tsunemitsu Soeda,Noriyuki Tsumaki,Jian Min Deng,Zhaoping Zhang,Richard R. Behringer,Benoit de Crombrugghe,John H. Postlethwait,Matthew L. Warman,Takashi Nakamura,Haruhiko Akiyama, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 2, 2011/03
  • Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage, D. Ikegami,T. Iwai,S. Ryo,N. Gu,T. Sugiyama,I. Oh,H. Yoshikawa,N. Tsumaki, OSTEOARTHRITIS AND CARTILAGE, ELSEVIER SCI LTD, Vol. 19, No. 2, p. 233-241, 2011/02
  • Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors, Kunihiko Hiramatsu,Satoru Sasagawa,Hidetatsu Outani,Kanako Nakagawa,Hideki Yoshikawa,Noriyuki Tsumaki, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 121, No. 2, p. 640-657, 2011/02
  • Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development, Dai Suzuki,Atsushi Yamada,Takanori Amano,Rika Yasuhara,Ayako Kimura,Mizuho Sakahara,Noriyuki Tsumaki,Shu Takeda,Masaru Tamura,Masanori Nakamura,Naoyuki Wada,Tsutomu Nohno,Toshihiko Shiroishi,Atsu Aiba,Ryutaro Kamijo, DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 335, No. 2, p. 396-406, 2009/11
  • Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene. (vol 275, pg 12712, 2000), Ying Liu,Haochuan Li,Kazuhiro Tanaka,Noriyuki Tsumaki,Yoshihiko Yamada, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 284, No. 17, p. 11748-11748, 2009/04
  • Generation of Rac1 conditional mutant mice by Cre/loxP system, Dai Suzuki,Atsushi Yamada,Takanori Amano,Ayako Kimura,Rika Yasuhara,Mizuho Sakahara,Masaru Tamura,Noriyuki Tsumaki,Shu Takeda,Masanori Nakamura,Toshihiko Shiroishi,Atsu Aiba,Ryutaro Kamijo, TRANSMITTERS AND MODULATORS IN HEALTH AND DISEASE, SPRINGER-VERLAG BERLIN, p. 175-+, 2009
  • Bone biology: Development and regeneration mechanisms in physiological and pathological conditions, Hideki Yoshikawa,Noriyuki Tsumaki,Akira Myoui, Strategies in Regenerative Medicine: Integrating Biology with Materials Design, Springer New York, p. 431-448, 2009
  • Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2, Junko Murai,Daisuke Ikegami,Mina Okamoto,Hideki Yoshikawa,Noriyuki Tsumaki, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 41, p. 27677-27687, 2008/10
  • Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways, Takao Iwai,Junko Murai,Hideki Yoshikawa,Noriyuki Tsumaki, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 40, p. 27154-27164, 2008/10
  • Characteristics of fracture and related factors in patients with rheumatoid arthritis, Akihide Nampei,Jun Hashimoto,Junichiro Koyanagi,Takeshi Ono,Hideo Hashimoto,Noriyuki Tsumaki,Tetsuya Tomita,Kazuomi Sugamoto,Norihiro Nishimoto,Takahiro Ochi,Hideki Yoshikawa, MODERN RHEUMATOLOGY, SPRINGER, Vol. 18, No. 2, p. 170-176, 2008/04
  • Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic, Iwai, Takao,Harada, Yoshifumi,Imura, Koichi,Iwabuchi, Sadahiro,Murai, Junko,Hiramatsu, Kunihiko,Myoui, Akira,Yoshikawa, Hideki,Tsumaki, Noriyuki, JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER JAPAN KK, Vol. 25, No. 6, p. 392-399, 2007/11
  • Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts, Tadashi Sugiki,Taro Uyama,Masashi Toyoda,Hideo Morioka,Shoen Kume,Kenji Miyado,Kenji Matsumoto,Hirohisa Saito,Noriyuki Tsumaki,Yoriko Takahashi,Yoshiaki Toyama,Akihiro Umezawa, JOURNAL OF CELLULAR BIOCHEMISTRY, WILEY-LISS, Vol. 100, No. 5, p. 1240-1254, 2007/04
  • Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification, Makoto Hirao,Noriyuki Tamai,Noriyuki Tsumaki,Hideki Yoshikawa,Akira Myoui, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 41, p. 31079-31092, 2006/10
  • Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development, M Okamoto,J Murai,H Yoshikawa,N Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 21, No. 7, p. 1022-1033, 2006/07
  • [Bone morphogenetic proteins and their related molecules in the skeletal tissue]., Tsumaki N,Yoshikawa H, Clinical calcium, Vol. 16, No. 5, p. 787-792, 2006/05
  • [Roles of BMPs during endochondral bone formation]., Iwai T,Tsumaki N,Yoshikawa H, Nihon rinsho. Japanese journal of clinical medicine, Vol. 63 Suppl 10, p. 431-434, 2005/10
  • The role of bone morphogenetic proteins in endochondral bone formation, N Tsumaki,H Yoshikawa, CYTOKINE & GROWTH FACTOR REVIEWS, ELSEVIER SCI LTD, Vol. 16, No. 3, p. 279-285, 2005/06
  • Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis, N Tsumaki,M Kakiuchi,J Sasaki,T Ochi,H Yoshikawa, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, JOURNAL BONE JOINT SURGERY INC, Vol. 86A, No. 11, p. 2399-2405, 2004/11
  • Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow, R Katayama,S Wakitani,N Tsumaki,Y Morita,Matsushita, I,R Gejo,T Kimura, RHEUMATOLOGY, OXFORD UNIV PRESS, Vol. 43, No. 8, p. 980-985, 2004/08
  • [Role of BMPs and Smads during endochondral bone formation]., Tsumaki N,Horiki M,Murai J,Yoshikawa H, Clinical calcium, Vol. 14, No. 7, p. 52-57, 2004/07
  • Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia, M Horiki,T Imamura,M Okamoto,M Hayashi,J Murai,A Myoui,T Ochi,K Miyazono,H Yoshikawa,N Tsumaki, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 165, No. 3, p. 433-445, 2004/05
  • 低リン血症性骨軟化症を併発したと考えられる関節リウマチの1例, 牧野 孝洋,橋本 淳,橋本 英雄,妻木 範行,冨田 哲也,菅本 一臣,吉川 秀樹, 中部日本整形外科災害外科学会雑誌, 中部日本整形外科災害外科学会, Vol. 47, No. 2, p. 375-376, 2004/03
  • COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG, Y Matsui,HA Chansky,F Barahmand-Pour,A Zielinska-Kwiatkowska,N Tsumaki,A Myoui,H Yoshikawa,L Yang,DR Eyre, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 278, No. 13, p. 11369-11375, 2003/03
  • Cartilage-specific overexpression of C-propeptide of type II collagen affected matrix mineralization in transgenic mice, Y. Matsui,K. Nakata,E. Adachi,N. Tsumaki,T. Kimura,N. Yasui,E. Kataoka,Y. Fujita,H. Tsuboi,H. Yoshikawa, Journal of Musculoskeletal Research, Vol. 7, No. 3-4, p. 183-189, 2003
  • Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells, Y Matsui,N Araki,H Tsuboi,N Tsumaki,K Nakata,H Kawabata,DR Eyre,H Yoshikawa, ANTICANCER RESEARCH, INT INST ANTICANCER RESEARCH, Vol. 22, No. 6C, p. 4169-4172, 2002/11
  • Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis, N Tsumaki,T Nakase,T Miyaji,M Kakiuchi,T Kimura,T Ochi,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 17, No. 5, p. 898-906, 2002/05
  • Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff, Takanobu Nakase,Kazuomi Sugamoto,Takashi Miyamoto,Noriyuki Tsumaki,Frank P. Luyten,Hiroaki Inui,Akira Myoui,Tetsuya Tomita,Hideki Yoshikawa, Clinical Orthopaedics and Related Research, Lippincott Williams and Wilkins, No. 399, p. 140-145, 2002
  • Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum, T Nakase,K Ariga,K Yonenobu,N Tsumaki,FP Luyten,Y Mukai,Sato, I,H Yoshikawa, EUROPEAN SPINE JOURNAL, SPRINGER-VERLAG, Vol. 10, No. 4, p. 289-294, 2001/08
  • Alternative splicing of fibronectin transcripts in osteochondrogenic tumors, Y Matsui,K Nakata,N Araki,K Ozono,Y Fujita,N Tsumaki,H Kawabata,N Yasui,K Sekiguchi,H Yoshikawa, ANTICANCER RESEARCH, INT INST ANTICANCER RESEARCH, Vol. 21, No. 2A, p. 1103-1106, 2001/03
  • Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene, Y Liu,HC Li,K Tanaka,N Tsumaki,Y Yamada, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 275, No. 17, p. 12712-12718, 2000/04
  • Enhancer analysis of the alpha 1(II) and alpha 2(XI) collagen genes in transfected chondrocytes and transgenic mice., N. Tsumaki,Y. Liu,Y. Yamada,P. Krebsbach, Methods in molecular biology (Clifton, N.J.), Vol. 139, p. 187-195, 2000
  • A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia, Y Matsui,N Yasui,H Kawabata,K Ozono,K Nakata,T Mizushima,N Tsumaki,E Kataoka,Y Fujita,T Ochi, JOURNAL OF HUMAN GENETICS, SPRINGER-VERLAG TOKYO, Vol. 45, No. 2, p. 105-108, 2000
  • Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation, N Tsumaki,K Tanaka,E Arikawa-Hirasawa,T Nakase,T Kimura,JT Thomas,T Ochi,FP Luyten,Y Yamada, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 144, No. 1, p. 161-173, 1999/01
  • Genotype phenotype correlation in achondroplasia and hypochondroplasia, Y Matsui,N Yasui,T Kimura,N Tsumaki,H Kawabata,T Ochi, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, BRITISH EDITORIAL SOC BONE JOINT SURGERY, Vol. 80B, No. 6, p. 1052-1056, 1998/11
  • Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha 2(XI) collagen promoter, N Tsumaki,T Kimura,K Tanaka,JH Kimura,T Ochi,Y Yamada, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 273, No. 36, p. 22861-22864, 1998/09
  • Differential in situ expression of alpha 2(XI) collagen mRNA isoforms in the developing mouse, M Sugimoto,T Kimura,N Tsumaki,Y Matsui,K Nakata,H Kawahata,N Yasui,Y Kitamura,S Nomura,T Ochi, CELL AND TISSUE RESEARCH, SPRINGER VERLAG, Vol. 292, No. 2, p. 325-332, 1998/05
  • Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors, Y Matsui,T Kimura,N Tsumaki,K Nakata,N Yasui,N Araki,N Hashimoto,A Uchida,T Ochi, CANCER LETTERS, ELSEVIER SCI IRELAND LTD, Vol. 124, No. 2, p. 143-148, 1998/02
  • A recurrent 1992delCT mutation of the type X collagen gene in a Japanese patient with Schmid metaphyseal chondrodysplasia, Y Matsui,T Kimura,N Tsumaki,N Yasui,T Ochi, JAPANESE JOURNAL OF HUMAN GENETICS, TOKYO MEDICAL DENTAL UNIV, Vol. 41, No. 3, p. 339-342, 1996/09
  • Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage, N Tsumaki,T Kimura,Y Matsui,K Nakata,T Ochi, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 134, No. 6, p. 1573-1582, 1996/09
  • Cervical spondylotic radiculopathy involving two adjacent nerve roots - Anterior decompression through a single level intervertebral approach, M Iwasaki,K Okada,N Tsumaki,H Obata,N Shirasaki,S Oka, INTERNATIONAL ORTHOPAEDICS, SPRINGER VERLAG, Vol. 20, No. 3, p. 137-141, 1996/06
  • Progressive degeneration of articular cartilage and intervertebral discs - An experimental study in transgenic mice bearing a type IX collagen mutation, T Kimura,K Nakata,N Tsumaki,S Miyamoto,Y Matsui,S Ebara,T Ochi, INTERNATIONAL ORTHOPAEDICS, SPRINGER VERLAG, Vol. 20, No. 3, p. 177-181, 1996/06
  • Separable regulatory elements from pro-alpha 2(XI) collagen gene drive distinct patterns of cartilage-specific expression in transgenic mice, N Tsumaki,M Sugimoto,K Nakata,Y Matsui,T Ochi,T Kimura, MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE, NEW YORK ACAD SCIENCES, Vol. 785, p. 340-342, 1996
  • DIFFERENTIAL EXPRESSION OF AN ACIDIC DOMAIN IN THE AMINO-TERMINAL PROPEPTIDE OF MOUSE PRO-ALPHA-2(XI) COLLAGEN BY COMPLEX ALTERNATIVE SPLICING, N TSUMAKI,T KIMURA, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 270, No. 5, p. 2372-2378, 1995/02
  • ALTERED CHONDROCYTE GENE-EXPRESSION IN ARTICULAR-CARTILAGE MATRIX COMPONENTS AND SUSCEPTIBILITY TO CARTILAGE DESTRUCTION, T KIMURA,K NAKATA,N TSUMAKI,K ONO, CELL MECHANICS AND CELLULAR ENGINEERING, SPRINGER-VERLAG, p. 445-456, 1994

Misc.

  • Salt inducible kinase 3 (SIK3) mediate shear stress-induced up-regulation of lubricin at the articular cartilage surface, 武井義明,武井義明,小林与人,堀家なな緒,森岡美帆,高才東,釜谷崇志,山下晃弘,竹森洋,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 33rd, 2020
  • 椎間板変性に対する選択的c-Fos/AP-1阻害薬の治療効果, 牧野紘士,関庄二,箭原康人,塩沢俊一,妻木範行,木村友厚, 日本軟骨代謝学会プログラム・抄録集, Vol. 31st, 2018
  • Application of iPS cell technologies to regenerate articular cartilage damage and model skeletal dysplasia, Tsumaki Noriyuki, Proceedings for Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society, Vol. WCP2018, 2018
  • A Therapeutic Target of Intervertebral Disc Disease and Regeneration Based on Suppressing Intervertebral Disc Degeneration, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, Vol. 8, No. 6, p. 1127-1131, 2017/06
  • iPS細胞および分子標的によるOA治療戦略 (特集 OAの最新治療 : 関節再生を目指して), 妻木 範行, 分子リウマチ治療, 先端医学社, Vol. 10, No. 2, p. 61-64, 2017/05
  • ROLE OF SIK3 IN PATHOLOGY OF OSTEOARTHRITIS IN MICE, N. Tsumaki, OSTEOARTHRITIS AND CARTILAGE, ELSEVIER SCI LTD, Vol. 25, p. S5-S6, 2017/04
  • ヒトiPS細胞由来軟骨移植の安全性評価-ラット膝関節軟骨欠損モデルを用いて-, 小林与人,小林与人,山下晃弘,森岡美帆,釜谷崇志,高才東,KNUT Woltjen,松田秀一,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 30th, 2017
  • 疾患特異的ヒトiPS細胞を用いた内軟骨性骨化モデル, 木村武司,木村武司,安田紀恵,窪田拓生,三善陽子,山下晃弘,妻木範行,大薗恵一, 日本小児内分泌学会学術集会プログラム・抄録集, Vol. 51st, 2017
  • Application of iPS cell technologies to regeneration of cartilage damage, Osaka Academy of Oral Implantology, Vol. 31, p. 17-19, 2017
  • ESTABLISHMENT OF A HUMAN GROWTH PLATE MODEL WITH IPS CELL-DERIVED CARTILAGE, Takeshi Kimura,Akihiro Yamashita,Keiichi Ozono,Noriyuki Tsumaki, HORMONE RESEARCH IN PAEDIATRICS, KARGER, Vol. 88, p. 9-10, 2017
  • Use of Cell iPS Cell Technologies in Cartilage Regeneration and Disease Modelling of Skeletal Dysplasia, Vol. 71, No. 8, p. 1726-1731, 2016/08
  • Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (vol 7, 10959, 2016), Yasuhito Yahara,Hiroshi Takemori,Minoru Okada,Azuma Kosai,Akihiro Yamashita,Tomohito Kobayashi,Kaori Fujita,Yumi Itoh,Masahiro Nakamura,Hiroyuki Fuchino,Nobuo Kawahara,Naoshi Fukui,Akira Watanabe,Tomoatsu Kimura,Noriyuki Tsumaki, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 7, 2016/06
  • SIK3経路阻害剤は変形性関節症の進行を抑制する, 箭原康人,箭原康人,竹森洋,木村友厚,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 29th, 2016
  • SIK3をターゲットとした変形性関節症の治療, 箭原康人,竹森洋,岡田稔,高才東,山下晃弘,小林与人,藤田香里,伊東裕美,中村正裕,渕野裕之,川原信夫,福井尚志,渡辺亮,木村友厚,妻木範行, 日本骨代謝学会学術集会プログラム抄録集, Vol. 34th, 2016
  • ヒトiPS細胞由来軟骨細胞の免疫原性の解析, 木村武司,木村武司,森岡美穂,山下晃弘,大薗恵一,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 29th, 2016
  • P2-52-6 ダイレクトリプログラミング技術を用いた2型コラーゲン異常症の疾患モデル系の確立(Group52 胎児・新生児の病理,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会), 澤井 英明,室月 淳,妻木 範行, 日本産科婦人科學會雜誌, 日本産科婦人科学会, Vol. 68, No. 2, p. 771-771, 2016
  • スタチンによるFGFR3軟骨形成異常症の病態回復, 山下晃弘,森岡美帆,岸宏美,木村武司,箭原康人,岡田稔,藤田香里,澤井英明,池川志郎,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 29th, 2016
  • Application of cell reprogramming technologies to research for cartilage diseases, Vol. 89, No. 12, p. 1017-1024, 2015/12
  • Chondrogenic differentiation of human iPS cells and production of hyaline cartilaginous tissue, Vol. 14, No. 4, p. 378-382, 2015/11
  • Drug screening using iPS cell model and direct reprogramming technologies, Vol. 58, No. 3, p. 325-330, 2015/03
  • 生後軟骨の恒常性維持におけるSIK3の役割, 箭原康人,箭原康人,木村友厚,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 28th, 2015
  • ヒトiPS細胞から硝子軟骨様組織への分化誘導法の確立, 山下晃弘,森岡美帆,箭原康人,岡田稔,小田直純,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 28th, 2015
  • ヒトiPS細胞を用いた移植可能な軟骨様組織の作成, 山下晃弘,森岡美帆,箭原康人,岡田稔,妻木範行, 再生医療, Vol. 14, 2015
  • 疾患特異的iPS細胞モデルを用いた軟骨形成に対するIGF1の効果の検討, 木村武司,木村武司,森岡美穂,山下晃弘,妻木範行,大薗恵一, 日本整形外科学会雑誌, Vol. 89, No. 9, 2015
  • The effect of IGF-1 on chondrogcnic differentiation model with disease-specific human induced pluripotent stem cells, Vol. 63, No. 1, p. 3-5, 2015/01
  • Cartilage regeneration, modeling of skeletal dysplasia and cell reprogramming technologies, Vol. 251, No. 4, p. 321-327, 2014/10/25
  • Direct reprogramming toward chondrocytes, Vol. 46, No. 5, p. 216-219, 2014/05
  • DERIVATION OF TRANSPLANTABLE CARTILAGE FROM HUMAN INDUCED PLURIPOTENT STEM CELLS, A. Yamashita,M. Morioka,Y. Yahara,M. Okada,N. Tsumaki, OSTEOARTHRITIS AND CARTILAGE, ELSEVIER SCI LTD, Vol. 22, p. S30-S30, 2014/04
  • Cartilage regeneration by chondrogenic cells generated by cell reprogramming technologies, Vol. 56, No. 5, p. 573-584, 2013/04
  • Regulation of chondrocyte differentiation and cartilage regeneration, Vol. 45, No. 1, p. 9-13, 2013/01
  • 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築, 室月淳,澤井英明,山田崇弘,堤誠司,佐藤秀平,林聡,篠塚憲男,高橋雄一郎,佐世正勝,鬼頭浩史,沼部博直,宮崎治,緒方勤,池川志郎,妻木範行,芳賀信彦,西村玄, 致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書, 2013
  • 細胞リプログラミング技術を用いたII型コラーゲン病疾患モデルの解析, 岡田稔,池川志郎,今泉和則,澤井英明,室月淳,大橋博文,妻木範行, 日本軟骨代謝学会プログラム・抄録集, Vol. 26th, 2013
  • 致死性骨異形成症の診断と予後に関する研究 致死性骨異形成症のiPS細胞作成に関する研究, 妻木範行,澤井英明,室月淳,池川志郎, 致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書, 2013
  • ナトリウム利尿ペプチド受容体B(NPR-B)変異に起因する軟骨の表現型の解析, 三浦 弘司,難波 範行,藤原 誠,大幡 泰久,北岡 太一,窪田 拓生,大薗 恵一,樋口 周久,吉川 秀樹,妻木 範行,道上 敏美, 日本内分泌学会雑誌, (一社)日本内分泌学会, Vol. 88, No. 1, p. 203-203, 2012/04
  • 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築, 室月淳,澤井英明,山田崇弘,堤誠司,佐藤秀平,林聡,篠塚憲男,高橋雄一郎,佐世正勝,鬼頭浩史,沼部博直,宮崎治,緒方勤,池川志郎,妻木範行,西村玄, 致死性骨異形成症の診断と予後に関する研究 平成23年度 総括・分担研究報告書, 2012
  • Directed induction of chondrogenic cells from mouse dermal fibroblast culture, Noriyuki Tsumaki, ARTHRITIS RESEARCH & THERAPY, BIOMED CENTRAL LTD, Vol. 14, 2012
  • Direct induction of chondrogenic cells from mouse dermal fibroblast culture, Vol. 239, No. 14, p. 1332-1337, 2011/12/31
  • A GAIN-OF-FUNCTION TYPE MUTATION OF THE NATRIURETIC PEPTIDE RECEPTOR B CAUSES ACCELERATION OF SKELETAL GROWTH AND OSTEOPOROTIC CHANGE IN HUMANS AND MICE, K. Miura,N. Namba,M. Fujiwara,T. Kitaoka,Y. Ohata,H. Hirai,C. Higuchi,N. Tsumaki,H. Yoshikawa,T. Michigami,K. Ozono, OSTEOPOROSIS INTERNATIONAL, SPRINGER LONDON LTD, Vol. 22, p. S536-S536, 2011/09
  • CILP(cartilage intermediate layer protein)トランスジェニックマウスの椎間板変性促進効果, 関庄二,妻木範行,松井好人,川口善治,阿部由美子,鈴木賀代,岩井昭子,佐野明美,尾矢剛志,池川志郎,木村友厚, 日本整形外科学会雑誌, Vol. 84, No. 8, 2010
  • 関節リウマチ患者骨髄中の原因病巣を探り続けて, 越智 隆弘,吉川 秀樹,橋本 淳,中田 研,妻木 範行,冨田 哲也,島岡 康則,蛯名 耕介,武 靖浩,鈴木 隆二,澤井 高志, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 83, No. 8, p. S1004-S1004, 2009/08
  • Essential role of small GTPase Rac1 during limb development, D. Suzuki,A. Yamada,T. Amano,A. Kimura,R. Yasuhara,M. Sakahara,M. Tamura,N. Tsumaki,S. Takeda,M. Nakamura,T. Shiroishi,A. Aiba,R. Kamijo, BONE, ELSEVIER SCIENCE INC, Vol. 44, p. S50-S51, 2009/05
  • Rac1はプログラム細胞死関連遺伝子の発現調節を介して肢芽指間域におけるアポトーシスを制御する, 鈴木 大,山田 篤,天野 孝紀,木村 文子,安原 理佳,妻木 範行,竹田 秀,田村 勝,中村 雅典,城石 俊彦,饗場 篤,上條 竜太郎, 口腔組織培養学会誌, 日本口腔組織培養学会, Vol. 18, No. 1, p. 5-6, 2009/02
  • 低分子量Gタンパク質Rac1は四肢形成に必須である, 鈴木 大,山田 篤,木村 文子,安原 理佳,妻木 範行,竹田 秀,松本 貴志,馬場 一美,中村 雅典,饗場 篤,上條 竜太郎, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 26回, p. 138-138, 2008/10
  • 低分子量Gタンパク質Rac1は四肢形成に必須である, 鈴木 大,山田 篤,安原 理佳,木村 文子,妻木 範行,竹田 秀,中村 雅典,饗場 篤,上條 竜太郎, 補体シンポジウム講演集, (一社)日本補体学会, Vol. 45, p. 181-181, 2008/07
  • Inhibitory Smad6 and Smad7 differently regulate cartilage formation, T. Iwai,J. Murai,H. Yoshikawa,N. Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 22, p. S100-S100, 2007/09
  • Analysis of the function of the CTCF-binding site between the Rxrb and the Col11a2 genes, J. Murai,M. Okamoto,H. Yoshikawa,N. Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 22, p. S260-S260, 2007/09
  • 最新原著レビュー 低出力超音波パルス照射は片側仮骨延長法を用いた高位脛骨骨切り術における延長仮骨治癒を促進する, 妻木 範行, 整形外科, 南江堂, Vol. 57, No. 11, p. 1531-1535, 2006/10
  • Regulation of the col11a2 expression through the histone modification., J. Murai,H. Yoshikawa,N. Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 21, p. S340-S340, 2006/09
  • Role of Smad7 during endochondral bone formation., T. Iwai,J. Murai,H. Yoshikawa,N. Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 21, p. S33-S33, 2006/09
  • Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene (vol 275, pg 12712, 2000), Y Liu,HC Li,K Tanaka,N Tsumaki,Y Yamada, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 27, p. 18908-18908, 2006/07
  • 連通気孔を有する3D-CAD人工骨を用いた高位脛骨骨切術の短期成績, 妻木 範行,海渡 貴司,岩井 貴男,村瀬 剛,名井 陽,吉川 秀樹, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 80, No. 3, p. S103-S103, 2006/03
  • CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよびハイドロキシアパタイトインプラントの術前モデリング, 海渡 貴司,名井 陽,村瀬 剛,妻木 範行,冨田 哲也,吉川 秀樹, Orthopaedic Ceramic Implants, 整形外科バイオマテリアル研究会, Vol. 23〜24, p. 119-124, 2005/12
  • CTデータに基づく3D-CADモデルを利用したハイドロキシアパタイトインプラントの術前モデリング, 村瀬 剛,海渡 貴司,名井 陽,玉井 宣行,妻木 範行,冨田 哲也,森友 寿夫,岡 久仁洋,吉川 秀樹, 日本バイオマテリアル学会大会予稿集, 日本バイオマテリアル学会, Vol. 27回, p. 288-288, 2005/11
  • BMP signaling in bone stimulates osteoclastic bone resorption and remodeling during endochondral bone formation and fracture repair., M Okamoto,J Murai,H Yoshikawa,N Tsumaki, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 20, No. 9, p. S322-S322, 2005/09
  • Hypoxia promotes cartilage matrix synthesis via p38 MAPKinase and suppresses terminal differentiation via HDAC4, M Hirao,N Tamai,A Myoui,N Tsumaki,N Araki,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 20, No. 9, p. S7-S7, 2005/09
  • Low-intensity pulsed ultrasound and new bone formation within interconnected porous calcium hydroxyapatite ceramics., T Iwai,N Tsumaki,J Murai,A Myoui,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 20, No. 9, p. S210-S210, 2005/09
  • Fracture incidence and risk factors in patients with rheumatoid arthritis, A Nampei,J Hashimoto,J Koyanagi,H Hashimoto,N Tsumaki,T Tomita,K Sugamoto,N Nishimoto,H Yoshikawa,T Ochi, ANNALS OF THE RHEUMATIC DISEASES, BMJ PUBLISHING GROUP, Vol. 64, p. 348-348, 2005/07
  • Role of BMP signals in endochondral ossification and fracture repair; Activation of osteoclastic resorption and remodeling of bone, M Okamoto,J Murai,H Yoshikawa,N Tsumaki, BONE, ELSEVIER SCIENCE INC, Vol. 36, p. S118-S118, 2005/06
  • Overexpression of BMP4 in bone increased osteoclast number and caused osteopenia, J Murai,M Okamoto,H Yoshikawa,N Tsumaki, BONE, ELSEVIER SCIENCE INC, Vol. 36, p. S119-S119, 2005/06
  • Bone morphogenetic protein signaling in chondrocyte proliferation and hypertrophy during endochondral bone formation, T Iwai,M Horiki,J Murai,H Yoshikawa,N Tsumaki, BONE, ELSEVIER SCIENCE INC, Vol. 36, p. S174-S175, 2005/06
  • Effect of low-intensity pulsed ultrasound on maturation of callus in opening-wedge high tibial osteotomy by hemicallotasis, TSUMAKI Noriyuki,KAKIUCHI Masaaki,SASAKI Jiro,OCHI Takahiro,YOSHIKAWA Hideki, Vol. 16, p. 155-156, 2005/05/20
  • CTデータに基づく3D-CADを利用したハイドロキシアパタイトインプラントの術前モデリング, 村瀬 剛,海渡 貴司,名井 陽,玉井 宣行,妻木 範行,冨田 哲也,森友 寿夫,岡 久仁洋,上田 孝文,菅本 一臣,吉川 秀樹, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 79, No. 3, p. S205-S205, 2005/03
  • CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよび術前ハイドロキシアパタイトインプラントの術前モデリング, 海渡 貴司,名井 陽,村瀬 剛,妻木 範行,冨田 哲也,吉川 秀樹, 整形外科セラミック・インプラント研究会プログラム・抄録集, 整形外科バイオマテリアル研究会, Vol. 24回, p. 26-26, 2004/12
  • Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis, N Tsumaki,M Kakiuchi,J Sasaki,T Ochi,H Yoshikawa, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, JOURNAL BONE JOINT SURGERY INC, Vol. 86A, No. 11, p. 2399-2405, 2004/11
  • Hypoxia promotes chondrocytic differentiation in vitro and cartilaginous matrix synthesis in organ culture via p38 kinase pathway, M Hirao,N Tamai,N Tsumaki,A Myoui,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 19, p. S61-S61, 2004/10
  • Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow, R Katayama,S Wakitani,N Tsumaki,Y Morita,Matsushita, I,R Gejo,T Kimura, RHEUMATOLOGY, OXFORD UNIV PRESS, Vol. 43, No. 8, p. 980-985, 2004/08
  • Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia, M Horiki,T Imamura,M Okamoto,M Hayashi,J Murai,A Myoui,T Ochi,K Miyazono,H Yoshikawa,N Tsumaki, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 165, No. 3, p. 433-445, 2004/05
  • Overexpression of BMP4 in osteoblasts causes osteopenia in transgenic mice, J Murai,N Tsumaki,M Horiki,Y Hashimoto,K Kuriyama,H Yoshikawa, BONE, ELSEVIER SCIENCE INC, Vol. 34, p. S9-S10, 2004
  • Hypoxia promotes chondrocytic differentiation of C3H10T1/2 cells induced by bone morphogenetic protein-2, M Hirao,N Tamai,N Tsumaki,A Myoui,H Yoshikawa, BONE, ELSEVIER SCIENCE INC, Vol. 34, p. S35-S36, 2004
  • Overexpression of BMP4 in osteoblasts causes severe osteopenia in transgenic mice., N Tsumaki,M Horiki,Y Hashimoto,K Kuriyama,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 18, p. S50-S51, 2003/09
  • Overexpression of Smad6 in chondrocytes distinctively disturbs terminal differentiation of chondrocytes and causes osteopenia in transgenic mice., M Horiki,N Tsumaki,A Myoui,T Imamura,H Yoshikawa, JOURNAL OF BONE AND MINERAL RESEARCH, AMER SOC BONE & MINERAL RES, Vol. 18, p. S60-S60, 2003/09
  • Role of Smad6 during cartilage formation, M Horiki,N Tsumaki,A Myoui,T Miyaji,T Imamura,H Yoshikawa, BONE, ELSEVIER SCIENCE INC, Vol. 32, No. 5, p. S110-S110, 2003/05
  • 軟骨形成における11型コラーゲンα2鎖遺伝子の役割と転写制御 (運動器科学の創生), 妻木 範行, 医学のあゆみ, 医歯薬出版, Vol. 205, No. 3, p. 184-186, 2003/04/19
  • 膝内反変形を伴う膝関節内側軟骨障害に対し自家骨軟骨移植術と高位脛骨骨切り術同時施行例の術後成績, 中田 研,史野 根生,桑野 吉浩,福岡 慎一,田川 泰弘,妻木 範行,小畠 秀人,多田 浩一, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 77, No. 3, p. S226-S226, 2003/03
  • COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG, Y Matsui,HA Chansky,F Barahmand-Pour,A Zielinska-Kwiatkowska,N Tsumaki,A Myoui,H Yoshikawa,L Yang,DR Eyre, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 278, No. 13, p. 11369-11375, 2003/03
  • Role of bone morphogenetic protein signals during skeletal development, N Tsumaki,M Horiki,T Kimura,H Yoshikawa, ARTHRITIS RESEARCH & THERAPY, BIOMED CENTRAL LTD, Vol. 5, p. S8-S8, 2003
  • Repair of rabbit articular cartilage defect using CDMP1-transfected autologous mesenchymal stem cell derived from bone marrow., R Katayama,S Wakitani,N Tsumaki,H Matsuno,L Frank,K Yudoh,T Kimura, ARTHRITIS AND RHEUMATISM, WILEY-LISS, Vol. 46, No. 9, p. S585-S585, 2002/09
  • 間葉系細胞と遺伝子導入による修復, 片山 理恵,脇谷 滋之,妻木 範行,松野 博明,木村 友厚, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 76, No. 8, p. S944-S944, 2002/08
  • A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene (Retracted Article), K Tanaka,N Tsumaki,CA Kozak,Y Matsumoto,F Nakatani,Y Iwamoto,Y Yamada, MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, Vol. 22, No. 12, p. 4256-4267, 2002/06
  • Matsui, Y., Araki, N., Tsuboi, H., Tsumaki, N., Nakata, K., Kawabata, H., Eyre, D. R., and Yoshikawa, H.: Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells., Anticancer Res, Vol. 22(6C): 4169-4172, 2002
  • Nakase, T., Sugamoto, K., Miyamoto, T., Tsumaki, N., Luyten, F. P., Inui, H., Myoui, A., Tomita, T., and Yoshikawa, H.: Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff., Clin Orthop, Vol. (399): 140-145, 2002
  • 骨髄由来間葉系幹細胞に対するCDMP1遺伝子導入と軟骨分化誘導の促進, 片山 理恵,脇谷 滋之,妻木 範行,松野 博明,遊道 和雄,木村 友厚, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 75, No. 8, p. S850-S850, 2001/08
  • BMP signals are required for cartilage formation., Tsumaki N.,Nakase T.,Miyaji E. T.,Kakiuchi M.,Ochi T.,Yamada Yoshihiko,Kimura T.,Yoshikawa H., Connective tissue, The Japanese Society for Connective Tissue, Vol. 33, No. 2, p. 169-169, 2001/06
  • Flagエピトープ標識II型コラーゲンCプロペプチド過剰発現マウスにおける外来遺伝子発現の免疫組織学的検索(Demonstration of type II collagen C-propeptide tagged with Flag epitope (DYKDDDDK) in cartilage of transgenic mice), 松井 好人,中田 研,妻木 範行,片岡 英一郎,木村 友厚,Adachi Eijiro,Matsui Yoshito,Nakata Ken,Tsumaki Noriyuki,Kataoka Eiichiro,Kimura Tomoatsu, 解剖学雑誌, (一社)日本解剖学会, Vol. 76, No. 1, p. 68-68, 2001/02
  • Matsui, Y., Nakata, K., Araki, N., Ozono, K., Fujita, Y., Tsumaki, N., Kawabata, H., Yasui, N., Sekiguchi, K., and Yoshikawa, H.: Alternative splicing of fibronectin transcripts in osteochondrogenic tumors., Anticancer Res, Vol. 21(2A): 1103-1106, 2001
  • Role of BMP4 during Chondrocyte Differentiation, TSUMAKI N., Vol. 74, No. 8, 2000/08/25
  • 軟骨性腫瘍におけるフィブロネクチンmRNAの選択的スプライシング, 松井 好人,中田 研,安井 夏生,荒木 信人,大薗 恵一,妻木 範行,藤田 良,栗山 幸治,川端 秀彦,越智 隆弘, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 74, No. 8, p. S1348-S1348, 2000/08/25
  • Involvement of Ptc/Gli-BMP signaling in the Periosteum in the Early Phase of Fracture Repair, NAKASE T., Vol. 74, No. 8, 2000/08/25
  • 軟骨変性と遺伝子の発現 -軟骨細胞signaling pathway における意味づけ-, 妻木 範行,垣内 雅明,吉川 秀樹,木村 友厚,越智 隆弘, リウマチ, Vol. 40, No. 2, p. 263-263, 2000/04/26
  • A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia, Y. Matsui,N. Yasui,H. Kawabata,K. Ozono,K. Nakata,T. Mizushima,N. Tsumaki,E. Kataoka,Y. Fujita,T. Ochi, Journal of Human Genetics, Springer Science and Business Media LLC, Vol. 45, No. 2, p. 105-108, 2000/03
  • Transcriptional Regulation of Cartilage-specific Collagen Gene, Col11a2, TSUMAKI N.,YAMADA Yoshihiko, Vol. 74, No. 2, 2000/02/25
  • Targeted gene expression in human articular cartilage by direct in vivo gene transfer into SCID-HuRAg mouse., R Katayama,T Tomita,N Tsumaki,T Ochi,H Matsuno,Y Morita,K Yudoh,F Nakazawa,T Kimura, ARTHRITIS AND RHEUMATISM, LIPPINCOTT WILLIAMS & WILKINS, Vol. 42, No. 9, p. S107-S107, 1999/09
  • 軟骨の形成・分化に対するBMPシグナルの作用, 妻木 範行,中瀬 尚長,冨田 哲也,吉川 秀樹,垣内 雅明,木村 友厚,YAMADA Y.,越智 隆弘, 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, Vol. 73, No. 8, 1999/08/25
  • 軟骨組織特異的遺伝子発現システムを用いた関節軟骨への in vivo 遺伝子導入, 片山 理恵,冨田 哲也,妻木 範行,越智 隆弘,松野 博明,遊道 和雄,中沢 不二雄,木村 友厚, 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, Vol. 73, No. 8, 1999/08/25
  • II型コラーゲン遺伝子の軟骨特異的エンハンサーに結合するタンパク質(CSEBP-2)の遺伝子発現とゲノム構造の解析, 片岡 英一郎,丹羽 仁史,中田 研,松井 好人,木村 友厚,妻木 範行,山田 吉彦,安井 夏生,宮崎 純一,越智 隆弘, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 73, No. 8, p. S1609-S1609, 1999/08/25
  • II型コラーゲンCプロペプチドが軟骨分化と軟骨基質の石灰化に及ぼす作用 過剰発現トランスジェニックマウスを用いた解析, 松井 好人,中田 研,安達 栄治郎,木村 友厚,妻木 範行,安井 夏生,片岡 英一郎,藤田 良,越智 隆弘, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 73, No. 8, p. S1562-S1562, 1999/08
  • 【変形性関節症の基礎と臨床】 OAの動物モデル, 木村 友厚,松野 博明,遊道 和雄,中田 研,妻木 範行, リウマチ科, (有)科学評論社, Vol. 22, No. 1, p. 4-9, 1999/07
  • ヒト骨軟骨形成性疾患における CDMP (Cartilage-derived morphogenetic protein)-1 遺伝子の発現様式について, 中瀬 尚長,金子 元春,有賀 健太,妻木 範行,冨田 哲也,菅本 一臣,宮本 紳平,名井 陽,吉川 秀樹,米延 策雄,越智 隆弘, 日本骨代謝学会雑誌 = Japanese journal of bone metabolism, Vol. 17, No. 2, p. 296-296, 1999/06/26
  • Identification of the regulatory sequences responsible for cartilage-specific expression of the Col11a2 gene and their application : a role of BMP signals in the skeletal development, Tsumaki N.,Kimura T.,Yamada Y.,Ochi T., Connective tissue, The Japanese Society for Connective Tissue, Vol. 31, No. 2, p. 87-87, 1999/06
  • Identification of a transcription factor that regulates tissue-specific expression of α2(XI)collagen gene., Tanaka K.,Tsumaki N.,Yamada Y.,Iwamoto Y., Connective tissue, The Japanese Society for Connective Tissue, Vol. 31, No. 2, p. 95-95, 1999/06
  • Cartilage degeneration and genes, KIMURA T.,MATSUNO H.,YUDOH K.,TSUMAKI N.,TOMITA T.,OCHI T., Vol. 39, No. 2, p. 230-230, 1999/04/30
  • 軟骨特異的転写制御メカニズムの解明とその応用, 妻木 範行,木村 友厚,YAMADA Yoshihiko,越智 隆弘, リウマチ, Vol. 39, No. 2, p. 269-269, 1999/04/30
  • Immunohistochemical detection of the foreign gene expression in transgenic mice overxpressing the FLAG epitope tagged chondrocalcin in cartilage, Matsui Y,Nakata K,Adachi E,Kimura T,Tsumaki N,Katsumata O,Yasui N,Kataoka E,Fujita Y,Ochi T, Connective tissue, 日本結合組織学会, Vol. 31, No. 2, p. 126-126, 1999
  • Inhibition of proliferation of synovial cells from patients with rheumatoid arthritis by overexpression of p21 gene through induction of apoptosis., T Tomita,E Takeuchi,N Tomita,R Morishita,M Kaneko,H Matsushita,H Takano,N Tsumaki,Y Kaneda,T Ochi, ARTHRITIS AND RHEUMATISM, LIPPINCOTT WILLIAMS & WILKINS, Vol. 41, No. 9, p. S239-S239, 1998/09
  • Identification of a Minimal 30-Base-Pair Sequence Responsible for Cartilage-Specific Expression of the α2 (XI) Collagen Gene, TSUMAKI N.,KIMURA T.,TANAKA K.,KIMURA J. H.,YAMADA Y.,OCHI T., Vol. 72, No. 8, 1998/08/25
  • Role of CDMP-1 in Skeletal Morphogenesis : Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation, TSUMAKI N.,THOMAS J. T.,LUYTEN F. P.,YAMADA Y., Vol. 72, No. 8, 1998/08/25
  • II型コラーゲンCプロペプチド過剰発現マウスにおける内軟骨性骨形成の変化, 松井 好人,中田 研,木村 友厚,妻木 範行,山田 吉彦,安井 夏生,片岡 英一郎,越智 隆弘, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 72, No. 8, p. s1567-s1567, 1998/08/25
  • 軟骨の発生・分化に対する Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) の作用, 妻木 範行,TANAKA K.,ARIKAWA HIRASAWA E.,THOMAS J. T.,越智 隆弘,LUYTEN F. P.,木村 友厚,YAMADA Y., 日本骨代謝学会雑誌 = Japanese journal of bone metabolism, Vol. 16, No. 2, p. 6-6, 1998/07/07
  • Targeted expression of CDMP-1 in mouse cartilage expands primordial cartilage and enhances chondrocyte differentiation, Tsumaki N.,Tanaka K.,Akikawa-Hirasawa E.,Thomas J.T.,Ochi T.,Luyten F.P.,Kimura T.,Yamada Y., Connective tissue, The Japanese Society for Connective Tissue, Vol. 30, No. 2, p. 162-162, 1998/06/05
  • Genes in joint disorders, Kimura Tomoatsu,Tsumaki Noriyuki,Yasui Natsuo,Nakata Ken,Tomita Tetsuya,Kataoka Eiichiro,Ochi Takahiro, Connective tissue, 日本結合組織学会, Vol. 30, No. 2, p. 129-129, 1998
  • Transcriptional regulatory cis-elements of α2(XI) collagen gene, N. Tsumaki,T. Kimura,Y. Matsui,K. Nakata,T. Ochi, Connective Tissue, Vol. 30, p. 75-79, 1998/01/01
  • Differential in situ Expression of Mouse Pro-a2(XI) Collagen during Development, SUGIMOTO M, 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, Vol. 71, No. 8, 1997/08/25
  • 11型コラ-ゲンの構造と機能 (特集 マトリックス生物学の最前線), 木村 友厚,妻木 範行,越智 隆弘, 生体の科学, 金原一郎記念医学医療振興財団, Vol. 48, No. 4, p. 254-259, 1997/08
  • 軟骨マトリックスの異常と関節破壊, 木村 友厚,田邊 誠,中田 研,妻木 範行,松井 好人,越智 隆弘, リウマチ, Vol. 37, No. 2, p. 206-206, 1997/04/01
  • Promoter assay using transgenic mice reveals the presence of cis-acting elements governing tissue and site-specific expression of Col1a2., N Tsumaki,M Sugimoto,Y Matsui,K Nakata,T Ochi,T Kimura, MATRIX BIOLOGY, GUSTAV FISCHER VERLAG, Vol. 15, No. 3, p. 194-194, 1996/09
  • Alternative Splicing of the Primary Transcripts at the N-propeptide Coding Region of Human Pro-α1(XI) and Pro-α2(XI) Collagen in Cartilaginous Tumors, MATSUI Y, 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, Vol. 70, No. 8, 1996/08/25
  • Collagens and Osteo-chondrogenesis, KIMURA T, 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association, Vol. 70, No. 8, 1996/08/25
  • マウスXI型コラーゲンα2鎖遺伝子の軟骨特異的発現にかかわる転写制御領域の解析, 妻木 範行,木村 友厚,松井 好人,杉本 瑞生,中田 研,越智 隆弘, 日本骨代謝学会雑誌 = Japanese journal of bone metabolism, Vol. 14, No. 2, p. 67-67, 1996/06/01
  • マウス発生過程におけるXI型コラーゲンα2鎖 alternative splicing form の発現と局在, 杉本 瑞生,妻木 範行,松井 好人,中田 研,木村 友厚,佐藤 宗彦,川畑 浩久,野村 慎太郎,越智 隆弘, 日本骨代謝学会雑誌 = Japanese journal of bone metabolism, Vol. 14, No. 2, p. 161-161, 1996/06/01
  • A common FGFR3 mutation functions as a diagnostic marker for achondroplasia-group disorders in the Japanese population, MATSUI YOSHITO,KIMURA TOMOATSU,TSUMAKI NORIYUKI,NAKAHARA HARUHIKO,ARAKI NOBUHITO,YASUI NATSUO,OCHI TAKAHIRO, J. Orthop. Sci., Vol. 1, No. 2, p. 130-135, 1996/03/01
  • PROGRESSIVE DEGENERATION OF ARTICULAR-CARTILAGE AND INTERVERTEBRAL DISCS IN TRANSGENIC MICE BEARING A TYPE-IX COLLAGEN MUTATION, T KIMURA,K NAKATA,N TSUMAKI,Y MATSUI,T OCHI, ARTHRITIS AND RHEUMATISM, LIPPINCOTT-RAVEN PUBL, Vol. 38, No. 9, p. 692-692, 1995/09
  • マウスXI型コラーゲンα2鎖遺伝子転写制御領域の解析 トランスジェニックマウスを用いて, 妻木 範行,木村 友厚,中田 研, 日本整形外科学会雑誌, (公社)日本整形外科学会, Vol. 69, No. 8, p. s1737-s1737, 1995/08/25
  • Collagen Genes and Skeletal Disorders, KIMURA Tomoatsu,TSUMAKI Noriyuki,MATSUI Yoshito, Vol. 35, No. 3, p. 600-608, 1995/06
  • 骨軟骨コラーゲン異常モデルマウス, 中田 研,妻木 範行,木村 友厚, Molecular Medicine, (株)中山書店, Vol. 臨増, No. マニュアル疾患モデルマウス, p. 138-146, 1994/12
  • 発生工学を用いた病態動物モデル 軟骨異常トランスジェニックマウスの作製と解析, 中田 研,妻木 範行,木村 友厚, BIO medica, (株)北隆館, Vol. 8, No. 14, p. 1128-1134, 1993/12
  • 肩関節外傷性前方不安定症における関節内病変の進行様式, 妻木 範行,脇谷 滋之,米田 稔, 肩関節, (一社)日本肩関節学会, Vol. 17, No. 1, p. 111-115, 1993/09

Works

  • 厚生労働科学研究費補助金 免疫アレルギー疾患予防・治療研究事業, 2006 -
  • 超音波刺激，人工骨，骨形成因子（BMP）シグナル操作を組み合わせた骨欠損の修復, 2006 -
  • 軟骨細胞シグナリングとマトリックス転写制御による軟骨形成・分化の解明, 2006 -
  • 難治性骨折治癒過程におけるBMPシグナル作用機構の解明, 2005 -

Awards

  • 日本骨代謝学会研究奨励賞, 2008
  • 日本骨代謝学会優秀演題賞, 2000
  • 日本整形外科学会奨励賞, 2000
  • 日本骨代謝学会優秀演題賞, 1998
  • 日本結合組織学会賞, 1997
  • 日本軟骨代謝学会賞, 1996