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iPS Cell-Based Technology for Joint Resurfacing
Takahiro Negishi, Noriyuki Tsumaki
Regenerative Medicine in Sports and Orthopaedics p. 425-434 2025/04/29 Part of collection (book)
Publisher: Springer Nature Switzerland
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SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response to Exogenous Gonadotropins In Vivo
Emily T Hayes, Mariam Hassan, Oliwia Lakomy, Rachael Filzen, Marah Armouti, Marc Foretz, Noriyuki Tsumaki, Hiroshi Takemori, Carlos Stocco
Endocrinology Vol. 165 No. 10 2024/08/19 Research paper (scientific journal)
Publisher: The Endocrine Society
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Subpopulations of fibroblasts derived from human iPS cells
Takashi Kobayashi, Akihiro Yamashita, Noriyuki Tsumaki, Hideto Watanabe
Communications Biology Vol. 7 No. 1 2024/06/18 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Regenerative therapy for articular cartilage damage using iPS cell technology.
妻木範行
生産と技術 Vol. 76 No. 1 2024
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Development of regenerative treatment using iPS cell-derived cartilage organoid
妻木範行, 妻木範行
実験医学 Vol. 42 No. 5 2024
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Strategies for Developing Regenerative Therapies for Articular Cartilage Damage
妻木範行, 妻木範行, 妻木範行
臨床整形外科 Vol. 59 No. 3 2024
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これならわかる骨系統疾患とその周辺 iPS細胞からの軟骨細胞誘導法と疾患iPS細胞モデル
妻木範行, 妻木範行, 妻木範行
周産期医学 Vol. 54 No. 12 2024
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人工臓器-最近の進歩 関節における人工臓器の開発研究:iPS細胞由来軟骨を用いた関節軟骨の構成
妻木範行, 妻木範行, 妻木範行
人工臓器(日本人工臓器学会) Vol. 53 No. 3 2024
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Destruction and regeneration in bone and cartilage
Noriyuki Tsumaki
Inflammation and Regeneration Vol. 43 No. 1 2023/12/13 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity
Kengo Abe, Noriyuki Tsumaki
Inflammation and Regeneration Vol. 43 No. 1 2023/11/14 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles
Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, Noriyuki Tsumaki, Norimasa Nakamura
npj Regenerative Medicine Vol. 8 No. 1 2023/10/19 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone
Hiroki Hagizawa, Saeko Koyamatsu, Seiji Okada, Takashi Kaito, Noriyuki Tsumaki
Frontiers in Cell and Developmental Biology Vol. 11 2023/05/15 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect
Kengo Abe, Akihiro Yamashita, Miho Morioka, Nanao Horike, Yoshiaki Takei, Saeko Koyamatsu, Keisuke Okita, Shuichi Matsuda, Noriyuki Tsumaki
Nature Communications Vol. 14 No. 1 2023/02/20 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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低血清および低酸素条件下におけるiPS細胞由来軟骨細胞シートの硝子軟骨修復能の向上
内山 綾香, 佐藤 正人, 高橋 匠, 豊田 恵利子, 前原 美樹, 大村 はるか, 小川 真梨奈, 森岡 美帆, 山下 晃弘, 渡辺 雅彦, 妻木 範行
日本整形外科学会雑誌 Vol. 96 No. 8 p. S1556-S1556 2022/09
Publisher: (公社)日本整形外科学会
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Universal Surface Biotinylation: a simple, versatile and cost-effective sample multiplexing method for single-cell RNA-seq analysis
Michihiko Sugimoto, Yuhki Tada, Shigeyuki Shichino, Saeko Koyamatsu, Noriyuki Tsumaki, Kuniya Abe
DNA Research Vol. 29 No. 3 2022/05/27 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus
Takashi Kamatani, Hiroki Hagizawa, Seido Yarimitsu, Miho Morioka, Saeko Koyamatsu, Michihiko Sugimoto, Joe Kodama, Junko Yamane, Hiroyuki Ishiguro, Shigeyuki Shichino, Kuniya Abe, Wataru Fujibuchi, Hiromichi Fujie, Takashi Kaito, Noriyuki Tsumaki
Biomaterials Vol. 284 p. 121491-121491 2022/05 Research paper (scientific journal)
Publisher: Elsevier BV
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Generation of monkey iPS cell-derived cartilage lacking MHC class I molecules on the cell surface
Okutani, Yuki, Abe, Kengo, Yamashita, Akihiro, Morioka, Miho, Matsuda, Shuichi, Tsumaki, Noriyuki
Tissue Engineering Part A Vol. 28 No. 1-2 p. 94-106 2022/01 Research paper (scientific journal)
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Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects
Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts, Frank P. Luyten
Stem Cell Research & Therapy Vol. 12 No. 1 2021/12 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice.
Yuki Iimori, Miho Morioka, Saeko Koyamatsu, Noriyuki Tsumaki
Tissue engineering. Part A Vol. 27 No. 21-22 p. 1355-1367 2021/08/16 Research paper (scientific journal)
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Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells
Akihiro Yamashita, Noriyuki Tsumaki
Development, Growth & Differentiation Vol. 63 No. 1 p. 72-81 2021/01 Research paper (scientific journal)
Publisher: Wiley
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Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.
Akihiro Yamashita, Hiroyuki Yoshitomi, Shunsuke Kihara, Junya Toguchida, Noriyuki Tsumaki
Stem cells translational medicine Vol. 10 No. 1 p. 115-127 2021/01 Research paper (scientific journal)
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Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.
Tomonori Ozaki, Tatsuya Kawamoto, Yuki Iimori, Nobuaki Takeshita, Yukiko Yamagishi, Hiroaki Nakamura, Masazumi Kamohara, Kaori Fujita, Masayuki Tanahashi, Noriyuki Tsumaki
Scientific reports Vol. 10 No. 1 p. 20915-20915 2020/12/01 Research paper (scientific journal)
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Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage
Yoshiaki Takei, Miho Morioka, Akihiro Yamashita, Tomohito Kobayashi, Nobuyuki Shima, Noriyuki Tsumaki
Scientific Reports Vol. 10 No. 1 2020/07/30 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Visualization of human iPS cells-derived 3D cartilage tissue by gelatin nanospheres.
Yuki Murata, Jun-Ichiro Jo, Hiroshi Yukawa, Noriyuki Tsumaki, Yoshinobu Baba, Yasuhiko Tabata
Tissue engineering. Part C, Methods Vol. 26 No. 5 p. 244-252 2020/03/06 Research paper (scientific journal)
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Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.
Kosai A, Horike N, Takei Y, Yamashita A, Fujita K, Kamatani T, Tsumaki N
Biochem Biophys Res Commun. Vol. 516 No. 4 p. 1097-1102 2019/09 Research paper (scientific journal)
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量子ドット・磁性ナノ粒子含有ゼラチンナノ粒子を用いたヒトiPS細胞由来3次元軟骨組織の可視化
城 潤一郎, 村田 勇樹, 湯川 博, 妻木 範行, 馬場 嘉信, 田畑 泰彦
JSMI Report Vol. 12 No. 2 p. 123-123 2019/05 Research paper (conference, symposium, etc.)
Publisher: 日本分子イメージング学会
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Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia
Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N
Osteoarthritis and Cartilage Vol. 26 No. 11 p. 1551-1561 2018/11 Research paper (scientific journal)
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Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.
Chen X, Yamashita A, Morioka M, Senba T, Kamatani T, Watanabe A, Kosai A, Tsumaki N
Tissue engineering. Part A Vol. 25 No. 5-6 p. 437-445 2018/10 Research paper (scientific journal)
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椎間板変性および椎間板関連の疼痛に対する選択的c-Fos/AP-1阻害の治療効果
牧野 紘士, 関 庄二, 箭原 康人, 塩沢 俊一, 妻木 範行, 木村 友厚
中部日本整形外科災害外科学会雑誌 Vol. 61 No. 秋季学会 p. 261-261 2018/09 Research paper (conference, symposium, etc.)
Publisher: (一社)中部日本整形外科災害外科学会
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運動器疾患に対するiPS細胞研究の進歩 関節軟骨欠損に対するiPS細胞由来軟骨を用いた治療について
小林 与人, 武井 義明, 山下 晃弘, 森岡 美帆, 釜谷 崇志, 高才 東, Woltjen Knut, 松田 秀一, 妻木 範行
日本整形外科学会雑誌 Vol. 92 No. 8 p. S1938-S1938 2018/08 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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骨代謝と病気の新たなクロストーク:臓器連関から創薬まで 疾患特異的ヒトiPS細胞を用いた成長板軟骨モデルの確立と創薬への応用
木村 武司, 尾崎 友則, 藤田 香里, 山下 晃弘, 森岡 美穂, 大薗 恵一, 妻木 範行
日本骨代謝学会学術集会プログラム抄録集 Vol. 36回 p. 115-115 2018/07 Research paper (conference, symposium, etc.)
Publisher: (一社)日本骨代謝学会
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【腰痛治療の革新-慢性腰痛・神経障害性疼痛に対する治療のbreakthrough】椎間板変性抑制と椎間板再生を目指した治療標的因子
関 庄二, 牧野 紘士, 箭原 康人, 塩沢 俊一, 妻木 範行, 木村 友厚
Journal of Spine Research Vol. 9 No. 6 p. 1017-1021 2018/06 Research paper (conference, symposium, etc.)
Publisher: (一社)日本脊椎脊髄病学会
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Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.
Hiroki Goto, Miki Nishio, Yoko To, Tatsuya Oishi, Yosuke Miyachi, Tomohiko Maehama, Hiroshi Nishina, Haruhiko Akiyama, Tak Wah Mak, Yuma Makii, Taku Saito, Akihiro Yasoda, Noriyuki Tsumaki, Akira Suzuki
Development (Cambridge, England) Vol. 145 No. 6 2018/03/16 Research paper (scientific journal)
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A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation
Tomohito Kobayashi, Kaori Fujita, Takashi Kamatani, Shuichi Matsuda, Noriyuki Tsumaki
Biochemical and Biophysical Research Communications Vol. 495 No. 1 p. 1468-1475 2018/01/01 Research paper (scientific journal)
Publisher: Elsevier B.V.
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Considerations in hiPSC-derived cartilage for articular cartilage repair.
Yamashita A, Tamamura Y, Morioka M, Karagiannis P, Shima N, Tsumaki N
Inflammation and regeneration Vol. 38 p. 17-17 2018 Research paper (scientific journal)
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A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain
Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimura
SCIENTIFIC REPORTS Vol. 7 No. 1 2017/12 Research paper (scientific journal)
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Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages
Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki
TISSUE ENGINEERING PART A Vol. 22 No. 23-24 p. 1367-1375 2016/12 Research paper (scientific journal)
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軟骨細胞特異的なSik3の欠失は関節軟骨の厚みを増大させる
箭原 康人, 竹森 洋, 岡田 稔, 高才 東, 山下 晃弘, 小林 与人, 藤田 香里, 伊東 裕美, 中村 正裕, 渕野 裕之, 川原 信夫, 福井 尚志, 渡辺 亮, 木村 友厚, 妻木 範行
日本整形外科学会雑誌 Vol. 90 No. 8 p. S1487-S1487 2016/08 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki
NATURE COMMUNICATIONS Vol. 7 2016/03 Research paper (scientific journal)
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iPS細胞を用いた軟骨疾患に対する再生医療開発
山下晃弘, 妻木範行
月刊糖尿病 Vol. 8 No. 6 p. 91-97 2016 Part of collection (book)
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椎間板変性メカニズムと再生への架け橋 椎間板変性抑制を目指した治療標的因子
関 庄二, 牧野 紘士, 箭原 康人, 元村 拓, 野上 真紀子, 渡邉 健太, 塩沢 俊一, 淺沼 由美子, 舛田 浩一, 妻木 範行, 木村 友厚
日本整形外科学会雑誌 Vol. 89 No. 8 p. S1522-S1522 2015/09 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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変形性関節症性変化におけるSik3の役割
箭原 康人, 木村 友厚, 妻木 範行
日本整形外科学会雑誌 Vol. 89 No. 8 p. S1712-S1712 2015/09 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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選択的c-Fos/AP-1阻害薬によるマウスの椎間板変性抑制効果
箭原 康人, 関 庄二, 牧野 紘士, 塩沢 俊一, 妻木 範行, 木村 友厚
日本整形外科学会雑誌 Vol. 89 No. 8 p. S1782-S1782 2015/09 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes
Yumi Itoh, Masato Sanosaka, Hiroyuki Fuchino, Yasuhito Yahara, Ayako Kumagai, Daisaku Takemoto, Mai Kagawa, Junko Doi, Miho Ohta, Noriyuki Tsumaki, Nobuo Kawahara, Hiroshi Takemori
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 290 No. 29 p. 17879-17893 2015/07 Research paper (scientific journal)
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【ロコモティブシンドロームのすべて】ロコモティブシンドロームの基礎 運動器を構成する組織 軟骨
妻木 範行, 箭原 康人
日本医師会雑誌 Vol. 144 No. 特別1 p. S53-S55 2015/06
Publisher: (公社)日本医師会
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Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs
Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki
STEM CELL REPORTS Vol. 4 No. 3 p. 404-418 2015/03 Research paper (scientific journal)
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小児疾患の新規治療開発ーiPS細胞の有用性
妻木範行, 山下晃弘, 岡田稔
骨と腎代謝 Vol. 28 No. 3 p. 241-247 2015 Part of collection (book)
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ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成
山下晃弘, 妻木範行
日本再生医療学会 Vol. 14 No. 4 p. 70-74 2015 Research paper (conference, symposium, etc.)
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iPS cell technologies and cartilage regeneration
Noriyuki Tsumaki, Minoru Okada, Akihiro Yamashita
BONE Vol. 70 p. 48-54 2015/01 Research paper (scientific journal)
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Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells
Minoru Okada, Shiro Ikegawa, Miho Morioka, Akihiro Yamashita, Atsushi Saito, Hideaki Sawai, Jun Murotsuki, Hirofumi Ohashi, Toshio Okamoto, Gen Nishimura, Kazunori Imaizumi, Noriyuki Tsumaki
HUMAN MOLECULAR GENETICS Vol. 24 No. 2 p. 299-313 2015/01 Research paper (scientific journal)
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Cell reprogramming for skeletal dysplasia drug repositioning
Peter Karagiannis, Noriyuki Tsumaki
CELL CYCLE Vol. 13 No. 24 p. 3791-3792 2014/12 Research paper (scientific journal)
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Cyp26b1 within the growth plate regulates bone growth in juvenile mice
Yoshiki Minegishi, Yasuo Sakai, Yasuhito Yahara, Haruhiko Akiyama, Hideki Yoshikawa, Ko Hosokawa, Noriyuki Tsumaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 454 No. 1 p. 12-18 2014/11 Research paper (scientific journal)
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Statin treatment rescues FGFR3 skeletal dysplasia phenotypes
Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki
NATURE Vol. 513 No. 7519 p. 507-+ 2014/09 Research paper (scientific journal)
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マウスOAモデルにおける関節軟骨細胞分化の解析
箭原 康人, 木村 友厚, 妻木 範行
日本整形外科学会雑誌 Vol. 88 No. 8 p. S1423-S1423 2014/08 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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Cartilage intermediate layer protein promotes lumbar disc degeneration
Shoji Seki, Noriyuki Tsumaki, Hiraku Motomura, Makiko Nogami, Yoshiharu Kawaguchi, Takeshi Hori, Kayo Suzuki, Yasuhito Yahara, Mami Higashimoto, Takeshi Oya, Shiro Ikegawa, Tomoatsu Kimura
Biochemical and Biophysical Research Communications Vol. 446 No. 4 p. 876-881 2014/04/18 Research paper (scientific journal)
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Sox9 Reprogrammed Dermal Fibroblasts Undergo Hypertrophic Differentiation In Vitro and Trigger Endochondral Ossification In Vivo
Wai Long Tam, F. O. Dorien, Kunihiko Hiramatsu, Noriyuki Tsumaki, Frank P. Luyten, Scott J. Roberts
CELLULAR REPROGRAMMING Vol. 16 No. 1 p. 29-39 2014/02 Research paper (scientific journal)
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Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters
Y. Minegishi, K. Hosokawa, N. Tsumaki
OSTEOARTHRITIS AND CARTILAGE Vol. 21 No. 12 p. 1968-1975 2013/12 Research paper (scientific journal)
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Direct Induction of Chondrogenic Cells from Human Dermal Fibroblast Culture by Defined Factors
Hidetatsu Outani, Minoru Okada, Akihiro Yamashita, Kanako Nakagawa, Hideki Yoshikawa, Noriyuki Tsumaki
PLoS ONE Vol. 8 No. 10 2013/10/16 Research paper (scientific journal)
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iPS細胞を使うー軟骨の研究へ
妻木範行, 岡田稔, 山下晃弘
整形外科 Vol. 64 No. 10 p. 1106-1109 2013 Part of collection (book)
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iPS細胞由来軟骨細胞を用いた再生治療開発
山下晃弘, 妻木範行
Phama Medica Vol. 31 No. 4 p. 29-32 2013 Part of collection (book)
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Stem cell aging and the implications for stem cell-based therapies for aging-related diseases and aged tissues
Fujita K, Tsumaki N
Clin Calcium. Vol. 23 p. 65-73 2013/01 Part of collection (book)
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Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification
Riko Nishimura, Makoto Wakabayashi, Kenji Hata, Takuma Matsubara, Shiho Honma, Satoshi Wakisaka, Hiroshi Kiyonari, Go Shioi, Akira Yamaguchi, Noriyuki Tsumaki, Haruhiko Akiyama, Toshiyuki Yoneda
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 287 No. 40 p. 33179-33190 2012/09 Research paper (scientific journal)
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Sp1ファミリーの転写因子は骨肉腫由来骨芽細胞様細胞株においてXI型コラーゲンα2鎖遺伝子の転写活性を制御する
箭原 康人, 松井 好人, 東元 真実, 鈴木 賀代, 妻木 範行, 木村 友厚
日本整形外科学会雑誌 Vol. 86 No. 8 p. S1385-S1385 2012/08 Research paper (conference, symposium, etc.)
Publisher: (公社)日本整形外科学会
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An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene
Kohji Miura, Noriyuki Namba, Makoto Fujiwara, Yasuhisa Ohata, Hidekazu Ishida, Taichi Kitaoka, Takuo Kubota, Haruhiko Hirai, Chikahisa Higuchi, Noriyuki Tsumaki, Hideki Yoshikawa, Norio Sakai, Toshimi Michigami, Keiichi Ozono
PLOS ONE Vol. 7 No. 8 2012/08 Research paper (scientific journal)
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Sp1、3、7/Osterixは様々な骨肉腫由来細胞株においてCOL11A2の転写活性を制御する
箭原 康人, 松井 好人, 東元 真実, 鈴木 賀代, 妻木 範行, 木村 友厚
日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 Vol. 44回・59回 p. 60-60 2012/06 Research paper (conference, symposium, etc.)
Publisher: 日本結合組織学会・マトリックス研究会
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Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
Tatsuya Uebi, Yumi Itoh, Osamu Hatano, Ayako Kumagai, Masato Sanosaka, Tsutomu Sasaki, Satoru Sasagawa, Junko Doi, Keita Tatsumi, Kuniko Mitamura, Eiichi Morii, Katsuyuki Aozasa, Tomohiro Kawamura, Meinoshin Okumura, Jun Nakae, Hajime Takikawa, Toshio Fukusato, Minako Koura, Mayumi Nish, Anders Hamsten, Angela Silveira, Alejandro M. Bertorello, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Takeshi Tomonaga, Tetsuji Naka, Shigeo Ikegawa, Noriyuki Tsumaki, Junichiro Matsuda, Hiroshi Takemori
PLOS ONE Vol. 7 No. 5 2012/05 Research paper (scientific journal)
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SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
Satoru Sasagawa, Hiroshi Takemori, Tatsuya Uebi, Daisuke Ikegami, Kunihiko Hiramatsu, Shiro Ikegawa, Hideki Yoshikawa, Noriyuki Tsumaki
Development Vol. 139 No. 6 p. 1153-1163 2012/03 Research paper (scientific journal)
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Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice
Mina Okamoto, Junko Murai, Yuuki Imai, Daisuke Ikegami, Nobuhiro Kamiya, Shigeaki Kato, Yuji Mishina, Hideki Yoshikawa, Noriyuki Tsumaki
JOURNAL OF BONE AND MINERAL RESEARCH Vol. 26 No. 10 p. 2511-2522 2011/10 Research paper (scientific journal)
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Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state
Hidetatsu Outani, Minoru Okada, Kunihiko Hiramatsu, Hideki Yoshikawa, Noriyuki Tsumaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 411 No. 3 p. 607-612 2011/08 Research paper (scientific journal)
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ナトリウム利尿ペプチド受容体Bの機能獲得型変異はヒトおよびマウスにおいて成長促進と低骨密度をもたらす
三浦 弘司, 難波 範行, 藤原 誠, 北岡 太一, 大幡 泰久, 平井 治彦, 大薗 恵一, 樋口 周久, 妻木 範行, 吉川 秀樹, 道上 敏美
日本骨代謝学会学術集会プログラム抄録集 Vol. 29回 p. 180-180 2011/07 Research paper (conference, symposium, etc.)
Publisher: (一社)日本骨代謝学会
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Expression of dominant negative TGF-beta receptors inhibits cartilage formation in conditional transgenic mice
Kunihiko Hiramatsu, Takao Iwai, Hideki Yoshikawa, Noriyuki Tsumaki
JOURNAL OF BONE AND MINERAL METABOLISM Vol. 29 No. 4 p. 493-500 2011/07 Research paper (scientific journal)
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Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways
Daisuke Ikegami, Haruhiko Akiyama, Akira Suzuki, Takashi Nakamura, Toru Nakano, Hideki Yoshikawa, Noriyuki Tsumaki
DEVELOPMENT Vol. 138 No. 8 p. 1507-1519 2011/04 Research paper (scientific journal)
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Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25
Yukio Nakamura, Koji Yamamoto, Xinjun He, Bungo Otsuki, Youngwoo Kim, Hiroki Murao, Tsunemitsu Soeda, Noriyuki Tsumaki, Jian Min Deng, Zhaoping Zhang, Richard R. Behringer, Benoit de Crombrugghe, John H. Postlethwait, Matthew L. Warman, Takashi Nakamura, Haruhiko Akiyama
NATURE COMMUNICATIONS Vol. 2 2011/03 Research paper (scientific journal)
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Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage
D. Ikegami, T. Iwai, S. Ryo, N. Gu, T. Sugiyama, I. Oh, H. Yoshikawa, N. Tsumaki
OSTEOARTHRITIS AND CARTILAGE Vol. 19 No. 2 p. 233-241 2011/02 Research paper (scientific journal)
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Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors
Kunihiko Hiramatsu, Satoru Sasagawa, Hidetatsu Outani, Kanako Nakagawa, Hideki Yoshikawa, Noriyuki Tsumaki
JOURNAL OF CLINICAL INVESTIGATION Vol. 121 No. 2 p. 640-657 2011/02 Research paper (scientific journal)
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Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development
Dai Suzuki, Atsushi Yamada, Takanori Amano, Rika Yasuhara, Ayako Kimura, Mizuho Sakahara, Noriyuki Tsumaki, Shu Takeda, Masaru Tamura, Masanori Nakamura, Naoyuki Wada, Tsutomu Nohno, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamijo
DEVELOPMENTAL BIOLOGY Vol. 335 No. 2 p. 396-406 2009/11 Research paper (scientific journal)
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Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene. (vol 275, pg 12712, 2000)
Ying Liu, Haochuan Li, Kazuhiro Tanaka, Noriyuki Tsumaki, Yoshihiko Yamada
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 284 No. 17 p. 11748-11748 2009/04 Research paper (scientific journal)
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Generation of Rac1 conditional mutant mice by Cre/loxP system
Dai Suzuki, Atsushi Yamada, Takanori Amano, Ayako Kimura, Rika Yasuhara, Mizuho Sakahara, Masaru Tamura, Noriyuki Tsumaki, Shu Takeda, Masanori Nakamura, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamijo
TRANSMITTERS AND MODULATORS IN HEALTH AND DISEASE p. 175-+ 2009 Research paper (international conference proceedings)
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Bone biology: Development and regeneration mechanisms in physiological and pathological conditions
Hideki Yoshikawa, Noriyuki Tsumaki, Akira Myoui
Strategies in Regenerative Medicine: Integrating Biology with Materials Design p. 431-448 2009 Part of collection (book)
Publisher: Springer New York
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Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2
Junko Murai, Daisuke Ikegami, Mina Okamoto, Hideki Yoshikawa, Noriyuki Tsumaki
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 41 p. 27677-27687 2008/10 Research paper (scientific journal)
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Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways
Takao Iwai, Junko Murai, Hideki Yoshikawa, Noriyuki Tsumaki
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 40 p. 27154-27164 2008/10 Research paper (scientific journal)
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Characteristics of fracture and related factors in patients with rheumatoid arthritis
Akihide Nampei, Jun Hashimoto, Junichiro Koyanagi, Takeshi Ono, Hideo Hashimoto, Noriyuki Tsumaki, Tetsuya Tomita, Kazuomi Sugamoto, Norihiro Nishimoto, Takahiro Ochi, Hideki Yoshikawa
MODERN RHEUMATOLOGY Vol. 18 No. 2 p. 170-176 2008/04 Research paper (scientific journal)
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Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic
Iwai, Takao, Harada, Yoshifumi, Imura, Koichi, Iwabuchi, Sadahiro, Murai, Junko, Hiramatsu, Kunihiko, Myoui, Akira, Yoshikawa, Hideki, Tsumaki, Noriyuki
JOURNAL OF BONE AND MINERAL METABOLISM Vol. 25 No. 6 p. 392-399 2007/11 Research paper (scientific journal)
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Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts
Tadashi Sugiki, Taro Uyama, Masashi Toyoda, Hideo Morioka, Shoen Kume, Kenji Miyado, Kenji Matsumoto, Hirohisa Saito, Noriyuki Tsumaki, Yoriko Takahashi, Yoshiaki Toyama, Akihiro Umezawa
JOURNAL OF CELLULAR BIOCHEMISTRY Vol. 100 No. 5 p. 1240-1254 2007/04 Research paper (scientific journal)
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Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification
Makoto Hirao, Noriyuki Tamai, Noriyuki Tsumaki, Hideki Yoshikawa, Akira Myoui
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 281 No. 41 p. 31079-31092 2006/10 Research paper (scientific journal)
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Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development
M Okamoto, J Murai, H Yoshikawa, N Tsumaki
JOURNAL OF BONE AND MINERAL RESEARCH Vol. 21 No. 7 p. 1022-1033 2006/07 Research paper (scientific journal)
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[Bone morphogenetic proteins and their related molecules in the skeletal tissue].
Tsumaki N, Yoshikawa H
Clinical calcium Vol. 16 No. 5 p. 787-792 2006/05 Part of collection (book)
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[Roles of BMPs during endochondral bone formation].
Iwai T, Tsumaki N, Yoshikawa H
Nihon rinsho. Japanese journal of clinical medicine Vol. 63 Suppl 10 p. 431-434 2005/10 Research paper (conference, symposium, etc.)
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The role of bone morphogenetic proteins in endochondral bone formation
N Tsumaki, H Yoshikawa
CYTOKINE & GROWTH FACTOR REVIEWS Vol. 16 No. 3 p. 279-285 2005/06 Research paper (scientific journal)
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Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis
N Tsumaki, M Kakiuchi, J Sasaki, T Ochi, H Yoshikawa
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME Vol. 86A No. 11 p. 2399-2405 2004/11 Research paper (scientific journal)
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Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow
R Katayama, S Wakitani, N Tsumaki, Y Morita, Matsushita, I, R Gejo, T Kimura
RHEUMATOLOGY Vol. 43 No. 8 p. 980-985 2004/08 Research paper (scientific journal)
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[Role of BMPs and Smads during endochondral bone formation].
Tsumaki N, Horiki M, Murai J, Yoshikawa H
Clinical calcium Vol. 14 No. 7 p. 52-57 2004/07 Part of collection (book)
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Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia
M Horiki, T Imamura, M Okamoto, M Hayashi, J Murai, A Myoui, T Ochi, K Miyazono, H Yoshikawa, N Tsumaki
JOURNAL OF CELL BIOLOGY Vol. 165 No. 3 p. 433-445 2004/05 Research paper (scientific journal)
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低リン血症性骨軟化症を併発したと考えられる関節リウマチの1例
牧野 孝洋, 橋本 淳, 橋本 英雄, 妻木 範行, 冨田 哲也, 菅本 一臣, 吉川 秀樹
中部日本整形外科災害外科学会雑誌 Vol. 47 No. 2 p. 375-376 2004/03 Research paper (conference, symposium, etc.)
Publisher: 中部日本整形外科災害外科学会
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COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG
Y Matsui, HA Chansky, F Barahmand-Pour, A Zielinska-Kwiatkowska, N Tsumaki, A Myoui, H Yoshikawa, L Yang, DR Eyre
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 13 p. 11369-11375 2003/03 Research paper (scientific journal)
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Cartilage-specific overexpression of C-propeptide of type II collagen affected matrix mineralization in transgenic mice
Y. Matsui, K. Nakata, E. Adachi, N. Tsumaki, T. Kimura, N. Yasui, E. Kataoka, Y. Fujita, H. Tsuboi, H. Yoshikawa
Journal of Musculoskeletal Research Vol. 7 No. 3-4 p. 183-189 2003 Research paper (scientific journal)
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Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells
Y Matsui, N Araki, H Tsuboi, N Tsumaki, K Nakata, H Kawabata, DR Eyre, H Yoshikawa
ANTICANCER RESEARCH Vol. 22 No. 6C p. 4169-4172 2002/11 Research paper (scientific journal)
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Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis
N Tsumaki, T Nakase, T Miyaji, M Kakiuchi, T Kimura, T Ochi, H Yoshikawa
JOURNAL OF BONE AND MINERAL RESEARCH Vol. 17 No. 5 p. 898-906 2002/05 Research paper (scientific journal)
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Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff
Takanobu Nakase, Kazuomi Sugamoto, Takashi Miyamoto, Noriyuki Tsumaki, Frank P. Luyten, Hiroaki Inui, Akira Myoui, Tetsuya Tomita, Hideki Yoshikawa
Clinical Orthopaedics and Related Research No. 399 p. 140-145 2002 Research paper (scientific journal)
Publisher: Lippincott Williams and Wilkins
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Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum
T Nakase, K Ariga, K Yonenobu, N Tsumaki, FP Luyten, Y Mukai, Sato, I, H Yoshikawa
EUROPEAN SPINE JOURNAL Vol. 10 No. 4 p. 289-294 2001/08 Research paper (scientific journal)
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Alternative splicing of fibronectin transcripts in osteochondrogenic tumors
Y Matsui, K Nakata, N Araki, K Ozono, Y Fujita, N Tsumaki, H Kawabata, N Yasui, K Sekiguchi, H Yoshikawa
ANTICANCER RESEARCH Vol. 21 No. 2A p. 1103-1106 2001/03 Research paper (scientific journal)
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Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene
Y Liu, HC Li, K Tanaka, N Tsumaki, Y Yamada
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 17 p. 12712-12718 2000/04 Research paper (scientific journal)
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Enhancer analysis of the alpha 1(II) and alpha 2(XI) collagen genes in transfected chondrocytes and transgenic mice.
N. Tsumaki, Y. Liu, Y. Yamada, P. Krebsbach
Methods in molecular biology (Clifton, N.J.) Vol. 139 p. 187-195 2000 Part of collection (book)
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A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia
Y Matsui, N Yasui, H Kawabata, K Ozono, K Nakata, T Mizushima, N Tsumaki, E Kataoka, Y Fujita, T Ochi
JOURNAL OF HUMAN GENETICS Vol. 45 No. 2 p. 105-108 2000 Research paper (scientific journal)
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Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation
N Tsumaki, K Tanaka, E Arikawa-Hirasawa, T Nakase, T Kimura, JT Thomas, T Ochi, FP Luyten, Y Yamada
JOURNAL OF CELL BIOLOGY Vol. 144 No. 1 p. 161-173 1999/01 Research paper (scientific journal)
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Genotype phenotype correlation in achondroplasia and hypochondroplasia
Y Matsui, N Yasui, T Kimura, N Tsumaki, H Kawabata, T Ochi
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME Vol. 80B No. 6 p. 1052-1056 1998/11 Research paper (scientific journal)
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Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha 2(XI) collagen promoter
N Tsumaki, T Kimura, K Tanaka, JH Kimura, T Ochi, Y Yamada
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 36 p. 22861-22864 1998/09 Research paper (scientific journal)
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Differential in situ expression of alpha 2(XI) collagen mRNA isoforms in the developing mouse
M Sugimoto, T Kimura, N Tsumaki, Y Matsui, K Nakata, H Kawahata, N Yasui, Y Kitamura, S Nomura, T Ochi
CELL AND TISSUE RESEARCH Vol. 292 No. 2 p. 325-332 1998/05 Research paper (scientific journal)
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Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors
Y Matsui, T Kimura, N Tsumaki, K Nakata, N Yasui, N Araki, N Hashimoto, A Uchida, T Ochi
CANCER LETTERS Vol. 124 No. 2 p. 143-148 1998/02 Research paper (scientific journal)
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A recurrent 1992delCT mutation of the type X collagen gene in a Japanese patient with Schmid metaphyseal chondrodysplasia
Y Matsui, T Kimura, N Tsumaki, N Yasui, T Ochi
JAPANESE JOURNAL OF HUMAN GENETICS Vol. 41 No. 3 p. 339-342 1996/09 Research paper (scientific journal)
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Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage
N Tsumaki, T Kimura, Y Matsui, K Nakata, T Ochi
JOURNAL OF CELL BIOLOGY Vol. 134 No. 6 p. 1573-1582 1996/09 Research paper (scientific journal)
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Cervical spondylotic radiculopathy involving two adjacent nerve roots - Anterior decompression through a single level intervertebral approach
M Iwasaki, K Okada, N Tsumaki, H Obata, N Shirasaki, S Oka
INTERNATIONAL ORTHOPAEDICS Vol. 20 No. 3 p. 137-141 1996/06 Research paper (scientific journal)
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Progressive degeneration of articular cartilage and intervertebral discs - An experimental study in transgenic mice bearing a type IX collagen mutation
T Kimura, K Nakata, N Tsumaki, S Miyamoto, Y Matsui, S Ebara, T Ochi
INTERNATIONAL ORTHOPAEDICS Vol. 20 No. 3 p. 177-181 1996/06 Research paper (scientific journal)
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Separable regulatory elements from pro-alpha 2(XI) collagen gene drive distinct patterns of cartilage-specific expression in transgenic mice
N Tsumaki, M Sugimoto, K Nakata, Y Matsui, T Ochi, T Kimura
MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE Vol. 785 p. 340-342 1996 Research paper (international conference proceedings)
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DIFFERENTIAL EXPRESSION OF AN ACIDIC DOMAIN IN THE AMINO-TERMINAL PROPEPTIDE OF MOUSE PRO-ALPHA-2(XI) COLLAGEN BY COMPLEX ALTERNATIVE SPLICING
N TSUMAKI, T KIMURA
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 270 No. 5 p. 2372-2378 1995/02
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ALTERED CHONDROCYTE GENE-EXPRESSION IN ARTICULAR-CARTILAGE MATRIX COMPONENTS AND SUSCEPTIBILITY TO CARTILAGE DESTRUCTION
T KIMURA, K NAKATA, N TSUMAKI, K ONO
CELL MECHANICS AND CELLULAR ENGINEERING p. 445-456 1994 Part of collection (book)