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Noriyuki Tsumaki
妻木 範行
Noriyuki Tsumaki
妻木 範行
Graduate School of Frontier Biosciences Department of Frontier Biosciences, Professor

keyword Regenerative medicine,軟骨代謝

Research History 9

  1. 2021/07 - Present
    Graduate School of Medicine, Osaka University Department of Biochemistry and Molecular Biology Professor

  2. 2011/06 - Present
    Kyoto University

  3. 2007/04 - 2011/05
    Osaka University Graduate School of Medicine

  4. 2002/08 - 2007/03
    大阪大学大学院 医学系研究科 整形外科 助手

  5. 1999/04 - 2002/07
    大阪警察病院 整形外科 副医長

  6. 1998/01 - 1999/03
    Osaka University Faculty of Medicine

  7. 1996/06 - 1998/01
    米国国立保健研究所(NIH) Visiting fellow

  8. 1996/04 - 1996/05
    Osaka University Faculty of Medicine

  9. 1989/05 - 1992/03
    Osaka University Hospital

Education 3

  1. 大阪大学大学院 医学研究科博士課程

    1992/04 - 1996/03

  2. Osaka University Graduate School, Division of Medicine

    - 1996

  3. Osaka University Faculty of Medicine Medical School

    1983/04 - 1989/03

Professional Memberships 8

  1. The American Society for Bone and Mineral Research

  2. 米国骨代謝学会

  3. 日本結合組織学会

  4. 日本軟骨代謝学会

  5. 日本骨代謝学会

  6. 日本リウマチ学会

  7. 日本整形外科学会

  8. The American Society for Bone and Mineral Research

Research Areas 1

  1. Life sciences / Functional biochemistry /

Awards 6

  1. 日本骨代謝学会研究奨励賞

    2008

  2. 日本骨代謝学会優秀演題賞

    2000

  3. 日本整形外科学会奨励賞

    2000

  4. 日本骨代謝学会優秀演題賞

    1998

  5. 日本結合組織学会賞

    1997

  6. 日本軟骨代謝学会賞

    1996

Papers 116

  1. iPS Cell-Based Technology for Joint Resurfacing

    Takahiro Negishi, Noriyuki Tsumaki

    Regenerative Medicine in Sports and Orthopaedics p. 425-434 2025/04/29 Part of collection (book)

    Publisher: Springer Nature Switzerland
  2. SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response to Exogenous Gonadotropins In Vivo

    Emily T Hayes, Mariam Hassan, Oliwia Lakomy, Rachael Filzen, Marah Armouti, Marc Foretz, Noriyuki Tsumaki, Hiroshi Takemori, Carlos Stocco

    Endocrinology Vol. 165 No. 10 2024/08/19 Research paper (scientific journal)

    Publisher: The Endocrine Society
  3. Subpopulations of fibroblasts derived from human iPS cells

    Takashi Kobayashi, Akihiro Yamashita, Noriyuki Tsumaki, Hideto Watanabe

    Communications Biology Vol. 7 No. 1 2024/06/18 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  4. Regenerative therapy for articular cartilage damage using iPS cell technology.

    妻木範行

    生産と技術 Vol. 76 No. 1 2024

  5. Development of regenerative treatment using iPS cell-derived cartilage organoid

    妻木範行, 妻木範行

    実験医学 Vol. 42 No. 5 2024

  6. Strategies for Developing Regenerative Therapies for Articular Cartilage Damage

    妻木範行, 妻木範行, 妻木範行

    臨床整形外科 Vol. 59 No. 3 2024

  7. これならわかる骨系統疾患とその周辺 iPS細胞からの軟骨細胞誘導法と疾患iPS細胞モデル

    妻木範行, 妻木範行, 妻木範行

    周産期医学 Vol. 54 No. 12 2024

  8. 人工臓器-最近の進歩 関節における人工臓器の開発研究:iPS細胞由来軟骨を用いた関節軟骨の構成

    妻木範行, 妻木範行, 妻木範行

    人工臓器(日本人工臓器学会) Vol. 53 No. 3 2024

  9. Destruction and regeneration in bone and cartilage

    Noriyuki Tsumaki

    Inflammation and Regeneration Vol. 43 No. 1 2023/12/13 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  10. Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity

    Kengo Abe, Noriyuki Tsumaki

    Inflammation and Regeneration Vol. 43 No. 1 2023/11/14 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  11. Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles

    Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, Noriyuki Tsumaki, Norimasa Nakamura

    npj Regenerative Medicine Vol. 8 No. 1 2023/10/19 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  12. Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone

    Hiroki Hagizawa, Saeko Koyamatsu, Seiji Okada, Takashi Kaito, Noriyuki Tsumaki

    Frontiers in Cell and Developmental Biology Vol. 11 2023/05/15 Research paper (scientific journal)

    Publisher: Frontiers Media SA
  13. Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

    Kengo Abe, Akihiro Yamashita, Miho Morioka, Nanao Horike, Yoshiaki Takei, Saeko Koyamatsu, Keisuke Okita, Shuichi Matsuda, Noriyuki Tsumaki

    Nature Communications Vol. 14 No. 1 2023/02/20 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  14. 低血清および低酸素条件下におけるiPS細胞由来軟骨細胞シートの硝子軟骨修復能の向上

    内山 綾香, 佐藤 正人, 高橋 匠, 豊田 恵利子, 前原 美樹, 大村 はるか, 小川 真梨奈, 森岡 美帆, 山下 晃弘, 渡辺 雅彦, 妻木 範行

    日本整形外科学会雑誌 Vol. 96 No. 8 p. S1556-S1556 2022/09

    Publisher: (公社)日本整形外科学会
  15. Universal Surface Biotinylation: a simple, versatile and cost-effective sample multiplexing method for single-cell RNA-seq analysis

    Michihiko Sugimoto, Yuhki Tada, Shigeyuki Shichino, Saeko Koyamatsu, Noriyuki Tsumaki, Kuniya Abe

    DNA Research Vol. 29 No. 3 2022/05/27 Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)
  16. Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus

    Takashi Kamatani, Hiroki Hagizawa, Seido Yarimitsu, Miho Morioka, Saeko Koyamatsu, Michihiko Sugimoto, Joe Kodama, Junko Yamane, Hiroyuki Ishiguro, Shigeyuki Shichino, Kuniya Abe, Wataru Fujibuchi, Hiromichi Fujie, Takashi Kaito, Noriyuki Tsumaki

    Biomaterials Vol. 284 p. 121491-121491 2022/05 Research paper (scientific journal)

    Publisher: Elsevier BV
  17. Generation of monkey iPS cell-derived cartilage lacking MHC class I molecules on the cell surface

    Okutani, Yuki, Abe, Kengo, Yamashita, Akihiro, Morioka, Miho, Matsuda, Shuichi, Tsumaki, Noriyuki

    Tissue Engineering Part A Vol. 28 No. 1-2 p. 94-106 2022/01 Research paper (scientific journal)

  18. Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects

    Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts, Frank P. Luyten

    Stem Cell Research & Therapy Vol. 12 No. 1 2021/12 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  19. Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice.

    Yuki Iimori, Miho Morioka, Saeko Koyamatsu, Noriyuki Tsumaki

    Tissue engineering. Part A Vol. 27 No. 21-22 p. 1355-1367 2021/08/16 Research paper (scientific journal)

  20. Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells

    Akihiro Yamashita, Noriyuki Tsumaki

    Development, Growth & Differentiation Vol. 63 No. 1 p. 72-81 2021/01 Research paper (scientific journal)

    Publisher: Wiley
  21. Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.

    Akihiro Yamashita, Hiroyuki Yoshitomi, Shunsuke Kihara, Junya Toguchida, Noriyuki Tsumaki

    Stem cells translational medicine Vol. 10 No. 1 p. 115-127 2021/01 Research paper (scientific journal)

  22. Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.

    Tomonori Ozaki, Tatsuya Kawamoto, Yuki Iimori, Nobuaki Takeshita, Yukiko Yamagishi, Hiroaki Nakamura, Masazumi Kamohara, Kaori Fujita, Masayuki Tanahashi, Noriyuki Tsumaki

    Scientific reports Vol. 10 No. 1 p. 20915-20915 2020/12/01 Research paper (scientific journal)

  23. Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage

    Yoshiaki Takei, Miho Morioka, Akihiro Yamashita, Tomohito Kobayashi, Nobuyuki Shima, Noriyuki Tsumaki

    Scientific Reports Vol. 10 No. 1 2020/07/30 Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC
  24. Visualization of human iPS cells-derived 3D cartilage tissue by gelatin nanospheres.

    Yuki Murata, Jun-Ichiro Jo, Hiroshi Yukawa, Noriyuki Tsumaki, Yoshinobu Baba, Yasuhiko Tabata

    Tissue engineering. Part C, Methods Vol. 26 No. 5 p. 244-252 2020/03/06 Research paper (scientific journal)

  25. Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.

    Kosai A, Horike N, Takei Y, Yamashita A, Fujita K, Kamatani T, Tsumaki N

    Biochem Biophys Res Commun. Vol. 516 No. 4 p. 1097-1102 2019/09 Research paper (scientific journal)

  26. 量子ドット・磁性ナノ粒子含有ゼラチンナノ粒子を用いたヒトiPS細胞由来3次元軟骨組織の可視化

    城 潤一郎, 村田 勇樹, 湯川 博, 妻木 範行, 馬場 嘉信, 田畑 泰彦

    JSMI Report Vol. 12 No. 2 p. 123-123 2019/05 Research paper (conference, symposium, etc.)

    Publisher: 日本分子イメージング学会
  27. Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia

    Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N

    Osteoarthritis and Cartilage Vol. 26 No. 11 p. 1551-1561 2018/11 Research paper (scientific journal)

  28. Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.

    Chen X, Yamashita A, Morioka M, Senba T, Kamatani T, Watanabe A, Kosai A, Tsumaki N

    Tissue engineering. Part A Vol. 25 No. 5-6 p. 437-445 2018/10 Research paper (scientific journal)

  29. 椎間板変性および椎間板関連の疼痛に対する選択的c-Fos/AP-1阻害の治療効果

    牧野 紘士, 関 庄二, 箭原 康人, 塩沢 俊一, 妻木 範行, 木村 友厚

    中部日本整形外科災害外科学会雑誌 Vol. 61 No. 秋季学会 p. 261-261 2018/09 Research paper (conference, symposium, etc.)

    Publisher: (一社)中部日本整形外科災害外科学会
  30. 運動器疾患に対するiPS細胞研究の進歩 関節軟骨欠損に対するiPS細胞由来軟骨を用いた治療について

    小林 与人, 武井 義明, 山下 晃弘, 森岡 美帆, 釜谷 崇志, 高才 東, Woltjen Knut, 松田 秀一, 妻木 範行

    日本整形外科学会雑誌 Vol. 92 No. 8 p. S1938-S1938 2018/08 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  31. 骨代謝と病気の新たなクロストーク:臓器連関から創薬まで 疾患特異的ヒトiPS細胞を用いた成長板軟骨モデルの確立と創薬への応用

    木村 武司, 尾崎 友則, 藤田 香里, 山下 晃弘, 森岡 美穂, 大薗 恵一, 妻木 範行

    日本骨代謝学会学術集会プログラム抄録集 Vol. 36回 p. 115-115 2018/07 Research paper (conference, symposium, etc.)

    Publisher: (一社)日本骨代謝学会
  32. 【腰痛治療の革新-慢性腰痛・神経障害性疼痛に対する治療のbreakthrough】椎間板変性抑制と椎間板再生を目指した治療標的因子

    関 庄二, 牧野 紘士, 箭原 康人, 塩沢 俊一, 妻木 範行, 木村 友厚

    Journal of Spine Research Vol. 9 No. 6 p. 1017-1021 2018/06 Research paper (conference, symposium, etc.)

    Publisher: (一社)日本脊椎脊髄病学会
  33. Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.

    Hiroki Goto, Miki Nishio, Yoko To, Tatsuya Oishi, Yosuke Miyachi, Tomohiko Maehama, Hiroshi Nishina, Haruhiko Akiyama, Tak Wah Mak, Yuma Makii, Taku Saito, Akihiro Yasoda, Noriyuki Tsumaki, Akira Suzuki

    Development (Cambridge, England) Vol. 145 No. 6 2018/03/16 Research paper (scientific journal)

  34. A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation

    Tomohito Kobayashi, Kaori Fujita, Takashi Kamatani, Shuichi Matsuda, Noriyuki Tsumaki

    Biochemical and Biophysical Research Communications Vol. 495 No. 1 p. 1468-1475 2018/01/01 Research paper (scientific journal)

    Publisher: Elsevier B.V.
  35. Considerations in hiPSC-derived cartilage for articular cartilage repair.

    Yamashita A, Tamamura Y, Morioka M, Karagiannis P, Shima N, Tsumaki N

    Inflammation and regeneration Vol. 38 p. 17-17 2018 Research paper (scientific journal)

  36. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain

    Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimura

    SCIENTIFIC REPORTS Vol. 7 No. 1 2017/12 Research paper (scientific journal)

  37. Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages

    Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki

    TISSUE ENGINEERING PART A Vol. 22 No. 23-24 p. 1367-1375 2016/12 Research paper (scientific journal)

  38. 軟骨細胞特異的なSik3の欠失は関節軟骨の厚みを増大させる

    箭原 康人, 竹森 洋, 岡田 稔, 高才 東, 山下 晃弘, 小林 与人, 藤田 香里, 伊東 裕美, 中村 正裕, 渕野 裕之, 川原 信夫, 福井 尚志, 渡辺 亮, 木村 友厚, 妻木 範行

    日本整形外科学会雑誌 Vol. 90 No. 8 p. S1487-S1487 2016/08 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  39. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

    Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki

    NATURE COMMUNICATIONS Vol. 7 2016/03 Research paper (scientific journal)

  40. iPS細胞を用いた軟骨疾患に対する再生医療開発

    山下晃弘, 妻木範行

    月刊糖尿病 Vol. 8 No. 6 p. 91-97 2016 Part of collection (book)

  41. 椎間板変性メカニズムと再生への架け橋 椎間板変性抑制を目指した治療標的因子

    関 庄二, 牧野 紘士, 箭原 康人, 元村 拓, 野上 真紀子, 渡邉 健太, 塩沢 俊一, 淺沼 由美子, 舛田 浩一, 妻木 範行, 木村 友厚

    日本整形外科学会雑誌 Vol. 89 No. 8 p. S1522-S1522 2015/09 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  42. 変形性関節症性変化におけるSik3の役割

    箭原 康人, 木村 友厚, 妻木 範行

    日本整形外科学会雑誌 Vol. 89 No. 8 p. S1712-S1712 2015/09 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  43. 選択的c-Fos/AP-1阻害薬によるマウスの椎間板変性抑制効果

    箭原 康人, 関 庄二, 牧野 紘士, 塩沢 俊一, 妻木 範行, 木村 友厚

    日本整形外科学会雑誌 Vol. 89 No. 8 p. S1782-S1782 2015/09 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  44. Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes

    Yumi Itoh, Masato Sanosaka, Hiroyuki Fuchino, Yasuhito Yahara, Ayako Kumagai, Daisaku Takemoto, Mai Kagawa, Junko Doi, Miho Ohta, Noriyuki Tsumaki, Nobuo Kawahara, Hiroshi Takemori

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 290 No. 29 p. 17879-17893 2015/07 Research paper (scientific journal)

  45. 【ロコモティブシンドロームのすべて】ロコモティブシンドロームの基礎 運動器を構成する組織 軟骨

    妻木 範行, 箭原 康人

    日本医師会雑誌 Vol. 144 No. 特別1 p. S53-S55 2015/06

    Publisher: (公社)日本医師会
  46. Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

    Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki

    STEM CELL REPORTS Vol. 4 No. 3 p. 404-418 2015/03 Research paper (scientific journal)

  47. 小児疾患の新規治療開発ーiPS細胞の有用性

    妻木範行, 山下晃弘, 岡田稔

    骨と腎代謝 Vol. 28 No. 3 p. 241-247 2015 Part of collection (book)

  48. ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成

    山下晃弘, 妻木範行

    日本再生医療学会 Vol. 14 No. 4 p. 70-74 2015 Research paper (conference, symposium, etc.)

  49. iPS cell technologies and cartilage regeneration

    Noriyuki Tsumaki, Minoru Okada, Akihiro Yamashita

    BONE Vol. 70 p. 48-54 2015/01 Research paper (scientific journal)

  50. Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells

    Minoru Okada, Shiro Ikegawa, Miho Morioka, Akihiro Yamashita, Atsushi Saito, Hideaki Sawai, Jun Murotsuki, Hirofumi Ohashi, Toshio Okamoto, Gen Nishimura, Kazunori Imaizumi, Noriyuki Tsumaki

    HUMAN MOLECULAR GENETICS Vol. 24 No. 2 p. 299-313 2015/01 Research paper (scientific journal)

  51. Cell reprogramming for skeletal dysplasia drug repositioning

    Peter Karagiannis, Noriyuki Tsumaki

    CELL CYCLE Vol. 13 No. 24 p. 3791-3792 2014/12 Research paper (scientific journal)

  52. Cyp26b1 within the growth plate regulates bone growth in juvenile mice

    Yoshiki Minegishi, Yasuo Sakai, Yasuhito Yahara, Haruhiko Akiyama, Hideki Yoshikawa, Ko Hosokawa, Noriyuki Tsumaki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 454 No. 1 p. 12-18 2014/11 Research paper (scientific journal)

  53. Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

    Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki

    NATURE Vol. 513 No. 7519 p. 507-+ 2014/09 Research paper (scientific journal)

  54. マウスOAモデルにおける関節軟骨細胞分化の解析

    箭原 康人, 木村 友厚, 妻木 範行

    日本整形外科学会雑誌 Vol. 88 No. 8 p. S1423-S1423 2014/08 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  55. Cartilage intermediate layer protein promotes lumbar disc degeneration

    Shoji Seki, Noriyuki Tsumaki, Hiraku Motomura, Makiko Nogami, Yoshiharu Kawaguchi, Takeshi Hori, Kayo Suzuki, Yasuhito Yahara, Mami Higashimoto, Takeshi Oya, Shiro Ikegawa, Tomoatsu Kimura

    Biochemical and Biophysical Research Communications Vol. 446 No. 4 p. 876-881 2014/04/18 Research paper (scientific journal)

  56. Sox9 Reprogrammed Dermal Fibroblasts Undergo Hypertrophic Differentiation In Vitro and Trigger Endochondral Ossification In Vivo

    Wai Long Tam, F. O. Dorien, Kunihiko Hiramatsu, Noriyuki Tsumaki, Frank P. Luyten, Scott J. Roberts

    CELLULAR REPROGRAMMING Vol. 16 No. 1 p. 29-39 2014/02 Research paper (scientific journal)

  57. Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters

    Y. Minegishi, K. Hosokawa, N. Tsumaki

    OSTEOARTHRITIS AND CARTILAGE Vol. 21 No. 12 p. 1968-1975 2013/12 Research paper (scientific journal)

  58. Direct Induction of Chondrogenic Cells from Human Dermal Fibroblast Culture by Defined Factors

    Hidetatsu Outani, Minoru Okada, Akihiro Yamashita, Kanako Nakagawa, Hideki Yoshikawa, Noriyuki Tsumaki

    PLoS ONE Vol. 8 No. 10 2013/10/16 Research paper (scientific journal)

  59. iPS細胞を使うー軟骨の研究へ

    妻木範行, 岡田稔, 山下晃弘

    整形外科 Vol. 64 No. 10 p. 1106-1109 2013 Part of collection (book)

  60. iPS細胞由来軟骨細胞を用いた再生治療開発

    山下晃弘, 妻木範行

    Phama Medica Vol. 31 No. 4 p. 29-32 2013 Part of collection (book)

  61. Stem cell aging and the implications for stem cell-based therapies for aging-related diseases and aged tissues

    Fujita K, Tsumaki N

    Clin Calcium. Vol. 23 p. 65-73 2013/01 Part of collection (book)

  62. Osterix Regulates Calcification and Degradation of Chondrogenic Matrices through Matrix Metalloproteinase 13 (MMP13) Expression in Association with Transcription Factor Runx2 during Endochondral Ossification

    Riko Nishimura, Makoto Wakabayashi, Kenji Hata, Takuma Matsubara, Shiho Honma, Satoshi Wakisaka, Hiroshi Kiyonari, Go Shioi, Akira Yamaguchi, Noriyuki Tsumaki, Haruhiko Akiyama, Toshiyuki Yoneda

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 287 No. 40 p. 33179-33190 2012/09 Research paper (scientific journal)

  63. Sp1ファミリーの転写因子は骨肉腫由来骨芽細胞様細胞株においてXI型コラーゲンα2鎖遺伝子の転写活性を制御する

    箭原 康人, 松井 好人, 東元 真実, 鈴木 賀代, 妻木 範行, 木村 友厚

    日本整形外科学会雑誌 Vol. 86 No. 8 p. S1385-S1385 2012/08 Research paper (conference, symposium, etc.)

    Publisher: (公社)日本整形外科学会
  64. An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

    Kohji Miura, Noriyuki Namba, Makoto Fujiwara, Yasuhisa Ohata, Hidekazu Ishida, Taichi Kitaoka, Takuo Kubota, Haruhiko Hirai, Chikahisa Higuchi, Noriyuki Tsumaki, Hideki Yoshikawa, Norio Sakai, Toshimi Michigami, Keiichi Ozono

    PLOS ONE Vol. 7 No. 8 2012/08 Research paper (scientific journal)

  65. Sp1、3、7/Osterixは様々な骨肉腫由来細胞株においてCOL11A2の転写活性を制御する

    箭原 康人, 松井 好人, 東元 真実, 鈴木 賀代, 妻木 範行, 木村 友厚

    日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 Vol. 44回・59回 p. 60-60 2012/06 Research paper (conference, symposium, etc.)

    Publisher: 日本結合組織学会・マトリックス研究会
  66. Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

    Tatsuya Uebi, Yumi Itoh, Osamu Hatano, Ayako Kumagai, Masato Sanosaka, Tsutomu Sasaki, Satoru Sasagawa, Junko Doi, Keita Tatsumi, Kuniko Mitamura, Eiichi Morii, Katsuyuki Aozasa, Tomohiro Kawamura, Meinoshin Okumura, Jun Nakae, Hajime Takikawa, Toshio Fukusato, Minako Koura, Mayumi Nish, Anders Hamsten, Angela Silveira, Alejandro M. Bertorello, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Takeshi Tomonaga, Tetsuji Naka, Shigeo Ikegawa, Noriyuki Tsumaki, Junichiro Matsuda, Hiroshi Takemori

    PLOS ONE Vol. 7 No. 5 2012/05 Research paper (scientific journal)

  67. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

    Satoru Sasagawa, Hiroshi Takemori, Tatsuya Uebi, Daisuke Ikegami, Kunihiko Hiramatsu, Shiro Ikegawa, Hideki Yoshikawa, Noriyuki Tsumaki

    Development Vol. 139 No. 6 p. 1153-1163 2012/03 Research paper (scientific journal)

  68. Conditional Deletion of Bmpr1a in Differentiated Osteoclasts Increases Osteoblastic Bone Formation, Increasing Volume of Remodeling Bone in Mice

    Mina Okamoto, Junko Murai, Yuuki Imai, Daisuke Ikegami, Nobuhiro Kamiya, Shigeaki Kato, Yuji Mishina, Hideki Yoshikawa, Noriyuki Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 26 No. 10 p. 2511-2522 2011/10 Research paper (scientific journal)

  69. Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state

    Hidetatsu Outani, Minoru Okada, Kunihiko Hiramatsu, Hideki Yoshikawa, Noriyuki Tsumaki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 411 No. 3 p. 607-612 2011/08 Research paper (scientific journal)

  70. ナトリウム利尿ペプチド受容体Bの機能獲得型変異はヒトおよびマウスにおいて成長促進と低骨密度をもたらす

    三浦 弘司, 難波 範行, 藤原 誠, 北岡 太一, 大幡 泰久, 平井 治彦, 大薗 恵一, 樋口 周久, 妻木 範行, 吉川 秀樹, 道上 敏美

    日本骨代謝学会学術集会プログラム抄録集 Vol. 29回 p. 180-180 2011/07 Research paper (conference, symposium, etc.)

    Publisher: (一社)日本骨代謝学会
  71. Expression of dominant negative TGF-beta receptors inhibits cartilage formation in conditional transgenic mice

    Kunihiko Hiramatsu, Takao Iwai, Hideki Yoshikawa, Noriyuki Tsumaki

    JOURNAL OF BONE AND MINERAL METABOLISM Vol. 29 No. 4 p. 493-500 2011/07 Research paper (scientific journal)

  72. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

    Daisuke Ikegami, Haruhiko Akiyama, Akira Suzuki, Takashi Nakamura, Toru Nakano, Hideki Yoshikawa, Noriyuki Tsumaki

    DEVELOPMENT Vol. 138 No. 8 p. 1507-1519 2011/04 Research paper (scientific journal)

  73. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

    Yukio Nakamura, Koji Yamamoto, Xinjun He, Bungo Otsuki, Youngwoo Kim, Hiroki Murao, Tsunemitsu Soeda, Noriyuki Tsumaki, Jian Min Deng, Zhaoping Zhang, Richard R. Behringer, Benoit de Crombrugghe, John H. Postlethwait, Matthew L. Warman, Takashi Nakamura, Haruhiko Akiyama

    NATURE COMMUNICATIONS Vol. 2 2011/03 Research paper (scientific journal)

  74. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage

    D. Ikegami, T. Iwai, S. Ryo, N. Gu, T. Sugiyama, I. Oh, H. Yoshikawa, N. Tsumaki

    OSTEOARTHRITIS AND CARTILAGE Vol. 19 No. 2 p. 233-241 2011/02 Research paper (scientific journal)

  75. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

    Kunihiko Hiramatsu, Satoru Sasagawa, Hidetatsu Outani, Kanako Nakagawa, Hideki Yoshikawa, Noriyuki Tsumaki

    JOURNAL OF CLINICAL INVESTIGATION Vol. 121 No. 2 p. 640-657 2011/02 Research paper (scientific journal)

  76. Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development

    Dai Suzuki, Atsushi Yamada, Takanori Amano, Rika Yasuhara, Ayako Kimura, Mizuho Sakahara, Noriyuki Tsumaki, Shu Takeda, Masaru Tamura, Masanori Nakamura, Naoyuki Wada, Tsutomu Nohno, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamijo

    DEVELOPMENTAL BIOLOGY Vol. 335 No. 2 p. 396-406 2009/11 Research paper (scientific journal)

  77. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene. (vol 275, pg 12712, 2000)

    Ying Liu, Haochuan Li, Kazuhiro Tanaka, Noriyuki Tsumaki, Yoshihiko Yamada

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 284 No. 17 p. 11748-11748 2009/04 Research paper (scientific journal)

  78. Generation of Rac1 conditional mutant mice by Cre/loxP system

    Dai Suzuki, Atsushi Yamada, Takanori Amano, Ayako Kimura, Rika Yasuhara, Mizuho Sakahara, Masaru Tamura, Noriyuki Tsumaki, Shu Takeda, Masanori Nakamura, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamijo

    TRANSMITTERS AND MODULATORS IN HEALTH AND DISEASE p. 175-+ 2009 Research paper (international conference proceedings)

  79. Bone biology: Development and regeneration mechanisms in physiological and pathological conditions

    Hideki Yoshikawa, Noriyuki Tsumaki, Akira Myoui

    Strategies in Regenerative Medicine: Integrating Biology with Materials Design p. 431-448 2009 Part of collection (book)

    Publisher: Springer New York
  80. Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2

    Junko Murai, Daisuke Ikegami, Mina Okamoto, Hideki Yoshikawa, Noriyuki Tsumaki

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 41 p. 27677-27687 2008/10 Research paper (scientific journal)

  81. Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways

    Takao Iwai, Junko Murai, Hideki Yoshikawa, Noriyuki Tsumaki

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 40 p. 27154-27164 2008/10 Research paper (scientific journal)

  82. Characteristics of fracture and related factors in patients with rheumatoid arthritis

    Akihide Nampei, Jun Hashimoto, Junichiro Koyanagi, Takeshi Ono, Hideo Hashimoto, Noriyuki Tsumaki, Tetsuya Tomita, Kazuomi Sugamoto, Norihiro Nishimoto, Takahiro Ochi, Hideki Yoshikawa

    MODERN RHEUMATOLOGY Vol. 18 No. 2 p. 170-176 2008/04 Research paper (scientific journal)

  83. Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic

    Iwai, Takao, Harada, Yoshifumi, Imura, Koichi, Iwabuchi, Sadahiro, Murai, Junko, Hiramatsu, Kunihiko, Myoui, Akira, Yoshikawa, Hideki, Tsumaki, Noriyuki

    JOURNAL OF BONE AND MINERAL METABOLISM Vol. 25 No. 6 p. 392-399 2007/11 Research paper (scientific journal)

  84. Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts

    Tadashi Sugiki, Taro Uyama, Masashi Toyoda, Hideo Morioka, Shoen Kume, Kenji Miyado, Kenji Matsumoto, Hirohisa Saito, Noriyuki Tsumaki, Yoriko Takahashi, Yoshiaki Toyama, Akihiro Umezawa

    JOURNAL OF CELLULAR BIOCHEMISTRY Vol. 100 No. 5 p. 1240-1254 2007/04 Research paper (scientific journal)

  85. Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification

    Makoto Hirao, Noriyuki Tamai, Noriyuki Tsumaki, Hideki Yoshikawa, Akira Myoui

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 281 No. 41 p. 31079-31092 2006/10 Research paper (scientific journal)

  86. Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development

    M Okamoto, J Murai, H Yoshikawa, N Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 21 No. 7 p. 1022-1033 2006/07 Research paper (scientific journal)

  87. [Bone morphogenetic proteins and their related molecules in the skeletal tissue].

    Tsumaki N, Yoshikawa H

    Clinical calcium Vol. 16 No. 5 p. 787-792 2006/05 Part of collection (book)

  88. [Roles of BMPs during endochondral bone formation].

    Iwai T, Tsumaki N, Yoshikawa H

    Nihon rinsho. Japanese journal of clinical medicine Vol. 63 Suppl 10 p. 431-434 2005/10 Research paper (conference, symposium, etc.)

  89. The role of bone morphogenetic proteins in endochondral bone formation

    N Tsumaki, H Yoshikawa

    CYTOKINE & GROWTH FACTOR REVIEWS Vol. 16 No. 3 p. 279-285 2005/06 Research paper (scientific journal)

  90. Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis

    N Tsumaki, M Kakiuchi, J Sasaki, T Ochi, H Yoshikawa

    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME Vol. 86A No. 11 p. 2399-2405 2004/11 Research paper (scientific journal)

  91. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow

    R Katayama, S Wakitani, N Tsumaki, Y Morita, Matsushita, I, R Gejo, T Kimura

    RHEUMATOLOGY Vol. 43 No. 8 p. 980-985 2004/08 Research paper (scientific journal)

  92. [Role of BMPs and Smads during endochondral bone formation].

    Tsumaki N, Horiki M, Murai J, Yoshikawa H

    Clinical calcium Vol. 14 No. 7 p. 52-57 2004/07 Part of collection (book)

  93. Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

    M Horiki, T Imamura, M Okamoto, M Hayashi, J Murai, A Myoui, T Ochi, K Miyazono, H Yoshikawa, N Tsumaki

    JOURNAL OF CELL BIOLOGY Vol. 165 No. 3 p. 433-445 2004/05 Research paper (scientific journal)

  94. 低リン血症性骨軟化症を併発したと考えられる関節リウマチの1例

    牧野 孝洋, 橋本 淳, 橋本 英雄, 妻木 範行, 冨田 哲也, 菅本 一臣, 吉川 秀樹

    中部日本整形外科災害外科学会雑誌 Vol. 47 No. 2 p. 375-376 2004/03 Research paper (conference, symposium, etc.)

    Publisher: 中部日本整形外科災害外科学会
  95. COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

    Y Matsui, HA Chansky, F Barahmand-Pour, A Zielinska-Kwiatkowska, N Tsumaki, A Myoui, H Yoshikawa, L Yang, DR Eyre

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 13 p. 11369-11375 2003/03 Research paper (scientific journal)

  96. Cartilage-specific overexpression of C-propeptide of type II collagen affected matrix mineralization in transgenic mice

    Y. Matsui, K. Nakata, E. Adachi, N. Tsumaki, T. Kimura, N. Yasui, E. Kataoka, Y. Fujita, H. Tsuboi, H. Yoshikawa

    Journal of Musculoskeletal Research Vol. 7 No. 3-4 p. 183-189 2003 Research paper (scientific journal)

  97. Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells

    Y Matsui, N Araki, H Tsuboi, N Tsumaki, K Nakata, H Kawabata, DR Eyre, H Yoshikawa

    ANTICANCER RESEARCH Vol. 22 No. 6C p. 4169-4172 2002/11 Research paper (scientific journal)

  98. Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis

    N Tsumaki, T Nakase, T Miyaji, M Kakiuchi, T Kimura, T Ochi, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 17 No. 5 p. 898-906 2002/05 Research paper (scientific journal)

  99. Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff

    Takanobu Nakase, Kazuomi Sugamoto, Takashi Miyamoto, Noriyuki Tsumaki, Frank P. Luyten, Hiroaki Inui, Akira Myoui, Tetsuya Tomita, Hideki Yoshikawa

    Clinical Orthopaedics and Related Research No. 399 p. 140-145 2002 Research paper (scientific journal)

    Publisher: Lippincott Williams and Wilkins
  100. Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum

    T Nakase, K Ariga, K Yonenobu, N Tsumaki, FP Luyten, Y Mukai, Sato, I, H Yoshikawa

    EUROPEAN SPINE JOURNAL Vol. 10 No. 4 p. 289-294 2001/08 Research paper (scientific journal)

  101. Alternative splicing of fibronectin transcripts in osteochondrogenic tumors

    Y Matsui, K Nakata, N Araki, K Ozono, Y Fujita, N Tsumaki, H Kawabata, N Yasui, K Sekiguchi, H Yoshikawa

    ANTICANCER RESEARCH Vol. 21 No. 2A p. 1103-1106 2001/03 Research paper (scientific journal)

  102. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene

    Y Liu, HC Li, K Tanaka, N Tsumaki, Y Yamada

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275 No. 17 p. 12712-12718 2000/04 Research paper (scientific journal)

  103. Enhancer analysis of the alpha 1(II) and alpha 2(XI) collagen genes in transfected chondrocytes and transgenic mice.

    N. Tsumaki, Y. Liu, Y. Yamada, P. Krebsbach

    Methods in molecular biology (Clifton, N.J.) Vol. 139 p. 187-195 2000 Part of collection (book)

  104. A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia

    Y Matsui, N Yasui, H Kawabata, K Ozono, K Nakata, T Mizushima, N Tsumaki, E Kataoka, Y Fujita, T Ochi

    JOURNAL OF HUMAN GENETICS Vol. 45 No. 2 p. 105-108 2000 Research paper (scientific journal)

  105. Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation

    N Tsumaki, K Tanaka, E Arikawa-Hirasawa, T Nakase, T Kimura, JT Thomas, T Ochi, FP Luyten, Y Yamada

    JOURNAL OF CELL BIOLOGY Vol. 144 No. 1 p. 161-173 1999/01 Research paper (scientific journal)

  106. Genotype phenotype correlation in achondroplasia and hypochondroplasia

    Y Matsui, N Yasui, T Kimura, N Tsumaki, H Kawabata, T Ochi

    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME Vol. 80B No. 6 p. 1052-1056 1998/11 Research paper (scientific journal)

  107. Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha 2(XI) collagen promoter

    N Tsumaki, T Kimura, K Tanaka, JH Kimura, T Ochi, Y Yamada

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273 No. 36 p. 22861-22864 1998/09 Research paper (scientific journal)

  108. Differential in situ expression of alpha 2(XI) collagen mRNA isoforms in the developing mouse

    M Sugimoto, T Kimura, N Tsumaki, Y Matsui, K Nakata, H Kawahata, N Yasui, Y Kitamura, S Nomura, T Ochi

    CELL AND TISSUE RESEARCH Vol. 292 No. 2 p. 325-332 1998/05 Research paper (scientific journal)

  109. Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors

    Y Matsui, T Kimura, N Tsumaki, K Nakata, N Yasui, N Araki, N Hashimoto, A Uchida, T Ochi

    CANCER LETTERS Vol. 124 No. 2 p. 143-148 1998/02 Research paper (scientific journal)

  110. A recurrent 1992delCT mutation of the type X collagen gene in a Japanese patient with Schmid metaphyseal chondrodysplasia

    Y Matsui, T Kimura, N Tsumaki, N Yasui, T Ochi

    JAPANESE JOURNAL OF HUMAN GENETICS Vol. 41 No. 3 p. 339-342 1996/09 Research paper (scientific journal)

  111. Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage

    N Tsumaki, T Kimura, Y Matsui, K Nakata, T Ochi

    JOURNAL OF CELL BIOLOGY Vol. 134 No. 6 p. 1573-1582 1996/09 Research paper (scientific journal)

  112. Cervical spondylotic radiculopathy involving two adjacent nerve roots - Anterior decompression through a single level intervertebral approach

    M Iwasaki, K Okada, N Tsumaki, H Obata, N Shirasaki, S Oka

    INTERNATIONAL ORTHOPAEDICS Vol. 20 No. 3 p. 137-141 1996/06 Research paper (scientific journal)

  113. Progressive degeneration of articular cartilage and intervertebral discs - An experimental study in transgenic mice bearing a type IX collagen mutation

    T Kimura, K Nakata, N Tsumaki, S Miyamoto, Y Matsui, S Ebara, T Ochi

    INTERNATIONAL ORTHOPAEDICS Vol. 20 No. 3 p. 177-181 1996/06 Research paper (scientific journal)

  114. Separable regulatory elements from pro-alpha 2(XI) collagen gene drive distinct patterns of cartilage-specific expression in transgenic mice

    N Tsumaki, M Sugimoto, K Nakata, Y Matsui, T Ochi, T Kimura

    MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE Vol. 785 p. 340-342 1996 Research paper (international conference proceedings)

  115. DIFFERENTIAL EXPRESSION OF AN ACIDIC DOMAIN IN THE AMINO-TERMINAL PROPEPTIDE OF MOUSE PRO-ALPHA-2(XI) COLLAGEN BY COMPLEX ALTERNATIVE SPLICING

    N TSUMAKI, T KIMURA

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 270 No. 5 p. 2372-2378 1995/02

  116. ALTERED CHONDROCYTE GENE-EXPRESSION IN ARTICULAR-CARTILAGE MATRIX COMPONENTS AND SUSCEPTIBILITY TO CARTILAGE DESTRUCTION

    T KIMURA, K NAKATA, N TSUMAKI, K ONO

    CELL MECHANICS AND CELLULAR ENGINEERING p. 445-456 1994 Part of collection (book)

Misc. 132

  1. Regeneration of articular cartilage: Basic research and application of allogeneic iPS cell-derived cartilage transplantation

    阿部健吾, 妻木範行

    日本整形外科学会雑誌 Vol. 98 No. 1 2024

  2. ヒトiPS細胞から軟骨を分化誘導する方法の開発

    妻木 範行

    北隆館「Precision Medicine」変形性関節症:病態研究と治療の最前線 Vol. 6 No. 11 p. 1-4 2023/10/25 Article, review, commentary, editorial, etc. (scientific journal)

  3. ヒトの再生をめぐる諸問題 軟骨の再生

    妻木範行, 妻木範行

    Hormone Frontier in Gynecology Vol. 30 No. 1 2023

  4. 関節軟骨損傷における再生治療-iPS細胞を用いた新しい治療法開発

    妻木範行, 妻木範行, 妻木範行

    SRL宝函 Vol. 44 No. 2 2023

  5. Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus

    釜谷崇志, 萩澤宏樹, 妻木範行, 海渡貴司

    整形・災害外科 Vol. 66 No. 10 2023

  6. Regulation of chondrocyte differentiation and regenerative therapy for articular cartilage damage

    妻木範行, 妻木範行, 妻木範行

    生体の科学 Vol. 74 No. 6 2023

  7. Salt inducible kinase 3 (SIK3) mediate shear stress-induced up-regulation of lubricin at the articular cartilage surface

    武井義明, 武井義明, 小林与人, 堀家なな緒, 森岡美帆, 高才東, 釜谷崇志, 山下晃弘, 竹森洋, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 33rd 2020

  8. 椎間板変性に対する選択的c-Fos/AP-1阻害薬の治療効果

    牧野紘士, 関庄二, 箭原康人, 塩沢俊一, 妻木範行, 木村友厚

    日本軟骨代謝学会プログラム・抄録集 Vol. 31st 2018

  9. Application of iPS cell technologies to regenerate articular cartilage damage and model skeletal dysplasia

    Tsumaki Noriyuki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society Vol. WCP2018 2018

    Publisher: Japanese Pharmacological Society
  10. A Therapeutic Target of Intervertebral Disc Disease and Regeneration Based on Suppressing Intervertebral Disc Degeneration

    Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research Vol. 8 No. 6 p. 1127-1131 2017/06

    Publisher: 日本脊椎脊髄病学会
  11. iPS細胞および分子標的によるOA治療戦略 (特集 OAの最新治療 : 関節再生を目指して)

    妻木 範行

    分子リウマチ治療 Vol. 10 No. 2 p. 61-64 2017/05

    Publisher: 先端医学社
  12. ROLE OF SIK3 IN PATHOLOGY OF OSTEOARTHRITIS IN MICE

    N. Tsumaki

    OSTEOARTHRITIS AND CARTILAGE Vol. 25 p. S5-S6 2017/04 Research paper, summary (international conference)

  13. ヒトiPS細胞由来軟骨移植の安全性評価-ラット膝関節軟骨欠損モデルを用いて-

    小林与人, 小林与人, 山下晃弘, 森岡美帆, 釜谷崇志, 高才東, KNUT Woltjen, 松田秀一, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 30th 2017

  14. 疾患特異的ヒトiPS細胞を用いた内軟骨性骨化モデル

    木村武司, 木村武司, 安田紀恵, 窪田拓生, 三善陽子, 山下晃弘, 妻木範行, 大薗恵一

    日本小児内分泌学会学術集会プログラム・抄録集 Vol. 51st 2017

  15. Application of iPS cell technologies to regeneration of cartilage damage

    Osaka Academy of Oral Implantology Vol. 31 p. 17-19 2017

    Publisher: 大阪口腔インプラント研究会
  16. ESTABLISHMENT OF A HUMAN GROWTH PLATE MODEL WITH IPS CELL-DERIVED CARTILAGE

    Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki

    HORMONE RESEARCH IN PAEDIATRICS Vol. 88 p. 9-10 2017 Research paper, summary (international conference)

  17. Use of Cell iPS Cell Technologies in Cartilage Regeneration and Disease Modelling of Skeletal Dysplasia

    Vol. 71 No. 8 p. 1726-1731 2016/08

    Publisher: 最新医学社
  18. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (vol 7, 10959, 2016)

    Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki

    NATURE COMMUNICATIONS Vol. 7 2016/06 Other

  19. SIK3経路阻害剤は変形性関節症の進行を抑制する

    箭原康人, 箭原康人, 竹森洋, 木村友厚, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 29th 2016

  20. SIK3をターゲットとした変形性関節症の治療

    箭原康人, 竹森洋, 岡田稔, 高才東, 山下晃弘, 小林与人, 藤田香里, 伊東裕美, 中村正裕, 渕野裕之, 川原信夫, 福井尚志, 渡辺亮, 木村友厚, 妻木範行

    日本骨代謝学会学術集会プログラム抄録集 Vol. 34th 2016

  21. ヒトiPS細胞由来軟骨細胞の免疫原性の解析

    木村武司, 木村武司, 森岡美穂, 山下晃弘, 大薗恵一, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 29th 2016

  22. P2-52-6 ダイレクトリプログラミング技術を用いた2型コラーゲン異常症の疾患モデル系の確立(Group52 胎児・新生児の病理,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

    澤井 英明, 室月 淳, 妻木 範行

    日本産科婦人科學會雜誌 Vol. 68 No. 2 p. 771-771 2016

    Publisher: 日本産科婦人科学会
  23. スタチンによるFGFR3軟骨形成異常症の病態回復

    山下晃弘, 森岡美帆, 岸宏美, 木村武司, 箭原康人, 岡田稔, 藤田香里, 澤井英明, 池川志郎, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 29th 2016

  24. Application of cell reprogramming technologies to research for cartilage diseases

    Vol. 89 No. 12 p. 1017-1024 2015/12

    Publisher: 日本整形外科学会
  25. Chondrogenic differentiation of human iPS cells and production of hyaline cartilaginous tissue

    Vol. 14 No. 4 p. 378-382 2015/11

    Publisher: メディカルレビュー社
  26. Drug screening using iPS cell model and direct reprogramming technologies

    Vol. 58 No. 3 p. 325-330 2015/03

    Publisher: 金原出版
  27. 生後軟骨の恒常性維持におけるSIK3の役割

    箭原康人, 箭原康人, 木村友厚, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 28th 2015

  28. ヒトiPS細胞から硝子軟骨様組織への分化誘導法の確立

    山下晃弘, 森岡美帆, 箭原康人, 岡田稔, 小田直純, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 28th 2015

  29. ヒトiPS細胞を用いた移植可能な軟骨様組織の作成

    山下晃弘, 森岡美帆, 箭原康人, 岡田稔, 妻木範行

    再生医療 Vol. 14 2015

  30. 疾患特異的iPS細胞モデルを用いた軟骨形成に対するIGF1の効果の検討

    木村武司, 木村武司, 森岡美穂, 山下晃弘, 妻木範行, 大薗恵一

    日本整形外科学会雑誌 Vol. 89 No. 9 2015

  31. The effect of IGF-1 on chondrogcnic differentiation model with disease-specific human induced pluripotent stem cells

    Vol. 63 No. 1 p. 3-5 2015/01

    Publisher: 医学の世界社
  32. Cartilage regeneration, modeling of skeletal dysplasia and cell reprogramming technologies

    Vol. 251 No. 4 p. 321-327 2014/10/25

    Publisher: 医歯薬出版
  33. Direct reprogramming toward chondrocytes

    Vol. 46 No. 5 p. 216-219 2014/05

    Publisher: ニューサイエンス社
  34. DERIVATION OF TRANSPLANTABLE CARTILAGE FROM HUMAN INDUCED PLURIPOTENT STEM CELLS

    A. Yamashita, M. Morioka, Y. Yahara, M. Okada, N. Tsumaki

    OSTEOARTHRITIS AND CARTILAGE Vol. 22 p. S30-S30 2014/04 Research paper, summary (international conference)

  35. Cartilage regeneration by chondrogenic cells generated by cell reprogramming technologies

    Vol. 56 No. 5 p. 573-584 2013/04

    Publisher: 金原出版
  36. Regulation of chondrocyte differentiation and cartilage regeneration

    Vol. 45 No. 1 p. 9-13 2013/01

    Publisher: ニューサイエンス社
  37. 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築

    室月淳, 澤井英明, 山田崇弘, 堤誠司, 佐藤秀平, 林聡, 篠塚憲男, 高橋雄一郎, 佐世正勝, 鬼頭浩史, 沼部博直, 宮崎治, 緒方勤, 池川志郎, 妻木範行, 芳賀信彦, 西村玄

    致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書 2013

  38. 細胞リプログラミング技術を用いたII型コラーゲン病疾患モデルの解析

    岡田稔, 池川志郎, 今泉和則, 澤井英明, 室月淳, 大橋博文, 妻木範行

    日本軟骨代謝学会プログラム・抄録集 Vol. 26th 2013

  39. 致死性骨異形成症の診断と予後に関する研究 致死性骨異形成症のiPS細胞作成に関する研究

    妻木範行, 澤井英明, 室月淳, 池川志郎

    致死性骨異形成症の診断と予後に関する研究 平成24年度 総括・分担研究報告書 2013

  40. ナトリウム利尿ペプチド受容体B(NPR-B)変異に起因する軟骨の表現型の解析

    三浦 弘司, 難波 範行, 藤原 誠, 大幡 泰久, 北岡 太一, 窪田 拓生, 大薗 恵一, 樋口 周久, 吉川 秀樹, 妻木 範行, 道上 敏美

    日本内分泌学会雑誌 Vol. 88 No. 1 p. 203-203 2012/04

    Publisher: (一社)日本内分泌学会
  41. 致死性骨異形成症の診断と予後に関する研究 症例の収集と診断の支援システム構築

    室月淳, 澤井英明, 山田崇弘, 堤誠司, 佐藤秀平, 林聡, 篠塚憲男, 高橋雄一郎, 佐世正勝, 鬼頭浩史, 沼部博直, 宮崎治, 緒方勤, 池川志郎, 妻木範行, 西村玄

    致死性骨異形成症の診断と予後に関する研究 平成23年度 総括・分担研究報告書 2012

  42. Directed induction of chondrogenic cells from mouse dermal fibroblast culture

    Noriyuki Tsumaki

    ARTHRITIS RESEARCH & THERAPY Vol. 14 2012 Research paper, summary (international conference)

  43. Direct induction of chondrogenic cells from mouse dermal fibroblast culture

    Vol. 239 No. 14 p. 1332-1337 2011/12/31

    Publisher: 医歯薬出版
  44. A GAIN-OF-FUNCTION TYPE MUTATION OF THE NATRIURETIC PEPTIDE RECEPTOR B CAUSES ACCELERATION OF SKELETAL GROWTH AND OSTEOPOROTIC CHANGE IN HUMANS AND MICE

    K. Miura, N. Namba, M. Fujiwara, T. Kitaoka, Y. Ohata, H. Hirai, C. Higuchi, N. Tsumaki, H. Yoshikawa, T. Michigami, K. Ozono

    OSTEOPOROSIS INTERNATIONAL Vol. 22 p. S536-S536 2011/09 Research paper, summary (international conference)

  45. CILP(cartilage intermediate layer protein)トランスジェニックマウスの椎間板変性促進効果

    関庄二, 妻木範行, 松井好人, 川口善治, 阿部由美子, 鈴木賀代, 岩井昭子, 佐野明美, 尾矢剛志, 池川志郎, 木村友厚

    日本整形外科学会雑誌 Vol. 84 No. 8 2010

  46. 関節リウマチ患者骨髄中の原因病巣を探り続けて

    越智 隆弘, 吉川 秀樹, 橋本 淳, 中田 研, 妻木 範行, 冨田 哲也, 島岡 康則, 蛯名 耕介, 武 靖浩, 鈴木 隆二, 澤井 高志

    日本整形外科学会雑誌 Vol. 83 No. 8 p. S1004-S1004 2009/08

    Publisher: (公社)日本整形外科学会
  47. Essential role of small GTPase Rac1 during limb development

    D. Suzuki, A. Yamada, T. Amano, A. Kimura, R. Yasuhara, M. Sakahara, M. Tamura, N. Tsumaki, S. Takeda, M. Nakamura, T. Shiroishi, A. Aiba, R. Kamijo

    BONE Vol. 44 p. S50-S51 2009/05 Research paper, summary (international conference)

  48. Rac1はプログラム細胞死関連遺伝子の発現調節を介して肢芽指間域におけるアポトーシスを制御する

    鈴木 大, 山田 篤, 天野 孝紀, 木村 文子, 安原 理佳, 妻木 範行, 竹田 秀, 田村 勝, 中村 雅典, 城石 俊彦, 饗場 篤, 上條 竜太郎

    口腔組織培養学会誌 Vol. 18 No. 1 p. 5-6 2009/02

    Publisher: 日本口腔組織培養学会
  49. 低分子量Gタンパク質Rac1は四肢形成に必須である

    鈴木 大, 山田 篤, 木村 文子, 安原 理佳, 妻木 範行, 竹田 秀, 松本 貴志, 馬場 一美, 中村 雅典, 饗場 篤, 上條 竜太郎

    日本骨代謝学会学術集会プログラム抄録集 Vol. 26回 p. 138-138 2008/10

    Publisher: (一社)日本骨代謝学会
  50. 低分子量Gタンパク質Rac1は四肢形成に必須である

    鈴木 大, 山田 篤, 安原 理佳, 木村 文子, 妻木 範行, 竹田 秀, 中村 雅典, 饗場 篤, 上條 竜太郎

    補体シンポジウム講演集 Vol. 45 p. 181-181 2008/07

    Publisher: (一社)日本補体学会
  51. Inhibitory Smad6 and Smad7 differently regulate cartilage formation

    T. Iwai, J. Murai, H. Yoshikawa, N. Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 p. S100-S100 2007/09 Research paper, summary (international conference)

  52. Analysis of the function of the CTCF-binding site between the Rxrb and the Col11a2 genes

    J. Murai, M. Okamoto, H. Yoshikawa, N. Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 p. S260-S260 2007/09 Research paper, summary (international conference)

  53. 最新原著レビュー 低出力超音波パルス照射は片側仮骨延長法を用いた高位脛骨骨切り術における延長仮骨治癒を促進する

    妻木 範行

    整形外科 Vol. 57 No. 11 p. 1531-1535 2006/10

    Publisher: 南江堂
  54. Regulation of the col11a2 expression through the histone modification.

    J. Murai, H. Yoshikawa, N. Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 21 p. S340-S340 2006/09 Research paper, summary (international conference)

  55. Role of Smad7 during endochondral bone formation.

    T. Iwai, J. Murai, H. Yoshikawa, N. Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 21 p. S33-S33 2006/09 Research paper, summary (international conference)

  56. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha 2(XI) collagen gene (vol 275, pg 12712, 2000)

    Y Liu, HC Li, K Tanaka, N Tsumaki, Y Yamada

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 281 No. 27 p. 18908-18908 2006/07 Other

  57. 連通気孔を有する3D-CAD人工骨を用いた高位脛骨骨切術の短期成績

    妻木 範行, 海渡 貴司, 岩井 貴男, 村瀬 剛, 名井 陽, 吉川 秀樹

    日本整形外科学会雑誌 Vol. 80 No. 3 p. S103-S103 2006/03

    Publisher: (公社)日本整形外科学会
  58. CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよびハイドロキシアパタイトインプラントの術前モデリング

    海渡 貴司, 名井 陽, 村瀬 剛, 妻木 範行, 冨田 哲也, 吉川 秀樹

    Orthopaedic Ceramic Implants Vol. 23〜24 p. 119-124 2005/12

    Publisher: 整形外科バイオマテリアル研究会
  59. CTデータに基づく3D-CADモデルを利用したハイドロキシアパタイトインプラントの術前モデリング

    村瀬 剛, 海渡 貴司, 名井 陽, 玉井 宣行, 妻木 範行, 冨田 哲也, 森友 寿夫, 岡 久仁洋, 吉川 秀樹

    日本バイオマテリアル学会大会予稿集 Vol. 27回 p. 288-288 2005/11

    Publisher: 日本バイオマテリアル学会
  60. BMP signaling in bone stimulates osteoclastic bone resorption and remodeling during endochondral bone formation and fracture repair.

    M Okamoto, J Murai, H Yoshikawa, N Tsumaki

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 20 No. 9 p. S322-S322 2005/09 Research paper, summary (international conference)

  61. Hypoxia promotes cartilage matrix synthesis via p38 MAPKinase and suppresses terminal differentiation via HDAC4

    M Hirao, N Tamai, A Myoui, N Tsumaki, N Araki, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 20 No. 9 p. S7-S7 2005/09 Research paper, summary (international conference)

  62. Low-intensity pulsed ultrasound and new bone formation within interconnected porous calcium hydroxyapatite ceramics.

    T Iwai, N Tsumaki, J Murai, A Myoui, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 20 No. 9 p. S210-S210 2005/09 Research paper, summary (international conference)

  63. Fracture incidence and risk factors in patients with rheumatoid arthritis

    A Nampei, J Hashimoto, J Koyanagi, H Hashimoto, N Tsumaki, T Tomita, K Sugamoto, N Nishimoto, H Yoshikawa, T Ochi

    ANNALS OF THE RHEUMATIC DISEASES Vol. 64 p. 348-348 2005/07 Research paper, summary (international conference)

  64. Role of BMP signals in endochondral ossification and fracture repair; Activation of osteoclastic resorption and remodeling of bone

    M Okamoto, J Murai, H Yoshikawa, N Tsumaki

    BONE Vol. 36 p. S118-S118 2005/06 Research paper, summary (international conference)

  65. Overexpression of BMP4 in bone increased osteoclast number and caused osteopenia

    J Murai, M Okamoto, H Yoshikawa, N Tsumaki

    BONE Vol. 36 p. S119-S119 2005/06 Research paper, summary (international conference)

  66. Bone morphogenetic protein signaling in chondrocyte proliferation and hypertrophy during endochondral bone formation

    T Iwai, M Horiki, J Murai, H Yoshikawa, N Tsumaki

    BONE Vol. 36 p. S174-S175 2005/06 Research paper, summary (international conference)

  67. Effect of low-intensity pulsed ultrasound on maturation of callus in opening-wedge high tibial osteotomy by hemicallotasis

    TSUMAKI Noriyuki, KAKIUCHI Masaaki, SASAKI Jiro, OCHI Takahiro, YOSHIKAWA Hideki

    Vol. 16 p. 155-156 2005/05/20

  68. CTデータに基づく3D-CADを利用したハイドロキシアパタイトインプラントの術前モデリング

    村瀬 剛, 海渡 貴司, 名井 陽, 玉井 宣行, 妻木 範行, 冨田 哲也, 森友 寿夫, 岡 久仁洋, 上田 孝文, 菅本 一臣, 吉川 秀樹

    日本整形外科学会雑誌 Vol. 79 No. 3 p. S205-S205 2005/03

    Publisher: (公社)日本整形外科学会
  69. CTデータに基づく3D-CADモデルを利用した手術シミュレーションおよび術前ハイドロキシアパタイトインプラントの術前モデリング

    海渡 貴司, 名井 陽, 村瀬 剛, 妻木 範行, 冨田 哲也, 吉川 秀樹

    整形外科セラミック・インプラント研究会プログラム・抄録集 Vol. 24回 p. 26-26 2004/12

    Publisher: 整形外科バイオマテリアル研究会
  70. Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis

    N Tsumaki, M Kakiuchi, J Sasaki, T Ochi, H Yoshikawa

    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME Vol. 86A No. 11 p. 2399-2405 2004/11

  71. Hypoxia promotes chondrocytic differentiation in vitro and cartilaginous matrix synthesis in organ culture via p38 kinase pathway

    M Hirao, N Tamai, N Tsumaki, A Myoui, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 19 p. S61-S61 2004/10 Research paper, summary (international conference)

  72. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow

    R Katayama, S Wakitani, N Tsumaki, Y Morita, Matsushita, I, R Gejo, T Kimura

    RHEUMATOLOGY Vol. 43 No. 8 p. 980-985 2004/08

  73. Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

    M Horiki, T Imamura, M Okamoto, M Hayashi, J Murai, A Myoui, T Ochi, K Miyazono, H Yoshikawa, N Tsumaki

    JOURNAL OF CELL BIOLOGY Vol. 165 No. 3 p. 433-445 2004/05

  74. Overexpression of BMP4 in osteoblasts causes osteopenia in transgenic mice

    J Murai, N Tsumaki, M Horiki, Y Hashimoto, K Kuriyama, H Yoshikawa

    BONE Vol. 34 p. S9-S10 2004 Research paper, summary (international conference)

  75. Hypoxia promotes chondrocytic differentiation of C3H10T1/2 cells induced by bone morphogenetic protein-2

    M Hirao, N Tamai, N Tsumaki, A Myoui, H Yoshikawa

    BONE Vol. 34 p. S35-S36 2004 Research paper, summary (international conference)

  76. Overexpression of BMP4 in osteoblasts causes severe osteopenia in transgenic mice.

    N Tsumaki, M Horiki, Y Hashimoto, K Kuriyama, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 18 p. S50-S51 2003/09 Research paper, summary (international conference)

  77. Overexpression of Smad6 in chondrocytes distinctively disturbs terminal differentiation of chondrocytes and causes osteopenia in transgenic mice.

    M Horiki, N Tsumaki, A Myoui, T Imamura, H Yoshikawa

    JOURNAL OF BONE AND MINERAL RESEARCH Vol. 18 p. S60-S60 2003/09 Research paper, summary (international conference)

  78. Role of Smad6 during cartilage formation

    M Horiki, N Tsumaki, A Myoui, T Miyaji, T Imamura, H Yoshikawa

    BONE Vol. 32 No. 5 p. S110-S110 2003/05 Research paper, summary (international conference)

  79. 軟骨形成における11型コラーゲンα2鎖遺伝子の役割と転写制御 (運動器科学の創生)

    妻木 範行

    医学のあゆみ Vol. 205 No. 3 p. 184-186 2003/04/19

    Publisher: 医歯薬出版
  80. 膝内反変形を伴う膝関節内側軟骨障害に対し自家骨軟骨移植術と高位脛骨骨切り術同時施行例の術後成績

    中田 研, 史野 根生, 桑野 吉浩, 福岡 慎一, 田川 泰弘, 妻木 範行, 小畠 秀人, 多田 浩一

    日本整形外科学会雑誌 Vol. 77 No. 3 p. S226-S226 2003/03

    Publisher: (公社)日本整形外科学会
  81. COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

    Y Matsui, HA Chansky, F Barahmand-Pour, A Zielinska-Kwiatkowska, N Tsumaki, A Myoui, H Yoshikawa, L Yang, DR Eyre

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278 No. 13 p. 11369-11375 2003/03

  82. Role of bone morphogenetic protein signals during skeletal development

    N Tsumaki, M Horiki, T Kimura, H Yoshikawa

    ARTHRITIS RESEARCH & THERAPY Vol. 5 p. S8-S8 2003 Research paper, summary (international conference)

  83. Repair of rabbit articular cartilage defect using CDMP1-transfected autologous mesenchymal stem cell derived from bone marrow.

    R Katayama, S Wakitani, N Tsumaki, H Matsuno, L Frank, K Yudoh, T Kimura

    ARTHRITIS AND RHEUMATISM Vol. 46 No. 9 p. S585-S585 2002/09 Research paper, summary (international conference)

  84. 間葉系細胞と遺伝子導入による修復

    片山 理恵, 脇谷 滋之, 妻木 範行, 松野 博明, 木村 友厚

    日本整形外科学会雑誌 Vol. 76 No. 8 p. S944-S944 2002/08

    Publisher: (公社)日本整形外科学会
  85. A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene (Retracted Article)

    K Tanaka, N Tsumaki, CA Kozak, Y Matsumoto, F Nakatani, Y Iwamoto, Y Yamada

    MOLECULAR AND CELLULAR BIOLOGY Vol. 22 No. 12 p. 4256-4267 2002/06

  86. Matsui, Y., Araki, N., Tsuboi, H., Tsumaki, N., Nakata, K., Kawabata, H., Eyre, D. R., and Yoshikawa, H.: Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells.

    Anticancer Res Vol. 22(6C): 4169-4172 2002

  87. Nakase, T., Sugamoto, K., Miyamoto, T., Tsumaki, N., Luyten, F. P., Inui, H., Myoui, A., Tomita, T., and Yoshikawa, H.: Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff.

    Clin Orthop Vol. (399): 140-145 2002

  88. 骨髄由来間葉系幹細胞に対するCDMP1遺伝子導入と軟骨分化誘導の促進

    片山 理恵, 脇谷 滋之, 妻木 範行, 松野 博明, 遊道 和雄, 木村 友厚

    日本整形外科学会雑誌 Vol. 75 No. 8 p. S850-S850 2001/08

    Publisher: (公社)日本整形外科学会
  89. BMP signals are required for cartilage formation.

    Tsumaki N., Nakase T., Miyaji E. T., Kakiuchi M., Ochi T., Yamada Yoshihiko, Kimura T., Yoshikawa H.

    Connective tissue Vol. 33 No. 2 p. 169-169 2001/06

    Publisher: The Japanese Society for Connective Tissue
  90. Flagエピトープ標識II型コラーゲンCプロペプチド過剰発現マウスにおける外来遺伝子発現の免疫組織学的検索(Demonstration of type II collagen C-propeptide tagged with Flag epitope (DYKDDDDK) in cartilage of transgenic mice)

    松井 好人, 中田 研, 妻木 範行, 片岡 英一郎, 木村 友厚, Adachi Eijiro, Matsui Yoshito, Nakata Ken, Tsumaki Noriyuki, Kataoka Eiichiro, Kimura Tomoatsu

    解剖学雑誌 Vol. 76 No. 1 p. 68-68 2001/02

    Publisher: (一社)日本解剖学会
  91. Matsui, Y., Nakata, K., Araki, N., Ozono, K., Fujita, Y., Tsumaki, N., Kawabata, H., Yasui, N., Sekiguchi, K., and Yoshikawa, H.: Alternative splicing of fibronectin transcripts in osteochondrogenic tumors.

    Anticancer Res Vol. 21(2A): 1103-1106 2001

  92. Role of BMP4 during Chondrocyte Differentiation

    TSUMAKI N.

    Vol. 74 No. 8 2000/08/25

  93. 軟骨性腫瘍におけるフィブロネクチンmRNAの選択的スプライシング

    松井 好人, 中田 研, 安井 夏生, 荒木 信人, 大薗 恵一, 妻木 範行, 藤田 良, 栗山 幸治, 川端 秀彦, 越智 隆弘

    日本整形外科学会雑誌 Vol. 74 No. 8 p. S1348-S1348 2000/08/25

    Publisher: (公社)日本整形外科学会
  94. Involvement of Ptc/Gli-BMP signaling in the Periosteum in the Early Phase of Fracture Repair

    NAKASE T.

    Vol. 74 No. 8 2000/08/25

  95. 軟骨変性と遺伝子の発現 -軟骨細胞signaling pathway における意味づけ-

    妻木 範行, 垣内 雅明, 吉川 秀樹, 木村 友厚, 越智 隆弘

    リウマチ Vol. 40 No. 2 p. 263-263 2000/04/26

  96. A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia

    Y. Matsui, N. Yasui, H. Kawabata, K. Ozono, K. Nakata, T. Mizushima, N. Tsumaki, E. Kataoka, Y. Fujita, T. Ochi

    Journal of Human Genetics Vol. 45 No. 2 p. 105-108 2000/03

    Publisher: Springer Science and Business Media LLC
  97. Transcriptional Regulation of Cartilage-specific Collagen Gene, Col11a2

    TSUMAKI N., YAMADA Yoshihiko

    Vol. 74 No. 2 2000/02/25

  98. Targeted gene expression in human articular cartilage by direct in vivo gene transfer into SCID-HuRAg mouse.

    R Katayama, T Tomita, N Tsumaki, T Ochi, H Matsuno, Y Morita, K Yudoh, F Nakazawa, T Kimura

    ARTHRITIS AND RHEUMATISM Vol. 42 No. 9 p. S107-S107 1999/09 Research paper, summary (international conference)

  99. 軟骨の形成・分化に対するBMPシグナルの作用

    妻木 範行, 中瀬 尚長, 冨田 哲也, 吉川 秀樹, 垣内 雅明, 木村 友厚, YAMADA Y., 越智 隆弘

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association Vol. 73 No. 8 1999/08/25

  100. 軟骨組織特異的遺伝子発現システムを用いた関節軟骨への in vivo 遺伝子導入

    片山 理恵, 冨田 哲也, 妻木 範行, 越智 隆弘, 松野 博明, 遊道 和雄, 中沢 不二雄, 木村 友厚

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association Vol. 73 No. 8 1999/08/25

  101. II型コラーゲン遺伝子の軟骨特異的エンハンサーに結合するタンパク質(CSEBP-2)の遺伝子発現とゲノム構造の解析

    片岡 英一郎, 丹羽 仁史, 中田 研, 松井 好人, 木村 友厚, 妻木 範行, 山田 吉彦, 安井 夏生, 宮崎 純一, 越智 隆弘

    日本整形外科学会雑誌 Vol. 73 No. 8 p. S1609-S1609 1999/08/25

    Publisher: (公社)日本整形外科学会
  102. II型コラーゲンCプロペプチドが軟骨分化と軟骨基質の石灰化に及ぼす作用 過剰発現トランスジェニックマウスを用いた解析

    松井 好人, 中田 研, 安達 栄治郎, 木村 友厚, 妻木 範行, 安井 夏生, 片岡 英一郎, 藤田 良, 越智 隆弘

    日本整形外科学会雑誌 Vol. 73 No. 8 p. S1562-S1562 1999/08

    Publisher: (公社)日本整形外科学会
  103. 【変形性関節症の基礎と臨床】 OAの動物モデル

    木村 友厚, 松野 博明, 遊道 和雄, 中田 研, 妻木 範行

    リウマチ科 Vol. 22 No. 1 p. 4-9 1999/07

    Publisher: (有)科学評論社
  104. ヒト骨軟骨形成性疾患における CDMP (Cartilage-derived morphogenetic protein)-1 遺伝子の発現様式について

    中瀬 尚長, 金子 元春, 有賀 健太, 妻木 範行, 冨田 哲也, 菅本 一臣, 宮本 紳平, 名井 陽, 吉川 秀樹, 米延 策雄, 越智 隆弘

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism Vol. 17 No. 2 p. 296-296 1999/06/26

  105. Identification of the regulatory sequences responsible for cartilage-specific expression of the Col11a2 gene and their application : a role of BMP signals in the skeletal development

    Tsumaki N., Kimura T., Yamada Y., Ochi T.

    Connective tissue Vol. 31 No. 2 p. 87-87 1999/06

    Publisher: The Japanese Society for Connective Tissue
  106. Identification of a transcription factor that regulates tissue-specific expression of α2(XI)collagen gene.

    Tanaka K., Tsumaki N., Yamada Y., Iwamoto Y.

    Connective tissue Vol. 31 No. 2 p. 95-95 1999/06

    Publisher: The Japanese Society for Connective Tissue
  107. Cartilage degeneration and genes

    KIMURA T., MATSUNO H., YUDOH K., TSUMAKI N., TOMITA T., OCHI T.

    Vol. 39 No. 2 p. 230-230 1999/04/30

  108. 軟骨特異的転写制御メカニズムの解明とその応用

    妻木 範行, 木村 友厚, YAMADA Yoshihiko, 越智 隆弘

    リウマチ Vol. 39 No. 2 p. 269-269 1999/04/30

  109. Immunohistochemical detection of the foreign gene expression in transgenic mice overxpressing the FLAG epitope tagged chondrocalcin in cartilage

    Matsui Y, Nakata K, Adachi E, Kimura T, Tsumaki N, Katsumata O, Yasui N, Kataoka E, Fujita Y, Ochi T

    Connective tissue Vol. 31 No. 2 p. 126-126 1999

    Publisher: 日本結合組織学会
  110. Inhibition of proliferation of synovial cells from patients with rheumatoid arthritis by overexpression of p21 gene through induction of apoptosis.

    T Tomita, E Takeuchi, N Tomita, R Morishita, M Kaneko, H Matsushita, H Takano, N Tsumaki, Y Kaneda, T Ochi

    ARTHRITIS AND RHEUMATISM Vol. 41 No. 9 p. S239-S239 1998/09 Research paper, summary (international conference)

  111. Identification of a Minimal 30-Base-Pair Sequence Responsible for Cartilage-Specific Expression of the α2 (XI) Collagen Gene

    TSUMAKI N., KIMURA T., TANAKA K., KIMURA J. H., YAMADA Y., OCHI T.

    Vol. 72 No. 8 1998/08/25

  112. Role of CDMP-1 in Skeletal Morphogenesis : Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation

    TSUMAKI N., THOMAS J. T., LUYTEN F. P., YAMADA Y.

    Vol. 72 No. 8 1998/08/25

  113. II型コラーゲンCプロペプチド過剰発現マウスにおける内軟骨性骨形成の変化

    松井 好人, 中田 研, 木村 友厚, 妻木 範行, 山田 吉彦, 安井 夏生, 片岡 英一郎, 越智 隆弘

    日本整形外科学会雑誌 Vol. 72 No. 8 p. s1567-s1567 1998/08/25

    Publisher: (公社)日本整形外科学会
  114. 軟骨の発生・分化に対する Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) の作用

    妻木 範行, TANAKA K., ARIKAWA HIRASAWA E., THOMAS J. T., 越智 隆弘, LUYTEN F. P., 木村 友厚, YAMADA Y.

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism Vol. 16 No. 2 p. 6-6 1998/07/07

  115. Targeted expression of CDMP-1 in mouse cartilage expands primordial cartilage and enhances chondrocyte differentiation

    Tsumaki N., Tanaka K., Akikawa-Hirasawa E., Thomas J.T., Ochi T., Luyten F.P., Kimura T., Yamada Y.

    Connective tissue Vol. 30 No. 2 p. 162-162 1998/06/05

    Publisher: The Japanese Society for Connective Tissue
  116. Genes in joint disorders

    Kimura Tomoatsu, Tsumaki Noriyuki, Yasui Natsuo, Nakata Ken, Tomita Tetsuya, Kataoka Eiichiro, Ochi Takahiro

    Connective tissue Vol. 30 No. 2 p. 129-129 1998

    Publisher: 日本結合組織学会
  117. Transcriptional regulatory cis-elements of α2(XI) collagen gene

    N. Tsumaki, T. Kimura, Y. Matsui, K. Nakata, T. Ochi

    Connective Tissue Vol. 30 p. 75-79 1998/01/01

  118. Differential in situ Expression of Mouse Pro-a2(XI) Collagen during Development

    SUGIMOTO M

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association Vol. 71 No. 8 1997/08/25

  119. 11型コラ-ゲンの構造と機能 (特集 マトリックス生物学の最前線)

    木村 友厚, 妻木 範行, 越智 隆弘

    生体の科学 Vol. 48 No. 4 p. 254-259 1997/08

    Publisher: 金原一郎記念医学医療振興財団
  120. 軟骨マトリックスの異常と関節破壊

    木村 友厚, 田邊 誠, 中田 研, 妻木 範行, 松井 好人, 越智 隆弘

    リウマチ Vol. 37 No. 2 p. 206-206 1997/04/01

  121. Promoter assay using transgenic mice reveals the presence of cis-acting elements governing tissue and site-specific expression of Col1a2.

    N Tsumaki, M Sugimoto, Y Matsui, K Nakata, T Ochi, T Kimura

    MATRIX BIOLOGY Vol. 15 No. 3 p. 194-194 1996/09 Research paper, summary (international conference)

  122. Alternative Splicing of the Primary Transcripts at the N-propeptide Coding Region of Human Pro-α1(XI) and Pro-α2(XI) Collagen in Cartilaginous Tumors

    MATSUI Y

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association Vol. 70 No. 8 1996/08/25

  123. Collagens and Osteo-chondrogenesis

    KIMURA T

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association Vol. 70 No. 8 1996/08/25

  124. マウスXI型コラーゲンα2鎖遺伝子の軟骨特異的発現にかかわる転写制御領域の解析

    妻木 範行, 木村 友厚, 松井 好人, 杉本 瑞生, 中田 研, 越智 隆弘

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism Vol. 14 No. 2 p. 67-67 1996/06/01

  125. マウス発生過程におけるXI型コラーゲンα2鎖 alternative splicing form の発現と局在

    杉本 瑞生, 妻木 範行, 松井 好人, 中田 研, 木村 友厚, 佐藤 宗彦, 川畑 浩久, 野村 慎太郎, 越智 隆弘

    日本骨代謝学会雑誌 = Japanese journal of bone metabolism Vol. 14 No. 2 p. 161-161 1996/06/01

  126. A common FGFR3 mutation functions as a diagnostic marker for achondroplasia-group disorders in the Japanese population

    MATSUI YOSHITO, KIMURA TOMOATSU, TSUMAKI NORIYUKI, NAKAHARA HARUHIKO, ARAKI NOBUHITO, YASUI NATSUO, OCHI TAKAHIRO

    J. Orthop. Sci. Vol. 1 No. 2 p. 130-135 1996/03/01

  127. PROGRESSIVE DEGENERATION OF ARTICULAR-CARTILAGE AND INTERVERTEBRAL DISCS IN TRANSGENIC MICE BEARING A TYPE-IX COLLAGEN MUTATION

    T KIMURA, K NAKATA, N TSUMAKI, Y MATSUI, T OCHI

    ARTHRITIS AND RHEUMATISM Vol. 38 No. 9 p. 692-692 1995/09 Research paper, summary (international conference)

  128. マウスXI型コラーゲンα2鎖遺伝子転写制御領域の解析 トランスジェニックマウスを用いて

    妻木 範行, 木村 友厚, 中田 研

    日本整形外科学会雑誌 Vol. 69 No. 8 p. s1737-s1737 1995/08/25

    Publisher: (公社)日本整形外科学会
  129. Collagen Genes and Skeletal Disorders

    KIMURA Tomoatsu, TSUMAKI Noriyuki, MATSUI Yoshito

    Vol. 35 No. 3 p. 600-608 1995/06

  130. 骨軟骨コラーゲン異常モデルマウス

    中田 研, 妻木 範行, 木村 友厚

    Molecular Medicine Vol. 臨増 No. マニュアル疾患モデルマウス p. 138-146 1994/12

    Publisher: (株)中山書店
  131. 発生工学を用いた病態動物モデル 軟骨異常トランスジェニックマウスの作製と解析

    中田 研, 妻木 範行, 木村 友厚

    BIO medica Vol. 8 No. 14 p. 1128-1134 1993/12

    Publisher: (株)北隆館
  132. 肩関節外傷性前方不安定症における関節内病変の進行様式

    妻木 範行, 脇谷 滋之, 米田 稔

    肩関節 Vol. 17 No. 1 p. 111-115 1993/09

    Publisher: (一社)日本肩関節学会

Presentations 22

  1. iPS細胞由来髄核様組織を用いた椎間板再生治療法の開発

    妻木 範行

    第24回日本再生医療学会総会 2025/03/20

  2. Mutant activated FGFR3 impairs growth plate chondrocyte dynamics in a Knock-in mouse model of Achondroplasia

    The 1st International Symposium on Life-omics Research 2025/02/02

  3. Crispld1 as a novel cartilage-specific molecule linking mechanical stress and hypoxic responses in primary spongiosa formation

    The 1st International Symposium on Life-omics Research 2025/02/02

  4. Application of iPS cell-derived cartilage to regenerate articular cartilage damag

    2024/12/07

  5. 同種iPS細胞を用いた関節軟骨再生治療の研究と臨床応用

    第39回日本整形外科学会基礎学術集会 2024/10/18

  6. (椎間板ヘルニアの今後の展望)i PS 細胞由来髄核様組織を用いた椎間板再生治療法の開発

    妻木 範行

    第 97 回 日本整形外科学会学術集会 2024/05/24

  7. 同種iPS細胞由来軟骨移植による関節軟骨損傷の再生治療法の開発

    妻木 範行

    第68回日本リウマチ学会総会・学術集会 2024/04/18

  8. 運動器再生医療の現在と未来 「関節軟骨欠損に対する同種iPS細胞由来軟骨移植による再生」

    阿部 健吾, 妻木 範行

    第36回日本軟骨代謝学会 2024/02/16

  9. 内軟骨性骨化におけるCrispld1の機能解明

    山下 晃弘, 妻木 範行

    第36回日本軟骨代謝学会 2024/02/16

  10. 骨格発生と再生治療の研究開発

    妻木 範行

    第 27 回リウマチフォーラム 2024/02/03

  11. 再生医療の基礎開発、臨床応用そして企業とのコラボレーション

    妻木 範行

    第 5 回 再生医療等製品および周辺産業の規制動向討論会 2024/01/06

  12. 軟骨再生医療の最先端 軟骨発生研究とiPS細胞を使った軟骨再生治療法開発

    妻木 範行

    第1回日本膝関節学会 2023/12/08

  13. 同種iPS細胞由来軟骨移植による関節軟 骨損傷の再生治療法の開発

    妻木 範行

    第59回日本移植学会総会 2023/09/22

  14. ヒトiPS細胞由来軟骨を用いた限局した関節軟骨治療法の開発

    山下 晃弘, 妻木 範行

    第65回歯科基礎医学会学術大会 2023/09/17

  15. iPS Cells: A Game Changer Presentation Topic:Stem Cells

    ICRS 2023 17th ICRS World Congress 2023/09/11

  16. 患者由来iPS細胞を用いた変形性膝関節症の病態解析の構想

    根岸 孝寛, 妻木 範行

    第22回運動器科学研究会 2023/09/09

  17. 新規軟骨関連遺伝子Crispld1の機能解明

    山下 晃弘, 妻木 範行

    第22回運動器科学研究会 2023/09/09

  18. 霊長類関節軟骨欠損モデルにおける同種iPS細胞由来軟骨の生着と機能

    阿部 健吾, 妻木 範行

    第41回日本骨代謝学会学術集会 2023/07/27

  19. 同種iPS細胞由来軟骨移植による関節軟骨損傷の再生治療法の開発

    妻木 範行

    第44回日本炎症・再生医学会 2023/07/13

  20. iPS 細胞由来軟骨様髄核による椎間板再生の可能性

    萩澤 宏樹, 釜谷 崇志, 小屋松 冴子, 岡田 誠司, 海渡 貴司, 妻木 範行

    第 13 回 Orthopedic Research Club 2023/06/03

  21. 霊長類膝軟骨欠損モデルにおける同種 iPS 細胞由来軟骨移植による修復

    阿部 健吾, 山下 晃弘, 松田 秀一, 妻木 範行

    第96回日本整形外科学会学術総会 2023/05/12

  22. 再生,創薬による早期関節軟骨損傷・変性の治療方法の開発

    妻木 範行

    第96回日本整形外科学会学術総会 2023/05/12

Works 4

  1. 厚生労働科学研究費補助金 免疫アレルギー疾患予防・治療研究事業

    2006 -

  2. 超音波刺激,人工骨,骨形成因子(BMP)シグナル操作を組み合わせた骨欠損の修復

    2006 -

  3. 軟骨細胞シグナリングとマトリックス転写制御による軟骨形成・分化の解明

    2006 -

  4. 難治性骨折治癒過程におけるBMPシグナル作用機構の解明

    2005 -

Institutional Repository 13

Content Published in the University of Osaka Institutional Repository (OUKA)
  1. Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity

    Abe Kengo, Tsumaki Noriyuki

    Inflammation and Regeneration Vol. 43 No. 1 2023/11/14

  2. Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone

    Hagizawa Hiroki, Koyamatsu Saeko, Okada Seiji, Kaito Takashi, Tsumaki Noriyuki

    Frontiers in Cell and Developmental Biology Vol. 11 2023/05/15

  3. Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

    Abe Kengo, Yamashita Akihiro, Morioka Miho, Horike Nanao, Takei Yoshiaki, Koyamatsu Saeko, Okita Keisuke, Matsuda Shuichi, Tsumaki Noriyuki

    Nature Communications Vol. 14 No. 1 2023/02/20

  4. Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus

    Kamatani Takashi, Hagizawa Hiroki, Yarimitsu Seido, Morioka Miho, Koyamatsu Saeko, Sugimoto Michihiko, Kodama Joe, Yamane Junko, Ishiguro Hiroyuki, Shichino Shigeyuki, Abe Kuniya, Fujibuchi Wataru, Fujie Hiromichi, Kaito Takashi, Tsumaki Noriyuki

    Biomaterials Vol. 284 2022/05/01

  5. Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface

    Okutani Yuki, Abe Kengo, Yamashita Akihiro, Morioka Miho, Matsuda Shuichi, Tsumaki Noriyuki

    Tissue Engineering - Part A Vol. 28 No. 1-2 p. 94-106 2022/01/17

  6. Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice

    Iimori Yuki, Morioka Miho, Koyamatsu Saeko, Tsumaki Noriyuki

    Tissue Engineering - Part A Vol. 27 No. 21-22 p. 1355-1367 2021/11/01

  7. Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells

    Yamashita Akihiro, Tsumaki Noriyuki

    Development Growth and Differentiation Vol. 63 No. 1 p. 72-81 2021/01/07

  8. Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia

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