Cancer immunotherapy targeting Wilms' tumor gene WT1 product

Y Oka, K Udaka, A Tsuboi, OA Elisseeva, H Ogawa, K Aozasa, T Kishimoto, H Sugiyama

JOURNAL OF IMMUNOLOGY　Vol. 164　No. 4　p. 1873-1880　2000/02　Research paper (scientific journal)

Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product

Y Oka, OA Elisseeva, A Tsuboi, H Ogawa, H Tamaki, HF Li, Y Oji, EH Kim, T Soma, M Asada, K Ueda, E Maruya, H Saji, T Kishimoto, K Udaka, H Sugiyama

IMMUNOGENETICS　Vol. 51　No. 2　p. 99-107　2000/02　Research paper (scientific journal)

An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes.

Y Oka, A G Rolink, S Suematsu, T Kishimoto, F Melchers

European journal of immunology　Vol. 25　No. 5　p. 1332-7　1995/05

Immature B cells can pass through a VHDJH/germ line state in the Ig H chain gene rearrangements.

Y Oka, H Sugiyama, S Tsukada, S Kishimoto

Journal of immunology (Baltimore, Md. : 1950)　Vol. 145　No. 1　p. 361-4　1990/07/01　Research paper (scientific journal)

Isolation and characterization of temperature-sensitive mutants of Abelson murine leukaemia virus that exhibit dissociation among morphological transformation, soft agar colony-forming ability and tyrosine kinase activity.

Y Oka, H Sugiyama, S Tsukada, Y Shimizu, H Inoue, A Hakura, S Kishimoto

The Journal of general virology　Vol. 70 ( Pt 9)　p. 2527-32　1989/09　Research paper (scientific journal)

Spontaneous high clonal expansion of Wilms' tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms' tumor gene 1-expressing solid tumor.

Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 74　No. 1　p. 15-15　2024/11/07　Research paper (scientific journal)

WT1発現固形癌患者におけるWT1特異的CTLの自然に発生したクローン性増殖

森本 創世子, 岡 芳弘, 藤木 文博, 田中 ゆきえ, 中田 潤, 中島 博子, 西田 純幸, 保仙 直毅, 坪井 昭博, 尾路 祐介, 杉山 治夫

日本がん免疫学会総会・日本バイオセラピィ学会学術集会総会合同大会プログラム・抄録集　Vol. 28回・37回　p. 154-154　2024/06

Identification of causative fungus from sterile abscess using metagenomics followed by in situ hybridization.

Hiroya Oki, Ryotaro Niwa, Somboonthum Pranee, Daisuke Motooka, Yoshiyuki Onda, Jun Nakata, Hiroko Nakajima, Yoshihiro Oka, Haruo Sugiyama, Yuka Yoshii, Naoyuki Anzai, Shota Nakamura, Tetsuya Iida

Access microbiology　Vol. 6　No. 8　2024　Research paper (scientific journal)

GEM併用WT1ワクチン投与膵癌患者からのWT1^126特異的high avidity TCRの単離

森本 創世子, 藤木 文博, 西田 純幸, 永田 暁教, 中田 潤, 中島 博子, 尾路 祐介, 岡 芳弘, 杉山 治夫

日本臨床免疫学会総会プログラム・抄録集　Vol. 51回　p. 121-121　2023/10

若年健常者は腫瘍関連抗原特異的免疫応答を持つ(Tumor-associated antigen-specific immune responses in healthy young individuals)

高田 恭平, 大植 麻由, 森本 創世子, 中田 潤, 西田 純幸, 藤木 文博, 岡 芳弘, 杉山 治夫, 尾路 祐介

日本癌学会総会記事　Vol. 82回　p. 1021-1021　2023/09

TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析

永田 暁教, 藤木 文博, 森本 創世子, 中田 潤, 西田 純幸, 中島 博子, 橋井 佳子, 坪井 昭博, 岡 芳弘, 尾路 祐介, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 27回　p. 122-122　2023/06

Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs.

Fumihiro Fujiki, Soyoko Morimoto, Yuya Nishida, Satoe Tanii, Nao Aoyama, Miki Inatome, Kento Inoue, Akiko Katsuhara, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 72　No. 7　p. 2347-2356　2023/03/20　Research paper (scientific journal)

WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1

Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, Motoyuki Suzuki, Sumiyuki Nishida, Jun Nakata, Akihiro Tsuboi, Miki Iwai, Sae Hayashi, Rin Imanishi, Sayaka Ikejima, Mizuki Kanegae, Masahiro Iwamoto, Mayu Ikeda, Kento Yagi, Haruka Shimokado, Hiroko Nakajima, Kana Hasegawa, Soyoko Morimoto, Fumihiro Fujiki, Akira Nagahara, Atsushi Tanemura, Yutaka Ueda, Tsunekazu Mizushima, Masato Ohmi, Takayuki Ishida, Manabu Fujimoto, Norio Nonomura, Tadashi Kimura, Hidenori Inohara, Seiji Okada, Haruhiko Kishima, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Haruo Sugiyama

Cancers　Vol. 15　No. 2　p. 393-393　2023/01/06　Research paper (scientific journal)

小児がんに対する免疫療法の現状 小児固形腫瘍に対するWT1ペプチドワクチン療法の有効性と免疫学的解析

橋井 佳子, 細谷 要介, 尾路 祐介, 坪井 昭博, 岡 芳弘, 大薗 恵一, 杉山 治夫

日本癌治療学会学術集会抄録集　Vol. 60回　p. OWS3-3　2022/10

GEM併用WT1ワクチン投与膵癌患者からのWT1^126特異的high-avidity TCRの単離

森本 創世子, 藤木 文博, 西田 純幸, 永田 暁教, 中田 潤, 中島 博子, 尾路 祐介, 岡 芳弘, 杉山 治夫

日本臨床免疫学会総会プログラム・抄録集　Vol. 50回　p. 112-112　2022/10　Research paper (conference, symposium, etc.)

若年健常者におけるがん抗原特異的細胞性免疫応答(TAA-specific cellular immune responses in young, healthy adults)

下門 遥, 高田 恭平, 西田 純幸, 岡 芳弘, 杉山 治夫, 尾路 祐介

日本癌学会総会記事　Vol. 81回　p. P-2173　2022/09　Research paper (conference, symposium, etc.)

WT1蛋白を標的とした小児固形腫瘍に対するがん免疫療法 予後と免疫学的解析

橋井 佳子, 細谷 要介, 岡 芳弘, 尾路 祐介, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 鐘ヶ江 瑞稀, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 26回　p. 140-140　2022/06　Research paper (conference, symposium, etc.)

Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Akie Iehara, Mai Iwai, Seishin Hashiguchi, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Satoshi Yoshihara, Masahiro Manabe, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Takafumi Nakao, Asao Hirose, Masayuki Hino, Shiho Ueda, Katsuto Takenaka, Takashi Masuko, Koichi Akashi, Takahiro Maruno, Susumu Uchiyama, Shinji Takamatsu, Naoki Wada, Eiichi Morii, Shushi Nagamori, Daisuke Motooka, Yoshikatsu Kanai, Yusuke Oji, Tomoyoshi Nakagawa, Noriyuki Kijima, Haruhiko Kishima, Atsuyo Ikeda, Takayuki Ogino, Yasushi Shintani, Tateki Kubo, Emiko Mihara, Kosuke Yusa, Haruo Sugiyama, Junichi Takagi, Eiji Miyoshi, Atsushi Kumanogoh, Naoki Hosen

Science translational medicine　Vol. 14　No. 632　2022/02/16　Research paper (scientific journal)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine.

Shouq Alzaaqi, Norifumi Naka, Kenichiro Hamada, Naoki Hosen, Mizuki Kanegae, Hidetatsu Outani, Mayuko Adachi, Rin Imanishi, Eiichi Morii, Miki Iwai, Jun Nakata, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Oncology letters　Vol. 23　No. 2　p. 65-65　2022/02　Research paper (scientific journal)

T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy.

Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Frontiers in immunology　Vol. 13　p. 935465-935465　2022　Research paper (scientific journal)

Cellular and Humoral Immune Responses Induced by an HLA Class I–restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer

Sumiyuki Nishida, Soyoko Morimoto, Yusuke Oji, Satoshi Morita, Toshiaki Shirakata, Takayuki Enomoto, Akihiro Tsuboi, Yutaka Ueda, Kiyoshi Yoshino, Alzaaqi Shouq, Mizuki Kanegae, Satoshi Ohno, Fumihiro Fujiki, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Tadashi Kimura, Haruo Sugiyama

Journal of Immunotherapy　Vol. 45　No. 1　p. 56-66　2022/01　Research paper (scientific journal)

難治性白血病に対する同種造血幹細胞移植後WT1ペプチドワクチン接種時の免疫応答の解析(WT1-targeteing immunotherapy after allogeneic HSCT in children with refractory acute leukemias)

橋井 佳子, 岡 芳弘, 坂田 尚己, 渡辺 新, 尾路 祐介, 保仙 直毅, 山本 紘司, 服部 聡, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 池島 彩香, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本血液学会学術集会　Vol. 83回　p. OS1-5　2021/09

Identification of mouse helper epitopes for WT1-specific CD4+ T cells.

Hiroko Nakajima, Jun Nakata, Kanako Imafuku, Hiromu Hayashibara, Kazuki Isokawa, Keiko Udaka, Fumihiro Fujiki, Soyoko Morimoto, Kana Hasegawa, Naoki Hosen, Yoshiko Hashii, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 11　p. 3323-3335　2021/07/16　Research paper (scientific journal)

Maintenance of WT1 expression in tumor cells is associated with a good prognosis in malignant glioma patients treated with WT1 peptide vaccine immunotherapy.

Chisato Yokota, Naoki Kagawa, Koji Takano, Yasuyoshi Chiba, Manabu Kinoshita, Noriyuki Kijima, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Akihiro Tsuboi, Shuichi Izumoto, Haruhiko Kishima, Naoya Hashimoto

Cancer immunology, immunotherapy : CII　Vol. 71　No. 1　p. 189-201　2021/06/05　Research paper (scientific journal)

Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies

Chisato Yokota, Jun Nakata, Koji Takano, Hiroko Nakajima, Hiromu Hayashibara, Hikaru Minagawa, Yasuyoshi Chiba, Ryuichi Hirayama, Noriyuki Kijima, Manabu Kinoshita, Yoshiko Hashii, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Kagawa, Haruhiko Kishima

Neuro-Oncology Advances　Vol. 3　No. 1　2021/01/01　Research paper (scientific journal)

Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.

Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Kana Hasegawa, Naoki Hosen, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 1　p. 253-263　2021/01　Research paper (scientific journal)

Imaging assessment of tumor response in the era of immunotherapy

Jun Nakata, Kayako Isohashi, Yoshihiro Oka, Hiroko Nakajima, Soyoko Morimoto, Fumihiro Fujiki, Yusuke Oji, Akihiro Tsuboi, Atsushi Kumanogoh, Naoya Hashimoto, Jun Hatazawa, Haruo Sugiyama

Diagnostics　Vol. 11　No. 6　2021

Enhanced immune reaction resulting from co-vaccination of WT1 helper peptide assessed on PET-CT.

Jun Nakata, Kayako Isohashi, Soyoko Morimoto, Ryota Itou, Takashi Kamiya, Ai Matsuura, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Yoshiko Hasii, Kana Hasegawa, Shinichi Nakatsuka, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Atsushi Kumanogoh, Masaru Shibano, Satoru Munakata, Yusuke Oji, Jun Hatazawa, Haruo Sugiyama

Medicine　Vol. 99　No. 39　2020/09/25　Research paper (scientific journal)

マウス神経膠腫モデルにおけるWT1ワクチン療法と抗PD-1抗体療法の併用による抗腫瘍効果の増強

林原 弘武, 横田 千里, 高野 浩司, 中田 潤, 皆川 光, 中島 博子, 橋井 佳子, 尾路 祐介, 坪井 昭博, 岡 芳弘, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 24回　p. 106-106　2020/09

Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy.

Sae Hayashi, Rin Imanishi, Mayuko Adachi, Sayaka Ikejima, Jun Nakata, Soyoko Morimoto, Fumihiro Fujiki, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Hiroko Nakajima, Kana Hasegawa, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Biomedical reports　Vol. 12　No. 5　p. 244-250　2020/05

Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review.

Yoshiko Hashii, Yoshihiro Oka, Naoki Kagawa, Naoya Hashimoto, Hiroyuki Saitou, Syogo Fukuya, Mizuki Kanegae, Sayaka Ikejima, Yusuke Oji, Keiichi Ozono, Akihiro Tsuboi, Haruo Sugiyama

Frontiers in oncology　Vol. 10　p. 1188-1188　2020

Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.

Sumiyuki Nishida, Akihiro Tsuboi, Atsushi Tanemura, Toshinori Ito, Hiroko Nakajima, Toshiaki Shirakata, Soyoko Morimoto, Fumihiro Fujiki, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Ichiro Kawase, Yoshihiro Oka, Ichiro Azuma, Satoshi Morita, Haruo Sugiyama

Medicine　Vol. 98　No. 33　2019/08　Research paper (scientific journal)

【血液領域における免疫療法と抗体医薬-最近の展開】急性骨髄性白血病に対するWT1ペプチドワクチンの有用性

中田 潤, 中江 吉希, 川上 学, 坪井 昭博, 森本 創世子, 中島 博子, 橋井 佳子, 藤木 文博, 西田 純幸, 長谷川 加奈, 保仙 毅, 尾路 祐介, 岡 芳弘, 杉山 治夫

血液内科　Vol. 79　No. 1　p. 19-25　2019/07

What should we tackle next in acute myeloid leukemia? Wilms tumor gene 1 vaccine therapy would be a promising and versatile strategy for acute myeloid leukemia.

Jun Nakata, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

Expert review of hematology　Vol. 12　No. 4　p. 211-213　2019/04

A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma.

Akihiro Tsuboi, Naoya Hashimoto, Fumihiro Fujiki, Soyoko Morimoto, Naoki Kagawa, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Satoshi Morita, Junichi Sakamoto, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 68　No. 2　p. 331-340　2019/02　Research paper (scientific journal)

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.

Jun Nakata, Hiroko Nakajima, Hiromu Hayashibara, Kanako Imafuku, Soyoko Morimoto, Fumihiro Fujiki, Daisuke Motooka, Daisuke Okuzaki, Kana Hasegawa, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Oncotarget　Vol. 9　No. 89　p. 36029-36038　2018/11/13　Research paper (scientific journal)

【小児医療における診断・治療の進歩2018】治療技術 小児難治性悪性腫瘍に対するWT1ペプチドワクチン療法

橋井 佳子, 岡 芳弘, 杉山 治夫, 大薗 恵一

小児科　Vol. 59　No. 12　p. 1815-1820　2018/11

Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.

Soyoko Morimoto, Fumihiro Fujiki, Kenta Kondo, Hiroko Nakajima, Yoshiki Kobayashi, Miki Inatome, Nao Aoyama, Yuya Nishida, Akihiro Tsuboi, Yoshihiro Oka, Sumiyuki Nishida, Jun Nakata, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

Oncotarget　Vol. 9　No. 75　p. 34132-34141　2018/09/25　Research paper (scientific journal)

Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.

Jun Nakata, Yoshiki Nakae, Manabu Kawakami, Soyoko Morimoto, Daisuke Motooka, Naoki Hosen, Fumihiro Fujiki, Hiroko Nakajima, Kana Hasegawa, Sumiyuki Nishida, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh, Haruo Sugiyama

British journal of haematology　Vol. 182　No. 2　p. 287-290　2018/07

WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies.

Yusuke Oji, Masayoshi Inoue, Yoshito Takeda, Naoki Hosen, Yasushi Shintani, Manabu Kawakami, Takuya Harada, Yui Murakami, Miki Iwai, Mari Fukuda, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Toshiaki Shirakata, Hiroko Nakajima, Kana Hasegawa, Hiroshi Kida, Takashi Kijima, Soyoko Morimoto, Fumihiro Fujiki, Akihiro Tsuboi, Eiichi Morii, Satoshi Morita, Junichi Sakamoto, Atsushi Kumanogoh, Yoshihiro Oka, Meinoshin Okumura, Haruo Sugiyama

International journal of cancer　Vol. 142　No. 11　p. 2375-2382　2018/06/01　Research paper (scientific journal)

Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.

Sumiyuki Nishida, Takeshi Ishikawa, Shinichi Egawa, Shigeo Koido, Hiroaki Yanagimoto, Jun Ishii, Yoshihide Kanno, Satoshi Kokura, Hiroaki Yasuda, Mari Saito Oba, Maho Sato, Soyoko Morimoto, Fumihiro Fujiki, Hidetoshi Eguchi, Hiroaki Nagano, Atsushi Kumanogoh, Michiaki Unno, Masanori Kon, Hideaki Shimada, Kei Ito, Sadamu Homma, Yoshihiro Oka, Satoshi Morita, Haruo Sugiyama

Cancer immunology research　Vol. 6　No. 3　p. 320-331　2018/03　Research paper (scientific journal)

The activated conformation of integrin beta(7) is a novel multiple myeloma-specific target for CAR T cell therapy

Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi, Atsushi Kumanogoh

NATURE MEDICINE　Vol. 23　No. 12　p. 1436-+　2017/12　Research paper (scientific journal)

Wilms' Tumor Gene 1 (WT1) Peptide Vaccine Therapy for Hematological Malignancies: From CTL Epitope Identification to Recent Progress in Clinical Studies Including a Cure-Oriented Strategy

Yoshihiro Oka, Akihiro Tsuboi, Jun Nakata, Sumiyuki Nishida, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

ONCOLOGY RESEARCH AND TREATMENT　Vol. 40　No. 11　p. 682-690　2017/11

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Sebastien Anguille, Ann L. Van de Velde, Evelien L. Smits, Viggo F. Van Tendeloo, Gunnar Juliusson, Nathalie Cools, Griet Nijs, Barbara Stein, Eva Lion, Ann Van Driessche, Irma Vandenbosch, Anke Verlinden, Alain P. Gadisseur, Wilfried A. Schroyens, Ludo Muylle, Katrien Vermeulen, Marie-Berthe Maes, Kathleen Deiteren, Ronald Malfait, Emma Gostick, Martin Lammens, Marie M. Couttenye, Philippe Jorens, Herman Goossens, David A. Price, Kristin Ladell, Yoshihiro Oka, Fumihiro Fujiki, Yusuke Oji, Haruo Sugiyama, Zwi N. Berneman

BLOOD　Vol. 130　No. 15　p. 1713-1721　2017/10　Research paper (scientific journal)

A Zbtb7a proto-oncogene as a novel target for miR-125a

Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji

MOLECULAR CARCINOGENESIS　Vol. 55　No. 12　p. 2001-2009　2016/12　Research paper (scientific journal)

Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.

Satoshi Takashima, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Sumiyuki Nishida, Naoki Hosen, Naoya Tatsumi, Kenji Mizuguchi, Naoya Hashimoto, Yusuke Oji, Akihiro Tsuboi, Atsushi Kumanogoh, Haruo Sugiyama

Future science OA　Vol. 2　No. 4　2016/12　Research paper (scientific journal)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide

Yusuke Oji, Naoya Hashimoto, Akihiro Tsuboi, Yui Murakami, Miki Iwai, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Olga Elisseeva, Ryo Ichinohasama, Junichi Sakamoto, Satoshi Morita, Hiroko Nakajima, Satoshi Takashima, Yoshiki Nakae, Jun Nakata, Manabu Kawakami, Sumiyuki Nishida, Naoki Hosen, Fumihiro Fujiki, Soyoko Morimoto, Mayuko Adachi, Masahiro Iwamoto, Yoshihiro Oka, Toshiki Yoshimine, Haruo Sugiyama

INTERNATIONAL JOURNAL OF CANCER　Vol. 139　No. 6　p. 1391-1401　2016/09　Research paper (scientific journal)

Randomized phase II study of WT1 peptide vaccine plus gemcitabine for advanced pancreatic ductal adenocarcinoma (PDAC): Clinical efficacy and immune response

Nishida Sumiyuki, Ishikawa Takeshi, Kokura Satoshi, Egawa Shinichi, Koido Shigeo, Yasuda Hiroaki, Yanagimoto Hiroaki, Ishii Jun, Kanno Yoshihide, Oba Mari Saito, Sato Maho, Morimoto Soyoko, Eguchi Hidetoshi, Nagano Hiroaki, Homma Sadamu, Oka Yoshihiro, Morita Satoshi, Sugiyama Haruo

JOURNAL OF CLINICAL ONCOLOGY　Vol. 34　No. 15　2016/05/20

Induction of eEF2-specific antitumor CTL responses in vivo by vaccination with eEF2-derived 9mer-peptides

Hiroko Nakajima, Yui Murakami, Eiichi Morii, Toshiki Akao, Naoya Tatsumi, Satoko Odajima, Mari Fukuda, Takao Machitani, Miki Iwai, Sayo Kawata, Nozomi Hojo, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

ONCOLOGY REPORTS　Vol. 35　No. 4　p. 1959-1966　2016/04　Research paper (scientific journal)

An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8(+) T Cells

Kenta Kondo, Fumihiro Fujiki, Hiroko Nakajima, Erika Yatsukawa, Soyoko Morimoto, Naoya Tatsumi, Sumiyuki Nishida, Jun Nakata, Yoshihiro Oka, Akihiro Tsuboi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 39　No. 3　p. 127-139　2016/04　Research paper (scientific journal)

Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Katsuhiko Nakano, Hiroko Kinoshita, Atsushi Okumura, Yuka Fujioka, Rika Urakawa, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eiji Miyoshi, Takako Hirata, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities

N. Tatsumi, N. Hojo, O. Yamada, M. Ogawa, Y. Katsura, S. Kawata, E. Morii, H. Sakamoto, R. Inaba, A. Tsuda, I. Fukuda, N. Moriguchi, H. Hasuwa, M. Okabe, F. Fujiki, S. Nishida, H. Nakajima, A. Tsuboi, Y. Oka, N. Hosen, H. Sugiyama, Y. Oji

Oncogene　Vol. 35　No. 8　p. 1003-1014　2016/02/25　Research paper (scientific journal)

Feasibility of Cancer Immunotherapy with WT1 Peptide Vaccination for Solid and Hematological Malignancies in Children

Akihisa Sawada, Masami Inoue, Osamu Kondo, Kayo Yamada-Nakata, Takashi Ishihara, Yuko Kuwae, Masanori Nishikawa, Yasuhiro Ammori, Akihiro Tsuboi, Yusuke Oji, Maho Koyama-Sato, Yoshihiro Oka, Masahiro Yasui, Haruo Sugiyama, Keisei Kawa

PEDIATRIC BLOOD & CANCER　Vol. 63　No. 2　p. 234-241　2016/02　Research paper (scientific journal)

Wilms tumor 1 peptide vaccination after hematopoietic stem cell transplant in leukemia patients.

Naoki Hosen, Tetsuo Maeda, Yoshiko Hashii, Akihiro Tsuboi, Sumiyuki Nishida, Jun Nakata, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

Stem cell investigation　Vol. 3　p. 90-90　2016　Research paper (scientific journal)

Wilms' tumor gene WT1 promotes homologous recombination-mediated DNA damage repair

Yusuke Oji, Naoya Tatsumi, Junya Kobayashi, Mari Fukuda, Tazu Ueda, Eri Nakano, Chisae Saito, Syohei Shibata, Mihoko Sumikawa, Hisashi Fukushima, Akari Saito, Nozomi Hojo, Miyu Suzuki, Tomoko Hoshikawa, Tsutomu Shimura, Eiichi Morii, Yoshihiro Oka, Naoki Hosen, Kenshi Komatsu, Haruo Sugiyama

MOLECULAR CARCINOGENESIS　Vol. 54　No. 12　p. 1758-1771　2015/12　Research paper (scientific journal)

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 10　No. 12　2015/12　Research paper (scientific journal)

Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients

Yoshiki Nakae, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Toshio Kamiya, Satoshi Takashima, Jun Nakata, Sumiyuki Nishida, Hiroko Nakajima, Naoki Hosen, Akihiro Tsuboi, Taiichi Kyo, Yusuke Oji, Kenji Mizuguchi, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 7　p. 791-804　2015/07　Research paper (scientific journal)

Central Nervous System Tumor:Glioma 脳腫瘍 グリオーマ 脳腫瘍に対するペプチドワクチン療法

橋本 直哉, 香川 尚己, 有田 英之, 坪井 昭博, 岡 芳弘, 尾路 祐介, 杉山 治夫, 吉峰 俊樹

癌と化学療法　Vol. 42　No. 6　p. 687-689　2015/06

Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response

Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 6　p. 707-716　2015/06　Research paper (scientific journal)

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms

Naoya Tatsumi, Nozomi Hojo, Hiroyuki Sakamoto, Rena Inaba, Nahoko Moriguchi, Keiko Matsuno, Mari Fukuda, Akihide Matsumura, Seiji Hayashi, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Haruo Sugiyama, Yusuke Oji

PLOS ONE　Vol. 10　No. 6　2015/06　Research paper (scientific journal)

III. Peptide vaccination therapy against brain tumors

Naoya Hashimoto, Naoki Kagawa, Hideyuki Arita, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Toshiki Yoshimine

Japanese Journal of Cancer and Chemotherapy　Vol. 42　No. 6　p. 687-689　2015/06/01　Research paper (scientific journal)

Transduction of a Novel HLA-DRB1*04:05-restricted, WT1-specific TCR Gene into Human CD4(+) T Cells Confers Killing Activity Against Human Leukemia Cells

Akiko Katsuhara, Fumihiro Fujiki, Nao Aoyama, Satoe Tanii, Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Kenta Kondo, Naoya Tatsumi, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Sumiyuki Nishida, Naoki Hosen, Shinji Sogo, Yusuke Oji, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 35　No. 3　p. 1251-1261　2015/03　Research paper (scientific journal)

Wilms' tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer

Koido Shigeo, Nishida Sumiyuki, Homma Sadamu, Takeda Yutaka, Komita Hideo, Morita Satoshi, Ito Toshinori, Morimoto Soyoko, Oka Yoshihiro, Yanagisawa Satoru, Toyama Yoichi, Ikegami Masahiro, Nagano Hiroaki, Ohkusa Toshifumi, Tajiri Hisao, Sugiyama Haruo

CANCER RESEARCH　Vol. 74　No. 19　2014/10/01

Vaccination strategies to improve outcome of hematopoietic stem cell transplant in leukemia patients: early evidence and future prospects

Naoki Hosen, Tetsuo Maeda, Yoshiko Hashii, Akihiro Tsuboi, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh, Haruo Sugiyama

EXPERT REVIEW OF HEMATOLOGY　Vol. 7　No. 5　p. 671-681　2014/10

WT1 PEPTIDE VACCINATION FOR MALIGNANT GLIOMAS AS A PART OF MULTI-MODAL THERAPY

Hashimoto Naoya, Tsuboi Akihiro, Chiba Yasuyoshi, Hirayama Ryuichi, Takano Koji, Kijima Noriyuki, Oka Yoshihiro, Kagawa Naoki, Izumoto Shuichi, Sugiyama Haruo, Yoshimine Toshiki

NEURO-ONCOLOGY　Vol. 16　2014/07

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity

J. Nakata, K. Nakano, A. Okumura, Y. Mizutani, H. Kinoshita, M. Iwai, K. Hasegawa, S. Morimoto, F. Fujiki, N. Tatsumi, H. Nakajima, Y. Nakae, S. Nishida, A. Tsuboi, Y. Oji, Y. Oka, H. Sugiyama, A. Kumanogoh, N. Hosen

LEUKEMIA　Vol. 28　No. 6　p. 1316-1325　2014/06　Research paper (scientific journal)

The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers

Yusuke Oji, Naoya Tatsumi, Mari Fukuda, Shin-Ichi Nakatsuka, Sayaka Aoyagi, Erika Hirata, Isamu Nanchi, Fumihiro Fujiki, Hiroko Nakajima, Yumiko Yamamoto, Syohei Shibata, Michiyo Nakamura, Kana Hasegawa, Sayaka Takagi, Ikuyo Fukuda, Tomoko Hoshikawa, Yui Murakami, Masahide Mori, Masayoshi Inoue, Tetsuji Naka, Takeshi Tomonaga, Yoshifumi Shimizu, Masashi Nakagawa, Junichi Hasegawa, Riichiro Nezu, Hidenori Inohara, Shuichi Izumoto, Norio Nonomura, Toshiki Yoshimine, Meinoshin Okumura, Eiichi Morii, Hajime Maeda, Sumiyuki Nishida, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 44　No. 5　p. 1461-1469　2014/05　Research paper (scientific journal)

Wilms Tumor Gene ( WT1) Peptide- based Cancer Vaccine Combined With Gemcitabine for Patients With Advanced Pancreatic Cancer

Sumiyuki Nishida, Shigeo Koido, Yutaka Takeda, Sadamu Homma, Hideo Komita, Akitaka Takahara, Satoshi Morita, Toshinori Ito, Soyoko Morimoto, Kazuma Hara, Akihiro Tsuboi, Yoshihiro Oka, Satoru Yanagisawa, Yoichi Toyama, Masahiro Ikegami, Toru Kitagawa, Hidetoshi Eguchi, Hiroshi Wada, Hiroaki Nagano, Jun Nakata, Yoshiki Nakae, Naoki Hosen, Yusuke Oji, Toshio Tanaka, Ichiro Kawase, Atsushi Kumanogoh, Junichi Sakamoto, Yuichiro Doki, Masaki Mori, Toshifumi Ohkusa, Hisao Tajiri, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 37　No. 2　p. 105-114　2014/02　Research paper (scientific journal)

eEF2の癌遺伝子様機能とeEF2特異的免疫応答の誘導(Oncogenic function of eEF2 in cancers and in vivo humoral and in vitro CTL responses against eEF2 protein)

尾路 祐介, 辰巳 直也, 福田 茉莉, 中塚 新一, 藤木 文博, 中島 博子, 長谷川 加奈, 根津 理一郎, 森井 英一, 坪井 昭博, 岡 芳弘, 杉山 治夫

日本癌学会総会記事　Vol. 72回　p. 367-367　2013/10

WT1ペプチドワクチンを用いた小児悪性固形腫瘍に対する第I/II相臨床試験(WT1 based immunotherapy for pediatric patient with solid malignant tumor: Phase I/II clinical trial)

橋井 佳子, 岡 芳弘, 香川 尚己, 宮村 能子, 細谷 要介, 尾路 祐介, 坪井 昭博, 大薗 恵一, 杉山 治夫

日本癌学会総会記事　Vol. 72回　p. 153-153　2013/10

Peptide vaccination therapy targeting wilms' tumor 1 (WTl) gene products against malignant gliomas

Naoya Hashimoto, Yasuyoshi Chiba, Manabu Kinoshita, Naoki Kagawa, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Toshiki Yoshimine

Japanese Journal of Neurosurgery　Vol. 22　No. 8　p. 619-624　2013/08/25　Research paper (scientific journal)

Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine

Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H

BLOOD CANCER JOURNAL　Vol. 3　No. 8　2013/08　Research paper (scientific journal)

Functional human Th17 clones with WT1-specific helper activity

Sho Tachino, Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Soyoko Morimoto, Yu-Hung Lin, Taichi Tamanaka, Kenta Kondo, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 62　No. 4　p. 801-810　2013/04　Research paper (scientific journal)

HLA-DPB1*05:01-restricted WT1 (332)-specific TCR-transduced CD4(+) T Lymphocytes Display a Helper Activity for WT1-specific CTL Induction and a Cytotoxicity Against Leukemia Cells

Yuhung Lin, Fumihiro Fujiki, Akiko Katsuhara, Yoshihiro Oka, Akihiro Tsuboi, Nao Aoyama, Satoe Tanii, Hiroko Nakajima, Naoya Tatsumi, Soyoko Morimoto, Taichi Tamanaka, Sho Tachino, Naoki Hosen, Sumiyuki Nishida, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 36　No. 3　p. 159-170　2013/04　Research paper (scientific journal)

WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial

Takashi Miyatake, Yutaka Ueda, Akiko Morimoto, Takayuki Enomoto, Sumiyuki Nishida, Toshiaki Shirakata, Yoshihiro Oka, Akihiro Tsuboi, Yusuke Oji, Naoki Hosen, Shin-ichi Nakatsuka, Satoshi Morita, Junichi Sakamoto, Haruo Sugiyama, Tadashi Kimura

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY　Vol. 139　No. 3　p. 457-463　2013/03　Research paper (scientific journal)

Identification of a Wilms' tumor 1-derived immunogenic CD4+ T-cell epitope that is recognized in the context of common Caucasian HLA-DR haplotypes

S Anguille, F Fujiki (co-first author, E L Smits, Y Oji, E Lion, Y Oka, Z N Berneman, H Sugiyama

Leukemia　Vol. 27　p. 748-750　2013　Research paper (scientific journal)

Recognition of a Natural WT1 Epitope by a Modified WT1 Peptide-specific T-Cell Receptor

Taichi Tamanaka, Yoshihiro Oka, Fumihiro Fujiki, Akihiro Tsuboi, Akiko Katsuhara, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Yu-Hung Lin, Sho Tachino, Yoshiki Akatsuka, Kiyotaka Kuzushima, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 32　No. 12　p. 5201-5209　2012/12　Research paper (scientific journal)

小児悪性神経膠腫に対するWT1ペプチドワクチン免疫療法

橋井 佳子, 香川 尚己, 橋本 直哉, 坪井 昭博, 岡 芳弘, 尾路 祐介, 楠木 重範, 岡田 秀雄, 杉山 治夫, 大薗 恵一

日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号　Vol. 54回・10回・17回　p. 402-402　2012/11

CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients.

Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H

Leukemia　Vol. 26　No. 9　2012/09　Research paper (scientific journal)

Use of C-11-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma Clinical article

Yasuyoshi Chiba, Manabu Kinoshita, Yoshiko Okita, Akihito Tsuboi, Kayako Isohashi, Naoki Kagawa, Yasunori Fujimoto, Yusuke Oji, Yoshihiro Oka, Eku Shimosegawa, Satoshi Morita, Jun Hatazawa, Haruo Sugiyama, Naoya Hashimoto, Toshiki Yoshimine

JOURNAL OF NEUROSURGERY　Vol. 116　No. 4　p. 835-842　2012/04　Research paper (scientific journal)

Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors.

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

Cancer Sci.　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

Biased usage of T cell receptor ss-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+T cells in patients with solid tumors and healthy donors

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER SCIENCE　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

Vaccination with WT-1 (Wilms' Tumor gene-1) peptide and BCG-CWS in melanoma

Megumi Nishioka, Atsushi Tanemura, Sumiyuki Nishida, Akiko Nakano, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Ichiro Azuma, Haruo Sugiyama, Ichiro Katayama

EUROPEAN JOURNAL OF DERMATOLOGY　Vol. 22　No. 2　p. 258-259　2012/03

WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer

Toshiaki Shirakata, Yoshihiro Oka, Sumiyuki Nishida, Naoki Hosen, Akihiro Tsuboi, Yusuke Oji, Ayako Murao, Hidetaka Tanaka, Shin-Ichi Nakatsuka, Hidenori Inohara, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 32　No. 3　p. 1081-1085　2012/03　Research paper (scientific journal)

CD48 as a novel molecular target for antibody therapy in multiple myeloma

Naoki Hosen, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Yuki Fukuda, Satoshi Kishida, Yoshikazu Matsuoka, Hiroko Nakajima, Manabu Kawakami, Tamotsu Yamagami, Shigeo Fuji, Hiroya Tamaki, Takafumi Nakao, Sumiyuki Nishida, Akihiro Tsuboi, Shinsuke Iida, Masayuki Hino, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama

BRITISH JOURNAL OF HAEMATOLOGY　Vol. 156　No. 2　p. 213-224　2012/01　Research paper (scientific journal)

Enhanced tumor immunity of WT1 peptide vaccination by interferon-beta administration

Hiroko Nakajima, Yoshihiro Oka, Akihiro Tsuboi, Naoya Tatsumi, Yumiko Yamamoto, Fumihiro Fujiki, Zheyu Li, Ayako Murao, Soyoko Morimoto, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Ichiro Kawase, Yoshitaka Isaka, Yusuke Oji, Haruo Sugiyama

VACCINE　Vol. 30　No. 4　p. 722-729　2012/01　Research paper (scientific journal)

WT1 peptide-based immunotherapy following allogeneic stem cell transplantation in pediatric patients with acute leukemia

Yoshiko Hashii, Risa Matsumura, Hisao Yoshida, Emiko Miyashita, Hideaki Ohta, Akihiro Tsuboi, Yusuke Oji, Naoki Hosen, Yoshihiro Oka, Keiichi Ozono, Haruo Sugiyama

Biotherapy　Vol. 25　No. 6　p. 851-856　2011/11/30　Research paper (scientific journal)

Immunotherapy targeting Wilms' tumor 1 peptide for patients with glioblastomas

Naoya Hashimoto, Akihiro Tsuboi, Yasuyoshi Chiba, Yoshihiro Oka, Toshiki Yoshimine, Haruo Sugiyama

Biotherapy　Vol. 25　No. 6　p. 877-882　2011/11/30　Research paper (scientific journal)

【がんペプチドワクチン療法の進歩と課題】同種造血幹細胞移植後の難治性小児血液腫瘍患者におけるWT1ペプチドワクチンを用いた免疫療法

橋井 佳子, 松村 梨紗, 吉田 寿雄, 宮下 恵実子, 太田 秀明, 坪井 昭博, 尾路 祐介, 保仙 直毅, 岡 芳弘, 大薗 恵一, 杉山 治夫

Biotherapy　Vol. 25　No. 6　p. 851-856　2011/11

Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab

Sumiyuki Nishida, Tomio Kawasaki, Hirokazu Kashiwagi, Atsuyoshi Morishima, Yoshihiro Hishitani, Mari Kawai, Toru Hirano, Taeko Ishii, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata, Yoshihiro Oka, Tadamitsu Kishimoto, Toshio Tanaka

MODERN RHEUMATOLOGY　Vol. 21　No. 4　p. 420-422　2011/08　Research paper (scientific journal)

[WT1 peptide-based immunotherapy for the treatment of malignancies: focusing on hematological neoplasms].

Yoshihiro Oka, Akihiro Tsuboi, Sumiyuki Nishida, Naoki Hosen, Jun Nakata, Yoshiko Hashii, Tetsuo Maeda, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 52　No. 5　p. 235-42　2011/05　Research paper (scientific journal)

WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient

Yusuke Oji, Yoshihiro Oka, Sumiyuki Nishida, Akihiro Tsuboi, Manabu Kawakami, Toshiaki Shirakata, Kazuko Takahashi, Ayako Murao, Hiroko Nakajima, Miwako Narita, Masuhiro Takahashi, Satoshi Morita, Junichi Sakamoto, Toshio Tanaka, Ichiro Kawase, Naoki Hosen, Haruo Sugiyama

EUROPEAN JOURNAL OF HAEMATOLOGY　Vol. 85　No. 4　p. 358-360　2010/10　Research paper (scientific journal)

WT1 peptide vaccine, one of the most promising cancer vaccines: its present status and the future prospects

Yoshihiro Oka, Haruo Sugiyama

IMMUNOTHERAPY　Vol. 2　No. 5　p. 591-594　2010/09

Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes

Hideto Tamura, Kazuo Dan, Norio Yokose, Rika Iwakiri, Masatsugu Ohta, Hisashi Sakamaki, Kaoru Tohyama, Asaka Kondo, Hideya Hyodo, Kyoko Nakamura, Taishi Yamashita, Olga A. Elisseeva, Yoshihiro Oka, Yusuke Oji, Haruo Sugiyama, Kiyoyuki Ogata

LEUKEMIA RESEARCH　Vol. 34　No. 8　p. 986-990　2010/08　Research paper (scientific journal)

WT1 Peptide Immunotherapy for Cancer in Children and Young Adults

Yoshiko Hashii, Emiko Sato, Hideaki Ohta, Yoshihiro Oka, Haruo Sugiyama, Keiichi Ozono

PEDIATRIC BLOOD & CANCER　Vol. 55　No. 2　p. 352-355　2010/08　Research paper (scientific journal)

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

Viggo F. Van Tendeloo, Ann Van de Velde, Ann Van Driessche, Nathalie Cools, Sebastien Anguille, Kristin Ladell, Emma Gostick, Katrien Vermeulen, Katrien Pieters, Griet Nijs, Barbara Stein, Evelien L. Smits, Wilfried A. Schroyens, Alain P. Gadisseur, Inge Vrelust, Philippe G. Jorens, Herman Goossens, I. Jolanda de Vries, David A. Price, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama, Zwi N. Berneman

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 31　p. 13824-13829　2010/08　Research paper (scientific journal)

A Clear Correlation between WT1-specific Th Response and Clinical Response in WT1 CTL Epitope Vaccination

Fumihiro Fujiki, Yoshihiro Oka, Mai Kawakatsu, Akihiro Tsuboi, Yukie Tanaka-Harada, Naoki Hosen, Sumiyuki Nishida, Toshiaki Shirakata, Hiroko Nakajima, Naoya Tatsumi, Naoya Hashimoto, Tetsuya Taguchi, Satsuki Ueda, Norio Nonomura, Yutaka Takeda, Toshinori Ito, Akira Myoui, Shuichi Izumoto, Motohiko Maruno, Toshiki Yoshimine, Shinzaburo Noguchi, Akihiko Okuyama, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 30　No. 6　p. 2247-2254　2010/06　Research paper (scientific journal)

Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide

Ryo Ichinohasama, Yusuke Oji, Hisayuki Yokoyama, Kengo Takeuchi, Tohru Fujiwara, Kenichi Ishizawa, Osamu Taniguchi, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama

CANCER SCIENCE　Vol. 101　No. 5　p. 1089-1092　2010/05　Research paper (scientific journal)

Effects of Concomitant Temozolomide and Radiation Therapies on WT1-specific T-cells in Malignant Glioma

Yasuyoshi Chiba, Naoya Hashimoto, Akihiro Tsuboi, Yoshihiro Oka, Ayako Murao, Manabu Kinoshita, Naoki Kagawa, Yusuke Oji, Naoki Hosen, Sumiyuki Nishida, Haruo Sugiyama, Toshiki Yoshimine

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　Vol. 40　No. 5　p. 395-403　2010/05　Research paper (scientific journal)

High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients: an important role of bone marrow as a secondary lymphoid organ.

Ayako Murao, Yoshihiro Oka, Akihiro Tsuboi, Olga A Elisseeva, Yukie Tanaka-Harada, Fumihiro Fujiki, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Toshiaki Shirakata, Nobuyuki Hashimoto, Akira Myoui, Takafumi Ueda, Yoshito Takeda, Tadashi Osaki, Takayuki Enomoto, Hideki Yoshikawa, Tadashi Kimura, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

Cancer Sci.　Vol. 101　No. 4　p. 848-854　2010/04　Research paper (scientific journal)

High frequencies of less differentiated and more proliferative WT1-specific CD8+T cells in bone marrow in tumor-bearing patients: An important role of bone marrow as a secondary lymphoid organ

Ayako Murao, Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Yukie Tanaka-Harada, Fumihiro Fujiki, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Toshiaki Shirakata, Nobuyuki Hashimoto, Akira Myoui, Takafumi Ueda, Yoshito Takeda, Tadashi Osaki, Takayuki Enomoto, Hideki Yoshikawa, Tadashi Kimura, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

CANCER SCIENCE　Vol. 101　No. 4　p. 848-854　2010/04　Research paper (scientific journal)

Prognostic value of WT1 protein expression level and MIB-1 staining index as predictor of response to WT1 immunotherapy in glioblastoma patients

Yasuyoshi Chiba, Naoya Hashimoto, Akihiro Tsuboi, Carter Rabo, Yoshihiro Oka, Manabu Kinoshita, Naoki Kagawa, Yusuke Oji, Haruo Sugiyama, Toshiki Yoshimine

BRAIN TUMOR PATHOLOGY　Vol. 27　No. 1　p. 29-34　2010/04　Research paper (scientific journal)

Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies.

Yukie Tanaka-Harada, Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Takamasa Katagiri, Olga A Elisseeva, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Fumihiro Fujiki, Ayako Murao, Hiroko Nakajima, Yusuke Oji, Yoshinobu Kanda, Ichiro Kawase, Haruo Sugiyama

Cancer Sci.　Vol. 101　No. 3　p. 594-600　2010/03　Research paper (scientific journal)

Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8(+) T cells in patients with myeloid malignancies

Yukie Tanaka-Harada, Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Takamasa Katagiri, Olga A. Elisseeva, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Fumihiro Fujiki, Ayako Murao, Hiroko Nakajima, Yusuke Oji, Yoshinobu Kanda, Ichiro Kawase, Haruo Sugiyama

CANCER SCIENCE　Vol. 101　No. 3　p. 594-600　2010/03　Research paper (scientific journal)

WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE

Miwako Narita, Masayoshi Masuko, Tohri Kurasaki, Toshiki Kitajima, Shoko Takenouchi, Anri Saitoh, Norihiro Watanabe, Tatsuo Furukawa, Ken Toba, Ichiro Fuse, Yoshifusa Aizawa, Manabu Kawakami, Yoshihiro Oka, Haruo Sugiyama, Masuhiro Takahashi

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES　Vol. 7　No. 2　p. 72-81　2010　Research paper (scientific journal)

Prognostic Significance of WT1 mRNA and Anti-WT1 Antibody Levels in Peripheral Blood in Patients with Myelodysplastic Syndromes.

Tamura Hideto, Dan Kazuo, Yokose Norio, Iwakiri Rika, Ohta Masatsugu, Sakamaki Hisashi, Tohyama Kaoru, Asaka Kondo, Hyodo Hideya, Nakamura Kyoko, Yamashita Taishi, Elisseeva Olga A, Oka Yoshihiro, Oji Yusuke, Sugiyama Haruo, Ogata Kiyoyuki

BLOOD　Vol. 114　No. 22　2009/11/20

Wilms' Tumor 1 (WT1) Peptide Immunotherapy for Gynecological Malignancy

Satoshi Ohno, Satoru Kyo, Subaru Myojo, Satoshi Dohi, Junko Ishizaki, Ken-Ichi Miyamoto, Satoshi Morita, Jun-Ichi Sakamoto, Takayuki Enomoto, Tadashi Kimura, Yoshihiro Oka, Akihiro Tsuboi, Haruo Sugiyama, Masaki Inoue

ANTICANCER RESEARCH　Vol. 29　No. 11　p. 4779-4784　2009/11　Research paper (scientific journal)

WT1 Peptide Vaccine as a Paradigm for "Cancer Antigen-Derived Peptide"-Based Immunotherapy for Malignancies: Successful Induction of Anti-Cancer Effect by Vaccination with a Single Kind of WT1 Peptide

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Zheyu Li, Hiroko Nakajima, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY　Vol. 9　No. 7　p. 787-797　2009/09　Research paper (scientific journal)

WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor

Yusuke Oji, Yayoi Kitamura, Eriko Kamino, Aiko Kitano, Noriyoshi Sawabata, Masayoshi Inoue, Masahide Mori, Shin-ichi Nakatsuka, Nao Sakaguchi, Kaori Miyazaki, Michiyo Nakamura, Ikuyo Fukuda, Junya Nakamura, Naoya Tatsumi, Tetsuya Takakuwa, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Akihiro Tsuboi, Riichiro Nezu, Hajime Maeda, Yoshihiro Oka, Ichiro Kawase, Katsuyuki Aozasa, Meinoshin Okumura, Shinichiro Miyoshi, Haruo Sugiyama

INTERNATIONAL JOURNAL OF CANCER　Vol. 125　No. 2　p. 381-387　2009/07　Research paper (scientific journal)

Immunotherapy targeting the Wilms' tumor 1 gene product for patients with malignant brain tumors

Naoya Hashimoto, Akihiro Tsuboi, Yasuyoshi Chiba, Shuichi Izumoto, Yoshihiro Oka, Toshiki Yoshimine, Haruo Sugiyama

Brain and Nerve　Vol. 61　No. 7　p. 805-814　2009/07

Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle

Junya Nakamura, Sayaka Aoyagi, Isamu Nanchi, Shin-Ichi Nakatsuka, Erika Hirata, Shohei Shibata, Mari Fukuda, Yumiko Yamamoto, Ikuyo Fukuda, Naoya Tatsumi, Tazu Ueda, Fumihiro Fujiki, Masaya Nomura, Sumiyuki Nishida, Toshiaki Shirakata, Naoki Hosen, Akihoro Tsuboi, Yoshihiro Oka, Riichiro Nezu, Masaki Mori, Yuichiro Doki, Katsuyuki Aozasa, Haruo Sugiyama, Yusuke Oji

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 34　No. 5　p. 1181-1189　2009/05　Research paper (scientific journal)

WT1 peptide vaccination for the treatment of hematological malignancies: the present status and future direction.

Oka Y, Tsuboi A, Shirakata T, Hosen N, Nishida S, Oji Y, Sugiyama H

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 50　No. 5　p. 352-357　2009/05　Research paper (scientific journal)

TREATMENT OF A PATIENT IN A RELAPSE AFTER BONE MARROW TRANSPLANTATION FOR ACUTE LYMPHOBLASTIC LEUKEMIA WITH THE SYSTEMIC ADMINISTRATION OF ALLOGENEIC LYMPHOKINE-ACTIVATED KILLER CELLS AND RECOMBINANT INTERLEUKIN-2

Toshihisa Komori, Haruo Sugiyama, Hiroyasu Ogawa, Yoshihiro Oka, Seigou Miyake, Toshihiro Soma, Yoshihiko Tani, Yusaku Minami, Keita Kunisada, Tohru Masaoka, Susumu Kishimoto

European Journal of Haematology　Vol. 43　No. 2　p. 184-185　2009/04/24　Research paper (scientific journal)

WT1 peptide vaccination therapy targeting hematological malignancies and solid cancers

Yoshihiro Oka, Haruo Sugiyama

Biotherapy　Vol. 23　No. 2　p. 170-177　2009/03　Research paper (international conference proceedings)

WT1 (WILMS TUMOR 1) PEPTIDE IMMUNOTHERAPY FOR CHILDHOOD RHABDOMYOSARCOMA: A Case Report

Hideaki Ohta, Yoshiko Hashii, Akihiro Yoneda, Sachiko Takizawa, Shigenori Kusuki, Sadao Tokimasa, Masahiro Fukuzawa, Akihiro Tsuboi, Ayako Murao, Yoshihiro Oka, Yusuke Oji, Katsuyuki Aozasa, Shin-ichi Nakatsuka, Haruo Sugiyama, Keiichi Ozono

PEDIATRIC HEMATOLOGY AND ONCOLOGY　Vol. 26　No. 1　p. 74-83　2009　Research paper (scientific journal)

"Cancer Antigen WT1 Protein-Derived Peptide"-Based Treatment of Cancer - Toward the Further Development

Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Hiroko Nakajima, Zheyu Li, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

CURRENT MEDICINAL CHEMISTRY　Vol. 15　No. 29　p. 3052-3061　2008/12

A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells

Fumihiro Fujiki, Yoshihiro Oka, Mai Kawakatsu, Akihiro Tsuboi, Hiroko Nakajima, Olga A. Elisseeva, Yukie Harada, Zheyu Li, Naoko Tatsumi, Eriko Kamino, Toshiaki Shirakata, Sumiyuki Nishida, Yuki Taniguchi, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 52　No. 12　p. 591-600　2008/12　Research paper (scientific journal)

Differential radiation sensitivity to morphological, functional and molecular changes of human thyroid tissues and bone marrow cells maintained in SCID mice

Taisei Nomura, Tadashi Hongyo, Hiroo Nakajima, Li Ya Lia, Mukh Syaifudin, Shigeki Adachi, Haruko Ryo, Rajamanickam Baskar, Kazuyasu Fukuda, Yoshihiro Oka, Haruo Sugiyama, Fumio Matsuzuka

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS　Vol. 657　No. 1　p. 68-76　2008/11　Research paper (scientific journal)

Differential radiation sensitivity to morphological, functional and molecular changes of human thyroid tissues and bone marrow cells maintained in SCID mice.

Nomura T, Hongyo T, Nakajima H, Li LY, Syaifudin M, Adachi S, Ryo H, Baskar R, Fukuda K, Oka Y, Sugiyama H, Matsuzuka F

Mutation research　Vol. 657　No. 1　p. 68-76　2008/11

Identification of a WT1 protein-derived peptide, WT1(187), as a HLA-A*0206-restricted, WT1-specific CTL epitope

Zheyu Li, Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Yukie Harada, Hiroko Nakajima, Tomoki Masuda, Yoko Fukuda, Mai Kawakatsu, Soyoko Morimoto, Takamasa Katagiri, Naoya Tatsumi, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yutaka Kawakami, Keiko Udaka, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 52　No. 11　p. 551-558　2008/11　Research paper (scientific journal)

[Cancer antigen WT1-targeting treatment for the malignancies].

Oka Y, Kawase I

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology　Vol. 31　No. 5　p. 375-382　2008/10

Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme

Shuichi Izumoto, Akihiro Tsuboi, Yoshihiro Oka, Tsuyoshi Suzuki, Tetsuo Hashiba, Naoki Kagawa, Naoya Hashimoto, Motohiko Maruno, Olga A. Elisseeva, Toshiaki Shirakata, Manabu Kawakami, Yusuke Oji, Sumiyuki Nishida, Satoshi Ohno, Ichiro Kawase, Jun Hatazawa, Shin-icih Nakatsuka, Katsuyuki Aozasa, Satoshi Morita, Junichi Sakamoto, Haruo Sugiyama, Toshiki Yosihmine

JOURNAL OF NEUROSURGERY　Vol. 108　No. 5　p. 963-971　2008/05　Research paper (scientific journal)

Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors

Naoya Tatsumi, Yusuke Oji, Naoko Tsuji, Asako Tsuda, Mari Higashio, Sayaka Aoyagi, Ikuyo Fukuda, Ken Ito, Junya Nakamura, Satoshi Takashima, Yayoi Kitamura, Saori Miyav, Tanyarat Jomgeow, Zheyu Li, Toshiaki Shirakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama

INTERNATIONAL JOURNAL OF ONCOLOGY　Vol. 32　No. 3　p. 701-711　2008/03　Research paper (scientific journal)

Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma

Akihiro Tsuboi, Yoshihiro Oka, Hiroko Nakajima, Yoko Fukuda, Olga A. Elisseeva, Satoshi Yoshihara, Naoki Hosen, Atsushi Ogata, Katsuyuki Kito, Fumihiro Fujiki, Sumiyuki Nishida, Toshiaki Shirakata, Satoshi Ohno, Masaki Yasukawa, Yusuke Oji, Manabu Kawakami, Satoshi Morita, Junichi Sakamoto, Keiko Udaka, Ichiro Kawase, Haruo Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 86　No. 5　p. 414-417　2007/12　Research paper (scientific journal)

Clinical and immunologic responses to very low-dose vaccination with WT1 peptide (5 mu g/body) in a patient with chronic myelomonocytic leukemia

Manabu Kawakami, Yoshihiro Oka, Akihiro Tsuboi, Yukie Harada, Olga A. Elisseeva, Yoshio Furukawa, Machiko Tsukaguchi, Toshiaki Shirakata, Sumiyuki Nishida, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 85　No. 5　p. 426-429　2007/06　Research paper (scientific journal)

WT1 peptide cancer vaccine for patients with hematopoietic malignancies and solid cancers.

Oka Y, Tsuboi A, Elisseeva OA, Nakajima H, Fujiki F, Kawakami M, Shirakata T, Nishida S, Hosen N, Oji Y, Kawase I, Sugiyama H

TheScientificWorldJournal　Vol. 7　p. 649-665　2007/05

Identification and characterization of a WT1 (Wilms tumor gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes

Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Manabu Kawakami, Mai Kawakatsu, Hiroko Nakajima, Olga A. Elisseeva, Yukie Harada, Ken Ito, Zheyu Li, Naoya Tatsumi, Nao Sakaguchi, Tatsuya Fujioka, Tomoki Masuda, Masaki Yasukawa, Keiko Udaka, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 30　No. 3　p. 282-293　2007/04　Research paper (scientific journal)

WT1 peptide cancer vaccine for patients with hematopoietic malignancies and solid cancers

Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

THESCIENTIFICWORLDJOURNAL　Vol. 7　p. 649-665　2007　Research paper (scientific journal)

The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis.

Hosen N, Shirakata T, Nishida S, Yanagihara M, Tsuboi A, Kawakami M, Oji Y, Oka Y, Okabe M, Tan B, Sugiyama H, Weissman IL

Leukemia　Vol. 21　No. 8　p. 1783-1791　2007　Research paper (scientific journal)

WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma

Tatsuo Iiyama, Keiko Udaka, Sachihiko Takeda, Tamotsu Takeuchi, Yoshihiro C. Adachi, Yuji Ohtsuki, Akihiro Tsuboi, Shin-ichi Nakatsuka, Olga A. Elisseeva, Yusuke Oji, Manabu Kawakami, Hiroko Nakajima, Sumiyuki Nishida, Toshiaki Shirakata, Yoshihiro Oka, Taro Shuin, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 51　No. 5　p. 519-530　2007　Research paper (scientific journal)

Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway.

Ito K, Oji Y, Tatsumi N, Shimizu S, Kanai Y, Nakazawa T, Asada M, Jomgeow T, Aoyagi S, Nakano Y, Tamaki H, Sakaguchi N, Shirakata T, Nishida S, Kawakami M, Tsuboi A, Oka Y, Tsujimoto Y, Sugiyama H

Oncogene　Vol. 25　No. 30　p. 4217-4229　2006/07　Research paper (scientific journal)

A case of alpha-thalassemia-2 associated with pulmonary infarction

Seiji Hayashi, Hiroto Matsuoka, Teruo Harano, Keiko Harano, Hiroshi Nakahara, Isao Tachibana, Hiroshi Kida, Tornio Kawasaki, Shingo Kyotani, Yoshihiro Oka, Mitsunori Sakatani, Ichiro Kawase

LUNG　Vol. 184　No. 4　p. 223-227　2006/07　Research paper (scientific journal)

Immunohistochemical detection of WT1 protein in a variety of cancer cells

S Nakatsuka, Y Oji, T Horiuchi, T Kanda, M Kitagawa, T Takeuchi, K Kawano, Y Kuwae, A Yamauchi, M Okumura, Y Kitamura, Y Oka, Kawase, I, H Sugiyama, K Aozasa

MODERN PATHOLOGY　Vol. 19　No. 6　p. 804-814　2006/06　Research paper (scientific journal)

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

S Nishida, N Hosen, T Shirakata, K Kanato, M Yanagihara, S Nakatsuka, Y Hoshida, T Nakazawa, Y Harada, N Tatsumi, A Tsuboi, M Kawakami, Y Oka, Y Oji, K Aozasa, Kawase, I, H Sugiyama

BLOOD　Vol. 107　No. 8　p. 3303-3312　2006/04　Research paper (scientific journal)

A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: Safety assessment based on the phase I data

S Morita, Y Oka, A Tsuboi, M Kawakami, M Maruno, S Izumoto, T Osaki, T Taguchi, T Ueda, A Myoui, S Nishida, T Shirakata, S Ohno, Y Oji, K Aozasa, J Hatazawa, K Udaka, H Yoshikawa, T Yoshimine, S Noguchi, Kawase, I, SI Nakatsuka, H Sugiyama, J Sakamoto

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　Vol. 36　No. 4　p. 231-236　2006/04　Research paper (scientific journal)

Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro

T Jomgeow, Y Oji, N Tsuji, Y Ikeda, K Ito, A Tsuda, T Nakazawa, N Tatsumi, N Sakaguchi, S Takashima, T Shirakata, S Nishida, N Hosen, M Kawakami, A Tsuboi, Y Oka, K Itoh, H Sugiyama

CANCER SCIENCE　Vol. 97　No. 4　p. 259-270　2006/04　Research paper (scientific journal)

OP-302 WT1抗原を標的とした泌尿器科癌に対するペプチドワクチン療法の第I/II相臨床試験(一般演題口演,第94回日本泌尿器科学会総会)

飯山 達雄, 宇高 恵子, 竹内 保, 大朏 祐治, 中島 博子, 岡 芳弘, 坪井 昭博, 尾路 祐介, 杉山 治夫, 執印 太郎

日本泌尿器科学会雑誌　Vol. 97　No. 2　p. 356-356　2006

A novel direct competitive repopulation assay for human hematopoietic stem cells using NOD/SCID mice

T. Tatekawa, H. Ogawa, M. Kawakami, Y. Oka, K. Yasukawa, H. Sugiyama, I. Kawase, T. Soma

Cytotherapy　Vol. 8　No. 4　p. 390-398　2006

WT1(235), a ninemer peptide derived from Wilms' tumor gene product, is a candidate peptide for the vaccination of HLA-A*0201-positive patients with hematopoietic malignancies

ZY Li, Y Oka, A Tsuboi, T Masuda, N Tatsumi, M Kawakami, T Fujioka, N Sakaguchi, H Nakajima, F Fujiki, K Udaka, Y Oji, Kawase, I, H Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 82　No. 5　p. 458-459　2005/12

A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis

M Kawakami, J Nakata, N Ohguro, S Yoshihara, T Inoue, T Tatekawa, K Ikegame, Y Oka, Kawase, I, H Ogawa

EUROPEAN JOURNAL OF HAEMATOLOGY　Vol. 75　No. 4　p. 352-354　2005/10　Research paper (scientific journal)

Generation of tumor-specific, HLA class I-restricted human Th1 and Tc1 cells by cell engineering with tumor peptide-specific T-cell receptor genes

T Tsuji, M Yasukawa, J Matsuzaki, T Ohkuri, K Chamoto, D Wakita, T Azuma, H Niiya, H Miyoshi, K Kuzushima, Y Oka, H Sugiyama, H Ikeda, T Nishimura

BLOOD　Vol. 106　No. 2　p. 470-476　2005/07　Research paper (scientific journal)

Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.

Wu F, Oka Y, Tsuboi A, Elisseeva OA, Ogata K, Nakajima H, Fujiki F, Masuda T, Murakami M, Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K　Vol. 19　p. 268-274　2005/02

The Wilms' tumor gene WT1 is a common marker of progenitor cells in fetal liver

K Kanato, N Hosen, M Yanagihara, N Nakagata, T Shirakata, T Nakazawa, S Nishida, A Tsuboi, M Kawakami, T Masuda, Y Oka, Y Oji, A IJpenberg, ND Hastie, H Sugiyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 326　No. 4　p. 836-843　2005/01　Research paper (scientific journal)

Unmanipulated reduced-intensity stem cell transplantation from a haploidentical donor mismatched at 3 HLA antigens to a patient with leukemic transformation of myelodysplastic syndrome: Successful second transplantation after graft rejection

EH Kim, K Ikegame, M Kawakami, S Nishida, T Fujioka, Y Taniguchi, T Masuda, Y Oka, Kawase, I, H Ogawa

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 80　No. 5　p. 449-452　2004/12　Research paper (scientific journal)

Successful treatment of tacrolimus (FK506)-related leukoencephalopathy with cerebral hemorrhage in a patient who underwent nonmyeloablative stem cell transplantation.

Hiroya Tamaki, Manabu Kawakami, Kazuhiro Ikegame, Kenichiro Iio, Yu Harada, Kazuo Hatanaka, Yoshihiro Oka, Ichiro Kawase, Hiroyasu Ogawa

International journal of hematology　Vol. 80　No. 3　p. 291-4　2004/10

Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors

Y Oji, T Suzuki, Y Nakano, M Maruno, S Nakatsuka, T Jomgeow, S Abeno, N Tatsumi, A Yokota, S Aoyagi, T Nakazawa, K Ito, K Kanato, T Shirakata, S Nishida, N Hosen, M Kawakami, A Tsuboi, Y Oka, K Aozasa, T Yoshimine, H Sugiyama

CANCER SCIENCE　Vol. 95　No. 10　p. 822-827　2004/10　Research paper (scientific journal)

Overexpression of the Wilms' tumor gene WT1 in esophageal cancer

Y Oji, M Yano, Y Nakano, S Abeno, S Nakatsuka, A Ikeba, T Yasuda, Y Fujiwara, S Takiguchi, H Yamamoto, S Fujita, K Kanato, K Ito, T Jomgeow, M Kawakami, A Tsuboi, T Shirakata, S Nishida, N Hosen, Y Oka, K Aozasa, M Monden, H Sugiyama

ANTICANCER RESEARCH　Vol. 24　No. 5B　p. 3103-3108　2004/09　Research paper (scientific journal)

Powerful graft-versus-leukemia effects exerted by HLA-haploidentical grafts engrafted with a reduced-intensity regimen for relapse following myeloablative HLA-matched transplantation.

Hiroyasu Ogawa, Kazuhiro Ikegame, Manabu Kawakami, Akihiro Tsuboi, Eui Ho Kim, Naoki Hosen, Masaki Murakami, Tatsuya Fujioka, Tomoki Masuda, Yuki Taniguchi, Satoshi Yoshihara, Toyoshi Tatekawa, Yoshihiro Oka, Ichiro Kawase, Toshihiro Soma, Yusuke Oji

Transplantation　Vol. 78　No. 3　p. 488-9　2004/08/15

Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma

Y Oji, S Nakamori, M Fujikawa, SI Nakatsuka, A Yokota, N Tatsumi, S Abeno, A Ikeba, S Takashima, M Tsujie, H Yamamoto, M Sakon, R Nezu, K Kawano, S Nishida, K Ikegame, M Kawakami, A Tsuboi, Y Oka, K Yoshikawa, K Aozasa, M Monden, H Sugiyama

CANCER SCIENCE　Vol. 95　No. 7　p. 583-587　2004/07　Research paper (scientific journal)

Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34(+)CD38(-) cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells

M Kawakami, T Kimura, Y Kishimoto, T Tatekawa, Y Baba, T Nishizaki, N Matsuzaki, Y Taniguchi, S Yoshihara, K Ikegame, T Shirakata, S Nishida, T Masuda, N Hosen, A Tsuboi, Y Oji, Y Oka, H Ogawa, Y Sonoda, H Sugiyama, Kawase, I, T Soma

LEUKEMIA　Vol. 18　No. 5　p. 912-921　2004/05　Research paper (scientific journal)

Allogeneic bone marrow transplantation with non-T-cell-depleted marrow from two HLA-antigen-mismatched related donors.

Hiroyasu Ogawa, Kazuhiro Ikegame, Manabu Kawakami, Yuki Taniguchi, Yoshihiro Oka, Ichiro Kawase

Haematologica　Vol. 89　No. 3　p. 373-5　2004/03

Successful treatment of life-threatening human herpesvirus-6 encephalitis with donor lymphocyte infusion in a patient who had undergone human leukocyte antigen-haploidentical nonmyeloablative stem cell transplantation

S Yoshihara, R Kato, T Inoue, H Myagawa, J Sashihara, M Kawakami, K Ikegame, Y Oka, H Sugiyama, Kawase, I, H Ogawa

TRANSPLANTATION　Vol. 77　No. 6　p. 835-838　2004/03　Research paper (scientific journal)

Absence of mutations in the Wilms' tumor gene WT1 in primary breast cancer

Y Oji, Y Miyoshi, E Kiyotoh, S Koga, Y Nakano, A Ando, N Hosen, A Tsuboi, M Kawakami, K Ikegame, Y Oka, H Ogawa, S Noguchi, H Sugiyama

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　Vol. 34　No. 2　p. 74-77　2004/02　Research paper (scientific journal)

Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y Oji, S Miyoshi, E Takahashi, S Koga, Y Nakano, Y Shintani, H Hirabayashi, A Matsumura, K Iuchi, K Ito, Y Kishimoto, A Tsuboi, K Ikegame, N Hosen, Y Oka, H Ogawa, H Maeda, S Hayashi, Kawase, I, H Sugiyama

NEOPLASMA　Vol. 51　No. 1　p. 17-20　2004　Research paper (scientific journal)

Identification of a gene element essential for leukemia-specific expression of transgenes

N. Hosen, M. Yanagihara, T. Nakazawa, K. Kanato, S. Nishida, T. Shirakata, M. Asada, T. Masuda, Y. Taniguchi, M. Kawakami, A. Tsuboi, K. Ikegame, Y. Oka, H. Ogawa, I. Kawase, Y. Oji, H. Sugiyama

Leukemia　Vol. 18　p. 415-419　2004/01/01

WT1 peptide-based immunotherapy for patients with lung cancer: Report of two cases

A Tsuboi, Y Oka, T Osaki, T Kumagai, Tachibana, I, S Hayashi, M Murakami, H Nakajima, OA Elisseeva, W Fei, T Masuda, M Yasukawa, Y Oji, M Kawakami, N Hosen, K Ikegame, S Yoshihara, K Udaka, S Nakatsuka, K Aozasa, L Kawase, H Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 48　No. 3　p. 175-184　2004　Research paper (scientific journal)

Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1)

H Tamaki, M Mishima, M Kawakami, A Tsuboi, EH Kim, N Hosen, K Ikegame, M Murakami, T Fujioka, T Masuda, Y Taniguchi, S Nishida, K Osumi, T Soma, Y Oji, Y Oka, Kawase, I, H Sugiyama, H Ogawa

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 78　No. 4　p. 349-356　2003/11　Research paper (scientific journal)

Successful engraftment of HLA-haploidentical related transplants using nonmyeloablative conditioning with fludarabine, busulfan and anti-T-lymphocyte globulin

H Tamaki, K Ikegame, M Kawakami, T Fujioka, A Tsuboi, Y Oji, Y Oka, H Sugiyama, Kawase, I, H Ogawa

LEUKEMIA　Vol. 17　No. 10　p. 2052-2054　2003/10

Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma

Y Oji, H Yamamoto, M Nomura, Y Nakano, A Ikeba, S Nakatsuka, S Abeno, E Kiyotoh, T Jomgeow, M Sekimoto, R Nezu, Y Yoshikawa, Y Inoue, N Hosen, M Kawakami, A Tsuboi, Y Oka, H Ogawa, S Souda, K Aozasa, M Monden, H Sugiyama

CANCER SCIENCE　Vol. 94　No. 8　p. 712-717　2003/08　Research paper (scientific journal)

[Cancer immunotherapy targeting WT1 product which overexpressess in various kinds of malignant neoplasms].

Oka Y, Tsuboi A, Sugiyama H

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 48　No. 11 Suppl　p. 1663-1670　2003/08　Research paper (scientific journal)

Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer

Y Oji, Y Miyoshi, S Koga, Y Nakano, A Ando, S Nakatsuka, A Ikeba, E Takahashi, N Sakaguchi, A Yokota, N Hosen, K Ikegame, M Kawakami, A Tsuboi, Y Oka, H Ogawa, K Aozasa, S Noguchi, H Sugiyama

CANCER SCIENCE　Vol. 94　No. 7　p. 606-611　2003/07　Research paper (scientific journal)

Successful treatment of bcr/abl-positive acute mixed lineage leukemia by unmanipulated bone marrow transplantation from an HLA-haploidentical (3-antigen-mismatched) cousin

K Ikegame, C Mukouchi, A Kunitomi, Y Konaka, M Kawakami, S Nishida, Y Taniguchi, T Fujioka, T Masuda, M Murakami, N Hosen, EH Kim, A Tsuboi, Y Oji, Y Oka, H Sugiyama, Kawase, I, H Ogawa

BONE MARROW TRANSPLANTATION　Vol. 31　No. 12　p. 1165-1168　2003/06　Research paper (scientific journal)

Overexpression of the Wilms tumor gene WT1 in head and neck squamous cell carcinoma

Y Oji, H Inohara, M Nakazawa, Y Nakano, S Akahani, S Nakatsuka, S Koga, A Ikeba, S Abeno, Y Honjo, Y Yamamoto, S Iwai, K Yoshida, Y Oka, H Ogawa, J Yoshida, K Aozasa, T Kubo, H Sugiyama

CANCER SCIENCE　Vol. 94　No. 6　p. 523-529　2003/06　Research paper (scientific journal)

The lck promoter-driven expression of the Wilms tumor gene WT1 blocks intrathymic differentiation of T-lineage cells

H Li, Y Oka, A Tsuboi, T Yamagami, T Miyazaki, S Yusa, K Kawasaki, Y Kishimoto, M Asada, H Nakajima, K Kanato, S Nishida, T Masuda, M Murakami, N Hosen, M Kawakami, H Ogawa, F Melchers, Kawase, I, Y Oji, H Sugiyama

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 77　No. 5　p. 463-470　2003/06　Research paper (scientific journal)

The effect on the proliferation and apoptosis of alloreactive T cells of cell dose in a murine MHC-mismatched hematopoietic cell transplantation model

T Fujioka, Y Taniguchi, T Masuda, S Nishida, K Ikegame, M Kawakami, A Tsuboi, N Hosen, M Murakami, Y Oji, Y Oka, H Sugiyama, Kawase, I, H Ogawa

TRANSPLANT IMMUNOLOGY　Vol. 11　No. 2　p. 187-195　2003/04　Research paper (scientific journal)

Successful treatment of refractory T-cell acute lymphoblastic leukemia by unmanipulated stem cell transplantation from an HLA 3-loci mismatched (haploidentical) sibling

K Ikegame, Y Tanji, N Kitai, H Tamaki, M Kawakami, T Fujioka, Y Oka, E Maruya, H Saji, H Sugiyama, H Ogawa

BONE MARROW TRANSPLANTATION　Vol. 31　No. 6　p. 507-510　2003/03　Research paper (scientific journal)

WT1遺伝子の甲状腺癌における過剰発現

浅田 桃太郎, 尾路 祐介, 三好 康雄, 中塚 伸一, 中野 陽子, 岡 芳弘, 小川 啓恭, 青笹 克之, 野口 眞三郎, 杉山 治夫

日本癌学会総会記事　Vol. 61回　p. 245-245　2002/10

Antilung cancer effect of WT1-specific cytotoxic T lymphocytes

M Makita, A Hiraki, T Azuma, A Tsuboi, Y Oka, H Sugiyama, S Fujita, M Tanimoto, M Harada, M Yasukawa

CLINICAL CANCER RESEARCH　Vol. 8　No. 8　p. 2626-2631　2002/08　Research paper (scientific journal)

Cellular and humoral immune responses against WT1 products overexpressed in hematopoietic malignancies

OKA Yoshihiro

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 43　No. 7　p. 505-514　2002/07/30

Combination of tacrolimus, methotrexate, and methylprednisolone prevents acute but not chronic graft-versus-host disease in unrelated bone marrow transplantation.

Ogawa H, Soma T, Hosen N, Tatekawa T, Tsuboi A, Oji Y, Tamaki H, Kawakami M, Ikegame K, Murakami M, Fujioka T, Kim EH, Oka Y, Sugiyama H

Transplantation　Vol. 74　No. 2　p. 236-243　2002/07

Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers

Y Oji, S Miyoshi, H Maeda, S Hayashi, H Tamaki, SI Nakatsuka, M Yao, E Takahashi, Y Nakano, H Hirabayashi, Y Shintani, Y Oka, A Tsuboi, N Hosen, M Asada, T Fujioka, M Murakami, K Kanato, M Motomura, EH Kim, M Kawakami, K Ikegame, H Ogawa, K Aozasa, Kawase, I, H Sugiyama

INTERNATIONAL JOURNAL OF CANCER　Vol. 100　No. 3　p. 297-303　2002/07　Research paper (scientific journal)

Very low frequencies of human normal CD34(+) haematopoietic progenitor cells express the Wilms' tumour gene WT1 at levels similar to those in leukaemia cells

N Hosen, Y Sonoda, Y Oji, T Kimura, H Minamiguchi, H Tamaki, M Kawakami, M Asada, K Kanato, M Motomura, M Murakami, T Fujioka, T Masuda, EH Kim, A Tsuboi, Y Oka, T Soma, H Ogawa, H Sugiyama

BRITISH JOURNAL OF HAEMATOLOGY　Vol. 116　No. 2　p. 409-420　2002/02　Research paper (scientific journal)

WT1 as a Novel Target Antigen for Cancer Immunotherapy

Y. Oka, A. Tsuboi, O. A. Elisseeva, K. Udaka, H. Sugiyama

CURRENT CANCER DRUG TARGETS　Vol. 2　No. 1　p. 45-54　2002　Research paper (scientific journal)

Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination

A Tsuboi, Y Oka, H Ogawa, OA Elisseeva, HF Li, K Kawasaki, K Aozasa, T Kishmoto, K Udaka, H Sugiyama

JOURNAL OF CLINICAL IMMUNOLOGY　Vol. 20　No. 3　p. 195-202　2000/05　Research paper (scientific journal)

Efficient induction of peptide-specific cytotoxic T lymphocytes by LPS-activated spleen cells

K Kakugawa, K Udaka, K Nakashima, K Inaba, Y Oka, H Sugiyama, H Tamamura, H Yamagishi

MICROBIOLOGY AND IMMUNOLOGY　Vol. 44　No. 2　p. 123-133　2000　Research paper (scientific journal)

Successful treatment of relapsed T-cell non-Hodgkin's lymphoma with allogeneic peripheral blood stem cell transplantation with double conditioning

Y Oji, Y Oka, T Tatekawa, T Soma, T Matsunashi, T Yamagami, A Tsuboi, H Tamaki, EH Kim, H Sugiyama, H Ogawa

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 69　No. 4　p. 263-267　1999/06　Research paper (scientific journal)

Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)

A Tsuboi, Y Oka, H Ogawa, OA Elisseeva, H Tamaki, Y Oji, EH Kim, T Soma, T Tatekawa, M Kawakami, T Kishimoto, H Sugiyama

LEUKEMIA RESEARCH　Vol. 23　No. 5　p. 499-505　1999/05　Research paper (scientific journal)

The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes

H Tamaki, H Ogawa, K Ohyashiki, JH Ohyashiki, H Iwama, K Inoue, T Soma, Y Oka, T Tatekawa, Y Oji, A Tsuboi, EH Kim, M Kawakami, K Fuchigami, M Tomonaga, K Toyama, K Aozasa, T Kishimoto, H Sugiyama

LEUKEMIA　Vol. 13　No. 3　p. 393-399　1999/03　Research paper (scientific journal)

Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth

Y Oji, H Ogawa, H Tamaki, Y Oka, A Tsuboi, EH Kim, T Soma, T Tatekawa, M Kawakami, M Asada, T Kishimoto, H Sugiyama

JAPANESE JOURNAL OF CANCER RESEARCH　Vol. 90　No. 2　p. 194-204　1999/02　Research paper (scientific journal)

Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells

K Inoue, H Tamaki, H Ogawa, Y Oka, T Soma, T Tatekawa, Y Oji, A Tsuboi, EH Kim, M Kawakami, T Akiyama, T Kishimoto, H Sugiyama

BLOOD　Vol. 91　No. 8　p. 2969-2976　1998/04　Research paper (scientific journal)

Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia

K Inoue, H Ogawa, Y Sonoda, T Kimura, H Sakabe, Y Oka, S Miyake, H Tamaki, Y Oji, T Yamagami, T Tatekawa, T Soma, T Kishimoto, H Sugiyama

BLOOD　Vol. 89　No. 4　p. 1405-1412　1997/02　Research paper (scientific journal)

Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.

Y Oka, A G Rolink, J Andersson, M Kamanaka, J Uchida, T Yasui, T Kishimoto, H Kikutani, F Melchers

International immunology　Vol. 8　No. 11　p. 1675-85　1996/11　Research paper (scientific journal)

ISOLATION OF A CDNA CLONE ENCODING A NOVEL MEMBRANE-PROTEIN EXPRESSED IN LYMPHOCYTES

Y SHIMIZU, H OGAWA, Y OKA, R MIZUNO, S SAKODA, T KISHIMOTO, H SUGIYAMA

FEBS LETTERS　Vol. 355　No. 1　p. 30-34　1994/11　Research paper (scientific journal)

EXPRESSION OF THE INTERLEUKIN-6 (IL-6), IL-6 RECEPTOR, AND GP130 GENES IN ACUTE-LEUKEMIA

K INOUE, H SUGIYAMA, H OGAWA, T YAMAGAMI, T AZUMA, Y OKA, H MIWA, K KITA, A HIRAOKA, T MASAOKA, K NASU, T KYO, H DOHY, J HARA, A KANAMARU, T KISHIMOTO

BLOOD　Vol. 84　No. 8　p. 2672-2680　1994/10　Research paper (scientific journal)

CYCLIC REGULATION OF B220 ANTIGEN EXPRESSION IN IMMATURE B-CELL LINES

Y OKA, Y SHIMIZU, S TSUKADA, H SUGIYAMA

IMMUNOLOGY AND CELL BIOLOGY　Vol. 72　No. 1　p. 75-78　1994/02　Research paper (scientific journal)

Pre-B cells adhere to fibronectin via interactions of integrin α5/αv with RGDS as well as of integrin α4 with two distinct V region sequences at its different binding sites

Seiji Narumlya, Yoshiko Abe, Yasumichi Kita, Kensuke Miyake, Kiichiro Nakajima, Takushi X. Watanabe, Yoshihiro Oka, Haruo Sugiyama, Hideo Yagita, Ko Okumura, Toshiyuki Hamaoka, Hlroml Fujlwara

International Immunology　Vol. 6　No. 1　p. 139-147　1994/01　Research paper (scientific journal)

A novel mutation within the kinase domain of v-abl gene responsible for temperature-sensitive colony-forming ability in soft agar.

T Soma, S Tsukada, Y Oka, T Kishimoto, H Sugiyama

Virology　Vol. 193　No. 2　p. 967-70　1993/04　Research paper (scientific journal)

The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links

Takashi Tanaka, Tamotsu Yamagami, Yoshihiro Oka, Taisei Nomura, Haruo Sugiyama

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis　Vol. 288　No. 2　p. 277-280　1993　Research paper (scientific journal)

NUCLEOTIDE DELETION OF T-CELL RECEPTOR V-GAMMA-2 AND J-GAMMA-2 CODING SEQUENCES AT V-GAMMA-2-J-GAMMA-2 JUNCTIONS IN IMMATURE B-CELL LINES

S TSUKADA, Y OKA, H SUGIYAMA

MOLECULAR IMMUNOLOGY　Vol. 29　No. 7-8　p. 857-861　1992/07　Research paper (scientific journal)

CONTINUING V-GAMMA-2 TO J-GAMMA-2 REARRANGEMENTS OF MURINE T-CELL RECEPTOR GAMMA GENES IN A B-COMMITTED IMMATURE CELL-LINE

S TSUKADA, Y OKA, H SUGIYAMA

MOLECULAR IMMUNOLOGY　Vol. 29　No. 3　p. 401-409　1992/03　Research paper (scientific journal)

REGULATION OF THY-1 GENE-EXPRESSION BY THE METHYLATION OF THE 5' REGION OF THY-1 GENE AND INTRACELLULAR REGULATORY FACTORS IN IMMATURE B-CELLS

Y SHIMIZU, Y OKA, H OGAWA, T KISHIMOTO, H SUGIYAMA

IMMUNOLOGICAL INVESTIGATIONS　Vol. 21　No. 3　p. 183-191　1992　Research paper (scientific journal)

TRANSITORY EXPRESSION OF THY-1 ANTIGEN IN IMMATURE B-CELL LINES

Y OKA, Y SHIMIZU, S TSUKADA, H SUGIYAMA

IMMUNOLOGICAL INVESTIGATIONS　Vol. 21　No. 1　p. 85-92　1992　Research paper (scientific journal)

UNLINKED REGULATION OF CELL-GROWTH AND DIFFERENTIATION IN IMMATURE B-CELL LINES

Y OKA, H SUGIYAMA, S TSUKADA, H INOUE, A HAKURA, S KISHIMOTO

CELLULAR IMMUNOLOGY　Vol. 130　No. 1　p. 42-49　1990/10　Research paper (scientific journal)

Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16.1, the most 5' D segment and DQ52, the most JH-proximal D segment.

S Tsukada, H Sugiyama, Y Oka, S Kishimoto

Journal of immunology (Baltimore, Md. : 1950)　Vol. 144　No. 10　p. 4053-9　1990/05/15　Research paper (scientific journal)

Severe erythroid hypoplasia controlled by immunosuppressive therapy after autologous bone marrow transplantation in a patient with non-Hodgkin's lymphoma.

M. Hirata, H. Sugiyama, M. Nakagawa, Y. Oka, T. Komori, T. Yamagami, T. Soma, H. Ogawa, Y. Minami, S. Tsukada

Clinical transplants　1989/12

TREATMENT OF A PATIENT IN A RELAPSE AFTER BONE-MARROW TRANSPLANTATION FOR ACUTE LYMPHOBLASTIC-LEUKEMIA WITH THE SYSTEMIC ADMINISTRATION OF ALLOGENEIC LYMPHOKINE-ACTIVATED KILLER CELLS AND RECOMBINANT INTERLEUKIN-2

T KOMORI, H SUGIYAMA, H OGAWA, Y OKA, S MIYAKE, T SOMA, Y TANI, Y MINAMI, K KUNISADA, T MASAOKA, S KISHIMOTO

EUROPEAN JOURNAL OF HAEMATOLOGY　Vol. 43　No. 2　p. 184-185　1989/08

Class switching from γ3 to γ2b in a murine pre-B cell line

Tani Yoshihiko, Sugiyama Haruo, Maeda Toyoki, Miyake Seigou, Oka Yoshihiro, Ogawa Hiroyasu, Komori Toshihisa, Soma Toshihiro, Kishimoto Susumu

Molecular Immunology　Vol. 25　No. 2　p. 127-136　1988　Research paper (scientific journal)

Selective use of the VHQ52 family in functional VH to DJH rearrangements in a b precursor cell line

Haruo Sugiyama, Toyoki Maeda, Yoshihiko Tani, Seigou Miyake, Yoshihiro Oka, Toshihisa Komori, Hiroyasu Ogawa, Toshihiro Soma, Yusaku Minami, Nobuo Sakato, Susumu Kishimoto

Journal of Experimental Medicine　Vol. 166　No. 2　p. 607-612　1987/08/01　Research paper (scientific journal)

START OF MU-CHAIN PRODUCTION BY THE FURTHER 2-STEP REARRANGEMENTS OF IMMUNOGLOBULIN HEAVY-CHAIN GENES ON ONE CHROMOSOME FROM A DJH/DJH CONFIGURATION IN AN ABELSON VIRUS-TRANSFORMED CELL-LINE - EVIDENCE OF SECONDARY DJH COMPLEX-FORMATION

T MAEDA, H SUGIYAMA, Y TANI, S MIYAKE, Y OKA, H OGAWA, T KOMORI, T SOMA, S KISHIMOTO

JOURNAL OF IMMUNOLOGY　Vol. 138　No. 7　p. 2305-2310　1987/04　Research paper (scientific journal)

Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product

T. Maeda, M. K. Owada, H. Sugiyama, S. Miyake, Y. Tani, H. Ogawa, Y. Oka, T. Komori, T. Soma, S. Kishimoto, J. Seki, N. Sakato, A. Hakura

Cell Differentiation　Vol. 20　No. 4　p. 263-269　1987　Research paper (scientific journal)

REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES AND T3 EXPRESSION IN THE ABSENCE OF REARRANGEMENT OF T-CELL RECEPTOR BETA-CHAIN GENE IN A PATIENT WITH T-CELL MALIGNANT-LYMPHOMA

H OGAWA, H SUGIYAMA, Y OKA, T MAEDA, T KOMORI, Y TANI, S MIYAKE, T SOMA, R MAEKURA, C YUTANI, T MASAOKA, S KISHIMOTO

LEUKEMIA RESEARCH　Vol. 10　No. 12　p. 1369-1375　1986　Research paper (scientific journal)

Effects of respiratory movement on the amplitude and configuration of H-Wave.

Y. Ohnuki, T. Nakayama, Y. Higashimoto, Y. Oka

Medical Journal of Osaka University　Vol. 31　p. 63-65　1981