Visualization of trans homophilic interaction of clustered protocadherin in neurons

Natsumi Hoshino, Takashi Kanadome, Tomomi Takasugi, Mizuho Itoh, Ryosuke Kaneko, Yukiko U. Inoue, Takayoshi Inoue, Takahiro Hirabayashi, Masahiko Watanabe, Tomoki Matsuda, Takeharu Nagai, Etsuko Tarusawa, Takeshi Yagi

Proceedings of the National Academy of Sciences　Vol. 120　No. 38　2023/09/11　Research paper (scientific journal)

Visualization of trans-interactions of a protocadherin-α between processes originating from single neurons

Takashi Kanadome, Natsumi Hoshino, Takeharu Nagai, Takeshi Yagi, Tomoki Matsuda

iScience　Vol. 26　No. 7　p. 107238-107238　2023/07　Research paper (scientific journal)

Emergence of rhythmic chunking in complex stepping of mice

Kojiro Hirokane, Toru Nakamura, Yasuo Kubota, Dan Hu, Takeshi Yagi, Ann M. Graybiel, Takashi Kitsukawa

iScience　Vol. 26　No. 5　p. 106765-106765　2023/05　Research paper (scientific journal)

Microglia enable cross-modal plasticity by removing inhibitory synapses

Akari Hashimoto, Nanami Kawamura, Etsuko Tarusawa, Ikuko Takeda, Yuki Aoyama, Nobuhiko Ohno, Mio Inoue, Mai Kagamiuchi, Daisuke Kato, Mami Matsumoto, Yoshihiro Hasegawa, Junichi Nabekura, Anne Schaefer, Andrew J. Moorhouse, Takeshi Yagi, Hiroaki Wake

Cell Reports　Vol. 42　No. 5　p. 112383-112383　2023/05　Research paper (scientific journal)

Imbalanced expression of clustered protocadherins in pre- and post-synaptic compartments of CA1 pyramidal cells during hippocampal development

Etsuko Tarusawa, Saki Hasegawa, Daisuke Noda, Nanami Kawamura, Yugo Fukazawa, Masahiko Watanabe, Takahiro Hirabayashi, Takeshi Yagi

2023/04/15

Double mutation of claudin‐1 and claudin‐3 causes alopecia in infant mice

Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita

Annals of the New York Academy of Sciences　Vol. 1523　No. 1　p. 51-61　2023/03/31　Research paper (scientific journal)

Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

Hiroaki Kobayashi, Kenji Takemoto, Makoto Sanbo, Masumi Hirabayashi, Takahiro Hirabayashi, Teruyoshi Hirayama, Hiroshi Kiyonari, Takaya Abe, Takeshi Yagi

iScience　Vol. 26　No. 1　p. 105766-105766　2023/01　Research paper (scientific journal)

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites.

Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi

Acta neuropathologica communications　Vol. 10　No. 1　p. 172-172　2022/11/29　Research paper (scientific journal)

Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice.

Arikuni Uchimura, Hirotaka Matsumoto, Yasunari Satoh, Yohei Minakuchi, Sayaka Wakayama, Teruhiko Wakayama, Mayumi Higuchi, Masakazu Hashimoto, Ryutaro Fukumura, Atsushi Toyoda, Yoichi Gondo, Takeshi Yagi

Genome research　Vol. 32　No. 5　p. 945-955　2022/05　Research paper (scientific journal)

Development of FRET-based indicators for visualizing homophilic trans interaction of a clustered protocadherin.

Takashi Kanadome, Natsumi Hoshino, Takeharu Nagai, Tomoki Matsuda, Takeshi Yagi

Scientific reports　Vol. 11　No. 1　p. 22237-22237　2021/11/15　Research paper (scientific journal)

Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.

Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 40　No. 47　p. 9012-9027　2020/11/18　Research paper (scientific journal)

Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.

Yuki Komoto, Takahito Ohshiro, Takeshi Yoshida, Etsuko Tarusawa, Takeshi Yagi, Takashi Washio, Masateru Taniguchi

Scientific reports　Vol. 10　No. 1　p. 11244-11244　2020/07/09　Research paper (scientific journal)

Dopamine D1 and muscarinic acetylcholine receptors in dorsal striatum are required for high speed running.

Toru Nakamura, Luis Carl Rios, Takeshi Yagi, Toshikuni Sasaoka, Takashi Kitsukawa

Neuroscience research　Vol. 156　p. 50-57　2020/07　Research paper (scientific journal)

Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.

Komoto Y, Ohshiro T, Yoshida T, Tarusawa E, Yagi T, Washio T, Taniguchi M

Sci Rep.　Vol. 10　No. 1　2020/07

Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination.

Hirotaka Asai, Noriaki Ohkawa, Yoshito Saitoh, Khaled Ghandour, Emi Murayama, Hirofumi Nishizono, Mina Matsuo, Teruyoshi Hirayama, Ryosuke Kaneko, Shin-Ichi Muramatsu, Takeshi Yagi, Kaoru Inokuchi

Molecular brain　Vol. 13　No. 1　p. 7-7　2020/01/20　Research paper (scientific journal)

Pcdhb deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination.

Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu S, Yagi T, Inokuchi K

Mol Brain　Vol. 13　No. 1　p. 7-7　2020/01　Research paper (scientific journal)

Skilled Movements in Mice Require Inhibition of Corticospinal Axon Collateral Formation in the Spinal Cord by Semaphorin Signaling.

Gu Z, Ueno M, Klinefelter K, Mamidi M, Yagi T, Yoshida Y

J Neuroscience　Vol. 39　No. 45　p. 8885-8899　2019/11　Research paper (scientific journal)

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development

Matías Alvarez-Saavedra, Keqin Yan, Yves De Repentigny, Lukas E. Hashem, Nidhi Chaudary, Shihab Sarwar, Doo Yang, Ilya Ioshikhes, Rashmi Kothary, Teruyoshi Hirayama, Takeshi Yagi, David J. Picketts

Frontiers in Molecular Neuroscience　Vol. 12　2019/10　Research paper (scientific journal)

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

Zhicheng Shao, Haneul Noh, Woong Bin Kim, Peiyan Ni, Christine Nguyen, Sarah E Cote, Elizabeth Noyes, Joyce Zhao, Teagan Parsons, James M Park, Kelvin Zheng, Joshua J Park, Joseph T Coyle, Daniel R Weinberger, Richard E Straub, Karen F Berman, Jose Apud, Dost Ongur, Bruce M Cohen, Donna L McPhie, Judith L Rapoport, Roy H Perlis, Thomas A Lanz, Hualin Simon Xi, Changhong Yin, Weihua Huang, Teruyoshi Hirayama, Emi Fukuda, Takeshi Yagi, Sulagna Ghosh, Kevin C Eggan, Hae-Young Kim, Leonard M Eisenberg, Alexander A Moghadam, Patric K Stanton, Jun-Hyeong Cho, Sangmi Chung

Nature neuroscience　Vol. 22　No. 2　p. 229-242　2019/02　Research paper (scientific journal)

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Zhicheng Shao, Haneul Noh, Woong Bin Kim, Peiyan Ni, Christine Nguyen, Sarah E. Cote, Elizabeth Noyes, Joyce Zhao, Teagan Parsons, James M. Park, Kelvin Zheng, Joshua J. Park, Joseph T. Coyle, Daniel R. Weinberger, Richard E. Straub, Karen F. Berman, Jose Apud, Dost Ongur, Bruce M. Cohen, Donna L. McPhie, Judith L. Rapoport, Roy H. Perlis, Thomas A. Lanz, Hualin Simon Xi, Changhong Yin, Weihua Huang, Teruyoshi Hirayama, Emi Fukuda, Takeshi Yagi, Sulagna Ghosh, Kevin C. Eggan, Hae-Young Kim, Leonard M. Eisenberg, Alexander A. Moghadam, Patric K. Stanton, Jun-Hyeong Cho, Sangmi Chung

Nature Neuroscience　Vol. 22　No. 2　p. 229-242　2019/02　Research paper (scientific journal)

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.

Matías Alvarez-Saavedra, Keqin Yan, Yves De Repentigny, Lukas E Hashem, Nidhi Chaudary, Shihab Sarwar, Doo Yang, Ilya Ioshikhes, Rashmi Kothary, Teruyoshi Hirayama, Takeshi Yagi, David J Picketts

Frontiers in molecular neuroscience　Vol. 12　p. 243-243　2019　Research paper (scientific journal)

Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice

Tatsuya Yamagishi, Kohei Yoshitake, Daiki Kamatani, Kenji Watanabe, Hiroaki Tsukano, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Arata Horii, Takeshi Yagi, Katsuei Shibuki

Scientific Reports　Vol. 8　No. 1　2018/12　Research paper (scientific journal)

Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice.

Tatsuya Yamagishi, Kohei Yoshitake, Daiki Kamatani, Kenji Watanabe, Hiroaki Tsukano, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Arata Horii, Takeshi Yagi, Katsuei Shibuki

Scientific reports　Vol. 8　No. 1　p. 9616-9616　2018/06/25　Research paper (scientific journal)

ニューロンIDの可視化 クラスター型プロトカドヘリンの発現解析

金子 涼輔, 阿部 学, 高鶴 裕介, 渡辺 雅彦, 崎村 建司, 柳川 右千夫, 八木 健

生命科学系学会合同年次大会　Vol. 2017年度　p. [4LT08-1196)]　2017/12

Protocadherin-αC2 is required for diffuse projections of serotonergic axons.

Shota Katori, Yukiko Noguchi-Katori, Atsushi Okayama, Yoshimi Kawamura, Wenshu Luo, Kenji Sakimura, Takahiro Hirabayashi, Takuji Iwasato, Takeshi Yagi

Scientific reports　Vol. 7　No. 1　p. 15908-15908　2017/11/21　Research paper (scientific journal)

Protocadherin-alpha C2 is required for diffuse projections of serotonergic axons

Shota Katori, Yukiko Noguchi-Katori, Atsushi Okayama, Yoshimi Kawamura, Wenshu Luo, Kenji Sakimura, Takahiro Hirabayashi, Takuji Iwasato, Takeshi Yagi

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/11　Research paper (scientific journal)

Regulation of clustered protocadherin genes in individual neurons.

Teruyoshi Hirayama, Takeshi Yagi

Seminars in cell & developmental biology　Vol. 69　p. 122-130　2017/09　Research paper (scientific journal)

Regulation of clustered protocadherin genes in individual neurons

Teruyoshi Hirayama, Takeshi Yagi

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY　Vol. 69　p. 122-130　2017/09

Genome Stability by DNA Polymerase β in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development.

Kohei Onishi, Akiko Uyeda, Mitsuhiro Shida, Teruyoshi Hirayama, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 37　No. 35　p. 8444-8458　2017/08/30　Research paper (scientific journal)

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S Kassim, Behnam Javidfar, Brigham J Hartley, Lisa Kleofas, Royce B Park, Benoit Labonte, Seok-Man Ho, Sandhya Chandrasekaran, Catherine Do, Brianna R Ramirez, Cyril J Peter, Julia T C W, Brian M Safaie, Hirofumi Morishita, Panos Roussos, Eric J Nestler, Anne Schaefer, Benjamin Tycko, Kristen J Brennand, Takeshi Yagi, Li Shen, Schahram Akbarian

Nature genetics　Vol. 49　No. 8　p. 1239-1250　2017/08　Research paper (scientific journal)

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain

Yan Jiang, Yong-Hwee Eddie Loh, Prashanth Rajarajan, Teruyoshi Hirayama, Will Liao, Bibi S. Kassim, Behnam Javidfar, Brigham J. Hartley, Lisa Kleofas, Royce B. Park, Benoit Labonte, Seok-Man Ho, Sandhya Chandrasekaran, Catherine Do, Brianna R. Ramirez, Cyril J. Peter, T. C. W. Julia, Brian M. Safaie, Hirofumi Morishita, Panos Roussos, Eric J. Nestler, Anne Schaefer, Benjamin Tycko, Kristen J. Brennand, Takeshi Yagi, Li Shen, Schahram Akbarian

NATURE GENETICS　Vol. 49　No. 8　p. 1239-+　2017/08　Research paper (scientific journal)

Genome Stability by DNA Polymerase beta in Neural Progenitors Contributes to Neuronal Differentiation in Cortical Development

Kohei Onishi, Akiko Uyeda, Mitsuhiro Shida, Teruyoshi Hirayama, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo

JOURNAL OF NEUROSCIENCE　Vol. 37　No. 35　p. 8444-8458　2017/08　Research paper (scientific journal)

Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M Strittmatter

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 37　No. 30　p. 7125-7139　2017/07/26　Research paper (scientific journal)

Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells.

Ryuichi Tatsumi, Takahiro Suzuki, Mai-Khoi Q Do, Yuki Ohya, Judy E Anderson, Ayumi Shibata, Mai Kawaguchi, Shunpei Ohya, Hideaki Ohtsubo, Wataru Mizunoya, Shoko Sawano, Yusuke Komiya, Riho Ichitsubo, Koichi Ojima, Shin-Ichiro Nishimatsu, Tsutomu Nohno, Yutaka Ohsawa, Yoshihide Sunada, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Takanori Nishimura, Takeshi Yagi, Ronald E Allen

Stem cells (Dayton, Ohio)　Vol. 35　No. 7　p. 1815-1834　2017/07　Research paper (scientific journal)

Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase

Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M. Strittmatter

JOURNAL OF NEUROSCIENCE　Vol. 37　No. 30　p. 7125-7139　2017/07　Research paper (scientific journal)

Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells

Ryuichi Tatsumi, Takahiro Suzuki, Mai-Khoi Q. Do, Yuki Ohya, Judy E. Anderson, Ayumi Shibata, Mai Kawaguchi, Shunpei Ohya, Hideaki Ohtsubo, Wataru Mizunoya, Shoko Sawano, Yusuke Komiya, Riho Ichitsubo, Koichi Ojima, Shin-ichiro Nishimatsu, Tsutomu Nohno, Yutaka Ohsawa, Yoshihide Sunada, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Takanori Nishimura, Takeshi Yagi, Ronald E. Allen

STEM CELLS　Vol. 35　No. 7　p. 1815-1834　2017/07　Research paper (scientific journal)

Learning new sequential stepping patterns requires striatal plasticity during the earliest phase of acquisition.

Toru Nakamura, Masatoshi Nagata, Takeshi Yagi, Ann M Graybiel, Tetsuo Yamamori, Takashi Kitsukawa

The European journal of neuroscience　Vol. 45　No. 7　p. 901-911　2017/04　Research paper (scientific journal)

Learning New Sequential Stepping Patterns Requires Striatal Plasticity during the Earliest Phase of Acquisition

Nakamura T, Nagata M, Yagi T, Graybiel AM, Yamamori T, Kitsukawa T

The European journal of neuroscience　Vol. 45　No. 7　p. 901-911　2017/04　Research paper (scientific journal)

Clustered protocadherin are required for building functional neural circuits.

Hasegawa S, Kobayashi H, Kumagai M, Nishimaru H, Tarusawa E, Kanda H, Sanbo M, Yoshimura Y, Hirabayashi M, Hirabayashi T, Yagi T

Frontiers in Molecular Neuroscience　Vol. 10:　2017/04　Research paper (scientific journal)

Clustered Protocadherins Are Required for Building Functional Neural Circuits.

Sonoko Hasegawa, Hiroaki Kobayashi, Makiko Kumagai, Hiroshi Nishimaru, Etsuko Tarusawa, Hiro Kanda, Makoto Sanbo, Yumiko Yoshimura, Masumi Hirabayashi, Takahiro Hirabayashi, Takeshi Yagi

Frontiers in molecular neuroscience　Vol. 10　p. 114-114　2017　Research paper (scientific journal)

Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.

Etsuko Tarusawa, Makoto Sanbo, Atsushi Okayama, Toshio Miyashita, Takashi Kitsukawa, Teruyoshi Hirayama, Takahiro Hirabayashi, Sonoko Hasegawa, Ryosuke Kaneko, Shunsuke Toyoda, Toshihiro Kobayashi, Megumi Kato-Itoh, Hiromitsu Nakauchi, Masumi Hirabayashi, Takeshi Yagi, Yumiko Yoshimura

BMC biology　Vol. 14　No. 1　p. 103-103　2016/12/02　Research paper (scientific journal)

Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.

Tarusawa E, Sanbo M, Okayama A, Miyashita T, Kitsukawa T, Hirayama T, Hirabayashi T, Hasegawa S, Kaneko R, Toyoda S, Kobayashi T, Kato-Itoh M, Nakauchi H, Hirabayashi M, Yagi T, Yoshimura Y

BMC Biology　Vol. 14　No. 1　p. 103.-103　2016/12/02　Research paper (scientific journal)

Distinct and cooperative functions for the protocadherin-α, -β and -γ clusters in neuronal survival and axon targeting.

Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T

Frontiers in Molecular Neuroscience　Vol. 9:　p. 155.-155　2016/12　Research paper (scientific journal)

Transgenic rat model of childhood-onset dermatitis by overexpressing telomerase reverse transcriptase (TERT).

Ryosuke Kaneko, Atsuko Sato, Shun Hamada, Takeshi Yagi, Ichiro Ohsawa, Mamitaro Ohtsuki, Eiji Kobayashi, Masumi Hirabayashi, Takashi Murakami

Transgenic research　Vol. 25　No. 4　p. 413-24　2016/08　Research paper (scientific journal)

Transgenic rat model of childhood-onset dermatitis by overexpressing telomerase reverse transcriptase (TERT).

Kaneko R, Sato A, Hamada S, Yagi T, Ohsawa I, Ohtsuki M, Kobayashi E, Hirabayashi M, Murakami T

Transgenic Research　Vol. 25　No. 4　p. 413-424.　2016/08　Research paper (scientific journal)

Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.

Sonoko Hasegawa, Makiko Kumagai, Mitsue Hagihara, Hiroshi Nishimaru, Keizo Hirano, Ryosuke Kaneko, Atsushi Okayama, Teruyoshi Hirayama, Makoto Sanbo, Masumi Hirabayashi, Masahiko Watanabe, Takahiro Hirabayashi, Takeshi Yagi

Frontiers in molecular neuroscience　Vol. 9　p. 155-155　2016　Research paper (scientific journal)

ニューロンIDの可視化 クラスター型プロトカドヘリンの発現解析

金子 涼輔, 阿部 学, 高鶴 裕介, De Zeeuw Chris, 渡辺 雅彦, 崎村 建司, 柳川 右千夫, 八木 健

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [1LBA115]-[1LBA115]　2015/12

The transfer and transformation of collective network information in gene-matched networks.

Takashi Kitsukawa, Takeshi Yagi

Scientific reports　Vol. 5　p. 14984-14984　2015/10/09　Research paper (scientific journal)

Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.

Hilgo Bruining, Asuka Matsui, Asami Oguro-Ando, René S Kahn, Heleen M Van't Spijker, Guus Akkermans, Oliver Stiedl, Herman van Engeland, Bastijn Koopmans, Hein A van Lith, Hugo Oppelaar, Liselotte Tieland, Lourens J Nonkes, Takeshi Yagi, Ryosuke Kaneko, J Peter H Burbach, Nobuhiko Yamamoto, Martien J Kas

Biological psychiatry　Vol. 78　No. 7　p. 485-95　2015/10/01　Research paper (scientific journal)

The transfer and transformation of collective network information in gene-matched networks.

Kitsukawa T, Yagi T

Scientific Reports　Vol. 5　2015/09　Research paper (scientific journal)

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.

Arikuni Uchimura, Mayumi Higuchi, Yohei Minakuchi, Mizuki Ohno, Atsushi Toyoda, Asao Fujiyama, Ikuo Miura, Shigeharu Wakana, Jo Nishino, Takeshi Yagi

Genome research　Vol. 25　No. 8　p. 1125-34　2015/08　Research paper (scientific journal)

Population genetics and Brain evolution

Arikuni Uchimura, Takeshi Yagi

Vol. 33　No. 8　p. 909-911　2015/08

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.

Arikuni Uchimura, Mayumi Higuchi, Yohei Minakuchi, Mizuki Ohno, Atsushi Toyoda, Asao Fujiyama, Ikuo Miura, Shigeharu Wakana, Jo Nishino, Takeshi Yagi

Genome research　Vol. 25　No. 8　p. 1125-1134　2015/08　Research paper (scientific journal)

Impaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.

Reiko Meguro, Ryuichi Hishida, Hiroaki Tsukano, Kohei Yoshitake, Ryota Imamura, Manavu Tohmi, Takashi Kitsukawa, Takahiro Hirabayashi, Takeshi Yagi, Hirohide Takebayashi, Katsuei Shibuki

Journal of neurochemistry　Vol. 133　No. 1　p. 66-72　2015/04　Research paper (scientific journal)

Impaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.

Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukawa T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K

Journal of neurochemistry　Vol. 133　No. 1　p. 66-72　2015/04　Research paper (scientific journal)

Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development

Hilgo Bruining, Asuka Matsui, Asami Oguro-Ando, Rene S. Kahn, Heleen M. van't Spijker, Guus Akkermans, Oliver Stiedl, Herman van Engeland, Bastijn Koopmans, Hein A. van Lith, Hugo Oppelaar, Liselotte Tieland, Lourens J. Nonkes, Takeshi Yagi, Ryosuke Kaneko, J. Peter H. Burbach, Nobuhiko Yamamoto, Martien J. Kas

BIOLOGICAL PSYCHIATRY　Vol. 78　No. 7　p. 485-495　2015/02　Research paper (scientific journal)

Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-α cluster.

Kaneko R, Abe M, Hirabayashi T, Uchimura A, Sakimura K, Yanagawa Y, Yagi T

Scientific reports　Vol. 4　2014/09　Research paper (scientific journal)

Protocadherins in neurological diseases.

Hirabayashi T, Yagi T

Adv Neurobiol.　Vol. 8　p. 293-314　2014/08

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, Yagi T

Neuron　Vol. 82　No. 1　p. 94-108　2014/04　Research paper (scientific journal)

Protocadherins in neurological diseases.

Takahiro Hirabayashi, Takeshi Yagi

Advances in neurobiology　Vol. 8　p. 293-314　2014　Research paper (scientific journal)

Visual map shifts based on whisker-guided cues in the young mouse visual cortex.

Yoshitake K, Tsukano H, Tohmi M, Komagata S, Hishida R, Yagi T, Shibuki K

Cell Reports　Vol. 5　p. 1365-1374　2013/12　Research paper (scientific journal)

Genetic basis of neuronal individuality in the mammalian brain

Yagi T

Journal of Neurogenetics　Vol. 97　p. 97-105　2013/09

Clustered protocadherins and neuronal diversity.

Hirayama T, Yagi T

Progress in molecular biology and translational science　Vol. 116　p. 145-167　2013

Constitutively expressed Protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region

Sonoko Hasegawa, Takahiro Hirabayashi, Takahiko Kondo, Ken Inoue, Shigeyuki Esumi, Atsushi Okayama, Shun Hamada, Takeshi Yagi

Frontiers in Molecular Neuroscience　Vol. 5　2012/10　Research paper (scientific journal)

CTCF Is Required for Neural Development and Stochastic Expression of Clustered Pcdh Genes in Neurons

Teruyoshi Hirayama, Etsuko Tarusawa, Yumiko Yoshimura, Niels Galjart, Takeshi Yagi

CELL REPORTS　Vol. 2　No. 2　p. 345-357　2012/08　Research paper (scientific journal)

Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer

Haruyoshi Yamashita, Shanlin Chen, Seiji Komagata, Ryuichi Hishida, Takuji Iwasato, Shigeyoshi Itohara, Takeshi Yagi, Naoto Endo, Minoru Shibata, Katsuei Shibuki

PLoS ONE　Vol. 7　No. 4　2012/04　Research paper (scientific journal)

Molecular codes for neuronal individuality and cell assembly in the brain

Takeshi Yagi

Frontiers in Molecular Neuroscience　No. MARCH　p. 1-31　2012/04　Research paper (scientific journal)

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

Mako Yamamoto, Tomoko Matsuzaki, Rei Takahashi, Eijiro Adachi, Yasuhiro Maeda, Sachiyo Yamaguchi, Hitoshi Kitayama, Michiko Echizenya, Yoko Morioka, David B. Alexander, Takeshi Yagi, Shigeyoshi Itohara, Takashi Nakamura, Haruhiko Akiyama, Makoto Noda

Biology Open　Vol. 1　No. 5　p. 458-466　2012/03　Research paper (scientific journal)

Mutant mice for CNR/protocadherin genes

Katori, S, Yagi, T

2011/11

Identification of the cluster control region for the Protocadherin-b genes located beyond the Protocadherin-g cluster.

Yokota S, Hirayama T, Hirano K, Kaneko R, Toyoda S, Kawamura Y, Hirabayashi M, Hirabayashi T, Yagi T

Journal of Biological Chemistry　Vol. 286　No. 36　p. 31885-31895.　2011/09　Research paper (scientific journal)

A novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in mice.

Kitsukawa T, Nagata M, Yanagihara D, Tomioka R, Utsumi H, Kubota Y, Yagi T, Graybiel AM, Yamamori T

Journal of Neurophysiology　2011/07　Research paper (scientific journal)

Selective ablation of histamine H1 receptor-expressing neurons in the paraventricular nucleus of the hypothalamus to study their role in the regulation of food intake

Shuhei Horio, Shuji Kitaike, Tetsuya Shiuchi, Yasuhiko Minokoshi, Makoto Sanbo, Takahiro Hirabayashi, Takeshi Yagi, Nobuyuki Kai, Kazuto Kobayashi, Takashi Ueyama, Hiroyuki Fukui

NEUROSCIENCE RESEARCH　Vol. 71　p. E162-E162　2011

Establishment of rat embryonic stem cell lines that can participate Into germline chimerae at high efficiency.

Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H

Molecular Reproduction and Development　Vol. 77　No. 2　2009/11　Research paper (scientific journal)

Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Protocadherin-alpha cluster.

Noguchi Y, Hirabayashi T, Katori S, Kawamura Y, Sanbo M, Hirabayashi M, Kiyonari H, Nakao K, Uchimura A, Yagi T

Journal of Biological Chemistry　Vol. 284　No. 46　p. 32002-32014　2009/11　Research paper (scientific journal)

The chromosomal constitution of postmitotic neurons, assessed by neuronal nuclear transfer into oocytes and in ES cell lines derived from them.

Osada T, Kakazu N, Watanabe M, Yamane H, Yagi T

Cytogenetic Genome Research　2009/07　Research paper (scientific journal)

Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning.

Yoko Yamagata, Shizuka Kobayashi, Tatsuya Umeda, Akihiro Inoue, Hiroyuki Sakagami, Masahiro Fukaya, Masahiko Watanabe, Nobuhiko Hatanaka, Masako Totsuka, Takeshi Yagi, Kunihiko Obata, Keiji Imoto, Yuchio Yanagawa, Toshiya Manabe, Shigeo Okabe

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 29　No. 23　p. 7607-18　2009/06/10　Research paper (scientific journal)

Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia.

Hattori K, Fukuzako H, Hashiguchi T, Hamada S, Murata Y, Isosaka T, Yuasa S, Yagi T

Psychiatry Research　Vol. 168　No. 2　p. 119-128　2009/06　Research paper (scientific journal)

Protocadherin-a family is required for serotonergic projections to appropriately innervate target brain areas.

Katori S, Hamada S, Noguchi Y, Fukuda E, Yamamoto T, Yamamoto H, Hasegawa S, Yagi T

The Journal of Neuroscience　Vol. 29　No. 29　p. 9137-9147　2009/05　Research paper (scientific journal)

Kinase-dead knock-in mouse revealed an essential role of CaMKIIa kinase activity in dendritic spine enlargement, LTP and learning.

Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S

The Journal of Neuroscience　2009/04　Research paper (scientific journal)

Kinase activity of CaMKII alpha is essential for structural, functional and behavioral expression of synaptic memory

Yamagata Yoko, Kobayashi Shizuka, Umeda Tatsuya, Inoue Akihiro, Sakagami Hiroyuki, Fukaya Masahiro, Watanabe Masahiko, Hatanaka Nobuhiko, Totsuka Masako, Yagi Takeshi, Obata Kunihiko, Imoto Keiji, Yanagawa Yuchio, Manabe Toshiya, Okabe Shigeo

NEUROSCIENCE RESEARCH　Vol. 65　p. S144-S144　2009

Rapid identification of virus-carrying mosquitoes using reverse transcription-loop-mediated isothermal amplification.

Perera N, Aonuma H, Yoshimura A, Teramoto T, Iseki H, Nelson B, Igarashi I, Yagi T, Fukumoto S, Kanuka H

Journal of Virological Methods　2009/01　Research paper (scientific journal)

遺伝子からみた脳の進化のシナリオ

八木 健

生体の科学　2009/01

Expressional levels of Protocadherin-a transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions.

Kaneko R, Kawaguchi M, Toyama T, Yagi T

Gene　Vol. 430　No. 1-2　p. 86-94　2009/01　Research paper (scientific journal)

DNA polymerase delta is required for early mammalian embryogenesis.

Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M, Yagi T

PLoS ONE　Vol. 4　No. 1　2009/01　Research paper (scientific journal)

NORADRENERGIC EXCITATION OF A SUBPOPULATION OF GABAergic CELLS IN THE BASOLATERAL AMYGDALA VIA BOTH ACTIVATION OF NONSELECTIVE CATIONIC CONDUCTANCE AND SUPPRESSION OF RESTING K+ CONDUCTANCE: A STUDY USING GLUTAMATE DECARBOXYLASE 67-GREEN FLUORESCENT PROTEIN KNOCK-IN MICE

K. Kaneko, N. Tamamaki, H. Owada, T. Kakizaki, N. Kume, M. Totsuka, T. Yamamoto, H. Yawo, T. Yagi, K. Obata, Y. Yanagawa

NEUROSCIENCE　Vol. 157　No. 4　p. 781-797　2008/12　Research paper (scientific journal)

Rapid identification of Plasmodium-carrying mosquitoes using loop-mediated isothermal amplification.

Aonuma H, Suzuki M, Iseki H, Perera N, Nelson B, Igarashi I, Yagi T, Kanuka H, Fukumoto S

Biochemical and Biophysical Research Communications　Vol. 376　No. 4　p. 671-6　2008/11　Research paper (scientific journal)

Down-regulation of protocadherin-a A isoforms in mice changes contextual fear conditioning and spatial working memory.

Fukuda E, Hamada S, Hasegawa S, Katori S, Sanbo M, Miyakawa T, Yamamoto T, Yamamoto H, Hirabayashi T, Yagi T

European Journal of Neuroscience　Vol. 28　No. 7　p. 1362-1376　2008/09　Research paper (scientific journal)

Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contexual conditioning.

Isosaka T, Hattori K, Kida S, Kohno T, Nakazawa T, Yamamoto T, Yagi T, Yuasa S

European Journal of Neuroscience　Vol. 28　p. 973-981　2008/08　Research paper (scientific journal)

Clustered protocadherin family.

Yagi T

Development and Growth Differentiation　Vol. 50　p. S131-S140　2008/06　Research paper (scientific journal)

クラスター型プロトカドヘリンファミリーー多様性創出機構とその機能解明に向けて

平山晃斉, 長谷川園子, 八木 健

蛋白質 核酸 酵素　2008/04

The protocadherin-a family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse.

Hasegawa S, Hamada S, Kumode Y, Esumi S, Katori S, Fukuda E, Uchiyama Y, Hirabayashi T, Mombearts P, Yagi T

Molecular and Cellular Neuroscience　Vol. 38　No. 1　p. 66-79　2008/04　Research paper (scientific journal)

[Clustered protocadherin family].

Hirayama T, Hasegawa S, Yagi T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 53　No. 4 Suppl　p. 358-364　2008/03

Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster.

Kawaguchi M, Toyama T, Kaneko R, Hirayama T, Kawamura Y, Yagi T

Journal of Biological Chemistry　Vol. 283　No. 18　p. 12064-12075　2008/03　Research paper (scientific journal)

Protocadherin family: diversity, structure, and function.

Morishita, H, Yagi, T

Curr Opin Cell Biol　Vol. 19　No. 5　p. 584-592　2007/10　Research paper (scientific journal)

Mouse liaison for integrative brain research

Aiba, A, Inokuchi, K, Ishida, Y, Itohara, S, Kobayashi, K, Masu, M, Mishina, M, Miyakawa, T, Mori, H, Nakao, K, Obata, Y, Sakimura, K, Shiroishi, T, Wada, K, Yagi, T

Neurosci Res　Vol. 58　No. 2　p. 103-104　2007/06　Research paper (scientific journal)

Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.

Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A, Watanabe K, Akita M, Yagi T, Tanaka K, Asou H

J Neurosci Res.　2007/02　Research paper (scientific journal)

Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers.

Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chedotal A, Mitchell KJ, Manabe T, Fujisawa H

Neuron　Vol. 53　No. 4　p. 535-47　2007/02　Research paper (scientific journal)

Split single cell RT-PCR analysis of Purkinje cells.

Esumi S, Kaneko R, Kawamura Y, Yagi T

Nature Protocols　Vol. 1　No. 4　p. 2143-2151　2006/12　Research paper (scientific journal)

Structure of the CNR/Protocadherin-alpha first cadherin domain reveals diversity across cadherin families.

Morishita H, Umitsu M, Murata Y, Shibata N, Udaka K, Higuchi Y, Akutsu H, Yamaguchi T, Yagi T, Ikegami T

J Biol Chem　Vol. 281　No. 44　p. 33650-33663　2006/11　Research paper (scientific journal)

Neuronal genomics using mouse cloning with the single neuronal nucleus.

Osada T, Yagi T

Current Genomics　2006/10　Research paper (scientific journal)

カドヘリンの分子進化

八木 健

生体の科学　2006/10

Allelic gene regulation of protocadherin-α and -γ clusters involving both monoallelic and biallelic expression in single Purkinje cells.

Kaneko R, Kato H, Kawamura Y, Esumi S, Hirayama T, Hirabayashi T, Yagi T

J Biol Chem　Vol. 281　No. 41　p. 30551-30560　2006/10　Research paper (scientific journal)

Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.

Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M

J Neurochem　2006/09　Research paper (scientific journal)

Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses.

Terawaki K, Yokomizo T, Nagase T, Toda A, Taniguchi M, Hashizume K, Yagi T, Shimizu T

J Immunol　2006/08　Research paper (scientific journal)

Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.

Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Li Xu, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S

Eur J Neurosci.　2006/08　Research paper (scientific journal)

Fyn-induced phosphorylation of beta-adducin at tyrosine 489 and its role in their subcellular localization.

Gotoh H, Okumura N, Yagi T, Okumura A, Shima T, Nagai K

Biochem Biophys Res Commun.　Vol. 346　No. 2　p. 600-605　2006/08　Research paper (scientific journal)

Protocadherins: classification, structures and functions

Shun Hamada, Takeshi Yagi

SEIKAGAKU　Vol. 78　No. 7　p. 662-671　2006/07　Research paper (scientific journal)

ミエリン化による神経軸索の成熟化と膜蛋白質の局在変化

森下博文, 八木健

生体の科学　2006/06

The role and expression of the protocadherin-alpha clusters in the CNS.

Hirayama T, Yagi T

Curr Opin Neurobiol.　Vol. 16　No. 3　p. 336-342　2006/06　Research paper (scientific journal)

Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.

Morita A, Yamashita N, Sasaki Y, Uchida Y, Nakajima O, Nakamura F, Yagi T, Taniguchi M, Usui H, Katoh-Semba R, Takei K, Goshima Y

J Neurosci　Vol. 26　p. 2971-2980　2006/04　Research paper (scientific journal)

行動を支配する遺伝子は環境しだい

八木健

脳と心のしくみ、ニュートン　2006/04

細胞内シグナル伝達系ー高次脳機能の制御

湯浅茂樹, 服部功太郎, 甲斐信行, 中平英子, 伊早坂智子, 八木健

先進脳神経科学　2006/03

Fyn is required for haloperidol-induced catalepsy in mice.

Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S

J Biol Chem.　Vol. 281　No. 11　p. 7129-7135　2006/03　Research paper (scientific journal)

Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis.

Kai N, Iwase K, Imai K, Nakahira E, Soma M, Ohtsuka S, Yagi T, Kobayashi K, Koga H, Takiguchi M, Yuasa S

Brain Res.　Vol. 1073-1074　p. 60-70　2006/02　Research paper (scientific journal)

Predominant expression of rTERTb, an inactive TERT variant, in the adult rat brain.

Kaneko R, Esumi S, Yagi T, Hirabayashi T

Protein Pept Lett.　Vol. 13　p. 59-65　2006/02　Research paper (scientific journal)

発達障害仮説における大脳皮質形成関連遺伝子の意義

服部功太郎, 伊早坂智子, 湯浅茂樹, 八木健

脳と精神の医学　Vol. 17　No. 1　p. 65-72　2006/01

Evaluation of somatic alterations of Pcdh-αtranscripts in the brain by cDNA analysis without PCR.

Hirayama T, Sasaki A, Yagi T

Genes to Cells　Vol. 11　No. 1　p. 95-97　2006/01　Research paper (scientific journal)

NMDA-receptor proteins are upregulated in the hippocampus of post-natal heterozygous reeler mice.

Isosaka T, Hattori K, Yagi T

Brain Res.　Vol. 1073　p. 11-19　2006/01　Research paper (scientific journal)

Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice.

Osada T, Tamamaki N, Song S-Y, Kakazu N, Yamazaki Y, Makino H, Sasaki A, Hirayama T, Hamada S, Nave K-A, Yanagimachi R, Yagi T

J Neurosci　Vol. 25　No. 37　p. 8368-8374　2005/09　Research paper (scientific journal)

Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells.

Ohsawa S, Hamada S, Kakinuma Y, Yagi T, Miura M

J Neurosci Res　2005/05　Research paper (scientific journal)

Fc{varepsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.

Nishida K, Yamasaki S, Ito Y, Kabu K, Hattori K, Tezuka T, Nishizumi H, Kitamura D, Goitsuka R, Geha RS, Yamamoto T, Yagi T, Hirano T

J Cell Biol　2005/05　Research paper (scientific journal)

Molecular Evolution of Cadherin-Related Neuronal Receptor/Protocadherinα (CNR/Pcdhα) Gene Cluster in Mus musculus Subspecies

Taguchi Y, Koide T, Shiroishi T, Yagi T

Molecular Biology and Evolution　Vol. 22　No. 6　p. 1433-1443　2005/04　Research paper (scientific journal)

Mouse embryos and chimera cloned from neural cells in the postnatal cerebral cortex

Hatsune Makino, Yukiko Yamazaki, Takahiro Hirabayashi, Ryosuke Kaneko, Shun Hamada, Yoshimi Kawamura, Tomoharu Osada, Ryuzo Yanagimachi, Takeshi Yagi

Cloning and Stem Cells　Vol. 7　No. 1　p. 45-61　2005/03　Research paper (scientific journal)

Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses.

Terawaki K, Yokomizo T, Nagase T, Toda A, Taniguchi M, Hashizume K, Yagi T, Shimizu T

J Immunol　Vol. 175　p. 4217-4225　2005/02　Research paper (scientific journal)

神経系における多様化膜分子群：CNR/プロトカドヘリンファミリー

村田陽二, 八木健

神経研究の進歩　Vol. 49　No. 1　p. 115-127　2005/02

Fruit fly as a model of insect vector

Aonuma H, Yagi T, Miura M, Schneider D, Kanuka H

Medical Entomology and Zoology　Vol. 56　p. 64-64　2005

Ｉｎａｂａラット：疾患発症時期がヒトと類似しているアトピー性皮膚炎モデルトランスジェニックラット

金子 涼輔, 加藤 めぐみ, 石川 綾子, 平林 敬浩, 濱田 俊, 八木 健, 平林 真澄

日本疾患モデル学会記録　Vol. 21　p. 22-26　2005

Letter to the Editor: 1H, 13C and 15N resonance assignments of the first cadherin domain of cadherin-related neuronal receptor (CNR)/protocadherin α [3]

Umitsu M, Morishita H, Murata Y, Udaka K, Akutsu H, Yagi T, Ikegami T

Journal of Biomolecular NMR　Vol. 31　No. 4　p. 365-366　2005

Monoallelic yet combinatorial expression of variable exons of the CNR/Protocadherin-a gene cluster in single neurons

Esumi S, Kakazu N, Taguchi Y, Hirayama T, Sasaki A, Hirabayashi T, Koide T, Kitsukawa T, Hamada S, Yagi T

Nature Genet　Vol. 37　No. 2　p. 171-176　2005/01　Research paper (scientific journal)

Plexin-A4 Mediates Axon-Repulsive Activities of Both Secreted and Transmembrane Semphorins and Play Roles in Nerve Fiber Guidance

Sudo F, Ito K, Uemura M, Shimizu M, Shinkawa Y, Sanbo M, Shinoda T, Tsuboi M, Takashima S, Yagi T, Fujisawa H

J Neurosci.　Vol. 25　No. 14　p. 3628-3637　2004/12　Research paper (scientific journal)

CNR/Pcdh alpha family in subplate neurons, and developing cortical connectivity

H Morishita, Y Murata, S Esumi, S Hamada, T Yagi

NEUROREPORT　Vol. 15　No. 17　p. 2595-2599　2004/12　Research paper (scientific journal)

Myelination triggers local loss of axonal CNR/protocadherin alpha family protein expression

H Morishita, M Kawaguchi, Y Murata, C Seiwa, S Hamada, H Asou, T Yagi

EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 20　No. 11　p. 2843-2847　2004/12　Research paper (scientific journal)

Factors affecting production of transgenic rats by ICSI-mediated DNA transfer: Effects of sonication and freeze-thawing of spermatozoa, rat strains for sperm and oocyte donors, and different constructs of exogenous DNA

Hirabayashi M, Kato M, Ishikawa A, Kaneko R, Yagi T, Hochi S

Mol Reprod Dev　Vol. 70　No. 4　p. 422-428.　2004/11　Research paper (scientific journal)

Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice

K Hamaguchi-Hamada, S Hamada, T Yagi

MOLECULAR BRAIN RESEARCH　Vol. 130　No. 1-2　p. 187-190　2004/11　Research paper (scientific journal)

Production of transgenic rats by ooplasmic injection of spermatogenic cells exposed to exogenous DNA: A preliminary study.

Kato M, Ishikawa A, Kaneko R, Yagi T, Hochi S, Hirabayashi M

Molecular Reproduction and Development　Vol. 69　No. 2　p. 153-158.　2004/10　Research paper (scientific journal)

Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme

Kettunen P, Loes, S, Furmanek T, Field K, Kvinnsland IH, Behar O, Yagi T, Fujisawa H, Vainio S, Taguchi M, Luukko K

Development　2004/09　Research paper (scientific journal)

Reelinと統合失調症

服部功太郎, 伊早坂智子, 八木健

Schizophrenia Fronteir　2004/08

Negative and positive effects of an IAP-LTR on nearby Pcda alpha gene expression in the central nervous system and neuroblastoma cell lines

H Sugino, T Toyama, Y Taguchi, S Esumi, M Miyazaki, T Yagi

GENE　Vol. 337　p. 91-103　2004/08　Research paper (scientific journal)

Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E

CX Li, Y Sasaki, K Takei, H Yamamoto, M Shouji, Y Sugiyama, T Kawakami, F Nakamura, T Yagi, T Ohshima, Y Goshima

JOURNAL OF NEUROSCIENCE　Vol. 24　No. 27　p. 6161-6170　2004/07　Research paper (scientific journal)

A Novel Function of Neuronal PAS Domain Protein 1 (NPAS1) in Erythropoietin Expression in Neuronal Cells

Ohsawa S, Hamada S, Kakinuma Y, Yagi T, Miura M

J. Neurosci. Res.　2004/07　Research paper (scientific journal)

Erratum: Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with β1 integrin mediated through the RGD site of CNR1 (Experimental Cell Research (2004) 294 (494-508) DOI: 10.1016/j.yexcr.2003.11. 019)

Tetsuji Mutoh, Shun Hamada, Kouji Senzaki, Yoji Murata, Takeshi Yagi

Experimental Cell Research　Vol. 297　No. 1　2004/07/01　Research paper (scientific journal)

Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-α and –β gene clusters

Miki R, Hattori K, Taguchi Y, Tada M, Isosaka T, Hidaka Y, Hirabayashi T, Hashimoto R, Fukuzako H, Yagi T

GENE　Vol. 349　p. 1-14　2004/07　Research paper (scientific journal)

Myelination triggers down-regulation of axonal CNR/Protocadherinα family expression

Morishita H, Murata Y, Esumi S, Hamada S, Yagi T

Eur. J, Neurosci.　2004/06　Research paper (scientific journal)

Auditory-conditioned-fear-dependent c-Fos expression is altered in the emotion-related brain structures of Fyn-deficient mice

Kubota O, Hattor K, Hashimoto K, Yagi T, Sato T, Iyo M, Yuasa S

Mol. Brain Res.　Vol. 130　p. 149-160　2004/06　Research paper (scientific journal)

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha

Y Murata, S Hamada, H Morishita, T Mutoh, T Yagi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 47　p. 49508-49516　2004/06　Research paper (scientific journal)

NMDA receptor GluRepsilon/NR2 subunits are essentil for postsynaptic localization and protein stability of GluRzeta 1/NR1 subunit

Abe M, Fukuya M, Yagi T, Mishina M, Watanabe M, Sakimura K

J. Neuroscei.　2004/05　Research paper (scientific journal)

Genomic organization and transcripts of the zebrafish Protocadherin genes

Tada T, Senzaki K, Tai Y, Morishita H, Tanaka Y, Murata Y, Ishii Y, Asakawa S, Shimizu N, Sugino H, Yagi T

Gene　Vol. 340　No. 2　p. 197-211　2004/05　Research paper (scientific journal)

Defective neocortical development in Fyn-tyrosine-kinase-deficient mice

Yuasa S, Hattori K, Yagi T

Neuro Report　Vol. 15　No. 5　p. 819-822　2004/04　Research paper (scientific journal)

Distinct genomic sequence of the CNR/Pcdhαgenes in chiken

Sugino H, Yanase H, Hamada S, Kurokawa K, Asakawa S, Shimizu N, Yagi T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 316　No. 2　p. 437-445　2004/04　Research paper (scientific journal)

Cadherin-related Neuronal Receptor 1(CNR1) has cell-adhesion activity with β1 integrin mediated through the RGD site of CNR1

Mutoh T, Hamada S, Yagi T

EXPERIMENTAL CELL RESEARCH　Vol. 294　No. 2　p. 494-508　2004/04　Research paper (scientific journal)

Genomic sequence and organization of the family of CNR /Pcdhα genes in Rat

Yanase H, Sugino H, Yagi T

GENOMICS　Vol. 83　No. 4　p. 717-726　2004/04　Research paper (scientific journal)

Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice

Hamaguchi-Hamada K, Sanbo C, Hamada S, Yagi T

Neurosci. Res.　Vol. 48　No. 3　p. 259-267　2004/03　Research paper (scientific journal)

Intron-less processed cadherin-related neuronal receptor (CNR/Pcdha) genes in the central nervous system

Sugino H, Miyazaki M, Yagi T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 313　No. 3　p. 775-783　2004/01　Research paper (scientific journal)

Role of Fyn tyrosine kinase in ethanol consumption by mice.

Cowen MS, Schumann G, Yagi T, Spanagel R

Alcohol Clin Exp Res.　2003/08　Research paper (scientific journal)

Signaling via Immunoglobulin Fc Receptors Induces Oligodendrocyte Precursor Cell Differentiation

Nakahara J, Tan-Takeuchi K, Seiwa C, Gotoh M, Kaifu T, Ujike A, Inui M, Yagi T, Ogawa M, Aiso S, Takai T, Asou H

Developmental Cell　Vol. 4　No. 6　p. 841-52　2003/06　Research paper (scientific journal)

Mouse circadian rhythm before the Kobe earthquake in 1995.

Yokoi S, Ikeya M, Yagi T, Nagai K

Bioelectromagnetics　Vol. 24　No. 4　p. 289-291　2003/03　Research paper (scientific journal)

Cadherin-related Neuronal Receptors in Incisor Development

Fukumoto E, Sakai H, Fukumoto S, Yagi T, Takagi O, Kato Y

J Dent Res.　Vol. 82　No. 1　p. 17-22　2003/02　Research paper (scientific journal)

Distorted Odor Maps in the Olfactory Bulb of Semaphorin 3A-Deficient Mice

Taniguchi M, Nagao H, Takahashi Y, Yamaguchi M, Mitsui S, Yagi T, Mori K, Shimizu T

The Journal of Neuroscience　Vol. 23　p. 1390-1397　2003/02　Research paper (scientific journal)

Differential non-target-derived repulsive signals play a critical role in shaping initial axonal growth of dorsal root ganglion neurons.

Masuda T, Tsuji H, Taniguchi M, Yagi T, Tessier-Lavigne M, Fujisawa H, Okado N, Shiga T

Developmental Biology　Vol. 254　p. 289-302　2003/02　Research paper (scientific journal)

神経系における多様化膜分子群：遺伝子クラスターを形成するCNR/プロトカドヘリンファミリー

濱田俊, 八木健

比較生理生化学　2003/01

Diversity of the cadherin-related neuronal receptor/protocadherin family and possible DNA rearrangement in the brain

T Yagi

GENES TO CELLS　Vol. 8　No. 1　p. 1-8　2003/01

Fyn is essential for tyrosinase phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minaki Y, Kato A, Tani-ichi S, Hamaoka T, Kosugi A

J Immunol,169,2813-2817　Vol. 169　No. 6　p. 2813-2817　2002/10　Research paper (scientific journal)

Fyn and Cdk5 Mediate Semaphorin-3A Signaling, Which is Involved in Regulation of Dendrite Orientation in Cerebral Cortex

Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y

2002/08　Research paper (scientific journal)

Fyn Tyrosinase in Sertoki Cells Is Involved in Mouse Spermatogenesis

Maekawa M, Toyama Y, Yasda M, Yagi T, Yuasa S

Biol. Reprod.　Vol. 66　p. 211-221　2002/08　Research paper (scientific journal)

Wengen, a member of the Drosophila TNF receptor superfamily, is required for Eiger signaling

Kanda H, Igaki T, Kanuka H, Yagi T, Miura M

J. Biol. Chem.　Vol. 277　p. 28372-28375　2002/08　Research paper (scientific journal)

脳機能形成メカニズムに関与する多様化した接着分子群-シナプスに存在する接着分子の多様性と分子間相互作用について

武藤哲司, 八木健

脳の科学　2002/07

脳機能形成メカニズムに関与する多様化した接着分子郡-シナプスに存在する接着分子の多様性と分子間相互作用について-

武藤哲司, 八木 健

脳の科学 24:747-754　2002/06

生命の知恵 多様性をもたらす無駄

八木 健

科学 Vol.72 No.3 Mar. 2002 323-329　2002/06

Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system.

Kawasaki T, Bekku Y, Suto F, Kitsukawa T, Taniguchi M, Nagats I, Nagatsu T, Itoh K, Yagi T, Fujisawa H

Development　Vol. 129　p. 671-680　2002/02　Research paper (scientific journal)

Light-potentiation of acoustic startle response (ASR) and monoamine efflux related to fearfulness in Fyn-deficient mice.

Hironaka N, Yagi T, Niki H

2002/01　Research paper (scientific journal)

Adult murine neurons: their chromatine and chromosome changes and failure to support embryonic development as revealed by nuclear transfer

Osada T, Kusakabe H, Akutsu H, Yagi T, Yanagimachi R

Cytogenetic and Genome Research　Vol. 97　No. 1-2　p. 7-12　2002/01　Research paper (scientific journal)

Diversity of the cadherin-related neuronal receptor family in the nervous system

Yagi T, Tada M, Tanaka Y, Senzaki K, Hirayama T, Hamada S, Sugino H

International Congress Series　Vol. 1246　p. 127-136　2002

Interaction of the SH2 domain of Fyn with a cytoskeletal protein, β-aducin.

Shima T, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K

Journal of Biological Chemistry　Vol. 276　No. 45　p. 42233-42240　2001/11　Research paper (scientific journal)

セマフォリン3A情報伝達はFyn-Cdk5リン酸化カスケードを介する

佐々木 幸生, Cheng Chi, 内田 穣, 大島 登志男, 八木 健, 谷口 雅彦, 中山 孝, 工藤 佳久, 大野 重昭, 中村 史雄

神経化学　Vol. 40　No. 2-3　p. 269-269　2001/09

Guidance of glial precursor cell migration by secreted cues in the developing optic nerve.

Sugimoto Y, Taniguchi M, Yagi T, Akagi Y, Nojyo Y, Tamamaki N

2001/09　Research paper (scientific journal)

セマフォリン3A情報伝達におけるFyn-Cdk5リン酸化カスケードの役割

佐々木 幸生, Cheng Chi, 内田 穣, 大島 登志男, 八木 健, 谷口 雅彦, 中山 孝, 工藤 佳久, 大野 重昭, 中村 史雄

生化学　Vol. 73　No. 8　p. 918-918　2001/08

Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression.

Miyakawa T, Yagi T, Takao K, Niki H

Behavioural brain research　Vol. 122　p. 51-56　2001/07　Research paper (scientific journal)

脳の獲得的性質を支える分子メカニズムの探索 CNR／プロトカドヘリンファミリーの遺伝子構造と機能

平山晃斉, 杉野英彦, 八木 健

蛋白質 核酸 酵素 Vol.46 No.6(2001) 698-705　2001/06

脳機能形成メカニズムにかかわる多様化膜分子群

八木 健

ポストシーケンスのゲノム科学④ ゲノムから固体へ 生命システムの理解に向けて 148－163　2001/06

N-Methyl-d-aspartate-induced c-Fos expression is enhanced in the forebrain structures related to emotion in Fyn-deficient mice.

Hattori K, Yagi T, Maekawa M, Sato T, Yuasa S

Brain Res.　Vol. 905　p. 188-198　2001/06　Research paper (scientific journal)

Transgenic and gene "knockout" models in alcohol research.

Hoffmn PL, Yagi T, Tabakoff B, Phillips TJ, Kono H, Messing RO, Choi D-S

2001/05　Research paper (scientific journal)

Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8.

Takei Y, Hamada S, Senzaki K, Mutoh T, Sugino H, Yagi T

GENOMICS　Vol. 72　No. 3　p. 321-330　2001/03　Research paper (scientific journal)

Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia.

Nakahara J, Tan-Takeuchi K, Seiwa C, Yagi T, Aiso S, Kawamura K, Asou H

2001/02　Research paper (scientific journal)

Somatic mutations of synaptic cadherin (CNR family) transcripts in the nervous system.

Hirayama T, Sugino H, Yagi T

Genes Cells　Vol. 6　p. 151-164　2001/02　Research paper (scientific journal)

Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule.

Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, Sanbo M, Yagi T, Inoue Y, Nabeshima T, Mori H, Mishina M

2001/01　Research paper (scientific journal)

Signaling cascade of CNR cadherins (Reelin receptors) in the mammalian brain

Yagi.T

2001/01　Research paper (scientific journal)

Mouse embryonic stem (ES) cell lines established from neuronal cell-derived cloned blastocysts.

Kawase E, Yamazaki Y, Yagi T, Yanagimachi R, Pedersen R.A

Genesis　Vol. 28　p. 156-163　2000/11　Research paper (scientific journal)

シナプス形成とカドヘリンスーパーファミリー－シナプス形成の分子基盤か？-

濱田俊, 八木健

脳２１　2000/10

Involvement of complexin II in synaptic plasticity in the CA1 region of the hippocampus: the use of complexin II-lacking mice.

Huang G-Z, Ujihara H, Takahashi S, Kaba H, Yagi T, Inoue S

The Japanese Journal of Pharmacology　Vol. 84　No. 2　p. 179-187　2000/10　Research paper (scientific journal)

Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung.

Ito T, Kagoshima M, Sasaki Y, Li C, Udaka N, Kitukawa T, Fujisawa H, Taniguchi M, Yagi T, Kitamura H, Goshima Y

2000/10　Research paper (scientific journal)

マウス大脳皮質層構造形成機構における新たな分子メカニズムの解明－CNRファミリーはReelinの多重受容体である－

先崎浩次, 小川正晴, 八木 健

実験医学 Vol.18 No.6(4月号）2000　2000/06

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

Yagi T, Takeichi M

Genes Dev　Vol. 14　p. 1169-1180　2000/05　Research paper (scientific journal)

Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system.

Seiwa C, Sugiyama I, Yagi T, Iguchi T, Asou H

Vol. 37　No. 1　p. 21-31　2000/03　Research paper (scientific journal)

In vivo gene transfer to mouse spermatogenic cells using green fluorescent protein as a marker.

Yamazaki Y, Yagi T, Ozaki T, Imoto K

J. Exp. Zool.　Vol. 286　p. 212-218　2000/02　Research paper (scientific journal)

Dynamic characteristics and adaptability of reflex eye movements of Fyn kinase-deficient mice.

Kitazawa H, Katoh A, Yagi T, Nagao S

2000/02　Research paper (scientific journal)

Impairment of conditioned avoidance response in Fyn-kinase deficient mice.

Zhen-tong M, Xiao-feng M, Yagi T, Yamagishi S

2000/01　Research paper (scientific journal)

Proteins of the CNR family are multiple receptors for Reelin.

Senzaki K, Ogawa M, Yagi T

Cell　Vol. 99　p. 635-647　1999/12　Research paper (scientific journal)

A requirement for neuropilin-1 in embryonic vessel formation.

Kawasaki T, Kitsukawa T, Bekku Y, Matsuda Y, Sanbo M, Yagi T, Fujisawa H

Development　Vol. 126　p. 4895-4902　1999/12　Research paper (scientific journal)

Reduced hippocampal LTP in mice lacking a presynaptic protein: complexin II.

Takahashi S, Ujihara H, Huang G-Z, Yagyu K, Sanbo M, Kaba H, Yagi T

Eur J Neurosci　Vol. 11　p. 2539-2366　1999/07　Research paper (scientific journal)

免疫系多様化分子郡と類似性を示す中枢神経系の新規カドヘリン（CNR)ファミリー

八木 健

脳の科学，21：923-936，1999　1999/06

Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker.

Yanagawa Y, Kobayashi T, Ohnishi M, Kobayashi T, Tamura S, Tsuzuki T, Sanbo M, Yagi T, Tashiro F, Miyazaki J

Transgenic Res.　Vol. 8　p. 215-221　1999/06　Research paper (scientific journal)

Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and an ethanol sensitivity.

Yagi T

Biochem. Pharmacol.　Vol. 57　p. 845-850　1999/04　Research paper (scientific journal)

テレンセファリン遺伝子にCreリコンビナーゼ遺伝子を挿入した変異マウスの作製と解析

中村 和裕, 森 寿, 城山 優治, 八木 健, 真鍋 俊也, 高橋 智幸, 渡辺 雅彦, 市川 量一, 井上 芳郎, 三品 昌美

神経化学　Vol. 37　No. 3　p. 555-555　1998/09

Role of the carboxy-terminal region of the GluRε2 subunit in synaptic localization of the NMDA receptor channel.

Mori H, Manabe T, Watanabe M, Satoh Y, Suzuki N, Toki S, Nakamura K, Yagi T, Kushiya E, Takahashi T, Inoue Y, Sakimura K, Mishina M

1998/09　Research paper (scientific journal)

脳の機能と遺伝情報

八木 健

脳の科学，20：555-558，1998　1998/06

Efficient production of Cre-mediated site-directed Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells.

Taniguchi M, Sanbo M, Watanabe S, Naruse I, Mishina M, Yagi T

1998/01　Research paper (scientific journal)

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

Kohmura N, Senzaki K, Hamada S, Kai N, Yasuda R, Watanabe M, Ishii H, Yasuda M, Mishina M, Yagi T

Neuron　Vol. 20　p. 1137-1151　1998/01　Research paper (scientific journal)

Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase deficient mice.

Kitazawa H, Yagi T, Miyakawa T, Niki H, Kawai N

Journal of neurophysiology　Vol. 79　p. 137-142　1998/01　Research paper (scientific journal)

Neuropilin-Semaphorin III/D-Mediated Chemonepulsive Signals play a crucial Role in Peripheral Nerve Projection in Mice.

Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H

Neuron　Vol. 19　p. 995-1005　1997/11　Research paper (scientific journal)

Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA-receptor function.

Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, Niki H

Science (New York, N.Y.)　Vol. 278　No. 5338　p. 698-701　1997/10　Research paper (scientific journal)

Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.

Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T

Neuron　Vol. 19　p. 519-519　1997/09　Research paper (scientific journal)

Suppression of autoimmune disease and of massive lymphadenopathy in MR/MRL-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn)1.

Takahashi T, Yagi T, Kakinuma S, Kurokawa A, Okada T, Takatsu K, Aizawa S, Katagiri T

J. Immunol.　Vol. 159　p. 2532-2532　1997/09　Research paper (scientific journal)

脳の進化をもたらした遺伝子の探索―情動形成に関わる分子メカニズムによる研究―

八木 健

細胞工学 Vol.16 No.8 1140-1149　1997/06

Fyn欠損マウスの脳形成・機能異常の解析

八木 健

神経研究の進歩 第41巻 第5号 1997年10月　1997/06

マウス固体における遺伝子ノックアウト

八木 健

日本生理学雑誌 第59巻 第10号（平成9年）　1997/06

Molecular cloning of Fyn-associated molecules in the mouce central nervous system.

Kai N, Mishina M, Yagi T

1997/06　Research paper (scientific journal)

Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.

Asada H, Kawamura Y, Maruyama K, Kume H, Ding R-D, Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K

Proc Natl Acad Sci USA　Vol. 94　p. 6496-6499　1997/06　Research paper (scientific journal)

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brain but are susceptible to seizures.

Asada H, Kawamura Y, Maruyama K, Kume H, Ding R-G, Ji F-U, Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K

Biochem Biophys Res Commun　Vol. 229　p. 891-895　1996/12　Research paper (scientific journal)

Impairment of suckling response, trigeminal neuronal pattern formation and hippocampal LTD in NMDA receptor ε2 subunit mutant mice.

Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, Natsume R, Watanabe M, Inoue Y, Yagi T, Aizawa S, Arakawa M, Takahashi T, Nakamura Y, Mori H, Mishina M

Neuron　Vol. 16　p. 333-344　1996/12　Research paper (scientific journal)

Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.

Miyakawa T, Yagi T, Tateishi K, Niki H

Neuroreport　Vol. 7　p. 2723-2726　1996/12　Research paper (scientific journal)

Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness.

Miyakawa T, Yagi T, Kagiyama A, Niki H

Brain research. Molecular brain research　Vol. 37　No. 1/2　p. 145-150　1996/04　Research paper (scientific journal)

Physical and functional association of the cbl proto-oncogene product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling.

Tezuka T, Umemori H, Fusaki N, Yagi T, Takata M, Kurosaki T, Yamamoto T

J Exp Med.　Vol. 183　p. 675-680　1996/02　Research paper (scientific journal)

Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor.

Yasunaga M, Yagi T, Hanzawa N, Yasuda M, Yamanashi Y, Yamamoto T, Aizawa S, Miyauchi Y, Nishikawa S

1996/01　Research paper (scientific journal)

Experimental analysis of behavior of Fyn-tyrosine kinase-deficient mice

H Niki, T Miyakawa, T Yagi

BRAIN PROCESSES AND MEMORY　Vol. 1108　p. 279-290　1996　Research paper (international conference proceedings)

Molecular cloning of a novel serine/threonine kinase, MRK, possibly involved in cardiac development

Abe S, Yagi T, Ishiyama S, Hiroe M, Marumo F, Ikawa Y

1995/12　Research paper (scientific journal)

Reduced spontaneous activity of mice defective in the e4 subunit of the NMDA receptor channel.

Ikeda K, Araki K, Takayama C, Inoue Y, Yagi T, Aizawa S, Mishina M

1995/10　Research paper (scientific journal)

Stable production of mutant mice from double gene converted ES cells with puromycin and neomycin

Watanabe S, Kai N, Yasuda M, Kohmura N, Sanbo M, Mishina M, Yagi T

Biochem. Biophys. Res. Commun.　Vol. 213　p. 130-137　1995/08　Research paper (scientific journal)

A new strategy of gene trapping in ES cells using 3' RACE.

Yoshida M, Yagi T, Furuta Y, Takayanagi K, Kominami R, Takeda N, Tokunaga T, Chiba J, Ikawa Y, Aizawa S

Transgenic Res　Vol. 4　p. 277-287　1995/07　Research paper (scientific journal)

特集 遺伝子ターゲティング 特集によせて

八木 健

組織培養 21（２），35－37，1995　1995/06

Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta2 mutant mice.

Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, Takayama C, Inoue Y, Kutsuwada T, Yagi T, Kang Y, Aizawa S, Mishina M

Cell　Vol. 81　p. 245-252　1995/04　Research paper (scientific journal)

Enhanced susceptibility of audiogenic seizures in Fyn-kinase deficient mice.

Miyakawa T, Yagi T, Taniguchi M, Matsuura H, Tateishi K, Niki H

Brain research. Molecular brain research　Vol. 28　No. 2　p. 349-352　1995/02　Research paper (scientific journal)

Behaviral Abnormalities of Gene Targetted Mice.

YAGI Takeshi

Proceedings of The Japanese Society of Animal Models for Human Diseases　Vol. 11　p. 29-31　1995

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.

Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, Yagi T, Aizawa S, Inoue Y, Sugiyama H, Mishina M

Nature　Vol. 373　p. 151-155　1995/01　Research paper (scientific journal)

Gene targeting of fyn tyrosine kinase in murine nervous system. Genes for development, cell growth and infectious diseases,

Yagi T

1995/01　Research paper (scientific journal)

Increased fearfulness of Fyn tyrosine kinase deficient mice.

Miyakawa T, Yagi T, Watanabe S, Niki H

Brain research. Molecular brain research　Vol. 27　No. 1　p. 179-182　1994/12　Research paper (scientific journal)

Insulin resistance and growth retardation in mikce lacking insulin receptor substrate-1

Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S

Nature　Vol. 372　No. 6502　p. 182-6　1994/11　Research paper (scientific journal)

A novel nonreceptor tyrosine kinase, Srm; cloning and targeted disruption

Kohmura N, Yagi T, Tomooka Y, Oyanagi M, Kominami R, Takeda N, Chiba J, Ikawa Y, Aizawa S

1994/10　Research paper (scientific journal)

Fyn expression during neurogenesis in mouse embryo.

Yagi T, Shigetani Y, Furuta Y, Nada S, Okado N, Ikawa Y, Aizawa S

Oncogene　Vol. 9　No. 9　p. 2433-2440　1994/09　Research paper (scientific journal)

Src family kinases control neural development and function

Yagi T

Develop Growth Differ　Vol. 36　p. 543-550　1994/06　Research paper (scientific journal)

Initial events of myelination involve Fyn tyrosine kinase signalling.

Umemori H, Sato S, Yagi T, Aizawa S, Yamamoto T

Nature　Vol. 367　p. 572-576　1994/02　Research paper (scientific journal)

Non-receptor tyrosine kinases in mammalian neurogenesis.

Aizawa S, Yagi T, Furuta Y, Ikawa Y

Princess Takamatsu symposia　Vol. 24　p. 323-337　1994/01　Research paper (scientific journal)

A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice.

Yagi T, Aizawa S, Tokunaga T, Shigetani Y, Takeda N, Ikawa Y

Nature　Vol. 366　p. 742-745　1993/12　Research paper (scientific journal)

Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ

Yagi T, Shigetani Y, Okado N, Tokunaga T, Ikawa Y, Aizawa S

Oncogene　Vol. 8　p. 3343-3343　1993/12　Research paper (scientific journal)

Enhanced proliferative potential in culture of cells from p53-deficient mice

Tsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, Masuo I, Ikawa Y, Aizawa S

Oncogene　Vol. 8　p. 3313-3322　1993/12　Research paper (scientific journal)

A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene

Yagi T, Nada S, Watanabe N, Tamemoto H, Kohmura N, Ikawa Y, Aizawa S

Analytical Biochemistry　Vol. 214　No. 1　p. 77-86　1993/10　Research paper (scientific journal)

A novel ES cell line, TT2, with high germline-differentiating potency

Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, Tsukada T, Saga Y, Takeda N, Ikawa Y, Aizawa S

Analytical Biochemistry　Vol. 214　No. 1　p. 70-76　1993/10　Research paper (scientific journal)

マウス遺伝子ターゲティングの実際

塚田 晃代, 八木 健

実験医学 Vol.11 No.2(2月号）１９９３、実験医学 Vol.12 No.2(増刊号）１９９４　1993/06

Constitutive Activation of Src family kinase in mouse embryos that lack CskS.

Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S

Cell　Vol. 73　No. 6　p. 1125-1135　1993/06　Research paper (scientific journal)

A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells.

Horita K, Yagi T, Kohmura N, Tomooka Y, Ikawa Y, Aizawa S

1992/12　Research paper (scientific journal)

Mice develop normally without tenascin

Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S

Genes Dev　Vol. 6　p. 1821-1831　1992/10　Research paper (scientific journal)

A new method for negatively selecting random integrants using diphteria toxin A fragment gene: Efficacious isolation of homologous recombinants at c-fyn locus of mouse embryonic stem cells

Yagi T, Imamura T, Suda Y, Ikawa Y, Tokunaga T, Aizawa S

1992/01　Research paper (scientific journal)

Homologous recombination in ES cells

1991/12

ジフテリア毒素Aフラグメント遺伝子をネガティブ選別に用いる相同組換え細胞選別法

八木 健

細胞工学「Vol.10 No.6 408-415　1991/06

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection

Yagi T, Ikawa Y, Yoshida K, Shigetani Y, Takeda N, Mabuchi I, Yamamoto T, Aizawa S

Proc Natl Acad Sci U S A　Vol. 87　p. 9918-9922　1990/12　Research paper (scientific journal)

Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells

Aizawa S, Suda Y, Furuta Y, Yagi T, Takeda N, Watanabe N, Nagayoshi M, Ikawa Y

EMBO J.　Vol. 9　p. 2107-2116　1990/07　Research paper (scientific journal)

ES細胞を用いる変異マウスの作製―相同的組換えによる変異の導入

八木 健, 相沢 慎一

代謝VOL.27 増刊号「免疫'90」177-186　1990/06

Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659 to Glu659)

Suda Y, Aizawa S, Furuta Y, Yagi T, Ikawa Y, Saitoh K, Yamada Y, Toyoshima K, Yamamoto T

EMBO J.　Vol. 9　p. 181-190　1990/06　Research paper (scientific journal)