Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells.

Yu-Shen Cheng, Yukimasa Taniguchi, Yasuhiro Yunoki, Satomi Masai, Mizuho Nogi, Hatsuki Doi, Kiyotoshi Sekiguchi, Masato Nakagawa

Regenerative therapy　Vol. 25　p. 113-127　2024/03　Research paper (scientific journal)

ヒトエクリン汗腺におけるTRPチャネルの発現と機能の解析

Luo Qianwen, 加藤 寛子, 原 武史, 種村 篤, 中川 幸延, 室田 浩之, 富永 真琴, 関口 清俊, 藤田 郁尚

発汗学　Vol. 30　No. 2　p. 43-45　2023/12

Gap junction-mediated contraction of myoepithelial cells induces the peristaltic transport of sweat in human eccrine glands.

Kie Nakashima, Hiroko Kato, Ryuichiro Kurata, Luo Qianwen, Tomohisa Hayakawa, Fumihiro Okada, Fumitaka Fujita, Yukinobu Nakagawa, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Kiyotoshi Sekiguchi

Communications biology　Vol. 6　No. 1　p. 1175-1175　2023/11/18　Research paper (scientific journal)

Laminin fragments conjugated with perlecan's growth factor-binding domain differentiate human induced pluripotent stem cells into skin-derived precursor cells.

Yoriko Sugiyama-Nakagiri, Shiho Yamashita, Yukimasa Taniguchi, Chisei Shimono, Kiyotoshi Sekiguchi

Scientific reports　Vol. 13　No. 1　p. 14556-14556　2023/09/04　Research paper (scientific journal)

Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells

Ryoko Sato-Nishiuchi, Masamichi Doiguchi, Nanami Morooka, Kiyotoshi Sekiguchi

Journal of Cell Biology　Vol. 222　No. 9　2023/06/20　Research paper (scientific journal)

Visualization of basement membranes by a nidogen-based fluorescent reporter mice.

Futaki S, Horimoto A, Shimono C, Norioka N, Taniguchi Y, Hamaoka H, Kaneko M, Shigeta M, Abe T, Sekiguchi K, Kondo Y

Matrix Biology Plus　Vol. 18　2023/04　Research paper (scientific journal)

A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects

Jun-Ya Kaimori, Yamato Kikkawa, Daisuke Motooka, Tomoko Namba-Hamano, Ayako Takuwa, Atsuko Imai-Okazaki, Kaori Kobayashi, Arisa Tanigawa, Yuko Kotani, Yoshihiro Uno, Kazuto Yoshimi, Koki Hattori, Yuta Asahina, Sachio Kajimoto, Yohei Do, Tatsufumi Oka, Yusuke Sakaguchi, Tomoji Mashimo, Kiyotoshi Sekiguchi, Akihiro Nakaya, Motoyoshi Nomizu, Yoshitaka Isaka

JCI Insight　Vol. 7　No. 23　2022/12　Research paper (scientific journal)

Dynamics, structure and assembly of the basement membrane in developing salivary glands revealed by an exogenous EGFP-tagged nidogen probe

Yuichi Kadoya, Sugiko Futaki, Chisei Shimono, Taketoshi Kimura, Kiyotoshi Sekiguchi

Microscopy　2022/08/11　Research paper (scientific journal)

Pretreatment with Perlecan-Conjugated Laminin-E8 Fragment Enhances Maturation of Grafted Dopaminergic Progenitors in Parkinson's Disease Model.

Hiromasa Adachi, Asuka Morizane, Sadaharu Torikoshi, Fabian Raudzus, Yukimasa Taniguchi, Susumu Miyamoto, Kiyotoshi Sekiguchi, Jun Takahashi

Stem Cells Translational Medicine　Vol. 11　No. 7　p. 767-777　2022/07/20　Research paper (scientific journal)

Establishment and characterization of immortalized sweat gland myoepithelial cells

Tomohisa Hayakawa, Fumitaka Fujita, Fumihiro Okada, Kiyotoshi Sekiguchi

Scientific Reports　Vol. 12　No. 1　2022/01　Research paper (scientific journal)

Clear Evidence of LAMA5 Gene Biallelic Truncating Variants Causing Infantile Nephrotic Syndrome.

Yukimasa Taniguchi, China Nagano, Kiyotoshi Sekiguchi, Atsushi Tashiro, Noriko Sugawara, Haruhide Sakaguchi, Chisato Umeda, Yuya Aoto, Shinya Ishiko, Rini Rossanti, Nana Sakakibara, Tomoko Horinouchi, Tomohiko Yamamura, Atsushi Kondo, Sadayuki Nagai, Hiroaki Nagase, Kazumoto Iijima, Jeffrey H Miner, Kandai Nozu

Kidney360　Vol. 2　No. 12　p. 1968-1978　2021/12/30　Research paper (scientific journal)

Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in an acute infarct rat heart.

Nagako Sougawa, Shigeru Miyagawa, Takuji Kawamura, Ryohei Matsuura, Akima Harada, Yoshiki Sakai, Noriko Mochizuki-Oda, Ryoko Sato-Nishiuchi, Kiyotoshi Sekiguchi, Yoshiki Sawa

Scientific reports　Vol. 11　No. 1　p. 22243-22243　2021/11/15　Research paper (scientific journal)

Structural mechanism of laminin recognition by integrin

Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi

Nature Communications　Vol. 12　No. 1　2021/06　Research paper (scientific journal)

Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin beta1-ILK-beta-catenin-JUN axis.

Yuzuriha A, Nakamura S, Sugimoto N, Kihara S, Nakagawa M, Yamamoto T, Sekiguchi K, Eto K

Stem Cell Res　Vol. 53　p. 102287-102287　2021/05　Research paper (scientific journal)

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, Hironobu Fujiwara

Nature Communications　Vol. 12　No. 1　2021/05　Research paper (scientific journal)

Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos

Daiji KIYOZUMI, Shunsuke YAGUCHI, Junko YAGUCHI, Atsuko YAMAZAKI, Kiyotoshi SEKIGUCHI

Experimental Animals　Vol. 70　No. 3　p. 378-386　2021/04　Research paper (scientific journal)

Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm

Sandy Elbitar, Marjolijn Renard, Pauline Arnaud, Nadine Hanna, Marie-Paule Jacob, Dong-Chuan Guo, Ko Tsutsui, Marie-Sylvie Gross, Ketty Kessler, Laurent Tosolini, Vincenzo Dattilo, Sebastien Dupont, Jeremie Jonquet, Maud Langeois, Louise Benarroch, Melodie Aubart, Youmna Ghaleb, Yara Abou Khalil, Mathilde Varret, Petra El Khoury, Benoit Ho-Tin-Noé, Yves Alembik, Sébastien Gaertner, Bertrand Isidor, Laurent Gouya, Olivier Milleron, Kiyotoshi Sekiguchi, Dianna Milewicz, Julie De Backer, Carine Le Goff, Jean-Baptiste Michel, Guillaume Jondeau, Lynn Y. Sakai, Catherine Boileau, Marianne Abifadel

Genetics in Medicine　2020/08/28　Research paper (scientific journal)

Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model

Takaaki Samura, Shigeru Miyagawa, Takuji Kawamura, Satsuki Fukushima, Jun-Ya Yokoyama, Maki Takeda, Akima Harada, Fumiya Ohashi, Ryoko Sato-Nishiuchi, Toshihiko Toyofuku, Koichi Toda, Kiyotoshi Sekiguchi, Yoshiki Sawa

Journal of the American Heart Association　Vol. 9　No. 16　2020/08　Research paper (scientific journal)

Bipartite mechanism for laminin-integrin interactions: Identification of the integrin binding site in LG domains of the laminin alpha chain

Taniguchi, Y, Takizawa, M, Li, S, Sekiguchi, K

Matrix Biol.　Vol. 87　p. 66-76　2020/05　Research paper (scientific journal)

Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium.

Shun Shibata, Ryuhei Hayashi, Yuji Kudo, Toru Okubo, Tsutomu Imaizumi, Tomohiko Katayama, Yuki Ishikawa, Yuki Kobayashi, Junko Toga, Yukimasa Taniguchi, Yoichi Honma, Kiyotoshi Sekiguchi, Kohji Nishida

Stem Cell Reports　Vol. 14　No. 4　p. 663-676　2020/04/14　Research paper (scientific journal)

A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation.

Nawin Chanthra, Tomoyuki Abe, Matthew Miyamoto, Kiyotoshi Sekiguchi, Chulan Kwon, Yutaka Hanazono, Hideki Uosaki

Scientific Reports　Vol. 10　No. 1　p. 4249-4249　2020/03/06　Research paper (scientific journal)

Laminin is the ECM niche for trophoblast stem cells

Kiyosumi, D, Nakano, I, Sato-Nishiuchi, R, Sekiguchi, K

Life Sci. Alliance　Vol. 3　No. 2　2020/01/14　Research paper (scientific journal)

Laminin alpha2, alpha4, and alpha5 chains positively regulate migration and survival of oligodendrocyte precursor cells

Suzuki, N, Hyodo, M, Hayashi, C, Mabuchi, Y, Sekimoto, K, Onchi, C, Sekiguchi, K, Akazawa, C

S. Rep.　Vol. 9　2019/12　Research paper (scientific journal)

Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease

Tomo Kamitani, Hiroyuki Murota, Noriko Arase, Mari Wataya-Kaneda, Ryoko Sato-Nishiuchi, Kiyotoshi Sekiguchi, Daisuke Okuzaki, Daisuke Motooka, Ichiro Katayama

Journal of Dermatological Science　Vol. 96　No. 2　p. 73-80　2019/11　Research paper (scientific journal)

Polydomはフォン・レックリングハウゼン病の皮膚型神経線維腫形成メカニズムに関与する

神谷 智, 室田 浩之, 荒瀬 規子, 金田 眞理, 佐藤 涼子, 関口 清俊, 奥崎 大介, 元岡 大祐, 片山 一朗

日本レックリングハウゼン病学会雑誌　Vol. 10　No. 1　p. 41-42　2019/07

Molecular profiling of the basement membrane of pluripotent epiblast cells in post-implantation stage mouse embryos

Futaki S, Nakano I, Kawasaki M, Sanzen N, Sekiguchi K

Regenerative Therapy　Vol. 12　p. 55-65　2019/05

Laminin-511 supplementation enhances stem cell localization with suppression in the decline of cardiac function in acute infarct rats

Sougawa, N, Miyagaswa, S, Fukushima, S, Yokoyama, J, Kitahara, M, Harada, A, Mochizuki-Oda, N, Sato-Nishiuchi, R, Sekiguchi, K, Sawa, Y

Transplantation　Vol. 103　No. 5　p. e119-e127　2019/05　Research paper (scientific journal)

Development of cell therapy for muscular dystrophy by iPSC-derived muscle stem cell

Sakurai Hidetoshi, Zhao Mingming, Takenaka Nana, Sato Masae, Takayama Satoru, Tazumi Atsutoshi, Ikeya Makoto, Hotta Akitsu, Ito Yuta, Sekiguchi Kiyotoshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.

Yuya Sato, Daiji Kiyozumi, Sugiko Futaki, Itsuko Nakano, Chisei Shimono, Naoko Kaneko, Masahito Ikawa, Masaru Okabe, Kazunobu Sawamoto, Kiyotoshi Sekiguchi

Molecular biology of the cell　Vol. 30　No. 1　p. 56-68　2019/01/01　Research paper (scientific journal)

Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.

Shun Shibata, Ryuhei Hayashi, Toru Okubo, Yuji Kudo, Tomohiko Katayama, Yuki Ishikawa, Junko Toga, Emiko Yagi, Yoichi Honma, Andrew J Quantock, Kiyotoshi Sekiguchi, Kohji Nishida

Cell reports　Vol. 25　No. 6　p. 1668-1679　2018/11/06　Research paper (scientific journal)

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.

Kiyozumi, D, Taniguchi, Y, Nakano, I, Toga, J, Yagi, E, Hasuwa, H, Ikawa, M, Sekiguchi, K

Life Science Alliance　Vol. 1　No. 5　2018/09　Research paper (scientific journal)

Laminin 511 is a target antigen in autoimmune pancreatitis

Masahiro Shiokawa, Yuzo Kodama, Kiyotoshi Sekiguchi, Takeshi Kuwada, Teruko Tomono, Katsutoshi Kuriyama, Hajime Yamazaki, Toshihiro Morita, Saiko Marui, Yuko Sogabe, Nobuyuki Kakiuchi, Tomoaki Matsumori, Atsushi Mima, Yoshihiro Nishikawa, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Takahisa Maruno, Norimitsu Uza, Tatsuaki Tsuruyama, Tsuneyo Mimori, Hiroshi Seno, Tsutomu Chiba

Science Translational Medicine　Vol. 10　No. 453　2018/08/08　Research paper (scientific journal)

Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8

Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Takashi Ikejima, Shunji Hattori

Regenerative Therapy　Vol. 8　p. 73-79　2018/06/01　Research paper (scientific journal)

エクリン汗腺の構造と動態観察による発汗制御メカニズムの解明

室田 浩之, 谷 佐起, 山賀 康右, 小野 慧美, 田村 淳, 菊田 順一, 近江 雅人, 月田 早智子, 石井 優, 関口 清俊, 片山 一朗

日本皮膚科学会雑誌　Vol. 128　No. 5　p. 1173-1173　2018/05

Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro.

Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa

Stem cell reports　Vol. 10　No. 2　p. 568-582　2018/02/13　Research paper (scientific journal)

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

Takayama, K, Hagihara, Y, Toba, Y, Sekiguchi, K, Sakurai, F, Mizuguchi, H

Biomaterials　Vol. 161　p. 24-32　2018/01　Research paper (scientific journal)

Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.

Yoshida, S, Hasegawa, T, Suzuki, M, Sugeno, N, Kobayashi, J, Ueyama, M, Fukuda, M, Ido-Fujibayashi, A, Sekiguchi, K, Ezura, M, Kikuchi, A, Baba, T, Takeda, A, Mochizuki, H, Nagai, Y, Aoki, M

Hum. Mol. Genet.,　Vol. 27　p. 823-836　2018/01　Research paper (scientific journal)

Recombinant laminin fragments endowed with collagen-binding activity: A tool for conferring laminin-like cell-adhesive activity to collagen matrices

Ryoko Sato-Nishiuchi, Shaoliang Li, Fumi Ebisu, Kiyotoshi Sekiguchi

Matrix Biology　Vol. 65　p. 75-90　2018/01/01　Research paper (scientific journal)

Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.

Takayama, K, Akita, N, Mimura, N, Akahira, r, Taniguchi, Y, Ikeda, M, Sakurai, F, Ohara, O, Morio, T, Sekiguchi, K, Mizuguchi, H

Hepatol. Common.　Vol. 1　p. 1058-1069　2017/08　Research paper (scientific journal)

Probing the acidic residue within the integrin binding site of laminin-511 that interacts with the metal ion-dependent adhesion site of α6β1 integrin

Yukimasa Taniguchi, Shaoliang Li, Mamoru Takizawa, Eriko Oonishi, Junko Toga, Emiko Yagi, Kiyotoshi Sekiguchi

Biochemical and Biophysical Research Communications　Vol. 487　No. 3　p. 525-531　2017/06/03　Research paper (scientific journal)

Mechanistic basis for the recognition of laminin-511 by α6β1 integrin.

Takizawa, M, Arimori, T, Taniguchi, Y, Kitago, Y, Yamashita, E, Takagi, J, Sekiguchi, K

Science Advances　Vol. 3　2017/06　Research paper (scientific journal)

Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining

Ryuichiro Kurata, Sugiko Futaki, Itsuko Nakano, Fumitaka Fujita, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Fumihiro Okada, Kiyotoshi Sekiguchi

PLOS ONE　Vol. 12　No. 6　2017/06　Research paper (scientific journal)

Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells

Ryuhei Hayashi, Yuki Ishikawa, Ryousuke Katori, Yuzuru Sasamoto, Yuki Taniwaki, Hiroshi Takayanagi, Motokazu Tsujikawa, Kiyotoshi Sekiguchi, Andrew J. Quantock, Kohji Nishida

NATURE PROTOCOLS　Vol. 12　No. 4　p. 683-696　2017/04　Research paper (scientific journal)

Polydom is an extracellular matrix protein involved in lymphatic vessel remodeling.

Morooka, N, Futaki, S, Sato-Nishiuchi, R, Nishino, M, Totani, Y, Shimono, C, Nakano, I, Nakajima, H, Mochizuki, N, Sekiguchi, K

Circ.Res.　Vol. 120　p. 1276-1288　2017/02　Research paper (scientific journal)

An evolutionarily conserved role for polydom/svep1 during lymphatic vessel formation.

Karpanen, T, Padberg, Y, van de Pavert, SA, Dierkes, C, Morooka, N, Peterson-Maduro, J, van de Hoek, G, Adrian, M, Mochizuki, N, Sekiguchi, K, Kiefer, F, Schulte, D, Schulte-Merker, S

Circ.Res.　Vol. 120　p. 1263-1275　2017/02　Research paper (scientific journal)

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain.

Fujioka, T, Kaneko, N, Ajioka, I, Nakaguchi, K, Omata, T, Ohba, H, Fassler, R, Garc?a-Verdugo, JM, Sekiguchi, K, Matsukawa, N, Sawamoto, K

EBioMedicine.　Vol. 16　p. 195-203　2017/01　Research paper (scientific journal)

CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling

Yongkang Qiao, John Kit Chung Tam, Sheryl S. L. Tan, Yee Kit Tai, Chin Yein Chin, Alastair G. Stewart, Leonie Ashman, Kiyotoshi Sekiguchi, Shenna Y. Langenbach, Gerald Stelmack, Andrew J. Halayko, Thai Tran

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 139　No. 1　p. 82-+　2017/01　Research paper (scientific journal)

Sweat gland stem cells in gland homeostasis and regeneration.

Kurata, R, Sekiguchi, K

Skin Care　Vol. 11　No. 6　p. 39-43　2016/12　Research paper (scientific journal)

Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells

Ryo Ohta, Akira Niwa, Yukimasa Taniguchi, Naoya M. Suzuki, Junko Toga, Emiko Yagi, Norikazu Saiki, Yoko Nishinaka-Arai, Chihiro Okada, Akira Watanabe, Tatsutoshi Nakahata, Kiyotoshi Sekiguchi, Megumu K. Saito

SCIENTIFIC REPORTS　Vol. 6　2016/11　Research paper (scientific journal)

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

Kazuo Takayama, Seiji Mitani, Yasuhito Nagamoto, Fuminori Sakurai, Masashi Tachibana, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 474　No. 1　p. 91-96　2016/05　Research paper (scientific journal)

Molecular Basis of the Ligand Binding Specificity of alpha v beta 8 Integrin

Akio Ozawa, Yuya Sato, Tsukasa Imabayashi, Toshihiko Uemura, Junichi Takagi, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 291　No. 22　p. 11551-11565　2016/05　Research paper (scientific journal)

Co-ordinated ocular development from human iPS cells and recovery of corneal function

Ryuhei Hayashi, Yuki Ishikawa, Yuzuru Sasamoto, Ryosuke Katori, Naoki Nomura, Tatsuya Ichikawa, Saori Araki, Takeshi Soma, Satoshi Kawasaki, Kiyotoshi Sekiguchi, Andrew J. Quantock, Motokazu Tsujikawa, Kohji Nishida

NATURE　Vol. 531　No. 7594　p. 376-+　2016/03　Research paper (scientific journal)

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.

Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Takahashi K, Yamanaka S, Saitou M

Cell Stem Cell　Vol. 17　No. 2　p. 178-194　2015/08　Research paper (scientific journal)

SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.

Nakamura T, Yabuta Y, Okamoto I, Aramaki S, Yokobayashi S, Kurimoto K, Sekiguchi K, Nakagawa M, Yamamoto T, Saitou M

Nucleic Acids Res.　Vol. 43　No. 9　2015/05　Research paper (scientific journal)

N-linked glycosylation on laminin gamma 1 influences recognition of anti-laminin gamma 1 pemphigoid autoantibodies

Xiaoguang Li, Hua Qian, Mamoru Takizawa, Hiroshi Koga, Atsunari Tsuchisaka, Norito Ishii, Taihei Hayakawa, Koji Ohara, Cassian Sitaru, Detlef Zillikens, Kiyotoshi Sekiguchi, Yoshiaki Hirako, Takashi Hashimoto

JOURNAL OF DERMATOLOGICAL SCIENCE　Vol. 77　No. 2　p. 125-129　2015/02　Research paper (scientific journal)

The alpha 4 beta 1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts

Arti V. Shinde, Rhiannon Kelsh, John H. Peters, Kiyotoshi Sekiguchi, Livingston Van De Water, Paula J. McKeown-Longo

MATRIX BIOLOGY　Vol. 41　p. 26-35　2015/01　Research paper (scientific journal)

Molecular Basis of Laminin-Integrin Interactions

Masashi Yamada, Kiyotoshi Sekiguchi

BASEMENT MEMBRANES　Vol. 76　p. 197-229　2015　Part of collection (book)

Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet

Takashi Yoshino, Daisuke Saito, Yuji Atsuta, Chihiro Uchiyama, Shinya Ueda, Kiyotoshi Sekiguchi, Yoshiko Takahashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 18　p. 6660-6665　2014/05　Research paper (scientific journal)

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

Daisuke Doi, Bumpei Samata, Mitsuko Katsukawa, Tetsuhiro Kikuchi, Asuka Morizane, Yuichi Ono, Kiyotoshi Sekiguchi, Masato Nakagawa, Malin Parmar, Jun Takahashi

STEM CELL REPORTS　Vol. 2　No. 3　p. 337-350　2014/03　Research paper (scientific journal)

In situ detection of integrin ligands

Daiji Kiyozumi, Ryoko Sato-Nishiuchi, Kiyotoshi Sekiguchi

Current Protocols in Cell Biology　Vol. 2014　p. 9.7.1-9.7.17　2014　Research paper (scientific journal)

Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin

Ryuichiro Kurata, Sugiko Futaki, Itsuko Nakano, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Kiyotoshi Sekiguchi

CELL STRUCTURE AND FUNCTION　Vol. 39　No. 2　p. 101-112　2014　Research paper (scientific journal)

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

Masato Nakagawa, Yukimasa Taniguchi, Sho Senda, Nanako Takizawa, Tomoko Ichisaka, Kanako Asano, Asuka Morizane, Daisuke Doi, Jun Takahashi, Masatoshi Nishizawa, Yoshinori Yoshida, Taro Toyoda, Kenji Osafune, Kiyotoshi Sekiguchi, Shinya Yamanaka

SCIENTIFIC REPORTS　Vol. 4　2014/01　Research paper (scientific journal)

Disease-associated single amino acid mutation in the calf-1 domain of integrin α3 leads to defects in its processing and cell surface expression

Masashi Yamada, Kiyotoshi Sekiguchi

Biochemical and Biophysical Research Communications　Vol. 441　No. 4　p. 988-993　2013/11/29　Research paper (scientific journal)

GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development

Sung-Jin Jeong, Rong Luo, Kathleen Singer, Stefanie Giera, Jordan Kreidberg, Daiji Kiyozumi, Chisei Shimono, Kiyotoshi Sekiguchi, Xianhua Piao

PLoS ONE　Vol. 8　No. 7　2013/07/09　Research paper (scientific journal)

Nephronectin binds to heparan sulfate proteoglycans via its MAM domain

Yuya Sato, Chisei Shimono, Shaoliang Li, Itsuko Nakano, Naoko Norioka, Nobuo Sugiura, Koji Kimata, Masashi Yamada, Kiyotoshi Sekiguchi

MATRIX BIOLOGY　Vol. 32　No. 3-4　p. 188-195　2013/04　Research paper (scientific journal)

Erratum: Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells (Nature Communications (2012) 3 (1236) DOI:10.1038/ncomms2231)

T. Miyazaki, S. Futaki, H. Suemori, Y. Taniguchi, M. Yamada, M. Kawasaki, M. Hayashi, H. Kumagai, N. Nakatsuji, K. Sekiguchi, E. Kawase

Nature Communications　Vol. 4　2013

Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells

Masashi Yamada, Gabriele Mugnai, Satoshi Serada, Yoshiko Yagi, Tetsuji Naka, Kiyotoshi Sekiguchi

Cell Adhesion and Migration　Vol. 7　No. 3　p. 304-314　2013　Research paper (scientific journal)

Brca1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

Panagiota A. Sotiropoulou, Andrea E. Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers, Cedric Blanpain

Genes and Development　Vol. 27　No. 1　p. 39-51　2013/01/01　Research paper (scientific journal)

Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development

Xiaohong Song, Yuya Sato, Kiyotoshi Sekiguchi, Hideaki Tanaka, Kunimasa Ohta

Developmental Dynamics　Vol. 242　No. 1　p. 23-29　2013/01　Research paper (scientific journal)

Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells

Fuyuki F. Inagaki, Minoru Tanaka, Natsuko F. Inagaki, Tomoki Yagai, Yuya Sato, Kiyotoshi Sekiguchi, Naoki Oyaizu, Norihiro Kokudo, Atsushi Miyajima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 430　No. 2　p. 751-756　2013/01　Research paper (scientific journal)

Recombinant E8 fragments of human laminin isoforms support long-term culture of human pluripotent stem cells under defined and xeno-free culture conditions.

Miyazaki, T, Futaki, S, Suemori, H, Taniguchi,Y, Kawasaki, M, Hayashi, M, Kumagai,H, Nakatsuji, N, Sekiguchi, K, Kawase, E

Nature Communications 13, 1236.　2012/12

Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

Makoto Nasu, Nozomu Takata, Teruko Danjo, Hideya Sakaguchi, Taisuke Kadoshima, Sugiko Futaki, Kiyotoshi Sekiguchi, Mototsugu Eiraku, Yoshiki Sasai

PLOS ONE　Vol. 7　No. 12　2012/12　Research paper (scientific journal)

Schwann cell myelination requires integration of laminin activities

Karen K. Mckee, Dong-Hua Yang, Rajesh Patel, Zu-Lin Chen, Sidney Strickland, Junichi Takagi, Kiyotoshi Sekiguchi, Peter D. Yurchenco

JOURNAL OF CELL SCIENCE　Vol. 125　No. 19　p. 4609-4619　2012/10　Research paper (scientific journal)

Equarin is involved as an FGF signaling modulator in chick lens differentiation

Xiaohong Song, Yuya Sato, Athary Felemban, Ayako Ito, Mahmud Hossain, Hiroshi Ochiai, Takashi Yamamoto, Kiyotoshi Sekiguchi, Hideaki Tanaka, Kunimasa Ohta

DEVELOPMENTAL BIOLOGY　Vol. 368　No. 1　p. 109-117　2012/08　Research paper (scientific journal)

Polydom/SVEP1 Is a Ligand for Integrin alpha 9 beta 1

Ryoko Sato-Nishiuchi, Itsuko Nakano, Akio Ozawa, Yuya Sato, Makiko Takeichi, Daiji Kiyozumi, Kiyoshi Yamazaki, Teruo Yasunaga, Sugiko Futaki, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 287　No. 30　p. 25615-25630　2012/07　Research paper (scientific journal)

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

Tokushige Nakano, Satoshi Ando, Nozomu Takata, Masako Kawada, Keiko Muguruma, Kiyotoshi Sekiguchi, Koichi Saito, Shigenobu Yonemura, Mototsugu Eiraku, Yoshiki Sasai

CELL STEM CELL　Vol. 10　No. 6　p. 771-785　2012/06　Research paper (scientific journal)

Basement membrane assembly of the integrin alpha 8 beta 1 ligand nephronectin requires Fraser syndrome-associated proteins

Daiji Kiyozumi, Makiko Takeichi, Itsuko Nakano, Yuya Sato, Tomohiko Fukuda, Kiyotoshi Sekiguchi

JOURNAL OF CELL BIOLOGY　Vol. 197　No. 5　p. 677-689　2012/05　Research paper (scientific journal)

Cross-talk between Integrin alpha 6 beta 4 and Insulin-like Growth Factor-1 Receptor (IGF1R) through Direct alpha 6 beta 4 Binding to IGF1 and Subsequent alpha 6 beta 4-IGF1-IGF1R Ternary Complex Formation in Anchorage-independent Conditions

Masaaki Fujita, Katsuaki Ieguchi, Parastoo Davari, Satoshi Yamaji, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Yoko K. Takada, Yoshikazu Takada

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 287　No. 15　p. 12491-12500　2012/04　Research paper (scientific journal)

Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development

Richard Wilson, Emma L. Norris, Bent Brachvogel, Constanza Angelucci, Snezana Zivkovic, Lavinia Gordon, Bianca C. Bernardo, Jacek Stermann, Kiyotoshi Sekiguchi, Jeffrey J. Gorman, John F. Bateman

Molecular and Cellular Proteomics　Vol. 11　No. 1　2012/01　Research paper (scientific journal)

Microenvironmental Regulation by Fibrillin-1

Gerhard Sengle, Ko Tsutsui, Douglas R. Keene, Sara F. Tufa, Eric J. Carlson, Noe L. Charbonneau, Robert N. Ono, Takako Sasaki, Mary K. Wirtz, John R. Samples, Liselotte I. Fessler, John H. Fessler, Kiyotoshi Sekiguchi, Susan J. Hayflick, Lynn Y. Sakai

PLOS GENETICS　Vol. 8　No. 1　2012/01　Research paper (scientific journal)

Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons

Eri Fusaoka-Nishioka, Chisei Shimono, Yukimasa Taniguchi, Aki Togawa, Akio Yamada, Eiji Inoue, Hiroshi Onodera, Kiyotoshi Sekiguchi, Toshio Imai

NEUROSCIENCE RESEARCH　Vol. 71　No. 4　p. 421-426　2011/12　Research paper (scientific journal)

Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility

Takahisa Takino, Ryota Nagao, Ri-ichiroh Manabe, Takahiro Domoto, Kiyotoshi Sekiguchi, Hiroshi Sato

FEBS LETTERS　Vol. 585　No. 21　p. 3378-3384　2011/11　Research paper (scientific journal)

ADAMTSL6 beta Protein Rescues Fibrillin-1 Microfibril Disorder in a Marfan Syndrome Mouse Model through the Promotion of Fibrillin-1 Assembly

Masahiro Saito, Misaki Kurokawa, Masahito Oda, Masamitsu Oshima, Ko Tsutsui, Kazutaka Kosaka, Kazuhisa Nakao, Miho Ogawa, Ri-ichiroh Manabe, Naoto Suda, Ganburged Ganjargal, Yasunobu Hada, Toshihide Noguchi, Toshio Teranaka, Kiyotoshi Sekiguchi, Toshiyuki Yoneda, Takashi Tsuji

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 44　p. 38602-38613　2011/11　Research paper (scientific journal)

Heterozygous Mutations of FREM1 Are Associated with an Increased Risk of Isolated Metopic Craniosynostosis in Humans and Mice

Lisenka E. L. M. Vissers, Timothy C. Cox, A. Murat Maga, Kieran M. Short, Fenny Wiradjaja, Irene M. Janssen, Fernanda Jehee, Debora Bertola, Jia Liu, Garima Yagnik, Kiyotoshi Sekiguchi, Daiji Kiyozumi, Hans van Bokhoven, Carlo Marcelis, Michael L. Cunningham, Peter J. Anderson, Simeon A. Boyadjiev, Maria Rita Passos-Bueno, Joris A. Veltman, Ian Smyth, Michael F. Buckley, Tony Roscioli

PLOS GENETICS　Vol. 7　No. 9　2011/09　Research paper (scientific journal)

Fused pulmonary lobes is a rat model of human Fraser syndrome

Daiji Kiyozumi, Itsuko Nakano, Ken L. Takahashi, Hitoshi Hojo, Hiroaki Aoyama, Kiyotoshi Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 411　No. 2　p. 440-444　2011/07　Research paper (scientific journal)

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the alpha 2 beta 1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) A DUAL RECEPTOR ANTAGONISM

Atul Goyal, Nutan Pal, Matthew Concannon, Matthew Paul, Mike Doran, Chiara Poluzzi, Kiyotoshi Sekiguchi, John M. Whitelock, Thomas Neill, Renato V. Iozzo

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 29　p. 25947-25962　2011/07　Research paper (scientific journal)

Self-organizing optic-cup morphogenesis in three-dimensional culture.

Eiraku, M, Takata, N, Ishibashi, H, Kawada, M, Sakakura, E, Okuda, S, Sekiguchi, K, Adachi, T, Sasai, Y

Nature　Vol. 472　No. 7341　p. 51-56　2011/07　Research paper (scientific journal)

Identification of genes expressed during hair follicle induction

Daiji Kiyozumi, Aki Osada, Nagisa Sugimoto, Charles N. Weber, Yuichi Ono, Toshio Imai, Akiko Okada, Kiyotoshi Sekiguchi

JOURNAL OF DERMATOLOGY　Vol. 38　No. 7　p. 674-679　2011/07　Research paper (scientific journal)

Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2

Besa Xhabija, Gregory S. Taylor, Akemi Fujibayashi, Kiyotoshi Sekiguchi, Panayiotis O. Vacratsis

FEBS LETTERS　Vol. 585　No. 12　p. 1722-1728　2011/06　Research paper (scientific journal)

Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers

Taizo Mori, Yoshinobu Kariya, Eriko Komiya, Shouichi Higashi, Yohei Miyagi, Kiyotoshi Sekiguchi, Kaoru Miyazaki

CANCER SCIENCE　Vol. 102　No. 5　p. 1095-1100　2011/05　Research paper (scientific journal)

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

Hironobu Fujiwara, Manuela Ferreira, Giacomo Donati, Denise K. Marciano, James M. Linton, Yuya Sato, Andrea Hartner, Kiyotoshi Sekiguchi, Louis F. Reichardt, Fiona M. Watt

CELL　Vol. 144　No. 4　p. 577-589　2011/02　Research paper (scientific journal)

Activin A Binds to Perlecan through Its Pro-region That Has Heparin/Heparan Sulfate Binding Activity

Shaoliang Li, Chisei Shimono, Naoko Norioka, Itsuko Nakano, Tetsuo Okubo, Yoshiko Yagi, Maria Hayashi, Yuya Sato, Hitomi Fujisaki, Shunji Hattori, Nobuo Sugiura, Koji Kimata, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 47　p. 36645-36655　2010/11　Research paper (scientific journal)

Direct Binding of the EGF-like Domain of Neuregulin-1 to Integrins (alpha v beta 3 and alpha 6 beta 4) Is Involved in Neuregulin-1/ErbB Signaling

Katsuaki Ieguchi, Masaaki Fujita, Zi Ma, Parastoo Davari, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Bobby Wang, Yoko K. Takada, Yoshikazu Takada

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 41　p. 31388-31398　2010/10　Research paper (scientific journal)

Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme

Yukako Uchiyama, Masaji Sakaguchi, Takeshi Terabayashi, Toshiaki Inenaga, Shuji Inoue, Chiyoko Kobayashi, Naoko Oshima, Hiroshi Kiyonari, Naomi Nakagata, Yuya Sato, Kiyotoshi Sekiguchi, Hiroaki Miki, Eiichi Araki, Sayoko Fujimura, Satomi S. Tanaka, Ryuichi Nishinakamura

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 20　p. 9240-9245　2010/05　Research paper (scientific journal)

Genetic Analysis of Fin Development in Zebrafish Identifies Furin and Hemicentin 1 as Potential Novel Fraser Syndrome Disease Genes

Thomas J. Carney, Natalia Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M. Gebauer, Jared Coffin Talbot, Charles B. Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W. Ingham, Matthias Hammerschmidt

PLOS GENETICS　Vol. 6　No. 4　2010/04　Research paper (scientific journal)

Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system

Chisei Shimono, Ri-ichiroh Manabe, Tomiko Yamada, Shiro Fukuda, Jun Kawai, Yutaka Furutani, Ko Tsutsui, Kazuhiro Ikenaka, Yoshihide Hayashizaki, Kiyotoshi Sekiguchi

JOURNAL OF BIOCHEMISTRY　Vol. 147　No. 4　p. 565-579　2010/04　Research paper (scientific journal)

Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor

Shigenori Miura, Kaori Mitsui, Takahiro Heishi, Chisa Shukunami, Kiyotoshi Sekiguchi, Jun Kondo, Yasufumi Sato, Yuji Hiraki

Experimental Cell Research　Vol. 316　No. 5　p. 775-788　2010/03/10　Research paper (scientific journal)

Laminin gamma 2 fragments are increased in the circulation of patients with early phase acute lung injury

Masahiko Katayama, Akitoshi Ishizaka, Michiie Sakamoto, Seitaro Fujishima, Kiyotoshi Sekiguchi, Koichiro Asano, Tomoko Betsuyaku, Toru Kotani, Lorraine B. Ware, Michael A. Matthay, Satoru Hashimoto

INTENSIVE CARE MEDICINE　Vol. 36　No. 3　p. 479-486　2010/03　Research paper (scientific journal)

ADAMTSL-6 Is a Novel Extracellular Matrix Protein That Binds to Fibrillin-1 and Promotes Fibrillin-1 Fibril Formation

Ko Tsutsui, Ri-ichiroh Manabe, Tomiko Yamada, Itsuko Nakano, Yasuko Oguri, Douglas R. Keene, Gerhard Sengle, Lynn Y. Sakai, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 7　p. 4870-4882　2010/02　Research paper (scientific journal)

Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support

Sanna Vuoristo, Ismo Virtanen, Minna Takkunen, Jaan Palgi, Yamato Kikkawa, Patricia Rousselle, Kiyotoshi Sekiguchi, Timo Tuuri, Timo Otonkoski

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE　Vol. 13　No. 8B　p. 2622-2633　2009/08　Research paper (scientific journal)

Molecular Basis of the Recognition of Nephronectin by Integrin alpha 8 beta 1

Yuya Sato, Toshihiko Uemura, Keisuke Morimitsu, Ryoko Sato-Nishiuchi, Ri-ichiroh Manabe, Junichi Takagi, Masashi Yamada, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 21　p. 14524-14536　2009/05　Research paper (scientific journal)

The C-terminal Region of Laminin beta Chains Modulates the Integrin Binding Affinities of Laminins

Yukimasa Taniguchi, Hiroyuki Ido, Noriko Sanzen, Maria Hayashi, Ryoko Sato-Nishiuchi, Sugiko Futaki, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 12　p. 7820-7831　2009/03　Research paper (scientific journal)

Anti-laminin gamma-1 pemphigoid

Teruki Dainichi, Sadamu Kurono, Bungo Ohyama, Norito Ishii, Noriko Sanzen, Maria Hayashi, Chisei Shimono, Yukimasa Taniguchi, Hiroshi Koga, Tadashi Karashima, Shinichiro Yasumoto, Detlef Zillikens, Kiyotoshi Sekiguchi, Takashi Hashimoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 8　p. 2800-2805　2009/02　Research paper (scientific journal)

N-Glycosylation of Laminin-332 Regulates Its Biological Functions A NOVEL FUNCTION OF THE BISECTING GlcNAc

Yoshinobu Kariya, Rika Kato, Satsuki Itoh, Tomohiko Fukuda, Yukinao Shibukawa, Noriko Sanzen, Kiyotoshi Sekiguchi, Yoshinao Wada, Nana Kawasaki, Jianguo Gu

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 48　p. 33036-33045　2008/11　Research paper (scientific journal)

Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex

Masashi Yamada, Yumiko Tamura, Noriko Sanzen, Ryoko Sato-Nishiuchi, Hitoshi Hasegawa, Leonie K. Ashman, Eric Rubinstein, Maria Yanez-Mo, Francisco Sanchez-Madrid, Kiyotoshi Sekiguchi

BIOCHEMICAL JOURNAL　Vol. 415　No. 3　p. 417-427　2008/11　Research paper (scientific journal)

Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells

Takamichi Miyazaki, Sugiko Futaki, Kouichi Hasegawa, Miwa Kawasaki, Noriko Sanzen, Maria Hayashi, Eihachiro Kawase, Kiyotoshi Sekiguchi, Norio Nakatsuji, Hirofumi Suemori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 375　No. 1　p. 27-32　2008/10　Research paper (scientific journal)

Laminin isoforms containing the γ3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the γ1 and γ2 chains.

Hiroyuki Ido, Shunsuke Ito, Yukimasa Taniguchi, Maria Hayashi, Ryoko Sato-Nishiuchi, Noriko Sanzen, Yoshitaka Hayashi, Sugiko Futaki, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 42　p. 28149-28157　2008/10　Research paper (scientific journal)

Transcriptome-based systematic identification of extracellular matrix proteins

Ri-ichiroh Manabe, Ko Tsutsui, Tomiko Yamada, Mina Kimura, Itsuko Nakano, Chisei Shimono, Noriko Sanzen, Yutaka Furutani, Tomohiko Fukuda, Yasuko Oguri, Keiko Shimamoto, Daiji Kiyozumi, Yuya Sato, Yoshikazu Sado, Haruki Senoo, Shohei Yamashina, Shiro Fukuda, Jun Kawai, Nobuo Sugiura, Koji Kimata, Yoshihide Hayashizaki, Kiyotoshi Sekiguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 105　No. 35　p. 12849-12854　2008/09　Research paper (scientific journal)

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis

Jing Gao, Mindy C. DeRouen, Chih-Hsin Chen, Michael Nguyen, Ngon T. Nguyen, Hiroyuki Ido, Kenji Harada, Kiyotoshi Sekiguchi, Bruce A. Morgan, Jeffery H. Miner, Anthony E. Oro, M. Peter Marinkovich

GENES & DEVELOPMENT　Vol. 22　No. 15　p. 2111-2124　2008/08　Research paper (scientific journal)

The tetraspanin CD151 regulates cell morphology and intracellular signaling on laminin-511

Masashi Yamada, Yasuhiro Sumida, Akemi Fujibayashi, Kiyomitsu Fukaguchi, Noriko Sanzen, Ryoko Nishiuchi, Kiyotoshi Sekiguchi

FEBS JOURNAL　Vol. 275　No. 13　p. 3335-3351　2008/07　Research paper (scientific journal)

Blood vessels of human islets of Langerhans are surrounded by a double basement membrane

I. Virtanen, M. Banerjee, J. Palgi, O. Korsgren, A. Lukinius, L. -E. Thornell, Y. Kikkawa, K. Sekiguchi, M. Hukkanen, Y. T. Konttinen, T. Otonkoski

DIABETOLOGIA　Vol. 51　No. 7　p. 1181-1191　2008/07　Research paper (scientific journal)

Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes

Kohei Torikai, Yoichi Otsuka, Makoto Nishimura, Megumi Sumida, Tomoji Kawai, Kiyotoshi Sekiguchi, Ikuo Ueda

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 10　p. 5441-5451　2008/05　Research paper (scientific journal)

Laminin-511 is an early epithelial message promoting dermal papilla development and function during early hair morphogenesis

J. Gao, M. DeRouen, C. Chen, M. Nguyen, N. Nguyen, H. Ido, K. Harada, K. Sekiguchi, B. Morgan, J. Miner, A. Oro, P. Marinkovich

JOURNAL OF INVESTIGATIVE DERMATOLOGY　Vol. 128　No. 15　p. S156-S156　2008/04　Research paper (scientific journal)

Characterization of laminin isoforms in human amnion

Seiji Takashima, Masanori Yasuo, Noriko Sanzen, Kiyotoshi Sekiguchi, Motonori Okabe, Toshiko Yoshida, Ayaka Toda, Toshio Nikaido

TISSUE & CELL　Vol. 40　No. 2　p. 75-81　2008/04　Research paper (scientific journal)

Human RME-8 Is Involved in Membrane Trafficking through Early Endosomes

Akemi Fujibayashi, Tomohiko Taguchi, Ryo Misaki, Masashi Ohtani, Naoshi Dohmae, Koji Takio, Masashi Yamada, Jianguo Gu, Megumi Yamakami, Mitsunori Fukuda, Satoshi Waguri, Yasuo Uchiyama, Tamotsu Yoshimori, Kiyotoshi Sekiguchi

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 35-50　2008　Research paper (scientific journal)

Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes

Hironobu Fujiwara, Yoshitaka Hayashi, Noriko Sanzen, Reiko Kobayashi, Charles N. Weber, Tomomi Emoto, Sugiko Futaki, Hitoshi Niwa, Patricia Murray, David Edgar, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 40　p. 29701-29711　2007/10　Research paper (scientific journal)

Lutheran blood group antigen as a receptor for alpha 5 laminins in gingival epithelia

Jaana Willberg, Marketta Hormia, Minna Takkunen, Yamato Kikkawa, Kiyotoshi Sekiguchi, Ismo Virtanen

JOURNAL OF PERIODONTOLOGY　Vol. 78　No. 9　p. 1810-1818　2007/09　Research paper (scientific journal)

Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1

Daiji Kiyozumi, Nagisa Sugimoto, Itsuko Nakano, Kiyotoshi Sekiguchi

MATRIX BIOLOGY　Vol. 26　No. 6　p. 456-462　2007/07　Research paper (scientific journal)

The requirement of the glutamic acid residue at the third position from the carboxyl termini of the laminin gamma chains in integrin binding by laminins

Hiroyuki Ido, Aya Nakamura, Reiko Kobayashi, Shunsuke Ito, Shaoliang Li, Sugiko Futaki, Kiyotoshi Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 15　p. 11144-11154　2007/04　Research paper (scientific journal)

Anti-annexin A2 IgM antibody in preterm infants: Its association with chorioamnionitis

Fumihiko Namba, Hiroyuki Kitajima, Atsushi Tabata, Masahiro Nakayama, Noriyuki Suehara, Katsura Matsunami, Keiko Yanagihara, Masahiro Nishihara, Akihiro Morita, Minoru Yamada, Akihito Kimoto, Shinya Hirano, Kiyotoshi Sekiguchi, Masanor Fujimura, Itaru Yanagihara

PEDIATRIC RESEARCH　Vol. 60　No. 6　p. 699-704　2006/12　Research paper (scientific journal)

The Sp family of transcription factors regulates the human laminin alpha 1 gene in JAR choriocarcinoma cells

Tomoaki Niimi, Yoshitaka Hayashi, Kiyotoshi Sekiguchi, Yasuo Kitagawa

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION　Vol. 1759　No. 11-12　p. 573-579　2006/11　Research paper (scientific journal)

Extracellular matrix of the human cyclic corpus luteum

Helen F. Irving-Rodgers, Barbro E. Friden, Stephanie E. Morris, Helen D. Mason, Mats Brannstrom, Kiyotoshi Sekiguchi, Noriko Sanzen, Lydia M. Sorokin, Yoshikazu Sado, Yoshifumi Ninomiya, Raymond J. Rodgers

MOLECULAR HUMAN REPRODUCTION　Vol. 12　No. 9　p. 525-534　2006/09　Research paper (scientific journal)

Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects

Daiji Kiyozumi, Nagisa Sugimoto, Kiyotoshi Sekiguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 103　No. 32　p. 11981-11986　2006/08　Research paper (scientific journal)

Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11

EL McDearmon, AC Combs, K Sekiguchi, H Fujiwara, JM Ervasti

FEBS LETTERS　Vol. 580　No. 14　p. 3381-3385　2006/06　Research paper (scientific journal)

Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin-integrin interactions using recombinant alpha 3 beta 1, alpha 6 beta 1, alpha 7 beta 1 and alpha 6 beta 4 integrins

R Nishiuchi, J Takagi, M Hayashi, H Ido, Y Yagi, N Sanzen, T Tsuji, M Yamada, K Sekiguchi

MATRIX BIOLOGY　Vol. 25　No. 3　p. 189-197　2006/04　Research paper (scientific journal)

A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells

Yoshitaka Hayashi, Charles N. Weber, Tomomi Emoto, Hironobu Fujiwara, Noriko Sanzen, Sugiko Futaki, Kiyotoshi Sekiguchi

Matrix Biology　Vol. 25　No. 2　p. 85-88　2006/03　Research paper (scientific journal)

Probing the integrin-binding site within the globular domain of laminin-511 with the function-blocking monoclonal antibody 4C7

H Ido, K Harada, Y Yagi, K Sekiguchi

MATRIX BIOLOGY　Vol. 25　No. 2　p. 112-117　2006/03　Research paper (scientific journal)

Downregulation of laminin α4 chain expression inhibits glioma invasion in vitro and in vivo

Shigeyuki Nagato, Kou Nakagawa, Hironobu Harada, Shohei Kohno, Hironobu Fujiwara, Kiyotoshi Sekiguchi, Shiro Ohue, Shinji Iwata, Takanori Ohnishi

International Journal of Cancer　Vol. 117　No. 1　p. 41-50　2005/10/20　Research paper (scientific journal)

Identification and characterization of photomedins: Novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity

Yutaka Furutani, Ri-Ichiroh Manabe, Ko Tsutsui, Tomiko Yamada, Nagisa Sugimoto, Shiro Fukuda, Jun Kawai, Nobuo Sugiura, Koji Kimata, Yoshihide Hayashizaki, Kiyotoshi Sekiguchi

Biochemical Journal　Vol. 389　No. 3　p. 675-684　2005/08/01　Research paper (scientific journal)

A simplified laminin nomenclature

M Aumailley, L Bruckner-Tuderman, WG Carter, R Deutzmann, D Edgar, P Ekblom, J Engel, E Engvall, E Hohenester, JCR Jones, HK Kleinman, MP Marinkovich, GR Martin, U Mayer, G Meneguzzi, JH Miner, K Miyazaki, M Patarroyo, M Paulsson, Quaranta, V, Sanes, JR, T Sasaki, K Sekiguchi, LM Sorokin, JF Talts, K Tryggvason, J Uitto, Virtanen, I, K von der Mark, UM Wewer, Y Yamada, PD Yurchenco

MATRIX BIOLOGY　Vol. 24　No. 5　p. 326-332　2005/08

Laminin gamma 2-chain fragment circulating level increases in patients with metastatic pancreatic ductal cell adenocarcinomas

M Katayama, A Funakoshi, T Sumii, N Sanzen, K Sekiguchi

CANCER LETTERS　Vol. 225　No. 1　p. 167-176　2005/07　Research paper (scientific journal)

Electron tomography reveals diverse conformations of integrin αIIbβ3 in the active state

Kenji Iwasaki, Kaoru Mitsuoka, Yoshinori Fujiyoshi, Yukio Fujisawa, Masakazu Kikuchi, Kiyotoshi Sekiguchi, Takao Yamada

Journal of Structural Biology　Vol. 150　No. 3　p. 259-267　2005/06　Research paper (scientific journal)

Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle

D Kiyozumi, A Osada, N Sugimoto, CN Weber, Y Ono, T Imai, A Okada, K Sekiguchi

EXPERIMENTAL CELL RESEARCH　Vol. 306　No. 1　p. 9-23　2005/05　Research paper (scientific journal)

Potentiation of the ligand-binding activity of integrin alpha 3 beta 1 via association with tetraspanin CD151

R Nishiuchi, N Sanzen, S Nada, Y Sumida, Y Wada, M Okada, J Takagi, H Hasegawa, K Sekiguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 102　No. 6　p. 1939-1944　2005/02　Research paper (scientific journal)

Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis

A Osada, D Kiyozumi, K Tsutsui, Y Ono, CN Weber, N Sugimoto, T Imai, A Okada, K Sekiguchi

EXPERIMENTAL CELL RESEARCH　Vol. 303　No. 1　p. 148-159　2005/02　Research paper (scientific journal)

Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes cancer cell migration

Elisabeth L. Bair, Ling Chen Man, Kathy McDaniel, Kiyotoshi Sekiguchi, Anne E. Cress, Raymond B. Nagle, George Timothy Bowden

Neoplasia　Vol. 7　No. 4　p. 380-389　2005　Research paper (scientific journal)

Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression

S Futaki, Y Hayashi, T Emoto, CN Weber, K Sekiguchi

MOLECULAR AND CELLULAR BIOLOGY　Vol. 24　No. 23　p. 10492-10503　2004/12　Research paper (scientific journal)

Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis

S Astrof, D Crowley, EL George, T Fukuda, K Sekiguchi, D Hanahan, RO Hynes

MOLECULAR AND CELLULAR BIOLOGY　Vol. 24　No. 19　p. 8662-8670　2004/10　Research paper (scientific journal)

Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta 1 integrin-null cells

Y Kikkawa, H Yu, E Genersch, N Sanzen, K Sekiguchi, R Fassler, KP Campbell, JF Talts, P Ekblom

EXPERIMENTAL CELL RESEARCH　Vol. 300　No. 1　p. 94-108　2004/10　Research paper (scientific journal)

SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha 1 gene

T Niimi, Y Hayashi, S Futaki, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 36　p. 38055-38061　2004/09　Research paper (scientific journal)

Association between laminin-8 and glial tumor grade, recurrence, and patient survival

JY Ljubimova, M Fugita, NM Khazenzon, A Das, BB Pikul, D Newman, K Sekiguchi, LM Sorokin, T Sasaki, KL Black

CANCER　Vol. 101　No. 3　p. 604-612　2004/08　Research paper (scientific journal)

Differential regulation of focal adhesion kinase and paxillin phosphorylation by the small GTP-binding protein rho in human corneal epithelial cells

J Saito, N Morishige, TI Chikama, JG Gu, K Sekiguchi, T Nishida

JAPANESE JOURNAL OF OPHTHALMOLOGY　Vol. 48　No. 3　p. 199-207　2004/05　Research paper (scientific journal)

Introduction of bisecting GlcNAc into integrin alpha(5)beta(1) reduces ligand binding and down-regulates cell adhesion and cell migration

T Isaji, JG Gu, R Nishiuchi, YY Zhao, M Takahashi, E Miyoshi, K Honke, K Sekiguchi, N Taniguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 19　p. 19747-19754　2004/05　Research paper (scientific journal)

Establishment and characterization of a parietal endoderm-like cell line derived from Engelbreth-Holm-Swarm tumor (EHSPEL), a possible resource for an engineered basement membrane matrix

Y Hayashi, T Emoto, S Futaki, K Sekiguchi

MATRIX BIOLOGY　Vol. 23　No. 1　p. 47-62　2004/04　Research paper (scientific journal)

Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10

H Ido, K Harada, S Futaki, Y Hayashi, R Nishiuchi, Y Natsuka, SL Li, Y Wada, AC Combs, JM Ervasti, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 12　p. 10946-10954　2004/03　Research paper (scientific journal)

Laminin-5 in epithelial tumour invasion

M Katayama, K Sekiguchi

JOURNAL OF MOLECULAR HISTOLOGY　Vol. 35　No. 3　p. 277-286　2004/03

Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8

H Fujiwara, JG Gu, K Sekiguchi

EXPERIMENTAL CELL RESEARCH　Vol. 292　No. 1　p. 67-77　2004/01　Research paper (scientific journal)

Molecular basis of constitutive production of basement membrane components - Gene expression profiles of Engelbreth-Holm-Swarm tumor and F9 embryonal carcinoma cells

S Futaki, Y Hayashi, M Yamashita, K Yagi, H Bono, Y Hayashizaki, Y Okazaki, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 50　p. 50691-50701　2003/12　Research paper (scientific journal)

Recombinant expression and characterization of a novel fibronectin isoform expressed in cartilaginous tissues

T Kozaki, Y Matsui, JG Gu, R Nishiuchi, N Sugiura, K Kimata, K Ozono, H Yoshikawa, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 50　p. 50546-50553　2003/12　Research paper (scientific journal)

Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro

Natalya M. Khazenzon, Alexander V. Ljubimov, Alexander J. Lakhter, Manabu Fujita, Hironobu Fujiwara, Kiyotoshi Sekiguchi, Lydia M. Sorokin, Noora Petaj̈äniemi, Ismo Virtanen, Keith L. Black, Julia Y. Ljubimova

Molecular Cancer Therapeutics　Vol. 2　No. 10　p. 985-994　2003/10　Research paper (scientific journal)

CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization

M Shigeta, N Sanzen, M Ozawa, JG Gu, H Hasegawa, K Sekiguchi

JOURNAL OF CELL BIOLOGY　Vol. 163　No. 1　p. 165-176　2003/10　Research paper (scientific journal)

A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines

Daisuke Nagakubo, Toshiyuki Murai, Toshiyuki Tanaka, Takeo Usui, Masanori Matsumoto, Kiyotoshi Sekiguchi, Masayuki Miyasaka

Journal of Immunology　Vol. 171　No. 2　p. 553-561　2003/07/15　Research paper (scientific journal)

Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways

Gu, J, Fujibayashi, A, Yamada, K.M, Sekiguchi, K

J. Biol. Chem.　Vol. 277　No. 22　p. 19922-19928　2003/04　Research paper (scientific journal)

Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt

JG Gu, S Nada, M Okada, K Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 303　No. 3　p. 973-977　2003/04　Research paper (scientific journal)

Characterization of the ligand binding specificities of integrin α3β1 and α6β1 using a panel of purified laminin isoforms containing distinct α chains.

Nishiuchi, R, Murayama, O, Fujiwara, H, Gu, J, Kawakami T, Aimoto, S, Wada, Y, Sekiguchi, K

J. Biochem.　Vol. 134　No. 4　p. 497-504　2003/04　Research paper (scientific journal)

Identification of an upstream enhancer in the mouse laminin alpha 1 gene defining its high level of expression in parietal endoderm cells

T Niimi, Y Hayashi, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 11　p. 9332-9338　2003/03　Research paper (scientific journal)

Laminin expression patterns in human ureteral tissue

Kazunori Hattori, Reiko Mabuchi, Hironobu Fujiwara, Noriko Sanzen, Kiyotoshi Sekiguchi, Koji Kawai, Hideyuki Akaza

Journal of Urology　Vol. 170　No. 5　p. 2040-2043　2003　Research paper (scientific journal)

Laminin gamma 2-chain fragment in the circulation: A prognostic indicator of epithelial tumor invasion

M Katayama, N Sanzen, A Funakoshi, K Sekiguchi

CANCER RESEARCH　Vol. 63　No. 1　p. 222-229　2003/01　Research paper (scientific journal)

Identification and recombinant production of human laminin alpha 4 subunit splice variants

Y Hayashi, KH Kim, H Fujiwara, C Shimono, M Yamashita, N Sanzen, S Futaki, K Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 299　No. 3　p. 498-504　2002/12　Research paper (scientific journal)

Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro

T Fukuda, N Yoshida, Y Kataoka, R Manabe, Y Mizuno-Horikawa, M Sato, K Kuriyama, N Yasui, K Sekiguchi

CANCER RESEARCH　Vol. 62　No. 19　p. 5603-5610　2002/10　Research paper (scientific journal)

Localization of laminin alpha 4-chain in developing and adult human tissues

N Petajaniemi, M Korhonen, J Kortesmaa, K Tryggvason, K Sekiguchi, H Fujiwara, L Sorokin, LE Thornell, Z Wondimu, D Assefa, M Patarroyo, Virtanen, I

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY　Vol. 50　No. 8　p. 1113-1130　2002/08　Research paper (scientific journal)

Matrix metalloproteinase-2 is involved in A549 cell migration on laminin-10/11

J Gu, R Nishiuchi, K Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 296　No. 1　p. 73-77　2002/08　Research paper (scientific journal)

Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways

JG Gu, A Fujibayashi, KM Yamada, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 22　p. 19922-19928　2002/05　Research paper (scientific journal)

Laminin-10/11 and fibronectin differentially regulate integrin-dependent rho and rac activation via p130(Cas)-CrkII-DOCK180 pathway

JG Gu, Y Sumida, N Sanzen, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 29　p. 27090-27097　2001/07　Research paper (scientific journal)

Purification and characterization of human laminin-8 - Laminin-8 stimulates cell adhesion and migration through alpha(3)beta(1) and alpha(6)beta(1) integrins

H Fujiwara, Y Kikkawa, N Sanzen, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 20　p. 17550-17558　2001/05　Research paper (scientific journal)

Alternative splicing of fibronectin transcripts in osteochondrogenic tumors

Y Matsui, K Nakata, N Araki, K Ozono, Y Fujita, N Tsumaki, H Kawabata, N Yasui, K Sekiguchi, H Yoshikawa

ANTICANCER RESEARCH　Vol. 21　No. 2A　p. 1103-1106　2001/03　Research paper (scientific journal)

Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis

R Fleischmajer, K Kuroda, A Utani, ED MacDonald, JS Perlish, E Arikawa-Hirasawa, K Sekiguchi, N Sanzen, R Timpl, Y Yamada

MATRIX BIOLOGY　Vol. 19　No. 7　p. 637-647　2000/12　Research paper (scientific journal)

Integrin binding specificity of laminin-10/11 : laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins

Y Kikkawa, N Sanzen, H Fujiwara, A Sonnenberg, K Sekiguchi

JOURNAL OF CELL SCIENCE　Vol. 113　No. 5　p. 869-876　2000/03　Research paper (scientific journal)

Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: An in vivo and in vitro study

Sohei Satoi, Hiroaki Kitade, Yoshifumi Hiramatsu, A-Hon Kwon, Hakuo Takahashi, Kiyotoshi Sekiguchi, Masanori Uehara, Michio Oda, Yasuaki Yanagimoto, Keiichi Miyashita, Eiji Sakashita, Yasuo Kamiyama

Shock　Vol. 13　No. 6　p. 492-496　2000　Research paper (scientific journal)

Alternatively spliced EDA segment regulates fibronectin-dependent cell cycle progression and mitogenic signal transduction

R Manabe, N Oh-e, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 9　p. 5919-5924　1999/02　Research paper (scientific journal)

Decreased fibronectin expression in Met/HGF-mediated tumorigenesis

Gregory A. Taylor, Mike Jeffers, Craig P. Webb, Han-Mo Koo, Miriam Anver, Kiyotoshi Sekiguchi, George F. Vande Woude

Oncogene　Vol. 17　No. 9　p. 1179-1183　1998/09/03　Research paper (scientific journal)

Isolation and characterization of laminin-10/11 secreted by human lung carcinoma cells - Laminin-10/11 mediates cell adhesion through integrin alpha 3 beta 1

Y Kikkawa, N Sanzen, K Sekiguchi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 273　No. 25　p. 15854-15859　1998/06　Research paper (scientific journal)

Integrin alpha 3 beta 1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells

Y Fukushima, T Ohnishi, N Arita, T Hayakawa, K Sekiguchi

INTERNATIONAL JOURNAL OF CANCER　Vol. 76　No. 1　p. 63-72　1998/03　Research paper (scientific journal)

Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment

R Manabe, N Ohe, T Maeda, T Fukuda, K Sekiguchi

JOURNAL OF CELL BIOLOGY　Vol. 139　No. 1　p. 295-307　1997/10　Research paper (scientific journal)

Loss of EDB+ fibronectin isoform is associated with differentiation of alveolar epithelial cells in human fetal lung

H Arai, H Hirano, S Mushiake, M Nakayama, G Takada, K Sekiguchi

AMERICAN JOURNAL OF PATHOLOGY　Vol. 151　No. 2　p. 403-412　1997/08　Research paper (scientific journal)

Paxillin association in vitro with integrin cytoplasmic domain peptides

Toshiki Tanaka, Ryuji Yamaguchi, Hisataka Sabe, Kiyotoshi Sekiguchi, Judith M. Healy

FEBS Letters　Vol. 399　No. 1-2　p. 53-58　1996/12/09　Research paper (scientific journal)

Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin

H Akamatsu, K IchiharaTanaka, K Ozone, W Kamiike, H Matsuda, K Sekiguchi

CANCER RESEARCH　Vol. 56　No. 19　p. 4541-4546　1996/10　Research paper (scientific journal)

Novel peptide ligands for integrin alpha 6 beta 1 selected from a phage display library

O Murayama, H Nishida, K Sekiguchi

JOURNAL OF BIOCHEMISTRY　Vol. 120　No. 2　p. 445-451　1996/08　Research paper (scientific journal)

Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin alpha 6 subunit expression

H Yamamoto, A Irie, Y Fukushima, T Ohnishi, N Arita, T Hayakawa, K Sekiguchi

INTERNATIONAL JOURNAL OF CANCER　Vol. 65　No. 4　p. 519-524　1996/02　Research paper (scientific journal)

Distinct structural requirements for interaction of the integrins α5β1, αvβ5, and αvβ6 with the central cell binding domain in fibronectin

John Chen, Toshinaga Maeda, Kiyotoshi Sekiguchi, Dean Sheppard

Cell Communication and Adhesion　Vol. 4　No. 4-5　p. 237-250　1996　Research paper (scientific journal)

Adherence of synovial cells on EDA-containing fibronectin

Kazuo Hino, Toshinaga Maeda, Kiyotoshi Sekiguchi, Kazuko Shiozawa, Hisanobu Hirano, Eiji Sakashita, Shunichi Shiozawa

Arthritis and Rheumatism　Vol. 39　No. 10　p. 1685-1692　1996　Research paper (scientific journal)

UP-REGULATION OF INTEGRIN ALPHA-5-BETA-1 EXPRESSION BY INTERLEUKIN-6 IN RABBIT CORNEAL EPITHELIAL-CELLS

H OHASHI, T MAEDA, H MISHIMA, T OTORI, T NISHIDA, K SEKIGUCHI

EXPERIMENTAL CELL RESEARCH　Vol. 218　No. 2　p. 418-423　1995/06　Research paper (scientific journal)

PEPTIDE LIGANDS FOR INTEGRIN ALPHA(V)BETA(3) SELECTED FROM RANDOM PHAGE DISPLAY LIBRARIES

JM HEALY, O MURAYAMA, T MAEDA, K YOSHINO, K SEKIGUCHI, M KIKUCHI

BIOCHEMISTRY　Vol. 34　No. 12　p. 3948-3955　1995/03　Research paper (scientific journal)

ROLE OF THE CARBOXYL-TERMINAL FIB2 DOMAIN IN FIBRONECTIN MATRIX ASSEMBLY

K ICHIHARATANAKA, K TITANI, K SEKIGUCHI

JOURNAL OF CELL SCIENCE　Vol. 108　No. 3　p. 907-915　1995/03　Research paper (scientific journal)

TARGETING OF THE IMMUNOGLOBULIN-BINDING DOMAIN OF PROTEIN-A TO THE EXTRACELLULAR-MATRIX USING A MINIFIBRONECTIN EXPRESSION VECTOR

S MATSUYAMA, K ICHIHARATANAKA, K SEKIGUCHI

JOURNAL OF BIOCHEMISTRY　Vol. 116　No. 4　p. 898-904　1994/10　Research paper (scientific journal)

SITE-SPECIFIC O-GLYCOSYLATION OF CELL ADHESIVE LYSOZYME IN YEAST

T YAMADA, A UYEDA, M OTSU, M MATSUSHIMA, K SEKIGUCHI, M KIKUCHI

BIOCHEMISTRY　Vol. 33　No. 13　p. 3885-3889　1994/04　Research paper (scientific journal)

CELL-ADHESIVE ACTIVITY AND RECEPTOR-BINDING SPECIFICITY OF THE LAMININ-DERIVED YIGSR SEQUENCE GRAFTED ONTO STAPHYLOCOCCAL PROTEIN-A

T MAEDA, K TITANI, K SEKIGUCHI

JOURNAL OF BIOCHEMISTRY　Vol. 115　No. 2　p. 182-189　1994/02　Research paper (scientific journal)

STRUCTURAL AND FUNCTIONAL ANALYSES OF THE ARG-GLY-ASP SEQUENCE INTRODUCED INTO HUMAN LYSOZYME

T YAMADA, M MATSUSHIMA, K INAKA, T OHKUBO, A UYEDA, T MAEDA, K TITANI, K SEKIGUCHI, M KIKUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 268　No. 14　p. 10588-10592　1993/05　Research paper (scientific journal)

COORDINATE ONCODEVELOPMENTAL MODULATION OF ALTERNATIVE SPLICING OF FIBRONECTIN PREMESSENGER RNA AT ED-A, ED-B, AND CS1 REGIONS IN HUMAN LIVER-TUMORS

F OYAMA, S HIROHASHI, M SAKAMOTO, K TITANI, K SEKIGUCHI

CANCER RESEARCH　Vol. 53　No. 9　p. 2005-2011　1993/05　Research paper (scientific journal)

An Amino-Terminal Fibronectin Fragment Stimulates the Differentiation of ST-13 Preadipocytes

Fumio Fukai, Takako Iso, Kiyotoshi Sekiguchi, Norifumi Miyatake, Akira Tsugita, Takashi Katayama

Biochemistry　Vol. 32　No. 22　p. 5746-5751　1993　Research paper (scientific journal)

ENGINEERING OF ARTIFICIAL CELL-ADHESIVE PROTEINS BY GRAFTING EILDVPST SEQUENCE DERIVED FROM FIBRONECTIN

T MAEDA, R OYAMA, K TITANI, K SEKIGUCHI

JOURNAL OF BIOCHEMISTRY　Vol. 113　No. 1　p. 29-35　1993/01　Research paper (scientific journal)

ENGINEERING OF ARTIFICIAL CELL-ADHESION PROTEINS BY GRAFTING THE ARG-GLY-ASP CELL ADHESIVE SIGNAL TO A CALPASTATIN SEGMENT

K HASHINO, T SHIMOJO, F KIMIZUKA, KATO, I, T MAEDA, K SEKIGUCHI, K TITANI

JOURNAL OF BIOCHEMISTRY　Vol. 112　No. 4　p. 547-551　1992/10　Research paper (scientific journal)

MATRIX ASSEMBLY OF RECOMBINANT FIBRONECTIN POLYPEPTIDE CONSISTING OF AMINO-TERMINAL 70-KDA AND CARBOXYL-TERMINAL 37-KDA REGIONS

K ICHIHARATANAKA, T MAEDA, K TITANI, K SEKIGUCHI

FEBS LETTERS　Vol. 299　No. 2　p. 155-158　1992/03　Research paper (scientific journal)

ARTIFICIAL CELL ADHESIVE PROTEINS ENGINEERED BY GRAFTING THE ARG-GLY-ASP CELL RECOGNITION SIGNAL - FACTORS MODULATING THE CELL ADHESIVE ACTIVITY OF THE GRAFTED SIGNAL

T MAEDA, K HASHINO, R OYAMA, K TITANI, K SEKIGUCHI

JOURNAL OF BIOCHEMISTRY　Vol. 110　No. 3　p. 381-387　1991/09　Research paper (scientific journal)

QUALITATIVE AND QUANTITATIVE CHANGES OF HUMAN TENASCIN EXPRESSION IN TRANSFORMED LUNG FIBROBLAST AND LUNG-TUMOR TISSUES - COMPARISON WITH FIBRONECTIN

F OYAMA, S HIROHASHI, Y SHIMOSATO, K TITANI, K SEKIGUCHI

CANCER RESEARCH　Vol. 51　No. 18　p. 4876-4881　1991/09　Research paper (scientific journal)

PRODUCTION AND CHARACTERIZATION OF FUNCTIONAL DOMAINS OF HUMAN FIBRONECTIN EXPRESSED IN ESCHERICHIA-COLI

F KIMIZUKA, Y TAGUCHI, Y OHDATE, Y KAWASE, T SHIMOJO, K HASHINO, KATO, I, K SEKIGUCHI, K TITANI

JOURNAL OF BIOCHEMISTRY　Vol. 110　No. 2　p. 284-291　1991/08　Research paper (scientific journal)

ROLE OF TYPE-III HOMOLOGY REPEATS IN CELL ADHESIVE FUNCTION WITHIN THE CELL-BINDING DOMAIN OF FIBRONECTIN

F KIMIZUKA, Y OHDATE, Y KAWASE, T SHIMOJO, Y TAGUCHI, K HASHINO, S GOTO, H HASHI, KATO, I, K SEKIGUCHI, K TITANI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 266　No. 5　p. 3045-3051　1991/02　Research paper (scientific journal)

ONCODEVELOPMENTAL REGULATION OF THE ALTERNATIVE SPLICING OF FIBRONECTIN PRE-MESSENGER-RNA IN HUMAN LUNG TISSUES

F OYAMA, S HIROHASHI, Y SHIMOSATO, K TITANI, K SEKIGUCHI

CANCER RESEARCH　Vol. 50　No. 4　p. 1075-1078　1990/02　Research paper (scientific journal)

RECOMBINANT CARBOXYL-TERMINAL FIBRIN-BINDING DOMAIN OF HUMAN FIBRONECTIN EXPRESSED IN MOUSE L-CELLS

K ICHIHARATANAKA, K TITANI, K SEKIGUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 265　No. 1　p. 401-407　1990/01　Research paper (scientific journal)

A NOVEL CELL ADHESIVE PROTEIN ENGINEERED BY INSERTION OF THE ARG-GLY-ASP-SER TETRAPEPTIDE

T MAEDA, R OYAMA, K ICHIHARATANAKA, F KIMIZUKA, KATO, I, K TITANI, K SEKIGUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 264　No. 26　p. 15165-15168　1989/09　Research paper (scientific journal)

DEREGULATION OF ALTERNATIVE SPLICING OF FIBRONECTIN PRE MESSENGER-RNA IN MALIGNANT HUMAN-LIVER TUMORS

F OYAMA, S HIROHASHI, Y SHIMOSATO, K TITANI, K SEKIGUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 264　No. 18　p. 10331-10334　1989/06　Research paper (scientific journal)

PROBING MOLECULAR POLYMORPHISM OF FIBRONECTINS WITH ANTIBODIES DIRECTED TO THE ALTERNATIVELY SPLICED PEPTIDE SEGMENTS

K SEKIGUCHI, K TITANI

BIOCHEMISTRY　Vol. 28　No. 8　p. 3293-3298　1989/04　Research paper (scientific journal)

PATTERNS OF ALTERNATIVE SPLICING OF FIBRONECTIN PRE-MESSENGER RNA IN HUMAN ADULT AND FETAL TISSUES

F OYAMA, Y MURATA, N SUGANUMA, T KIMURA, K TITANI, K SEKIGUCHI

BIOCHEMISTRY　Vol. 28　No. 3　p. 1428-1434　1989/02　Research paper (scientific journal)

HUMAN-TISSUE FIBRONECTIN - EXPRESSION OF DIFFERENT ISOTYPES IN THE ADULT AND FETAL TISSUES

K SEKIGUCHI, AM KLOS, S HIROHASHI, S HAKOMORI

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 141　No. 3　p. 1012-1017　1986/12　Research paper (scientific journal)

HUMAN-LIVER FIBRONECTIN COMPLEMENTARY DNAS - IDENTIFICATION OF 2 DIFFERENT MESSENGER-RNAS POSSIBLY ENCODING THE ALPHA-SUBUNIT AND BETA-SUBUNIT OF PLASMA FIBRONECTIN

K SEKIGUCHI, AM KLOS, K KURACHI, S YOSHITAKE, SI HAKOMORI

BIOCHEMISTRY　Vol. 25　No. 17　p. 4936-4941　1986/08　Research paper (scientific journal)

DIFFERENCES IN DOMAIN-STRUCTURE BETWEEN HUMAN FIBRONECTINS ISOLATED FROM PLASMA AND FROM CULTURE SUPERNATANTS OF NORMAL AND TRANSFORMED FIBROBLASTS - STUDIES WITH DOMAIN-SPECIFIC ANTIBODIES

K SEKIGUCHI, A SIRI, L ZARDI, SI HAKOMORI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 260　No. 8　p. 5105-5114　1985　Research paper (scientific journal)

DIFFERENCES IN DOMAIN-STRUCTURE BETWEEN PERICELLULAR MATRIX AND PLASMA FIBRONECTINS AS REVEALED BY DOMAIN-SPECIFIC ANTIBODIES COMBINED WITH LIMITED PROTEOLYSIS AND S-CYANYLATION - A PRELIMINARY NOTE

K SEKIGUCHI, A SIRI, L ZARDI, S HAKOMORI

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 116　No. 2　p. 534-540　1983　Research paper (scientific journal)

DOMAIN-STRUCTURE OF HUMAN-PLASMA FIBRONECTIN - DIFFERENCES AND SIMILARITIES BETWEEN HUMAN AND HAMSTER FIBRONECTINS

K SEKIGUCHI, S HAKOMORI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 258　No. 6　p. 3967-3973　1983　Research paper (scientific journal)

TOPOLOGICAL ARRANGEMENT OF 4 FUNCTIONALLY DISTINCT DOMAINS IN HAMSTER PLASMA FIBRONECTIN - A STUDY WITH COMBINATION OF S-CYANYLATION AND LIMITED PROTEOLYSIS

K SEKIGUCHI, S HAKOMORI

BIOCHEMISTRY　Vol. 22　No. 6　p. 1415-1422　1983　Research paper (scientific journal)

BINDING OF FIBRONECTIN AND ITS PROTEOLYTIC FRAGMENTS TO GLYCOSAMINOGLYCANS - EXPOSURE OF CRYPTIC GLYCOSAMINOGLYCAN-BINDING DOMAINS UPON LIMITED PROTEOLYSIS

K SEKIGUCHI, S HAKOMORI, M FUNAHASHI, MATSUMOTO, I, N SENO

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 258　No. 23　p. 4359-4365　1983　Research paper (scientific journal)

VIRUS-INDUCED FUSION OF HUMAN-ERYTHROCYTE GHOSTS .1. EFFECTS OF MACROMOLECULES ON THE FINAL STAGES OF THE FUSION REACTION

K SEKIGUCHI, K KURODA, SI OHNISHI, A ASANO

BIOCHIMICA ET BIOPHYSICA ACTA　Vol. 645　No. 2　p. 211-225　1981　Research paper (scientific journal)

DOMAIN-STRUCTURE OF HAMSTER PLASMA FIBRONECTIN - ISOLATION AND CHARACTERIZATION OF 4 FUNCTIONALLY DISTINCT DOMAINS AND THEIR UNEQUAL DISTRIBUTION BETWEEN 2 SUBUNIT POLYPEPTIDES

K SEKIGUCHI, M FUKUDA, SI HAKOMORI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 256　No. 12　p. 6452-6462　1981　Research paper (scientific journal)

IDENTIFICATION OF 2 FIBRIN-BINDING DOMAINS IN PLASMA FIBRONECTIN AND UNEQUAL DISTRIBUTION OF THESE DOMAINS IN 2 DIFFERENT SUBUNITS - A PRELIMINARY NOTE

K SEKIGUCHI, S HAKOMORI

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 97　No. 2　p. 709-715　1980　Research paper (scientific journal)

FUNCTIONAL DOMAIN-STRUCTURE OF FIBRONECTIN

K SEKIGUCHI, S HAKOMORI

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES　Vol. 77　No. 5　p. 2661-2665　1980　Research paper (scientific journal)

Participation of spectrin in Sendai virus-induced fusion of human erythrocyte ghosts.

Sekiguchi, K, Asano, A

Proc. Natl. Acad. Sci. USA　Vol. 75　No. 4　p. 1740-1744　1978/04　Research paper (scientific journal)

Effect of colchicine on virus-induced fusion of human erythrocytes.

Sekiguchi, K, Asano, A

Life Sci.　Vol. 18　No. 12　p. 1383-1389　1976/06　Research paper (scientific journal)