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Tanaka Atsushi

田中 淳

Graduate School of Medicine, Specially Appointed Associate Professor (Full Time)

Education

  • - 2009, The University of Chicago,, Committee on Immunology (Ph.D.)

Research History

  • 2021 - Present, Immunology Frontier Research Center, Osaka University, Associate Professor
  • 2021 - Present, Graduate School of Medicine, Osaka University, Associate Professor
  • 2014 - 2021, Immunology Frontier Research Center, Osaka University, Assistant Professor
  • 2014 - 2021, Osaka University, Graduate School of Medicine, Assistant Professor
  • 2011/04 - 2014/03, Institute for Frontier Medical Sciences, Kyoto University, JSPS Postdoctoral Research Fellow
  • 2009/11 - 2011/03, Kyoto University, Institute for Frontier Medical Sciences
  • 2009/03 - 2009/07, Abbott Laboratories, Cancer Research Department,, Abbott Graduate Fellow
  • 2001/05 - 2001/08, American Cancer Society Student Cancer Fellow

Research Areas

  • Life sciences, Tumor diagnostics and therapeutics
  • Life sciences, Immunology

Professional Memberships

  • THE JAPANESE SOCIETY FOR IMMUNOLOGY

Papers

  • Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy, Christopher Tay,Atsushi Tanaka,Shimon Sakaguchi, Cancer Cell, Elsevier BV, Vol. 41, No. 3, p. 450-465, 2023/03
  • Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease, Atsushi Tanaka,Shinji Maeda,Takashi Nomura,Mara Anais Llamas-Covarrubias,Satoshi Tanaka,Lin Jin,Ee Lyn Lim,Hiromasa Morikawa,Yohko Kitagawa,Shuji Akizuki,Yoshinaga Ito,Chihiro Fujimori,Keiji Hirota,Tosei Murase,Motomu Hashimoto,Junichi Higo,Rose Zamoyska,Ryuzo Ueda,Daron M. Standley,Noriko Sakaguchi,Shimon Sakaguchi, Journal of Experimental Medicine, Rockefeller University Press, Vol. 220, No. 2, 2023/02/06
  • PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment, Dean Thumkeo,Siwakorn Punyawatthananukool,Somsak Prasongtanakij,Ryuma Matsuura,Kentaro Arima,Huan Nie,Rie Yamamoto,Naohiro Aoyama,Hisao Hamaguchi,Shingo Sugahara,Shinobu Takeda,Varodom Charoensawan,Atsushi Tanaka,Shimon Sakaguchi,Shuh Narumiya, Cell Reports, Elsevier BV, Vol. 39, No. 10, p. 110914-110914, 2022/06
  • CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory., Yujiro Kidani,Wataru Nogami,Yoshiaki Yasumizu,Atsunari Kawashima,Atsushi Tanaka,Yudai Sonoda,Yumi Tona,Kunitaka Nashiki,Reimi Matsumoto,Masaki Hagiwara,Motonao Osaki,Keiji Dohi,Takayuki Kanazawa,Azumi Ueyama,Mai Yoshikawa,Tetsuya Yoshida,Mitsunobu Matsumoto,Kanji Hojo,Satomi Shinonome,Hiroshi Yoshida,Michinari Hirata,Miya Haruna,Yamami Nakamura,Daisuke Motooka,Daisuke Okuzaki,Yasuko Sugiyama,Makoto Kinoshita,Tatsusada Okuno,Taigo Kato,Koji Hatano,Motohide Uemura,Ryoichi Imamura,Kazunori Yokoi,Atsushi Tanemura,Yasushi Shintani,Tadashi Kimura,Norio Nonomura,Hisashi Wada,Masaki Mori,Yuichiro Doki,Naganari Ohkura,Shimon Sakaguchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 7, 2022/02/15
  • Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases, Naganari Ohkura,Yoshiaki Yasumizu,Yohko Kitagawa,Atsushi Tanaka,Yamami Nakamura,Daisuke Motooka,Shota Nakamura,Yukinori Okada,Shimon Sakaguchi, Immunity, Elsevier BV, Vol. 52, No. 6, p. 1119-1132.e4, 2020/06
  • Regulatory T Cells and Human Disease, Shimon Sakaguchi,Norihisa Mikami,James B. Wing,Atsushi Tanaka,Kenji Ichiyama,Naganari Ohkura, Annual Review of Immunology, Annual Reviews, Vol. 38, No. 1, p. 541-566, 2020/04/26
  • Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells, Atsushi Tanaka,Hiroyoshi Nishikawa,Shinsuke Noguchi,Daisuke Sugiyama,Hiromasa Morikawa,Yoshiko Takeuchi,Danbee Ha,Naoya Shigeta,Toshio Kitawaki,Yuka Maeda,Takuro Saito,Yoshinori Shinohara,Yoshihiro Kameoka,Keiko Iwaisako,Fumihiko Monma,Kohshi Ohishi,Julia Karbach,Elke Jäger,Kenichi Sawada,Naoyuki Katayama,Naoto Takahashi,Shimon Sakaguchi, Journal of Experimental Medicine, Rockefeller University Press, Vol. 217, No. 2, 2020/02/03
  • Targeting Treg cells in cancer immunotherapy, Tanaka A,Sakaguchi S, Eur J Immunol., Vol. 49, No. 8, p. 1140-1146, 2019/08
  • Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer, James B Wing,Atsushi Tanaka,Shimon Sakaguchi, Immunity, Vol. 50, No. 2, p. 302-316, 2019/02
  • Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody, Ha D,Tanaka A,Kibayashi T,Tanemura A,Sugiyama D,Wing JB,Lim EL,Tang K,Adeegbe D,Newell EW,Katayama I,Nishikawa H,Sakaguchi S, Proc. Natl. Acad. Sci. USA, Vol. 116, No. 2, p. 609-618, 2019/01
  • Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis, Keiji Hirota,Motomu Hashimoto,Yoshinaga Ito,Mayumi Matsuura,Hiromu Ito,Masao Tanaka,Hitomi Watanabe,Gen Kondoh,Atsushi Tanaka,Keiko Yasuda,Manfred Kopf,Alexandre J. Potocnik,Brigitta Stockinger,Noriko Sakaguchi,Shimon Sakaguchi, Immunity, Elsevier BV, Vol. 48, No. 6, p. 1220-1232.e5, 2018/06
  • Regulatory T cells in cancer immunotherapy, Atsushi Tanaka,Shimon Sakaguchi, CELL RESEARCH, INST BIOCHEMISTRY & CELL BIOLOGY, Vol. 27, No. 1, p. 109-118, 2017/01
  • Early life Aire, Atsushi Tanaka,Shimon Sakaguchi, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 348, No. 6234, p. 506-507, 2015/05
  • Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax), J. D. Leverson,H. Zhang,J. Chen,S. K. Tahir,D. C. Phillips,J. Xue,P. Nimmer,S. Jin,M. Smith,Y. Xiao,P. Kovar,A. Tanaka,M. Bruncko,G. S. Sheppard,L. Wang,S. Gierke,L. Kategaya,D. J. Anderson,C. Wong,J. Eastham-Anderson,M. J. C. Ludlam,D. Sampath,W. J. Fairbrother,I. Wertz,S. H. Rosenberg,C. Tse,S. W. Elmore,A. J. Souers, CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, Vol. 6, 2015/01
  • Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease, Yoshinaga Ito,Motomu Hashimoto,Keiji Hirota,Naganari Ohkura,Hiromasa Morikawa,Hiroyoshi Nishikawa,Atsushi Tanaka,Moritoshi Furu,Hiromu Ito,Takao Fujii,Takashi Nomura,Sayuri Yamazaki,Akimichi Morita,Dario A. A. Vignali,John W. Kappler,Shuichi Matsuda,Tsuneyo Mimori,Noriko Sakaguchi,Shimon Sakaguchi, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 346, No. 6207, p. 363-368, 2014/10
  • T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development, Naganari Ohkura,Masahide Hamaguchi,Hiromasa Morikawa,Kyoko Sugimura,Atsushi Tanaka,Yoshinaga Ito,Motonao Osaki,Yoshiaki Tanaka,Riu Yamashita,Naoko Nakano,Jochen Huehn,Hans Joerg Fehling,Tim Sparwasser,Kenta Nakai,Shimon Sakaguchi, IMMUNITY, CELL PRESS, Vol. 37, No. 5, p. 785-799, 2012/11
  • Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment, Shimon Sakaguchi,Satoshi Tanaka,Atsushi Tanaka,Yoshinaga Ito,Shinji Maeda,Noriko Sakaguchi,Motomu Hashimoto, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 585, No. 23, p. 3633-3639, 2011/12
  • Attracting AID to targets of somatic hypermutation, Atsushi Tanaka,Hong Ming Shen,Sarayu Ratnam,Prashant Kodgire,Ursula Storb, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 207, No. 2, p. 405-415, 2010/02
  • Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice, Hong Ming Shen,Atsushi Tanaka,Grazyna Bozek,Dan Nicolae,Ursula Storb, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 177, No. 8, p. 5386-5392, 2006/10
  • The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions, Simonne Longerich,Atsushi Tanaka,Grazyna Bozek,Dan Nicolae,Ursula Storb, Journal of Experimental Medicine, Rockefeller University Press, Vol. 202, No. 10, p. 1443-1454, 2005/11/21
  • Melanocyte‐specific <scp>CD49a</scp> <sup>+</sup> <scp>CD8</scp> <sup>+</sup> T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy, Kazunori Yokoi,Rei Watanabe,Miki Kume,Saki Yamane,Atsushi Tanaka,Manabu Fujimoto,Atsushi Tanemura, The Journal of Dermatology, Wiley, 2022/12/14
  • Characterization of human epithelial resident memory regulatory T cells, Takuya Sato,Youichi Ogawa,Kazunori Yokoi,Yuka Nagasaka,Aoha Ishikawa,Ichiro Shiokawa,Manao Kinoshita,Rei Watanabe,Shinji Shimada,Atsushi Tanaka,Akira Momosawa,Tatsuyoshi Kawamura, Frontiers in Immunology, Frontiers Media SA, Vol. 13, p. 962167-962167, 2022/08/19
  • Dynamics of effector and naïve Regulatory T cells throughout pregnancy, Naoya Shigeta,Keiichi Kumasawa,Atsushi Tanaka,James Badger Wing,Hitomi Nakamura,Shimon Sakaguchi,Tadashi Kimura, Journal of Reproductive Immunology, Elsevier BV, Vol. 140, p. 103135-103135, 2020
  • PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer, Takahiro Kamada,Yosuke Togashi,Danbee Ha,Akinori Sasaki,Yoshiaki Nakamura,Eiichi Sato,Shota Fukuoka,Yasuko Tada,Atsushi Tanaka,Akihito Kawazoe,Takahiro Kinoshita,Kohei Shitara,Shimon Sakaguchi,Hiroyoshi Nishikawa, Proc Natl Acad Sci U S A, 2019/04
  • Identification of novel and noninvasive biomarkers of acute cellular rejection after liver transplantation by protein microarray, Okubo, K,Wada, H,Tanaka, A,Eguchi, E,Hamaguchi, M,Tomokuni, A,Tomimaru, Y,Asaoka, T,Hama, N,Kawamoto, K,Kobayashi, S,Marubashi, S,Nagano, H,Sakaguchi, N,Nishikawa, H,Doki, Y,Mori, M,Sakaguchi, S, Transplantation Direct, Vol. 2, No. 12, 2016/11
  • Targeting of AID to Immunoglobulin Genes, Ursula Storb,Hong Ming Shen,Simonne Longerich,Sarayu Ratnam,Atsushi Tanaka,Grazyna Bozek,Serhiy Pylawka, Advances in Experimental Medicine and Biology, Springer US, Vol. 596, p. 83-91, 2007

Misc.

  • エフェクターTregとがん免疫, 田中淳, 臨床免疫・アレルギー科, Vol. 74, No. 1, p. 74-79, 2020/07
  • ヒトFoxP3+制御性T細胞の多様性とその解析, 木林達也,田中淳, 臨床免疫・アレルギー科, Vol. 74, p. 307-313, 2020
  • Treg特異的なTCRシグナルの分子制御と免疫寛容の維持, 田中淳,坂口志文, 臨床免疫・アレルギー科, Vol. 71, p. 497-501, 2019/05
  • Treg分化と機能におけるTCRシグナルの役割, 田中淳, 医学のあゆみ, Vol. 268, No. 13, p. 1086-1090, 2019/03
  • ニボルマブ抵抗性高悪性度腎細胞癌で高発現する制御性T細胞に特異的な分子CCR8を標的とした新規免疫療法の開発, 河嶋 厚成,冨山 栄輔,洪 陽子,松下 慎,中野 剛佑,林 裕次郎,加藤 大悟,波多野 浩士,氏家 剛,植村 元秀,田中 淳,大倉 永也,坂口 志文,和田 尚,野々村 祝夫, 日本癌学会総会記事, (一社)日本癌学会, Vol. 79回, p. OE14-1, 2020/10
  • イマチニブによるエフェクター制御性T細胞の除去と抗腫瘍免疫の活性化, 藤岡優樹,高橋直人,田中淳, 血液内科, Vol. 81, p. 554-561, 2020
  • 制御性T細胞に認められるイントロンRNAの解析, 中村やまみ,安水良明,田中淳,坂口志文,大倉永也, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 42nd, 2019
  • 腫瘍免疫の新しい理解と免疫療法のターゲット, 田中淳,坂口志文, 臨床婦人科産科, Vol. 72, p. 524-529, 2018
  • Tregは本当にがん免疫療法に役立つのか?, 田中淳,坂口志文, 腫瘍内科, Vol. 19, No. 1, p. 41-46, 2017
  • Inflammatory circuit of Th17 cells, fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis, K. Hirota,Y. Ito,M. Hashimoto,H. Watanabe,G. Kondoh,A. Tanaka,K. Yasuda,M. Kopf,A. J. Potocnik,B. Stockinger,N. Sakaguchi,S. Sakaguchi, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 46, p. 29-29, 2016/08
  • 制御性T細胞の同定とその役割, 田中淳,坂口志文, がん分子標的治療, Vol. 13, No. 4, p. 66-70, 2015
  • ZAP-70 anomalies and autoimmunity, Vol. 60, No. 6, p. 693-697, 2013

Publications

  • In Chronic Inflammation: Mechanisms and Regulation, K. Takatsu & M. Miyasaka, ed., Wing, J,Tanaka, A,Sakaguchi, S, Springer, Japan, 2016

Industrial Property Rights

  • 新規抗CCR8抗体, 児玉 舞,高橋 竜也,小野田 順二,今井 直,中村 悦男,古川 健太郎,宮内 継夫,吉田 哲也,柳樂 盛男,大倉 永也,田中 淳,坂口 志文,和田 尚,河嶋 厚成, 特願2020-538152
  • 癌治療用医薬組成物, 吉田哲也、木谷友次朗、松本光史、金沢崇之、東雲里美、北条完二、大倉永也、坂口志文、田中淳、和田尚、河嶋厚成、野々村祝夫, 特願2018-551478
  • 腫瘍免疫又は感染免疫を増強させる免疫増強剤, 西川博嘉,坂口志文,田中淳, 特願2014-146031

Awards

  • Abbott Fellowship, 2009
  • Cancer Research Center Immunology Travel Award, 2008
  • Women’s Board Travel Award, 2008
  • Cancer Research Center Immunology Travel Award, 2007
  • Doolittle-Harrison Fellowship, 2006
  • Laboratory Biology Award, 2002
  • American Cancer Society Student Cancer Fellowship, 2001

Presentations

  • Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells, 田中淳, 第16回麒麟塾, 2021/06/19
  • Tregと腫瘍免疫, 田中淳, Melanoma Conferences, 2020/01/10
  • Cancer immunotherapy targeting regulatory T cells, Atsushi Tanaka, 第78回日本癌学会学術総会, 2019/09
  • Treg-specific control of TCR signaling molecules, Atsushi Tanaka, Keystone Symposia: Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity (B3), 2019/02
  • 制御性T細胞と腫瘍免疫, 田中淳, Immuno-Checkpoint Blockade Seminar in Osaka 2018, 2018/01
  • Treg-specific control of TCR signaling molecules, Atsushi Tanaka, 第46回日本免疫学会総会・学術集会, 2017/12
  • 制御性T細胞の特異的なTCRシグナル制御とその応用, 田中淳, 第16回 LEGEND Seminar 2016, 2016/12
  • Selective control of regulatory T cells through TCR signaling molecule, Atsushi Tanaka, 16th International Congress of Immunology, 2016/08
  • Autoimmune range of T cell receptor signaling, Atsushi Tanaka, Keystone symposia T cells: Regulation and Effector function, 2015/03
  • Breakdown of immune tolerance by quantitative and qualitative alterations of ZAP-70, Atsushi Tanaka, Cold Spring Harbor Laboratory Meeting: Gene Expression and Signaling in the Immune System, 2013/05/31
  • Breakdown of Immune Tolerance by Qualitative and Quantitative Alterations of ZAP-70, Atsushi Tanaka, The University of Chicago, Biological Sciences Cluster Committee on Immunology Seminar, 2013/05
  • Essential Cis-element for Inducing Somatic Hypermutation, Atsushi Tanaka,Hong Ming Shen,Ursula Storb, Cold Spring Harbor Laboratory Meeting: Gene Expression and Signaling in the Immune System, 2008/04/25
  • Effects of E-box Motif on Somatic Hypermutation of Ig Genes, Atsushi Tanaka,Hong Ming Shen,Ursula Storb, Keystone Symposia: Biology of B cells in Health and Disease, 2007/02/10
  • Targeting of Somatic Hypermutation to Immunoglobulin Genes, Atsushi Tanaka,Hong Ming Shen,Ursula Storb, Gordon Research Conference: Mutagenesis, 2006/06
  • Mechanism of Somatic Hypermutation of Ig Genes, Tanaka, A,Shen, H,Longerich, S,Ratnam, S,Storb, U, Keystone Symposia: B cell Development, 2005/03
  • Selective control of regulatory T cells through TCR signaling molecule, 田中淳, 第26回 Kyoto T Cell Conference, 2016/05
  • Breakdown of immune tolerance by quantitative and qualitative alterations of TCR signaling through ZAP-70, Atsushi Tanaka, Annual Meeting of the Japanese Society for Immunology, Chiba., 2013/12/11
  • Breakdown of immune tolerance by quantitative and qualitative alterations of ZAP-70, Atsushi Tanaka, 15th International Congress of Immunology, Milan, Italy., 2013/08/25
  • Spontaneous development of autoimmune arthritis and colitis in ZAC mice, Atsushi Tanaka, Annual Meeting of the Japanese Society for Immunology, Kobe, 2012/12/05
  • A Critical Range of ZAP-70 Produces Immunodeficiency and Autoimmunity, Atsushi Tanaka, 1st IFReC-SIgN Winter School on Advanced Immunology, 2012/01/19
  • A critical range of ZAP-70 produces immunodeficiency and autoimmunity, A critical,range of ZAP,produces immunodeficiency,autoimmunity, 40th Annual Meeting of the Japanese Society for Immunology, Chiba, 2011/11/27
  • A critical range of ZAP-70 produces immunodeficiency and autoimmunity, Atsushi Tanaka, 21st Kyoto T Cell Conference, Kyoto, 2011/06/10
  • Essential cis-element for inducing somatic hypermutation, Atsushi Tanaka,Hong Ming Shen,Ursula Storb, Autumn Immunology Conference, 2008/11
  • Targeting of somatic hypermutation to immunoglobulin genes, Tanaka, A,Longerich, S,Storb, U, Autumn Immunology Conference, 2006/11

Academic Activities

  • 第50回日本免疫学会総会・学術集会, 2022/12/09 -
  • 第47回日本免疫学会学術集会, 2018/12/10 -