顔写真

PHOTO

Keiko TOMINAGA
冨永 恵子
Keiko TOMINAGA
冨永 恵子
Graduate School of Frontier Biosciences　Department of Frontier Biosciences, Associate Professor

keyword Neuroscience in General

Research History 5

  1. 1997/04 - 2002/03
    大阪大学・大学院理学研究科・生物科学専攻・助手

  2. 1995/04 - 1997/03
    Osaka University

  3. 1993/07 - 1995/03
    Tokai University

  4. 1993/04 - 1993/06
    Virgina大時間生物学プロジェクト博士研究員

  5. 2002/04 -
    大阪大学・大学院生命機能研究科・准教授

Education 2

  1. Kyushu University

    - 1993

  2. Kyushu University　School of Pharmaceutical Sciences

    - 1988

Professional Memberships 8

  1. Society for Neuroscience(北米神経科学会）

  2. 日本生理学会

  3. 日本時間生物学会

  4. 日本神経科学学会

  5. 日本薬理学会

  6. Japanese Socieyt for Chronobiology

  7. The Japanese Pharmacological Society

  8. Japan Neurscience Society

Research Areas 2

  1. Life sciences / Basic brain sciences /

  2. Life sciences / Neuroscience - general /

Papers 70

  1. Circadian regulation of maternal and feeding behaviors in lactating mice.

    Atsumi Murakami, Haruo Masai, Koyuki Kawamura, Kanako Matsumoto, Hitoshi Okamura, Keiko Tominaga

    Journal of biological rhythms　Vol. 40　No. 4　p. 365-383　2025/08　Research paper (scientific journal)

  2. An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.

    Yoshiaki Yamaguchi, Yota Maekawa, Kyohei Kabashima, Takanobu Mizuno, Motomi Tainaka, Toru Suzuki, Kumiko Dojo, Takeichiro Tominaga, Sayaka Kuroiwa, Satoru Masubuchi, Masao Doi, Keiko Tominaga, Kazuto Kobayashi, Satoshi Yamagata, Keiichi Itoi, Manabu Abe, William J Schwartz, Kenji Sakimura, Hitoshi Okamura

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 43　2023/10/24　Research paper (scientific journal)

  3. Prolonged Light Exposure Induces Circadian Impairment in Aquaporin-4-Knockout Mice

    Atsumi Murakami, Kouki Tsuji, Minako Isoda, Masahiro Matsuo, Yoichiro Abe, Masato Yasui, Hitoshi Okamura, Keiko Tominaga

    J Biol Rhythms　Vol. 38　No. 2　p. 208-214　2023/01　Research paper (scientific journal)

  4. Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity.

    Kojiro Tsujihana, Kosuke Tanegashima, Yasuko Santo, Hiroyuki Yamada, Sota Akazawa, Ryuta Nakao, Keiko Tominaga, Risa Saito, Yasumasa Nishito, Ryu-Ichiro Hata, Tomonori Nakamura, Iori Murai, Yuka Kono, Maho Sugawa, Miki Tanioka, Gyohei Egawa, Masao Doi, Tadashi Isa, Kenji Kabashima, Takahiko Hara, Hitoshi Okamura

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 25　2022/06/21　Research paper (scientific journal)

  5. A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels.

    Masahiro Matsuo, Kazuyuki Seo, Akiyuki Taruno, Yasutaka Mizoro, Yoshiaki Yamaguchi, Masao Doi, Rhyuta Nakao, Hiroshi Kori, Takaya Abe, Harunori Ohmori, Keiko Tominaga, Hitoshi Okamura

    Cell reports　Vol. 39　No. 8　p. 110844-110844　2022/05/24　Research paper (scientific journal)

  6. Role of α2δ3 in Cellular Synchronization of the Suprachiasmatic Nucleus Under Constant Light Conditions.

    Masahiro Matsuo, Kazuyuki Seo, Naoki Mizuguchi, Fumiyoshi Yamazaki, Shoichi Urabe, Naoto Yamada, Masao Doi, Keiko Tominaga, Hitoshi Okamura

    Neuroscience　Vol. 461　p. 1-10　2021/05/01　Research paper (scientific journal)

  7. Transient appearance of Ca2+ -permeable AMPA receptors is crucial for the production of repetitive LTP-induced synaptic enhancement (RISE) in cultured hippocampal slices.

    Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Yukiko Ueno, Katsuhiro Kawaai, Shinichi Saito, Tomoko Tashiro, Akihiko Ogura

    Hippocampus　Vol. 30　No. 7　p. 763-769　2020/04　Research paper (scientific journal)

  8. An in vitro model system for studying the stress-induced memory disorder.

    Akihiko Ogura, Shinichi Saito, Satoshi Kimura, Keiko Tominaga-Yoshino

    Folia Pharmacol. Jpn.　Vol. 150　No. 5　p. 223-227　2017/11

    Publisher: The Japanese Pharmacological Society

  9. An in vitro reproduction of stress-induced memory defects: Effects of corticoids on dendritic spine dynamics

    Shinichi Saito, Satoshi Kimura, Naoki Adachi, Tadahiro Numakawa, Akihiko Ogura, Keiko Tominaga-Yoshino

    SCIENTIFIC REPORTS　Vol. 6　p. 19287-19287　2016/01　Research paper (scientific journal)

  10. Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment

    Erika Sawano, Kanako Iwatani, Keiko Tominaga-Yoshino, Akihiko Ogura, Tomoko Tashiro

    JOURNAL OF NEUROCHEMISTRY　Vol. 135　No. 2　p. 287-300　2015/10　Research paper (scientific journal)

  11. Dendritic spine dynamics leading to spine elimination after repeated induction of LTD

    Hasegawa S, Sakuragi S, Tominaga-Yoshino K, Ogura A

    Sci Rep　Vol. 5　p. 7707-7707　2015/01　Research paper (scientific journal)

  12. Involvement of TrkB- and p75MNTR -signaling pathways in two contrasting forms of long-lasting synaptic plasticity

    Shigeo Sakuragi, Keiko Tominaga-Yoshino, Akihiko Ogura

    Scientific Reports　Vol. 3　p. 3185-3185　2013/11　Research paper (scientific journal)

  13. 記憶固定のin vitro再現 長期記憶の細胞基盤をめざして：繰り返し依存的なシナプス新生

    冨永(吉野)恵子, 小倉明彦

    日薬理誌　2013/10

  14. Dendritic spine dynamics in synaptogenesis after repeated LTP inductions: Dependence on pre-existing spine density

    Yuki Oe, Keiko Tominaga-Yoshino, Sho Hasegawa, Akihiko Ogura

    Scientific Reports　Vol. 3　p. 1957-1957　2013/06　Research paper (scientific journal)

  15. A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells

    Takeshi Shimada, Yoshihiro Takai, Kikuko Shinohara, Atsushi Yamasaki, Keiko Tominaga-Yoshino, Akihiko Ogura, Akihiro Toi, Kouji Asano, Norihito Shintani, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

    JOURNAL OF NEUROCHEMISTRY　Vol. 122　No. 1　p. 81-93　2012/07　Research paper (scientific journal)

  16. Local Establishment of Repetitive Long-Term Potentiation-Induced Synaptic Enhancement in Cultured Hippocampal Slices With Divided Input Pathways

    Yuki Oe, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 89　No. 9　p. 1419-1430　2011/03　Research paper (scientific journal)

  17. Involvement of the p75(NTR) Signaling Pathway in Persistent Synaptic Suppression Coupled With Synapse Elimination Following Repeated Long-Term Depression Induction

    Yoshihiro Egashira, Tsunehiro Tanaka, Priyanka Soni, Shigeo Sakuragi, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 88　No. 16　p. 3433-3446　2010/12　Research paper (scientific journal)

  18. Analysis of Gene Expression Changes Associated With Long-Lasting Synaptic Enhancement in Hippocampal Slice Cultures After Repetitive Exposures to Glutamate

    Katsuhiro Kawaai, Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Naoko Taniguchi, Yasumitsu Kondoh, Hideo Tashiro, Akihiko Ogura, Tomoko Tashiro

    JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 88　No. 13　p. 2911-2922　2010/06　Research paper (scientific journal)

  19. Persistent Synapse Loss Induced by Repetitive LTD in Developing Rat Hippocampal Neurons

    Yo Shinoda, Tsunehiro Tanaka, Keiko Tominaga-Yoshino, Akihiko Ogura

    PLOS ONE　Vol. 5　No. 4　2010/04　Research paper (scientific journal)

  20. Repetitive induction of late-phase LTP produces long-lasting synaptic enhancement accompanied by synaptogenesis in cultured hippocampal slices

    Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Masayoshi Okada, Hiroko Matsuda, Akihiko Ogura

    HIPPOCAMPUS　Vol. 18　No. 3　p. 281-293　2008　Research paper (scientific journal)

  21. Ultrastructural features of hippocampal CA1 synapses with respect to synaptic enhancement following repeated PKA activation.

    Urakubo,T, Ogura,A, Tominaga-Yoshino,K

    Neurosci. Lett.　Vol. 407　No. 1　p. 1-5　2006/10　Research paper (scientific journal)

  22. Possible involvement of BDNF release in long-lasting synapse formation induced by repetitive PKA activation

    Naoko Taniguchi, Yo Shinoda, Nobuyuki Takei, Hiroyuki Nawa, Akihiko Ogura, Keiko Tominaga-Yoshino

    NEUROSCIENCE LETTERS　Vol. 406　No. 1-2　p. 38-42　2006/10　Research paper (scientific journal)

  23. Long-lasting synaptic loss after repeated induction of LTD: independence to the means of LTD induction

    Yuji Kamikubo, Yoshihiro Egashira, Tsunehiro Tanaka, Yo Shinoda, Keiko Tominaga-Yoshino, Akihiko Ogura

    EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 24　No. 6　p. 1606-1616　2006/09　Research paper (scientific journal)

  24. Long-lasting synapse formation in cultured rat hippocampal neurons after repeated PKA activation

    Akihiko OguraMegumi Yamamoto, Tomoyoshi Urakubo, Keiko Tominaga-Yoshino, Akihiko Ogura

    Brain Research　Vol. 1042　No. 1　p. 6-16　2005/04　Research paper (scientific journal)

  25. The dendritic layer-specific persistent enhancement of synaptic transmission induced by repetitive activation of protein kinase A

    Y Shinoda, K Tominaga-Yoshino, A Ogura

    NEUROSCIENCE RESEARCH　Vol. 47　No. 2　p. 191-200　2003/10　Research paper (scientific journal)

  26. Survival promotion of rat cerebellar granule neurons by co-culture with pontine explant.

    Morita, D, Tominaka-Yoshino, K, Ogura, A

    Brain Research 982(1):1-11　Vol. 982　No. 1　p. 1-11　2003/08　Research paper (scientific journal)

  27. Non-synaptic exocytosis enhanced in rat cerebellar granule neurons cultured under survival-promoting conditions.

    Urakubo, T, Tominaga-Yoshino, K, Ogura, A

    Neuroscience Research 45(4): 429-436　Vol. 45　No. 4　p. 429-436　2003/04　Research paper (scientific journal)

    Publisher: Elsevier Science B.V.

  28. Repetitive Activation of Protein Kinase A induced Slow and Persistent Potentiation Associated with Synaptogenesis in Cultured Hippocampus.

    K.Tominaga-Yoshino, S.Kondo, S.Tamotsu, A.Ogura

    Neuroscience Research, 44, 4, 357-367　Vol. 44　No. 4　p. 357-367　2002/12　Research paper (scientific journal)

  29. Ultrafilter co-culture, a novel method for estimation of molecular mass of bioactive substances, indicates a small molecule neurotrophic substance is released from cultured cerebellar granule neurons of the BALB/c mouse.

    N.Fujikawa, T.Shimonaga, K.Tominaga-Yoshino, A.Ogura

    Brain Research, 947, 2, 243-251　Vol. 947　No. 2　p. 243-51　2002/08　Research paper (scientific journal)

    Publisher: Elsevier Science B.V.

  30. Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA

    K Tominaga-Yoshino, T Uetsuki, K Yoshikawa, A Ogura

    BRAIN RESEARCH　Vol. 918　No. 1-2　p. 121-130　2001/11　Research paper (scientific journal)

  31. The Postmitotic Growth Suppressor Necdin Interacts with a Calcium Binding Protein (NEFA) in Neuronal Cytoplasm.

    N.Taniguchi, H.Taniura, M.Niinobe, C.Takayama, K.Tominaga-Yoshino, A.Ogura, K.Yoshikawa

    J Biol Chem.　Vol. 275　No. 41　p. 31674-81　2000/10　Research paper (scientific journal)

  32. Depolarization-Dependent Survival of Cultured Mouse Cerebellar Granule Neurons is Strain-Restrained.

    N.Fujikawa, K.Tominaga-Yoshino, M.Okabe, A.Ogura

    EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 12　No. 5　p. 1838-1842　2000/05　Research paper (scientific journal)

  33. Increased exocytotic capability of rat cerebellar granule neurons cultured under depolarizing conditions

    S Yamagishi, N Fujikawa, K Kohara, K Tominaga-Yoshino, A Ogura

    NEUROSCIENCE　Vol. 95　No. 2　p. 473-479　2000　Research paper (scientific journal)

  34. Phase dependent response of vasoactive intestinal polypeptide to light and darkness in the suprachiasmatic nucleus

    K Shinohara, K Tominaga, SIT Inouye

    NEUROSCIENCE RESEARCH　Vol. 33　No. 2　p. 105-110　1999/02　Research paper (scientific journal)

  35. Activity-Dependent Survival and Enhanced Turnover of Calcium in Cultured Rat Cerebellar Granule Neurons.

    K.Kohara, T.Ono, K.Tominaga-Yoshino, T.Shimonaga, S.Kawashima, A.Ogura

    BRAIN RESEARCH　Vol. 809　No. 2　p. 231-237　1998/11　Research paper (scientific journal)

  36. Luminance-dependent decrease in vasoactive intestinal polypeptide in the rat suprachiasmatic nucleus

    K Shinohara, K Tominaga, SIT Inouye

    NEUROSCIENCE LETTERS　Vol. 251　No. 1　p. 21-24　1998/07　Research paper (scientific journal)

  37. Glutamate responsiveness enhanced in neurones expressing amyloid precursor protein

    Tominaga K, Uetsuki T, Ogura A, Yoshikawa K

    Neuroreport　Vol. 8　No. 8　p. 2067-2072　1997/05　Research paper (scientific journal)

  38. kappa-Opioid Receptor Agonist Protects against Ischemic Reduction of 2-Deoxyglucose Uptake in Morphine-Tolerant Rats.

    S.Shibata, K.Tominaga, S.Watanabe

    1995/06　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  39. Calcium Channel Blockers Improve Hypoxia/Hypoglycemia-Induced Impairment of Rat Hippocampal 2-Deoxyglucose Uptake In Vitro after Ethanol Withdrawal.

    S.Shibata, T.Shindou, K.Tominaga, S.Watanabe

    1995/03　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  40. Glutathione Protects Against Hypoxic/Hypoglycemic Decreases in 2-Deoxyglucose Uptake and Presynaptic Spikes in Hippocampal Slices.

    S.Shibata, K.Tominaga, S.Watanabe

    1995/01　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  41. Organotypic Slice Culture of the Suprachiasmatic Nucleus.

    K.Tominaga, H.Okamura, SIT.Inouye

    Neurosci Biobehav Rev　Vol. 18　p. 601-604　1994/12　Research paper (scientific journal)

    Publisher: Elsevier Science Ltd.

  42. Effects of Naloxone, Morphine and Kappa-opioid Receptor Agonists on Hypoxia/Hypoglycemia-Induced Reduction of 2-Deoxyglucose Uptake in Hippocampal Slices from U-50,488H-tolerant Rats.

    S.Shibata, K.Tominaga, S.Watanabe

    1994/12　Research paper (scientific journal)

    Publisher: Elsevier Science Ireland Ltd.

  43. Involvement of Vasoactive Intestinal Polypeptide in NMDA-Induced Phase Delay of Firing Activity Rhythm in the Suprachiasmatic Nucleus In Vitro.

    S.Shibata, M.Ono, K.Tominaga, T.Hamada, A.Watanabe, S.Watanabe

    Neurosci Biobehav Rev　Vol. 18　No. 4　p. 591-595　1994/12　Research paper (scientific journal)

    Publisher: Elsevier Science Ltd.

  44. Calcium Imaging in Organotypic Cultures of the Rat Suprachiasmatic Nucleus.

    K.Tominaga, ME.Geusz, S.Michel, SIT.Inouye

    NEUROREPORT　Vol. 5　No. 15　p. 1901-1905　1994/10　Research paper (scientific journal)

  45. Automated Collection of Conditioned Medium from Organotypically Cultured Brain Slice.

    A.Ogura, K.Tominaga, M.Nakazawa, K.Sugaya, SIT.Inouye, Y.Kudo

    NEUROSCIENCE RESEARCH　Vol. 20　No. 4　p. 299-307　1994/10　Research paper (scientific journal)

  46. Day-night Variation of Preprosomatostatin Messenger RNA Level in the Suprachiasmatic Nucleus In Vitro.

    J.Yang, K.Tominaga, Y.Otori, C.Fukuhara, A.Tokumasu, SIT.Inouye

    1994/04　Research paper (scientific journal)

    Publisher: Elsevier Science Ltd.

  47. Organotypic Slice Culture of the Rat Suprachiasmatic Nucleus: Sustenance of Cellular Architecture and Circadian Rhythm.

    K.Tominaga, SIT.Inouye, H.Okamura

    NEUROSCIENCE　Vol. 59　No. 4　p. 1025-1042　1994/04　Research paper (scientific journal)

  48. Morphological Survey of the Suprachiasmatic Nucleus in Slice Culture Using Roller Tube Method: 2.Peptidergic Neurons.

    H.Okamura, K.Tominaga, Y.Ban, C.Fukuhara, N.Yanaihara, Y.Ibata, SIT.Inouye

    Proceedings of the Japanese Histochemical Association　Vol. 27　No. 2　p. 171-179　1994/02　Research paper (scientific journal)

    Publisher: The Japan Society of Histochemistry and Cytochemistry

  49. Morphological Survey of the Suprachiasmatic Nucleus in Slice Culture Using Roller Tube Method: 1.Architecture of the Suprachiasmatic Nucleus In Vitro.

    H.Okamura, K.Tominaga, Y.Ban, M.Tanaka, Y.Tamada, SIT.Inouye, Y.Ibata

    Proceedings of the Japanese Histochemical Association　Vol. 27　No. 2　p. 159-169　1994/02　Research paper (scientific journal)

    Publisher: The Japan Soceity of Histochemistry and Cytochemistry

  50. GABA┣D2A┫D2 Receptor Agonist Muscimol can Reset the Phase of Neural Activity Rhythm in the Rat Suprachiasmatic Nucleus In Vitro.

    K.Tominaga, S.Shibata, T.Hamada, S.Watanabe

    NEUROSCIENCE LETTERS　Vol. 166　No. 1　p. 81-84　1994/01　Research paper (scientific journal)

  51. Effect of Somatostatin on Circadian Rhythms of Firing and 2-Deoxyglucose Uptake in Rat Suprachiasmatic Slices.

    T.Hamada, S.Shibata, A.Tsuneyoshi, K.Tominaga, S.Watanabe

    Am J Physiol　Vol. 265　No. 5 Pt 2　p. R1199-R1204　1993/11　Research paper (scientific journal)

    Publisher: The American Physiological Society

  52. Processing of Photic Information within the Intergeniculate Leaflet of the Lateral Geniculate Body: Assessed by Neuropeptide Y Immunoreactivity in the Suprachiasmatic Nucleus of Rats.

    K.Shinohara, K.Tominaga, C.Fukuhara, Y.Otori, SIT.Inouye

    Neuroscience　Vol. 56　p. 813-822　1993/10　Research paper (scientific journal)

    Publisher: Pergamon-Elsevier Science Ltd.

  53. Substance P-like Immunoreactivity in the Suprachiasmatic Nucleus of the Rat.

    Y.Otori, K.Tominaga, C.Fukuhara, J.Yang, S.Yamazaki, FR.Cagampang, H.Okamura, SIT.Inouye

    1993/08　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  54. Endogenous Circadian Rhythmicity of Somatostatin Like-immunoreactivity in the Rat Suprachiasmatic Nucleus.

    C.Fukuhara, K.Shinohara, K.Tominaga, Y.Otori, SIT.Inouye

    1993/03　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  55. Photic Regulation of Peptides Located in the Ventrolateral Subdivision of the Suprachiasmatic Nucleus of the Rat: Daily Variations of Vasoactive Intestinal Polypeptide, Gastrin-releasing Peptide, and Neuropeptide Y.

    K.Shinohara, K.Tominaga, Y.Isobe, SIT.Inouye

    J. Neurosci.　Vol. 13　p. 793-800　1993/02　Research paper (scientific journal)

    Publisher: Society for Neuroscience

  56. Ischemia-Induced Impairment of 2-Deoxyglucose Uptake and CA1 Field Potentials in Rat Hippocampal Slices: Protection by 5-HT1A Receptor Agonists and 5-HT2 Receptor Antagonists.

    S.Shibata, Y.Kagami-Ishi, K.Tominaga, K.Kodama, S.Ueki, S.Watanabe

    Eur J Pharmacol　Vol. 229　p. 21-29　1992/12　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  57. Effect of Substance P on Circadian Rhythms of Firing Activity and the 2-Deoxyglucose Uptake in the Rat Suprachiasmatic Nucleus In Vitro.

    S.Shibata, A.Tsuneyoshi, T.Hamada, K.Tominaga, S.Watanabe

    BRAIN RESEARCH　Vol. 597　No. 2　p. 257-263　1992/12　Research paper (scientific journal)

  58. Effect of Muscarinic Cholinergic Drugs on Ischemia-Induced Decreases in Glucose Uptake and CA1 Field Potentials in Rat Hippocampus Slices.

    S.Shibata, K.Kodama, K.Tominaga, T.Tanaka, S.Watanabe

    1992/10　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  59. Neuroprotective Effect of Protein Kinase C Inhibitors on Oxygen/Glucose Free-Induced Decreases in 2-Deoxyglucose Uptake and CA1 Field Potentials in Rat Hippocampal Slices.

    S.Shibata, K.Tominaga, Y.Kagami-ishi, S.Watanabe

    1992/10　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  60. Assessment of the Role of Adrenoceptor Function in Ischemia-Induced Impairment of 2-Deoxyglucose Uptake and CA1 Field Potential in Rat Hippocampal Slices.

    S.Shibata, K.Kodama, K.Tominaga, S.Ueki, S.Watanabe

    1992/10　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  61. A Neuroprotective Effect of Adenosine A1-receptor Agonists on Ischemia-induced Decrease in 2-Deoxyglucose Uptake in Rat Hippocampal Slices.

    K.Tominaga, S.Shibata, S.Watanabe

    1992/09　Research paper (scientific journal)

    Publisher: Elsevier Science Ireland LTD.

  62. Circadian Rhythms of Vasopressin Content in the Suprachiasmatic Nucleus of the Rat.

    K.Tominaga, K.Shinohara, Y.Otori, C.Fukuhara, SIT.Inouye

    Neuroreport, 3, 9, 809-812　Vol. 3　No. 9　p. 809-812　1992/09　Research paper (scientific journal)

  63. An in Vitro Circadian Rhythm of Protein Synthesis in the Rat Suprachiasmatic Nucleus under Tissue Culture Conditions.

    S.Shibata, T.Hamada, K.Tominaga, S.Watanabe

    BRAIN RESEARCH　Vol. 584　No. 1-2　p. 251-256　1992/07　Research paper (scientific journal)

  64. Effects of Inhibitory and Excitatory Drugs on the Metabolic Rhythm of the Hamster Suprachiasmatic Nucleus In Vitro.

    K.Tominaga, S.Shibata, S.Ueki, S.Watanabe

    Vol. 217　No. 1　p. 79-84　1992/06　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  65. Phase-resetting Effect of 8-OH-DPAT, a Serotonin1A Receptor Agonist, on the Circadian Rhythm of Firing Rate in the Rat Suprachiasmatic Nuclei in Vitro.

    S.Shibata, A.Tsuneyoshi, T.Hamada, K.Tominaga, S.Watanabe

    Brain Res　Vol. 582　p. 353-356　1992/06　Research paper (scientific journal)

    Publisher: Elsevier Science Publishers B.V.

  66. Excitatory Effect of N-Methyl-D-aspartate and Kainate Receptor on the 2-Deoxyglucose Uptake in the Rat Suprachiasmatic Nucleus In Vitro.

    S.Shibata, K.Tominaga, T.Hamada, S.Watanabe

    NEUROSCIENCE LETTERS　Vol. 139　No. 1　p. 83-86　1992/05　Research paper (scientific journal)

  67. Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters.

    Tominaga K, Shibata S, Ueki S, Watanabe S

    Tominaga K, Shibata S, Ueki S, Watanabe S.　Vol. 214　No. 1　p. 79-84　1992　Research paper (scientific journal)

  68. Behavioral Pharmacological and Electroencephalographic Effects of the 5-HT1A Partial Agonist Ipsapirone.

    T.Yamamoto, S.Shibata, K.Teshima, Y.Inoue, M.Ushio, K.Tominaga, M.Ohno, S.Watanabe, S.Ueki

    Folia Pharmacologica Japonica　Vol. 98　No. 1　p. 41-52　1991/07　Research paper (scientific journal)

    Publisher: 社団法人 日本薬理学会

  69. Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic

    Kataoka Y, Shibata K, Miyazaki A, Inoue Y, Tominaga K, Koizumi S, Ueki S, Niwa M

    Neuropharmacology　Vol. 30　p. 475-480　1991/05　Research paper (scientific journal)

  70. A Key Role of the Mammillary Body in Mediation of the Antianxiety Action of Zopiclone, a Cyclopyrrolone Derivative.

    K.Yamashita, Y.Kataoka, A.Miyazaki, K.Shibata, K.Tominaga, S.Ueki

    Journal of Pharmacological Sciences　Vol. 51　No. 3　p. 438-442　1989/11　Research paper (scientific journal)

    Publisher: 社団法人 日本薬理学会

Misc. 40

  1. 時差ぼけがストレス神経系を動かすとき

    岡村均, 山口賀章, 冨永恵子

    科学　Vol. 94　No. 3　p. 248-253　2024　Article, review, commentary, editorial, etc. (scientific journal)

  2. cutting-edge medicine 体内時計のprecision medicine 時計遺伝子と体内時計システム

    冨永 恵子, 岡村 均

    Precision Medicine　Vol. 6　No. 5　p. 333-336　2023/05　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: (株)北隆館

  3. 【体内時計のprecision medicine】時差ぼけはなぜ起こるのか 生物が初めて直面したリズム異常

    山口 賀章, 冨永 恵子, 岡村 均

    Precision Medicine　Vol. 6　No. 5　p. 358-361　2023/05　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: (株)北隆館

  4. Cell biology of memeory consolidation -- Toward a paradigm shift in memory research

    Akihiko Ogura, Keiko Tominaga-Yoshino

    KAGAKU　Vol. 84　No. 3　p. 256-262　2014/03

    Publisher: 岩波書店

  5. Dendritic spine dynamics in the long-lasting synaptic suppression after repetitive LTD induction

    Sho Hasegawa, Yuki Oe, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 63　p. S186-S186　2013　Research paper, summary (international conference)

  6. Possibility of repetitive LTP-induced long-lasting synaptic enhancement in the mossy fiber-CA3 pathway

    R. Ariga, K. Tanimoto, K. Tominaga-Yoshino, A. Ogura

    JOURNAL OF NEUROCHEMISTRY　Vol. 123　p. 59-59　2012/10　Research paper, summary (international conference)

  7. Expression and distribution of GluR1 subunit of glutamate receptor during development of long-lasting synaptic enhancement coupled with synaptogenesis

    Tomoyoshi Urakubo, Katsuhiro Kawaai, Akihiko Ogura, Keiko Tominaga-Yoshino

    NEUROSCIENCE RESEARCH　Vol. 71　p. E217-E218　2011　Research paper, summary (international conference)

  8. Dendritic spine formation depends on the density of existing spines

    Yuki Oe, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 71　p. E219-E219　2011　Research paper, summary (international conference)

  9. Signalling at the synapse: PKA

    Akihiko Ogura, Keiko Tominaga-Yoshino

    Seitai no Kagaku　2010/09

  10. Persistent synaptic plasticity in the hippocampocortical pathway reproduced in vitro

    Yuki Oe, Kazuyuki Iijima, Takuhiro Kawakami, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 68　p. E345-E346　2010　Research paper, summary (international conference)

  11. Long-lasting memory and information transfer: Time-dependent shift in the distribution of neurons activated upon the retrieval of conditioned fear

    Akihiko Ogura, Tomohiko Matsuzaki, Keiko Tominaga-Yoshino

    NEUROSCIENCE RESEARCH　Vol. 68　p. E346-E346　2010　Research paper, summary (international conference)

  12. Contribution of extrasynaptic CP-AMPAR to long-lasting synaptic enhancement

    Tomoyoshi Urakubo, Keita Asai, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 60　p. S128-S128　2010　Research paper, summary (international conference)

  13. The mechanisms of brain memory and evolution

    A Ogura, Y Egashira, T Urakubo, K Tominaga-Yoshino

    Brain Medical　2009/03

  14. IS MEMORY TRANSFER REPRODUCIBLE IN VITRO? A LONG-LASTING SYNAPTIC ENHANCEMENT AFTER REPEATED LTP INDUCTION IN CULTURED BRAIN SLICE

    Kazuyuki Iijima, Yuki Oe, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 59　p. 137-137　2009　Research paper, summary (international conference)

  15. Possible involvement of proBDNF-p75(NTR) signaling in LTD-repetition-operated synaptic suppression, a form of long-lasting synaptic plasticity

    Yoshihiro Egashira, Masami Kojima, Hara Tomoko, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 65　p. S145-S145　2009　Research paper, summary (international conference)

  16. POSSIBLE INVOLVEMENT OF proBDNF-P75NTR SIGNALS IN LTD-REPETITION OPERATED SYNAPTIC SUPPRESSION, A FORM OF LONG-LASTING SYNAPTIC PLASTICITY

    Yoshihiro Egashira, Masami Kojima, Keiko Tominaga-Yoshino, Akihiko Ogura

    JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 59　p. 186-186　2009　Research paper, summary (international conference)

  17. Repetitive-LTP-induced synaptic enhancement (RISE) established locally by local LTP induction

    Yuki Oe, Yoshihiro Egashira, Yo Shinoda, Akihiko Ogura, Keiko Tominaga-Yoshino

    NEUROSCIENCE RESEARCH　Vol. 61　p. S143-S143　2008　Research paper, summary (international conference)

  18. Genes associated with long-lasting synaptic enhancement in hippocampal slices after repetitive glutamate stimulation

    T. Tashiro, K. Kawaai, K. Tominaga-Yoshino, N. Taniguchi, H. Tashiro, A. Ogura

    JOURNAL OF NEUROCHEMISTRY　Vol. 102　p. 276-276　2007/08　Research paper, summary (international conference)

  19. 記憶・忘却とシナプス結合の変化

    小倉明彦, 浦久保知佳, 江頭良明, 冨永(吉野)恵子

    Brain Medical　2007/06

    Publisher: メディカルレビュー社

  20. Further evidence for the distinction between LTP and RISE, a long-lasting synaptic plasticity accompanied by synaptogenesis

    Keiko Tominaga-Yoshino, Tomoyoshi Urakubo, Masayoshi Okada, Hiroko Matsuda, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 58　p. S53-S53　2007　Research paper, summary (international conference)

  21. Critical time window of protein synthesis required for LOSS, a long-lasting decrease in synaptic strength accompanied by synapse elimination

    Yoshihiro Egashira, Tsunehiro Tanaka, Yuji Kamikubo, Yo Shinoda, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 58　p. S135-S135　2007　Research paper, summary (international conference)

  22. Involvement of Ca2+-permeable AMPAR in the repetitive-LTP induced synaptic enhancement (RISE)

    Yukiko Ueno, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 55　p. S208-S208　2006　Research paper, summary (international conference)

  23. Long-lasting synaptic decrement following repeated inductions of mGluR-dependent LTD requires protein synthesis

    Yoshihiro Egashira, Tsunehiro Tanaka, Yuji Kamikubo, Yo Shinoda, Keiko Tominaga-Yoshino, Akihiko Ogura

    NEUROSCIENCE RESEARCH　Vol. 55　p. S208-S208　2006　Research paper, summary (international conference)

  24. Reproducing brain's long-lasting memory in vitro

    Keiko Tominaga-Yoshino

    Vol. 57　No. 3　p. 51-53　2005/07

    Publisher: 生産と技術振興協会

  25. 忘れさせタンパク質

    小倉明彦, 冨永恵子

    生体の科学, 55:490-491　Vol. 55:490-491　2004/10

    Publisher: 医学書院

  26. Involvement of MAP kinase pathway in the glutamate-induced long-lasting synaptogenesis of the cultured hippocampal slice.

    K Okuhara, K Tominaga-Yoshino, A Ogura

    JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 91　p. 128P-128P　2003　Research paper, summary (international conference)

  27. To make synapses ready for next plasticity.

    Y Shinoda, K Tominaga-Yoshino, A Ogura

    JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 91　p. 179P-179P　2003　Research paper, summary (international conference)

  28. Mechanical stimulus-induced calcium wave in cultured hippocampal astrocytes.

    T Miki, K Tominaga-Yoshino, A Ogura

    JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 91　p. 190P-190P　2003　Research paper, summary (international conference)

  29. 脳機能の解明－21世紀に向けて（赤池紀扶 他編） アデノウイルスベクターを用いた神経細胞への外来遺伝子導入－その一応用例としてのアミロイド前駆体蛋白の機能解析

    九州大学出版会　Vol. 31-38　1998

  30. 組織培養の技術－基礎編 5－2神経細胞培養法

    朝倉書店　Vol. 110-114　1996

  31. ガラスの上で時を刻む脳の生物時計

    井上慎一, 冨永恵子, 小倉明彦, 岡村均

    蛋白・核酸・酵素 532: 表紙&pp.1876　1995/05

  32. Opioid Receptor

    T.Oka, T.Matsumiya, N.Ohgiya, K.Tomianga

    1994/12

  33. ターミナルケアにおける鎮痛薬使用に関連した基礎的研究

    冨永恵子

    Annual Report of Sasakawa Health Science Foundation, 10, 1, 1994　1994/07

    Publisher: 財団法人 笹川医学医療研究財団

  34. Roller Tube Technique for Organotypic Culture of Brain Slices: The Method and Application for Analysis of Neural Function.

    TOMINAGA Keiko, OGURA Akihiko

    1994/01

  35. The Roller-Tube Technique for Brain Slice Cutlrues.

    K.Tominaga, K.Noguchi

    1992/11

    Publisher: 羊土社

  36. ほ乳類生物時計の歯車を探る－視交叉上核におけるペプチドとそのmRNAのリズム－

    冨永恵子, 篠原一之, 竹内潤一, 福原千秋, 大鳥安正, 徳増亜古, 井上慎一

    遺伝　Vol. 46　No. 10　p. p70-75　1992/10

    Publisher: 裳華房

  37. Circadian Rhythms in Suprachiasmatic Cells.

    SIT.Inouye, K.Shinohara, K.Tominaga, T.Fukuhara, A.Tokumasu

    Vol. 42　No. 6　p. p589-595　1991/12

    Publisher: 医学書院

  38. Brain Neuronal Mechanisms of Circadian Rhythms in Mammalians.

    Shigenobu Shibata, Keiko Tominaga

    Journal of the Pharmaceutical Society of Japan　Vol. 111　No. 6　p. p270-283　1991/06

    Publisher: 薬学会

  39. 生物のサーカディアンリズム ３．高等動物

    柴田重信, 冨永恵子

    化学と生物, 29, 2, 124-131　Vol. 29　No. 2　p. p124-131　1991/02

    Publisher: 学会出版センター

  40. Physiological and Pharmacological Studies of the Function of Suprachiasmatic Nucleus in Relation to Its Electrical and Metabolic Activity.

    Shigenobu Shibata, Keiko Tominaga

    1990/12

    Publisher: 医学書院

Publications 14

  1. Chronobiology and Chronomedicine: From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks

    Keiko Tominaga, Hitoshi Okamura

    ROYAL SOCIETY OF CHEMISTRY　2024/01

    ISBN: 9781839162008

  2. Encyclopedia of Sleep and Circadian Rhythms 2nd Edition

    Keiko Tominaga, Hitoshi Okamura

    2023/01/01

    ISBN: 9780128229637

  3. 睡眠学（第２版）

    岡村均, 冨永恵子

    朝倉書店　2020/11

    ISBN: 9784254301205

  4. Cell Biology of Memory

    Akihiko Ogura, Keiko Tominaga

    Asakura Shoten Co. Ltd.　2011/02　Scholarly book

    ISBN: 4254177437

  5. Culture of mammalian organs and tissues, In Methods in Molecular Biology "Circadian rhythm" pp481-492,Rosato, Ezio (ed).

    K. Tominaga-Yoshino, T. Ueyama, H. Okamura

    Humana Press　2007/01　Scholarly book

  6. 神経活動の繰り返し活性化による長期的シナプス新生の観察

    冨永, 恵子

    [冨永恵子(吉野恵子)]　2004/03

  7. ニューロンの生物学

    小倉明彦, 冨永恵子

    南江堂　1999/03　Textbook, survey, introduction

    ISBN: 9784524224319

  8. 脳機能の解明－21世紀に向けて（赤池紀扶 他編）アデノウイルスベクターを用いた神経細胞への外来遺伝子導入－その一応用例としてのアミロイド前駆体蛋白の機能解析

    冨永-吉野恵子, 植月太一, 吉川和明, 小倉明彦

    九州大学出版会　1998/06　Scholarly book

  9. 神経細胞培養法 スライス回転培養系

    冨永恵子

    シュプリンガー・フェアラーク東京　1997/04　Scholarly book

  10. 組織培養の技術－基礎編 5－2神経細胞培養法

    小倉明彦, 冨永恵子

    朝倉書店　1996/04　Scholarly book

  11. Evolution of Circadian Clock. Neuropeptides Involved in the Regulation of Circadian Function in the Suprachiasmatic Nucleus.

    SIT.Inouye, K.Tominaga

    Hokkaido University Press, Sapporo　1994/04　Scholarly book

  12. New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus. Chapter20:Role of 5-HT1A Receptor Mechanism in the Circadian Systems: Assessment by Wheel-Running Behavior, and 2-Deoxyglucose Uptake and Firing Discharge in the Rodent Suprachiasmatic Nuclei.

    S.Shibata, K.Tominaga, T.Hamada, S.Tsuneyoshi, S.Watanabe

    John Libbey, London　1993/12　Scholarly book

  13. New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus. Chapter22:Circadian Rhythms in Peptides and their Precursor Messenger RNAs in the Suprachiasmatic Nucleus.

    SIT.Inouye, K.Shinohara, K.Tominaga, J.Takeuchi, H.Nagasaki, Y.Isobe, C.Fukuhara, Y.Otori, J.Yang, FRA.Cagampang, S.Yamazaki, A.Tokumasu

    John Libbey, London　1993/12　Scholarly book

  14. Frontiers of Photobiology. A Circadian Pacemaker in the Suprachiasmatic Nucleus and Its Interaction with Light.

    SIT.Inouye, K.Shinohara, K.Tominaga, Y.Otori, C.Fukuhara, J.Yang

    Elsevier Science Publishers, Amsterdam　1993/03　Scholarly book

Media Coverage 1

  1. 記憶固定にストレスが悪影響

    ヤフーニュース、時事通信ほか

    2016/02