Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation

Yumiko Tanaka, Mai Yamagishi, Yasutaka Motomura, Takashi Kamatani, Yusuke Oguchi, Nobutake Suzuki, Tsuyoshi Kiniwa, Hiroki Kabata, Misato Irie, Tatsuhiko Tsunoda, Fuyuki Miya, Keisuke Goda, Osamu Ohara, Takashi Funatsu, Koichi Fukunaga, Kazuyo Moro, Sotaro Uemura, Yoshitaka Shirasaki

Communications Biology　Vol. 6　No. 1　2023/09/06　Research paper (scientific journal)

Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s.

Misato Irie, Hiroki Kabata, Kotaro Sasahara, Momoko Kurihara, Yoshitaka Shirasaki, Takashi Kamatani, Rie Baba, Masako Matsusaka, Satoshi Koga, Katsunori Masaki, Jun Miyata, Yasutomo Araki, Toru Kikawada, Yasuaki Kabe, Makoto Suematsu, Mai Yamagishi, Sotaro Uemura, Kazuyo Moro, Koichi Fukunaga

Cell reports　Vol. 42　No. 6　p. 112610-112610　2023/06/07　Research paper (scientific journal)

Crossing the valley of death: Toward translational research regarding ILC2.

Takuya Yashiro, Kazuyo Moro

Allergology international : official journal of the Japanese Society of Allergology　Vol. 72　No. 2　p. 187-193　2023/04　Research paper (scientific journal)

The latest findings on ILC2s, from bench to bedside.

Kazuyo Moro

Allergology international : official journal of the Japanese Society of Allergology　Vol. 72　No. 2　p. 185-186　2023/04

加齢による肺の自然リンパ球サブセットの変化と免疫応答への影響

浅岡 雅人, 小林 哲郎, 加畑 宏樹, 福永 興壱, 茂呂 和世

日本呼吸器学会誌　Vol. 12　No. 増刊　p. 149-149　2023/03

Identification of a novel enhancer essential for Satb1expression in TH2 cells and activated ILC2s

Aneela Nomura, Michiko Ohno-Oishi, Tetsuro Kobayashi, Wooseok Seo, Kiyokazu Kakugawa, Sawako Muroi, Hideyuki Yoshida, Takaho A. Endo, Kazuyo Moro, Ichiro Taniuchi

Life science alliance　Vol. 6　No. 8　2023/01/03　Research paper (scientific journal)

Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients

Rie Baba, Hiroki Kabata, Yoshitaka Shirasaki, Takashi Kamatani, Mai Yamagishi, Misato Irie, Risa Watanabe, Masako Matsusaka, Katsunori Masaki, Jun Miyata, Kazuyo Moro, Sotaro Uemura, Koichi Fukunaga

Journal of Allergy and Clinical Immunology: Global　Vol. 1　No. 4　p. 299-304　2022/11　Research paper (scientific journal)

A spontaneous pulmonary fibrosis mouse model identifies a mechanism for ILC2-mediated irreversible fibrosis

Kazuyo Moro, Natsuko Otaki, Yasutaka Motomura, Tommy Terooatea, S. Thomas Kelly, Miho Mochizuki, Natsuki Takeno, Shigeo Koyasu, Fuminori Sugihara, Junichi Kikuta, Hideya Kitamura, Yoshiki Shiraishi, Jun Miyanohara, Yuji Nagano, Yuji Saita, Takashi Ogura, Koichiro Asano, Aki Minoda

2022/05/03　Research paper (scientific journal)

ILCs and Allergy.

Hiroki Kabata, Yasutaka Motomura, Tsuyoshi Kiniwa, Tetsuro Kobayashi, Kazuyo Moro

Advances in experimental medicine and biology　Vol. 1365　p. 75-95　2022　Research paper (scientific journal)

Tissue-Specific Diversity of Group 2 Innate Lymphoid Cells in the Skin.

Tetsuro Kobayashi, Kazuyo Moro

Frontiers in immunology　Vol. 13　p. 885642-885642　2022　Research paper (scientific journal)

Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin

Yuki Hikichi, Yasutaka Motomura, Osamu Takeuchi, Kazuyo Moro

Journal of Experimental Medicine　Vol. 218　No. 12　2021/12/06　Research paper (scientific journal)

Discovery of group 2 innate lymphoid cells has changed the concept of type 2 immune diseases.

Tetsuro Kobayashi, Yasutaka Motomura, Kazuyo Moro

International immunology　Vol. 33　No. 12　p. 705-709　2021/09/09　Research paper (scientific journal)

Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF and IL-13.

Yoshiki Momiuchi, Yasutaka Motomura, Emiko Suga, Hiroki Mizuno, Junichi Kikuta, Akito Morimoto, Miho Mochizuki, Natsuko Otaki, Masaru Ishii, Kazuyo Moro

International immunology　Vol. 33　No. 11　p. 573-585　2021/09/09　Research paper (scientific journal)

Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation.

Takahiro Matsuyama, Kentaro Machida, Yasutaka Motomura, Koichi Takagi, Yoichi Doutake, Asako Tanoue-Hamu, Kiyotaka Kondo, Keiko Mizuno, Kazuyo Moro, Hiromasa Inoue

Allergy　Vol. 76　No. 9　p. 2785-2796　2021/09　Research paper (scientific journal)

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.

Mathys Grapotte, Manu Saraswat, Chloé Bessière, Christophe Menichelli, Jordan A. Ramilowski, Jessica Severin, Yoshihide Hayashizaki, Masayoshi Itoh, Michihira Tagami, Mitsuyoshi Murata, Miki Kojima-Ishiyama, Shohei Noma, Shuhei Noguchi, Takeya Kasukawa, Akira Hasegawa, Harukazu Suzuki, Hiromi Nishiyori-Sueki, Martin C. Frith, FANTOM consortium, Clément Chatelain, Piero Carninci, Michiel J. L. de Hoon, Wyeth W. Wasserman, Laurent Bréhélin, Charles-Henri Lecellier

Nature communications　Vol. 12　No. 1　2021/06/02　Research paper (scientific journal)

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions.

Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro, Masaru Ishii

The Journal of experimental medicine　Vol. 218　No. 5　2021/05/03　Research paper (scientific journal)

Localization and site-specific cell-cell interactions of group 2 innate lymphoid cells.

Tsuyoshi Kiniwa, Kazuyo Moro

International immunology　Vol. 33　No. 5　p. 251-259　2021/04/22　Research paper (scientific journal)

Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1.

Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Ayuko Sato, Masanori Yoshinaga, Kiminobu Tanizawa, Kizuku Watanabe, Toyohiro Hirai, Kazuo Chin, Yutaka Suzuki, Takuya Uehata, Takashi Mino, Tohru Tsujimura, Kazuyo Moro, Osamu Takeuchi

The European respiratory journal　Vol. 57　No. 3　2021/03　Research paper (scientific journal)

12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice.

Jun Miyata, Yoshiyuki Yokokura, Kazuyo Moro, Hiroyuki Arai, Koichi Fukunaga, Makoto Arita

Frontiers in immunology　Vol. 12　p. 687192-687192　2021　Research paper (scientific journal)

Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice.

Risa Nakamura, Akihiro Yoshizawa, Taeko Moriyasu, Sharmina Deloer, Masachika Senba, Mihoko Kikuchi, Shigeo Koyasu, Kazuyo Moro, Shinjiro Hamano

iScience　Vol. 23　No. 9　p. 101544-101544　2020/09/25　Research paper (scientific journal)

アレルギー性呼吸器疾患のトランスレーショナルリサーチ Single cell解析によるILC2活性化制御遺伝子の検討

桑江 美聡, 加畑 宏樹, 松坂 雅子, 馬塲 里英, 鎌谷 高志, 渡辺 理沙, 正木 克宜, 田野崎 貴絵, 奥隅 真一, 白崎 善隆, 上村 想太郎, 茂呂 和世, 福永 興壱

日本呼吸器学会誌　Vol. 9　No. 増刊　p. 132-132　2020/08

アレルギー性呼吸器疾患のトランスレーショナルリサーチ Single cell解析によるILC2活性化制御遺伝子の検討

桑江 美聡, 加畑 宏樹, 松坂 雅子, 馬塲 里英, 鎌谷 高志, 渡辺 理沙, 正木 克宜, 田野崎 貴絵, 奥隅 真一, 白崎 善隆, 上村 想太郎, 茂呂 和世, 福永 興壱

日本呼吸器学会誌　Vol. 9　No. 増刊　p. 132-132　2020/08

Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis.

Yurina Miyajima, Kafi N Ealey, Yasutaka Motomura, Miho Mochizuki, Natsuki Takeno, Motoko Yanagita, Aris N Economides, Manabu Nakayama, Haruhiko Koseki, Kazuyo Moro

International immunology　Vol. 32　No. 6　p. 407-419　2020/05/30　Research paper (scientific journal)

Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.

Naoko Satoh-Takayama, Tamotsu Kato, Yasutaka Motomura, Tomoko Kageyama, Naoko Taguchi-Atarashi, Ryo Kinoshita-Daitoku, Eisuke Kuroda, James P Di Santo, Hitomi Mimuro, Kazuyo Moro, Hiroshi Ohno

Immunity　Vol. 52　No. 4　p. 635-649　2020/04/14　Research paper (scientific journal)

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s.

Marek Wagner, Kafi N Ealey, Hiroe Tetsu, Tsuyoshi Kiniwa, Yasutaka Motomura, Kazuyo Moro, Shigeo Koyasu

Cell reports　Vol. 30　No. 8　p. 2743-2757　2020/02/25　Research paper (scientific journal)

A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.

Xi Jiang, Ashutosh Kumar, Yasutaka Motomura, Tian Liu, Yong Zhou, Kazuyo Moro, Kam Y J Zhang, Qing Yang

Journal of medicinal chemistry　Vol. 63　No. 3　p. 987-1001　2020/02/13　Research paper (scientific journal)

肥満の誘導における自然リンパ球の役割

佐々木 崇晴, 茂呂 和世, 小安 重夫

臨床免疫・アレルギー科　Vol. 73　No. 2　p. 220-227　2020/02

Skin-Resident Innate Lymphoid Cells - Cutaneous Innate Guardians and Regulators.

Tetsuro Kobayashi, Roberto R Ricardo-Gonzalez, Kazuyo Moro

Trends in immunology　Vol. 41　No. 2　p. 100-112　2020/02　Research paper (scientific journal)

Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells.

Hiroyuki Hosokawa, Maile Romero-Wolf, Qi Yang, Yasutaka Motomura, Ditsa Levanon, Yoram Groner, Kazuyo Moro, Tomoaki Tanaka, Ellen V Rothenberg

The Journal of experimental medicine　Vol. 217　No. 1　2020/01/06　Research paper (scientific journal)

The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells.

Yasutaka Motomura, Tetsuro Kobayashi, Kazuyo Moro

Immunity　Vol. 51　No. 4　p. 598-600　2019/10/15　Research paper (scientific journal)

Innate Lymphoid Cells in the Induction of Obesity.

Takaharu Sasaki, Kazuyo Moro, Tetsuya Kubota, Naoto Kubota, Tamotsu Kato, Hiroshi Ohno, Susumu Nakae, Hirohisa Saito, Shigeo Koyasu

Cell reports　Vol. 28　No. 1　p. 202-217　2019/07/02　Research paper (scientific journal)

気管支喘息(成人)病態 1細胞分泌活性解析システムを用いた活性化ヒトILC2における遺伝子発現の検討

桑江 美聡, 松坂 雅子, 渡辺 理沙, 古賀 諭, 宮田 楓, 鎌谷 高志, 山岸 舞, 馬塲 里英, 黄川田 徹, 白崎 善隆, 茂呂 和世, 上村 想太郎, 福永 興壱

アレルギー　Vol. 68　No. 4-5　p. 539-539　2019/05

気管支喘息 病態生理 1細胞分泌活性解析システムを用いた活性化ヒトILC2における遺伝子発現の検討

桑江 美聡, 松坂 雅子, 渡辺 理沙, 古賀 諭, 宮田 楓, 鎌谷 高志, 山岸 舞, 馬塲 里英, 黄川田 徹, 白崎 善隆, 茂呂 和世, 上村 想太郎, 福永 興壱

日本呼吸器学会誌　Vol. 8　No. 増刊　p. 152-152　2019/03

ヒト末梢血(2型自然リンパ球)ILC2に対するIL-10の効果の検討

渡辺 理沙, 桑江 美聡, 松坂 雅子, 鎌谷 高志, 山岸 舞, 馬塲 里英, 白崎 善隆, 茂呂 和世, 上村 想太郎, 福永 興壱

日本呼吸器学会誌　Vol. 8　No. 増刊　p. 249-249　2019/03

Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara

Nature communications　Vol. 10　No. 1　p. 1075-1075　2019/03/01　Research paper (scientific journal)

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium.

Tetsuro Kobayashi, Benjamin Voisin, Do Young Kim, Elizabeth A Kennedy, Jay-Hyun Jo, Han-Yu Shih, Amanda Truong, Thomas Doebel, Keiko Sakamoto, Chang-Yi Cui, David Schlessinger, Kazuyo Moro, Susumu Nakae, Keisuke Horiuchi, Jinfang Zhu, Warren J Leonard, Heidi H Kong, Keisuke Nagao

Cell　Vol. 176　No. 5　p. 982-997　2019/02/21　Research paper (scientific journal)

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara

Nature communications　Vol. 10　No. 1　p. 447-447　2019/01/25　Research paper (scientific journal)

Measurement of the Cell Migration and Cytokine Secretion Activity with Real-Time Imaging System

Yumiko Tanaka, Nobutake Suzuki, Kazuyo Moro, Jun Mizuno, Shuichi Shoji, Sotaro Uemura, Yoshitaka Shirasaki

MHS 2018 - 2018 29th International Symposium on Micro-NanoMechatronics and Human Science　2018/12/01　Research paper (international conference proceedings)

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms.

Hiroki Kabata, Kazuyo Moro, Shigeo Koyasu

Immunological reviews　Vol. 286　No. 1　p. 37-52　2018/11　Research paper (scientific journal)

Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.

Satoshi Koga, Katsuto Hozumi, Ken-Ichi Hirano, Masaki Yazawa, Tommy Terooatea, Aki Minoda, Takashi Nagasawa, Shigeo Koyasu, Kazuyo Moro

The Journal of experimental medicine　Vol. 215　No. 6　p. 1609-1626　2018/06/04　Research paper (scientific journal)

好酸球性副鼻腔炎患者の2型自然リンパ球に関する単細胞分泌実時間イメージング法を用いた検討

松坂 雅子, 福永 興壱, 古賀 諭, 宮田 楓, 鎌谷 高志, 馬塲 里英, 山岸 舞, 持丸 貴生, 荒木 康智, 川野 健二, 黄川田 徹, 白崎 善隆, 茂呂 和世, 上村 想太郎, 別役 智子

アレルギー　Vol. 67　No. 4-5　p. 593-593　2018/05

GITR cosignal in ILC2s controls allergic lung inflammation.

Hiroyuki Nagashima, Yuko Okuyama, Tsuyoshi Fujita, Takeo Takeda, Yasutaka Motomura, Kazuyo Moro, Takanori Hidaka, Koki Omori, Tsuyoshi Sakurai, Tomoaki Machiyama, Lishomwa C Ndhlovu, Carlo Riccardi, Takanori So, Naoto Ishii

The Journal of allergy and clinical immunology　Vol. 141　No. 5　p. 1939-1943　2018/05

Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments.

Takashi Kamatani, Koichi Fukunaga, Kaede Miyata, Yoshitaka Shirasaki, Junji Tanaka, Rie Baba, Masako Matsusaka, Naoyuki Kamatani, Kazuyo Moro, Tomoko Betsuyaku, Sotaro Uemura

Scientific reports　Vol. 7　No. 1　p. 16831-16831　2017/12/04　Research paper (scientific journal)

Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice

Risa Nakamura, Sharmina Deloer, Kazuyo Moro, Shinjiro Hamano

CYTOKINE　Vol. 100　p. 130-130　2017/12　Research paper (international conference proceedings)

ディープ・ラーニングを用いたSingle cell解析のためのマイクロウェル内細胞数測定システムの構築

鎌谷 高志, 福永 興壱, 宮田 楓, 白崎 善隆, 田中 順次, 馬塲 里英, 松坂 雅子, 鎌谷 直之, 茂呂 和世, 別役 智子, 上村 想太郎

生命科学系学会合同年次大会　Vol. 2017年度　p. [1P-1406]　2017/12

Live Cell Imaging of Secretion (LCI-S) to track the dynamics of cytokine production from individual immune cells

Yoshitaka Shirasaki, Kaede Miyata, Yumiko Tanaka, Mai Yamagishi, Nobutake Suzuki, Pie Baba, Hiroki Kabata, Koichi Fukunaga, Tomoko Betsuyaku, Osamu Ohara, Kazuyo Moro, Sotaro Uemura

CYTOKINE　Vol. 100　p. 60-61　2017/12　Research paper (international conference proceedings)

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.

Satoshi Kojo, Hirokazu Tanaka, Takaho A Endo, Sawako Muroi, Ye Liu, Wooseok Seo, Mari Tenno, Kiyokazu Kakugawa, Yoshinori Naoe, Krutula Nair, Kazuyo Moro, Yoshinori Katsuragi, Akinori Kanai, Toshiya Inaba, Takeshi Egawa, Byrappa Venkatesh, Aki Minoda, Ryo Kominami, Ichiro Taniuchi

Nature communications　Vol. 8　No. 1　p. 702-702　2017/09/26　Research paper (scientific journal)

FANTOM5 CAGE profiles of human and mouse samples.

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima, Atsutaka Kubosaki, Ri-Ichiroh Manabe, Mitsuyoshi Murata, Sayaka Nagao-Sato, Kenichi Nakazato, Noriko Ninomiya, Hiromi Nishiyori-Sueki, Shohei Noma, Eri Saijyo, Akiko Saka, Mizuho Sakai, Christophe Simon, Naoko Suzuki, Michihira Tagami, Shoko Watanabe, Shigehiro Yoshida, Peter Arner, Richard A Axton, Magda Babina, J Kenneth Baillie, Timothy C Barnett, Anthony G Beckhouse, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, Ailsa J Carlisle, Hans C Clevers, Carrie A Davis, Michael Detmar, Taeko Dohi, Albert S B Edge, Matthias Edinger, Anna Ehrlund, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Mary C Farach-Carson, Geoffrey J Faulkner, Carmelo Ferrai, Malcolm E Fisher, Lesley M Forrester, Rie Fujita, Jun-Ichi Furusawa, Teunis B Geijtenbeek, Thomas Gingeras, Daniel Goldowitz, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Yuki Hasegawa, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, David A Hume, Tomokatsu Ikawa, Yuri Ishizu, Chieko Kai, Hiroshi Kawamoto, Yuki I Kawamura, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, Sarah Klein, S Peter Klinken, Alan J Knox, Soichi Kojima, Haruhiko Koseki, Shigeo Koyasu, Weonju Lee, Andreas Lennartsson, Alan Mackay-Sim, Niklas Mejhert, Yosuke Mizuno, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Kelly J Morris, Hozumi Motohashi, Christine L Mummery, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Tadasuke Nozaki, Soichi Ogishima, Naganari Ohkura, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Swati Pradhan-Bhatt, Xian-Yang Qin, Michael Rehli, Patrizia Rizzu, Sugata Roy, Antti Sajantila, Shimon Sakaguchi, Hiroki Sato, Hironori Satoh, Suzana Savvi, Alka Saxena, Christian Schmidl, Claudio Schneider, Gundula G Schulze-Tanzil, Anita Schwegmann, Guojun Sheng, Jay W Shin, Daisuke Sugiyama, Takaaki Sugiyama, Kim M Summers, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Andru Tomoiu, Hiroo Toyoda, Marc van de Wetering, Linda M van den Berg, Roberto Verardo, Dipti Vijayan, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Yoko Yamaguchi, Masayuki Yamamoto, Chiyo Yanagi-Mizuochi, Misako Yoneda, Yohei Yonekura, Peter G Zhang, Silvia Zucchelli, Imad Abugessaisa, Erik Arner, Jayson Harshbarger, Atsushi Kondo, Timo Lassmann, Marina Lizio, Serkan Sahin, Thierry Sengstag, Jessica Severin, Hisashi Shimoji, Masanori Suzuki, Harukazu Suzuki, Jun Kawai, Naoto Kondo, Masayoshi Itoh, Carsten O Daub, Takeya Kasukawa, Hideya Kawaji, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki

Scientific data　Vol. 4　p. 170112-170112　2017/08/29　Research paper (scientific journal)

Widefield real-time single-cell secretion imaging with optical waveguide technique

Yumiko Tanaka, Nobutake Suzuki, Kazuyo Mora, Jun Mizuno, Shuichi Shoji, Sotaro Uemura, Yoshitaka Shirasaki

TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems　p. 1580-1583　2017/07/26　Research paper (international conference proceedings)

Are ILC2s Jekyll and Hyde in airway inflammation?

Kafi N Ealey, Kazuyo Moro, Shigeo Koyasu

Immunological reviews　Vol. 278　No. 1　p. 207-218　2017/07　Research paper (scientific journal)

Plastic Heterogeneity of Innate Lymphoid Cells in Cancer.

Marek Wagner, Kazuyo Moro, Shigeo Koyasu

Trends in cancer　Vol. 3　No. 5　p. 326-335　2017/05　Research paper (scientific journal)

Stochastic secretion response to transient stimulus of group-2 innate lymphoid cells (ILC2).

Kazuki Yoda, Kaede Miyata, Nobutake Suzuki, Sotaro Uemura, Kazuyo Moro, Yoshitaka Shirasaki

International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017, Nagoya, Japan, December 3-6, 2017　p. 1-5　2017　Research paper (international conference proceedings)

Innate lymphoid cells in allergic and nonallergic inflammation.

Hideaki Morita, Kazuyo Moro, Shigeo Koyasu

The Journal of allergy and clinical immunology　Vol. 138　No. 5　p. 1253-1264　2016/11　Research paper (scientific journal)

Mechanisms to Suppress ILC2-induced Airway Inflammation.

Hiroki Kabata, Kazuyo Moro, Shigeo Koyasu, Koichi Fukunaga, Koichiro Asano, Tomoko Betsuyaku

Annals of the American Thoracic Society　Vol. 13 Suppl 1　2016/03　Research paper (scientific journal)

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

Kazuyo Moro, Hiroki Kabata, Masanobu Tanabe, Satoshi Koga, Natsuki Takeno, Miho Mochizuki, Koichi Fukunaga, Koichiro Asano, Tomoko Betsuyaku, Shigeo Koyasu

NATURE IMMUNOLOGY　Vol. 17　No. 1　p. 76-+　2016/01　Research paper (scientific journal)

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

Laurence D. Hurst, Avazeh T. Ghanbarian, Alistair R.R. Forrest, Lukasz Huminiecki, Michael Rehli, J. Kenneth Baillie, Michiel J.L. de Hoon, Vanja Haberle, Timo Lassmann, Ivan V. Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J. Mungall, Terrence F. Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer, Yulia A. Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A. Semple, Yuri Ishizu, Robert S. Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M. Altschuler, Takahiro Arakawa, John A.C. Archer, Peter Arner, Magda Babina, Sarah Baker, Piotr J. Balwierz, Anthony G. Beckhouse, Swati Bhatt Pradhan, Judith A. Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A. Maxwell Burroughs, Andrea Califano, Carlo V. Cannistraci, Daniel Carbajo, Yun Chen, Marco Chierici, Yari Ciani, Hans C. Clevers, Emiliano Dalla, Carrie A. Davis, Michael Detmar, Alexander D. Diehl, Taeko Dohi, Finn Drabløs, Albert S.B. Edge, Matthias Edinger, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Michela Fagiolini, Lynsey Fairbairn, Hai Fang, Mary C. Farach-Carson, Geoffrey J. Faulkner, Alexander V. Favorov, Malcolm E. Fisher, Martin C. Frith, Rie Fujita, Shiro Fukuda, Cesare Furlanello, Masaaki Furuno, Jun ichi Furusawa, Teunis B. Geijtenbeek, Andrew Gibson, Thomas Gingeras, Daniel Goldowitz, Julian Gough, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J. Ha, Masahide Hamaguchi, Mitsuko Hara, Matthias Harbers, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Takehiro Hashimoto, Meenhard Herlyn, Kelly J. Hitchens, Shannan J. Ho Sui, Oliver M. Hofmann

PLoS biology　Vol. 13　No. 12　2015/12/18　Research paper (scientific journal)

Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage.

Kazuyo Moro

PloS one　2015/12/14　Research paper (scientific journal)

Group 2 innate lymphoid cells and asthma

Hiroki Kabata, Kazuyo Moro, Shigeo Koyasu, Koichiro Asano

ALLERGOLOGY INTERNATIONAL　Vol. 64　No. 3　p. 227-234　2015/07

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

Hideaki Morita, Ken Arae, Hirotoshi Unno, Kousuke Miyauchi, Sumika Toyama, Aya Nambu, Keisuke Oboki, Tatsukuni Ohno, Kenichiro Motomura, Akira Matsuda, Sachiko Yamaguchi, Seiko Narushima, Naoki Kajiwara, Motoyasu Iikura, Hajime Suto, Andrew N. J. McKenzie, Takao Takahashi, Hajime Karasuyama, Ko Okumura, Miyuki Azuma, Kazuyo Moro, Cezmi A. Akdis, Stephen J. Galli, Shigeo Koyasu, Masato Kubo, Katsuko Sudo, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae

IMMUNITY　Vol. 43　No. 1　p. 175-186　2015/07　Research paper (scientific journal)

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells (vol 16, pg 276, 2015)

Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A. Mielke, Shoukat Afshar-Sterle, Seth L. Masters, Susumu Nakae, Hirohisa Saito, John M. Wentworth, Peng Li, Wei Liao, Warren J. Leonard, Gordon K. Smyth, Wei Shi, Stephen L. Nutt, Shigeo Koyasu, Axel Kallies

NATURE IMMUNOLOGY　Vol. 16　No. 5　p. 544-544　2015/05

Isolation and analysis of group 2 innate lymphoid cells in mice

Kazuyo Moro, Kafi N. Ealey, Hiroki Kabata, Shigeo Koyasu

NATURE PROTOCOLS　Vol. 10　No. 5　p. 792-806　2015/05　Research paper (scientific journal)

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Kazuyo Moro

PloS one　2015/03/25　Research paper (scientific journal)

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A. Mielke, Shoukat Afshar-Sterle, Seth L. Masters, Susumu Nakae, Hirohisa Saito, John M. Wentworth, Peng Li, Wei Liao, Warren J. Leonard, Gordon K. Smyth, Wei Shi, Stephen L. Nutt, Shigeo Koyasu, Axel Kallies

NATURE IMMUNOLOGY　Vol. 16　No. 3　p. 276-U239　2015/03　Research paper (scientific journal)

The statistical geometry of transcriptome divergence in cell-type evolution and cancer.

Kazuyo Moro

Nature communications　2015/01/14　Research paper (scientific journal)

Innate lymphoid cells, possible interaction with microbiota

Kazuyo Moro, Shigeo Koyasu

SEMINARS IN IMMUNOPATHOLOGY　Vol. 37　No. 1　p. 27-37　2015/01

Group 2 innate lymphoid cells (ILC2s)

Hiroki Kabata, Kazuyo Moro, Shigeo Koyasu, Koichiro Asano

Japanese Journal of Allergology　Vol. 64　No. 1　p. 46-56　2015　Research paper (scientific journal)

Erratum: Critical role of p38 and GATA3 in natural helper cell function (vol 191, pg 1818, 2013)

Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Kazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Kubo, Shigeo Koyasu

Journal of Immunology　Vol. 193　No. 3　p. 1512-1512　2014/08/01　Research paper (scientific journal)

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes.

Kazuyo Moro

Scientific reports　2014/06/24　Research paper (scientific journal)

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

Yasutaka Motomura, Hideaki Morita, Kazuyo Moro, Susumu Nakae, David Artis, Takaho A. Endo, Yoko Kuroki, Osamu Ohara, Shigeo Koyasu, Masato Kubo

IMMUNITY　Vol. 40　No. 5　p. 758-771　2014/05　Research paper (scientific journal)

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

Kazuyo Moro

Proceedings of the National Academy of Sciences of the United States of America　2014/03/27　Research paper (scientific journal)

Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells.

Kazuyo Moro

PloS one　2014/03/27　Research paper (scientific journal)

A promoter-level mammalian expression atlas.

Alistair R R Forrest, Hideya Kawaji, Michael Rehli, J Kenneth Baillie, Michiel J L de Hoon, Vanja Haberle, Timo Lassmann, Ivan V Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J Mungall, Terrence F Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer, Yulia A Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A Semple, Yuri Ishizu, Robert S Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M Altschuler, Takahiro Arakawa, John A C Archer, Peter Arner, Magda Babina, Sarah Rennie, Piotr J Balwierz, Anthony G Beckhouse, Swati Pradhan-Bhatt, Judith A Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A Maxwell Burroughs, Andrea Califano, Carlo V Cannistraci, Daniel Carbajo, Yun Chen, Marco Chierici, Yari Ciani, Hans C Clevers, Emiliano Dalla, Carrie A Davis, Michael Detmar, Alexander D Diehl, Taeko Dohi, Finn Drabløs, Albert S B Edge, Matthias Edinger, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Michela Fagiolini, Lynsey Fairbairn, Hai Fang, Mary C Farach-Carson, Geoffrey J Faulkner, Alexander V Favorov, Malcolm E Fisher, Martin C Frith, Rie Fujita, Shiro Fukuda, Cesare Furlanello, Masaaki Furino, Jun-ichi Furusawa, Teunis B Geijtenbeek, Andrew P Gibson, Thomas Gingeras, Daniel Goldowitz, Julian Gough, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Matthias Harbers, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Takehiro Hashimoto, Meenhard Herlyn, Kelly J Hitchens, Shannan J Ho Sui, Oliver M Hofmann, Ilka Hoof, Furni Hori, Lukasz Huminiecki, Kei Iida, Tomokatsu Ikawa, Boris R Jankovic, Hui Jia, Anagha Joshi, Giuseppe Jurman, Bogumil Kaczkowski, Chieko Kai, Kaoru Kaida, Ai Kaiho, Kazuhiro Kajiyama, Mutsumi Kanamori-Katayama, Artem S Kasianov, Takeya Kasukawa, Shintaro Katayama, Sachi Kato, Shuji Kawaguchi, Hiroshi Kawamoto, Yuki I Kawamura, Tsugumi Kawashima, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, S Peter Klinken, Alan J Knox, Miki Kojima, Soichi Kojima, Naoto Kondo, Haruhiko Koseki, Shigeo Koyasu, Sarah Krampitz, Atsutaka Kubosaki, Andrew T Kwon, Jeroen F J Laros, Weonju Lee, Andreas Lennartsson, Kang Li, Berit Lilje, Leonard Lipovich, Alan Mackay-Sim, Ri-ichiroh Manabe, Jessica C Mar, Benoit Marchand, Anthony Mathelier, Niklas Mejhert, Alison Meynert, Yosuke Mizuno, David A de Lima Morais, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Efthymios Motakis, Hozumi Motohashi, Christine L Mummery, Mitsuyoshi Murata, Sayaka Nagao-Sato, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Kenichi Nakazato, Erik van Nimwegen, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Shohei Noma, Tadasuke Noazaki, Soichi Ogishima, Naganari Ohkura, Hiroko Ohimiya, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Arnab Pain, Robert Passier, Margaret Patrikakis, Helena Persson, Silvano Piazza, James G D Prendergast, Owen J L Rackham, Jordan A Ramilowski, Mamoon Rashid, Timothy Ravasi, Patrizia Rizzu, Marco Roncador, Sugata Roy, Morten B Rye, Eri Saijyo, Antti Sajantila, Akiko Saka, Shimon Sakaguchi, Mizuho Sakai, Hiroki Sato, Suzana Savvi, Alka Saxena, Claudio Schneider, Erik A Schultes, Gundula G Schulze-Tanzil, Anita Schwegmann, Thierry Sengstag, Guojun Sheng, Hisashi Shimoji, Yishai Shimoni, Jay W Shin, Christophe Simon, Daisuke Sugiyama, Takaai Sugiyama, Masanori Suzuki, Naoko Suzuki, Rolf K Swoboda, Peter A C 't Hoen, Michihira Tagami, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Zuotian Tatum, Mark Thompson, Hiroo Toyodo, Tetsuro Toyoda, Elvind Valen, Marc van de Wetering, Linda M van den Berg, Roberto Verado, Dipti Vijayan, Ilya E Vorontsov, Wyeth W Wasserman, Shoko Watanabe, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Emily J Wood, Yoko Yamaguchi, Masayuki Yamamoto, Misako Yoneda, Yohei Yonekura, Shigehiro Yoshida, Susan E Zabierowski, Peter G Zhang, Xiaobei Zhao, Silvia Zucchelli, Kim M Summers, Harukazu Suzuki, Carsten O Daub, Jun Kawai, Peter Heutink, Winston Hide, Tom C Freeman, Boris Lenhard, Vladimir B Bajic, Martin S Taylor, Vsevolod J Makeev, Albin Sandelin, David A Hume, Piero Carninci, Yoshihide Hayashizaki

Nature　Vol. 507　No. 7493　p. 462-70　2014/03/27　Research paper (scientific journal)

An atlas of active enhancers across human cell types and tissues.

Kazuyo Moro

Nature　2014/03/01　Research paper (scientific journal)

ステロイド抵抗性の喘息病態におけるナチュラルヘルパー細胞の関与

加畑 宏樹, 浅野 浩一郎, 茂呂 和世, 小安 重夫

臨床免疫・アレルギー科　Vol. 61　No. 3　p. 311-316　2014/03

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

Hiroki Kabata, Kazuyo Moro, Koichi Fukunaga, Yusuke Suzuki, Jun Miyata, Katsunori Masaki, Tomoko Betsuyaku, Shigeo Koyasu, Koichiro Asano

NATURE COMMUNICATIONS　Vol. 4　2013/10　Research paper (scientific journal)

Critical Role of p38 and GATA3 in Natural Helper Cell Function

Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Kazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Kubo, Shigeo Koyasu

JOURNAL OF IMMUNOLOGY　Vol. 191　No. 4　p. 1818-1826　2013/08　Research paper (scientific journal)

Th2-type innate immune responses mediated by natural helper cells

Shigeo Koyasu, Kazuyo Moro

Annals of the New York Academy of Sciences　Vol. 1283　No. 1　p. 43-49　2013　Research paper (scientific journal)

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Keisuke Nagao, Tetsuro Kobayashi, Kazuyo Moro, Manabu Ohyama, Takeya Adachi, Daniela Y Kitashima, Satoshi Ueha, Keisuke Horiuchi, Hideaki Tanizaki, Kenji Kabashima, Akiharu Kubo, Young-hun Cho, Björn E Clausen, Kouji Matsushima, Makoto Suematsu, Glaucia C Furtado, Sergio A Lira, Joshua M Farber, Mark C Udey, Masayuki Amagai

Nature Immunology　Vol. 13　No. 8　p. 744-752　2012/06　Research paper (scientific journal)

Natural "Helper" Cells in the Lung: Good or Bad Help?

Shigeo Koyasu, Kazuyo Moro

IMMUNITY　Vol. 36　No. 3　p. 317-319　2012/03

Role of innate lymphocytes in infection and inflammation

Shigeo Koyasu, Kazuyo Moro

FRONTIERS IN IMMUNOLOGY　Vol. 3　2012

Innate Th2-type immune responses and the natural helper cell, a newly identified lymphocyte population

Shigeo Koyasu, Kazuyo Moro

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 11　No. 2　p. 109-114　2011/04

Type 2 innate immune responses and the natural helper cell

Shigeo Koyasu, Kazuyo Moro

IMMUNOLOGY　Vol. 132　No. 4　p. 475-481　2011/04

[Identification of natural helper cell].

Moro K, Koyasu S

Arerugi = [Allergy]　Vol. 59　No. 7　p. 810-814　2010/07

Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells

Kazuyo Moro, Taketo Yamada, Masanobu Tanabe, Tsutomu Takeuchi, Tomokatsu Ikawa, Hiroshi Kawamoto, Jun-ichi Furusawa, Masashi Ohtani, Hideki Fujii, Shigeo Koyasu

NATURE　Vol. 463　No. 7280　p. 540-U160　2010/01　Research paper (scientific journal)

Natural Helper Cells: A New Player in the Innate Immune Response against Helminth Infection

Shigeo Koyasu, Kazuyo Moro, Masanobu Tanabe, Tsutomu Takeuchi

ADVANCES IN IMMUNOLOGY, VOL 108　Vol. 108　p. 21-44　2010　Part of collection (book)

粘膜免疫 粘膜免疫系に特徴的な細胞群とその機能 脂肪組織関連のナチュラルヘルパー細胞によるTh2サイトカインの先天産生(Innate production of Th2 cytokines by adipose tissue-associated natural helper cell)

茂呂 和世, 山田 健人, 伊川 友活, 河本 宏, 藤猪 英樹, 小安 重夫

日本免疫学会総会・学術集会記録　Vol. 39　p. 39-39　2009/11

SL2 自然免疫反応でTh2サイトカインを発現する新しいリンパ球(第59回日本アレルギー学会秋季学術大会)

小安 重夫, 茂呂 和世

アレルギー　Vol. 58　No. 8　p. 1023-1023　2009

Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis

Shigenori Nagai, Hitomi Mimuro, Taketo Yamada, Yukiko Baba, Kazuyo Moro, Tomonori Nochi, Hiroshi Kiyono, Toshihiko Suzuki, Chihiro Sasakawa, Shigeo Koyasu

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 21　p. 8971-8976　2007/05　Research paper (scientific journal)

Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles

S Nonaka, T Naito, H Chen, M Yamamoto, K Moro, H Kiyono, H Hamada, H Ishikawa

JOURNAL OF IMMUNOLOGY　Vol. 174　No. 4　p. 1906-1912　2005/02　Research paper (scientific journal)