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Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles
Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, Takayuki Shima, Shuhei Nakamura, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Tamotsu Yoshimori, Hideki Mochizuki
Proceedings of the National Academy of Sciences Vol. 121 No. 1 2023/12/26 Research paper (scientific journal)
Publisher: Proceedings of the National Academy of Sciences
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Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka
Acta neuropathologica Vol. 145 No. 5 p. 573-595 2023/03/20 Research paper (scientific journal)
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Therapeutic effect of TTR siRNA on hereditary transthyretin amyloidosis (ATTRv) nephropathy.
Takahiro Ajiki, Tatsuhiko Ozono, Fusako Sera, Hiroaki Yonishi, Jun Matsuda, César Aguirre, Keita Kakuda, Yumiko Yasuhara, Yoshitaka Isaka, Yasushi Sakata, Kensuke Ikenaka, Hideki Mochizuki
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis p. 1-8 2025/02/23 Research paper (scientific journal)
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Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Hiroki Ueda, Tomoki Mitani, Kosei Yamaura, Rikuhiro Yamada, Katsuhiko Matsumoto, Etsuo Susaki, Naruhiko Sahara, Rin Yanai, Kensuke Ikenaka, Shiying Jiang, Hideki Hayakawa, Hideki Mochizuki, Kousuke Baba
2025/02/11
Publisher: Springer Science and Business Media LLC
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TDP-43 transports ferritin heavy chain mRNA to regulate oxidative stress in neuronal axons
Jyunki Jinno, Rehab F. Abdelhamid, Junko Morita, Ryoko Saga, Yusuke Yamasaki, Atsushi Kadowaki, Kotaro Ogawa, Yasuyoshi Kimura, Kensuke Ikenaka, Goichi Beck, Kousuke Baba, Yoshitaka Nagai, Emiko Kasahara, Atsuo Sekiyama, Tasuku Hirayama, Isao Hozumi, Tatsuya Hasegawa, Toshiyuki Araki, Hideki Mochizuki, Seiichi Nagano
Neurochemistry International p. 105934-105934 2025/01 Research paper (scientific journal)
Publisher: Elsevier BV
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Evaluation of motor fluctuations in Parkinson’s disease: electronic vs. conventional paper diaries
Kanako Asai, Sayo Kawahara, Emi Shirahata, Kimihiro Iwasaki, Hikoichiro Nakai, Yuta Kajiyama, Seira Taniguchi, Lindun Ge, Keita Kakuda, Yasuyoshi Kimura, Tadashi Miyahara, Hiroki R. Ueda, Kensuke Ikenaka, Hideki Mochizuki
Frontiers in Neurology Vol. 15 2024/11/22 Research paper (scientific journal)
Publisher: Frontiers Media SA
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Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation
Hiroshi Sakiyama, Kousuke Baba, Yasuyoshi Kimura, Kotaro Ogawa, Ujiakira Nishiike, Hideki Hayakawa, Miki Yoshida, Cesar Aguirre, Kensuke Ikenaka, Seiichi Nagano, Hideki Mochizuki
Neurochemistry International p. 105906-105906 2024/11 Research paper (scientific journal)
Publisher: Elsevier BV
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New Insights into Freezing of Gait in Parkinson's Disease from Spectral Dynamic Causal Modeling.
Seira Taniguchi, Yuta Kajiyama, Takanori Kochiyama, Gajanan Revankar, Kotaro Ogawa, Emi Shirahata, Kana Asai, Chizu Saeki, Tatsuhiko Ozono, Yasuyoshi Kimura, Kensuke Ikenaka, Nicholas D'Cruz, Moran Gilat, Alice Nieuwboer, Hideki Mochizuki
Movement disorders : official journal of the Movement Disorder Society 2024/09/18 Research paper (scientific journal)
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Deciphering social traits and pathophysiological conditions from natural behaviors in common marmosets.
Takaaki Kaneko, Jumpei Matsumoto, Wanyi Lu, Xincheng Zhao, Louie Richard Ueno-Nigh, Takao Oishi, Kei Kimura, Yukiko Otsuka, Andi Zheng, Kensuke Ikenaka, Kousuke Baba, Hideki Mochizuki, Hisao Nishijo, Ken-Ichi Inoue, Masahiko Takada
Current biology : CB Vol. 34 No. 13 p. 2854-2867 2024/07/08 Research paper (scientific journal)
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The validation of a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q).
Seira Taniguchi, Kohei Marumoto, Yuta Kajiyama, Gajanan Revankar, Michiko Inoue, Hiroshi Yamamoto, Rika Kayano, Eiji Mizuta, Ryuichi Takahashi, Emi Shirahata, Chizu Saeki, Tatsuhiko Ozono, Yasuyoshi Kimura, Kensuke Ikenaka, Hideki Mochizuki
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2024/02/22 Research paper (scientific journal)
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Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Kensuke Ikenaka, Yuta Kajiyama, César Aguirre, Chi‐Jing Choong, Seira Taniguchi, Junko Doi, Nan Wang, Takahiro Ajiki, Kotaro Ogawa, Keita Kakuda, Yasuyoshi Kimura, Hideki Mochizuki
Pharmacology Research & Perspectives Vol. 12 No. 1 2024/01/29 Research paper (scientific journal)
Publisher: Wiley
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Successful treatment of seronegative immune‐mediated necrotizing myopathy developing during pregnancy: A case report and literature review
Yuto Hayashi, Tatsuhiko Ozono, Goichi Beck, Yuki Yonenobu, Rika Yamashita, Kensuke Ikenaka, Tatsusada Okuno, Shigeo Murayama, Hideki Mochizuki
Neurology and Clinical Neuroscience 2023/10/30 Research paper (scientific journal)
Publisher: Wiley
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Establishing an AI-based evaluation system that quantifies social/pathophysiological behaviors of common marmosets
Takaaki Kaneko, Jumpei Matsumoto Matsumoto, Wanyi Lu, Xincheng Zhao, Louie Richard Ueno-Nigh, Takao Oishi, Kei Kimura, Yukiko Otsuka, Andi Zheng, Kensuke Ikenaka, Kousuke Baba, Hideki Mochizuki, Hisao Nishijo, Ken-ichi Inoue, Masahiko Takada
2023/10/17
Publisher: Cold Spring Harbor Laboratory
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Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane.
Naohito Ito, Mayumi Tsuji, Naoki Adachi, Shiro Nakamura, Avijite Kumer Sarkar, Kensuke Ikenaka, César Aguirre, Atsushi Michael Kimura, Yuji Kiuchi, Hideki Mochizuki, David B Teplow, Kenjiro Ono
NPJ Parkinson's disease Vol. 9 No. 1 p. 139-139 2023/09/28 Research paper (scientific journal)
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Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura
Proceedings of the National Academy of Sciences of the United States of America Vol. 120 No. 39 2023/09/26 Research paper (scientific journal)
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レボドパ製剤により薬疹をきたしたパーキンソン病の一例
渡邊 慶, 西川 徹, 池中 建介, 杉山 慎太郎, 木下 允, 藤永 貴大, 江村 拓人, 谷 直樹, 貴島 晴彦, 望月 秀樹
臨床神経学 Vol. 63 No. 8 p. 554-554 2023/08
Publisher: (一社)日本神経学会
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パーキンソン病における半自動化嗅覚測定の有効性
田中 碧, 梶山 裕太, 小河 浩太郎, 角田 渓太, 木村 康義, 池中 建介, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 17回 p. 108-108 2023/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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先を見据えた早期パーキンソン病運動症状への薬物療法
池中 建介, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 17回 p. 68-68 2023/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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マンガン造影MRI法を用いた外因性微粒子の脳への伝播様式の検討
木村 康義, 小山内 実, 小牧 裕司, 早川 英規, 上村 優輝, 松下 知佳, 長谷川 直樹, 池中 建介, 馬場 孝輔, 瀬戸 章文, 虫明 元, 華山 力成, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 17回 p. 74-74 2023/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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パーキンソン病における半自動化嗅覚測定の有効性
田中 碧, 梶山 裕太, 小河 浩太郎, 角田 渓太, 木村 康義, 池中 建介, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 17回 p. 108-108 2023/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor
Lianjie Zhou, Touko Hajiri, Kichitaro Nakajima, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi
ACS Sensors 2023/06/26 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
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COVID-19罹患後に四肢筋力低下を認めた一例
古谷 祥吾, 大薗 達彦, 嶋津 歩, 池中 建介, 別宮 豪一, 村山 繁雄, 望月 秀樹
臨床神経学 Vol. 63 No. 6 p. 403-403 2023/06
Publisher: (一社)日本神経学会
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COVID-19罹患後に四肢筋力低下を認めた一例
古谷 祥吾, 大薗 達彦, 嶋津 歩, 池中 建介, 別宮 豪一, 村山 繁雄, 望月 秀樹
臨床神経学 Vol. 63 No. 6 p. 403-403 2023/06
Publisher: (一社)日本神経学会
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RNA interference in late-stage hereditary transthyretin amyloidosis: a clinicopathological study
Goichi Beck, Yuki Yonenobu, Makiko Kawai, Kensuke Ikenaka, Fusako Sera, Tatsuhiko Ozono, Yuki Shimada, Rika Yamashita, Yasushi Sakata, Eiichi Morii, Tsuneaki Yoshinaga, Yukio Ando, Shigeo Murayama, Hideki Mochizuki
Journal of Neurology 2023/05/08 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Extracellular transportation of α-synuclein by HLA class II molecules
Tatsuhiko Ozono, Yasuyoshi Kimura, Tadahiro Suenaga, Goichi Beck, Jyunki Jinno, César Aguirre, Kensuke Ikenaka, Dimitri Krainc, Hideki Mochizuki, Hisashi Arase
Biochemical and Biophysical Research Communications Vol. 644 p. 25-33 2023/02 Research paper (scientific journal)
Publisher: Elsevier BV
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An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau
Goichi Beck, Rika Yamashita, Kansuke Kido, Kensuke Ikenaka, Tomoya Chiba, Yuki Yonenobu, Yuko Saito, Eiichi Morii, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki
Neuropathology 2023/01/02 Research paper (scientific journal)
Publisher: Wiley
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視床梗塞後ジストニアに対して定位的ラジオ波視床破壊術を行った1例
石内 崇勝, 細見 晃一, 中村 元紀, 押野 悟, 谷 直樹, 森 信彦, 池中 建介, 梶山 裕太, 江村 拓人, 小野田 祐司, クー・ウイミン, 何 馨, 宇川 義一, 望月 秀樹, 貴島 晴彦
日本定位・機能神経外科学会プログラム・抄録集 Vol. 62回 p. 140-140 2023/01
Publisher: (一社)日本定位・機能神経外科学会
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Decreased cerebrospinal fluid orexin levels not associated with clinical sleep disturbance in Parkinson’s disease: A retrospective study
Takuya Ogawa, Claudio Liguori, Yuta Kajiyama, Hideaki Ishido, Shigeru Chiba, Gajanan S. Revankar, Tomohito Nakano, Seira Taniguchi, Takashi Kanbayashi, Kensuke Ikenaka, Hideki Mochizuki
PLOS ONE Vol. 17 No. 12 p. e0279747-e0279747 2022/12/30 Research paper (scientific journal)
Publisher: Public Library of Science (PLoS)
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Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto
Nature communications Vol. 13 No. 1 p. 5689-5689 2022/10/02 Research paper (scientific journal)
Publisher: Cold Spring Harbor Laboratory
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未来を切り開く脳神経科学の新技術 超音波制御型アミロイド増幅装置HANABIを用いたαシヌクレイン関連疾患の病態解明
池中 建介, Cesar Aguirre, 望月 秀樹
臨床神経学 Vol. 62 No. Suppl. p. S79-S79 2022/10
Publisher: (一社)日本神経学会
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Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.
Noriko Nishikawa, Miho Murata, Taku Hatano, Yohei Mukai, Yuji Saitoh, Takashi Sakamoto, Takashi Hanakawa, Yuichi Kamei, Hisateru Tachimori, Kenji Hatano, Hiroshi Matsuda, Yosuke Taruno, Nobukatsu Sawamoto, Yuta Kajiyama, Kensuke Ikenaka, Kazuya Kawabata, Tomohiko Nakamura, Hirotaka Iwaki, Hiroshi Kadotani, Yukiyoshi Sumi, Yuichi Inoue, Toshihiro Hayashi, Takeshi Ikeuchi, Yasushi Shimo, Hideki Mochizuki, Hirohisa Watanabe, Nobutaka Hattori, Yuji Takahashi, Ryosuke Takahashi
Parkinsonism & related disorders Vol. 103 p. 129-135 2022/10 Research paper (scientific journal)
Publisher: Elsevier BV
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Ischemic Stroke Due to Heparin-induced Thrombocytopenia during Severe COVID-19 Infection.
Yasutaka Murakami, Shuhei Okazaki, Makoto Yamamoto, Rei Sakurai, Jyunki Jinno, Tatsuhiko Ozono, Kensuke Ikenaka, Yasufumi Gon, Kenichi Todo, Tsutomu Sasaki, Haruhiko Hirata, Akinori Uchiyama, Hideki Mochizuki
Internal medicine (Tokyo, Japan) Vol. 61 No. 18 p. 2797-2801 2022/09/15 Research paper (scientific journal)
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α-シヌクレインの異常凝集を誘導する脂質の解析
角田 渓太, Choong Chi-Jing, Aguirre Cesar, 土居 純子, 木村 康義, 池中 建介, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 16回 p. 84-84 2022/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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パーキンソン病モデルマウスにおける異常老化がα-synucleinopathyを促進する
佐木山 裕史, 早川 英規, 木村 康義, Aguirre Cesar, 池中 建介, 長野 清一, 馬場 孝輔, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 16回 p. 85-85 2022/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
Yukako Oe, Keita Kakuda, Shin-Ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura
PLoS genetics Vol. 18 No. 6 2022/06 Research paper (scientific journal)
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Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
Kensuke Ikenaka, Yasuhiro Maeda, Yuji Hotta, Seiichi Nagano, Shinichiro Yamada, Daisuke Ito, Ryota Torii, Keita Kakuda, Harutsugu Tatebe, Naoki Atsuta, Cesar Aguirre, Yasuyoshi Kimura, Kousuke Baba, Takahiko Tokuda, Masahisa Katsuno, Kazunori Kimura, Gen Sobue, Hideki Mochizuki
European journal of neurology Vol. 29 No. 5 p. 1410-1416 2022/05/29 Research paper (scientific journal)
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Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020
M.D., Ph.D. Mochizuki Hideki, M.D., Ph.D. Aoki Masashi, M.D., Ph.D. Ikenaka Kensuke, M.D., Ph.D. Inoue Haruhisa, M.D., Ph.D. Iwatsubo Takeshi, M.D., Ph.D. Ugawa Yoshikazu, M.D., Ph.D. Okazawa Hitoshi, M.D., Ph.D. Ono Kenjiro, M.D., Ph.D. Onodera Osamu, M.D., Ph.D. Kitagawa Kazuo, M.D., Ph.D. Saito Yuko, M.D., Ph.D. Shimohata Takayoshi, M.D., Ph.D. Takahashi Ryosuke, M.D., Ph.D. Toda Tatsushi, M.D., Ph.D. Nakahara Jin, M.D., Ph.D. Matsumoto Riki, M.D., Ph.D. Mizusawa Hidehiro, M.D., Ph.D. Mitsui Jun, M.D., Ph.D. Murayama Shigeo, M.D., Ph.D. Katsuno Masahisa, the Future Vision Committee of Japanese Society of Neurology, M.D., Ph.D. Aoki Yoshitsugu, M.D., Ph.D. Ishiura Hiroyuki, M.D., Ph.D. Izumi Yuishin, M.D., Ph.D. Koike Haruki, M.D., Ph.D. Shimada Hitoshi, M.D., Ph.D. Takahashi Yuji, M.D., Ph.D. Tokuda Takahiko, M.D., Ph.D. Nakajima Hideto, M.D., Ph.D. Hatano Taku, M.D., Ph.D. Misawa Sonoko, M.D., Ph.D. Watanabe Hirohisa
Rinsho Shinkeigaku Vol. advpub 2022/05
Publisher: Societas Neurologica Japonica
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Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020
M.D., Ph.D. Mochizuki Hideki, M.D., Ph.D. Aoki Masashi, M.D., Ph.D. Ikenaka Kensuke, M.D., Ph.D. Inoue Haruhisa, M.D., Ph.D. Iwatsubo Takeshi, M.D., Ph.D. Ugawa Yoshikazu, M.D., Ph.D. Okazawa Hitoshi, M.D., Ph.D. Ono Kenjiro, M.D., Ph.D. Onodera Osamu, M.D., Ph.D. Kitagawa Kazuo, M.D., Ph.D. Saito Yuko, M.D., Ph.D. Shimohata Takayoshi, M.D., Ph.D. Takahashi Ryosuke, M.D., Ph.D. Toda Tatsushi, M.D., Ph.D. Nakahara Jin, M.D., Ph.D. Matsumoto Riki, M.D., Ph.D. Mizusawa Hidehiro, M.D., Ph.D. Mitsui Jun, M.D., Ph.D. Murayama Shigeo, M.D., Ph.D. Katsuno Masahisa, the Future Vision Committee of Japanese Society of Neurology, M.D., Ph.D. Aoki Yoshitsugu, M.D., Ph.D. Ishiura Hiroyuki, M.D., Ph.D. Izumi Yuishin, M.D., Ph.D. Koike Haruki, M.D., Ph.D. Shimada Hitoshi, M.D., Ph.D. Takahashi Yuji, M.D., Ph.D. Tokuda Takahiko, M.D., Ph.D. Nakajima Hideto, M.D., Ph.D. Hatano Taku, M.D., Ph.D. Misawa Sonoko, M.D., Ph.D. Watanabe Hirohisa
Rinsho Shinkeigaku Vol. advpub 2022/05
Publisher: Societas Neurologica Japonica
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Senataxin(SETX)遺伝子バリアントを認めた孤発性amyotrophic lateral sclerosis(ALS)の1例
別府 祥平, 池中 建介, 藪本 大紀, 藤堂 謙一, 橋口 昭大, 高嶋 博, 望月 秀樹
臨床神経学 Vol. 62 No. 3 p. 205-210 2022/03
Publisher: (一社)日本神経学会
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piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis.
Rehab F Abdelhamid, Kotaro Ogawa, Goichi Beck, Kensuke Ikenaka, Eriko Takeuchi, Yoshiaki Yasumizu, Jyunki Jinno, Yasuyoshi Kimura, Kousuke Baba, Yoshitaka Nagai, Yukinori Okada, Yuko Saito, Shigeo Murayama, Hideki Mochizuki, Seiichi Nagano
Molecular neurobiology Vol. 59 No. 3 p. 1693-1705 2022/03 Research paper (scientific journal)
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[A case of sporadic amyotrophic lateral sclerosis (ALS) with Senataxin (SETX) gene variant].
Shohei Beppu, Kensuke Ikenaka, Taiki Yabumoto, Kenichi Todo, Akihiro Hashiguchi, Hiroshi Takashima, Hideki Mochizuki
Rinsho shinkeigaku = Clinical neurology 2022/02/25 Research paper (scientific journal)
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Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs
Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki
bioRxiv 2022/02/10 Research paper (scientific journal)
Publisher: Cold Spring Harbor Laboratory
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Development of HANABI, an ultrasonication-forced amyloid fibril inducer.
Yuji Goto, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi
Neurochemistry international Vol. 153 p. 105270-105270 2022/02 Research paper (scientific journal)
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Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.
Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka
Scientific reports Vol. 12 No. 1 p. 351-351 2022/01/10 Research paper (scientific journal)
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Acceleration of amyloid fibril formation by multichannel sonochemical reactor
Kentaro Noi, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu OGI
Japanese Journal of Applied Physics 2021/12/08 Research paper (scientific journal)
Publisher: IOP Publishing
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Breakdown of supersaturation barrier links protein folding to amyloid formation
Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto
Communications Biology Vol. 4 No. 1 p. 120-120 2021/12 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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PACSIN1は基底オートファジー、リソファジーにおけるアンフィソーム・リソソーム間融合に必須である
大江 由佳子, 吉村 信一郎, 木村 康義, 池中 建介, 望月 秀樹, 中村 修平, 吉森 保
日本生化学会大会プログラム・講演要旨集 Vol. 94回 p. [2T13a-479)] 2021/11
Publisher: (公社)日本生化学会
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1Pa4-5 Accelerating amyloid fibril formation by multi-channel ultrasonic chemical reactor
Noi Kentaro, Nakajima Kichitaro, Yamaguchi Keiichi, So Masatomo, Ikenaka Kensuke, Mochizuki Hideki, Goto Yuji, Ogi Hirotugu
Proceedings of Symposium on Ultrasonic Electronics Vol. 42 2021/10/25
Publisher: Institute for Ultrasonic Elecronics
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[Recommendations (Proposal) for promoting research for overcoming neurological diseases 2020].
Hideki Mochizuki, Masashi Aoki, Kensuke Ikenaka, Haruhisa Inoue, Takeshi Iwatsubo, Yoshikazu Ugawa, Hitoshi Okazawa, Kenjiro Ono, Osamu Onodera, Kazuo Kitagawa, Yuko Saito, Takayoshi Shimohata, Ryosuke Takahashi, Tatsushi Toda, Jin Nakahara, Riki Matsumoto, Hidehiro Mizusawa, Jun Mitsui, Shigeo Murayama, Masahisa Katsuno, Yoshitsugu Aoki, Hiroyuki Ishiura, Yuishin Izumi, Haruki Koike, Hitoshi Shimada, Yuji Takahashi, Takahiko Tokuda, Hideto Nakajima, Taku Hatano, Sonoko Misawa, Hirohisa Watanabe
Rinsho shinkeigaku = Clinical neurology Vol. 61 No. 11 p. 709-721 2021/10/16 Research paper (scientific journal)
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Strong acids induce amyloid fibril formation of β2-microglobulin via an anion-binding mechanism.
Keiichi Yamaguchi, Kenshiro Hasuo, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto
The Journal of biological chemistry Vol. 297 No. 5 p. 101286-101286 2021/10/06 Research paper (scientific journal)
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Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction.
Kichitaro Nakajima, Hajime Toda, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi
ACS chemical neuroscience Vol. 12 No. 18 p. 3456-3466 2021/09/15 Research paper (scientific journal)
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Disaggregation Behavior of Amyloid β Fibrils by Anthocyanins Studied by Total-Internal-Reflection-Fluorescence Microscopy Coupled with a Wireless Quartz-Crystal Microbalance Biosensor
Kentaro Noi, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi
Analytical Chemistry 2021/08/05 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
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Polyphenol-solubility alters amyloid fibril formation of α-synuclein.
Masatomo So, Yuto Kimura, Keiichi Yamaguchi, Toshihiko Sugiki, Toshimichi Fujiwara, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto
Protein science : a publication of the Protein Society Vol. 30 No. 8 p. 1701-1713 2021/05/27 Research paper (scientific journal)
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Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation
Kichitaro Nakajima, Kentaro Noi, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi, Yuji Goto
Ultrasonics Sonochemistry Vol. 73 p. 105508-105508 2021/05 Research paper (scientific journal)
Publisher: Elsevier BV
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Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners.
Keiichi Yamaguchi, Masatomo So, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto
The Journal of biological chemistry p. 100510-100510 2021/03/04 Research paper (scientific journal)
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Alternative mitochondrial quality control mediated by extracellular release
Chi-Jing Choong, Tatsusada Okuno, Kensuke Ikenaka, Kousuke Baba, Hideki Hayakawa, Masato Koike, Mutsumi Yokota, Junko Doi, Keita Kakuda, Toshihide Takeuchi, Akiko Kuma, Shuhei Nakamura, Yoshitaka Nagai, Seiichi Nagano, Tamotsu Yoshimori, Hideki Mochizuki
Autophagy Vol. 17 No. 10 p. 1-13 2020/12/10 Research paper (scientific journal)
Publisher: Informa UK Limited
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Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System
Shiying Jiang, Kousuke Baba, Tatsusada Okuno, Makoto Kinoshita, Chi-Jing Choong, Hideki Hayakawa, Hiroshi Sakiyama, Kensuke Ikenaka, Seiichi Nagano, Tsutomu Sasaki, Munehisa Shimamura, Yoshitaka Nagai, Keisuke Hagihara, Hideki Mochizuki
Neurotherapeutics Vol. 18 No. 1 p. 460-473 2020/10/20 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Two New Polymorphs in H50Q Determined by CryoEM Suggest a Mechanism That Explains Its Faster Kinetics In Vitro
Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki
Movement Disorders Vol. 35 No. 6 p. 935-936 2020/06 Research paper (scientific journal)
Publisher: Wiley
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Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism
Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto
Current Research in Structural Biology Vol. 2 p. 35-44 2020/04/05 Research paper (scientific journal)
Publisher: Elsevier BV
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Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Kensuke Ikenaka, Shinsuke Ishigaki, Yohei Iguchi, Kaori Kawai, Yusuke Fujioka, Satoshi Yokoi, Rehab F Abdelhamid, Seiichi Nagano, Hideki Mochizuki, Masahisa Katsuno, Gen Sobue
Journal of neuropathology and experimental neurology Vol. 79 No. 4 p. 370-377 2020/04/01 Research paper (scientific journal)
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Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.
Hideki Hayakawa, Rie Nakatani, Kensuke Ikenaka, Cesar Aguirre, Chi-Jing Choong, Hiroshi Tsuda, Seiichi Nagano, Masato Koike, Takeshi Ikeuchi, Masato Hasegawa, Stella M Papa, Yoshitaka Nagai, Hideki Mochizuki, Kousuke Baba
Movement disorders : official journal of the Movement Disorder Society Vol. 35 No. 2 p. 256-267 2020/02 Research paper (scientific journal)
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A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy.
Hideshima M, Beck G, Yamadera M, Motoyama Y, Ikenaka K, Kakuda K, Tsuda H, Nagano S, Fujimura H, Morii E, Murayama S, Mochizuki H
Neuropathology : official journal of the Japanese Society of Neuropathology Vol. 40 No. 2 p. 191-195 2019/12
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MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.
Yabumoto T, Yoshida F, Miyauchi H, Baba K, Tsuda H, Ikenaka K, Hayakawa H, Koyabu N, Hamanaka H, Papa SM, Hirata M, Mochizuki H
Journal of neuroscience methods Vol. 322 p. 23-33 2019/07 Research paper (scientific journal)
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A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease.
Ikenaka K, Tsukada Y, Giles AC, Arai T, Nakadera Y, Nakano S, Kawai K, Mochizuki H, Katsuno M, Sobue G, Mori I
Scientific reports Vol. 9 No. 1 2019/07
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Increase of arginine dimethylation correlates with the progression and prognosis of ALS.
Kensuke Ikenaka, Naoki Atsuta, Yasuhiro Maeda, Yuji Hotta, Ryoichi Nakamura, Kaori Kawai, Daichi Yokoi, Akihiro Hirakawa, Akira Taniguchi, Mitsuya Morita, Kouichi Mizoguchi, Hideki Mochizuki, Kazunori Kimura, Masahisa Katsuno, Gen Sobue
Neurology Vol. 92 No. 16 p. e1868-e1877-e1877 2019/04/16 Research paper (scientific journal)
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Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.
Keita Kakuda, Kensuke Ikenaka, Katsuya Araki, Masatomo So, César Aguirre, Yuta Kajiyama, Kuni Konaka, Kentaro Noi, Kousuke Baba, Hiroshi Tsuda, Seiichi Nagano, Takuma Ohmichi, Yoshitaka Nagai, Takahiko Tokuda, Omar M A El-Agnaf, Hirotsugu Ogi, Yuji Goto, Hideki Mochizuki
Scientific reports Vol. 9 No. 1 p. 6001-6001 2019/04/12 Research paper (scientific journal)
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[Analysis of PEG-J associated complications in 14 adult patients treated with levodopa-carbidopa intestinal gel].
Munehisa Shimamura, Shinichiro Shinzaki, Kensuke Ikenaka, Kuni Konaka, Daisuke Hirozawa, Teruyuki Ishikura, Makoto Hideshima, Tomohito Nakano, Takaya Kitano, Tetsuo Takehara, Hideki Mochizuki
Rinsho shinkeigaku = Clinical neurology Vol. 59 No. 3 p. 153-156 2019/03/28 Research paper (scientific journal)
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Suppression of autophagic activity by Rubicon is a signature of aging.
Shuhei Nakamura, Masaki Oba, Mari Suzuki, Atsushi Takahashi, Tadashi Yamamuro, Mari Fujiwara, Kensuke Ikenaka, Satoshi Minami, Namine Tabata, Kenichi Yamamoto, Sayaka Kubo, Ayaka Tokumura, Kanako Akamatsu, Yumi Miyazaki, Tsuyoshi Kawabata, Maho Hamasaki, Koji Fukui, Kazunori Sango, Yoshihisa Watanabe, Yoshitsugu Takabatake, Tomoya S Kitajima, Yukinori Okada, Hideki Mochizuki, Yoshitaka Isaka, Adam Antebi, Tamotsu Yoshimori
Nature communications Vol. 10 No. 1 p. 847-847 2019/02/19 Research paper (scientific journal)
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Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson's Disease.
Ikenaka K, Suzuki M, Mochizuki H, Nagai Y
Frontiers in neuroscience Vol. 13 2019
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[Levodopa-carbidopa intestinal gel treatment introduced by surgical gastrostomy in a patient of Parkinson's disease after Billroth II gastrojejunostomy].
Nakano T, Hirozawa D, Shimamura M, Sasaki T, Ikenaka K, Mochizuki H
Rinsho shinkeigaku = Clinical neurology Vol. 58 No. 9 p. 570-573 2018/09
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迅速化凝集アッセイと線虫モデルの組み合わせによるシヌクレイン凝集阻害薬スクリーニング
池中 建介, 角田 渓太, 馬場 孝輔, 荒木 克哉, 武内 敏秀, 園田 静夏, 永井 義隆, 後藤 祐児, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 12回 p. 74-74 2018/07
Publisher: Movement Disorder Society of Japan (MDSJ)
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髄液中αsynuclein凝集体測定による新規パーキンソン病バイオマーカーの開発
角田 渓太, 池中 建介, 荒木 克哉, 梶山 裕太, 宗 正智, 後藤 祐児, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 11回 p. 68-68 2017/10
Publisher: Movement Disorder Society of Japan (MDSJ)
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Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes
Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi, Yohei Iguchi, Naruhiko Sahara, Akihiko Takashima, Hideyuki Okano, Mari Yoshida, Hitoshi Warita, Masashi Aoki, Hirohisa Watanabe, Haruo Okado, Masahisa Katsuno, Gen Sobue
CELL REPORTS Vol. 18 No. 5 p. 1118-1131 2017/01 Research paper (scientific journal)
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シヌクレイン凝集阻害薬の大規模スクリーニング系の開発
池中 建介, 荒木 克哉, 薮本 大紀, Choong Chi-Jing, 早川 英規, 宗 正智, 馬場 孝介, 橋本 真一, 長野 清一, 永井 義隆, 後藤 祐児, 望月 秀樹
パーキンソン病・運動障害疾患コングレスプログラム・抄録集 Vol. 10回 p. 85-85 2016/10
Publisher: Movement Disorder Society of Japan (MDSJ)
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dynactin-1ノックアウトマウスにおける進行性運動機能障害
河合 香里, 池中 建介, 勝野 雅央, 井口 洋平, 田中 章景, 祖父江 元
神経治療学 Vol. 32 No. 5 p. 839-839 2015/09
Publisher: (一社)日本神経治療学会
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Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors
Madoka Iida, Masahisa Katsuno, Hideaki Nakatsuji, Hiroaki Adachi, Naohide Kondo, Yu Miyazaki, Genki Tohnai, Kensuke Ikenaka, Hirohisa Watanabe, Masahiko Yamamoto, Ken Kishida, Gen Sobue
HUMAN MOLECULAR GENETICS Vol. 24 No. 2 p. 314-329 2015/01 Research paper (scientific journal)
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dynactin-1ノックアウトマウスを用いた孤発性ALSの病態解析
河合 香里, 池中 建介, 勝野 雅央, 井口 洋平, 勝又 竜, 田中 章景, 祖父江 元
臨床神経学 Vol. 54 No. Suppl. p. S100-S100 2014/12
Publisher: (一社)日本神経学会
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Cutaneous arteritis associated with peripheral neuropathy: Two case reports
Yuichi Riku, Kensuke Ikenaka, Haruki Koike, Yoshiki Niimi, Jo Senda, Rina Hashimoto, Yuichi Kawagashira, Minoru Tomita, Masahiro Iijima, Gen Sobue
JOURNAL OF DERMATOLOGY Vol. 41 No. 3 p. 266-267 2014/03
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dynactin-1ノックアウトによる孤発性ALSモデルマウスの作成と病態解析
河合 香里, 池中 建介, 勝野 雅央, 井口 洋平, 勝又 竜, 田中 章景, 祖父江 元
臨床神経学 Vol. 53 No. 12 p. 1500-1500 2013/12
Publisher: (一社)日本神経学会
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Amyotrophic lateral sclerosis: an update on recent genetic insights
Yohei Iguchi, Masahisa Katsuno, Kensuke Ikenaka, Shinsuke Ishigaki, Gen Sobue
JOURNAL OF NEUROLOGY Vol. 260 No. 11 p. 2917-2927 2013/11 Research paper (scientific journal)
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RNP2 of RNA Recognition Motif 1 Plays a Central Role in the Aberrant Modification of TDP-43
Shinnosuke Takagi, Yohei Iguchi, Masahisa Katsuno, Shinsuke Ishigaki, Kensuke Ikenaka, Yusuke Fujioka, Daiyu Honda, Jun-ichi Niwa, Fumiaki Tanaka, Hirohisa Watanabe, Hiroaki Adachi, Gen Sobue
PLOS ONE Vol. 8 No. 6 2013/06 Research paper (scientific journal)
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Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
Yohei Iguchi, Masahisa Katsuno, Jun-ichi Niwa, Shinnosuke Takagi, Shinsuke Ishigaki, Kensuke Ikenaka, Kaori Kawai, Hirohisa Watanabe, Koji Yamanaka, Ryosuke Takahashi, Hidemi Misawa, Shoichi Sasaki, Fumiaki Tanaka, Gen Sobue
BRAIN Vol. 136 No. Pt 5 p. 1371-1382 2013/05 Research paper (scientific journal)
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dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration
Kensuke Ikenaka, Kaori Kawai, Masahisa Katsuno, Zhe Huang, Yue-Mei Jiang, Yohei Iguchi, Kyogo Kobayashi, Tsubasa Kimata, Masahiro Waza, Fumiaki Tanaka, Ikue Mori, Gen Sobue
PLOS ONE Vol. 8 No. 2 2013/02 Research paper (scientific journal)
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Dysfunction of dynactin 1 in motor neuron degeneration
Masahisa Katsuno, Kensuke Ikenaka, Kaori Kawai, Gen Sobue
Clinical Neurology Vol. 53 No. 11 p. 1084-1086 2013 Research paper (scientific journal)
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Neuropathology and omics in motor neuron diseases
Fumiaki Tanaka, Kensuke Ikenaka, Masahiko Yamamoto, Gen Sobue
NEUROPATHOLOGY Vol. 32 No. 4 p. 458-462 2012/08 Research paper (scientific journal)
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Disruption of Axonal Transport in Motor Neuron Diseases
Kensuke Ikenaka, Masahisa Katsuno, Kaori Kawai, Shinsuke Ishigaki, Fumiaki Tanaka, Gen Sobue
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 13 No. 1 p. 1225-1238 2012/01
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Role of axonal transport in ALS
Fumiaki Tanaka, Kensuke Ikenaka, Gen Sobue
Clinical Neurology Vol. 51 No. 11 p. 1189-1191 2011 Research paper (international conference proceedings)
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Immunohistochemical and western analyses of protein arginine N-methyltransferase 3 in the mouse brain
K. Ikenaka, S. Miyata, Y. Mori, Y. Koyama, T. Taneda, H. Okuda, A. Kousaka, M. Tohyama
NEUROSCIENCE Vol. 141 No. 4 p. 1971-1982 2006 Research paper (scientific journal)
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Local protein synthesis by BDNF is potentiated in hippocampal neurons exposed to ephrins
S Miyata, Y Mori, T Fujiwara, K Ikenaka, S Matsuzaki, K Oono, T Katayama, M Tohyama
MOLECULAR BRAIN RESEARCH Vol. 134 No. 2 p. 333-337 2005/04 Research paper (scientific journal)
