Researcher Directory - Osaka University

Mizuguchi Hiroyuki

水口　裕之

Graduate School of Pharmaceutical Sciences　Advanced Pharmaco-science, Professor

Education

- 1996, 大阪大学大学院, 薬学研究科
- 1996, Osaka University, Graduate School of Pharmaceutical Sciences, Pharmaceutics
- 1991, Osaka University, School of Pharmaceutical Sciences
- 1991, Osaka University, Faculty of Pharmaceutical Sciences

Research History

2015/04 - Present, 大阪大学国際医工情報センター教授（兼任）
2014/04 - Present, 国立研究開発法人医薬基盤・健康・栄養研究所肝細胞分化誘導ﾌﾟﾛｼﾞｪｸﾄ招へいﾌﾟﾛｼﾞｪｸﾄﾘｰﾀﾞｰ（兼任）
2008/10 - Present, 大阪大学大学院薬学研究科分子生物学分野教授
2010/11 - 2015/03, 大阪大学臨床医工学融合研究教育センター教授（兼任）
2013/04 - 2014/03, 独立行政法人医薬基盤研究所創薬基盤研究部肝細胞分化誘導ﾌﾟﾛｼﾞｪｸﾄ招へいﾌﾟﾛｼﾞｪｸﾄﾘｰﾀﾞｰ（併任）
2010/04 - 2013/03, 独立行政法人医薬基盤研究所創薬基盤研究部幹細胞制御ﾌﾟﾛｼﾞｪｸﾄﾁｰﾌﾌﾟﾛｼﾞｪｸﾄﾘｰﾀﾞｰ（併任）
2008/10 - 2010/03, 独立行政法人医薬基盤研究所基盤的研究部遺伝子導入制御ﾌﾟﾛｼﾞｪｸﾄﾌﾟﾛｼﾞｪｸﾄﾘｰﾀﾞｰ（併任）
2005/03 - 2008/09, 独立行政法人医薬基盤研究所基盤的研究部遺伝子導入制御ﾌﾟﾛｼﾞｪｸﾄﾌﾟﾛｼﾞｪｸﾄﾘｰﾀﾞｰ
2004/04 - 2005/03, 国立医薬品食品衛生研究所大阪支所基盤研究第3ﾌﾟﾛｼﾞｪｸﾄﾁｰﾑ副ﾌﾟﾛｼﾞｪｸﾄ長
2002/07 - 2004/03, 国立医薬品食品衛生研究所遺伝子細胞医薬部主任研究官
1998/07 - 2002/06, 国立医薬品食品衛生研究所生物薬品部研究員
1997/04 - 1998/06, 米国ワシントン大学Senior Fellow（1998年～日本学術研究会海外特別研究員）
1996/04 - 1997/03, 大阪大学微生物病研究所神経ウイルス分野研究員（日本学術振興会特別研究員PD）

Research Areas

Life sciences, Clinical pharmacy

Professional Memberships

International Society for Stem Cell Research
日本分子生物学学会
日本薬物動態学会
日本再生医療学会
肝細胞研究会
日本癌学会
日本DDS学会
日本薬学会
日本遺伝子細胞治療学会
アメリカ遺伝子細胞治療学会
The Japan Society of Gene Therapy

Papers

Overexpression of lysophospholipid acyltransferase, <scp>LPLAT10</scp>/<scp>LPCAT4</scp>/<scp>LPEAT2</scp>, in the mouse liver increases glucose‐stimulated insulin secretion, Kahori Shimizu,Moe Ono,Takenari Mikamoto,Yuya Urayama,Sena Yoshida,Tomomi Hase,Shotaro Michinaga,Hiroki Nakanishi,Miho Iwasaki,Tomoyuki Terada,Fuminori Sakurai,Hiroyuki Mizuguchi,Hideo Shindou,Koji Tomita,Toru Nishinaka, The FASEB Journal, Wiley, Vol. 38, No. 2, 2024/01/16
Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients, Sena Ikemoto,Fuminori Sakurai,Sora Tokuoka,Tomoki Yamashita,Kosuke Takayama,Kazuaki Hoshi,Takahiro Okabe,Issei Sumiyoshi,Shinsaku Togo,Kazuhisa Takahashi,Masashi Tachibana,Hiroyuki Mizuguchi, PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 10, p. e0286323-e0286323, 2023/10/19
Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation, Tomohiro Shintani,Chiharu Imamura,Yukiko Ueyama-Toba,Jumpei Inui,Akira Watanabe,Hiroyuki Mizuguchi, Molecular Therapy - Methods & Clinical Development, Elsevier BV, Vol. 30, p. 429-442, 2023/09
Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α, Takuma Hotani,Kanako Nakagawa,Tomohito Tsukamoto,Hiroyuki Mizuguchi,Fuminori Sakurai, Inflammation, Springer Science and Business Media LLC, 2023/08/24
miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells., Eiko Sakai,Tsutomu Imaizumi,Ruruka Suzuki,Marcos Taracena-Gándara,Toshiki Fujimoto,Fuminori Sakurai,Hiroyuki Mizuguchi, Communications biology, Vol. 6, No. 1, p. 669-669, 2023/06/24
Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging, Menglu Li,Yukiko Ueyama-Toba,Matthew Lindley,Gunganist Kongklad,Yasunori Nawa,Yasuaki Kumamoto,Seiichi Ishida,Yasunari Kanda,Satoshi Fujita,Hiroyuki Mizuguchi,Katsumasa Fujita, Analytical Chemistry, Vol. 95, No. 24, p. 9252-9262, 2023/06
Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture., Yanran Tong,Yukiko Ueyama-Toba,Hiroyuki Mizuguchi, Biochemistry and biophysics reports, Vol. 33, p. 101432-101432, 2023/03
Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism., Haoyang Zhou,Zhiqi Xie,Naosuke Morikawa,Fuminori Sakurai,Hiroyuki Mizuguchi,Daisuke Okuzaki,Naoki Okada,Masashi Tachibana, Biochemistry and biophysics reports, Vol. 33, p. 101416-101416, 2023/03
Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes., Maho Eguchi,Seiya Hirata,Ikuho Ishigami,Naomi Shuwari,Ryosuke Ono,Masashi Tachibana,Masato Tanuma,Atsushi Kasai,Hitoshi Hashimoto,Ken-Ichi Ogawara,Hiroyuki Mizuguchi,Fuminori Sakurai, Journal of controlled release : official journal of the Controlled Release Society, Vol. 354, p. 35-44, 2023/02
Treatment of Human Pancreatic Cancers Following Local and Systemic Administration of Oncolytic Adenovirus Serotype 35., Ryosuke Ono,Kosuke Takayama,Rika Onishi,Sora Tokuoka,Fuminori Sakurai,Hiroyuki Mizuguchi, Anticancer research, Vol. 43, No. 2, p. 537-546, 2023/02
Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions., Jumpei Inui,Yukiko Ueyama-Toba,Seiji Mitani,Hiroyuki Mizuguchi, PloS one, Vol. 18, No. 5, 2023
Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus., Ryosuke Ono,Fumitaka Nishimae,Takuro Wakida,Fuminori Sakurai,Hiroyuki Mizuguchi, Scientific reports, Vol. 12, No. 1, p. 21560-21560, 2022/12/13
Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice, Kahori Shimizu,Syogo Nishimuta,Yuri Fukumura,Shotaro Michinaga,Yuka Egusa,Tomomi Hase,Tomoyuki Terada,Fuminori Sakurai,Hiroyuki Mizuguchi,Koji Tomita,Toru Nishinaka, PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 9, p. e0274297-e0274297, 2022/09/13
A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine., Lin Bai,Keisuke Tachibana,Michika Murata,Tetsunori Inoue,Hiroyuki Mizuguchi,Shinichiro Maeda,Kenji Ikemura,Masahiro Okuda,Tetsuya Kusakabe,Masuo Kondoh, Toxicology letters, Vol. 370, p. 1-6, 2022/09/12
A dopamine antagonist, domperidone enhances the replication of an oncolytic adenovirus in human tumour cells., Fumitaka Nishimae,Fuminori Sakurai,Ryosuke Ono,Rika Onishi,Kosuke Takayama,Hiroyuki Mizuguchi, The Journal of general virology, Vol. 103, No. 6, 2022/06
Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment., Hiroshi Tazawa,Kunitoshi Shigeyasu,Kazuhiro Noma,Shunsuke Kagawa,Fuminori Sakurai,Hiroyuki Mizuguchi,Hisataka Kobayashi,Takeshi Imamura,Toshiyoshi Fujiwara, Cancer science, Vol. 113, No. 6, p. 1919-1929, 2022/06
Adenovirus Vector With ADP Gene Induces Cytopathic Effects in HEK293 Cells Without Significant Elevation of Virus Titers., Aoi Shiota,Fumitaka Nishimae,Fuminori Sakurai,Hiroyuki Mizuguchi, Anticancer research, Vol. 42, No. 4, p. 1719-1727, 2022/04
Label-free assessment of hiPS-derived hepatocytes by Raman microscopy, Menglu Li,Yukiko Toba,Yasunori Nawa,Satoshi Fujita,Hiroyuki Mizuguchi,Katsumasa Fujita, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, SPIE, Vol. 11957, 2022/03/02
レオウイルス感染がん細胞由来細胞外小胞の抗腫瘍効果に関する検討, 種昂なお実,井上智重子,神宮司健太郎,辻川和丈,水口裕之,櫻井文教, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 142年会, p. 27J-am01S, 2022/03
Adenovirus vector-based vaccine for infectious diseases., Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Drug metabolism and pharmacokinetics, Vol. 42, p. 100432-100432, 2021/11/12
Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts., Nozomi Kurisu,Tadataka Kaminade,Maho Eguchi,Ikuho Ishigami,Hiroyuki Mizuguchi,Fuminori Sakurai, International journal of pharmaceutics, p. 121269-121269, 2021/11/05
miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells., Jaeeun Lim,Eiko Sakai,Fuminori Sakurai,Hiroyuki Mizuguchi, Scientific reports, Vol. 11, No. 1, p. 19820-19820, 2021/10/06
Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies., Emi Sano,Sayaka Deguchi,Naoki Matsuoka,Masahiro Tsuda,Mengyang Wang,Kaori Kosugi,Chihiro Mori,Keisuke Yagi,Aya Wada,Shinsuke Yamasaki,Tsuyoshi Kawai,Masahide Yodogawa,Hiroyuki Mizuguchi,Norihito Nakazawa,Fumiyoshi Yamashita,Yu-Suke Torisawa,Kazuo Takayama, ACS omega, Vol. 6, No. 38, p. 24859-24865, 2021/09/28
Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research., Tomoki Yamashita,Tatsuya Inui,Jumpei Yokota,Kentaro Kawakami,Gaku Morinaga,Masahito Takatani,Daisuke Hirayama,Ryuga Nomoto,Kohei Ito,Yunhai Cui,Stephanie Ruez,Kazuo Harada,Wataru Kishimoto,Hiroshi Nakase,Hiroyuki Mizuguchi, Molecular therapy. Methods & clinical development, Vol. 22, p. 263-278, 2021/09/10
Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation, Junko Enomoto,Yukiko Toba,Haruka Yamazaki,Masaki Kanai,Hiroyuki Mizuguchi,Hayato Matsui, ACS APPLIED BIO MATERIALS, AMER CHEMICAL SOC, Vol. 4, No. 9, p. 7290-7299, 2021/09
Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies., Jumpei Yokota,Tomoki Yamashita,Tatsuya Inui,Ryuga Nomoto,Wataru Kishimoto,Hiroshi Nakase,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 566, p. 115-122, 2021/08/20
Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes., Sayaka Deguchi,Masahiro Tsuda,Kaori Kosugi,Ayaka Sakamoto,Natsumi Mimura,Ryosuke Negoro,Emi Sano,Takuro Nobe,Kazuya Maeda,Hiroyuki Kusuhara,Hiroyuki Mizuguchi,Fumiyoshi Yamashita,Yu-Suke Torisawa,Kazuo Takayama, ACS biomaterials science & engineering, Vol. 7, No. 8, p. 3648-3657, 2021/08/09
In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology., Sayaka Deguchi,Tomohiro Shintani,Kazuo Harada,Toru Okamoto,Akinori Takemura,Kazumasa Hirata,Kousei Ito,Kazuo Takayama,Hiroyuki Mizuguchi, Hepatology communications, Vol. 5, No. 8, p. 1385-1399, 2021/08
Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system., Moe Ichikawa,Hiroki Akamine,Michika Murata,Sumito Ito,Kazuo Takayama,Hiroyuki Mizuguchi, Scientific reports, Vol. 11, No. 1, p. 11670-11670, 2021/06/03
A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells., Takamasa Hirai,Ken Kono,Rumi Sawada,Takuya Kuroda,Satoshi Yasuda,Satoko Matsuyama,Akifumi Matsuyama,Naoya Koizumi,Naoki Utoguchi,Hiroyuki Mizuguchi,Yoji Sato, Scientific reports, Vol. 11, No. 1, p. 11407-11407, 2021/06/01
A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner., Ikuho Ishigami,Naomi Shuwari,Tadataka Kaminade,Hiroyuki Mizuguchi,Fuminori Sakurai, Anticancer research, Vol. 41, No. 5, p. 2431-2440, 2021/05
Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus., Chieko Inoue,Ryosuke Negoro,Kazuo Takayama,Hiroyuki Mizuguchi,Fuminori Sakurai, Virus research, Vol. 296, p. 198334-198334, 2021/04/15
The infectivity of progeny adenovirus in the presence of neutralizing antibody, Takamasa Hirai,Anna Sato,Naoya Koizumi,Yoh Kurioka,Yui Suzuki,Junpei Kano,Makie Yamakawa,Tetsuya Nomura,Makiko Fujii,Fuminori Sakurai,Hiroyuki Mizuguchi,Yoshiteru Watanabe,Naoki Utoguchi, Journal of General Virology, Microbiology Society, Vol. 102, No. 4, 2021/04/12
ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance, Kahori Shimizu,Yuya Ogiya,Kaede Yoshinaga,Hajime Kimura,Shotaro Michinaga,Moe Ono,Ayako Taketomi,Tomoyuki Terada,Fuminori Sakurai,Hiroyuki Mizuguchi,Koji Tomita,Toru Nishinaka, Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, 2021/03/29
Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35., Ryosuke Ono,Kosuke Takayama,Fuminori Sakurai,Hiroyuki Mizuguchi, Molecular therapy oncolytics, Vol. 20, p. 399-409, 2021/03/26
Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells, Moe Ichikawa,Ryosuke Negoro,Kanae Kawai,Tomoki Yamashita,Kazuo Takayama,Hiroyuki Mizuguchi, Molecular Therapy - Methods & Clinical Development, Elsevier BV, Vol. 20, p. 463-472, 2021/03
In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics, Kazuo Takayama,Kohei Ito,Akiko Matsui,Tomoki Yamashita,Kentaro Kawakami,Daisuke Hirayama,Wataru Kishimoto,Hiroshi Nakase,Hiroyuki Mizuguchi, Drug Metabolism and Disposition, American Society for Pharmacology & Experimental Therapeutics (ASPET), Vol. 49, No. 3, p. 221-232, 2021/03
Optimization of an E1A Gene Expression Cassette in an Oncolytic Adenovirus for Efficient Tumor Cell Killing Activity., Fuminori Sakurai,Fumitaka Nishimae,Kosuke Takayama,Hiroyuki Mizuguchi, Anticancer research, Vol. 41, No. 2, p. 773-782, 2021/02
Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity., Kahori Shimizu,Fuminori Sakurai,Shunsuke Iizuka,Ryosuke Ono,Tomohito Tsukamoto,Fumitaka Nishimae,Shin-Ichiro Nakamura,Toru Nishinaka,Tomoyuki Terada,Yasushi Fujio,Hiroyuki Mizuguchi, Journal of immunology (Baltimore, Md. : 1950), Vol. 206, No. 2, p. 410-421, 2021/01/15
Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3'-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver., Fuminori Sakurai,Tomohito Tsukamoto,Ryosuke Ono,Fumitaka Nishimae,Aoi Shiota,Shunsuke Iizuka,Kahori Shimizu,Eiko Sakai,Yuji Ishida,Chise Tateno,Kazuaki Chayama,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 44, No. 10, p. 1506-1513, 2021
Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine, Tomoki Yamashita,Kazuo Takayama,Hiroyuki Mizuguchi, Cell-Inspired Materials and Engineering, Springer International Publishing, p. 3-26, 2021
テロメラーゼ特異的腫瘍融解アデノウイルス製剤の併用による抗PD-1抗体治療効果の増強, 橋本将志,黒田新士,金谷信彦,八木千晶,津村朋子,公文剣斗,垣内慶彦,菊地覚次,田澤大,香川俊輔,水口裕之,浦田泰生,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 79回, p. OE12-10, 2020/10
Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan, Teruhide Yamaguchi,Eriko Uchida,Takashi Okada,Keiya Ozawa,Masafumi Onodera,Akihiro Kume,Takashi Shimada,Satoru Takahashi,Kenzaburo Tani,Yasutomo Nasu,Tomoji Mashimo,Hiroyuki Mizuguchi,Kohnosuke Mitani,Kazushige Maki, Human Gene Therapy, Mary Ann Liebert Inc, Vol. 31, No. 19-20, p. 1043-1053, 2020/10/01
Potential of human iPS cell-derived intestinal epithelial cells as a tool for pharmacokinetic assessment, Tomoki Yamashita,Jumpei Yokota,Tatsuya Inui,Hiroyuki Mizuguchi, Drug Delivery System, Japan Society of Drug Delivery System, Vol. 35, No. 4, p. 309-318, 2020/09/25
Sequence search for cloning and genome editing, Tetsuya Suzuki,Tomohito Tsukamoto,Eiko Sakai,Hiroyuki Mizuguchi,Hiroyuki Mizuguchi, Drug Delivery System, Japan Society of Drug Delivery System, Vol. 35, No. 3, p. 255-259, 2020/07/25
Photoactivatable oncolytic adenovirus for optogenetic cancer therapy, Yasuko Hagihara,Ayaka Sakamoto,Takashi Tokuda,Tomoki Yamashita,Sena Ikemoto,Ayaka Kimura,Makito Haruta,Kiyotaka Sasagawa,Jun Ohta,Kazuo Takayama,Hiroyuki Mizuguchi, Cell Death and Disease, Vol. 11, No. 7, 2020/07/01
Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer., Takeshi Koujima,Hiroshi Tazawa,Takeshi Ieda,Hiroyuki Araki,Takuro Fushimi,Ryohei Shoji,Shinji Kuroda,Satoru Kikuchi,Ryuichi Yoshida,Yuzo Umeda,Fuminori Teraishi,Yasuo Urata,Hiroyuki Mizuguchi,Toshiyoshi Fujiwara, Molecular therapy oncolytics, Vol. 17, p. 107-117, 2020/06/26
Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies., Kanae Kawai,Ryosuke Negoro,Moe Ichikawa,Tomoki Yamashita,Sayaka Deguchi,Kazuo Harada,Kazumasa Hirata,Kazuo Takayama,Hiroyuki Mizuguchi, Molecular therapy. Methods & clinical development, Vol. 17, p. 49-57, 2020/06/12
Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production., Masashi Tachibana,Nobumasa Watanabe,Yuzo Koda,Yukako Oya,Osamu Kaminuma,Kazufumi Katayama,Zifei Fan,Fuminori Sakurai,Kenji Kawabata,Takachika Hiroi,Hiroyuki Mizuguchi, International immunology, Vol. 32, No. 3, p. 187-201, 2020/03/07
Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody., Nobuhiko Kanaya,Shinji Kuroda,Yoshihiko Kakiuchi,Kento Kumon,Tomoko Tsumura,Masashi Hashimoto,Toshiaki Morihiro,Tetsushi Kubota,Katsuyuki Aoyama,Satoru Kikuchi,Masahiko Nishizaki,Shunsuke Kagawa,Hiroshi Tazawa,Hiroyuki Mizuguchi,Yasuo Urata,Toshiyoshi Fujiwara, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 28, No. 3, p. 794-804, 2020/03/04
Establishment of MDR1-knockout human induced pluripotent stem cell line., Ryosuke Negoro,Kanae Kawai,Moe Ichikawa,Sayaka Deguchi,Kazuo Takayama,Hiroyuki Mizuguchi, Drug metabolism and pharmacokinetics, Vol. 35, No. 3, p. 288-296, 2020/02/10
Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling., Ayumi Kiso,Yukiko Toba,Susumu Tsutsumi,Sayaka Deguchi,Keisuke Igai,Saki Koshino,Yasuhito Tanaka,Kazuo Takayama,Hiroyuki Mizuguchi, Hepatology communications, Vol. 4, No. 2, p. 255-267, 2020/02
Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A., Keisaku Wakabayashi,Fuminori Sakurai,Ryosuke Ono,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Anticancer research, Vol. 40, No. 1, p. 161-168, 2020/01
Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance., Yukiko Toba,Sayaka Deguchi,Natsumi Mimura,Ayaka Sakamoto,Kazuo Harada,Kazumasa Hirata,Kazuo Takayama,Hiroyuki Mizuguchi, PloS one, Vol. 15, No. 2, 2020
Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine., Sayaka Deguchi,Kazuo Takayama,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 43, No. 4, p. 608-615, 2020
Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells., Tomohito Tsukamoto,Eiko Sakai,Fumitaka Nishimae,Fuminori Sakurai,Hiroyuki Mizuguchi, Journal of biotechnology, Vol. 304, p. 1-9, 2019/10/10
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells., Sayaka Deguchi,Tomoki Yamashita,Keisuke Igai,Kazuo Harada,Yukiko Toba,Kazumasa Hirata,Kazuo Takayama,Hiroyuki Mizuguchi, Drug metabolism and disposition: the biological fate of chemicals, Vol. 47, No. 6, p. 632-638, 2019/06
miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers., Fuminori Sakurai,Rina Hashimoto,Chieko Inoue,Keisaku Wakabayashi,Tomohito Tsukamoto,Tsutomu Imaizumi,Taracena Gandara Marcos Andres,Eiko Sakai,Kanae Itsuki,Naoya Sakamoto,Takaji Wakita,Hiroyuki Mizuguchi, Virology journal, Vol. 16, No. 1, p. 58-58, 2019/05/02
Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors., Takuma Hotani,Hiroyuki Mizuguchi,Fuminori Sakurai, Molecular therapy oncolytics, Vol. 12, p. 162-172, 2019/03/29
Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells., Ken Kono,Rumi Sawada,Takuya Kuroda,Satoshi Yasuda,Satoko Matsuyama,Akifumi Matsuyama,Hiroyuki Mizuguchi,Yoji Sato, Scientific reports, Vol. 9, No. 1, p. 3630-3630, 2019/03/06
FGF signal is not required for hepatoblast differentiation of human iPS cells., Yukiko Toba,Ayumi Kiso,Souichiro Nakamae,Fuminori Sakurai,Kazuo Takayama,Hiroyuki Mizuguchi, Scientific reports, Vol. 9, No. 1, p. 3713-3713, 2019/03/06
A MicroRNA Derived from Adenovirus Virus-Associated RNAII Promotes Virus Infection via Posttranscriptional Gene Silencing., K Wakabayashi,M Machitani,M Tachibana,F Sakurai,H Mizuguchi, Journal of virology, Vol. 93, No. 2, 2019/01/15
Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies., Tomoki Yamashita,Kazuo Takayama,Mika Hori,Mariko Harada-Shiba,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 42, No. 3, p. 312-318, 2019
Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction., Kazuo Takayama,Ryosuke Negoro,Tomoki Yamashita,Kanae Kawai,Moe Ichikawa,Takanori Mori,Noriyuki Nakatsu,Kazuo Harada,Sumito Ito,Hiroshi Yamada,Yoshiyuki Yamaura,Kazumasa Hirata,Seiichi Ishida,Hiroyuki Mizuguchi, Cellular and molecular gastroenterology and hepatology, Vol. 8, No. 3, p. 513-526, 2019
Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies., Ryosuke Negoro,Kazuo Takayama,Kanae Kawai,Kazuo Harada,Fuminori Sakurai,Kazumasa Hirata,Hiroyuki Mizuguchi, Stem cell reports, Vol. 11, No. 6, p. 1539-1550, 2018/12/11
Optimal human iPS cell culture method for efficient hepatic differentiation, Nobumasa Matoba,Tomoki Yamashita,Kazuo Takayama,Fuminori Sakurai,Hiroyuki Mizuguchi, Differentiation, Elsevier BV, Vol. 104, p. 13-21, 2018/11
Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration., Kyoko Tomita,Fuminori Sakurai,Shunsuke Iizuka,Masahisa Hemmi,Keisaku Wakabayashi,Mitsuhiro Machitani,Masashi Tachibana,Kazufumi Katayama,Haruhiko Kamada,Hiroyuki Mizuguchi, Scientific reports, Vol. 8, No. 1, p. 12315-12315, 2018/08/17
Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review., Junko Watanabe,Shinsaku Togo,Issei Sumiyoshi,Yukiko Namba,Kentaro Suina,Takafumi Mizuno,Kotaro Kadoya,Hiroaki Motomura,Moe Iwai,Tetsutaro Nagaoka,Shinichi Sasaki,Takuo Hayashi,Toshimasa Uekusa,Kanae Abe,Yasuo Urata,Fuminori Sakurai,Hiroyuki Mizuguchi,Shunsuke Kato,Kazuhisa Takahashi, Oncotarget, Vol. 9, No. 35, p. 24000-24013, 2018/05/08
Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner., Yuki Katayama,Masashi Tachibana,Nozomi Kurisu,Yukako Oya,Yuichi Terasawa,Hiroshi Goda,Kouji Kobiyama,Ken J Ishii,Shizuo Akira,Hiroyuki Mizuguchi,Fuminori Sakurai, Journal of immunology (Baltimore, Md. : 1950), Vol. 200, No. 8, p. 2987-2999, 2018/04/15
ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation., Toru Tanaka,Kohei Izawa,Yusuke Maniwa,Maki Okamura,Atsumasa Okada,Tomoko Yamaguchi,Keisuke Shirakura,Naoki Maekawa,Hayato Matsui,Kenji Ishimoto,Nobumasa Hino,Osamu Nakagawa,William C Aird,Hiroyuki Mizuguchi,Kenji Kawabata,Takefumi Doi,Yoshiaki Okada, Scientific reports, Vol. 8, No. 1, p. 5653-5653, 2018/04/04
Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research., Kazuo Takayama,Yasuko Hagihara,Yukiko Toba,Kiyotoshi Sekiguchi,Fuminori Sakurai,Hiroyuki Mizuguchi, Biomaterials, Vol. 161, p. 24-32, 2018/04
Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells., Souichiro Nakamae,Yukiko Toba,Kazuo Takayama,Fuminori Sakurai,Hiroyuki Mizuguchi, Stem cells and development, Vol. 27, No. 6, p. 405-414, 2018/03/15
Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells., Tomoki Yamashita,Kazuo Takayama,Fuminori Sakurai,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 496, No. 4, p. 1269-1275, 2018/02/19
Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy., Kazuo Takayama,Hiroyuki Mizuguchi, ACS chemical biology, Vol. 13, No. 2, p. 449-454, 2018/02/16
Occludin as a functional marker of vascular endothelial cells on tube-forming activity., Toshie Kanayasu-Toyoda,Akiko Ishii-Watabe,Yutaka Kikuchi,Hiroko Kitagawa,Hiroko Suzuki,Hiroomi Tamura,Minoru Tada,Takuo Suzuki,Hiroyuki Mizuguchi,Teruhide Yamaguchi, Journal of cellular physiology, Vol. 233, No. 2, p. 1700-1711, 2018/02
Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B., Ryota Okamoto,Kazuo Takayama,Naoki Akita,Yasuhito Nagamoto,Daiki Hosokawa,Shunsuke Iizuka,Fuminori Sakurai,Hiroshi Suemizu,Kazuo Ohashi,Hiroyuki Mizuguchi, Cell transplantation, Vol. 27, No. 2, p. 299-309, 2018/02
Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells., Masahiro Takakura,Takeo Matsumoto,Mitsuhiro Nakamura,Yasunari Mizumoto,Subaru Myojyo,Rena Yamazaki,Jyunpei Iwadare,Yukiko Bono,Shunsuke Orisaka,Takeshi Obata,Takashi Iizuka,Kyosuke Kagami,Kentaro Nakayama,Hideki Hayakawa,Fuminori Sakurai,Hiroyuki Mizuguchi,Yasuo Urata,Toshiyoshi Fujiwara,Satoru Kyo,Toshiyuki Sasagawa,Hiroshi Fujiwara, Cancer science, Vol. 109, No. 1, p. 231-240, 2018/01
Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver., Tomohito Tsukamoto,Eiko Sakai,Shunsuke Iizuka,Marcos Taracena-Gándara,Fuminori Sakurai,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 41, No. 7, p. 1089-1095, 2018
A Flow Cytometry-Based Method to Determine the Titer of Adenoviruses Expressing an Extraneous Gene., Akikazu Asada,Hideki Hayakawa,Natsuki Yanase,Kanae Abe,Fuminori Sakurai,Hiroyuki Mizuguchi,Yasuo Urata, Biological & pharmaceutical bulletin, Vol. 41, No. 10, p. 1615-1619, 2018
LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth., Naosuke Morikawa,Masashi Tachibana,Yukio Ago,Hiroshi Goda,Fuminori Sakurai,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 41, No. 12, p. 1866-1869, 2018
Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Kosuke Nakatani,Masashi Tachibana,Nobuyuki Kato,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Molecular therapy oncolytics, Vol. 7, p. 76-85, 2017/12/15
Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine., Kazuo Takayama,Naoki Akita,Natsumi Mimura,Rina Akahira,Yukimasa Taniguchi,Makoto Ikeda,Fuminori Sakurai,Osamu Ohara,Tomohiro Morio,Kiyotoshi Sekiguchi,Hiroyuki Mizuguchi, Hepatology communications, Vol. 1, No. 10, p. 1058-1069, 2017/12
Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction., Daiki Nakamori,Hiroki Akamine,Kazuo Takayama,Fuminori Sakurai,Hiroyuki Mizuguchi, Scientific reports, Vol. 7, No. 1, p. 16675-16675, 2017/11/30
Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells., Fuminori Sakurai,Takemaru Kunito,Kazuo Takayama,Rina Hashimoto,Masashi Tachibana,Naoya Sakamoto,Takaji Wakita,Hiroyuki Mizuguchi, Virus research, Vol. 242, p. 7-15, 2017/10/15
Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes., Shunsuke Iizuka,Fuminori Sakurai,Masashi Tachibana,Kazuo Ohashi,Hiroyuki Mizuguchi, Molecular therapy. Methods & clinical development, Vol. 6, p. 183-193, 2017/09/15
新規光線力学療法としての蛍光タンパク質KillerRed誘導腫瘍融解ウイルスのin vivo抗腫瘍効果, 竹原清人,田澤大,矢野修也,岸本浩行,水口裕之,浦田泰生,ホフマン・ロバート,香川俊輔,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 76回, p. P-3386, 2017/09
Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus., Kiyoto Takehara,Shuya Yano,Hiroshi Tazawa,Hiroyuki Kishimoto,Nobuhiro Narii,Hiroyuki Mizuguchi,Yasuo Urata,Shunsuke Kagawa,Toshiyoshi Fujiwara,Robert M Hoffman, Cell cycle (Georgetown, Tex.), Vol. 16, No. 16, p. 1502-1508, 2017/08/18
Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells., Morifumi Hanawa,Kazuo Takayama,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Stem cell reviews and reports, Vol. 13, No. 4, p. 542-551, 2017/08
A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2., Eiko Sakai,Yusuke Miura,Emi Suzuki-Kouyama,Kengo Oka,Masashi Tachibana,Kenji Kawabata,Fuminori Sakurai,Hiroyuki Mizuguchi, Scientific reports, Vol. 7, No. 1, p. 5541-5541, 2017/07/17
Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis., Kahori Shimizu,Minako Okamoto,Tomoyuki Terada,Fuminori Sakurai,Hiroyuki Mizuguchi,Koji Tomita,Toru Nishinaka, Biochemistry and biophysics reports, Vol. 10, p. 192-197, 2017/07
MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Kosuke Nakatani,Masashi Tachibana,Hiroyuki Mizuguchi, Journal of virology, Vol. 91, No. 12, 2017/06/15
Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling., Seiji Mitani,Kazuo Takayama,Yasuhito Nagamoto,Kazuo Imagawa,Fuminori Sakurai,Masashi Tachibana,Ryo Sumazaki,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, No. 6, p. 1420-1433, 2017/06/07
Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells., Fuminori Sakurai,Shunsuke Inoue,Tadataka Kaminade,Takuma Hotani,Yuki Katayama,Eri Hosoyamada,Yuichi Terasawa,Masashi Tachibana,Hiroyuki Mizuguchi, International journal of pharmaceutics, Vol. 524, No. 1-2, p. 238-247, 2017/05/30
Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients., Shinsaku Togo,Nobuyoshi Katagiri,Yukiko Namba,Miniwan Tulafu,Kumi Nagahama,Kotarou Kadoya,Kazuya Takamochi,Siaki Oh,Kenji Suzuki,Fuminori Sakurai,Hiroyuki Mizuguchi,Yasuo Urata,Kazuhisa Takahashi, Oncotarget, Vol. 8, No. 21, p. 34884-34895, 2017/05/23
Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system., Kazuo Takayama,Keisuke Igai,Yasuko Hagihara,Rina Hashimoto,Morifumi Hanawa,Tetsushi Sakuma,Masashi Tachibana,Fuminori Sakurai,Takashi Yamamoto,Hiroyuki Mizuguchi, Nucleic acids research, Vol. 45, No. 9, p. 5198-5207, 2017/05/19
Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection., Fuminori Sakurai,Seiji Mitani,Tatsuro Yamamoto,Kazuo Takayama,Masashi Tachibana,Koichi Watashi,Takaji Wakita,Sayuki Iijima,Yasuhito Tanaka,Hiroyuki Mizuguchi, Scientific reports, Vol. 7, p. 45698-45698, 2017/04/04
Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Kosuke Takayama,Masashi Tachibana,Hiroyuki Mizuguchi, Molecular therapy. Nucleic acids, Vol. 6, p. 173-182, 2017/03/17
Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions., Takayuki Fukuda,Kazuo Takayama,Mitsuhi Hirata,Yu-Jung Liu,Kana Yanagihara,Mika Suga,Hiroyuki Mizuguchi,Miho K Furue, Experimental cell research, Vol. 352, No. 2, p. 333-345, 2017/03/15
Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells., Kazuo Imagawa,Kazuo Takayama,Shigemi Isoyama,Ken Tanikawa,Masato Shinkai,Kazuo Harada,Masashi Tachibana,Fuminori Sakurai,Emiko Noguchi,Kazumasa Hirata,Masayoshi Kage,Kenji Kawabata,Ryo Sumazaki,Hiroyuki Mizuguchi, Scientific reports, Vol. 7, p. 41806-41806, 2017/02/02
Identification of Adenovirus-Derived Cell-Penetrating Peptide, Takamasa Hirai,Yoshiaki Yamagishi,Naoya Koizumi,Miwa Nonaka,Rina Mochida,Kenta Shida,Tetsuya Nomura,Makiko Fujii,Fuminori Sakurai,Hiroyuki Mizuguchi,Yoshiteru Watanabe,Naoki Utoguchi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 40, No. 2, p. 195-204, 2017/02
Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening., Kazuo Takayama,Hiroyuki Mizuguchi, Drug metabolism and pharmacokinetics, Vol. 32, No. 1, p. 12-20, 2017/02
Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Masashi Tachibana,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Molecular cancer therapeutics, Vol. 16, No. 1, p. 251-259, 2017/01
Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Kosuke Nakatani,Kazuo Takayama,Masashi Tachibana,Hiroyuki Mizuguchi, Biological & pharmaceutical bulletin, Vol. 40, No. 3, p. 272-277, 2017
T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination., Masahisa Hemmi,Masashi Tachibana,Natsuki Fujimoto,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Ken J Ishii,Shizuo Akira,Hiroyuki Mizuguchi, Frontiers in immunology, Vol. 8, p. 1456-1456, 2017
Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells., Kana Yanagihara,Yujung Liu,Kei Kanie,Kazuo Takayama,Minako Kokunugi,Mitsuhi Hirata,Takayuki Fukuda,Mika Suga,Hiroki Nikawa,Hiroyuki Mizuguchi,Ryuji Kato,Miho K Furue, Stem cells and development, Vol. 25, No. 24, p. 1884-1897, 2016/12/15
Expression of HIF-1α ODD domain fused canine caspase 3 by EGFR promoter-driven adenovirus vector induces cytotoxicity in canine breast tumor cells under hypoxia., Mariko Okamoto,Ai Asamura,Ko Tanaka,Takefumi Soeda,Kyo Watanabe,Hiroyuki Mizuguchi,Teruo Ikeda, Veterinary research communications, Vol. 40, No. 3-4, p. 131-139, 2016/12
Tumor-specific delivery of biologics by a novel T-cell line HOZOT., Teppei Onishi,Hiroshi Tazawa,Yuuri Hashimoto,Makoto Takeuchi,Takeshi Otani,Shuji Nakamura,Fuminori Sakurai,Hiroyuki Mizuguchi,Hiroyuki Kishimoto,Yuzo Umeda,Yasuhiro Shirakawa,Yasuo Urata,Shunsuke Kagawa,Toshiyoshi Fujiwara, Scientific reports, Vol. 6, p. 38060-38060, 2016/11/30
Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines., Ayami Kita,Nobumasa Hino,Sakiko Higashi,Kohji Hirota,Ryohei Narumi,Jun Adachi,Kazuaki Takafuji,Kenji Ishimoto,Yoshiaki Okada,Kensaku Sakamoto,Takeshi Tomonaga,Seiji Takashima,Hiroyuki Mizuguchi,Takefumi Doi, Scientific reports, Vol. 6, p. 36946-36946, 2016/11/11
Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA., Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Kyoko Tomita,Masashi Tachibana,Hiroyuki Mizuguchi, Scientific reports, Vol. 6, p. 27598-27598, 2016/06/07
NASH/NAFLDにおける肝microRNa-27bの臓器移行を介した肥満形成メカニズム, 結束貴臣,本多靖,小川祐二,留野渉,今城健人,馬渡弘典,藤田浩司,米田正人,斉藤聡,中島淳,酒井英子,水口裕之,和田孝一郎, アルコールと医学生物学, (株)響文社, Vol. 34, p. 94-95, 2016/06
Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells., Kazuo Takayama,Seiji Mitani,Yasuhito Nagamoto,Fuminori Sakurai,Masashi Tachibana,Yukimasa Taniguchi,Kiyotoshi Sekiguchi,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 474, No. 1, p. 91-96, 2016/05/20
Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure., Yasuhito Nagamoto,Kazuo Takayama,Kazuo Ohashi,Ryota Okamoto,Fuminori Sakurai,Masashi Tachibana,Kenji Kawabata,Hiroyuki Mizuguchi, Journal of hepatology, Vol. 64, No. 5, p. 1068-1075, 2016/05
Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells., Ryosuke Negoro,Kazuo Takayama,Yasuhito Nagamoto,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 472, No. 4, p. 631-6, 2016/04/15
Adenoviral Vector Construction II: Bacterial Systems, Masahisa Hemmi,Hiroyuki Mizuguchi, Adenoviral Vectors for Gene Therapy: Second Edition, Elsevier Inc., p. 113-137, 2016/04/06
TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector., Sayaka Tsuzuki,Masashi Tachibana,Masahisa Hemmi,Tomoko Yamaguchi,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Kenji Kawabata,Ken J Ishii,Shizuo Akira,Hiroyuki Mizuguchi, International immunology, Vol. 28, No. 3, p. 105-15, 2016/03
Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction., Daiki Nakamori,Kazuo Takayama,Yasuhito Nagamoto,Seiji Mitani,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 469, No. 3, p. 424-9, 2016/01/15
Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells, Li Wan,Xinglei Yao,Francesco Faiola,Bojun Liu,Tianyuan Zhang,Yasuhiko Tabata,Hiroyuki Mizuguchi,Shinsaku Nakagawa,Jian-Qing Gao,Robert Chunhua Zhao, INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD, Vol. 11, p. 6763-6769, 2016
NF-kappa B promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector, M. Machitani,F. Sakurai,K. Wakabayashi,K. Nakatani,K. Shimizu,M. Tachibana,H. Mizuguchi, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 6, 2016/01
Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer., Kiyoto Takehara,Hiroshi Tazawa,Naohiro Okada,Yuuri Hashimoto,Satoru Kikuchi,Shinji Kuroda,Hiroyuki Kishimoto,Yasuhiro Shirakawa,Nobuhiro Narii,Hiroyuki Mizuguchi,Yasuo Urata,Shunsuke Kagawa,Toshiyoshi Fujiwara, Molecular cancer therapeutics, Vol. 15, No. 1, p. 199-208, 2016/01
Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus., Fuminori Sakurai,Nobuhiro Narii,Kyoko Tomita,Shinsaku Togo,Kazuhisa Takahashi,Mitsuhiro Machitani,Masashi Tachibana,Masaaki Ouchi,Nobuyoshi Katagiri,Yasuo Urata,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Molecular therapy. Methods & clinical development, Vol. 3, p. 16001-16001, 2016
Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors., Hiroyuki Hanayama,Kazuo Ohashi,Rie Utoh,Hirofumi Shimizu,Kazuya Ise,Fuminori Sakurai,Hiroyuki Mizuguchi,Hiroyuki Tsuchiya,Teruo Okano,Mitsukazu Gotoh, Cell medicine, Vol. 8, No. 1-2, p. 31-8, 2015/12/17
NASH/NAFLD関連マイクロRNA miR-27bの脂質蓄積促進能を担う標的遺伝子の解析, 鈴木瑠々香,酒井英子,立花雅史,櫻井文教,結束貴臣,中島淳,和田孝一郎,水口裕之, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, Vol. 88回・38回, p. [1P1207]-[1P1207], 2015/12
Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine., Tatsuya Ozawa,Kazuo Takayama,Ryota Okamoto,Ryosuke Negoro,Fuminori Sakurai,Masashi Tachibana,Kenji Kawabata,Hiroyuki Mizuguchi, Scientific reports, Vol. 5, p. 16479-16479, 2015/11/12
Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α., Takuma Hotani,Masashi Tachibana,Hiroyuki Mizuguchi,Fuminori Sakurai, Biochemical and biophysical research communications, Vol. 460, No. 4, p. 1041-6, 2015/05/15
Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in fetal liver kinase 1-expressing mesoderm., Katsuhisa Tashiro,Nobue Hirata,Atsumasa Okada,Tomoko Yamaguchi,Kazuo Takayama,Hiroyuki Mizuguchi,Kenji Kawabata, Stem cells translational medicine, Vol. 4, No. 5, p. 424-36, 2015/05
Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo., Wakabayashi K,Machitani M,Shimizu K,Tachibana M,Sakurai F,Mizuguchi H, J. Mol. Genet. Med., Vol. 9, No. 2, 2015/04
NAFLD/NASH関連マイクロRNA miR-27bの肝脂肪化促進能を担う新規標的遺伝子の探索, 今泉務,酒井英子,立花雅史,櫻井文教,結束貴臣,中島淳,和田孝一郎,水口裕之, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 135年会, No. 3, p. 68-68, 2015/03
Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing., Terasawa Y,Hotani T,Katayama Y,Tachibana M,Mizuguchi H,Sakurai F, Cancer gene therapy, Vol. 22, No. 4, p. 188-197, 2015/03
Efficient Adenovirus Gene Transfer Methods in Human Colonic Caco-2 Epithelial Cells Using Capric Acid., Naoya Koizumi,Yoshiaki Yamagishi,Takamasa Hirai,Makiko Fujii,Hiroyuki Mizuguchi,Yoshiteru Watanabe, Biological & pharmaceutical bulletin, Vol. 38, No. 8, p. 1240-4, 2015
Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene., Yasuhito Nagamoto,Kazuo Takayama,Katsuhisa Tashiro,Chise Tateno,Fuminori Sakurai,Masashi Tachibana,Kenji Kawabata,Kazuo Ikeda,Yasuhito Tanaka,Hiroyuki Mizuguchi, Cell transplantation, Vol. 24, No. 6, p. 1127-38, 2015
Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and reovirus-refractory tumor cells., Yuki Katayama,Yuichi Terasawa,Masashi Tachibana,Hiroyuki Mizuguchi,Fuminori Sakurai, BioMed research international, Vol. 2015, p. 468457-468457, 2015
Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells., Haruka Minami,Katsuhisa Tashiro,Atsumasa Okada,Nobue Hirata,Tomoko Yamaguchi,Kazuo Takayama,Hiroyuki Mizuguchi,Kenji Kawabata, PloS one, Vol. 10, No. 6, 2015
Evaluation of transduction properties of an adenovirus vector in neonatal mice., Shunsuke Iizuka,Fuminori Sakurai,Kahori Shimizu,Kazuo Ohashi,Shin-Ichiro Nakamura,Masashi Tachibana,Hiroyuki Mizuguchi, BioMed research international, Vol. 2015, p. 685374-685374, 2015
Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD., Junko Mori,Akiko Kawabata,Huamin Tang,Kenjiro Tadagaki,Hiroyuki Mizuguchi,Kazumichi Kuroda,Yasuko Mori, PloS one, Vol. 10, No. 9, 2015
Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes., Kazuo Takayama,Yuta Morisaki,Shuichi Kuno,Yasuhito Nagamoto,Kazuo Harada,Norihisa Furukawa,Manami Ohtaka,Ken Nishimura,Kazuo Imagawa,Fuminori Sakurai,Masashi Tachibana,Ryo Sumazaki,Emiko Noguchi,Mahito Nakanishi,Kazumasa Hirata,Kenji Kawabata,Hiroyuki Mizuguchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 47, p. 16772-7, 2014/11/25
Plasma Elevation of Vascular Endothelial Growth Factor Leads to the Reduction of Mouse Hematopoietic and Mesenchymal Stem/Progenitor Cells in the Bone Marrow, Katsuhisa Tashiro,Aki Nonaka,Nobue Hirata,Tomoko Yamaguchi,Hiroyuki Mizuguchi,Kenji Kawabata, STEM CELLS AND DEVELOPMENT, MARY ANN LIEBERT, INC, Vol. 23, No. 18, p. 2202-2210, 2014/09
Protective mucosal immunity mediated by epithelial CD1d and IL-10., Torsten Olszak,Joana F Neves,C Marie Dowds,Kristi Baker,Jonathan Glickman,Nicholas O Davidson,Chyuan-Sheng Lin,Christian Jobin,Stephan Brand,Karl Sotlar,Koichiro Wada,Kazufumi Katayama,Atsushi Nakajima,Hiroyuki Mizuguchi,Kunito Kawasaki,Kazuhiro Nagata,Werner Müller,Scott B Snapper,Stefan Schreiber,Arthur Kaser,Sebastian Zeissig,Richard S Blumberg, Nature, Vol. 509, No. 7501, p. 497-502, 2014/05/22
Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells., Xinglei Yao,Na Zhou,Li Wan,Xiaodong Su,Zhao Sun,Hiroyuki Mizuguchi,Yasuo Yoshioka,Shinsaku Nakagawa,Robert Chunhua Zhao,Jian-Qing Gao, Biochemical and biophysical research communications, Vol. 447, No. 3, p. 383-7, 2014/05/09
Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region, F. Sakurai,Y. Nanjo,S. Okamoto,M. Tachibanal,H. Mizuguchi, CANCER GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 21, No. 4, p. 164-170, 2014/04
Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth, M. Tagawa,K. Shirane,L. Yu,T. Sato,S. Furukawa,H. Mizuguchi,R. Kuji,K. Kawamura,N. Takahashi,K. Kato,S. Hayakawa,S. Sawada,K. Furukawa, Cancer Gene Therapy, Nature Publishing Group, Vol. 21, No. 6, p. 219-227, 2014
CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision., Kazuo Takayama,Kenji Kawabata,Yasuhito Nagamoto,Mitsuru Inamura,Kazuo Ohashi,Hiroko Okuno,Tomoko Yamaguchi,Katsuhisa Tashiro,Fuminori Sakurai,Takao Hayakawa,Teruo Okano,Miho Kusada Furue,Hiroyuki Mizuguchi, Development (Cambridge, England), Vol. 141, No. 1, p. 91-100, 2014/01
Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome., Kahori Shimizu,Fuminori Sakurai,Kyoko Tomita,Yasuhito Nagamoto,Shin-Ichiro Nakamura,Kazufumi Katayama,Masashi Tachibana,Kenji Kawabata,Hiroyuki Mizuguchi, Molecular therapy. Methods & clinical development, Vol. 1, p. 14035-14035, 2014
Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4., Shuichi Kuno,Fuminori Sakurai,Kahori Shimizu,Naoya Matsumura,Soonih Kim,Hitoshi Watanabe,Katsuhisa Tashiro,Masashi Tachibana,Tsuyoshi Yokoi,Hiroyuki Mizuguchi, Drug metabolism and pharmacokinetics, Vol. 29, No. 4, p. 296-304, 2014
HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin., Hitoshi Watanabe,Kazuo Takayama,Mitsuru Inamura,Masashi Tachibana,Natsumi Mimura,Kazufumi Katayama,Katsuhisa Tashiro,Yasuhito Nagamoto,Fuminori Sakurai,Kenji Kawabata,Miho Kusuda Furue,Hiroyuki Mizuguchi, PloS one, Vol. 9, No. 3, 2014
The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector., Masahisa Hemmi,Masashi Tachibana,Sayaka Tsuzuki,Masaki Shoji,Fuminori Sakurai,Kenji Kawabata,Kouji Kobiyama,Ken J Ishii,Shizuo Akira,Hiroyuki Mizuguchi, BioMed research international, Vol. 2014, p. 158128-158128, 2014
Improving adenovirus vector-mediated RNAi efficiency by lacking the expression of virus-associated RNAs, M. Machitani,F. Sakurai,K. Katayama,M. Tachibana,T. Suzuki,H. Matsui,T. Yamaguchi,H. Mizuguchi, VIRUS RESEARCH, ELSEVIER SCIENCE BV, Vol. 178, No. 2, p. 357-363, 2013/12
Ca(2+) spiking activity caused by the activation of store-operated Ca(2+) channels mediates TNF-α release from microglial cells under chronic purinergic stimulation., Masayuki Ikeda,Saki Tsuno,Takashi Sugiyama,Ayami Hashimoto,Kurumi Yamoto,Kouhei Takeuchi,Hiroyuki Kishi,Hiroyuki Mizuguchi,Shin-Ichi Kohsaka,Tohru Yoshioka, Biochimica et biophysica acta, Vol. 1833, No. 12, p. 2573-2585, 2013/12
新規光線力学療法を目指したウイルスを用いた光感受性細胞傷害性蛍光タンパク質KillerRedの治療効果(Virus-mediated delivery system of photosensitive cytotoxic fluorescent protein KillerRed for novel photodynamic therapy), 竹原清人,田澤大,橋本悠里,岸本浩行,水口裕之,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 72回, p. 503-503, 2013/10
Novel polyvalent live vaccine against varicella-zoster and mumps virus infections., Masaaki Matsuura,Pranee Somboonthum,Kouki Murakami,Megumi Ota,Masaki Shoji,Kenji Kawabata,Hiroyuki Mizuguchi,Yasuyuki Gomi,Koichi Yamanishi,Yasuko Mori, Microbiology and immunology, Vol. 57, No. 10, p. 704-14, 2013/10
Adenoviral Vector-Mediated Anti-Apoptotic Gene Transduction for Engineering Functional Islet Cell Sheets, Hanayama Hiroyuki,Ohashi Kazuo,Utoh Rie,Ise Kazuya,Shimizu Tatsuya,Yamato Masayuki,Mizuguchi Hiroyuki,Sakurai Fuminori,Okano Teruo,Gotoh Mitsukazu, TRANSPLANTATION, Vol. 96, No. 6, 2013/09/27
A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein., Hayato Matsui,Fuminori Sakurai,Kazufumi Katayama,Yasuhiro Abe,Mitsuhiro Machitani,Shinnosuke Kurachi,Masashi Tachibana,Hiroyuki Mizuguchi, Biomaterials, Vol. 34, No. 16, p. 4191-4201, 2013/05
Regulation of IgE-dependent zinc release from human mast cells, Kazuko Nakashima-Kaneda,Akira Matsuda,Hiroyuki Mizuguchi,Tomomi Sasaki-Sakamoto,Hirohisa Saito,Chisei Ra,Yoshimichi Okayama, International Archives of Allergy and Immunology, S. Karger AG, Vol. 161, p. 44-51, 2013/04/12
Two-step differentiation of mast cells from induced pluripotent stem cells, Tomoko Yamaguchi,Katsuhisa Tashiro,Satoshi Tanaka,Sumie Katayama,Waka Ishida,Ken Fukuda,Atsuki Fukushima,Ryoko Araki,Masumi Abe,Hiroyuki Mizuguchi,Kenji Kawabata, Stem Cells and Development, Vol. 22, No. 5, p. 726-734, 2013/03/01
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing., Kazuo Takayama,Kenji Kawabata,Yasuhito Nagamoto,Keisuke Kishimoto,Katsuhisa Tashiro,Fuminori Sakurai,Masashi Tachibana,Katsuhiro Kanda,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, Biomaterials, Vol. 34, No. 7, p. 1781-9, 2013/02
SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma, Kota Iwahori,Satoshi Serada,Minoru Fujimoto,Barry Ripley,Shintaro Nomura,Hiroyuki Mizuguchi,Kazuki Shimada,Tsuyoshi Takahashi,Ichiro Kawase,Tadamitsu Kishimoto,Tetsuji Naka, International Journal of Cancer, Vol. 132, No. 2, p. 459-471, 2013/01/15
Gamma-delta T cells may function as carrier vehicles in adenovirus vector-based gene therapy, Michio Naoe,Yoshio Ogawa,Yuki Hasebe,Kozo Fuji,Sanju Iwamoto,Hiroyuki Mizuguchi,Takashi Aoi,Shuji Terao, Journal of Cancer Science and Therapy, Vol. 5, No. 11, p. 384-390, 2013
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells, Hideko Akagi,Hajime Higuchi,Hidetoshi Sumimoto,Toru Igarashi,Ayano Kabashima,Hiroyuki Mizuguchi,Motoko Izumiya,Gen Sakai,Masayuki Adachi,Shinsuke Funakoshi,Shoko Nakamura,Yasuo Hamamoto,Takanori Kanai,Hiromasa Takaishi,Yutaka Kawakami,Toshifumi Hibi, Gastric Cancer, Vol. 16, No. 1, p. 100-110, 2013/01
NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites., Ryosuke Uchibori,Tomonori Tsukahara,Hiroyuki Mizuguchi,Yasushi Saga,Masashi Urabe,Hiroaki Mizukami,Akihiro Kume,Keiya Ozawa, Cancer research, Vol. 73, No. 1, p. 364-72, 2013/01/01
[Development of a detection system for circulating tumor cells in peripheral blood using a next generation conditionally-replicating adenovirus]., Fuminori Sakurai,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 133, No. 3, p. 291-6, 2013
[Development of an adenovirus vector containing a hepatitis C virus expression cassette and its application]., Takeshi Yoshida,Masuo Kondoh,Hiroyuki Mizuguchi,Kiyohito Yagi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 133, No. 3, p. 305-11, 2013
Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes., Kazuo Takayama,Yasuhito Nagamoto,Natsumi Mimura,Katsuhisa Tashiro,Fuminori Sakurai,Masashi Tachibana,Takao Hayakawa,Kenji Kawabata,Hiroyuki Mizuguchi, Stem cell reports, Vol. 1, No. 4, p. 322-35, 2013
Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microrna-mediated regulation and the Cre-loxP recombination system., David Bennett,Fuminori Sakurai,Kahori Shimizu,Hayato Matsui,Kyoko Tomita,Takayuki Suzuki,Kazufumi Katayama,Kenji Kawabata,Hiroyuki Mizuguchi, Molecular pharmaceutics, Vol. 9, No. 12, p. 3452-63, 2012/12/03
Inhibition of Lnk in Mouse Induced Pluripotent Stem Cells Promotes Hematopoietic Cell Generation, Katsuhisa Tashiro,Miyuki Omori,Kenji Kawabata,Nobue Hirata,Tomoko Yamaguchi,Fuminori Sakurai,Satoshi Takaki,Hiroyuki Mizuguchi, STEM CELLS AND DEVELOPMENT, MARY ANN LIEBERT INC, Vol. 21, No. 18, p. 3381-3390, 2012/12
Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments., Masaki Shoji,Kazufumi Katayama,Masashi Tachibana,Kyoko Tomita,Fuminori Sakurai,Kenji Kawabata,Hiroyuki Mizuguchi, Vaccine, Vol. 30, No. 50, p. 7278-85, 2012/11/26
A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression, Yasumoto Yamasaki,Hiroshi Tazawa,Yuuri Hashimoto,Toru Kojima,Shinji Kuroda,Shuya Yano,Ryosuke Yoshida,Futoshi Uno,Hiroyuki Mizuguchi,Akira Ohtsuru,Yasuo Urata,Shunsuke Kagawa,Toshiyoshi Fujiwara, EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Vol. 48, No. 14, p. 2282-2291, 2012/09
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction., Kazuo Takayama,Mitsuru Inamura,Kenji Kawabata,Michiko Sugawara,Kiyomi Kikuchi,Maiko Higuchi,Yasuhito Nagamoto,Hitoshi Watanabe,Katsuhisa Tashiro,Fuminori Sakurai,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, Journal of hepatology, Vol. 57, No. 3, p. 628-36, 2012/09
Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa., Masaki Shoji,Masashi Tachibana,Kazufumi Katayama,Kyoko Tomita,Sayaka Tsuzuki,Fuminori Sakurai,Kenji Kawabata,Ken J Ishii,Shizuo Akira,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 425, No. 1, p. 89-93, 2012/08/17
Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy., Xing-Lei Yao,Yasuo Yoshioka,Gui-Xin Ruan,Yu-Zhe Chen,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Jian-Qing Gao,Shinsaku Nakagawa, Biomacromolecules, Vol. 13, No. 8, p. 2402-9, 2012/08/13
Improved gene transfer into bladder cancer cells using adenovirus vector containing RGD motif, Kazuhiro Hiwasa,Hisao Nagaya,Shuji Terao,Bishnu Acharya,Katsuyuki Hamada,Hiroyuki Mizuguchi,Akinobu Gotoh, Anticancer Research, Vol. 32, No. 8, p. 3137-3140, 2012/08
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets., Yasuhito Nagamoto,Katsuhisa Tashiro,Kazuo Takayama,Kazuo Ohashi,Kenji Kawabata,Fuminori Sakurai,Masashi Tachibana,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, Biomaterials, Vol. 33, No. 18, p. 4526-34, 2012/06
Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a., Fuminori Sakurai,Norihisa Furukawa,Maiko Higuchi,Sayuri Okamoto,Kaori Ono,Takeshi Yoshida,Masuo Kondoh,Kiyohito Yagi,Naoya Sakamoto,Kazufumi Katayama,Hiroyuki Mizuguchi, Virus research, Vol. 165, No. 2, p. 214-8, 2012/05
A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X., Hayato Matsui,Fuminori Sakurai,Kazufumi Katayama,Tomoko Yamaguchi,Sayuri Okamoto,Kohdai Takahira,Masashi Tachibana,Shinsaku Nakagawa,Hiroyuki Mizuguchi, Biomaterials, Vol. 33, No. 14, p. 3743-55, 2012/05
Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection., Kyoko Tomita,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Anticancer research, Vol. 32, No. 4, p. 1145-52, 2012/04
Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction., Katsuhisa Tashiro,Kenji Kawabata,Miyuki Omori,Tomoko Yamaguchi,Fuminori Sakurai,Kazufumi Katayama,Takao Hayakawa,Hiroyuki Mizuguchi, Stem cell research, Vol. 8, No. 2, p. 300-11, 2012/03
Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells, K. Iguchi,F. Sakurai,K. Tomita,K. Katayama,T. Yamaguchi,K. Kawabata,M. Tagawa,M. Kawabata,T. Shirakawa,H. Mizuguchi, CANCER GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 19, No. 2, p. 118-125, 2012/02
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters, Masaki Shoji,Shinji Yoshizaki,Hiroyuki Mizuguchi,Kenji Okuda,Masaru Shimada, PLoS ONE, Vol. 7, No. 1, 2012/01/19
Generation of metabolically functioning hepatocytes from human ES/iPS cells by FOXA2 and HNF1α transduction, TAKAYAMA Kazuo,INAMURA Mitsuru,KAWABATA Kenji,SUGAWARA Michiko,KIKUCHI Kiyomi,SAKURAI Fuminori,FURUE-KUSUDA Miho,MIZUGUCHI Hiroyuki, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. P-10, 2012
Hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells for toxicological study, MIZUGUCHI Hiroyuki, Annual Meeting of the Japanese Society of Toxicology, The Japanese Society of Toxicology, Vol. 39, p. S9-4, 2012
Efficient hepatic differentiation from human ips cells by gene transfer, Kenji Kawabata,Mitsuru Inamura,Hiroyuki Mizuguchi, Methods in Molecular Biology, Vol. 826, p. 115-124, 2012
[Perspectives regarding the potential use of human induced pluripotent stem cells for the development of and research on medicinal products]., Takao Hayakawa,Hiroyuki Mizuguchi, Brain and nerve = Shinkei kenkyu no shinpo, Vol. 64, No. 1, p. 47-57, 2012/01
Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction., Kazuo Takayama,Mitsuru Inamura,Kenji Kawabata,Kazufumi Katayama,Maiko Higuchi,Katsuhisa Tashiro,Aki Nonaka,Fuminori Sakurai,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 20, No. 1, p. 127-37, 2012/01
[Development of a novel adenovirus vector exhibiting microRNA-mediated suppression of the leaky expression of adenovirus genes]., Kahori Shimizu,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 132, No. 12, p. 1407-12, 2012
Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection., Takeshi Yoshida,Kazuo Takayama,Masuo Kondoh,Fuminori Sakurai,Hideki Tani,Naoya Sakamoto,Yoshiharu Matsuura,Hiroyuki Mizuguchi,Kiyohito Yagi, Biochemical and biophysical research communications, Vol. 416, No. 1-2, p. 119-24, 2011/12/09
Development of an adenovirus vector lacking the expression of virus-associated RNAs., Mitsuhiro Machitani,Kazufumi Katayama,Fuminori Sakurai,Hayato Matsui,Tomoko Yamaguchi,Takayuki Suzuki,Hiroyuki Miyoshi,Kenji Kawabata,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 154, No. 3, p. 285-9, 2011/09/25
EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus, Rei Kawashima,Masato Abei,Kuniaki Fukuda,Kiminori Nakamura,Takehide Murata,Mariko Wakayama,Emiko Seo,Naoyuki Hasegawa,Hiroyuki Mizuguchi,Yuichi Obata,Ichinosuke Hyodo,Hirofumi Hamada,Kazunari K. Yokoyama, International Journal of Cancer, Vol. 129, No. 5, p. 1244-1253, 2011/09/01
Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy., Xinglei Yao,Yasuo Yoshioka,Tomohiro Morishige,Yusuke Eto,Shogo Narimatsu,Yasuaki Kawai,Hiroyuki Mizuguchi,Jian-Qing Gao,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 19, No. 9, p. 1619-25, 2011/09
Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma, Kota Iwahori,Satoshi Serada,Minoru Fujimoto,Shintaro Nomura,Tadashi Osaki,Chun Man Lee,Hiroyuki Mizuguchi,Tsuyoshi Takahashi,Barry Ripley,Meinoshin Okumura,Ichiro Kawase,Tadamitsu Kishimoto,Tetsuji Naka, International Journal of Cancer, Wiley-Liss Inc., Vol. 129, No. 4, p. 993-1004, 2011/08/15
Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector., Kahori Shimizu,Fuminori Sakurai,Mitsuhiro Machitani,Kazufumi Katayama,Hiroyuki Mizuguchi, Molecular pharmaceutics, Vol. 8, No. 4, p. 1430-5, 2011/08/01
An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors., Yukari Motegi,Kazufumi Katayama,Fuminori Sakurai,Takuya Kato,Tomoko Yamaguchi,Hayato Matsui,Masahide Takahashi,Kenji Kawabata,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 153, No. 2, p. 149-53, 2011/07/30
Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses., Mitsuhiro Machitani,Tomoko Yamaguchi,Kahori Shimizu,Fuminori Sakurai,Kazufumi Katayama,Kenji Kawabata,Hiroyuki Mizuguchi, Pharmaceutics, Vol. 3, No. 3, p. 338-53, 2011/07/11
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors, Tomoko Iwata-Kajihara,Hidetoshi Sumimoto,Naoshi Kawamura,Ryo Ueda,Tomomi Takahashi,Hiroyuki Mizuguchi,Makoto Miyagishi,Kiyoshi Takeda,Yutaka Kawakami, Journal of Immunology, Vol. 187, No. 1, p. 27-36, 2011/07/01
Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome., Takayuki Suzuki,Tomomi Sasaki,Koyori Yano,Fuminori Sakurai,Kenji Kawabata,Masuo Kondoh,Takao Hayakawa,Kiyohito Yagi,Hiroyuki Mizuguchi, Virus research, Vol. 158, No. 1-2, p. 154-60, 2011/06
Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector., Kazufumi Katayama,Rie Furuki,Hideaki Yokoyama,Makoto Kaneko,Masashi Tachibana,Ichiro Yoshida,Hisamitsu Nagase,Keiichi Tanaka,Fuminori Sakurai,Hiroyuki Mizuguchi,Shinsaku Nakagawa,Tsuyoshi Nakanishi, Biomaterials, Vol. 32, No. 17, p. 4185-93, 2011/06
MicroRNA-regulated transgene expression systems for gene therapy and virotherapy., Fuminori Sakurai,Kazufumi Katayama,Hiroyuki Mizuguchi, Frontiers in bioscience (Landmark edition), Vol. 16, p. 2389-401, 2011/06/01
アデノウイルスベクターの遺伝子導入に及ぼすfiber-shaftの役割, 小泉直也,平井孝昌,藤井まき子,水口裕之,渡辺善照, Drug Delivery System, 日本DDS学会, Vol. 26, No. 3, p. 317-317, 2011/05
Adenovirus vector-mediated assay system for hepatitis C virus replication., Takeshi Yoshida,Masuo Kondoh,Manabu Ojima,Hiroyuki Mizuguchi,Yoshiaki Yamagishi,Naoya Sakamoto,Kiyohito Yagi, Nucleic acids research, Vol. 39, No. 10, 2011/05
Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences., Kumiko Sugio,Fuminori Sakurai,Kazufumi Katayama,Katsuhisa Tashiro,Hayato Matsui,Kenji Kawabata,Atsushi Kawase,Masahiro Iwaki,Takao Hayakawa,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi, Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, No. 9, p. 2807-18, 2011/05/01
Development of improved adenovirus vectors and transduction into neural cells, MATSUI Hayato,SAKURAI Fuminori,KATAYAMA Kazufumi,MIZUGUCHI Hiroyuki, Folia Pharmacologica Japonica, The Japanese Pharmacological Society, Vol. 137, No. 2, p. 70-74, 2011/02/01
Optimization of a microRNA expression vector for function analysis of microRNA, Norihisa Furukawa,Fuminori Sakurai,Kazufumi Katayama,Naohiko Seki,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 150, No. 1, p. 94-101, 2011/02
Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction., Emi Suzuki-Kouyama,Kazufumi Katayama,Fuminori Sakurai,Tomoko Yamaguchi,Shinnosuke Kurachi,Kenji Kawabata,Shinsaku Nakagawa,Hiroyuki Mizuguchi, Biomaterials, Vol. 32, No. 6, p. 1724-30, 2011/02
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX., Mitsuru Inamura,Kenji Kawabata,Kazuo Takayama,Katsuhisa Tashiro,Fuminori Sakurai,Kazufumi Katayama,Masashi Toyoda,Hidenori Akutsu,Yoshitaka Miyagawa,Hajime Okita,Nobutaka Kiyokawa,Akihiro Umezawa,Takao Hayakawa,Miho K Furue,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 19, No. 2, p. 400-7, 2011/02
Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob., Hayato Matsui,Fuminori Sakurai,Kazufumi Katayama,Shinnosuke Kurachi,Katsuhisa Tashiro,Kumiko Sugio,Kenji Kawabata,Hiroyuki Mizuguchi, Virus research, Vol. 155, No. 1, p. 48-54, 2011/01
Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction., Kazuo Takayama,Mitsuru Inamura,Kenji Kawabata,Katsuhisa Tashiro,Kazufumi Katayama,Fuminori Sakurai,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, PloS one, Vol. 6, No. 7, 2011
Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35., Fuminori Sakurai,Kazuko Nakashima,Tomoko Yamaguchi,Takako Ichinose,Kenji Kawabata,Takao Hayakawa,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 148, No. 2, p. 212-8, 2010/12/01
Differentiation of Functional Cells from iPS Cells by Efficient Gene Transfer, Kenji Kawabata,Katsuhisa Tashiro,Hiroyuki Mizuguchi, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 130, No. 11, p. 1527-1534, 2010/11
[Development of recombinant adenovirus carrying microRNA-regulated gene expression system]., Fuminori Sakurai,Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 130, No. 11, p. 1497-504, 2010/11
Induction of type I interferon by adenovirus-encoded small RNAs., Tomoko Yamaguchi,Kenji Kawabata,Emi Kouyama,Ken J Ishii,Kazufumi Katayama,Takayuki Suzuki,Shinnosuke Kurachi,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 40, p. 17286-91, 2010/10/05
Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells., Katsuhisa Tashiro,Kenji Kawabata,Mitsuru Inamura,Kazuo Takayama,Norihisa Furukawa,Fuminori Sakurai,Kazufumi Katayama,Takao Hayakawa,Miho Kusuda Furue,Hiroyuki Mizuguchi, Cellular reprogramming, Vol. 12, No. 5, p. 501-7, 2010/10
In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy, Toru Kojima,Yuichi Watanabe,Yuuri Hashimoto,Shinji Kuroda,Yasumoto Yamasaki,Shuya Yano,Masaaki Ouchi,Hiroshi Tazawa,Futoshi Uno,Shunsuke Kagawa,Satoru Kyo,Hiroyuki Mizuguchi,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, Annals of Surgery, Vol. 251, No. 6, p. 1079-1086, 2010/06
Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin., Hideki Kakutani,Masuo Kondoh,Rie Saeki,Makiko Fujii,Yoshiteru Watanabe,Hiroyuki Mizuguchi,Kiyohito Yagi, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 75, No. 2, p. 213-7, 2010/06
アデノウイルス由来Shaftタンパク質による物質取り込み機構の解明, 山岸喜彰,酒井宏,小泉直也,藤井まき子,水口裕之,渡辺善照, Drug Delivery System, 日本DDS学会, Vol. 25, No. 3, p. 314-314, 2010/05
Improving gene transfer in human renal carcinoma cells: Utilization of adenovirus vectors containing chimeric type 5 and type 35 fiber proteins, Bishnu Acharya,Shuji Terao,Toru Suzuki,Michio Naoe,Katsuyuki Hamada,Hiroyuki Mizuguchi,Akinobu Gotoh, Experimental and Therapeutic Medicine, Vol. 1, No. 3, p. 537-540, 2010/05
Particle Tracking of Intracellular Trafficking of Octaarginine-modified Liposomes: A Comparative Study With Adenovirus, Hidetaka Akita,Kaoru Enoto,Tomoya Masuda,Hiroyuki Mizuguchi,Tomomi Tani,Hideyoshi Harashima, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 18, No. 5, p. 955-964, 2010/05
Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells, Sayaka Yashima,Shinji Yoshizaki,Kaori Shinoda,Atsushi Yoshida,Asami Kondo,Hiroyuki Mizuguchi,Akihide Ryo,Kenji Okuda,Masaru Shimada, Vaccine, Vol. 28, No. 18, p. 3257-3264, 2010/04/19
Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors, Masahiro Ushitora,Fuminori Sakurai,Tomoko Yamaguchi,Shin-ichiro Nakamura,Masuo Kondoh,Kiyohito Yagi,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, Vol. 142, No. 3, p. 431-437, 2010/03
A novel translational approach for human malignant pleural mesothelioma: Heparanase-assisted dual virotherapy, Y. Watanabe,T. Kojima,S. Kagawa,F. Uno,Y. Hashimoto,S. Kyo,H. Mizuguchi,N. Tanaka,H. Kawamura,D. Ichimaru,Y. Urata,T. Fujiwara, Oncogene, Vol. 29, No. 8, p. 1145-1154, 2010/02
A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer, Michael A. Van Geer,Daniel Brevoord,Koert F. D. Kuhlmann,Conny T. Bakker,Hiroyuki Mizuguchi,John G. Wesseling,Fibo J. Ten Kate,Dirk J. Gouma,Ronald P. J. Oude Elferink,Piter J. Bosma, International Journal of Oncology, Vol. 36, No. 1, p. 233-244, 2010/01
Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models., Tomohiro Morishige,Yasuo Yoshioka,Aya Tanabe,Xinglei Yao,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, International immunopharmacology, Vol. 10, No. 1, p. 26-33, 2010/01
Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration., Xinglei Yao,Yasuo Yoshioka,Tomohiro Morishige,Yusuke Eto,Shogo Narimatsu,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biological & pharmaceutical bulletin, Vol. 33, No. 6, p. 1073-6, 2010
Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer., Yusuke Eto,Yasuo Yoshioka,Tatsuhiro Ishida,Xinglei Yao,Tomohiro Morishige,Shogo Narimatsu,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Hiroshi Kiwada,Shinsaku Nakagawa, Biological & pharmaceutical bulletin, Vol. 33, No. 9, p. 1540-4, 2010
Efficient differentiation methods of stem cells by gene transfer, TASHIRO Katsuhisa,INAMURA Mitsuru,KAWABATA Kenji,MIZUGUCHI Hiroyuki, TISSUE CULTURE RESEARCH COMMUNICATIONS, The Japanese Tissue Culture Association, Vol. 28, No. 2, p. 135-143, 2009/12/31
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis, X. Yao,Y. Yoshioka,T. Morishige,Y. Eto,H. Watanabe,Y. Okada,H. Mizuguchi,Y. Mukai,N. Okada,S. Nakagawa, GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 16, No. 12, p. 1395-1404, 2009/12
REDUCTION OF VECTOR-INDUCED INNATE IMMUNITY BY SOCS1-EXPRESSING ADENOVIRUS VECTOR, Kawabata Kenji,Sakurai Haruna,Tashiro Katsuhisa,Yamaguchi Tomoko,Sakurai Fuminori,Nakagawa Shinsaku,Mizuguchi Hiroyuki, JOURNAL OF GENE MEDICINE, Vol. 11, No. 12, p. 1170-1171, 2009/12
A simple biological imaging system for detecting viable human circulating tumor cells, Toru Kojima,Yuuri Hashimoto,Yuichi Watanabe,Shunsuke Kagawa,Futoshi Uno,Shinji Kuroda,Hiroshi Tazawa,Satoru Kyo,Hiroyuki Mizuguchi,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 119, No. 10, p. 3172-3181, 2009/10
Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors, Hong Xin,Ruowen Sun,Masahiko Kanehira,Takenori Takahata,Jugoh Itoh,Hiroyuki Mizuguchi,Yasuo Saijo, Molecular Medicine, Vol. 15, No. 9-10, p. 321-327, 2009/09
Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif, Shuji Terao,Bishnu Acharya,Toru Suzuki,Takashi Aoi,Michio Naoe,Katsuyuki Hamada,Hiroyuki Mizuguchi,Akinobu Gotoh, Anticancer Research, Vol. 29, No. 8, p. 2997-3001, 2009/08
Transduction of adenovirus vectors modified with cell-penetrating peptides., Yusuke Eto,Yasuo Yoshioka,Ratima Asavatanabodee,Shinya Kida,Mitsuko Maeda,Yohei Mukai,Hiroyuki Mizuguchi,Koichi Kawasaki,Naoki Okada,Shinsaku Nakagawa, Peptides, Vol. 30, No. 8, p. 1548-52, 2009/08
Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction., Katsuhisa Tashiro,Mitsuru Inamura,Kenji Kawabata,Fuminori Sakurai,Koichi Yamanishi,Takao Hayakawa,Hiroyuki Mizuguchi, Stem cells (Dayton, Ohio), Vol. 27, No. 8, p. 1802-11, 2009/08
Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5, Shinya Abe,Kenji Okuda,Takehiro Ura,Asami Kondo,Atsushi Yoshida,Shinji Yoshizaki,Hiroyuki Mizuguchi,Dennis Klinman,Masaru Shimada, JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Vol. 11, No. 7, p. 570-579, 2009/07
Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo, Michael A. van Geer,Conny T. Bakker,Naoya Koizumi,Hiroyuki Mizuguchi,John G. Wesseling,Ronald P. J. Oude Elferink,Piter J. Bosma, WORLD JOURNAL OF GASTROENTEROLOGY, W J G PRESS, Vol. 15, No. 22, p. 2754-2762, 2009/06
Telomerase-specific virotheranostics for human head and neck cancer, Yuji Kurihara,Yuichi Watanabe,Hideki Onimatsu,Toru Kojima,Tatsuo Shirota,Masashi Hatori,Dong Liu,Satoru Kyo,Hiroyuki Mizuguchi,Yasuo Urata,Satoru Shintani,Toshiyoshi Fujiwara, Clinical Cancer Research, Vol. 15, No. 7, p. 2335-2343, 2009/04/01
NK cells are migrated and indispensable in the anti-tumor activity induced by CCL27 gene therapy., Jian-Qing Gao,Yasuhiro Tsuda,Min Han,Dong-Hang Xu,Naoko Kanagawa,Yutaka Hatanaka,Yoichi Tani,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Tadanori Mayumi,Naoki Okada,Shinsaku Nakagawa, Cancer immunology, immunotherapy : CII, Vol. 58, No. 2, p. 291-9, 2009/02
Efficient osteoblast differentiation from mouse bone marrow stromal cells with polylysin-modified adenovirus vectors., Katsuhisa Tashiro,Asami Kondo,Kenji Kawabata,Haruna Sakurai,Fuminori Sakurai,Koichi Yamanishi,Takao Hayakawa,Hiroyuki Mizuguchi, Biochemical and biophysical research communications, Vol. 379, No. 1, p. 127-32, 2009/01/30
Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob, H. Matsui,F. Sakurai,S. Kurachi,K. Tashiro,K. Sugio,K. Kawabata,K. Yamanishi,H. Mizuguchi, Gene Therapy, Vol. 16, No. 8, p. 1050-1057, 2009
Designed recombinant adenovirus type 5 vector induced envelope-specific CD8+ cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1, Takehiro Ura,Atsushi Yoshida,Ke-Qin Xin,Shinji Yoshizaki,Sayaka Yashima,Shinya Abe,Hiroyuki Mizuguchi,Kenji Okuda, Journal of Gene Medicine, Vol. 11, No. 2, p. 139-149, 2009
Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates, F. Sakurai,S. I. Nakamura,K. Akitomo,H. Shibata,K. Terao,K. Kawabata,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 16, No. 2, p. 297-302, 2009
Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV infection of rhesus monkeys undergoing antiretroviral therapy, M. Shimada,H. B. Wang,A. Kondo,X. P. Xu,A. Yoshida,K. Shinoda,T. Ura,H. Mizuguchi,D. Klinman,J. L. Luo,H. Bai,K. Okuda, Gene Therapy, Nature Publishing Group, Vol. 16, No. 2, p. 218-228, 2009
Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses., Huang H,Sakurai F,Higuchi Y,Kawakami S,Hashida M,Kawabata K,Mizuguchi H, Journal of controlled release : official journal of the Controlled Release Society, 2, Vol. 133, p. 139-145, 2009/01
[Development of pegylated adenovirus vector for cancer gene therapy]., Yusuke Eto,Yasuo Yoshioka,Ratima Asavatanabodee,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 128, No. 12, p. 1733-42, 2008/12
Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency., Yasuo Yoshioka,Ratima Asavatanabodee,Yusuke Eto,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinya Kida,Mitsuko Maeda,Yohei Mukai,Hiroyuki Mizuguchi,Koichi Kawasaki,Naoki Okada,Shinsaku Nakagawa, Life sciences, Vol. 83, No. 21-22, p. 747-55, 2008/11/21
Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses., Jian-Qing Gao,Naoko Kanagawa,Dong-Hang Xu,Min Han,Toshiki Sugita,Yutaka Hatanaka,Yoichi Tani,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Tadanori Mayumi,Naoki Okada,Shinsaku Nakagawa, Cancer immunology, immunotherapy : CII, Vol. 57, No. 11, p. 1657-64, 2008/11
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy., Suzuki T,Sakurai F,Nakamura S,Kouyama E,Kawabata K,Kondoh M,Yagi K,Mizuguchi H, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 16, No. 10, p. 1719-1726, 2008/10
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy., Takayuki Suzuki,Fuminori Sakurai,Shin-Ichiro Nakamura,Emi Kouyama,Kenji Kawabata,Masuo Kondoh,Kiyohito Yagi,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 16, No. 10, p. 1719-1726, 2008/10
テロメアーゼ特異的制限増殖型アデノウイルスによる末梢血中ヒトがん細胞検出方法の開発(A three-step simple imaging method to detect viable human circulating tumor cells in the peripheral blood), 橋本悠里,児島亨,渡邉雄一,黒田新士,宇野太,香川俊輔,水口裕之,浦田泰生,田中紀章,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 67回, p. 486-486, 2008/09
Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors., Eri Arita,Masuo Kondoh,Katsuhiro Isoda,Hikaru Nishimori,Takeshi Yoshida,Hiroyuki Mizuguchi,Kiyohito Yagi, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Vol. 70, No. 1, p. 1-6, 2008/09
Efficient gene delivery in human and rodent mast cells using adenovirus vectors., Kazuko Nakashima,Fuminori Sakurai,Kenji Kawabata,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 129, No. 3, p. 215-22, 2008/08/07
Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants., Naoko Kanagawa,Ryosuke Koretomo,Sayaka Murakami,Fuminori Sakurai,Hiroyuki Mizuguchi,Shinsaku Nakagawa,Takuya Fujita,Akira Yamamoto,Naoki Okada, Virology, Vol. 374, No. 2, p. 411-20, 2008/05/10
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus, KISHIMOTO Hiroyuki,KOJIMA Toru,WATANABE Yuichi,KAGAWA Shunsuke,FUJIWARA Toshiya,UNO Futoshi,TERAISHI Fuminori,KYO Satoru,MIZUGUCHI Hiroyuki,HASHIMOTO Yuuri,URATA Yasuo,TANAKA Noriaki,FUJIWARA Toshiyoshi, Vol. 120, No. 1, p. 13-21, 2008/05/01
アデノウイルスカプシド蛋白質を利用した効率的遺伝子導入法の開発, 小泉直也,萩原恵理,岩島順子,山岸喜彰,水口裕之,藤井まき子,渡辺善照, Drug Delivery System, 日本DDS学会, Vol. 23, No. 3, p. 360-360, 2008/05
Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation., Katsuhisa Tashiro,Kenji Kawabata,Haruna Sakurai,Shinnosuke Kurachi,Fuminori Sakurai,Koichi Yamanishi,Hiroyuki Mizuguchi, The journal of gene medicine, Vol. 10, No. 5, p. 498-507, 2008/05
Innate immune response induced by gene delivery vectors., Haruna Sakurai,Kenji Kawabata,Fuminori Sakurai,Shinsaku Nakagawa,Hiroyuki Mizuguchi, International journal of pharmaceutics, Vol. 354, No. 1-2, p. 9-15, 2008/04/16
Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis., Azusa Takahashi,Eriko Komiya,Hideki Kakutani,Takeshi Yoshida,Makiko Fujii,Yasuhiko Horiguchi,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Shin-ichi Tsunoda,Naoya Koizumi,Katsuhiro Isoda,Kiyohito Yagi,Yoshiteru Watanabe,Masuo Kondoh, Biochemical pharmacology, Vol. 75, No. 8, p. 1639-48, 2008/04/15
Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors., Shinnosuke Kurachi,Naoya Koizumi,Katsuhisa Tashiro,Haruna Sakurai,Fuminori Sakurai,Kenji Kawabata,Shinsaku Nakagawa,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 127, No. 1, p. 88-95, 2008/04/07
Generation of fiber-modified adenovirus vectors containing the tat peptide in the fiber knob, Kurachi Shinnosuke,Tashiro Katsuhisa,Sakurai Haruna,Sakurai Fuminori,Kawabata Kenji,Yayama Katsutoshi,Okamoto Hiroshi,Nakagawa Shinsaku,Mizuguchi Hiroyuki, JOURNAL OF GENE MEDICINE, Vol. 10, No. 4, 2008/04
Analysis of gene expression profile involved in the innate immune response by adenovirus vector, Sakurai Haruna,Igarashi Katsuhide,Tashiro Katsuhisa,Kawabata Kenji,Sakurai Fuminori,Kurachi Shinnosuke,Nakagawa Shinsaku,Aisaki Ken-ichi,Kanno Jun,Mizuguchi Hiroyuki, JOURNAL OF GENE MEDICINE, Vol. 10, No. 4, 2008/04
Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune responses., Haruna Sakurai,Katsuhisa Tashiro,Kenji Kawabata,Tomoko Yamaguchi,Fuminori Sakurai,Shinsaku Nakagawa,Hiroyuki Mizuguchi, Journal of immunology (Baltimore, Md. : 1950), Vol. 180, No. 7, p. 4931-8, 2008/04/01
Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates., Fuminori Sakurai,Shin-ichiro Nakamura,Kimiyo Akitomo,Hiroaki Shibata,Keiji Terao,Kenji Kawabata,Takao Hayakawa,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 16, No. 4, p. 726-33, 2008/04
Transduction Properties of Adenovirus Serotype 35 Vectors After Intravenous Administration Into Nonhuman Primates., Fuminori Sakurai,Shin-Ichiro Nakamura,Kimiyo Akitomo,Hiroaki Shibata,Keiji Terao,Kenji Kawabata,Takao Hayakawa,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 16, No. 4, p. 726-733, 2008/04
Downregulation of CD46 during muscle differentiation: Implications for gene transfer to human skeletal muscle using group B adenoviruses, Nancy Larochelle,Jatinderpal R. Deol,Vinit Srivastava,Carol Allen,Hiroyuki Mizuguchi,George Karpati,Paul C. Holland,Josephine Nalbantoglu, HUMAN GENE THERAPY, MARY ANN LIEBERT INC, Vol. 19, No. 2, p. 133-142, 2008/02
Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells, S. Murakami,F. Sakurai,K. Kawabata,N. Okada,T. Fujita,A. Yamamoto,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 14, No. 21, p. 1525-1533, 2007/11
Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells, M. Kanehira,H. Xin,K. Hoshino,M. Maemondo,H. Mizuguchi,T. Hayakawa,K. Matsumoto,T. Nakamura,T. Nukiwa,Y. Saijo, Cancer Gene Therapy, Vol. 14, No. 11, p. 894-903, 2007/11
Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys, Kenji Someya,Ke-Qin Xin,Yasushi Ami,Yasuyuki Izumi,Hiroyuki Mizuguchi,Shinrai Ohta,Naoki Yamamoto,Mitsuo Honda,Kenji Okuda, Virology, Vol. 367, No. 2, p. 390-397, 2007/10/25
TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection., Xinglei Yao,Yasuo Yoshioka,Yusuke Eto,Tomohiro Morishige,Yuka Okada,Hiroyuki Mizuguchi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, Biochemical and biophysical research communications, Vol. 362, No. 2, p. 419-24, 2007/10/19
Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells., Manabu Yamashita,Asami Ino,Kenji Kawabata,Fuminori Sakurai,Hiroyuki Mizuguchi, International journal of cancer, Vol. 121, No. 8, p. 1690-6, 2007/10/15
Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration., Jian-Qing Gao,Yusuke Eto,Yasuo Yoshioka,Fumiko Sekiguchi,Shinnosuke Kurachi,Tomohiro Morishige,Xinglei Yao,Hikaru Watanabe,Ratima Asavatanabodee,Fuminori Sakurai,Hiroyuki Mizuguchi,Yuka Okada,Yohei Mukai,Yasuo Tsutsumi,Tadanori Mayumi,Naoki Okada,Shinsaku Nakagawa, Journal of controlled release : official journal of the Controlled Release Society, Vol. 122, No. 1, p. 102-10, 2007/09/11
Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP, K. Kawabata,K. Tashiro,F. Sakurai,N. Osada,J. Kusuda,T. Hayakawa,K. Yamanishi,H. Mizuguchi, Gene Therapy, Vol. 14, No. 16, p. 1199-1207, 2007/08
Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors., Tomoko Yamaguchi,Kenji Kawabata,Naoya Koizumi,Fuminori Sakurai,Kazuko Nakashima,Haruna Sakurai,Tomomi Sasaki,Naoki Okada,Koichi Yamanishi,Hiroyuki Mizuguchi, Human gene therapy, Vol. 18, No. 8, p. 753-62, 2007/08
Adenovirus vectors composed of subgroup B adenoviruses., Fuminori Sakurai,Kenji Kawabata,Hiroyuki Mizuguchi, Current gene therapy, Vol. 7, No. 4, p. 229-38, 2007/08
Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells., Hong Xin,Masahiko Kanehira,Hiroyuki Mizuguchi,Takao Hayakawa,Toshiaki Kikuchi,Toshihiro Nukiwa,Yasuo Saijo, Stem cells (Dayton, Ohio), Vol. 25, No. 7, p. 1618-26, 2007/07
Downregulation of human CD46 by adenovirus serotype 35 vectors, F. Sakurai,K. Akitomo,K. Kawabata,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 14, No. 11, p. 912-919, 2007/06
Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation., Akie Moriuchi,Hironori Yamasaki,Mika Shimamura,Atsushi Kita,Hironaga Kuwahara,Keiichiro Fujishima,Tsuyoshi Satoh,Keiko Fukushima,Tetsuya Fukushima,Takao Hayakawa,Hiroyuki Mizuguchi,Yuji Nagayama,Norio Abiru,Eiji Kawasaki,Katsumi Eguchi, Biochemical and biophysical research communications, Vol. 356, No. 4, p. 1024-30, 2007/05/18
Efficient gene transfer into murine pancreatic islets using adenovirus vectors., Eri Mukai,Shimpei Fujimoto,Fuminori Sakurai,Kenji Kawabata,Manabu Yamashita,Nobuya Inagaki,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 119, No. 1, p. 136-41, 2007/05/14
Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV, Ke-Qin Xin,Yuka Sekimoto,Toru Takahashi,Hiroyuki Mizuguchi,Motohide Ichino,Atsushi Yoshida,Kenji Okuda, Vaccine, Vol. 25, No. 19, p. 3809-3815, 2007/05/10
Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex, Susumu Hama,Hidetaka Akita,Shinya Iida,Hiroyuki Mizuguchi,Hideyoshi Harashima, Nucleic Acids Research, Vol. 35, No. 5, p. 1533-1543, 2007/03
Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer, J. Q. Gao,N. Kanagawa,Y. Motomura,T. Yanagawa,T. Sugita,Y. Hatanaka,Y. Tani,H. Mizuguchi,Y. Tsutsumi,T. Mayumi,N. Okada,S. Nakagawa, Gene Therapy, Vol. 14, No. 6, p. 491-502, 2007/03
Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex., Haruna Sakurai,Fuminori Sakurai,Kenji Kawabata,Tomomi Sasaki,Naoya Koizumi,Haiying Huang,Katsuhisa Tashiro,Shinnosuke Kurachi,Shinsaku Nakagawa,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 117, No. 3, p. 430-7, 2007/02/26
Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon, S. Kurachi,N. Koizumi,F. Sakurai,K. Kawabata,H. Sakurai,S. Nakagawa,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 14, No. 3, p. 266-274, 2007/02
Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production., Naoya Koizumi,Tomoko Yamaguchi,Kenji Kawabata,Fuminori Sakurai,Tomomi Sasaki,Yoshiteru Watanabe,Takao Hayakawa,Hiroyuki Mizuguchi, Journal of immunology (Baltimore, Md. : 1950), Vol. 178, No. 3, p. 1767-73, 2007/02/01
Gene delivery into stem cells by modified adenovirus vectors, Kenji Kawabata,Fuminori Sakurai,Hiroyuki Mizuguchi, Drug Delivery System, Vol. 22, No. 2, p. 148-154, 2007
Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs., Hiroyuki Mizuguchi,Naoko Funakoshi,Tetsuji Hosono,Fuminori Sakurai,Kenji Kawabata,Teruhide Yamaguchi,Takao Hayakawa, Human gene therapy, Vol. 18, No. 1, p. 74-80, 2007/01
Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells, Maki Kamakura,Keiko Morisawa,Hideyuki Komi,Ayako Tomatani,Fumiji Saito,Yuko Konishi,Ya Jin,Takashi Manabe,Masayuki Kuroda,Shosuke Imai,Hiroyuki Mizuguchi,Taketoshi Taniguchi, Biochemical and Biophysical Research Communications, Vol. 349, No. 4, p. 1372-1377, 2006/11/03
Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector, Hidetaka Akita,Susumu Hama,Hiroyuki Mizuguchi,Hideyoshi Harashima, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, Vol. 126, No. 11, p. 1047-1057, 2006/11
[Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus vector]., Jian-qing Gao,Hai-liang Chen,Shinsaku Nakagawa,Hiroyuki Mizuguchi,Wen-quan Liang, Yao xue xue bao = Acta pharmaceutica Sinica, Vol. 41, No. 11, p. 1116-20, 2006/11
[Recent advance in development of viral and non-viral vectors for gene therapy]., Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 126, No. 11, p. 1011-1011, 2006/11
[Characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates]., Fuminori Sakurai,Kenji Kawabata,Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 126, No. 11, p. 1013-9, 2006/11
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus, Hiroyuki Kishimoto,Toru Kojima,Yuichi Watanabe,Shunsuke Kagawa,Toshiya Fujiwara,Futoshi Uno,Fuminori Teraishi,Satoru Kyo,Hiroyuki Mizuguchi,Yuuri Hashimoto,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 12, No. 10, p. 1213-1219, 2006/10
Characteristics of Transcription-regulatory Elements for Gene Expression from Plasmid Vectors in Human Trophoblast Cell Lines, E. Komiya,M. Kondoh,H. Mizuguchi,M. Fujii,N. Utoguchi,T. Nakanishi,Y. Watanabe, Placenta, Vol. 27, No. 9-10, p. 934-938, 2006/09
The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35., Fuminori Sakurai,Sayaka Murakami,Kenji Kawabata,Naoki Okada,Akira Yamamoto,Tsukasa Seya,Takao Hayakawa,Hiroyuki Mizuguchi, Journal of controlled release : official journal of the Controlled Release Society, Vol. 113, No. 3, p. 271-8, 2006/07/20
Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice, F. Sakurai,K. Kawabata,N. Koizumi,N. Inoue,M. Okabe,T. Yamaguchi,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 13, No. 14, p. 1118-1126, 2006/07
Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus, Takahiro Fujiwara,Hidetaka Akita,Katsuko Furukawa,Takashi Ushida,Hiroyuki Mizuguchi,Hideyoshi Harashima, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 29, No. 7, p. 1511-1515, 2006/07
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity, Kenji Uno,Hideki Katagiri,Tetsuya Yamada,Yasushi Ishigaki,Takehide Ogihara,Junta Imai,Yutaka Hasegawa,Junhong Gao,Keizo Kaneko,Hiroko Iwasaki,Hisamitsu Ishihara,Hironobu Sasano,Kouichi Inukai,Hiroyuki Mizuguchi,Tomoichiro Asano,Masakazu Shiota,Masamitsu Nakazato,Yoshitomo Oka, Science, Vol. 312, No. 5780, p. 1656-1659, 2006/06/16
Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of α vβ 3 integrins, Airi Harui,Michael D. Roth,Darshni Vira,Mihir Sanghvi,Hiroyuki Mizuguchi,Saroj K. Basak, Journal of Leukocyte Biology, Vol. 79, No. 6, p. 1271-1278, 2006/06
Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein., Naoya Koizumi,Hiroyuki Mizuguchi,Masuo Kondoh,Makiko Fujii,Tsuyoshi Nakanishi,Naoki Utoguchi,Yoshiteru Watanabe, Biological & pharmaceutical bulletin, Vol. 29, No. 6, p. 1297-9, 2006/06
Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors, Airi Harui,Michael D. Roth,Mihir Sanghvi,Darshni Vira,Hiroyuki Mizuguchi,Saroj K. Basak, Journal of Immunological Methods, Vol. 312, No. 1-2, p. 94-104, 2006/05/30
Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector, N Okada,A Sasaki,M Niwa,Y Okada,Y Hatanaka,Y Tani,H Mizuguchi,S Nakagawa,T Fujita,A Yamamoto, CANCER GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 13, No. 4, p. 393-405, 2006/04
Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems., Susumu Hama,Hidetaka Akita,Rie Ito,Hiroyuki Mizuguchi,Takao Hayakawa,Hideyoshi Harashima, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 13, No. 4, p. 786-94, 2006/04
Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors., Mio Nukiwa,Sita Andarini,Jamal Zaini,Hong Xin,Masahiko Kanehira,Takuji Suzuki,Tatsuro Fukuhara,Hiroyuki Mizuguchi,Takao Hayakawa,Yasuo Saijo,Toshihiro Nukiwa,Toshiaki Kikuchi, European journal of immunology, Vol. 36, No. 4, p. 1019-27, 2006/04
Adenovirus vector-mediated gene transfer into stem cells, Kenji Kawabata,Funlinori Sakurai,Naoya Koizumi,Takao Hayakawa,Hiroyuki Mizuguchi, MOLECULAR PHARMACEUTICS, AMER CHEMICAL SOC, Vol. 3, No. 2, p. 95-103, 2006/03
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity., Naoya Koizumi,Kenji Kawabata,Fuminori Sakurai,Yoshiteru Watanabe,Takao Hayakawa,Hiroyuki Mizuguchi, Human gene therapy, Vol. 17, No. 3, p. 264-79, 2006/03
Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells., Shinya Kida,Mitsuko Maeda,Keiko Hojo,Yusuke Eto,Jian-Qing Gao,Shinnosuke Kurachi,Hiroyuki Mizuguchi,Takao Hayakawa,Tadanori Mayumi,Shinsaku Nakagawa,Koichi Kawasaki, Bioorganic & medicinal chemistry letters, Vol. 16, No. 3, p. 743-5, 2006/02
Quantitative comparison of intracellular trafficking between artificial and viral vector: Mechanism underlying the difference in dominant rate-limiting process, Hidetaka Akita,Susumu Hama,Hiroyuki Mizuguchi,Hideyoshi Harashima, Progress on Post-Genome Technologies, SOUTHEAST UNIV PRESS, p. 521-525, 2006
Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin., Chiaki Ebihara,Masuo Kondoh,Naoki Hasuike,Motoki Harada,Hiroyuki Mizuguchi,Yasuhiko Horiguchi,Makiko Fujii,Yoshiteru Watanabe, The Journal of pharmacology and experimental therapeutics, Vol. 316, No. 1, p. 255-60, 2006/01
Synthesis of a RGD peptide-PEG hybrid for carrying adenovirus vector into cells, Shinya Kida,Mitsuko Maeda,Keiko Hojo,Yusuke Eto,Jian-Qing Gao,Shinnosuke Kurachi,Fumiko Sekiguchi,Hiroyuki Mizuguchi,Takao Hayakawa,Tadanori Mayumi,Shinsaku Nakagawa,Koichi Kawasaki, UNDERSTANDING BIOLOGY USING PEPTIDES, SPRINGER, p. 497-+, 2006
Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system., Hiroyuki Mizuguchi,Zhi-Li Xu,Fuminori Sakurai,Kenji Kawabata,Teruhide Yamaguchi,Takao Hayakawa, Journal of controlled release : official journal of the Controlled Release Society, Vol. 110, No. 1, p. 202-11, 2005/12/10
Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV, K. Q. Xin,N. Jounai,K. Someya,K. Honma,H. Mizuguchi,S. Naganawa,K. Kitamura,T. Hayakawa,S. Saha,F. Takeshita,K. Okuda,M. Honda,D. M. Klinman,K. Okuda, Gene Therapy, Vol. 12, No. 24, p. 1769-1777, 2005/12
Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4., Azusa Takahashi,Masuo Kondoh,Akane Masuyama,Makiko Fujii,Hiroyuki Mizuguchi,Yasuhiko Horiguchi,Yoshiteru Watanabe, Journal of controlled release : official journal of the Controlled Release Society, Vol. 108, No. 1, p. 56-62, 2005/11/02
Comparison of transgene expression mediated by several Fiber-modified adenovirus vectors in trophoblast cells, N. Koizumi,M. Kondoh,H. Mizuguchi,T. Nakanishi,A. Masuyama,F. Ida,M. Fujii,T. Hayakawa,E. Nakashima,K. Tanaka,Y. Watanabe, Placenta, Vol. 26, No. 10, p. 729-734, 2005/11
A trial of somatic gene targeting in vivo with an adenovirus vector., Asami Ino,Yasuhiro Naito,Hiroyuki Mizuguchi,Naofumi Handa,Takao Hayakawa,Ichizo Kobayashi, Genetic vaccines and therapy, Vol. 3, p. 8-8, 2005/10/12
Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: Comparison of promoter activities, F. Sakurai,K. Kawabata,T. Yamaguchi,T. Hayakawa,H. Mizuguchi, Gene Therapy, Vol. 12, No. 19, p. 1424-1433, 2005/10
Efficient gene transfer into hematopoietic stem cell, mesenchymal stem cell, and ES cell by modified adenovirus vectors, MIZUGUCHI Hiroyuki,KAWABATA Kenji,SAKURAI Fuminori,HAYAKAWA Takao, Ensho, The Japanese Society of Inflammation and Regeneration, Vol. 25, No. 5, p. 447-451, 2005/09/25
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors., Kenji Kawabata,Fuminori Sakurai,Teruhide Yamaguchi,Takao Hayakawa,Hiroyuki Mizuguchi, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 12, No. 3, p. 547-54, 2005/09
Role of N-terminal amino acids in the absorption-enhancing effects of the c-terminal fragment of Clostridium perfringens enterotoxin., Akane Masuyama,Masuo Kondoh,Hirotoshi Seguchi,Azusa Takahashi,Motoki Harada,Makiko Fujii,Hiroyuki Mizuguchi,Yasuhiko Horiguchi,Yoshiteru Watanabe, The Journal of pharmacology and experimental therapeutics, Vol. 314, No. 2, p. 789-95, 2005/08
Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cells., Hiroyuki Mizuguchi,Tomomi Sasaki,Kenji Kawabata,Fuminori Sakurai,Takao Hayakawa, Biochemical and biophysical research communications, Vol. 332, No. 4, p. 1101-6, 2005/07/15
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma., Yuka Okada,Naoki Okada,Hiroyuki Mizuguchi,Takao Hayakawa,Shinsaku Nakagawa,Tadanori Mayumi, Cancer gene therapy, Vol. 12, No. 7, p. 608-16, 2005/07
Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector., Jian-Qing Gao,Toshiki Sugita,Naoko Kanagawa,Keisuke Iida,Naoki Okada,Hiroyuki Mizuguchi,Takashi Nakayama,Takao Hayakawa,Osamu Yoshie,Yasuo Tsutsumi,Tadanori Mayumi,Shinsaku Nakagawa, Biological & pharmaceutical bulletin, Vol. 28, No. 6, p. 1066-70, 2005/06
タイトジャンクション(TJ)構成蛋白質claudinを利用した新規DDS方法の確立, 高橋梓,近藤昌夫,増山茜,原田東樹,藤井まき子,水口裕之,渡辺善照, Drug Delivery System, 日本DDS学会, Vol. 20, No. 3, p. 314-314, 2005/05
ポリエチレングリコール修飾アデノウイルスベクターのEPR効果に関する検討, 森重智弘,衛藤佑介,倉知慎之輔,姚醒蕾,水口裕之,堤康央,早川尭夫,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 20, No. 3, p. 341-341, 2005/05
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability., Yusuke Eto,Jian-Qing Gao,Fumiko Sekiguchi,Shinnosuke Kurachi,Kazufumi Katayama,Mitsuko Maeda,Koichi Kawasaki,Hiroyuki Mizuguchi,Takao Hayakawa,Yasuo Tsutsumi,Tadanori Mayumi,Shinsaku Nakagawa, The journal of gene medicine, Vol. 7, No. 5, p. 604-12, 2005/05
Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')., Masaki Taki,Shunsuke Kagawa,Masahiko Nishizaki,Hiroyuki Mizuguchi,Takao Hayakawa,Satoru Kyo,Katsuyuki Nagai,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, Oncogene, Vol. 24, No. 19, p. 3130-40, 2005/04/28
Approaches to improving the kinetics of adenovirus-delivered genes and gene products., Zhi-Li Xu,Hiroyuki Mizuguchi,Fuminori Sakurai,Naoya Koizumi,Tetsuji Hosono,Kenji Kawabata,Yoshiteru Watanabe,Teruhide Yamaguchi,Takao Hayakawa, Advanced drug delivery reviews, Vol. 57, No. 5, p. 781-802, 2005/04/05
Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1., Md Nasimuzzaman,Masayuki Kuroda,Sumitaka Dohno,Takenobu Yamamoto,Keiji Iwatsuki,Shigenobu Matsuzaki,Rashel Mohammad,Wakako Kumita,Hiroyuki Mizuguchi,Takao Hayakawa,Hiroyuki Nakamura,Takahiro Taguchi,Hiroshi Wakiguchi,Shosuke Imai, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 11, No. 4, p. 578-90, 2005/04
RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells., Tetsuji Hosono,Hiroyuki Mizuguchi,Kazufumi Katayama,Naoya Koizumi,Kenji Kawabata,Teruhide Yamaguchi,Shinsaku Nakagawa,Yoshiteru Watanabe,Tadanori Mayumi,Takao Hayakawa, Gene, Vol. 348, p. 157-65, 2005/03/28
A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma., Jian-Qing Gao,Toshiki Sugita,Naoko Kanagawa,Keisuke Iida,Yusuke Eto,Yoshiaki Motomura,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Takao Hayakawa,Tadanori Mayumi,Shinsaku Nakagawa, Biochemical and biophysical research communications, Vol. 328, No. 4, p. 1043-50, 2005/03/25
A novel strategy for the enhancement of drug absorption using a claudin modulator., Masuo Kondoh,Akane Masuyama,Azusa Takahashi,Nagayoshi Asano,Hiroyuki Mizuguchi,Naoya Koizumi,Makiko Fujii,Takao Hayakawa,Yasuhiko Horiguchi,Yoshiteru Watanbe, Molecular pharmacology, Vol. 67, No. 3, p. 749-56, 2005/03
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells., Mitsuko Maeda,Shinya Kida,Keiko Hojo,Yusuke Eto,Jian-Qing Gaob,Shinnosuke Kurachi,Fumiko Sekiguchi,Hiroyuki Mizuguchi,Takao Hayakawa,Tadanori Mayumi,Shinsaku Nakagawa,Koichi Kawasaki, Bioorganic & medicinal chemistry letters, Vol. 15, No. 3, p. 621-4, 2005/02/01
Constitutively active PDX1 induced efficient insulin production in adult murine liver, Junta Imai,Hideki Katagiri,Tetsuya Yamada,Yasushi Ishigaki,Takehide Ogihara,Kenji Uno,Yutaka Hasegawa,Junhong Gao,Hisamitsu Ishihara,Hironobu Sasano,Hiroyuki Mizuguchi,Tomoichiro Asano,Yoshitomo Oka, Biochemical and Biophysical Research Communications, Vol. 326, No. 2, p. 402-409, 2005/01/14
Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference, H. Sumimoto,S. Yamagata,A. Shimizu,H. Miyoshi,H. Mizuguchi,T. Hayakawa,M. Miyagishi,K. Taira,Y. Kawakami, Gene Therapy, Vol. 12, No. 1, p. 95-100, 2005/01
Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction, Naoki Okada,Naoki Mori,Ryosuke Koretomo,Yuka Okada,Takashi Nakayama,Osamu Yoshie,Hiroyuki Mizuguchi,Takao Hayakawa,Shinsaku Nakagawa,Tadanori Mayumi,Takuya Fujita,Akira Yamamoto, Gene Ther., NATURE PUBLISHING GROUP, Vol. 12, No. 2, p. 129-139, 2005/01
Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12., Naoki Okada,Sayaka Iiyama,Yuka Okada,Hiroyuki Mizuguchi,Takao Hayakawa,Shinsaku Nakagawa,Tadanori Mayumi,Takuya Fujita,Akira Yamamoto, Cancer gene therapy, Vol. 12, No. 1, p. 72-83, 2005/01
Efficient gene transfer into human trophoblast cells with adenovirus vector containing chimeric type 5 and 35 fiber protein., Naoya Koizumi,Hiroyuki Mizuguchi,Masuo Kondoh,Makiko Fujii,Takao Hayakawa,Yoshiteru Watanabe, Biological & pharmaceutical bulletin, Vol. 27, No. 12, p. 2046-8, 2004/12
Targeted adenovirus vectors., Hiroyuki Mizuguchi,Takao Hayakawa, Human gene therapy, Vol. 15, No. 11, p. 1034-44, 2004/11
GFP発現テロメラーゼ特異的制限増殖型ウイルスTelomelysin-GFPを用いた腫瘍組織ナビゲーション・システム, 岸本浩行,香川俊輔,滝正樹,藤原俊哉,渡辺貴紀,遠藤芳克,京哲,水口裕之,田中紀章,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 63回, p. 454-454, 2004/09
HDAC阻害剤FR901228によるテロメラーゼ特異的制限増殖型アデノウイルスTelomelysinの選択的抗腫瘍効果の増強, 渡邉貴紀,西崎正彦,香川俊輔,滝正樹,岸本浩行,藤原俊哉,遠藤芳克,京哲,水口裕之,田中紀章,藤原俊義, 日本癌学会総会記事, (一社)日本癌学会, Vol. 63回, p. 499-499, 2004/09
テロメラーゼ特異的制限増殖型アデノウイルスTelomelysinと微小管作用型抗癌剤の併用効果の検討, 藤原俊哉,藤原俊義,香川俊輔,滝正樹,岸本浩行,渡邉貴紀,遠藤芳克,京哲,水口裕之,田中紀章, 日本癌学会総会記事, (一社)日本癌学会, Vol. 63回, p. 510-510, 2004/09
An improved method for detection of replication-competent retrovirus in retrovirus vector products., Eriko Uchida,Koei Sato,Akiko Iwata,Akiko Ishii-Watabe,Hiroyuki Mizuguchi,Mikio Hikata,Mitsuhiro Murata,Teruhide Yamaguchi,Takao Hayakawa, Biologicals : journal of the International Association of Biological Standardization, Vol. 32, No. 3, p. 139-46, 2004/09
Simultaneous imaging of initiator/effector caspase activity and mitochondrial membrane potential during cell death in living HeLa cells, Hiroshi Kawai,Takuo Suzuki,Tetsu Kobayashi,Hiroyuki Mizuguchi,Takao Hayakawa,Toru Kawanishi, Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1693, No. 2, p. 101-110, 2004/08/23
Simultaneous imaging of initiator/effector caspase activity and mitochondrial membrane potential during cell death in living HeLa cells., Hiroshi Kawai,Takuo Suzuki,Tetsu Kobayashi,Hiroyuki Mizuguchi,Takao Hayakawa,Toru Kawanishi, Biochimica et biophysica acta, Vol. 1693, No. 2, p. 101-10, 2004/08/23
Adenovirus vector-mediated doxycycline-inducible RNA interference., Tetsuji Hosono,Hiroyuki Mizuguchi,Kazufumi Katayama,Zhi-Li Xu,Fuminori Sakurai,Akiko Ishii-Watabe,Kenji Kawabata,Teruhide Yamaguchi,Shinsaku Nakagawa,Tadanori Mayumi,Takao Hayakawa, Human gene therapy, Vol. 15, No. 8, p. 813-9, 2004/08
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber, J. Q. Gao,S. Inoue,Y. Tsukada,K. Katayama,Y. Eto,S. Kurachi,H. Mizuguchi,T. Hayakawa,Y. Tsutsumi,T. Mayumi,Shinsaku Nakagawa, Pharmazie, Vol. 59, No. 7, p. 571-572, 2004/07
Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA)., Yusuke Eto,Jian-Qing Gao,Fumiko Sekiguchi,Shinnosuke Kurachi,Kazufumi Katayama,Hiroyuki Mizuguchi,Takao Hayakawa,Yasuo Tsutsumi,Tadanori Mayumi,Shinsaku Nakagawa, Biological & pharmaceutical bulletin, Vol. 27, No. 6, p. 936-8, 2004/06
Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy., Naoki Okada,Jian-Qing Gao,Akinori Sasaki,Masakazu Niwa,Yuka Okada,Takashi Nakayama,Osamu Yoshie,Hiroyuki Mizuguchi,Takao Hayakawa,Takuya Fujita,Akira Yamamoto,Yasuo Tsutsumi,Tadanori Mayumi,Shinsaku Nakagawa, Biochemical and biophysical research communications, Vol. 317, No. 1, p. 68-76, 2004/04/23
Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors, J. Q. Gao,L. S. Alexandre,Y. Tsuda,K. Katayama,Y. Eto,F. Sekiguchi,H. Mizuguchi,T. Hayakawa,T. Nakayama,O. Yoshie,Y. Tsutsumi,T. Mayumi,Shinsaku Nakagawa, Pharmazie, Vol. 59, No. 3, p. 238-239, 2004/03
Antibody-targeted cell fusion., Takafumi Nakamura,Kah-Whye Peng,Sompong Vongpunsawad,Mary Harvey,Hiroyuki Mizuguchi,Takao Hayakawa,Roberto Cattaneo,Stephen J Russell, Nature biotechnology, Vol. 22, No. 3, p. 331-6, 2004/03
RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA., Kazufumi Katayama,Koichiro Wada,Hiroyuki Miyoshi,Kozo Ohashi,Masashi Tachibana,Rie Furuki,Hiroyuki Mizuguchi,Takao Hayakawa,Atsushi Nakajima,Takashi Kadowaki,Yasuo Tsutsumi,Shinsaku Nakagawa,Yoshinori Kamisaki,Tadanori Mayumi, FEBS letters, Vol. 560, No. 1-3, p. 178-82, 2004/02/27
Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma., Yuka Okada,Naoki Okada,Hiroyuki Mizuguchi,Koichi Takahashi,Takao Hayakawa,Tadanori Mayumi,Nobuyasu Mizuno, Biochimica et biophysica acta, Vol. 1670, No. 3, p. 172-80, 2004/02/24
Erratum: Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors (Cancer Letters (2002) 177 (57-63)), Yuka Okada,Naoki Okada,Shinsaku Nakagawa,Hiroyuki Mizuguchi,Makiko Kanehira,Naoko Nishino,Koichi Takahashi,Nobuyasu Mizuno,Takao Hayakawa,Tadanori Mayumi, Cancer Letters, Elsevier Ireland Ltd, Vol. 204, No. 1, p. 115-116, 2004/02/10
Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation, Takatoshi Anno,Shunsuke Uehara,Hideki Katagiri,Yasuharu Ohta,Kohei Ueda,Hiroyuki Mizuguchi,Yoshinori Moriyama,Yoshitomo Oka,Yukio Tanizawa, American Journal of Physiology - Endocrinology and Metabolism, Vol. 286, No. 2, p. E280-E285, 2004/02
Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma, Yuka Okada,Naoki Okada,Hiroyuki Mizuguchi,Koichi Takahashi,Takao Hayakawa,Tadanori Mayumi,Nobuyasu Mizuno, Biochim. Biophys. Acta, ELSEVIER SCIENCE BV, Vol. 1670, No. 3, p. 172-180, 2004/02
Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation., Naoya Koizumi,Hiroyuki Mizuguchi,Fuminori Sakurai,Teruhide Yamaguchi,Yoshiteru Watanabe,Takao Hayakawa, Journal of virology, Vol. 77, No. 24, p. 13062-72, 2003/12
Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR., Akiko Ishii-Watabe,Eriko Uchida,Akiko Iwata,Ryuji Nagata,Kouei Satoh,Kejun Fan,Mitsuhiro Murata,Hiroyuki Mizuguchi,Nana Kawasaki,Toru Kawanishi,Teruhide Yamaguchi,Takao Hayakawa, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 8, No. 6, p. 1009-16, 2003/12
Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model., Kunihiko Tanaka,Shinichiro Towata,Kazuhiko Nakao,Hiroyuki Mizuguchi,Takao Hayakawa,Masami Niwa,Nobuko Ishii,Yuji Nagayama, Clinical endocrinology, Vol. 59, No. 6, p. 734-42, 2003/12
Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector., Fuminori Sakurai,Hiroyuki Mizuguchi,Teruhide Yamaguchi,Takao Hayakawa, Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 8, No. 5, p. 813-21, 2003/11
A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells., Akira Itoh,Takashi Okada,Hiroyuki Mizuguchi,Takao Hayakawa,Hiroaki Mizukami,Akihiro Kume,Masaaki Takatoku,Norio Komatsu,Yutaka Hanazono,Keiya Ozawa, The journal of gene medicine, Vol. 5, No. 11, p. 929-40, 2003/11
In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice., Norio Abiru,Fuyan Sun,Eiji Kawasaki,Hironori Yamasaki,Katsuya Oshima,Yuji Nagayama,Hiroyuki Mizuguchi,Takao Hayakawa,Dongmei Miao,Edwin Liu,George S Eisenbarth,Katsumi Eguchi, Annals of the New York Academy of Sciences, Vol. 1005, p. 218-21, 2003/11
Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice, Naoki Okada,Yasushige Masunaga,Yuka Okada,Hiroyuki Mizuguchi,Sayaka Iiyama,Naoki Mori,Akinori Sasaki,Shinsaku Nakagawa,Tadanori Mayumi,Takao Hayakawa,Takuya Fujita,Akira Yamamoto, Gene Ther., NATURE PUBLISHING GROUP, Vol. 10, No. 22, p. 1891-1902, 2003/10
Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions., Hiroyuki Mizuguchi,Zhi-Li Xu,Fuminori Sakurai,Tadanori Mayumi,Takao Hayakawa, Human gene therapy, Vol. 14, No. 13, p. 1265-77, 2003/09/01
[Basic study for next-generation gene therapy products]., Hiroyuki Mizuguchi, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 123, No. 9, p. 761-71, 2003/09
RGDファイバー変異を挿入した腫瘍特異的増殖可能アデノウイルス(TRAD)の抗腫瘍効果の増強, 滝正樹,藤原俊義,川嶋健,岸本浩行,藤原俊哉,水口裕之,京哲,香川俊輔,西崎正彦,田中紀章, 日本癌学会総会記事, (一社)日本癌学会, Vol. 62回, p. 161-161, 2003/08
Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model, Y. Nagayama,K. Nakao,H. Mizuguchi,T. Hayakawa,M. Niwa, Gene Therapy, Vol. 10, No. 16, p. 1400-1403, 2003/08
[Viral vectors for the study of gene function analysis]., Hiroyuki Mizuguchi,Takao Hayakawa, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 48, No. 11 Suppl, p. 1653-62, 2003/08
Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector., Jian-Qing Gao,Yasuhiro Tsuda,Kazufumi Katayama,Takashi Nakayama,Yutaka Hatanaka,Yoichi Tani,Hiroyuki Mizuguchi,Takao Hayakawa,Osamu Yoshie,Yasuo Tsutsumi,Tadanori Mayumi,Shinsaku Nakagawa, Cancer research, Vol. 63, No. 15, p. 4420-5, 2003/08/01
Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors, Zhi-Li Xu,Hiroyuki Mizuguchi,Tadanori Mayumi,Takao Hayakawa, Biochimica et Biophysica Acta - General Subjects, Elsevier, Vol. 1621, No. 3, p. 266-271, 2003/06/11
Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors., Zhi-Li Xu,Hiroyuki Mizuguchi,Tadanori Mayumi,Takao Hayakawa, Biochimica et biophysica acta, Vol. 1621, No. 3, p. 266-71, 2003/06/11
Efficient gene transfer into human CD34(+) cells by an adenovirus type 35 vector, F Sakurai,H Mizuguchi,T Hayakawa, GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 10, No. 12, p. 1041-1048, 2003/06
Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice, Yiwen Li,Genzou Takemura,Ken-ichiro Kosai,Kentaro Yuge,Satoshi Nagano,Masayasu Esaki,Kazuko Goto,Tomoyuki Takahashi,Kenji Hayakawa,Masahiko Koda,Yukinori Kawase,Rumi Maruyama,Hideshi Okada,Shinya Minatoguchi,Hiroyuki Mizuguchi,Takako Fujiwara,Hisayoshi Fujiwara, Circulation, Vol. 107, No. 19, p. 2499-2506, 2003/05/20
Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems., Zhi-Li Xu,Hiroyuki Mizuguchi,Tadanori Mayumi,Takao Hayakawa, Gene, Vol. 309, No. 2, p. 145-51, 2003/05/08
樹状細胞免疫療法の有効性改善を目指したケモカイン発現ベクターの併用, 佐々木明徳,岡田直貴,大久保米起,岡田裕香,中山隆志,義江修,水口裕之,早川尭夫,中川晋作,真弓忠範,藤田卓也,山本昌, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 248-248, 2003/05
IL-12遺伝子を導入した樹状細胞の表現型と腫瘍免疫誘導能の解析, 飯山さやか,岡田直貴,舛永安繁,西田雅也,岡田裕香,水口裕之,早川尭夫,中川晋作,真弓忠範,藤田卓也,山本昌, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 248-248, 2003/05
遺伝子治療の最適化を目指したポリエチレングリコール修飾アデノウイルスベクターの血中滞留性に関する検討, 衛藤佑介,関口文子,高建青,形山和史,堤康央,櫻井文教,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 249-249, 2003/05
改良型アデノウイルスベクターを用いた胎盤への遺伝子導入, 古木理恵,形山和史,立花雅史,大橋興三,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 18, No. 3, p. 250-250, 2003/05
Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors., Naoki Okada,Yasushige Masunaga,Yuka Okada,Sayaka Iiyama,Naoki Mori,Takashi Tsuda,Asako Matsubara,Hiroyuki Mizuguchi,Takao Hayakawa,Takuya Fujita,Akira Yamamoto, Cancer gene therapy, Vol. 10, No. 5, p. 421-31, 2003/05
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model., Kazufumi Katayama,Koichiro Wada,Atsushi Nakajima,Hiroyuki Mizuguchi,Takao Hayakawa,Shinsaku Nakagawa,Takashi Kadowaki,Ryozo Nagai,Yoshinori Kamisaki,Richard S Blumberg,Tadanori Mayumi, Gastroenterology, Vol. 124, No. 5, p. 1315-24, 2003/05
An investigation of adverse effects caused by the injection of high-dose TNF alpha-expressing adenovirus vector into established murine melanoma, Yuka Okada,Naoki Okada,Hiroyuki Mizuguchi,Takao Hayakawa,Tadanori Mayumi,Nobuyasu Mizuno, Gene Ther., NATURE PUBLISHING GROUP, Vol. 10, No. 8, p. 700-705, 2003/04
Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine., Yuji Nagayama,Hiroyuki Mizuguchi,Takao Hayakawa,Masami Niwa,Sandra M McLachlan,Basil Rapoport, Journal of immunology (Baltimore, Md. : 1950), Vol. 170, No. 7, p. 3522-7, 2003/04/01
Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob., Naoya Koizumi,Hiroyuki Mizuguchi,Naoki Utoguchi,Yoshiteru Watanabe,Takao Hayakawa, The journal of gene medicine, Vol. 5, No. 4, p. 267-76, 2003/04
Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells., Atsushi Kita,Shigeo Uotani,Hironaga Kuwahara,Ryoko Takahashi,Katsuya Oshima,Hironori Yamasaki,Hiroyuki Mizuguchi,Takao Hayakawa,Yuji Nagayama,Yoshihiko Yamaguchi,Katsumi Eguchi, Biochemical and biophysical research communications, Vol. 302, No. 4, p. 805-9, 2003/03/21
Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells., Tomoaki Morioka,Hidenori Koyama,Hisako Yamamura,Shinji Tanaka,Shinya Fukumoto,Masanori Emoto,Hiroyuki Mizuguchi,Takao Hayakawa,Itaru Kojima,Katsuhito Takahashi,Yoshiki Nishizawa, Diabetes, Vol. 52, No. 3, p. 760-6, 2003/03
A novel T7 system utilizing mRNA coding for T7 RNA polymerase., Risako Nakano,Tetsuhiko Nakagawa,Susumu Imazu,Kazufumi Katayama,Hiroyuki Mizuguchi,Takao Hayakawa,Yasuo Tsutsumi,Shinsaku Nakagawa,Tadanori Mayumi, Biochemical and biophysical research communications, Vol. 301, No. 4, p. 974-8, 2003/02/21
Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro., Yosei Kawamata,Yuji Nagayama,Kazuhiko Nakao,Hiroyuki Mizuguchi,Takao Hayakawa,Toshinori Sato,Nobuko Ishii, Biomaterials, Vol. 23, No. 23, p. 4573-9, 2002/12
Enhancement of phage-mediated gene transfer by nuclear localization signal., Teruo Akuta,Akiko Eguchi,Hajime Okuyama,Takao Senda,Hachiro Inokuchi,Yosuke Suzuki,Emi Nagoshi,Hiroyuki Mizuguchi,Takao Hayakawa,Katsuo Takeda,Mamoru Hasegawa,Mahito Nakanishi, Biochemical and biophysical research communications, Vol. 297, No. 4, p. 779-86, 2002/10/04
gp100遺伝子を導入したマウス樹状細胞の免疫学的特性と腫瘍免疫誘導効果, 岡田直貴,岡田裕香,水口裕之,早川尭夫,中川晋作,真弓忠範,藤田卓也,山本昌, 日本癌学会総会記事, 日本癌学会, Vol. 61回, p. 461-461, 2002/10
Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells., Eriko Uchida,Hiroyuki Mizuguchi,Akiko Ishii-Watabe,Takao Hayakawa, Biological & pharmaceutical bulletin, Vol. 25, No. 7, p. 891-7, 2002/07
Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line., Nobuhiko Omori,Hiroyuki Mizuguchi,Keiko Ohsawa,Shinichi Kohsaka,Takao Hayakawa,Koji Abe,Futoshi Shibasaki, Neuroscience letters, Vol. 324, No. 2, p. 145-8, 2002/05/17
Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector., Zhi-Li Xu,Hiroyuki Mizuguchi,Akiko Ishii-Watabe,Eriko Uchida,Tadanori Mayumi,Takao Hayakawa, Journal of controlled release : official journal of the Controlled Release Society, Vol. 81, No. 1-2, p. 155-63, 2002/05/17
遺伝子治療の最適化を目指したアデノウイルスベクターのPolyethylene Glycol修飾と遺伝子発現活性, 関口文子,形山和史,林哲,津田育宏,堤康央,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 17, No. 3, p. 293-293, 2002/05
ファイバーミュータントアデノウイルスベクターによりメラノーマ関連抗原遺伝子を導入した樹状細胞の腫瘍免疫誘導効果, 舛永安繁,岡田直貴,斎藤友美,飯山さやか,津田貴司,松原亜沙子,森直樹,水口裕之,早川尭夫,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 17, No. 3, p. 254-254, 2002/05
The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector, Hiroyuki Mizuguchi,Takao Hayakawa, Journal of Gene Medicine, Vol. 4, No. 3, p. 240-247, 2002/05
Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG., Masato Takahashi,Naohiko Seki,Toshinori Ozaki,Masaki Kato,Tomoko Kuno,Takahito Nakagawa,Ken-ichi Watanabe,Koh Miyazaki,Miki Ohira,Shunji Hayashi,Mitsuchika Hosoda,Hisashi Tokita,Hiroyuki Mizuguchi,Takao Hayakawa,Satoru Todo,Akira Nakagawara, Cancer research, Vol. 62, No. 8, p. 2203-9, 2002/04/15
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter., Takahito Nakagawa,Masato Takahashi,Toshinori Ozaki,Ken-ichi Watanabe Ki,Satoru Todo,Hiroyuki Mizuguchi,Takao Hayakawa,Akira Nakagawara, Molecular and cellular biology, Vol. 22, No. 8, p. 2575-85, 2002/04
Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors., Yuka Okada,Naoki Okada,Shinsaku Nakagawa,Hiroyuki Mizuguchi,Koichi Takahashi,Nobuyasu Mizuno,Takuya Fujita,Akira Yamamoto,Takao Hayakawa,Tadanori Mayumi, Japanese journal of cancer research : Gann, Vol. 93, No. 4, p. 436-44, 2002/04
A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor., Yuji Nagayama,Masako Kita-Furuyama,Takao Ando,Kazuhiko Nakao,Hiroyuki Mizuguchi,Takao Hayakawa,Katsumi Eguchi,Masami Niwa, Journal of immunology (Baltimore, Md. : 1950), Vol. 168, No. 6, p. 2789-94, 2002/03/15
Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors., Yuka Okada,Naoki Okada,Shinsaku Nakagawa,Hiroyuki Mizuguchi,Makiko Kanehira,Naoko Nishino,Koichi Takahashi,Nobuyasu Mizuno,Takao Hayakawa,Tadanori Mayumi, Cancer letters, Vol. 177, No. 1, p. 57-63, 2002/03/08
インテグリン指向性ファイバーミュータントアデノウイルスベクターの改良とその評価, 井上暢子,形山和史,堤康央,中川晋作,水口裕之,早川堯夫,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 62, No. Suppl., p. 252-252, 2002/03
Cell Deliveryによる癌治療法の開発新規ケモカインILCのin vivoにおける細胞遊走能評価と癌治療への応用, 津田育宏,形山和史,中山隆志,畑中豊,谷洋一,水口裕之,早川尭夫,中川晋作,義江修,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 62, No. Suppl., p. 141-141, 2002/03
Polyethylene Glycolを用いたバイオコンジュゲート化アデノウイルスベクターの粒子設計, 関口文子,長谷和明,形山和史,林哲,堤康央,中川晋作,水口裕之,早川堯夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 77-77, 2002/03
RGDファイバーミュータントアデノウイルスベクターによるマウス骨髄由来樹状細胞への効率的な遺伝子導入, 舛永安繁,岡田直貴,斎藤友美,飯山さやか,津田貴司,松原亜沙子,森直樹,水口裕之,早川堯夫,中川晋作,真弓忠範,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 79-79, 2002/03
アデノウイルスファイバー領域を提示したファージの構築とそのペプチドライブラリ化, 吉川友章,山本陽子,形山和史,吉岡靖雄,水口裕之,早川堯夫,堤康央,中川晋作,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 80-80, 2002/03
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase., Hiroyuki Mizuguchi,Takao Hayakawa, Cancer gene therapy, Vol. 9, No. 3, p. 236-42, 2002/03
Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes., Hiroyuki Mizuguchi,Takao Hayakawa, Gene, Vol. 285, No. 1-2, p. 69-77, 2002/02/20
Community dynamics of free-living and particle-associated bacterial assemblages during a freshwater phytoplankton bloom (Microbial Ecology 42:(274-285)), H. Mizuguchi,N. Koizumi,T. Hosono,A. Ishii-Watabe,E. Uchida,N. Utoguchi,Y. Watanabe,T. Hayakawa, Microbial Ecology, Vol. 43, No. 2, 2002
CAR-or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice, H. Mizuguchi,N. Koizumi,T. Hosono,A. Ishii-Watabe,E. Uchida,N. Utoguchi,Y. Watanabe,T. Hayakawa, Gene Therapy, Vol. 9, No. 12, p. 769-776, 2002
Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide., N Koizumi,H Mizuguchi,T Hosono,A Ishii-Watabe,E Uchida,N Utoguchi,Y Watanabe,T Hayakawa, Biochimica et biophysica acta, Vol. 1568, No. 1, p. 13-20, 2001/11/07
Characteristics of adenovirus-mediated tetracycline-controllable expression system, H. Mizuguchi,T. Hayakawa, Biochimica et Biophysica Acta - General Subjects, Vol. 1568, No. 1, p. 21-29, 2001/11/07
Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide, N. Koizumi,H. Mizuguchi,T. Hosono,A. Ishii-Watabe,E. Uchida,N. Utoguchi,Y. Watanabe,T. Hayakawa, Biochimica et Biophysica Acta - General Subjects, Vol. 1568, No. 1, p. 13-20, 2001/11/07
Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells, N Okada,T Saito,Y Masunaga,Y Tsukada,S Nakagawa,H Mizuguchi,K Mori,Y Okada,T Fujita,T Hayakawa,T Mayumi,A Yamamoto, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 61, No. 21, p. 7913-7919, 2001/11
Involvement of a calcium-independent pathway in plasmin-induced platelet shape change, A. Ishii-Watabe,E. Uchida,H. Mizuguchi,T. Hayakawa, Life Sciences, Vol. 69, No. 8, p. 945-960, 2001/07/13
Optimization of transcriptional regulatory elements for constructing plasmid vectors, Zhi-Li Xu,Hiroyuki Mizuguchi,Akiko Ishii-Watabe,Eriko Uchida,Tadanori Mayumi,Takao Hayakawa, Gene, Vol. 272, No. 1-2, p. 149-156, 2001/07/11
TNF-α発現ファイバーミュータントアデノウイルスベクターによるマウスメラノーマの遺伝子治療, 岡田裕香,中川晋作,井上暢子,岡田真貴,水口裕之,高橋幸一,水野亘恭,早川尭夫,真弓忠範, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 342-342, 2001/07
ファイバーミュータントアデノウイルスベクターにより抗原遺伝子導入した樹状細胞の免疫学的機能評価, 斎藤友美,岡田直貴,飯山さやか,津田貴司,松原亜沙子,森直樹,水口裕之,早川尭夫,堤康央,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 16, No. 4, p. 307-307, 2001/07
ケモカインを用いた癌免疫療法の基礎的検討, 津田育宏,中川晋作,塚田有希子,水口裕之,早川尭夫,中山隆志,義江修,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 61, No. Suppl., p. 74-74, 2001/03
癌サイトカイン遺伝子治療における次世代型ファイバーミュータントアデノウイルスベクターの有用性, 井上暢子,岡田裕香,中川晋作,岡田直貴,水口裕之,早川尭夫,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 61, No. Suppl., p. 75-75, 2001/03
次世代型アデノウイルスベクターによる樹状細胞への遺伝子導入, 岡田直貴,森宏平,斎藤友美,舛永安繁,藤田淳子,塚田有希子,中川晋作,真弓忠範,水口裕之,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121年会, No. 3, p. 128-128, 2001/03
樹状細胞を用いた癌免疫療法における次世代型アデノウイルスベクターの有用性評価, 塚田有希子,中川晋作,岡田直貴,森宏平,斎藤友美,藤田卓也,山本昌,水口裕之,早川尭夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 121年会, No. 3, p. 128-128, 2001/03
Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors, N Okada,Y Tsukada,S Nakagawa,H Mizuguchi,K Mori,T Saito,T Fujita,A Yamamoto,T Hayakawa,T Mayumi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 282, No. 1, p. 173-179, 2001/03
Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system, Yuji Nagayama,Eijun Nishihara,Hiroyuki Namba,Haruhiko Yokoi,Mamoru Hasegawa,Hiroyuki Mizuguchi,Takao Hayakawa,Hirofumi Hamada,Shunichi Yamashita,Masami Niwa, Cancer Gene Therapy, Nature Publishing Group, Vol. 8, No. 1, p. 36-44, 2001
In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors, Hiroyuki Mizuguchi,Mark A. Kay,Takao Hayakawa, BioTechniques, Vol. 30, No. 5, p. 1112-1116, 2001
A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob, H. Mizuguchi,N. Koizumi,T. Hosono,N. Utoguchi,Y. Watanabe,M. A. Kay,T. Hayakawa, Gene Therapy, Vol. 8, No. 9, p. 730-735, 2001
樹状細胞への効率的な遺伝子導入を目指したアデノウイルスベクターの開発, 塚田有希子,中川晋作,岡田直貴,森宏平,斎藤友美,藤田卓也,山本晶,水口裕之,早川尭夫,真弓忠範, 日本バイオマテリアル学会大会予稿集, 日本バイオマテリアル学会, Vol. シンポジウム2000, p. 186-186, 2000/11
A novel nonviral vector based on vesicular stomatitis virus, Susumu Imazu,Shinsaku Nakagawa,Tsuyoshi Nakanishi,Hiroyuki Mizuguchi,Hidetoshi Uemura,Osamu Yamada,Tadanori Mayumi, Journal of Controlled Release, Vol. 68, No. 2, p. 187-194, 2000/08/10
On the mechanism of plasmin-induced platelet aggregation: Implications of the dual role of granule ADP, Akiko Ishii-Watabe,Eriko Uchida,Hiroyuki Mizuguchi,Takao Hayakawa, Biochemical Pharmacology, Vol. 59, No. 11, p. 1345-1355, 2000/06/01
Long-term replication of Epstein-Barr virus-derived episomal vectors in the rodent cells, Hiroyuki Mizuguchi,Tetsuji Hosono,Takao Hayakawa, FEBS Letters, Vol. 472, No. 2-3, p. 173-178, 2000/04/28
IRES-Dependent Second Gene Expression Is Significantly Lower Than Cap-Dependent First Gene Expression in a Bicistronic Vector, Hiroyuki Mizuguchi,Zhili Xu,Akiko Ishii-Watabe,Eriko Uchida,Takao Hayakawa, Molecular Therapy, Vol. 1, No. 4, p. 376-382, 2000/04
A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors, Hiroyuki Mizuguchi,Mark A. Kay, Human Gene Therapy, Vol. 10, No. 12, p. 2013-2017, 1999/08/10
β-globin sequenceの付加に伴うT7細胞質内遺伝子発現系の改善, 中野里佐子,中川哲彦,水口裕之,形山和史,堤康央,久保一義,中川晋作,早川尭夫,中西真人,真弓忠範, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 59, No. Suppl., p. 108-108, 1999/03
mRNAを利用した新規細胞質内遺伝子発現系の開発, 中野里佐子,中川哲彦,形山和史,堤康央,久保一義,中川晋作,真弓忠範,中西真人,水口裕之,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 17-17, 1999/03
Target-cell specificity of fusogenic liposomes: membrane fusion-mediated macromolecule delivery into human blood mononuclear cells., A Watabe,T Yamaguchi,T Kawanishi,E Uchida,A Eguchi,H Mizuguchi,T Mayumi,M Nakanishi,T Hayakawa, Biochimica et biophysica acta, Vol. 1416, No. 1-2, p. 339-48, 1999/01/12
Target-cell specificity of fusogenic liposomes: Membrane fusion-mediated macromolecule delivery into human blood mononuclear cells, Akiko Watabe,Teruhide Yamaguchi,Toru Kawanishi,Eriko Uchida,Akiko Eguchi,Hiroyuki Mizuguchi,Tadanori Mayumi,Mahito Nakanishi,Takao Hayakawa, Biochimica et Biophysica Acta - Biomembranes, Vol. 1416, No. 1-2, p. 339-348, 1999/01/12
Gene delivery systems using the Sendai virus, Mahito Nakanishi,Hiroyuki Mizuguchi,Ken-Ichi Ashihara,Takao Senda,Akiko Eguchi,Akiko Watabe,Tsuyoshi Nakanishi,Masuo Kondo,Tetsuhiko Nakagawa,Akinori Masago,Jun Okabe,Shigeharu Ueda,Tadanori Mayumi,Takao Hayakawa, Molecular Membrane Biology, Taylor and Francis Ltd, Vol. 16, No. 1, p. 123-127, 1999
Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method, Hiroyuki Mizuguchi,Mark A. Kay, Human Gene Therapy, Vol. 9, No. 17, p. 2577-2583, 1998/11/20
Preparation of unilamellar fusogenic liposomes using the Sendai virus, Mahito Nakanishi,Hiroyuki Mizuguchi, Folia Pharmacologica Japonica, Japanese Pharmacological Society, Vol. 112, No. 5, p. 299-305, 1998
Preparation of glial extracellular matrix: A novel method to analyze glial-endothelial cell interaction, Hiroyuki Mizuguchi,Naoki Utoguchi,Tadanori Mayumi, Brain Research Protocols, Vol. 1, No. 4, p. 339-343, 1997/10
Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain, Hiroyuki Mizuguchi,Tetsuhiko Nakagawa,Yuka Morioka,Susumu Imazu,Mahito Nakanishi,Toru Kondo,Takao Hayakawa,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 234, No. 1, p. 15-18, 1997/05/08
膜融合リポソーム効率のよい細胞質内への物質導入ベクター, 水口裕之,中川晋作,真弓忠範, 医学のあゆみ, 医歯薬出版(株), Vol. 180, No. 11, p. 718-719, 1997/03
Cytomedical therapy for IgG1 plasmacytosis in human interleukin-6 transgenic mice using hybridoma cells microencapsulated in alginate-poly(L)lysine-alginate membrane, Naoki Okada,Hajime Miyamoto,Tatsunobu Yoshioka,Asao Katsume,Hiroyuki Saito,Keigo Yorozu,Otoya Ueda,Norio Itoh,Hiroyuki Mizuguchi,Shinsaku Nakagawa,Yoshiyuki Ohsugi,Tadanori Mayumi, Biochim. Biophys. Acta, ELSEVIER SCIENCE BV, Vol. 1360, No. 1, p. 53-63, 1997/02
遺伝子治療,そして細胞性製剤への道, 水口裕之,中川晋作,中西真人, ファルマシア, (公社)日本薬学会, Vol. 32, No. 12, p. 1495-1500, 1996/12
固形癌遺伝子治療に対する新しい戦略腫瘍支配動脈内へのTNF-α遺伝子導入による抗腫瘍効果の誘導, 中川哲彦,水口裕之,今津進,森岡裕香,中川晋作,真弓忠範,中西真人, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 116年会, No. 4, p. 78-78, 1996/03
Efficient gene transfer into mammalian cells using fusogenic liposome, Hiroyuki Mizuguchi,Tetsuhiko Nakagawa,Mahito Nakanishi,Susumu Imazu,Shinsaku Nakagawa,Tadanori Mayumi, Biochemical and Biophysical Research Communications, Academic Press Inc., Vol. 218, No. 1, p. 402-407, 1996/01/05
Effects of Rat Hepatocytes on Macromolecular Permeability of Bovine Aortic Endothelial Cell Monolayer, N. Utoguchi,H. Mizuguchi,K. Saeki,K. Ikeda,S. Nakagawa,Tadanori Mayumi, International Journal of Microcirculation-Clinical and Experimental, Vol. 16, No. 2, p. 105-110, 1996/01/01
Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy, H. Mizuguchi,M. Nakanishi,T. Nakanishi,T. Nakagawa,S. Nakagawa,T. Mayumi, British Journal of Cancer, Nature Publishing Group, Vol. 73, No. 4, p. 472-476, 1996
Effect of tumour cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen, N. Utoguchi,H. Mizuguchi,A. Dantakean,H. Makimoto,Y. Wakai,Y. Tsutsumi,S. Nakagawa,T. Mayumi, British Journal of Cancer, Nature Publishing Group, Vol. 73, No. 1, p. 24-28, 1996
TUMOR-CONDITIONED MEDIUM INCREASES MACROMOLECULAR PERMEABILITY OF ENDOTHELIAL-CELL MONOLAYER, N UTOGUCHI,H MIZUGUCHI,K SAEKI,K IKEDA,Y TSUTSUMI,S NAKAGAWA,T MAYUMI, CANCER LETTERS, ELSEVIER SCI PUBL IRELAND LTD, Vol. 89, No. 1, p. 7-14, 1995/02
Efficient gene transfer using unilamellar fusogenic liposomes, Hiroyuki Mizuguchi,Eken-ichi Ashihara,Tadanori Mayumi,Takao Senda,Mahito Nakanishi, Drug Delivery System, Vol. 9, No. 2, p. 81-87, 1994

Misc.

Polydimethylsiloxane製liver-on-a-chipを用いた薬物代謝・毒性試験, 出口清香,津田真弘,小杉香織,水口裕之,山下富義,鳥澤勇介,高山和雄, The Journal of Toxicological Sciences, (一社)日本毒性学会, Vol. 46, No. Suppl., p. S107-S107, 2021/07
Polydimethylsiloxane製のliver-on-a-chipの薬物動態研究への応用, 出口清香,津田真弘,小杉香織,前田和哉,楠原洋之,水口裕之,山下富義,鳥澤勇介,高山和雄, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 141年会, p. 27V09-pm08S, 2021/03
レオウイルス感染がん細胞由来細胞外小胞のがん細胞に対する殺細胞効果の検討, 櫻井文教,井上智重子,種昂なお実,神宮司健太郎,神宮司健太郎,辻川和丈,辻川和丈,水口裕之,水口裕之,水口裕之,水口裕之,水口裕之, 日本DDS学会学術集会プログラム予稿集, Vol. 37th, 2021
ヒトiPS細胞技術を用いた常染色体劣性高コレステロール血症の病態再現, 冨田純矢,高山和雄,堀美香,斯波真理子,水口裕之, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 140年会, p. 26G-pm16S, 2020/03
Establishment of a CYP3A4-mediated drug evaluation system using human iPS cells and genome editing technology, 出口清香,出口清香,新谷友啓,池野喬之,花岡健二郎,浦野泰照,浦野泰照,浦野泰照,竹村晃典,伊藤晃成,高山和雄,高山和雄,高山和雄,高山和雄,水口裕之,水口裕之,水口裕之,水口裕之,水口裕之, 日本薬学会年会要旨集(CD-ROM), Vol. 140年会, p. 28Y-pm13S, 2020/03
ALK阻害剤既治療例のALK融合遺伝子変異陽性肺扁平上皮癌にセリチニブが長期奏効した1例, 本村宏明,渡邊純子,十合晋作,佐々木信一,高橋和久,林大久生,植草利公,浦田泰生,水口裕之,加藤俊介, 肺癌, (NPO)日本肺癌学会, Vol. 58, No. 2, p. 162-163, 2018/04
Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector, Masahisa Hemmi,Masashi Tachibana,Natsuki Fujimoto,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 100, p. 150-150, 2017/12
Adenovirus Vector-Induced Hepatotoxicity During the Early Phase of Adenoviral Treatment Is Attributed to Inflammatory Cytokine-Induced Leaky Expression of Adenovirus Genes, Kahori Shimizu,Sakurai Fuminori,Shunsuke Iizuka,Masashi Tachibana,Toru Nishinaka,Tomoyuki Terada,Hiroyuki Mizuguchi, MOLECULAR THERAPY, CELL PRESS, Vol. 25, No. 5, p. 264-265, 2017/05
Study of zinc finger AN1-type domain gene transduction by a novel adenovirus vector with lower hepatotoxicity for treatment of diabetes mellitus, K. Shimizu,Y. Ogiya,T. Nishinaka,F. Sakurai,H. Mizuguchi,K. Tomita,T. Terada, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A179-A179, 2016/11
Reovirus-mediated efficient killing of cancer-associated fibroblasts, F. Sakurai,T. Kaminade,M. Tachibana,H. Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A86-A86, 2016/11
Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic administration of an adenovirus vector vaccine, M. Hemmi,M. Tachibana,N. Fujimoto,M. Shoji,F. Sakurai,K. Kobiyama,K. J. Ishii,S. Akira,H. Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A146-A146, 2016/11
Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing, K. Wakabayashi,M. Machitani,M. Tachibana,F. Sakurai,H. Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A174-A174, 2016/11
Elucidation of mechanism of reovirus-mediated down-regulation of hypoxia-inducible factor-1 alpha following reovirus infection, T. Hotani,M. Tachibana,H. Mizuguchi,F. Sakurai, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A90-A90, 2016/11
Effects of antibodies against adenoviral capsid proteins on adenovirus vector-mediated in vivo transduction, K. Tomita,F. Sakurai,M. Machitani,M. Tachibana,H. Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT, INC, Vol. 27, No. 11, p. A148-A148, 2016/11
NASH/NAFLDにおける肝microRNa-27bの臓器移行を介した肥満形成メカニズム, 結束貴臣,本多靖,小川祐二,留野渉,今城健人,馬渡弘典,藤田浩司,米田正人,斉藤聡,中島淳,酒井英子,水口裕之,和田孝一郎, アルコールと医学生物学, (株)響文社, Vol. 34, p. 94-95, 2016/06
Generation of human iPS cell-derived enterocytes for drug discovery, Vol. 74, No. 6, p. 476-481, 2016
再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製, 高山和雄,萩原康子,関口清俊,森尾友宏,小原收,立花雅史,櫻井文教,水口裕之, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, Vol. 88回・38回, p. [1P0999]-[1P0999], 2015/12
Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2, Kazuo Imagawa,Kazuo Takayama,Shigemi Isoyama,Ken Tanikawa,Masato Shinkai,Masayoshi Kage,Kenji Kawabata,Ryo Sumazaki,Hiroyuki Mizuguchi, HEPATOLOGY, WILEY-BLACKWELL, Vol. 62, p. 1032A-1033A, 2015/10
Efficient Transduction in Neonatal Mice via Systemic Administration of an Adenovirus Vector, Shunsuke Iizuka,Fuminori Sakurai,Kahori Shimizu,Masashi Tachibana,Kazuo Ohashi,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 23, p. S46-S46, 2015/05
A novel photodynamic therapy with virus-mediated delivery of photosensitive cytotoxic fluorescent protein KillerRed for human cancers, Kiyoto Takehara,Hiroshi Tazawa,Yuuri Hashimoto,Hiroyuki Kishimoto,Toshiyoshi Fujiwara,Nobuhiro Narii,Hiroyuki Mizuguchi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 74, No. 19, 2014/10
SOCS1 GENE DELIVERY, IN COMBINATION WITH PEMETREXED AND CISPLATIN TREATMENT, ENHANCES THERAPEUTIC EFFICACY IN MALIGNANT MESOTHELIOMA, Kota Iwahori,Satoshi Serada,Minoru Fujimoto,Hiroyuki Mizuguchi,Tetsuji Naka, JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Vol. 16, No. 7-8, p. 276-277, 2014/07
Apoptosis-Resistant and Highly Functional Islet Cell Sheets for Transplantation., H. Hanayama,K. Ohashi,R. Utoh,K. Ise,T. Shimizu,M. Yamato,H. Mizuguchi,F. Sakurai,T. Okano,M. Gotoh, TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 98, p. 332-332, 2014/07
DEVELOPMENT OF AN ADENOVIRUS VECTOR LACKING THE VIRUS-ASSOCIATED RNA EXPRESSION, Mitsuhiro Machitani,Kazufumi Katayama,Fuminori Sakurai,Hayato Matsui,Tomoko Yamaguchi,Takayuki Suzuki,Hiroyuki Miyoshi,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Vol. 16, No. 7-8, p. 234-235, 2014/07
Trichostatin A sensitizes apoptosis induced by soluble TRAIL-expressing MSCs, Ryosuke Uchibori,Hiroyuki Mizuguchi,Tomonori Tsukahara,Masashi Urabe,Hiroaki Mizukami,Akihiro Kume,Keiya Ozawa, JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, Vol. 16, No. 7-8, p. 237-237, 2014/07
Apoptosis-Resistant and Highly Functional Islet Cell Sheets for Transplantation, H. Hanayama,K. Ohashi,R. Utoh,K. Ise,T. Shimizu,M. Yamato,H. Mizuguchi,F. Sakurai,T. Okano,M. Gotoh, AMERICAN JOURNAL OF TRANSPLANTATION, WILEY-BLACKWELL, Vol. 14, p. 332-332, 2014/06
Cathepsin Activity Levels in Tumor Cells Are a Crucial Determinant for Reovirus Oncolysis, Fuminori Sakurai,Yuichi Terasawa,Masashi Tachibana,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 22, p. S252-S253, 2014/05
Oncolytic Reovirus Induces Reduction in Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice, Yuki Katayama,Fuminori Sakurai,Yukako Oya,Yuichi Terasawa,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 22, p. S252-S252, 2014/05
Evaluation of Involvement of microRNA Processing Factors in Adenovirus Replication, Mitsuhiro Machitani,Fuminori Sakurai,Keisaku Wakabayashi,Masashi Tachibana,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 22, p. S32-S32, 2014/05
Type I IFN Signaling Induced By Systemically Administrated Adenovirus Vector Promotes the Antigen-Specific Mucosal Immunity, Masahisa Henmi,Masashi Tachibana,Sayaka Tsuzuki,Masaki Shoji,Fuminori Sakurai,Koji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 22, p. S272-S272, 2014/05
Detection of circulating tumor cells with epithelial-mesenchymal transition phenotype as critical surrogate biomarkers in patients with non-small cell lung cancer, Shinsaku Togo,Kazuya Takamochi,Shiaki Oh,Masaaki Ouchi,Nobuyoshi Katagiri,Yasuo Urata,Fuminori Sakurai,Hiroyuki Mizuguchi,Kenji Suzuki,Kazuhisa Takahashi, JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 32, No. 15, 2014/05
A Self-Reinforcing Pathway of Protective Mucosal Immunity Mediated by Epithelial CD1d, Torsten Olszak,Joana F. Neves,Marie C. Dowds,Kristi Baker,Jonathan Glickman,Nicholas Davidson,Christian Jobin,Stephan Brand,Werner Muller,Koichiro Wada,Kazufumi Katayama,Atsushi Nakajima,Hiroyuki Mizuguchi,Kunito Kawasaki,Kazuhiro Nagata,Stefan Schreiber,Arthur Kaser,Sebastian Zeissig,Richard S. Blumberg, GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 146, No. 5, p. S87-S87, 2014/05
MICRO RNA-27B CAUSES NONALCOHOLIC STEATOHEPATITIS SIMILAR TO HUMAN PATHOPHYSIOLOGY IN MURINE HIGH-FAT DIET MODEL, T. Kessoku,E. Sakai,Y. Honda,Y. Ogawa,W. Tomeno,K. Imajo,H. Mawatari,M. Yoneda,H. Kirikoshi,S. Saito,S. Maeda,Y. Eguchi,H. Mizuguchi,K. Wada,A. Nakajima, JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, Vol. 60, No. 1, p. S155-S155, 2014/04
Suppression of the Leaky Expression of Adenovirus Genes Following Transduction with a Replication-Incompetent Adenovirus Vector by Incorporating microRNA-Targeted Sequences into the 3 '-Untranslated Region of the E2A, E4, or pIX Gene, Kahori Shimizu,Fuminori Sakurai,Shin-ichiro Nakamura,Yasuhito Nagamoto,Kyoko Tomita,Masashi Tachibana,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 21, p. S186-S186, 2013/06
Cytotoxic effect of photosensitive fluorescent protein KillerRed-expressing adenovirus against human cancer cells, Kiyoto Takehara,Hiroshi Tazawa,Yuuri Hashimoto,Hiroyuki Kishimoto,Nobuhiro Narii,Hiroyuki Mizuguchi,Toshiyoshi Fujiwara, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 73, No. 8, 2013/04
WS-17-7 テロメラーゼ活性を指標とする血中遊離癌細胞の高感度検出法の開発と遺伝子解析技術への応用(WS ワークショップ,第113回日本外科学会定期学術集会), 重安邦俊,橋本悠里,宇野太,永坂岳司,田澤大2),香川俊輔,水口裕之,浦田泰生,藤原俊義, 日本外科学会雑誌, 一般社団法人日本外科学会, Vol. 114, No. 2, p. 338-338, 2013/03/05
次世代型制限増殖アデノウイルスを利用した血中循環癌細胞検出法の開発, 櫻井文教,藤原俊義,水口裕之, 薬学雑誌, Vol. 133, p. 291-296, 2013
Efficient Generation of Hepatocyte-like Cells from Human ES/iPS Cells for Drug Toxicity Screening, Vol. 68, No. 1, p. 141-144, 2013/01
Evaluation of Drug Toxicity by Using Hepatocytes Derived from Human iPS Cells, Bio industry, Vol. 30, No. 1, p. 19-24, 2013/01
Type-I IFN Signaling Is Required for the Induction of Antigen-Specific CD8+T Cell Responses by Adenovirus Vector Vaccine in the Gut-Mucosal Compartment, Masashi Tachibana,Masaki Shoji,Kazufumi Katayama,Kyoko Tomita,Sayaka Tsuzuki,Fuminori Sakurai,Kenji Kawabata,Shizuo Akira,Ken J. Ishii,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 20, p. S257-S257, 2012/05
Development of a Novel Targeted Adenovirus Vector Displaying Monobody Binding to Anti-Vascular Endothelial Growth Factor Receptor 2 in a Fiber Protein, Hayato Matsui,Fuminori Sakurai,Masashi Tachibana,Shinnosuke Kurachi,Kazufumi Katayama,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 20, p. S149-S149, 2012/05
Development of a Novel Adenovirus Vector Carrying microRNA-Targeted Sequences in the 3 '-Untranslated Region of the pIX, E2A, or E4 Gene for Suppression of the Leaky Expression of Adenovirus Genes, Kahori Shimizu,Fuminori Sakurai,Masashi Tachibana,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 20, p. S149-S149, 2012/05
Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection, Seiji Yamane,Takeshi Yoshida,Kazuo Takayama,Masuo Kondoh,Fuminori Sakurai,Hiroyuki Mizuguchi,Kiyohito Yagi, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 26, 2012/04
Preclinical evaluation of cytotoxic effect of photosensitive fluorescent protein in human cancer cells, Hiroshi Tazawa,Tsuyoshi Sasaki,Yuuri Hashimoto,Satoru Kikuchi,Hiroyuki Kishimoto,Hiroyuki Mizuguchi,Toshiyoshi Fujiwara, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, 2012/04
A highly sensitive detection system of genetic alterations in circulating tumor cells using a telomerase-specific replication-competent adenovirus, Kunitoshi Shigeyasu,Yuuri Hashimoto,Tatsuya Morikawa,Yoshiko Mori,Dong-Sheng Sun,Shunsuke Kagawa,Futoshi Uno,Hiroshi Tazawa,Takeshi Nagasaka,Satoru Kyo,Hiroyuki Mizuguchi,Yasuo Urata,Toshiyoshi Fujiwara, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, 2012/04
Current Status of Hepatic Differentiation from Human iPS cells and Application of Drug Development, Vol. 43, No. 11, p. 982-987, 2012
In vitro evaluation of the embryotoxic potency of amorphous nanosilica, T. Ogura,Y. Yoshioka,K. Yamashita,K. Kawabata,H. Mizuguchi,T. Yoshikawa,N. Itoh,Y. Tsutsumi, TOXICOLOGY LETTERS, ELSEVIER IRELAND LTD, Vol. 205, p. S251-S251, 2011/08
ヒト胚性幹細胞、人工多能性幹細胞、間葉系幹細胞の細胞特性比較解析, 平田みつひ,林田みどり,館山大揮,小澤裕,松村紘子,家村将士,Shandar Ahmad,正札智子,金村米博,小原有弘,川端健二,水口賢司,水口裕之,古江美保, 組織培養研究, 日本組織培養学会, Vol. 30, No. 1, p. 49-49, 2011/03
DEVELOPMENT OF NEW ADENOVIRAL GENE THERAPY TARGETING HEMATOLOGICAL MALIGNANCIES, Yosuke Yokota,Mayumi Yamamoto,Masaharu Nakayama,Hiroyuki Inoue,Koichi Takayama,Toshiyoshi Fujiwara,Hiroyuki Mizuguchi,David T. Curiel,Kenzaburo Tani, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 12, No. 12, p. 1030-1030, 2010/12
TELOMERASE-SPECIFIC ONCOLYTIC ADENOVIRUS ARMED WITH WILD-TYPE P53 GENE (CGCT-04) EFFICIENTLY INDUCES APOPTOSIS IN HUMAN CANCER CELLS, Yasumoto Yamasaki,Hideki Onimatsu,Yuuri Hashimoto,Toru Kojima,Hiroshi Tazawa,Shunsuke Kagawa,Hiroyuki Mizuguchi,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 12, No. 12, p. 1035-1035, 2010/12
DEVELOPMENT OF FIBER-SUBSTITUTED ADENOVIRUS VECTORS CONTAINING FOREIGN PEPTIDES IN THE ADENOVIRUS SEROTYPE 35 FIBER KNOB, Hayato Matsui,Fuminori Sakurai,Shinnosuke Kurachi,Katsuhisa Tashiro,Kumiko Sugio,Kenji Kawabata,Koichi Yamanishi,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 12, No. 12, p. 1039-1039, 2010/12
MECHANISMS OF MSC (MESENCHYMAL STEM/STROMAL CELL) ACCUMULATION AT TUMOR SITES, Ryosuke Uchibori,Hiroyuki Mizuguchi,Masashi Urabe,Hiroaki Mizukami,Akihiro Kume,Keiya Ozawa, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 12, No. 12, p. 1059-1059, 2010/12
Development of next-generation of adenovirus vectors : the 10th Nagai Award in the 26th Annual Meeting of the Japan Society of Drug Delivery System, MIZUGUCHI Hiroyuki, Drug delivery system, Vol. 25, No. 5, p. 493-503, 2010/10/06
GENE DELIVERY OF SUPPRESSOR OF CYTOKINE SIGNALING 3 (SOCS-3) INDUCES A POTENT ANTITUMOR EFFECT IN MALIGNANT PLEURAL MESOTHELIOMA, K. Shimada,K. Iwahori,S. Serada,M. Fujimoto,H. Mizuguchi,T. Takahashi,T. Naka, ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, Vol. 21, p. 160-160, 2010/10
MIRNA-REGULATED EXPRESSION OF HERPES SIMPLEX VIRUS THYMIDINE KINASE PREVENTS HEPATOTOXICITY WITHOUT DISTURBING ANTITUMOR EFFECT IN ADENOVIRUS VECTOR-MEDIATED SUICIDE GENE THERAPY, Fuminori Sakurai,Takayuki Suzuki,Shin-ichiro Nakamura,Emi Kouyama,Masao Kondoh,Kiyohito Yagi,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 11, No. 12, p. 1153-1154, 2009/12
Recombinant virus for gene therapy and vaccine, MIZUGUCHI Hiroyuki, Vol. 24, No. 6, p. 569-569, 2009/11/16
TLR-independent signaling pathway in the production of IFN-b by replication-incompetent adenovirus vectors, Tomoko Yamaguchi,Kenji Kawabata,Ken Ishii,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT INC, Vol. 20, No. 11, p. 1476-1476, 2009/11
悪性血液腫瘍を標的とした新規キメラ型アデノウイルス遺伝子療法の開発, 横田洋介,山本真由美,中山雅晴,井上博之,高山浩一,藤原俊義,水口裕之,キュリエルデビッド,谷憲三朗, 臨床血液, Vol. 50, No. 9, p. 1114-1114, 2009/09
Analysis of Microtubule-Dependent Transport in Lipid-Encapsulated DNA Nano-Carrier by Real-Time Imaging: Comparison with Adenovirus, Kaoru Enoto,Hidetaka Akita,Tomoya Masuda,Hiroyuki Mizuguchi,Hideyoshi Harashima, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 17, p. S51-S51, 2009/05
Roles of Inflammatory Cytokines in Tumor Tropism of Mesenchymal Stromal Cells, Ryosuke Uchibori,Takayuki Ito,Hiroyuki Mizuguchi,Masashi Urabe,Hiroaki Mizukami,Akihiro Kume,Keiya Ozawa, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 17, p. S108-S108, 2009/05
Telomerase-specific oncolytic adenovirus armed with wild-type p53 gene (CGCT-04) efficiently induces apoptosis in human cancer cells, Yasumoto Yamasaki,Hideki Onimatsu,Yuuri Hashimoto,Toru Kojima,Hiroshi Tazawa,Shunsuke Kagawa,Hiroyuki Mizuguchi,Yasuo Urata,Noriaki Tanaka,Toshiyoshi Fujiwara, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 69, 2009/05
Adenovirus Vector-Mediated Differentiation into Adipocytic and Osteoblastic Lineages from Mouse Induced Pluripotent Stem (iPS) Cells, Kenji Kawabata,Katsuhisa Tashiro,Mitsuru Inamura,Fuminori Sakurai,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 17, p. S263-S263, 2009/05
TLR-Independent Signaling Pathway in IFN-beta Production by Replication-Incompetent Adenovirus Vectors, Tomoko Yamaguchi,Kenji Kawabata,Ken Ishii,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 17, p. S244-S244, 2009/05
遺伝子工学的手法を用いた神経幹細胞から膵β細胞への分化誘導, 林香織,金川尚子,向洋平,吉岡靖雄,吉岡靖雄,水口裕之,岡田直貴,中川晋作,中川晋作, 再生医療, Vol. 8, 2009
Development of recombinant viruses containing microRNA-regulated gene expression system, Fuminori Sakurai,Kenji Kawabata,Hiroyuki Mizuguchi, Drug Delivery System, Vol. 24, No. 6, p. 572-581, 2009
標的指向能を有するバイオコンジュゲート化アデノウイルスベクターの開発, 衛藤佑介,吉岡靖雄,Asavatanabodee Ratima,水口裕之,向洋平,岡田直貴,中川晋作, 薬学雑誌, (公社)日本薬学会, Vol. 128, No. 12, p. 1733-1742, 2008/12
Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency, T. Yoshikawa,T. Niwa,H. Mizuguchi,N. Okada,S. Nakagawa, Gene Therapy, Vol. 15, No. 19, p. 1321-1329, 2008/07/18
Enhancement of human monocyte-derived dendritic cell functions by adenovirus-mediated RNA interference of STAT-3, Tomoko Iwata,Hidetoshi Sumimoto,Hiroyuki Mizuguchi,Yutaka Kawakami, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 10, No. 4, p. 457-457, 2008/04
Intravenous delivery of adenovirus serotype 35 vectors in nonhuman primates, Fuminori Sakurai,Kimiyo Akitomo,Shin-Ichiro Nakamura,Hiroaki Shibata,Keiji Terao,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 10, No. 4, p. 452-452, 2008/04
Adenovirus vectors stimulate innate immunity via MYD88/TLR9-dependent and-independent pathways, Tomoko Yamaguchi,Kenji Kawabata,Naoya Koizumi,Fuminori Sakurai,Kazuko Nakashima,Tomomi Sasaki,Naoki Okada,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 10, No. 4, p. 453-454, 2008/04
Molecular cloning and functional analysis of car-like soluble protein (CLSP), Kenji Kawabata,Fummori Sakurai,Katsuhisa Tashiro,Naoki Osada,Jun Kusuda,Takao Hayakawa,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 10, No. 4, p. 468-469, 2008/04
Suppressor of Cytokine Signaling‐1(SOCS1)を用いたアデノウイルスベクター誘発自然免疫応答回避の試み, 桜井晴奈,田代克久,川端健二,山口朋子,櫻井文教,中川晋作,水口裕之, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 128th, No. 4, p. 106-106, 2008/03/05
転移癌遺伝子治療における全身投与型腫瘍標的化アデノウイルスベクターの有用性評価, 姚醒蕾,吉岡靖雄,吉岡靖雄,衛藤佑介,森重智弘,水口裕之,水口裕之,向洋平,岡田直貴,中川晋作,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 8th, 2008
各種細胞膜移行ペプチドにより修飾したアデノウイルスベクターの遺伝子導入特性評価, ASAVATANABODEE Ratima,吉岡靖雄,吉岡靖雄,衛藤佑介,喜田進也,前田光子,水口裕之,水口裕之,向洋平,岡田直貴,川崎紘一,中川晋作,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 4, 2008
標的指向能を有するバイオコンジュゲート化アデノウイルスベクターの開発, 衛藤佑介,吉岡靖雄,吉岡靖雄,ASAVATANABODEE Ratima,水口裕之,水口裕之,向洋平,岡田直貴,中川晋作,中川晋作, 日本薬学会年会要旨集, Vol. 128th, No. 1, 2008
フラクタルカインを発現する間葉系幹細胞の気管内デリバリーは肺転移を抑制する(Intra-tracheal Delivery of Mesenchymal Stem Cells Expressing Fractalkine Inhibits Lung Metastases), 辛紅,兼平雅彦,カッチヤ・アハマド,孫若文,水口裕之,早川堯夫,貫和敏博,西條康夫, 日本癌学会総会記事, 日本癌学会, Vol. 66回, p. 197-197, 2007/08
Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity, S. Kurachi,K. Tashiro,F. Sakurai,H. Sakurai,K. Kawabata,K. Yayama,H. Okamoto,S. Nakagawa,H. Mizuguchi, GENE THERAPY, NATURE PUBLISHING GROUP, Vol. 14, No. 15, p. 1160-1165, 2007/08
肺がん転移モデルにおけるNK4発現骨髄由来間葉系幹細胞(NK 4-MSCs)を用いた抗腫瘍効果の検討, 兼平雅彦,辛紅,前門戸任,水口裕之,早川尭夫,松本邦夫,中村敏一,貫和敏博,西條康夫, 日本呼吸器学会雑誌, (一社)日本呼吸器学会, Vol. 45, No. 増刊, p. 159-159, 2007/04
Development of improved adenovirus vectors for gene function analysis and gene therapy, MIZUGUCHI HIROYUKI, Vol. 26, No. 1, p. 25-25, 2007/03/31
アデノウイルスベクター誘発自然免疫応答に関与する因子のDNA microarrayを用いた探索, 桜井晴奈,五十嵐勝秀,田代克久,川端健二,櫻井文教,倉知慎之輔,中川晋作,菅野純,水口裕之, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127th, No. 3, p. 87-87, 2007/03/05
Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction, Chiaki Ebihara,Masuo Kondoh,Motoki Harada,Makiko Fujii,Hiroyuki Mizuguchi,Shin-ichi Tsunoda,Yasuhiko Horiguchi,Kiyohito Yagi,Yoshiteru Watanabe, BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 73, No. 6, p. 824-830, 2007/03
腫瘍での遺伝子発現増強と肝臓への集積性・遺伝子発現抑制を充たし得るPEG修飾アデノウイルスベクターの創製, 森重智弘,吉岡靖雄,吉岡靖雄,衛藤佑介,倉知慎之輔,姚醒蕾,水口裕之,水口裕之,向洋平,岡田直貴,中川晋作,中川晋作, Drug Delivery System, Vol. 22, No. 3, 2007
TATペプチドを付与したファイバーミュータントAdベクターの開発と遺伝子発現評価, 倉知慎之輔,倉知慎之輔,桜井晴奈,桜井晴奈,田代克久,田代克久,櫻井文教,川端健二,屋山勝俊,岡本博,中川晋作,水口裕之,水口裕之, 日本薬学会年会要旨集, Vol. 127th, No. 3, 2007
腫瘍特異的プロモーター搭載アデノウイルスベクターを用いた自殺遺伝子治療, 姚醒蕾,吉岡靖雄,吉岡靖雄,衛藤佑介,水口裕之,水口裕之,岡田裕香,向洋平,岡田直貴,中川晋作,中川晋作, 日本薬学会年会要旨集, Vol. 127th, No. 3, 2007
癌遺伝子治療の最適化を目指した高機能化アデノウイルスベクターの創製, 吉岡靖雄,向洋平,水口裕之,岡田直貴,中川晋作, 日本学術会議材料工学連合講演会講演論文集, Vol. 51st, 2007
アデノウイルスベクターを用いたマウス胚様体への遺伝子導入法の確立, 田代克久,田代克久,川端健二,桜井晴奈,桜井晴奈,倉知慎之輔,倉知慎之輔,櫻井文教,中川晋作,早川堯夫,山西弘一,水口裕之,水口裕之, 日本薬学会年会要旨集, Vol. 127th, No. 3, 2007
LIGHT発現樹状細胞の定着腫瘍に対する抗腫瘍効果とその作用機序, 高橋正也,金川尚子,後藤美千代,柳川達也,水口裕之,水口裕之,向洋平,吉岡靖雄,吉岡靖雄,岡田直貴,中川晋作,中川晋作, Drug Delivery System, Vol. 22, No. 3, 2007
アデノウイルスベクターを用いたマウス胚様体への遺伝子導入法の確立, 田代克久,田代克久,川端健二,桜井晴奈,桜井晴奈,倉知慎之輔,倉知慎之輔,櫻井文教,中川晋作,山西弘一,水口裕之,水口裕之, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 7th, 2007
全身投与による癌遺伝子治療の最適化を目指した高分子バイオコンジュゲート化アデノウイルスベクターの創製, 衛藤佑介,吉岡靖雄,吉岡靖雄,森重智弘,姚醒蕾,倉知慎之輔,水口裕之,水口裕之,堤康央,堤康央,向洋平,岡田直貴,中川晋作,中川晋作, 遺伝子・デリバリー研究会シンポジウム要旨集, Vol. 7th, 2007
Adenovirus Vector Carrierとしての細胞膜透過性ペプチド, 喜田進也,前田光子,北條恵子,衛藤佑介,森重智弘,渡辺光,ASAVATANABODEE Ratima,吉岡靖雄,吉岡靖雄,水口裕之,水口裕之,真弓忠範,中川晋作,川崎紘一, 日本薬学会年会要旨集, Vol. 127th, No. 4, 2007
広範な感染域を有するTatペプチド修飾アデノウイルスベクターの作製と遺伝子導入特性評価, ASAVATANABODEE Ratima,吉岡靖雄,吉岡靖雄,衛藤佑介,喜田進也,前田光子,水口裕之,水口裕之,向洋平,岡田直貴,川崎紘一,中川晋作,中川晋作, 日本薬学会年会要旨集, Vol. 127th, No. 3, 2007
標的指向能を付与したバイオコンジュゲート化アデノウイルスベクターの創製, 衛藤佑介,吉岡靖雄,吉岡靖雄,ASAVATANABODEE Ratima,水口裕之,水口裕之,向洋平,岡田直貴,中川晋作,中川晋作, 日本バイオマテリアル学会大会予稿集, Vol. 29th, 2007
INFECTIOUS MECHANISM OF ADENOVIRUS VECTOR IN CACO-2 CELL FOR PERMEABILITY STUDY USING A TRANSGENE EXPRESSED INTESTINAL EPITHELIUM MODEL, Naoya Koizumi,Tomomi Sasaki,Hiroyuki Mizuguchi,Makiko Fujii,Yoshiteru Watanabe, DRUG METABOLISM REVIEWS, TAYLOR & FRANCIS INC, Vol. 39, p. 35-36, 2007
Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin, Motoki Harada,Masuo Kondoh,Chiaki Ebihara,Azusa Takahashi,Eriko Komiya,Makiko Fujii,Hiroyuki Mizuguchi,Shin-Ichi Tsunoda,Yasuhiko Horiguchi,Kiyohito Yagi,Yoshiteru Watanabe, BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 73, No. 2, p. 206-214, 2007/01
Systemic Administration of PEGylated Adenovirus Vector Enhances Vector Accumulation and Gene Expression in Tumors and Improves Anti-tumor Effects in Cytokine Gene Therapy, Gao J.Q,Eto Y,Yoshioka Y,Sekiguchi F,Kurachi S,Morishige T,Yao X,Watanabe H,Asavatanabodee R,Sakurai F,Mizuguchi H,Okada Y,Mukai Y,Tsutsumi Y,Mayumi T,Okada N,Nakagawa S, J. Control. Release, Vol. 122, No. 1, p. 102-110, 2007
Downregulation of CD46 by adenovirus serotype 35 vectors, Fuminori Sakurai,Kimiyo Akitomo,Kenji Kawabata,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 12, p. 1466-1466, 2006/12
Elimination of innate immune responses by capsid-modification of adenovirus vectors, Naoya Koizumi,Kenji Kawabata,Fuminori Sakurai,Takao Hayakawa,Yoshiteru Watanabe,Hiroyuki Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 12, p. 1467-1467, 2006/12
CX3CL1遺伝子導入骨髄由来間葉系幹細胞(MSC)の気道投与による多発肺腫瘍の抑制, 辛紅,兼平雅彦,水口裕之,早川堯夫,貫和敏博,西條康夫, 肺癌, (NPO)日本肺癌学会, Vol. 46, No. 5, p. 535-535, 2006/11
癌遺伝子治療の最適化を目指したTatペプチド修飾アデノウイルスベクターの作製と遺伝子導入特性評価, 渡辺光,衛藤佑介,森重智弘,喜田進也,前田光子,水口裕之,吉岡靖雄,岡田直貴,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 65回, p. 44-44, 2006/09
PEGylationと腫瘍特異的プロモーターの併用による腫瘍標的化アデノウイルスベクターの最適化, 森重智弘,衛藤佑介,倉知慎之介,渡辺光,岡田裕香,水口裕之,吉岡靖雄,岡田直貴,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 65回, p. 44-44, 2006/09
CCL27遺伝子共導入によるIL-12癌遺伝子治療の有効性改善と副作用軽減, 金川尚子,畑中豊,谷洋一,水口裕之,岡田直貴,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 65回, p. 44-44, 2006/09
Enhancement of Human Monocyte-Derived Dendritic Cell Functions by Adenovirus-Mediated RNA Interference of STAT-3, Tomoko Iwata,Hidetoshi Sumimoto,Hiroyuki Mizuguchi,Yutaka Kawakami, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 13, p. S162-S162, 2006/05
Development of adenovirus vectors composed of human subgroup B adenoviruses, SAKURAI Fuminori,MIZUGUCHI Hiroyuki, Bioscience & industry, Vol. 64, No. 5, p. 255-260, 2006/05/01
Mechanism of Difference in the Transcription Activity of Nucleus-Delivered Transgene Introduced by Adenovirus and Lipoplex, Hidetaka Akita,Susumu Hama,Hiroyuki Mizuguchi,Hideyoshi Harashima, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 13, p. S199-S199, 2006/05
Development of Modified Adenovirus Vectors with Reduced Innate Immune Response, Hiroyuki Mizuguchi,Naoya Koizumi,Kenji Kawabata,Fuminori Sakurai,Takao Hayakawa, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 13, p. S57-S58, 2006/05
Adenovirus Serotype 35 Vector-Mediated Transduction in Mouse Hematopoietic Stem Cells Isolated from Human CD46-Transgenic Mice, Fuminori Sakurai,Kenji Kawabata,Takao Hayakawa,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 13, p. S52-S53, 2006/05
Transductional and transcriptional tumor-targeting using adenoviral vector with PEGylation and TERT promoter on systemic administration into tumor-bearing mice, Yusuke Eto,Shinnosuke Kurachi,Tomohiro Morishige,Xinglei Yao,Hikaru Watanabe,Yuka Okada,Hiroyuki Mizuguchi,Yasuo Tsutsumi,Naoki Okada,Shinsaku Nakagawa, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 66, No. 8, 2006/04
アポトーシス抵抗性樹状細胞の創製と抗腫ようワクチン機能の評価, 丹羽貴子,吉川友章,後藤美千代,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
IL‐12発現ベクターを投与した腫よう組織における免疫イベントの解析, 金川尚子,吉川友章,畑中豊,谷洋一,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006/03/06
RNAi誘導用レンチウイルスベクターの改良とその応用:Doxycycline‐inducible shRNA expression by a single lentiviral vector, 形山和史,水口裕之,川端健二,細野哲二,清水なつみ,須永裕之,立花雅史,中川晋作,三好浩之, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126th, No. 2, p. 137-137, 2006/03/06
Enhanced anti-tumor responses induced by the combination of a couple of stimulators: IL-12 and CCL27, T Sugita,JQ Gao,N Kanagawa,Y Motomura,T Nakayama,O Yoshie,Y Hatanaka,Y Tani,H Mizuguchi,Y Tsutsumi,S Nakagawa, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 397-397, 2006/03
ポリエチレングリコール修飾アデノウイルスベクターを用いた腫瘍標的化自殺遺伝子治療の開発, 姚醒蕾,衛藤佑介,倉知慎之輔,森重智弘,渡辺光,岡田裕香,水口裕之,堤康央,岡田直貴,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126年会, No. 2, p. 139-139, 2006/03
ケモカイン・サイトカイン遺伝子を導入した樹状細胞の創製と抗腫瘍効果の評価, 上羽美貴,岡田直貴,木村芳伸,郷谷真嗣,藤井愛,水口裕之,中川晋作,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126年会, No. 2, p. 139-139, 2006/03
TERT遺伝子を導入した樹状細胞ワクチンの腫瘍増殖抑制効果, 大西康司,岡田直貴,森川愉加里,水口裕之,中川晋作,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 126年会, No. 2, p. 139-139, 2006/03
Adenovirus serotype 35 vector-mediated transduction in human hematopoietic progenitors, F Sakurai,K Kawabata,T Yamaguchi,T Hayakawa,H Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 403-404, 2006/03
Ablating CAR and integrins binding and fiber shaft exchange in adenovirus vectors reduces tissue transduction and toxicity after systemic administration, N Koizumi,K Kawabata,F Sakurai,Y Watanabe,T Hayakawa,H Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 404-404, 2006/03
Mobilization of hematopoietic progenitor cells and pre-b cells from the bone marrow by a SDF-1-expressing fiber-modified adenovirus vector, K Kawabata,F Sakurai,N Koizumi,T Hayakawa,H Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 402-402, 2006/03
Characterization of adenovirus serotype 35 vector-mediated in vivo transduction using human CD46-transgenic mice, F Sakurai,K Kawabata,N Koizumi,N Inoue,M Okabe,T Yamaguchi,T Hayakawa,H Mizuguchi, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 8, No. 3, p. 382-383, 2006/03
アデノウイルスベクターによる樹状細胞の表現型変化とその作用機序に関する基礎的検討, 是友良介,岡田直貴,村上さやか,大西善洋,水口裕之,中川晋作,藤田卓也,山本昌, 薬剤学, (公社)日本薬剤学会, Vol. 66, No. Supplement, p. 301-301, 2006/02/24
腫よう標的化を目指した改良型アデノウイルスベクターの創製, 森重智弘,衛藤佑介,倉知慎之輔,よう醒らい,渡辺光,岡田裕香,水口裕之,堤康央,岡田直貴,中川晋作, 薬剤学, Vol. 66, No. Supplement, 2006
Tatペプチド修飾アデノウイルスベクターの開発と遺伝子導入特性に関する検討, 渡辺光,衛藤佑介,森重智弘,姚醒蕾,吉岡靖雄,喜田進也,前田光子,川崎紘一,水口裕之,水口裕之,岡田直貴,中川晋作, Drug Delivery System, Vol. 21, No. 3, 2006
非特異的遺伝子導入抑制を目指したファイバー欠損アデノウイルスベクターの開発とその特性評価, 倉知慎之輔,倉知慎之輔,小泉直也,桜井晴奈,桜井晴奈,佐々木朋美,櫻井文教,川端健二,中川晋作,早川堯夫,水口裕之,水口裕之, Drug Delivery System, Vol. 21, No. 3, 2006
免疫細胞の腫よう内動員を基盤とした新規癌免疫遺伝子治療の開発, 丹羽正和,岡田直貴,熊谷将成,畑中豊,谷洋一,水口裕之,中川晋作,藤田卓也,山本昌, 薬剤学, Vol. 66, No. Supplement, 2006
Lipoplexとアデノウイルスベクターのin vivoにおける遺伝子発現能および自然免疫誘導能の比較, 桜井晴奈,桜井晴奈,桜井文教,佐々木朋美,川端健二,小泉直也,黄海瑛,倉知慎之輔,倉知慎之輔,中川晋作,水口裕之,水口裕之, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006
マウスT細胞への遺伝子導入効率に優れるベクターシステムの探索, 本村吉章,吉川友章,柳川達矢,杉田敏樹,杉田敏樹,水口裕之,水口裕之,堤康夫,堤康夫,岡田直貴,中川晋作, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006
アポトーシス抵抗性を付与した樹状細胞の生体内生存期間延長と免疫誘導との連関評価, 後藤美千代,丹羽貴子,丹羽貴子,吉川友章,吉川友章,水口裕之,水口裕之,岡田直貴,岡田直貴,中川晋作,中川晋作, Drug Delivery System, Vol. 21, No. 3, 2006
抗アポトーシス分子を導入した樹状細胞ワクチンの特性と抗腫ようメカニズムの解析, 後藤美千代,丹羽貴子,丹羽貴子,吉川友章,吉川友章,水口裕之,水口裕之,岡田直貴,岡田直貴,中川晋作, 薬剤学, Vol. 66, No. Supplement, 2006
カプシド改変アデノウイルスベクターの作製とその機能性評価, 倉知慎之輔,倉知慎之輔,小泉直也,桜井晴奈,桜井晴奈,桜井文教,川端健二,中川晋作,早川あき夫,水口裕之,水口裕之, 日本薬学会年会要旨集, Vol. 126th, No. 2, 2006
RNAi誘導用レンチウイルスベクター:Tetracycline‐inducible shRNA expression by a single lentiviral vector, 形山和史,水口裕之,川端健二,細野哲二,清水なつみ,須永裕之,立花雅史,中川晋作,三好浩之, 日本分子生物学会年会講演要旨集, Vol. 28th, 2005/11/25
変異型抗アポトーシス蛋白質Bcl-xFNK発現樹状細胞を用いた抗腫瘍効果に関する検討, 丹羽貴子,吉川友章,小田淳史,飯田恵介,松尾一彦,萱室裕之,岡田直貴,堤康央,水口裕之,中川晋作, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 120-120, 2005/11
IL-12発現ベクターの腫瘍内投与による抗腫瘍効果と免疫系細胞の腫瘍内浸潤の向上, 金川尚子,杉田敏樹,飯田恵介,畑中豊,谷洋一,水口裕之,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 130-130, 2005/11
骨髄由来間葉系幹細胞(MSC)を用いた癌組織をターゲッティングする免疫遺伝子細胞治療開発, 辛紅,兼平雅彦,鈴木拓児,前門戸任,菊地利明,水口裕之,早川尭夫,貫和敏博,西條康夫, 日本癌学会総会記事, 日本癌学会, Vol. 64回, p. 315-315, 2005/09
腫瘍特異的プロモーターを搭載したファイバー改変型アデノウイルスベクターによるマウスメラノーマ自殺遺伝子治療, 岡田直貴,岡田裕香,水口裕之,早川尭夫,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 64回, p. 356-356, 2005/09
腫瘍ターゲティングを目指したバイオコンジュゲート化アデノウイルスベクターの開発, 衛藤佑介,倉知慎之輔,水口裕之,堤康央,早川尭夫,真弓忠範,中川晋作, 日本癌学会総会記事, 日本癌学会, Vol. 64回, p. 408-408, 2005/09
遺伝子デリバリーシステムの細胞内動態の定量的解析 : ウイルスvs非ウイルス, 秋田英万,濱進,水口裕之,原島秀吉, Drug delivery system, Vol. 20, No. 3, p. 279-279, 2005/05/10
IL-12発現アデノウイルスベクターの腫瘍内投与による抗腫瘍効果と免疫細胞の腫瘍内浸潤, 金川尚子,杉田敏樹,高建青,本村吉章,飯田恵介,柳川達也,堤康央,水口裕之,真弓忠範,中川晋作, Drug Delivery System, 日本DDS学会, Vol. 20, No. 3, p. 359-359, 2005/05
カプシドタンパク質を改変した改良型アデノウイルスベクターによる高効率遺伝子導入 (特集ナノメディシン(part2)), 水口裕之,早川堯夫, バイオインダストリー, シーエムシー出版, Vol. 22, No. 5, p. 16-21, 2005/05
ウイルスベクター, 水口裕之,早川堯夫, Drug delivery system, Vol. 20, No. 2, p. 158-159, 2005/03/10
IL-12とCCL27の併用による抗腫瘍効果増強機構の解明, 杉田敏樹,高建青,金川尚子,飯田恵介,本村吉章,畑中豊,谷一,中山隆志,義江修,水口裕之,早川尭夫,岡田直貴,堤康央,弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 154-154, 2005/03
変異型Bcl-XL(FNK)遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化(1), 丹羽貴子,吉川友章,小田淳史,下川摩里子,岡田直貴,堤康央,水口裕之,早川尭夫,麻生定光,太田成男,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 91-91, 2005/03
変異型Bcl-XL(FNK)遺伝子導入樹状細胞を用いた腫瘍ワクチン療法の最適化(2), 吉川友章,丹羽貴子,小田淳史,下川摩里子,岡田直貴,堤康央,水口裕之,早川尭夫,麻生定光,太田成男,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 91-91, 2005/03
IL-12発現アデノウイルスベクターを用いたIL-12非奏功性腫瘍に対する治療効果に関する検討, 金川尚子,高建青,杉田敏樹,飯田恵介,衛藤佑介,本村吉章,水口裕之,早川尭夫,堤康央,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 153-153, 2005/03
Polyethylene Glycol修飾アデノウイルスベクターの腫瘍集積性に関する検討, 倉知慎之輔,衛藤佑介,高建青,森重智弘,櫻井文教,水口裕之,早川尭夫,堤康央,真弓忠範,中川晋作, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 2, p. 154-154, 2005/03
胎盤由来細胞への改良型アデノウイルスベクターによる遺伝子導入効率の検討, 小泉直也,近藤昌夫,水口裕之,中西剛,藤井まき子,早川尭夫,中島恵美,田中慶一,渡辺善照, 薬剤学: 生命とくすり, (公社)日本薬剤学会, Vol. 65, No. Suppl., p. 179-179, 2005/03
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターの腫瘍集積性に関する検討, 衛藤佑介,高建青,倉知慎之輔,森重智弘,櫻井文教,水口裕之,早川堯夫,提康央,真弓忠範,中川晋作, 薬剤学, Vol. 65, No. Supplement, 2005
IL-12及びCCL27発現アデノウイルスベクターの併用投与による抗腫よう効果とその有用性評価, 杉田敏樹,高建青,金川尚子,本村吉章,飯田恵介,堤康央,水口裕之,義江修,真弓忠範,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005
IL-12及びCCL27発現アデノウイルスベクターの併用投与による抗腫よう効果増強機構の解明, 本村吉章,杉田敏樹,高建青,金川尚子,飯田恵介,堤康央,堤康央,水口裕之,水口裕之,義江修,真弓忠範,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005
IL-12発現アデノウイルスベクターの腫よう内投与による抗腫よう効果と免疫細胞の腫よう内浸潤, 金川尚子,杉田敏樹,高建青,本村吉章,飯田恵介,柳川達也,堤康央,水口裕之,真弓忠範,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005
IL-12発現ベクターの腫よう内投与による抗腫よう効果と免疫系細胞の腫よう内浸潤の向上, 金川尚子,杉田敏樹,飯田恵介,畑中豊,谷洋一,水口裕之,水口裕之,堤康央,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, Vol. 35, 2005
活性増強変異型抗アポトーシス蛋白質Bcl-xFNK発現樹状細胞を用いた腫ようワクチン療法, 丹羽貴子,丹羽貴子,吉川友章,吉川友章,小田淳史,小田淳史,飯田恵介,飯田恵介,松尾一彦,松尾一彦,下川摩里子,岡田直貴,堤康央,堤康央,水口裕之,水口裕之,中川晋作,中川晋作, Drug Delivery System, Vol. 20, No. 3, 2005
標的細胞へのターゲティングを目指した抗体結合能を持つアデノウイルスベクターの開発, 小泉直也,水口裕之,中川晋作,真弓忠範,渡辺善照,早川尭夫, 日本薬学会年会要旨集, Vol. 125th, No. 2, 2005
Synthesis of a RGD peptide-PEG hybrid for carrying adenovirus vector into cells, S Kida,M Maeda,K Hojo,Y Eto,JQ Gao,S Kurachi,F Sekiguchi,H Mizuguchi,T Hayakawa,T Mayumi,S Nakagawa,K Kawasaki, BIOPOLYMERS, JOHN WILEY & SONS INC, Vol. 80, No. 4, p. 570-570, 2005
Analysis of immune cell-recruitment and tumor suppressive effect in murine B16BL6 melanoma injected with chemokine-expressing adenoviral vector, M Niwa,N Okada,A Sasaki,Y Hatanaka,Y Tani,H Mizuguchi,S Nakagawa,T Fujita,A Yamamoto, DRUG METABOLISM REVIEWS, TAYLOR & FRANCIS INC, Vol. 37, No. 4, p. 725-726, 2005
ケモカイン発現ベクターの腫瘍内投与による抗腫瘍効果と免疫細胞浸潤, 岡田直貴,中川晋作,畑中豊,谷洋一,中山隆志,義江修,水口裕之,早川高夫,藤田卓也,山本昌, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 215-215, 2004/11
IL-12及びCCL27発現アデノウイルスベクターの併用投与による抗腫瘍効果と免疫系細胞の浸潤, 杉田敏樹,畑中豊,谷洋一,中山隆志,義江修,水口裕之,早川高夫,岡田直貴,堤康央,真弓忠範,中川晋作, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 215-215, 2004/11
リンパ組織指向性樹状細胞の創製と癌免疫療法への応用, 岡田直貴,水口裕之,早川尭夫,義江修,中川晋作,藤田卓也,山本昌, 日本癌学会総会記事, 日本癌学会, Vol. 63回, p. 435-435, 2004/09
ドキシサイクリン誘導型siRNA発現アデノウイルスベクターの開発, 細野哲司,水口裕之,中川晋作,山口照英,真弓忠範,早川尭夫, 日本癌学会総会記事, 日本癌学会, Vol. 63回, p. 507-507, 2004/09
Antibody-targeted fusion provides a versatile platform for novel targeted therapies, T Nakamura,KW Peng,S Vongpunsawad,M Harvey,H Mizuguchi,T Hayakawa,R Cattaneo,SJ Russell, MOLECULAR THERAPY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 9, p. S10-S10, 2004/05
Role of CD46 on Ad35 vector-mediated transduction, F Sakurai,H Mizuguchi,K Kawabata,N Inoue,M Okabe,T Yamaguchi,T Hayakawa, MOLECULAR THERAPY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 9, p. S44-S44, 2004/05
ケモカイン発現ベクターの腫瘍内投与を併用した樹状細胞ワクチンの抗腫瘍効果, 佐々木明徳,岡田直貴,丹羽正和,岡田裕香,中山隆志,義江修,畑中豊,谷洋一,水口裕之,早川尭夫,中川晋作,真弓忠範,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 112-112, 2004/03
shRNA発現レンチウイルスベクターを用いたPPARγノックダウン法の確立, 大橋興三,形山和史,和田孝一郎,三好浩之,水口裕之,立花雅史,古木理恵,中島淳,門脇孝,堤康央,中川晋作,早川尭夫,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 4, p. 114-114, 2004/03
siRNA発現アデノウイルスベクターによるRNAi効果に関する検討, 細野哲司,水口裕之,福島敬,佐々木朋美,石井明子,形山和史,中川晋作,山口照英,真弓忠範, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
ポリエチレングリコール修飾アデノウイルスベクターの体内動態に関する検討, 衛藤佑介,倉知慎之輔,高建青,形山和史,堤康央,水口裕之,早川尭夫,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
PPARγに対するsiRNA発現アデノウイルスベクターを用いた培養マウス脂肪前駆細胞の分化抑制, 細野哲司,水口裕之,形山和史,中川晋作,山口照英,真弓忠範,早川尭夫, Drug Delivery System, Vol. 19, No. 3, 2004
体内動態制御を目指したポリエチレングリコール修飾アデノウイルスベクターのin vivo遺伝子発現特性に関する検討, 倉知慎之輔,衛藤佑介,高建青,堤康央,水口裕之,早川尭夫,真弓忠範,中川晋作, Drug Delivery System, Vol. 19, No. 3, 2004
抗原遺伝子とIL-12遺伝子を共導入した樹状細胞のT細胞感作・活性化能, 井上恵美子,岡田直貴,飯山さやか,松井あや,岡田裕香,水口裕之,早川尭夫,中川晋作,真弓忠範, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
リンパ組織移行性を増強した樹状細胞ワクチンの創製, 森直樹,岡田直貴,是友良介,岡田裕香,中山隆志,義江修,水口裕之,早川尭夫,中川晋作, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
ケモカイン発現ベクターの腫よう内投与を併用した樹状細胞ワクチンの抗腫よう効果, 佐々木明徳,岡田直貴,丹羽正和,岡田裕香,中山隆志,義江修,畑中豊,水口裕之,中川晋作, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
shRNA発現レンチウイルスベクターの作製と機能評価, 形山和史,三好浩之,水口裕之,立花雅史,大橋興三,古木理恵,川端健二,堤康央,中川晋作, 日本薬学会年会要旨集, Vol. 124th, No. 4, 2004
ケモカイン遺伝子導入を併用したDC癌免疫療法プロトコールの有効性評価, 佐々木明徳,岡田直貴,中山隆志,義江修,畑中豊,谷洋一,中川晋作,早川高夫,水口裕之, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 33, p. 327-327, 2003/11/05
Suppressor of cytokine signaling-3 prevents leptin inhibition of human insulin gene transcription., H Yamasaki,K Oshima,A Kita,S Uotani,R Takahashi,T Fukushima,H Kuwahara,T Hayakawa,H Mizuguchi,Y Nagayama,N Abiru,E Kawasaki,Y Yamaguchi,K Eguchi, DIABETOLOGIA, SPRINGER-VERLAG, Vol. 46, p. A225-A225, 2003/08
遺伝子機能解析のための遺伝子導入ベクター--ウイルスベクターを中心として (化学と生物学の接点がつくるNewバイオテクノロジー) -- (遺伝子発現をあやつる), 水口裕之,早川尭夫, 蛋白質核酸酵素, 共立出版, Vol. 48, No. 11, p. 1653-1662, 2003/08
Characterization of in vivo gene transfer property of an adenovirus serotype 35 vector, H Mizuguchi,F Sakurai,T Yamaguchi,T Hayakawa, MOLECULAR THERAPY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 7, No. 5, p. S193-S193, 2003/05
Efficient gene transfer into human CD 34(+) cells and cultured blood cell lines by an adenovirus serotype 35 vector, F Sakurai,H Mizuguchi,T Hayakawa, MOLECULAR THERAPY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 7, No. 5, p. S202-S202, 2003/05
ケモカイン及びサイトカイン発現アデノウイルスベクターの併用による癌遺伝子治療の最適化, 高建青,形山和史,SOARES A L,水口裕之,早川尭夫,中山隆志,義江修,堤康央,中川晋作, 薬剤学, (公社)日本薬剤学会, Vol. 63, No. Supplement, p. 232-232, 2003/03/05
ケモカイン発現RGDファイバーミュータントアデノウイルスベクターの樹状細胞免疫療法への応用に関する基礎的検討, 佐々木明徳,岡田直貴,大久保米起,岡田裕香,中山隆志,水口裕之,中川晋作,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 81-81, 2003/03/05
RGDファイバーミュータントアデノウイルスベクターにより抗原遺伝子とIL‐12遺伝子を共導入した樹状細胞の特性, 岡田直貴,飯山さやか,西田雅也,舛永安繁,岡田裕香,水口裕之,早川尭夫,中川晋作,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123rd, No. 4, p. 82-82, 2003/03/05
ヒト胎盤由来細胞へのアデノウイルスベクターによる遺伝子導入効率の検討, 小泉直也,増山茜,近藤昌夫,藤井まき子,水口裕之,早川堯夫,中島恵美,宇都口直樹,渡辺善照, 薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, (公社)日本薬剤学会, Vol. 63, No. Suppl., p. 233-233, 2003/03/05
RGDファイバーミュータントアデノウイルスベクターによりメラノーマ関連抗原遺伝子を導入した樹状細胞の腫瘍免疫誘導機序の解析, 森直樹,岡田直貴,舛永安繁,井上恵美子,山中美由紀,岡田裕香,水口裕之,早川尭夫,中川晋作,真弓忠範,藤田卓也,山本昌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 4, p. 82-82, 2003/03
RGDペプチドを付与したポリエチレングリコール修飾アデノウイルスベクターの機能評価, 関口文子,衛藤佑介,高健青,形山和史,堤康央,前田光子,川崎紘一,水口裕之,中川晋作, 日本薬学会年会要旨集, Vol. 123rd, No. 4, 2003
改良型アデノウイルスベクターを用いた胎盤への遺伝子導入, 立花雅史,形山和史,古木理恵,大橋興三,堤康央,中川晋作,水口裕之,早川尭夫,真弓忠範, 日本薬学会年会要旨集, Vol. 123rd, No. 4, 2003
PPAR gamma-gene therapy of inflammatory bowel disease (IBD)., K Katayama,K Wada,A Nakajima,M Tachibana,H Mizuguchi,T Hayakawa,T Ariyama,S Nakagawa,T Kadowaki,Y Kamisaki,RS Blumberg,T Mayumi, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 91, p. 167P-167P, 2003
Soluble CAR-SCF fusion, protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells., A Itoh,T Okada,H Mizuguchi,T Hayakawa,H Mizukami,M Takatoku,N Komatsu,A Kume,Y Hanazono,K Ozawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 100, No. 11, p. 654A-654A, 2002/11
改良型 tet-on システムを搭載したアデノウイルスベクターによる効率の良い目的遺伝子の発現制御システムの開発, 水口裕之,櫻井文教,早川堯夫, Drug delivery system, Vol. 17, No. 3, p. 237-237, 2002/05/10
PPARγ発現アデノウイルスベクターによる炎症性腸疾患治療法の開発, 形山和史,和田孝一郎,中島淳,吉田幸子,立花雅史,水口裕之,早川堯夫,堤康央,中川晋作,上崎善規,門脇孝,永井良三,真弓忠範, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 122年会, No. 4, p. 12-12, 2002/03
Approaches for generating recombinant adenovirus vectors, Hiroyuki Mizuguchi,Mark A Kay,Takao Hayakawa, Advanced Drug Delivery Reviews, Vol. 52, No. 3, p. 165-176, 2001/11/19
プラスミド構築に基づいた組換えアデノウイルスベクター作製技術, 水口裕之,早川堯夫, バイオインダストリ-, シ-エムシ-, Vol. 18, No. 7, p. 5-14, 2001/07
ファイバーミュータントアデノウイルスベクターによる樹状細胞への遺伝子導入効率と機能修飾, 岡田直貴,藤本京子,塚田有希子,中川晋作,真弓忠範,水口裕之,早川尭夫,藤田卓也,山本昌, 薬剤学, (公社)日本薬剤学会, Vol. 61, No. Suppl., p. 76-76, 2001/03/05
Adenovirus-mediated MUC1 gene transduction into human blood-derived dendritic cells, K. Maruyama,Y. Akiyama,N. Nara-Ashizawa,T. Hojo,J. Cheng,H. Mizuguchi,T. Hayakawa,K. Yamaguchi, Journal of Immunotherapy, Vol. 24, No. 4, p. 345-353, 2001
Nuclear targeting of DNA, Mahito Nakanishi,Teruo Akuta,Emi Nagoshi,Akiko Eguchi,Hiroyuki Mizuguchi,Takao Senda, European Journal of Pharmaceutical Sciences, Vol. 13, No. 1, p. 17-24, 2001
プラスミドの複製・安定性に関与するヒトDNA配列の探索, 内田恵理子,水口裕之,石井明子[渡部],日向昌司,早川尭夫, 生化学, (公社)日本生化学会, Vol. 72, No. 8, p. 953-953, 2000/08
ターゲッティングに応用可能な新規アデノウイルスベクターの開発, 水口裕之,早川堯夫, Drug delivery system, Vol. 15, No. 4, p. 306-307, 2000/07/10
Growth inhibition of human leukemia HL-60 cells by an antisense phosphodiester oligonucleotide encapsulated into fusogenic liposomes, Masuo Kondoh,Takahiro Matsuyama,Ryo Suzuki,Hiroyuki Mizuguchi,Tsuyoshi Nakanishi,Shinsaku Nakagawa,Yasuo Tsutsumi,Mahito Nakanishi,Masao Sato,Tadanori Mayumi, Biological and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, Vol. 23, No. 8, p. 1011-1013, 2000
HOT PRESS in vitroライゲーションに基づいた簡便なアデノウイルスベクター作製法, 水口裕之,早川尭夫, 細胞工学, 秀潤社, Vol. 18, No. 12, p. 1824-1827, 1999/12
簡便なアデノウイルスベクター作製法の開発と次世代ベクターへの応用, 水口裕之,早川堯夫, Drug delivery system, Vol. 14, No. 4, p. 255-255, 1999/07/10
アデノウイルスベクターの最近の進歩--免疫反応の抑制を目指した改良型ベクターの開発を中心に, 水口裕之,早川尭夫, 蛋白質核酸酵素, 共立出版, Vol. 44, No. 9, p. 1405-1414, 1999/07
膜融合リポソームのDNAワクチンベクターとしての基礎的検討, 今津進,林和行,中西剛,中川哲彦,堤康央,中川晋作,真弓忠範,中西真人,水口裕之,早川尭夫, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 119年会, No. 4, p. 17-17, 1999/03
Fusion of Sendai virus with liposome depends on only F protein, but not HN protein, H Mizuguchi,T Nakanishi,M Kondoh,T Nakagawa,M Nakanishi,T Matsuyama,Y Tsutsumi,S Nakagawa,T Mayumi, VIRUS RESEARCH, ELSEVIER SCIENCE BV, Vol. 59, No. 2, p. 191-201, 1999/02
Application of T7 expression system to a cytoplasmic gene expression using fusogenic liposomes, T. Nakagawa,H. Mizuguchi,R. Suzuki,R. Nakano,K. Katayama,Y. Tsutsumi,S. Nakagawa,T. Hayakawa,M. Nakanishi,T. Mayumi, Proceedings of the Controlled Release Society, p. 763-764, 1999/01/01
Different reactions of aortic and venular endothelial cell monolayers to histamine on macromolecular permeability: Role of cAMP, cytosolic Ca2+ and F-actin, Kenji Ikeda,Naoki Utoguchi,Hiroo Makimoto,Hiroyuki Mizuguchi,Shinsaku Nakagawa,Tadanori Mayumi, Inflammation, Kluwer Academic/Plenum Publishers, Vol. 23, No. 1, p. 87-97, 1999
Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors, H Mizuguchi,T Nakagawa,S Toyosawa,M Nakanishi,S Imazu,T Nakanishi,Y Tsutsumi,S Nakagawa,T Hayakawa,N Ijuhin,T Mayumi, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 58, No. 24, p. 5725-5730, 1998/12
The optimization of cytoplasmic gene expression system with T7 RNA polymerase, Ryo Suzuki,Tetsuhiko Nakagawa,Hiroyuki Mizuguchi,Susumu Imazu,Tsuyoshi Nakanishi,Shinsaku Nakagawa,Tadanori Mayumi,Mahito Nakanishi,Takao Hayakawa, Drug Delivery System, Vol. 13, No. 2, p. 87-93, 1998
細胞内への遺伝子ターゲッティング法の開発, 中西真人,水口裕之,芥照夫,名越絵美,真弓忠範,早川堯夫, Drug delivery system, Vol. 12, No. 4, p. 251-251, 1997/07/10
Induction reinforcement of antitumor immunity using cationic liposome as tumor vaccine vector., 中西剛,国沢純,林哲,久保一義,中川晋作,堤康央,水口裕之,藤原大美,浜岡利之, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Particle design of optimal membrane fusion liposome as a gene transfer vector., 鈴木亮,中川哲彦,堤康央,久保一義,中川晋作,真弓忠範,水口裕之,中西真人, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997/03
Antitumor vaccine effect reinforcement of liposome adjuvant by cationization., 国沢純,中西剛,林哲,久保一義,中川晋作,堤康央,水口裕之,藤原大美,浜岡利之, 日本薬学会年会要旨集, Vol. 117th, No. 4, 1997
Selective enhancement by tumor necrosis factor-alpha of vascular permeability of new blood vessels induced with agarose hydrogel-entrapped Meth-A fibrosarcoma cells, N Okada,Y Kaneda,H Miyamoto,Y Yamamoto,H Mizuguchi,Y Tsutsumi,S Nakagawa,T Mayumi, JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, Vol. 87, No. 8, p. 831-836, 1996/08
Sendai virus vectors: New systems for gene transfer and expression, M Nakanishi,H Mizuguchi,K Ashihara,T Senda,E Nagoshi,T Akuta,T Kondoh,T Mayumi, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION, Vol. 21, No. 1, p. 92-94, 1996/07
Nishiseto Expressway's Kurushima Bridge-World's First Three Continuous Suspension Bridges-, MIZUGUCHI Hiroyuki, Vol. 81, No. 3, p. 2-5, 1996/03/15
固形癌遺伝子治療に対する新しい戦略腫瘍支配動脈内へのTNF-α遺伝子導入による抗腫瘍効果の誘導, 中川哲彦,水口裕之,今津進,森岡裕香,中川晋作,真弓忠範,中西真人, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 116年会, No. 4, p. 78-78, 1996/03
Intratumor administration of fusogenic liposomes containing fragment A of diphtheria toxin suppresses tumor growth, H Mizuguchi,T Nakanishi,M Nakanishi,T Nakagawa,S Nakagawa,T Mayumi, CANCER LETTERS, ELSEVIER IRELAND LTD, Vol. 100, No. 1-2, p. 63-69, 1996/02
Direct gene transfer into living cells using fusogenic liposome, S Nakagawa,H Mizuguchi,M Nakanishi,T Mayumi, 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, CONTROLLED RELEASE SOCIETY INC, p. 893-894, 1996
Characterization of fusogenic liposomes as a gene transfer vector, Tetsuhiko Nakagawa,Hiroyuki Mizuguchi,Susumu Imazu,Shinsaku Nakagawa,Tadanori Mayumi,Mahito Nakanishi,Takao Hayakawa, Drug Delivery System, Vol. 11, No. 6, p. 411-417, 1996
遺伝子封入膜融合リポソームを用いた培養細胞への遺伝子導入, 中川哲彦,水口裕之,今津進,中川晋作,真弓忠範,内西真人, 日本薬学会年会要旨集, Vol. 115th, No. Pt 4, 1995
HVJとリポソームとの融合機構の解明, 中西剛,水口裕之,中川哲彦,近藤昌夫,中川晋作,真弓忠範,中西真人, 日本薬学会年会要旨集, Vol. 115th, No. Pt 4, 1995
Glial-conditioned medium elevates alkaline phosphatase activity in cultured bovine aortic endothelial cells, Hiroyuki Mizuguchi,Akiko Fujii,Naoki Utoguchi,Shinsaku Nakagawa,Tadanori Mayumi, Microvascular Research, Vol. 50, No. 1, p. 129-132, 1995
Ascorbic acid stimulates barrier function of cultured endothelial cell monolayer., Naoki Utoguchi,Kenji Ikeda,Kazuhiko Saeki,Naomi Oka,Hiroyuki Mizuguchi,Kazuyosi Kubo,Shinsaku Nakagawa,Tadanori Mayumi, Journal of Cellular Physiology, Vol. 163, No. 2, p. 393-399, 1995/01/01
GLIAL EXTRACELLULAR-MATRIX MODULATES GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITY IN CULTURED BOVINE BRAIN CAPILLARY AND BOVINE AORTIC ENDOTHELIAL-CELLS, H MIZUGUCHI,Y HASHIOKA,A FUJII,N UTOGUCHI,K KUBO,S NAKAGAWA,A BABA,T MAYUMI, BRAIN RESEARCH, ELSEVIER SCIENCE BV, Vol. 651, No. 1-2, p. 155-159, 1994/07
ジフテリア毒素フラグメントAを封入した細胞膜融合型リポソームのin vivo抗腫よう効果, 水口裕之,中西剛,中川哲彦,久保一義,中川晋作,真弓忠範,中西真人, 日本薬学会年会要旨集, Vol. 114th, No. Pt 4, 1994
A Comparison of Drug Transport through Cultured Monolayers of Bovine Brain Capillary and Bovine Aortic Endothelial Cells, Hiroyuki Mizuguchi,Yuko Hashioka,Naoki Utoguchi,Kazuyoshi Kubo,Shinsaku Nakagawa,Tadanori Mayumi, Biological and Pharmaceutical Bulletin, Vol. 17, No. 10, p. 1385-1390, 1994

Awards

大阪大学総長顕彰, 2015
バイオインダストリー協会賞, 2014
大阪大学総長顕彰, 2014
文部科学大臣表彰科学技術賞（研究部門）, 2014
第6回臨床薬理研究振興財団研究大賞, 2013
大阪大学総長顕彰, 2013
第10回産学官連携功労者表彰（厚生労働大臣賞）, 2012
第4回ﾄﾞｲﾂ･ｲﾉﾍﾞｰｼｮﾝ･ｱﾜｰﾄﾞ「ゴットフリード・ワグネル賞 2012」奨励賞, 2012
大阪大学功績賞, 2011
日本DDS学会永井賞, 2010
日本薬学会奨励賞, 2003
万有薬剤学奨励賞, 2002
日本遺伝子治療学会学会賞, 2001
日本ＭＲＳ－Ｊ学会優秀発表賞, 1996

Profile

Research

Social

Other

Mizuguchi Hiroyuki

Education

Research History

Research Areas

Professional Memberships

Papers

Misc.

Awards