Kamishoyosan Normalizes Dendritic Spine Morphology in the Medial Prefrontal Cortex by Regulating microRNA-18 and Glucocorticoid Receptor Expressions in Postmenopausal Chronic Stress-Exposed Mice.

Shoko Shimizu, Yoshihisa Koyama, Yugo Ishino, Takashi Takeda, Shoichi Shimada, Masaya Tohyama, Shingo Miyata

Cureus　Vol. 16　No. 6　2024/06　Research paper (scientific journal)

Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model

Shogo Togawa, Noriyoshi Usui, Miyuki Doi, Yuki Kobayashi, Yoshihisa Koyama, Yukiko Nakamura, Koh Shinoda, Hikaru Kobayashi, Shoichi Shimada

Behavioural Brain Research　Vol. 468　p. 115040-115040　2024/06　Research paper (scientific journal)

Visualization of Reissner's membrane in the mouse inner ear using highly sensitive magnetic resonance imaging analysis.

Shotaro Harada, Yoshihisa Koyama, Yoshichika Yoshioka, Hidenori Inohara, Shoichi Shimada

Biochemical and biophysical research communications　Vol. 723　p. 150153-150153　2024/05/27　Research paper (scientific journal)

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia.

Tomoo Yuba, Yoshihisa Koyama, Yuki Kinishi, Reiko Uokawa, Chiyo Ootaki, Shoichi Shimada, Yuji Fujino

Reproductive sciences (Thousand Oaks, Calif.)　2024/05/10　Research paper (scientific journal)

A mouse model of autoimmune inner ear disease without endolymphatic hydrops.

Shotaro Harada, Yoshihisa Koyama, Takao Imai, Yoshichika Yoshioka, Takuya Sumi, Hidenori Inohara, Shoichi Shimada

Biochimica et biophysica acta. Molecular basis of disease　Vol. 1870　No. 5　p. 167198-167198　2024/04/25　Research paper (scientific journal)

Si-based agent alleviated small bowel ischemia-reperfusion injury through antioxidant effects.

Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yasunari Matsumoto, Hikaru Kobayashi, Shoichi Shimada

Scientific reports　Vol. 14　No. 1　p. 4141-4141　2024/02/20　Research paper (scientific journal)

Effect of blood sample storage period on d-ROMs and BAP test data

Yuba, T., Koyama, Y., Ootaki, C., Fujino, Y., Shimada, S.

Heliyon　Vol. 10　No. 14　2024　Research paper (scientific journal)

Fever in childbirth: a mini-review of epidural-related maternal fever.

Yuki Kinishi, Yoshihisa Koyama, Tomoo Yuba, Yuji Fujino, Shoichi Shimada

Frontiers in neuroscience　Vol. 18　p. 1389132-1389132　2024　Research paper (scientific journal)

Copper-deficiency is associated with impairments in social behavior and oligodendrocyte development via mTOR signaling pathway

Noriyoshi Usui, Miyuki Doi, Stefano Berto, Kiwamu Matsuoka, Rio Ishida, Koichiro Irie, Nanako Nakama, Hana Miyauchi, Yuuki Fujiwara, Takahira Yamauchi, Takaharu Hirai, Michihiro Toritsuka, Min-Jue Xie, Yoshinori Kayashima, Naoko Umeda, Keiko Iwata, Kazuki Okumura, Taeko Harada, Takeshi Yoshimura, Taiichi Katayama, Masatsugu Tsujii, Hideo Matsuzaki, Manabu Makinodan, Shoichi Shimada

2023/12/18

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

Dan Li, Yoshikazu Johmura, Satoru Morimoto, Miyuki Doi, Keiko Nakanishi, Manabu Ozawa, Yuji Tsunekawa, Akane Inoue-Yamauchi, Hiroya Naruse, Takashi Matsukawa, Yukio Takeshita, Naoki Suzuki, Masashi Aoki, Ayumi Nishiyama, Xin Zeng, Chieko Konishi, Narumi Suzuki, Atsuya Nishiyama, Alexander Stephen Harris, Mariko Morita, Kiyoshi Yamaguchi, Yoichi Furukawa, Kenta Nakai, Shoji Tsuji, Satoshi Yamazaki, Yuji Yamanashi, Shoichi Shimada, Takashi Okada, Hideyuki Okano, Tatsushi Toda, Makoto Nakanishi

Nature Aging　Vol. 3　No. 8　p. 1001-1019　2023/07/20　Research paper (scientific journal)

Histochemical analysis of the biphasic properties of formalin pain-induced behavior.

Ikuei Hirota, Yoshihisa Koyama, Shoichi Shimada

Biochemistry and biophysics reports　Vol. 34　p. 101467-101467　2023/07　Research paper (scientific journal)

Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant.

Yoshihisa Koyama, Yuki Kobayashi, Hikaru Kobayashi, Shoichi Shimada

Antioxidants (Basel, Switzerland)　Vol. 12　No. 5　2023/05/08　Research paper (scientific journal)

Early life stress impairs brain and mental development during childhood increasing the risk of developing psychiatric disorders

Nanako Nakama, Noriyoshi Usui, Miyuki Doi, Shoichi Shimada

Progress in Neuro-Psychopharmacology and Biological Psychiatry　p. 110783-110783　2023/05　Research paper (scientific journal)

Effect of the new silicon-based agent on the symptoms of interstitial pneumonitis.

Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Hikaru Kobayashi, Shoichi Shimada

Scientific reports　Vol. 13　No. 1　p. 5707-5707　2023/04/07　Research paper (scientific journal)

Prenatal Sex Hormone Exposure Is Associated with the Development of Autism Spectrum Disorder

Li, M., Usui, N., Shimada, S.

International Journal of Molecular Sciences　Vol. 24　No. 3　2023/01/22　Research paper (scientific journal)

Irritative Nystagmus Induced by Intratympanic Injection of Potassium Chloride in Mice.,マウスでの鼓室内 KCL 溶液注入による興奮性眼振誘発モデル

Harada, S., Imai, T., Kamakura, T., Inohara, H., Shimada, S.

Equilibrium Research　Vol. 82　No. 6　2023　Research paper (scientific journal)

Localization and potential role of prostate microbiota

Koichi Okada, Kentaro Takezawa, Go Tsujimura, Takahiro Imanaka, Sohei Kuribayashi, Norichika Ueda, Koji Hatano, Shinichiro Fukuhara, Hiroshi Kiuchi, Kazutoshi Fujita, Daisuke Motooka, Shota Nakamura, Yoshihisa Koyama, Shoichi Shimada, Norio Nonomura

Frontiers in Cellular and Infection Microbiology　Vol. 12　2022/12/07　Research paper (scientific journal)

Therapeutic strategy for facial paralysis based on the combined application of Si-based agent and methylcobalamin.

Yoshihisa Koyama, Shotaro Harada, Takashi Sato, Yuki Kobayashi, Hiroto Yanagawa, Toru Iwahashi, Hiroyuki Tanaka, Kazuya Ohata, Takao Imai, Yumi Ohta, Takefumi Kamakura, Hikaru Kobayashi, Hidenori Inohara, Shoichi Shimada

Biochemistry and biophysics reports　Vol. 32　p. 101388-101388　2022/12　Research paper (scientific journal)

The development of a novel antioxidant-based antiemetic drug to improve quality of life during anticancer therapy.

Hiroto Yanagawa, Yoshihisa Koyama, Yuki Kobayashi, Hikaru Kobayashi, Shoichi Shimada

Biochemistry and biophysics reports　Vol. 32　p. 101363-101363　2022/12　Research paper (scientific journal)

Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight

Miyuki Doi, Nanako Nakama, Takuya Sumi, Noriyoshi Usui, Shoichi Shimada

Frontiers in Endocrinology　Vol. 13　2022/10/24　Research paper (scientific journal)

SR 57227A, a serotonin type-3 receptor agonist, as a candidate analgesic agent targeting nociplastic pain.

Yukiko Nakamura, Takuya Sumi, Osamu Mitani, Takashi Okamoto, Erika Kubo, Kuniharu Masui, Makoto Kondo, Yoshihisa Koyama, Noriyoshi Usui, Shoichi Shimada

Biochemical and biophysical research communications　Vol. 622　p. 143-148　2022/07/09　Research paper (scientific journal)

Measurement of intraluminal pH changes in the gastrointestinal tract of mice with gastrointestinal diseases.

Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada

Biochemical and biophysical research communications　Vol. 620　p. 129-134　2022/06/28　Research paper (scientific journal)

A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats.

Yasuhiro Shibata, Natsuko Kumamoto, Eisuke Sakuma, Yusuke Ishida, Takashi Ueda, Shoichi Shimada, Shinya Ugawa

Biochemical and biophysical research communications　Vol. 610　p. 77-84　2022/06/25　Research paper (scientific journal)

Genomic Strategies for Understanding the Pathophysiology of Autism Spectrum Disorder

Miyuki Doi, Mengwei Li, Noriyoshi Usui, Shoichi Shimada

Frontiers in Molecular Neuroscience　Vol. 15　2022/06/24　Research paper (scientific journal)

A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent.

Yoshihisa Koyama, Yuki Kobayashi, Ikuei Hirota, Yuanjie Sun, Iwao Ohtsu, Hiroe Imai, Yoshichika Yoshioka, Hiroto Yanagawa, Takuya Sumi, Hikaru Kobayashi, Shoichi Shimada

Scientific reports　Vol. 12　No. 1　p. 9634-9634　2022/06/10　Research paper (scientific journal)

IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine.

Satoshi Deyama, Makoto Kondo, Shoichi Shimada, Katsuyuki Kaneda

Translational psychiatry　Vol. 12　No. 1　p. 178-178　2022/05/17　Research paper (scientific journal)

Prenatal Environment and Neurodevelopmental Disorders

Miyuki Doi, Noriyoshi Usui, Shoichi Shimada

Frontiers in Endocrinology　Vol. 13　2022/03/15　Research paper (scientific journal)

Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder

Noriyoshi Usui, Xiaoye Tian, Wakana Harigai, Shogo Togawa, Ryo Utsunomiya, Tomomi Doi, Ko Miyoshi, Koh Shinoda, Junya Tanaka, Shoichi Shimada, Taiichi Katayama, Takeshi Yoshimura

Neurochemistry International　Vol. 153　p. 105273-105273　2022/02　Research paper (scientific journal)

Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent.

Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, Shoichi Shimada

Frontiers in psychiatry　Vol. 13　p. 872302-872302　2022　Research paper (scientific journal)

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada

Frontiers in aging neuroscience　Vol. 14　p. 903455-903455　2022　Research paper (scientific journal)

Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders.

Koichiro Irie, Miyuki Doi, Noriyoshi Usui, Shoichi Shimada

Frontiers in neuroscience　Vol. 16　p. 871979-871979　2022　Research paper (scientific journal)

Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex

Shotaro Harada, Takao Imai, Yasumitsu Takimoto, Yumi Ohta, Takashi Sato, Takefumi Kamakura, Noriaki Takeda, Tadashi Kitahara, Makoto Kondo, Yuya Ueno, Shoichi Shimada, Hidenori Inohara

Scientific Reports　Vol. 11　No. 1　p. 17191-17191　2021/12　Research paper (scientific journal)

Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract

Satoshi Aikiyo, Kazuhisa Kishi, Noriyuki Kaji, Shoma Mikawa, Makoto Kondo, Shoichi Shimada, Masatoshi Hori

Digestion　Vol. 102　No. 4　p. 516-526　2021/07/29　Research paper (scientific journal)

Characterization of Early Life Stress-Affected Gut Microbiota

Noriyoshi Usui, Hideo Matsuzaki, Shoichi Shimada

Brain Sciences　Vol. 11　No. 7　p. 913-913　2021/07/10　Research paper (scientific journal)

Correction: Zbtb16 regulates social cognitive behaviors and neocortical development (Translational Psychiatry, (2021), 11, 1, (242), 10.1038/s41398-021-01358-y)

Noriyoshi Usui, Stefano Berto, Ami Konishi, Makoto Kondo, Genevieve Konopka, Hideo Matsuzaki, Shoichi Shimada

Translational Psychiatry　Vol. 11　No. 1　2021/06/01　Research paper (scientific journal)

Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission

Noriyoshi Usui, Shogo Togawa, Takuya Sumi, Yuki Kobayashi, Yoshihisa Koyama, Yukiko Nakamura, Makoto Kondo, Koh Shinoda, Hikaru Kobayashi, Shoichi Shimada

Frontiers in Medical Technology　Vol. 3　2021/05/13　Research paper (scientific journal)

高血糖下Tmem163抑制による膵β細胞障害

下 直樹, 松岡 孝昭, 河盛 段, 宮塚 健, 小山 佳久, 島田 昌一, 下村 伊一郎

糖尿病　Vol. 64　No. Suppl.1　p. I-2　2021/05

Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system

Kazuya Ohata, Makoto Kondo, Yoshiyuki Ozono, Yukiko Hanada, Takashi Sato, Hidenori Inohara, Shoichi Shimada

The FASEB Journal　Vol. 35　No. 5　2021/05　Research paper (scientific journal)

Zbtb16 regulates social cognitive behaviors and neocortical development

Noriyoshi Usui, Stefano Berto, Ami Konishi, Makoto Kondo, Genevieve Konopka, Hideo Matsuzaki, Shoichi Shimada

Translational Psychiatry　Vol. 11　No. 1　2021/04　Research paper (scientific journal)

Internal hydrogen generation and a decrease in oxidative stress by Si-based agent

Yuki Kobayashi, Hikaru Kobayashi, Shoichi Shimada, Ryoichi Imamura

AIP Conference Proceedings　Vol. 2343　2021/03/30　Research paper (international conference proceedings)

Pain-like behavior in mice can be induced by the environmental context in which the pain stimulus was previously given

Yukiko Nakamura, Yukiko Okano, Mizuka Sato, Midori Kobayashi, Takumi Yamaguchi, Takuya Sumi, Yoshihisa Koyama, Makoto Kondo, Noriyoshi Usui, Shoichi Shimada

NeuroReport　2021/02/26　Research paper (scientific journal)

Early Life Stress Alters Gene Expression and Cytoarchitecture in the Prefrontal Cortex Leading to Social Impairment and Increased Anxiety.

Noriyoshi Usui, Yuta Ono, Ryoko Aramaki, Stefano Berto, Genevieve Konopka, Hideo Matsuzaki, Shoichi Shimada

Frontiers in genetics　Vol. 12　p. 754198-754198　2021　Research paper (scientific journal)

Novel BEST1 mutation in autosomal recessive bestrophinopathy in Japanese siblings

Yamada, R., Takagi, R., Iwamoto, S., Shimada, S., Kakehashi, A.

Taiwan Journal of Ophthalmology　Vol. 11　No. 1　p. 71-71　2021　Research paper (scientific journal)

Bladder urothelium converts bacterial lipopolysaccharide information into neural signaling via an ATP-mediated pathway to enhance the micturition reflex for rapid defense

Norichika Ueda, Makoto Kondo, Kentaro Takezawa, Hiroshi Kiuchi, Yosuke Sekii, Yusuke Inagaki, Tetsuji Soda, Shinichiro Fukuhara, Kazutoshi Fujita, Motohide Uemura, Ryoichi Imamura, Yasushi Miyagawa, Norio Nonomura, Shoichi Shimada

Scientific Reports　Vol. 10　No. 1　2020/12　Research paper (scientific journal)

Cartilage and subchondral bone distributions of the distal radius: a 3-dimensional analysis using cadavers.

S Miyamura, K Oka, J Lans, T Sakai, R Shiode, A Kazui, H Tanaka, S Shimada, T Murase

Osteoarthritis and cartilage　Vol. 28　No. 12　p. 1572-1580　2020/08/26　Research paper (scientific journal)

膵β細胞高血糖毒性感受性遺伝子Tmem163の解析

下 直樹, 松岡 孝昭, 河盛 段, 宮塚 健, 小山 佳久, 島田 昌一, 下村 伊一郎

糖尿病　Vol. 63　No. Suppl.1　p. S-236　2020/08

Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo, Hikaru Kobayashi, Norio Nonomura, Shoichi Shimada

Scientific Reports　Vol. 10　No. 1　p. 5859-5859　2020/04　Research paper (scientific journal)

Distinctive expression pattern of Peg10 in the mouse brain

Hisafumi Chikamori, Yusuke Ishida, Yukiko Nakamura, Yoshihisa Koyama, Shoichi Shimada

European Journal of Anatomy　Vol. 23　No. 5　p. 361-368　2019/09/01　Research paper (scientific journal)

Rat model of M?ni?re’s attack: intratympanic injection of potassium chloride produces direction-changing spontaneous nystagmus and hearing fluctuations

Kamakura T, Kitahara T, Kondo M, Horii A, Hanada Y, Takimoto Y, Ishida Y, Nakamura Y, Imai T, Inohara H, Shimada S

Audiology & Neurotology　Vol. 24(5):217-223　No. 5　p. 217-223　2019/09　Research paper (scientific journal)

Cartilage wear patterns in severe osteoarthritis of the trapeziometacarpal joint: a quantitative analysis

S. Miyamura, K. Oka, T. Sakai, H. Tanaka, R. Shiode, S. Shimada, T. Mae, K. Sugamoto, H. Yoshikawa, T. Murase

Osteoarthritis and Cartilage　Vol. 27　No. 8　p. 1152-1162　2019/08　Research paper (scientific journal)

Expression Analysis of Serotonin Receptors, Serotonin Transporter and l-Amino Acid Decarboxylase in the Mouse Sphenopalatine Ganglion by RT-PCR, Northern Blot Analysis and In Situ Hybridization

Ishida, Y., Sugiura, Y., Magome, T., Kamakura, T., Takimoto, Y., Hanada, Y., Kitayama, K., Nakamura, Y., Shimada, S., Ohta, N., Naono-Nakayama, R., Kamijo, K.

Neuroscience　Vol. 411　2019/05　Research paper (scientific journal)

膵β細胞高血糖毒性感受性遺伝子の新規同定と解析

下 直樹, 松岡 孝昭, 河盛 段, 宮塚 健, 小山 佳久, 島田 昌一, 下村 伊一郎

糖尿病　Vol. 62　No. Suppl.1　p. S-121　2019/04

Yokukansan-induced reduction of ethanol preference is associated with antagonism of 5-HT3 receptors

Nakamura, Y., Kondo, M., Koyama, Y., Shimada, S.

Phytomedicine　Vol. 59　2019/03　Research paper (scientific journal)

Regional Distribution of Articular Cartilage Thickness in the Elbow Joint A 3-Dimensional Study in Elderly Humans

Miyamura, S., Sakai, T., Oka, K., Abe, S., Shigi, A., Tanaka, H., Shimada, S., Mae, T., Sugamoto, K., Yoshikawa, H., Murase, T.

JBJS Open Access　Vol. 4　No. 3　p. e0011-e0011　2019　Research paper (scientific journal)

SR 57227A is a partial agonist/partial antagonist of 5-HT3 receptor and inhibits subsequent 5-HT- or SR 57227A-induced 5-HT3 receptor current.

Nakamura Y, Kondo M, Koyama Y, Shimada S

Biochem Biophys Res Commun.　Vol. 508　No. 2　p. 590-596　2019/01　Research paper (scientific journal)

Intravesical ATP instillation induces urinary frequency because of activation of bladder afferent nerves without inflammatory changes in mice: A promising model for overactive bladder

Ueda N, Kondo M, Takezawa K, Kiuchi H, Sekii Y, Inagaki Y, Soda T, Fukuhara S, Fujita K, Uemura M, Imamura R, Miyagawa Y, Nonomura N, Shimada S

Biochem Biophys Res Commun　Vol. 506　No. 3　p. 498-503　2018/11　Research paper (scientific journal)

Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex

Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M

Cerebral Cortex　Vol. 29　No. 9　p. 3738-3751　2018/11　Research paper (scientific journal)

Serotonin 3 receptor signaling regulates 5-fluorouracil-mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells.

Shoma Mikawa, Makoto Kondo, Noriyuki Kaji, Taiki Mihara, Ryohei Yoshitake, Takayuki Nakagawa, Masaya Takamoto, Ryohei Nishimura, Shoichi Shimada, Hiroshi Ozaki, Masatoshi Hori

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 33　No. 2　p. 1669-1680　2018/09　Research paper (scientific journal)

P2X2 receptor deficiency in mouse vestibular end organs attenuates vestibular function

Takimoto Y, Ishida Y, Kondo M, Imai T, Hanada Y, Ozono Y, Kamakura T, Inohara H, Shimada S

Neuroscience　Vol. 386　p. 41-50　2018/08　Research paper (scientific journal)

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and is necessary for auditory and equilibrium function.

Hanada Y, Nakamura Y, Ozono Y, Ishida Y, Takimoto Y, Taniguchi M, Ohata K, Koyama Y, Imai T, Morihana T, Sato T, Inohara H, Shimada S

Scientific Reports　Vol. 8(1) 11491　No. 1　p. 11491-11491　2018/07　Research paper (scientific journal)

BLADDER UROTHELIUM TRIGGERS AN IMMEDIATE DEFENSIVE RESPONSE AGAINST BACTERIAL LIPOPOLYSACCHARIDE VIA ATP SIGNALING

Ueda Norichika, Kondo Makoto, Kiuchi Hiroshi, Inagaki Yusuke, Takezawa Kentaro, Fukuhara Shinichiro, Shimada Shoichi, Nonomura Norio

JOURNAL OF UROLOGY　Vol. 199　No. 4　p. E398-E398　2018/04

Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release.

Yoshinari Obata, Shunbun Kita, Yoshihisa Koyama, Shiro Fukuda, Hiroaki Takeda, Masatomo Takahashi, Yuya Fujishima, Hirofumi Nagao, Shigeki Masuda, Yoshimitsu Tanaka, Yuto Nakamura, Hitoshi Nishizawa, Tohru Funahashi, Barbara Ranscht, Yoshihiro Izumi, Takeshi Bamba, Eiichiro Fukusaki, Rikinari Hanayama, Shoichi Shimada, Norikazu Maeda, Iichiro Shimomura

JCI insight　Vol. 19　No. 3(8)　2018/04　Research paper (scientific journal)

Yokukansan contains compounds that antagonize the 5-HT3 receptor

Yukiko Nakamura, Yusuke Ishida, Makoto Kondo, Shoichi Shimada

Phytomedicine　Vol. 1　No. 43　p. 120-125　2018/04　Research paper (scientific journal)

A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects

M. Kondo, Y. Koyama, Y. Nakamura, S. Shimada

Molecular Psychiatry　Vol. 23　No. 4　p. 833-842　2018/04　Research paper (scientific journal)

Direct modification of the 5-HT₃ receptor current by some anticancer drugs

Nakamura, Y., Ishida, Y., Kondo, M., Shimada, S.

European Journal of Pharmacology　Vol. 821　No. 821　p. 21-28　2018/02　Research paper (scientific journal)

Wnt経路に基づいた老年性内耳障害の解明

花田有紀子, 滝本泰光, 森鼻哲生, 佐藤崇, 今井貴夫, 中村雪子, 島田昌一, 猪原秀典

耳鼻咽喉科ニューロサイエンス　Vol. 31　p. 22-24　2017/11　Research paper (scientific journal)

Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing.

Yukiko Hanada, Yukiko Nakamura, Yusuke Ishida, Yasumitsu Takimoto, Manabu Taniguchi, Yoshiyuki Ozono, Yoshihisa Koyama, Tetsuo Morihana, Takao Imai, Yumi Ota, Takashi Sato, Hidenori Inohara, Shoichi Shimada

Biochem Biophys Res Commun　Vol. 492　No. 3　p. 379-385　2017/08　Research paper (scientific journal)

The significance of complete distributional analysis of the serotonin receptor

Koyama Y, Kondo M, Shimada S

Neurotransmitter　Vol. 4: e1564　2017/06

THE ROLE OF UROTHELIAL ATP SIGNALING IN MICTURITION REFLEX

Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Norichika Ueda, Tetsuji Soda, Shinichiro Fukuhara, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Kazumasa Matsumoto-Miyai, Yusuke Ishida, Hiromitsu Negoro, Shoichi Shimada, Norio Nonomura

JOURNAL OF UROLOGY　Vol. 197　No. 4　p. E1351-E1352　2017/04

Urothelial ATP signaling: what is its role in bladder sensation?

Kentaro Takezawa, Makoto Kondo, Norio Nonomura, Shoichi Shimada

NEUROUROLOGY AND URODYNAMICS　Vol. 36　No. 4　p. 966-972　2017/04

Building a 5-HT3A Receptor Expression Map in the Mouse Brain

Yoshihisa Koyama, Makoto Kondo, Shoichi Shimada

SCIENTIFIC REPORTS　Vol. 7　2017/03　Research paper (scientific journal)

Cisplatin-induced toxicity decreases the mouse vestibulo-ocular reflex

Yasumitsu Takimoto, Takao Imai, Makoto Kondo, Yukiko Hanada, Atsuhiko Uno, Yusuke Ishida, Takefumi Kamakura, Tadashi Kitahara, Hidenori Inohara, Shoichi Shimada

TOXICOLOGY LETTERS　Vol. 262　p. 49-54　2016/11　Research paper (scientific journal)

Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia

Takefumi Kamakura, Makoto Kondo, Yoshihisa Koyama, Yukiko Hanada, Yusuke Ishida, Yukiko Nakamura, Takahiro Yamada, Yasumitsu Takimoto, Tadashi Kitahara, Yoshiyuki Ozono, Arata Horii, Takao Imai, Hidenori Inohara, Shoichi Shimada

AUDIOLOGY AND NEURO-OTOLOGY　Vol. 21　No. 4　p. 268-274　2016/10　Research paper (scientific journal)

High-Speed Video-Oculography for Measuring Three-Dimensional Rotation Vectors of Eye Movements in Mice

Takao Imai, Yasumitsu Takimoto, Noriaki Takeda, Atsuhiko Uno, Hidenori Inohara, Shoichi Shimada

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

Authentic role of ATP signaling in micturition reflex

Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Norichika Ueda, Tetsuji Soda, Shinichiro Fukuhara, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Kazumasa Matsumoto-Miyai, Yusuke Ishida, Hiromitsu Negoro, Osamu Ogawa, Norio Nonomura, Shoichi Shimada

SCIENTIFIC REPORTS　Vol. 6　2016/01　Research paper (scientific journal)

The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects

M. Kondo, Y. Nakamura, Y. Ishida, S. Shimada

MOLECULAR PSYCHIATRY　Vol. 20　No. 11　p. 1428-1437　2015/11　Research paper (scientific journal)

Serotonergic regulation of distention-induced ATP release from the urothelium

Kazumasa Matsumoto-Miyai, Erika Yamada, Eriko Shinzawa, Yoshihisa Koyama, Shoichi Shimada, Masaru Yoshizumi, Masahito Kawatani

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 310　No. 7　p. F646-F655　2015/11　Research paper (scientific journal)

Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons.

Watanabe M, Ueda T, Shibata Y, Kumamoto N, Shimada S, Ugawa S

PLoS One　Vol. 14　No. 10　2015/05　Research paper (scientific journal)

アディポネクチン蛋白の動脈における局在変化の解析

前田 法一, 森 卓也, 小山 佳之, 中村 雪子, 藤島 裕也, 松田 圭介, 船橋 徹, 島田 昌一, 下村 伊一郎

日本内分泌学会雑誌　Vol. 91　No. 1　p. 334-334　2015/04

Serotonin and exercise-induced brain plasticity.

Kondo M, Shimada S

Neurotransmitter　Vol. 2　2015/04　Research paper (scientific journal)

Exercise-induced neuronal effects and the 5-HT3 receptor.

Kondo M, Shimada S

Neurotransmitter　Vol. 2　2015/04　Research paper (scientific journal)

A NEW MECHANISM OF INFECTION-INDUCED BLADDER HYPERACTIVITY: LIPOPOLYSACCHARIDE CAUSES RAPID ATP RELEASE FROM UROTHELIUM AND STIMULATES THE MECHANOSENSORY AFFERENT PATHWAY

Takezawa Kentaro, Kondo Makoto, Kiuchi Hiroshi, Soda Tetsuji, Fukuhara Shinichiro, Takao Tetsuya, Miyagawa Yasushi, Tsujimura Akira, Matsumoto-Miyai Kazumasa, Shimada Shoichi, Nonomura Norio

JOURNAL OF UROLOGY　Vol. 193　No. 4　p. E80-E80　2015/04

Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in post-operative ileus

Toko Maehara, Kenjiro Matsumoto, Kazuhide Horiguchi, Makoto Kondo, Satoshi Iino, Shunji Horie, Takahisa Murata, Hirokazu Tsubone, Shoichi Shimada, Hiroshi Ozaki, Masatoshi Hori

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 4　p. 1136-47　2015/02　Research paper (scientific journal)

動脈血管におけるアディポネクチンの局在解析

森 卓也, 小林 佳之, 前田 法一, 中村 雪子, 藤島 裕也, 松田 圭介, 船橋 徹, 島田 昌一, 下村 伊一郎

肥満研究　Vol. 20　No. Suppl.　p. 181-181　2014/10

Combination of bladder ultrasonography and novel cystometry method in mice reveals rapid decrease in bladder capacity and compliance in LPS-induced cystitis

Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Shoichi Shimada

American Journal of Physiology - Renal Physiology　Vol. 307　No. 2　p. F234-F241　2014/07　Research paper (scientific journal)

Combination of bladder ultrasonography and novel cystometry method in mice reveals rapid decrease in bladder capacity and compliance in LPS-induced cystitis

Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Shoichi Shimada

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 307　No. 2　p. F234-F241　2014/07　Research paper (scientific journal)

Ultrastructural Localization of Adiponectin protein in Vasculature of Normal and Atherosclerotic mice

Takuya Mori, Yoshihisa Koyama, Norikazu Maeda, Yukiko Nakamura, Yuya Fujishima, Keisuke Matsuda, Tohru Funahashi, Shoichi Shimada, Iichiro Shimomura

SCIENTIFIC REPORTS　Vol. 4　2014/05　Research paper (scientific journal)

5-HT(3) receptor expression in the mouse vestibular ganglion.

Takimoto Y, Ishida Y, Nakamura Y, Kamakura T, Yamada T, Kondo M, Kitahara T, Uno A, Imai T, Horii A, Okazaki S, Nishiike S, Inohara H, Shimada S

Brain Research　Vol. 1557　p. 74-82　2014/04　Research paper (scientific journal)

5-hydroxytryptamine type-3A receptor in the process of fear extinction

Kondo M, Shimada S

Receptors & Clinical Investigation　Vol. 1: e71　2014/02

The 5-HT3A receptor is essential for fear extinction

Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Shoichi Shimada

Learning and Memory　Vol. 21　No. 1　p. 1-4　2013/12　Research paper (scientific journal)

Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia

Takefumi Kamakura, Yusuke Ishida, Yukiko Nakamura, Takahiro Yamada, Tadashi Kitahara, Yasumitsu Takimoto, Arata Horii, Atsuhiko Uno, Takao Imai, Suzuyo Okazaki, Hidenori Inohara, Shoichi Shimada

NEUROSCIENCE LETTERS　Vol. 552　p. 92-97　2013/09　Research paper (scientific journal)

Kamakura T, Ishida Y, Nakamura Y, Yamada T, Kitahara T, Takimoto Y, Horii A, Uno A, Imai T, Okazaki S, Inohara H, Shimada S

Functional expression of TRPV, d TRPA, in rat vestibular ganglia

Vol. 25　No. 552　p. 92-97　2013/09　Research paper (scientific journal)

前庭神経節におけるTRPV1、TRPA1受容体の発現について

鎌倉武史, 石田雄介, 中村雪子, 山田貴博, 北原糺, 滝本泰光, 堀井新, 宇野敦彦, 今井貴夫, 岡崎鈴代, 猪原秀典, 島田昌一

耳鼻咽喉科ニューロサイエンス　Vol. 27　2013/08　Research paper (scientific journal)

前庭神経節におけるTRPV1、TRPA1受容体の発現について

鎌倉武史, 石田雄介, 中村雪子, 山田貴博, 北原糺, 滝本泰光, 堀井新, 宇野敦彦, 今井貴夫, 岡崎鈴代, 猪原秀典, 島田昌一

耳鼻咽喉科ニューロサイエンス　Vol. 27　p. 58-61　2013/04　Research paper (scientific journal)

Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan

Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Makoto Kondo, Shoichi Shimada

JOURNAL OF NEUROCHEMISTRY　Vol. 125　No. 1　p. 7-15　2013/04　Research paper (scientific journal)

Possible implications of acid-sensing ion channels in ischemia-induced retinal injury in rats.

Miyake T, Nishiwaki A, Yasukawa T, Ugawa S, Shimada S, Ogura Y

Jpn J Ophthalmol.　Vol. 57　No. 1　p. 120-125　2013/01　Research paper (scientific journal)

Corrigendum to "TRPV3, a thermosensitive channel is expressed in mouse distal colon epithelium" [Biochem. Biophys. Res. Commun. 383 (2009) 130-134]

Takashi Ueda, Takahiro Yamada, Shinya Ugawa, Yusuke Ishida, Shoichi Shimada

Biochemical and Biophysical Research Communications　Vol. 426　No. 4　2012/10/05　Research paper (scientific journal)

ASICsについて何がわかっているか

島田昌一, 石田雄介, 中村雪子, 山田貴博, 植田高史, 鵜川眞也

分子消化器病　2011/12

Geissoschizine methyl ether has third-generation antipsychotic-like actions at the dopamine and serotonin receptors.

Ueda T, Ugawa S, Ishida Y, Shimada S

Eur J Pharmacol　Vol. 671　No. 1-3　p. 79-86　2011/12　Research paper (scientific journal)

Acid inhibits TRPV4-mediated Ca(2+) influx in mouse esophageal epithelial cells

M. Shikano, T. Ueda, T. Kamiya, Y. Ishida, T. Yamada, T. Mizushima, T. Shimura, T. Mizoshita, S. Tanida, H. Kataoka, S. Shimada, S. Ugawa, T. Joh

NEUROGASTROENTEROLOGY AND MOTILITY　Vol. 23　No. 11　p. 1020-E497　2011/11　Research paper (scientific journal)

Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responses

Yukiko Nakamura, Yusuke Ishida, Takahiro Yamada, Shoichi Shimada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 415　No. 2　p. 416-420　2011/11　Research paper (scientific journal)

Bile-acid-induced calcium signaling in mouse esophageal epithelial cells

Takahiro Yamada, Yusuke Ishida, Yukiko Nakamura, Shoichi Shimada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 414　No. 4　p. 789-794　2011/11　Research paper (scientific journal)

Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.

Kishimoto K, Nishizuka M, Ueda T, Kajita K, Ugawa S, Shimada S, Osada S, Imagawa M

EXPERIMENTAL CELL RESEARCH　Vol. 317　No. 15　p. 2110-2123　2011/09　Research paper (scientific journal)

TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats.

Shibata Y, Ugawa S, Imura M, Kubota Y, Ueda T, Kojima Y, Ishida Y, Sasaki S, Hayashi Y, Kohri K, Shimada S

Neuroreport　Vol. 22　No. 2　p. 61-67　2011/01　Research paper (scientific journal)

TRPV2 Activation Induces Apoptotic Cell Death in Human T24 Bladder Cancer Cells: A Potential Therapeutic Target for Bladder Cancer

Takahiro Yamada, Takashi Ueda, Yasuhiro Shibata, Yosuke Ikegami, Masaki Saito, Yusuke Ishida, Shinya Ugawa, Kenjiro Kohri, Shoichi Shimada

UROLOGY　Vol. 76　No. 2　2010/08　Research paper (scientific journal)

Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex

Aki Hondoh, Yusuke Ishida, Shinya Ugawa, Takashi Ueda, Yasuhiro Shibata, Takahiro Yamada, Michiko Shikano, Shingo Murakami, Shoichi Shimada

BRAIN RESEARCH　Vol. 1319　p. 60-69　2010/03　Research paper (scientific journal)

Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro

Kazuhiro Yagita, Kyoji Horie, Satoshi Koinuma, Wataru Nakamura, Iori Yamanaka, Akihiro Urasaki, Yasufumi Shigeyoshi, Koichi Kawakami, Shoichi Shimada, Junji Takeda, Yasuo Uchiyama

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 8　p. 3846-3851　2010/02　Research paper (scientific journal)

Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex

Yusuke Ishida, Aki Hondoh, Shinya Ugawa, Takashi Ueda, Takahiro Yamada, Shoichi Shimada

NEUROSCIENCE RESEARCH　Vol. 68　p. E280-E280　2010　Research paper (scientific journal)

Real-time monitoring of circadian clock oscillations in primary cultures of mammalian cells using Tol2 transposon-mediated gene transfer strategy.

Yagita K, Yamanaka I, Emoto N, Kawakami K, Shimada S

BMC Biotechnol　Vol. 10　2010/01　Research paper (scientific journal)

Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.

Yamada T, Ueda T, Ugawa S, Ishida Y, Imayasu M, Koyama S, Shimada S

Exp Eye Res　Vol. 90　No. 1　p. 121-129　2010/01　Research paper (scientific journal)

Fad24 causes hyperplasia in adipose tissue and improves glucose metabolism.

Johmura Y, Watanabe K, Kishimoto K, Ueda T, Shimada S, Osada S, Nishizuka M, Imagawa M

Pharm Bull　Vol. 32　No. 10　p. 1656-1664　2009/10　Research paper (scientific journal)

Development of generic calcium imaging assay for monitoring Gi-coupled receptors and G-protein interaction.

Ueda T, Ugawa S, Ishida Y, Hondoh A, Shimada S

J Biomol Screen　Vol. 14　No. 7　p. 781-788　2009/08　Research paper (scientific journal)

TRPV3, a thermosensitive channel is expressed in mouse distal colon epithelium.

Ueda T, Yamada T, Ugawa S, Ishida Y, Shimada S

Biochem Biophys Res Commun　Vol. 383　No. 1　p. 130-134　2009/05　Research paper (scientific journal)

P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice.

Ishida Y, Ugawa S, Ueda T, Yamada T, Shibata Y, Hondoh A, Inoue K, Yu Y, Shimada S

J Comp Neurol　Vol. 514　No. 2　p. 131-144　2009/05　Research paper (scientific journal)

Differential Localizations of the Transient Receptor Potential Channels TRPV4 and TRPV1 in the Mouse Urinary Bladder

Takahiro Yamada, Shinya Ugawa, Takashi Ueda, Yusuke Ishida, Kenji Kajita, Shoichi Shimada

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY　Vol. 57　No. 3　p. 277-287　2009/03　Research paper (scientific journal)

Effects of multipurpose contact-lens care solutions on adhesion of Pseudomonas aeruginosa to corneal epithelial cells.

Imayasu M, Shimizu H, Shimada S, Suzuki T, Cavanagh HD

Eye Contact Lens　Vol. 35　No. 2　p. 98-104　2009/03　Research paper (scientific journal)

Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder.

Yamada T, Ugawa S, Ueda T, Ishida Y, Kajita K, Shimada S

J Histochem Cytochem　Vol. 57　No. 3　p. 277-287　2009/03　Research paper (scientific journal)

Upregulation of the P2X7 receptor after cryogenic injury to rat brain.

Yu Y, Ishida Y, Ugawa S, Ueda T, Oka Y, Yamada K, Shimada S

Neuroreport　Vol. 20　No. 4　p. 393-397　2009/03　Research paper (scientific journal)

Reelin-Disabled1 signaling in the mature rat cochlear nucleus

Akira Inagaki, Shinya Ugawa, Majid M. Safwat, Sumru Keceli, Shoichi Shimada, Suzuki Motohiko, Shingo Murakami

ACTA OTO-LARYNGOLOGICA　Vol. 129　p. 7-11　2009　Research paper (scientific journal)

Epithelial Na+ channel delta subunit is an acid sensor in the human oesophagus.

Yamamura H, Ugawa S, Ueda T, Nagao M, Joh T, Shimada S

Eur J Pharmacol　Vol. 600　No. 1-3　p. 32-36　2008/12　Research paper (scientific journal)

Topical apolipoprotein A-1 may have a beneficial effect on the corneal epithelium in a mouse model of dry eye: a pilot study.

Nyunt AK, Ishida Y, Yu Y, Shimada S

Eye Contact Lens　Vol. 34　No. 5　p. 287-292　2008/09　Research paper (scientific journal)

Epithelial Na+ channel delta subunit mediates acid-induced ATP release in the human skin.

Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S

Biochem Biophys Res Commun　Vol. 373　No. 1　p. 155-158　2008/08　Research paper (scientific journal)

TRPM8 activation suppresses cellular viability in human melanoma.

Yamamura H, Ugawa S, Ueda T, Morita A, Shimada S

Am J Physiol Cell Physiol　Vol. 295　No. 2　p. C296-C301　2008/08　Research paper (scientific journal)

Hypotonic stimuli enhance proton-gated currents of acid-sensing ion channel-1b.

Ugawa S, Ishida Y, Ueda T, Yu Y, Shimada S

Biochem Biophys Res Commun　Vol. 367　No. 3　p. 530-534　2008/03　Research paper (scientific journal)

The CaV3.1 T-type Ca2+channel contributes to voltage-dependent calcium currents in rat outer hair cells.

Inagaki A, Ugawa S, Yamamura H, Murakami S, Shimada S

Brain Res　Vol. 1201　p. 68-77　2008/03　Research paper (scientific journal)

Expression analysis of the epithelial Na+ channel delta subunit in human melanoma G-361 cells.

Yamamura H, Ugawa S, Ueda T, Shimada S

Biochem Biophys Res Commun　Vol. 366　No. 2　p. 489-492　2008/02　Research paper (scientific journal)

Cellular localization of P2X7 receptor mRNA in the rat brain.

Yu Y, Ugawa S, Ueda T, Ishida Y, Inoue K, Kyaw Nyunt A, Umemura A, Mase M, Yamada K, Shimada S

Brain Res　Vol. 1194　p. 45-55　2008/02　Research paper (scientific journal)

Evidence for P2X7 mRNA distribution in the rat brain using RI in situ hybridization

Yong Yu, Shinya Ugawa, Takashi Ueda, Yusuke Ishida, Kiyoshi Inoue, Aung Kyaw Nyunt, Atsushi Umemura, Mitsuhito Mase, Kazuo Yamada, Shoichi Shimada

NEUROSCIENCE RESEARCH　Vol. 61　p. S223-S223　2008

Hypotonic stimuli enhance proton-gated currents of acid-sensing ion channel-1b

Shinya Ugawa, Yusuke Ishida, Takashi Ueda, Shoichi Shimada

NEUROSCIENCE RESEARCH　Vol. 61　p. S247-S247　2008　Research paper (scientific journal)

Effects of multipurpose solutions on corneal epithelial tight junctions.

Imayasu M, Shiraishi A, Ohashi Y, Shimada S, Cavanagh HD

Eye Contact Lens　Vol. 34　No. 1　p. 50-55　2008/01　Research paper (scientific journal)

Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.

Ugawa S, Ishida Y, Ueda T, Inoue K, Nagao M, Shimada S

Biochem Biophys Res Commun　Vol. 363　No. 1　p. 203-208　2007/11　Research paper (scientific journal)

Activation of sensory neurons contributes to reduce spinal cord injury in rats.

Kitamura T, Harada N, Goto E, Tanaka K, Arai M, Shimada S, Okajima K

Neuropharmacology　Vol. 52　No. 2　p. 506-514　2007/02　Research paper (scientific journal)

Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice.

Shimozawa N, Okajima K, Harada N, Arai M, Ishida Y, Shimada S, Kurihara H, Nakagata N

Gastroenterology　Vol. 131　No. 6　p. 1826-1834　2006/12　Research paper (scientific journal)

A novel spliced variant of the epithelial Na+ channel delta-subunit in the human brain.

Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S

Biochem Biophys Res Commun　Vol. 349　No. 1　p. 317-321　2006/10　Research paper (scientific journal)

Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells.

Ugawa S, Inagaki A, Yamamura H, Ueda T, Ishida Y, Kajita K, Shimizu H, Shimada S

Neuroreport　Vol. 17　No. 12　p. 1235-9　2006/08　Research paper (scientific journal)

14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.

Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T, Ichimura T

Biochemistry　Vol. 45　No. 21　p. 6733-6740　2006/05　Research paper (scientific journal)

Evans blue is a specific antagonist of the human epithelial Na+ channel delta-subunit.

Yamamura H, Ugawa S, Ueda T, Shimada S

J Pharmacol Exp Ther　Vol. 315　No. 2　p. 965-969　2005/11　Research paper (scientific journal)

Icilin activates the delta-subunit of the human epithelial Na+ channel.

Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S

Mol Pharmacol　Vol. 68　No. 4　p. 1142-1147　2005/10　Research paper (scientific journal)

内耳におけるメガリンの発現と定量化

稲垣 彰, 矢野 陽子, 村上 信五, 鵜川 眞也, 植田 高史, 山村 寿男, 島田 昌一

日本耳鼻咽喉科学会会報　Vol. 108　No. 5増刊　p. 582-583　2005/05

In situ hybridization evidence for the coexistence of ASIC and TRPV1 within rat single sensory neurons.

Ugawa S, Ueda T, Yamamura H, Shimada S

Mol Brain Res　Vol. 136　No. 1　p. 125-133　2005/05　Research paper (scientific journal)

Histopathologic evaluation of the internal limiting membrane surgically excised from eyes with diabetic maculopathy.

Matsunaga N, Ozeki H, Hirabayashi Y, Shimada S, Ogura Y

Retina　Vol. 25　No. 3　p. 311-316　2005/04　Research paper (scientific journal)

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T

J Biol Chem　Vol. 280　No. 13　p. 13187-13194　2005/04　Research paper (scientific journal)

Effect of benzalkonium chloride on transscleral drug delivery.

Okabe K, Kimura H, Okabe J, Kato A, Shimizu H, Ueda T, Shimada S, Ogura Y

Invest Ophthalmol Vis Sci　Vol. 46　No. 2　p. 703-708　2005/02　Research paper (scientific journal)

Functional interaction between TAS2R receptors and G-protein alpha subunits expressed in taste receptor cells

T Ueda, S Ugawa, S Shimada

CHEMICAL SENSES　Vol. 30　p. I16-I16　2005/01　Research paper (scientific journal)

Coexpression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons

S Ugawa, T Ueda, H Yamamura, M Nagao, S Shimada

CHEMICAL SENSES　Vol. 30　p. I195-I195　2005/01　Research paper (scientific journal)

Capsazepine Is a Novel Activator of the {delta} Subunit of the Human Epithelial Na+ Channel.

Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S

J Biol Chem　Vol. 279　No. 43　p. 44483-44489　2004/10　Research paper (scientific journal)

Functional analysis of acid sensing ion channels

Shoichi Shimada, Hisao Yamamura, Takashi Ueda, Takashi Yamamoto, Shinya Ugawa

Japanese Journal of Neuropsychopharmacology　Vol. 24　No. 4　p. 243-246　2004/08

Protons activate the delta-subunit of the epithelial Na+ channel in humans.

Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S

J Biol Chem　Vol. 279　No. 13　p. 12529-12534　2004/03　Research paper (scientific journal)

Protons activate the delta-subunit of the epithelial Na+ channel in humans

H Yamamura, S Ugawa, T Ueda, M Nagao, S Shimada

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 94　p. 108P-108P　2004　Research paper (scientific journal)

Upregulation of P-selectin and intercellular adhesion molecule-1 after retinal ischemia-reperfusion injury.

Nishiwaki A, Ueda T, Ugawa S, Shimada S, Ogura Y

Invest Ophthalmol Vis Sci　Vol. 44　No. 11　p. 4931-4935　2003/11　Research paper (scientific journal)

Phosphorylation of MAP kinase in corneal epithelial cells during wound healing.

Imayasu M, Shimada S

Curr Eye Res　Vol. 27　No. 3　p. 133-141　2003/09　Research paper (scientific journal)

Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells.

Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S

J Neurosci　Vol. 23　No. 19　p. 7376-7380　2003/08　Research paper (scientific journal)

Amiloride-insensitive currents of the ASIC2a/ASIC2b heteromeric sour-taste receptor channel.

Ugawa S, Yamamoto T, Ueda T, Ishida Y, Inagaki A, Nishigaki M, Shimada S

J Neurosci　Vol. 23　No. 9　p. 3616-22　2003/05　Research paper (scientific journal)

Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice.

El-Malky M, Maruyama H, Hirabayashi Y, Shimada S, Yoshida A, Amano T, Tominaga A, Takatsu K, Ohta N

Parasitol Int　Vol. 52　No. 1　p. 71-79　2003/03　Research paper (scientific journal)

Subarachnoid hemorrhage induces Na⁺/myo-inositol cotransporter in the rat brain

Kimura, T., Yamada, K., Masago, A., Shimada, S.

Neurologia Medico-Chirurgica　Vol. 43　No. 2　2003　Research paper (scientific journal)

A novel putative M9.2 isoform of V-ATPase expressed in the nervous system.

Ueda T, Ugawa S, Shimada S

Neuroreport　Vol. 14　No. 1　p. 25-30　2003/01　Research paper (scientific journal)

Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae.

Ishida Y, Ugawa S, Ueda T, Murakami S, Shimada S

Mol Brain Res　Vol. 107　No. 1　p. 17-22　2002/10　Research paper (scientific journal)

Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.

Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S

J Clin Invest　Vol. 110　No. 8　p. 1185-1190　2002/10　Research paper (scientific journal)

Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain.

Aihara N, Imamura N, Kimura T, Yamada K, Hida H, Nishino H, Ueda T, Shimada S

Neurosci Lett　Vol. 327　No. 1　p. 21-24　2002/07　Research paper (scientific journal)

ラット線条体出血後に黒質は萎縮し,Na+/myo-inositol cotransporter陽性のmicrogliaが集積している

相原 徳孝, 今村 暢紀, 木村 知寛, 山田 和雄, 飛田 秀樹, 西野 仁雄, 島田 昌一

神経組織の成長・再生・移植研究会学術集会プログラム・予稿集　Vol. 17回　p. 42-42　2002/06

Enhanced expression of adhesion molecules of the retinal vascular endothelium in spontaneous diabetic rats.

Nozaki M, Ogura Y, Hirabayashi Y, Saishin Y, Shimada S

Ophthalmic Res　Vol. 34　No. 3　p. 158-164　2002/05　Research paper (scientific journal)

Strongyloides venezuelensis: longitudinal distribution of adult worms in the host intestine is influenced by mucosal sulfated carbohydrates.

Maruyama H, Hirabayashi Y, el-Malky M, Okamura S, Aoki M, Itagaki T, Nakamura-Uchiyama F, Nawa Y, Shimada S, Ohta N

Exp Parasitol　Vol. 100　No. 3　p. 179-185　2002/03　Research paper (scientific journal)

Expression of glia maturation factor during retinal development in the rat.

Nishiwaki A, Asai K, Tada T, Ueda T, Shimada S, Ogura Y, Kato T

Mol Brain Res　Vol. 95　No. 1-2　p. 103-109　2001/11　Research paper (scientific journal)

Cloning and functional expression of ASIC-beta 2, a splice variant of ASIC-beta

S Ugawa, T Ueda, E Takahashi, Y Hirabayashi, T Yoneda, S Komai, S Shimada

NEUROREPORT　Vol. 12　No. 13　p. 2865-2869　2001/09　Research paper (scientific journal)

Cloning and functional expression of ASIC-b2, a splice variant of ASIC-b, that alters pH-sensitivity of acid-sensing ion channel complex.

Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, Shimada S

Neuroreport　Vol. 12, 2865-2869.　2001/09　Research paper (scientific journal)

Expression of receptor-activity modifying protein (RAMPs) mRNAs in the mouse brain.

Ueda T, Ugawa S, Saishin Y, Shimada S

Mol Brain Res　Vol. 93　No. 1　p. 36-45　2001/09　Research paper (scientific journal)

Characterization of a mouse colonic system B0+ amino acid transporter related to amino acid absorption in colon

S Ugawa, Y Sunouchi, T Ueda, E Takahashi, Y Saishin, S Shimada

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 281　No. 2　p. G365-G370　2001/08　Research paper (scientific journal)

Cloning of a mouse colonic system B 0+ amino acid transporter related to amino acid absorption in the colon.

Ugawa S, Sunouchi Y, Ueda T, Takahashi E, Saishin Y, Shimada S

Am J Physiol　Vol. 281, G365-370.　2001/08　Research paper (scientific journal)

Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting.

Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S

Biochem Biophys Res Commun　Vol. 285　No. 1　p. 147-151　2001/07　Research paper (scientific journal)

A single amino acid substitution in MDEG2 speciffically alters desensitization of the proton-activated cation current.

Ugawa S, Ueda T, Minami Y, Horimoto M, Shimada S

Neororeport　Vol. 12　No. 10　p. 2141-2145　2001/07　Research paper (scientific journal)

Cloning of a lymphatic peptide/histidine transporter.

Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M

Biochem J　Vol. 356　p. 53-60　2001/05　Research paper (scientific journal)

Electron microscopic cytochemical studies of anionic sites in the rat spleen.

Ueda H, Takehana K, Eerdunchaolu, Iwasa K, Fujimori O, Shimada S

J Vet Med Sci　Vol. 63　No. 3　p. 287-291　2001/03　Research paper (scientific journal)

Suppression of lens stalk cell apoptosis by hyaluronic acid leads to faulty separation of the lens vesicle.

Ozeki H, Ogura Y, Hirabayashi Y, Shimada S

Exp Eye Res　Vol. 72　No. 1　p. 63-70　2001/01　Research paper (scientific journal)

Diffuse brain injury induces local expression of Na(+)/myo-inositol cotransporter in the rat brain.

Ueda T, Iwata A, Komatsu H, Aihara N, Yamada K, Ugawa S, Shimada S

Mol Brain Res　Vol. 86　No. 1-2　p. 63-69　2001/01　Research paper (scientific journal)

A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer.

Horimoto M, Sasaki Y, Ugawa S, Wada S, Toyama T, Iyoda K, Yakushijin T, Minami Y, Ito T, Hijioka T, Eguchi A, Nakanishi M, Shimada S, Tohyama M, Hayashi N, Hori M

Cancer Gene Ther　Vol. 7　No. 10　p. 1341-1347　2000/10　Research paper (scientific journal)

Retinal fascin: functional nature, subcellular distribution, and chromosomal localization.

Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, Kohama K, Shimizu H, Tano Y, Shimada S

Invest Ophthalmol Vis Sci　Vol. 41　No. 8　p. 2087-2095　2000/07　Research paper (scientific journal)

Apoptosis is associated with formation and persistence of the embryonic fissure.

Ozeki H, Ogura Y, Hirabayashi Y, Shimada S

Curr Eye Res　Vol. 20　No. 5　p. 367-372　2000/05　Research paper (scientific journal)

Genes for Taste Receptors; Isolation of a Gene for a Sour Taste Receptor

UGAWA Shinya, SHIMADA Shoichi

Seibutsu Butsuri　Vol. 40　No. 2　p. 105-110　2000/03/25

Histochemical studies on glycosaminoglycans in bruch's membrane of postnatal rat eyes

Yoshifumi Hirabayashi, Toshihisa Fujii, Kozo Ikeda, Hironori Ozeki, Shinya Ugawa, Shoichi Shimada

Acta Anatomica Nipponica　Vol. 75　No. 4　p. 337-343　2000　Research paper (scientific journal)

Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion.

Nishimura M, Sato K, Shimada S, Tohyama M

Mol Brain Res　Vol. 67　No. 1　p. 82-86　1999/04　Research paper (scientific journal)

Comparison between the decrease of dopamine transporter and that of L-DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal models.

Ito Y, Fujita M, Shimada S, Watanabe Y, Okada T, Kusuoka H, Tohyama M, Nishimura T

Synapse　Vol. 31　No. 3　p. 178-185　1999/03　Research paper (scientific journal)

Cloning of a bovine orphan transporter and its short splicing variant.

Sakata K, Shimada S, Yamashita T, Inoue K, Tohyama M

FEBS Lett　Vol. 443　No. 3　p. 267-270　1999/01　Research paper (scientific journal)

Molecular cloning and characterization of rat trp homologues from brain.

Mizuno N, Kitayama S, Saishin Y, Shimada S, Morita K, Mitsuhata C, Kurihara H, Dohi T

Mol Brain Res　Vol. 64　No. 1　p. 41-51　1999/01　Research paper (scientific journal)

Receptor that leaves a sour taste in the mouth.

Ugawa S, Minami Y, Guo W, Saishin Y, Takatsuji K, Yamamoto T, Tohyama M, Shimada S

Nature　Vol. 395　No. 6702　p. 555-556　1998/10　Research paper (scientific journal)

Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure (vol 55, pg 54, 1998)

M Nonaka, E Kohmura, T Yamashita, S Shimada, K Tanaka, T Yoshimine, M Tohyama, T Hayakawa

MOLECULAR BRAIN RESEARCH　Vol. 60　No. 2　p. 310-310　1998/10　Research paper (scientific journal)

Re: Kitamura et al: "Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat"

S Rosen, H Bits, D Darmon, M Brezis, S Heyman

KIDNEY INTERNATIONAL　Vol. 54　No. 1　p. 301-302　1998/07　Research paper (scientific journal)

Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure.

Nonaka M, Kohmura E, Yamashita T, Shimada S, Tanaka K, Yoshimine T, Tohyama M, Hayakawa T

Mol Brain Res　Vol. 55　No. 1　p. 54-60　1998/03　Research paper (scientific journal)

Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293 cells.

Nishimura M, Sato K, Okada T, Yoshiya I, Schloss P, Shimada S, Tohyama M

Anesthesiology　Vol. 88　No. 3　p. 768-774　1998/03　Research paper (scientific journal)

MK-801 blocks monoamine transporters expressed in HEK cells.

Nishimura M, Sato K, Okada T, Schloss P, Shimada S, Tohyama M

423, 376-380.　Vol. 423　No. 3　p. 376-380　1998/02　Research paper (scientific journal)

Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat.

Kitamura H, Yamauchi A, Sugiura T, Matsuoka Y, Horio M, Tohyama M, Shimada S, Imai E, Hori M

Kidney Int　Vol. 53　No. 1　p. 146-153　1998/01　Research paper (scientific journal)

Selective expression of mercurial-insensitive water channel (AQP-4) gene in Hensen and Claudius cells in the rat cochlea

Yuki Minami, Shoichi Shimada, Hiroshi Miyahara, Takashi Matsunaga, Masaya Tohyama

Acta Oto-Laryngologica, Supplement　No. 533　p. 19-21　1998　Research paper (scientific journal)

Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells.

Okada T, Shimada S, Sato K, Kotake Y, Kawai H, Ohta S, Tohyama M, Nishimura T

Neurosci Res　Vol. 30　No. 1　p. 87-90　1998/01　Research paper (scientific journal)

Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines.

Okada T, Fujita M, Shimada S, Sato K, Schloss P, Watanabe Y, Itoh Y, Tohyama M, Nishimura T

Nucl Med Biol　Vol. 25　No. 1　p. 53-58　1998/01　Research paper (scientific journal)

Developmental regulation of Na+/myo-inositol cotransporter gene expression

W Guo, S Shimada, H Tajiri, A Yamauchi, T Yamashita, S Okada, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 51　No. 1-2　p. 91-96　1997/11　Research paper (scientific journal)

Characterization of glycine release mediated by glycine transporter 1 stably expressed in HEK-293 cells

K Sakata, K Sato, P Schloss, H Betz, S Shimada, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 49　No. 1-2　p. 89-94　1997/10　Research paper (scientific journal)

Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin

Y Saishin, S Shimada, H Morimura, K Sato, Ishimoto, I, Y Tano, M Tohyama

FEBS LETTERS　Vol. 414　No. 2　p. 381-386　1997/09　Research paper (scientific journal)

Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells

K Kashiwada, W Nishida, K Hayashi, K Ozawa, Y Yamanaka, H Saga, T Yamashita, M Tohyama, S Shimada, K Sato, K Sobue

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 24　p. 15396-15404　1997/06　Research paper (scientific journal)

Effects of partial nephrectomy on the expression of osmolyte transporters

A Yamauchi, T Sugiura, H Kitamura, A Akagi, M Horio, M Tohyama, S Shimada, E Imai

KIDNEY INTERNATIONAL　Vol. 51　No. 6　p. 1847-1854　1997/06　Research paper (scientific journal)

Induction of Na+/myo-inositol co-transporter mRNA after rat cryogenic injury

T Yamashita, S Shimada, A Yamauchi, W Guo, E Kohmura, T Hayakawa, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 46　No. 1-2　p. 236-242　1997/06　Research paper (scientific journal)

Differential expression patterns of GABA transporters (GAT1-3) in the rat olfactory bulb

M Nishimura, K Sato, M Mizuno, Yoshiya, I, S Shimada, N Saito, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 45　No. 2　p. 268-274　1997/05　Research paper (scientific journal)

Cloning and functional expression of a brain peptide/histidine transporter

T Yamashita, S Shimada, W Guo, K Sato, E Kohmura, T Hayakawa, T Takagi, M Tohyama

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 15　p. 10205-10211　1997/04　Research paper (scientific journal)

Distribution of mRNAs for pituitary adenylate cyclase-activating polypeptide (PACAP), PACAP receptor, vasoactive intestinal polypeptide (VIP), and VIP receptors in the rat superior cervical ganglion

Nogi, H., Hashimoto, H., Hagihara, N., Shimada, S., Yamamoto, K., Matsuda, T., Tohyama, M., Baba, A.

Neuroscience Letters　Vol. 227　No. 1　1997/03　Research paper (scientific journal)

The differential osmoregulation and localization of taurine transporter mRNA and Na+/myo-inositol cotransporter mRNA in rat eyes

H Morimura, S Shimada, Y Otori, Y Saishin, A Yamauchi, Y Minami, K Inoue, Ishimoto, I, Y Tano, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 44　No. 2　p. 245-252　1997/03　Research paper (scientific journal)

Regional distribution of GABA transporter 1 (GAT1) mRNA in the rat brain: Comparison with glutamic acid decarboxylase(67) (GAD(67)) mRNA localization

M Yasumi, K Sato, S Shimada, M Nishimura, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 44　No. 2　p. 205-218　1997/03　Research paper (scientific journal)

Expression of c-fos and c-jun mRNA following transient retinal ischemia: an approach using ligation of the retinal central artery in the rat.

Otori, Y., Shimada, S., Morimura, H., Ishimoto, I., Tohyama, M., Tano, Y.

Survey of ophthalmology　Vol. 42 Suppl 1　1997　Research paper (scientific journal)

Aminetransporters

Shimada, S.

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 42　No. 3 Suppl　1997　Research paper (scientific journal)

GLAST mRNA expression in the periventricular area of experimental hydrocephalus

A Masago, S Shimada, Y Minami, K Inoue, H Morimura, Y Otori, A Miyai, M Tohyama, K Yamada

NEUROREPORT　Vol. 7　No. 15-17　p. 2565-2570　1996/11　Research paper (scientific journal)

Induction of Na+/myo-inositol cotransporter mRNA after focal cerebral ischemia: Evidence for extensive osmotic stress in remote areas

T Yamashita, E Kohmura, A Yamauchi, S Shimada, T Yuguchi, T Sakaki, A Miyai, M Tohyama, T Hayakawa

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 16　No. 6　p. 1203-1210　1996/11　Research paper (scientific journal)

Expression of betaine transporter mRNA: Its unique localization and rapid regulation in rat kidney

A Miyai, A Yamauchi, T Moriyama, T Kaneko, M Takenaka, T Sugiura, H Kitamura, A Ando, M Tohyama, S Shimada, E Imai, T Kamada

KIDNEY INTERNATIONAL　Vol. 50　No. 3　p. 819-827　1996/09　Research paper (scientific journal)

Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats

Y Minami, K Inoue, S Shimada, H Morimura, A Miyai, A Yamauchi, T Matsunaga, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 40　No. 1　p. 64-70　1996/08　Research paper (scientific journal)

Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress

M Asahara, S Mushiake, S Shimada, H Fukui, YA Kinoshita, C Kawanami, T Watanabe, S Tanaka, A Ichikawa, Y Uchiyama, Y Narushima, S Takasawa, H Okamoto, M Tohyama, T Chiba

GASTROENTEROLOGY　Vol. 111　No. 1　p. 45-55　1996/07　Research paper (scientific journal)

Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned rat

M Fujita, H Nishino, M Kumazaki, S Shimada, M Tohyama, T Nishimura

MOLECULAR BRAIN RESEARCH　Vol. 39　No. 1-2　p. 127-136　1996/07　Research paper (scientific journal)

Visualization of ischemic insult in caudate putamen with beta-CIT

M Fujita, S Shimada, M Tohyama, T Nishimura

JOURNAL OF NUCLEAR MEDICINE　Vol. 37　No. 7　p. 1214-1218　1996/07　Research paper (scientific journal)

Changes in glutamate/aspartate transporter (GLAST/GluT-1) mRNA expression following facial nerve transection

T Yamashita, E Kohmura, T Yuguchi, S Shimada, K Tanaka, T Hayakawa, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 38　No. 2　p. 294-299　1996/06　Research paper (scientific journal)

Cellular localization of Na+/MYO-inositol cotransporter mRNA in the rat brain

K Inoue, S Shimada, Y Minami, H Morimura, A Miyai, A Yamauchi, M Tohyama

NEUROREPORT　Vol. 7　No. 6　p. 1195-1198　1996/04　Research paper (scientific journal)

Widespread brain distribution of mRNA encoding the orphan neurotransmitter transporter v7-3

K Inoue, K Sato, M Tohyama, S Shimada, GR Uhl

MOLECULAR BRAIN RESEARCH　Vol. 37　No. 1-2　p. 217-223　1996/04　Research paper (scientific journal)

Cloning of a novel member of fascin/singed gene family from bovine retina

Y. Saishin, S. Shimada, H. Morimura, Y. Otori, I. Ishimoto, M. Tohyama, Y. Tano

Investigative Ophthalmology and Visual Science　Vol. 37　No. 3　1996/02/15　Research paper (scientific journal)

Induction of heat shock protein 70 mRNA in the rat retina under the hypertonic stress

Y. Ikuno, H. Morimura, S. Shimada, Y. Otori, Y. Saishin, I. Ishimoto, M. Tohyama, Y. Tano

Investigative Ophthalmology and Visual Science　Vol. 37　No. 3　1996/02/15　Research paper (scientific journal)

Expression of Na+/myo-inositol cotransporter mRNA in normal and hypertonic stress rat eyes

H Morimura, S Shimada, Y Otori, A Yamauchi, Y Minami, K Inoue, A Miyai, Ishimoto, I, Y Tano, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 35　No. 1-2　p. 333-338　1996/01　Research paper (scientific journal)

Expression of Na+/myo-inositol cotransporter mRNA in the inner ear of the rat

Y Minami, S Shimada, K Inoue, H Morimura, A Miyai, A Yamauchi, T Matsunaga, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 35　No. 1-2　p. 319-324　1996/01　Research paper (scientific journal)

LOCALIZATION AND RAPID REGULATION OF NA+/MYO-INOSITOL COTRANSPORTER IN RAT-KIDNEY

A YAMAUCHI, A MIYAI, S SHIMADA, Y MINAMI, M TOHYAMA, E IMAI, T KAMADA, N UEDA

JOURNAL OF CLINICAL INVESTIGATION　Vol. 96　No. 3　p. 1195-1201　1995/09　Research paper (scientific journal)

THE RAT INTRINSIC-FACTOR GENE - ITS 5'-UPSTREAM REGION AND CHIEF CELL-SPECIFIC TRANSCRIPTION

M MAEDA, S ASAHARA, T NISHI, S MUSHIAKE, T OKA, S SHIMADA, T CHIBA, M TOHYAMA, M FUTAI

JOURNAL OF BIOCHEMISTRY　Vol. 117　No. 6　p. 1305-1311　1995/06　Research paper (scientific journal)

GENE STRUCTURE AND GLIAL EXPRESSION OF THE GLYCINE TRANSPORTER GLYT1 IN EMBRYONIC AND ADULT RODENTS

RH ADAMS, K SATO, S SHIMADA, M TOHYAMA, AW PUSCHEL, H BETZ

JOURNAL OF NEUROSCIENCE　Vol. 15　No. 3　p. 2524-2532　1995/03　Research paper (scientific journal)

CLONING AND EXPRESSION OF A BOVINE GLUTAMATE TRANSPORTER

K INOUE, M SAKAITANI, S SHIMADA, M TOHYAMA

MOLECULAR BRAIN RESEARCH　Vol. 28　No. 2　p. 343-348　1995/02　Research paper (scientific journal)

MARKED INCREASE IN GLUTAMATE-ASPARTATE TRANSPORTER (GLAST/GLUT-1) MESSENGER-RNA FOLLOWING TRANSIENT RETINAL ISCHEMIA

Y OTORI, S SHIMADA, K TANAKA, ISHIMOTO, I, Y TANO, M TOHYAMA

MOLECULAR BRAIN RESEARCH　Vol. 27　No. 2　p. 310-314　1994/12　Research paper (scientific journal)

DISTRIBUTION OF COCAINE RECOGNITION SITES IN RAT-BRAIN - IN-VITRO AND EX-VIVO AUTORADIOGRAPHY WITH [I-125] RTI-55

M FUJITA, S SHIMADA, K FUKUCHI, M TOHYAMA, T NISHIMURA

JOURNAL OF CHEMICAL NEUROANATOMY　Vol. 7　No. 1-2　p. 13-23　1994/07　Research paper (scientific journal)

GENES FOR MEMBERS OF THE GATA-BINDING PROTEIN FAMILY (GATA-GT1 AND GATA-GT2) TOGETHER WITH H+K+-ATPASE ARE SPECIFICALLY TRANSCRIBED IN GASTRIC PARIETAL-CELLS

S MUSHIAKE, Y ETANI, S SHIMADA, M TOHYAMA, M HASEBE, M FUTAI, M MAEDA

FEBS LETTERS　Vol. 340　No. 1-2　p. 117-120　1994/02　Research paper (scientific journal)

CELLULAR-LOCALIZATION OF SEROTONIN TRANSPORTER MESSENGER-RNA IN THE RAT-BRAIN

M FUJITA, S SHIMADA, H MAENO, T NISHIMURA, M TOHYAMA

NEUROSCIENCE LETTERS　Vol. 162　No. 1-2　p. 59-62　1993/11　Research paper (scientific journal)

ONTOGENY OF DOPAMINE TRANSPORTER MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN

M FUJITA, S SHIMADA, T NISHIMURA, GR UHL, M TOHYAMA

MOLECULAR BRAIN RESEARCH　Vol. 19　No. 3　p. 222-226　1993/08　Research paper (scientific journal)

GENE-EXPRESSION OF KA TYPE AND NMDA RECEPTORS AND OF A GLYCINE TRANSPORTER IN THE RAT PINEAL-GLAND

K SATO, H KIYAMA, S SHIMADA, M TOHYAMA

NEUROENDOCRINOLOGY　Vol. 58　No. 1　p. 77-79　1993/07　Research paper (scientific journal)

MURINE SEROTONIN TRANSPORTER - SEQUENCE AND LOCALIZATION TO CHROMOSOME-11

P GREGOR, A PATEL, S SHIMADA, CL LIN, JM ROCHELLE, S KITAYAMA, MF SELDIN, GR UHL

MAMMALIAN GENOME　Vol. 4　No. 5　p. 283-284　1993/05　Research paper (scientific journal)

NEUROTRANSMITTER TRANSPORTER FAMILY CDNAS IN A RAT MIDBRAIN LIBRARY - ORPHAN TRANSPORTERS SUGGEST SIZABLE STRUCTURAL VARIATIONS

GR UHL, S KITAYAMA, P GREGOR, E NANTHAKUMAR, A PERSICO, S SHIMADA

MOLECULAR BRAIN RESEARCH　Vol. 16　No. 3-4　p. 353-359　1992/12　Research paper (scientific journal)

DOPAMINE TRANSPORTER SITE-DIRECTED MUTATIONS DIFFERENTIALLY ALTER SUBSTRATE TRANSPORT AND COCAINE BINDING

S KITAYAMA, S SHIMADA, HX XU, L MARKHAM, DM DONOVAN, GR UHL

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 89　No. 16　p. 7782-7785　1992/08　Research paper (scientific journal)

PARKINSONISM-INDUCING NEUROTOXIN MPP+ - UPTAKE AND TOXICITY IN NONNEURONAL COS CELLS EXPRESSING DOPAMINE TRANSPORTER CDNA

S KITAYAMA, S SHIMADA, GR UHL

ANNALS OF NEUROLOGY　Vol. 32　No. 1　p. 109-111　1992/07　Research paper (scientific journal)

DOPAMINE TRANSPORTER MESSENGER-RNA - DENSE EXPRESSION IN VENTRAL MIDBRAIN NEURONS

S SHIMADA, S KITAYAMA, D WALTHER, G UHL

MOLECULAR BRAIN RESEARCH　Vol. 13　No. 4　p. 359-362　1992/05　Research paper (scientific journal)

GAMMA-AMINOBUTYRIC-ACID A-RECEPTOR OR C-RECEPTOR - GAMMA-AMINOBUTYRIC-ACID RHO-1 RECEPTOR RNA INDUCES BICUCULLINE-INSENSITIVE, BARBITURATE-INSENSITIVE, AND BENZODIAZEPINE-INSENSITIVE GAMMA-AMINOBUTYRIC-ACID RESPONSES IN XENOPUS OOCYTES

S SHIMADA, G CUTTING, GR UHL

MOLECULAR PHARMACOLOGY　Vol. 41　No. 4　p. 683-687　1992/04　Research paper (scientific journal)

SYNAPTIC CONTACTS BETWEEN CGRP-IMMUNOREACTIVE TERMINALS AND ENKEPHALIN-IMMUNOREACTIVE NEURONS IN THE CENTRAL AMYGDALOID NUCLEUS OF THE RAT

S SHIMADA, S INAGAKI, N NARITA, H TAKAGI

NEUROSCIENCE LETTERS　Vol. 134　No. 2　p. 243-246　1992/01　Research paper (scientific journal)

Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA

S Shimada, S Kitayama, C. Lin, A Patel, E Nanthakumar, P Gregor, M Kuhar, G Uhl

Science　Vol. 254　No. 5031　p. 576-578　1991/10/25　Research paper (scientific journal)

CLONING OF THE GAMMA-AMINOBUTYRIC-ACID (GABA) RHO-1 CDNA - A GABA RECEPTOR SUBUNIT HIGHLY EXPRESSED IN THE RETINA

GR CUTTING, L LU, BF OHARA, LM KASCH, C MONTROSERAFIZADEH, DM DONOVAN, S SHIMADA, SE ANTONARAKIS, WB GUGGINO, GR UHL, HH KAZAZIAN

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 88　No. 7　p. 2673-2677　1991/04　Research paper (scientific journal)

STRIATAL CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVE AFFERENTS FROM THE REGIONS VENTRAL AND MEDIAL TO THE MEDIAL GENICULATE-NUCLEUS OF RATS

Y KUBOTA, S INAGAKI, S SHIMADA, K TAKATSUJI, M TOHYAMA, H TAKAGI

NEUROSCIENCE　Vol. 40　No. 2　p. 423-428　1991/02　Research paper (scientific journal)

DOPAMINE TRANSPORTER - EXPRESSION IN XENOPUS OOCYTES

GR UHL, B OHARA, S SHIMADA, R ZACZEK, J DIGIORGIANNI, T NISHIMORI

MOLECULAR BRAIN RESEARCH　Vol. 9　No. 1-2　p. 23-29　1991/01　Research paper (scientific journal)

ENDOTHELIN RECEPTOR - A PROFOUNDLY DESENSITIZING RECEPTOR EXPRESSED IN XENOPUS OOCYTES

S SHIMADA, C SPIVAK, G UHL

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 193　No. 1　p. 123-125　1991/01　Research paper (scientific journal)

SPINY AND ASPINY TYPES OF NEUROPEPTIDE-Y IMMUNOREACTIVE NEURONS IN THE MONKEY NEOSTRIATUM

Y KUBOTA, S INAGAKI, S SHIMADA, H TAKAGI

NEUROSCIENCE LETTERS　Vol. 122　No. 1　p. 109-112　1991/01　Research paper (scientific journal)

INSITU HYBRIDIZATION ANALYSIS OF THE SOMATOSTATIN-CONTAINING NEURON SYSTEM IN DEVELOPING CEREBELLUM OF RATS

S INAGAKI, S SHIOSAKA, M SEKITANI, K NOGUCHI, S SHIMADA, H TAKAGI

MOLECULAR BRAIN RESEARCH　Vol. 6　No. 4　p. 289-295　1989/12　Research paper (scientific journal)

THE COLOCALIZATION OF SUBSTANCE-P-LIKE AND SOMATOSTATIN-LIKE PEPTIDES IN NEURONS OF THE ENTOPEDUNCULAR NUCLEUS OF RATS

S MURAKAMI, S INAGAKI, S SHIMADA, Y KUBOTA, S KITO, N OGAWA, H TAKAGI

PEPTIDES　Vol. 10　No. 5　p. 973-977　1989/09　Research paper (scientific journal)

LIGHT AND ELECTRON-MICROSCOPIC STUDIES OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVE TERMINALS IN THE CENTRAL NUCLEUS OF THE AMYGDALA AND THE BED NUCLEUS OF THE STRIA TERMINALIS OF THE RAT

S SHIMADA, S INAGAKI, Y KUBOTA, S KITO, H FUNAKI, H TAKAGI

EXPERIMENTAL BRAIN RESEARCH　Vol. 77　No. 1　p. 217-220　1989/08　Research paper (scientific journal)

COEXISTENCE OF PEPTIDES (CORTICOTROPIN RELEASING-FACTOR NEUROTENSIN AND SUBSTANCE-P SOMATOSTATIN) IN THE BED NUCLEUS OF THE STRIA TERMINALIS AND CENTRAL AMYGDALOID NUCLEUS OF THE RAT

S SHIMADA, S INAGAKI, Y KUBOTA, N OGAWA, T SHIBASAKI, H TAKAGI

NEUROSCIENCE　Vol. 30　No. 2　p. 377-383　1989/07　Research paper (scientific journal)

A LIGHT AND ELECTRON-MICROSCOPIC STUDY OF CALCITONIN GENE-RELATED PEPTIDE IN THE RAT CAUDATE PUTAMEN

T OKAYAMA, Y KUBOTA, S KITO, H FUNAKI, S SHIMADA, H TAKAGI, S INAGAKI

BRAIN RESEARCH BULLETIN　Vol. 22　No. 4　p. 657-663　1989/04　Research paper (scientific journal)

THE COEXISTENCE OF SUBSTANCE-P-LIKE AND GLUTAMIC-ACID DECARBOXYLASE-LIKE IMMUNOREACTIVITY IN ENTOPEDUNCULAR NEURONS OF THE RAT

S MURAKAMI, Y KUBOTA, S KITO, S SHIMADA, H TAKAGI, JY WU, S INAGAKI

BRAIN RESEARCH　Vol. 485　No. 2　p. 403-406　1989/04　Research paper (scientific journal)

ONTOGENY OF CALCITONIN GENE-RELATED PEPTIDE-IMMUNOREACTIVE STRUCTURES IN THE RAT FOREBRAIN AND DIENCEPHALON

S INAGAKI, Y KUBOTA, S SHIMADA, M TOHYAMA, S KITO, MACINTYRE, I, H TAKAGI

DEVELOPMENTAL BRAIN RESEARCH　Vol. 43　No. 2　p. 235-248　1988/10　Research paper (scientific journal)

ONTOGENY OF THE CALCITONIN GENE-RELATED PEPTIDE IN THE NERVOUS-SYSTEM OF RAT-BRAIN STEM - AN IMMUNOHISTOCHEMICAL ANALYSIS

Y KUBOTA, S INAGAKI, S SHIMADA, S GIRGIS, M ZADI, MACINTYRE, I, M TOHYAMA, S KITO

NEUROSCIENCE　Vol. 26　No. 3　p. 905-926　1988/09　Research paper (scientific journal)

NEUROPEPTIDE Y-IMMUNOREACTIVE NEURONS RECEIVE SYNAPTIC INPUTS FROM DOPAMINERGIC AXON TERMINALS IN THE RAT NEOSTRIATUM

Y KUBOTA, S INAGAKI, S KITO, S SHIMADA, T OKAYAMA, H HATANAKA, G PELLETIER, H TAKAGI, M TOHYAMA

BRAIN RESEARCH　Vol. 458　No. 2　p. 389-393　1988/08　Research paper (scientific journal)

COEXISTENCE OF SUBSTANCE-P AND NEUROTENSIN-LIKE PEPTIDES IN SINGLE NEURONS OF THE RAT HYPOTHALAMUS

S SHIMADA, S INAGAKI, Y KUBOTA, S KITO, Y SHIOTANI, M TOHYAMA

PEPTIDES　Vol. 9　No. 1　p. 71-76　1988/01　Research paper (scientific journal)

COEXISTENCE OF SUBSTANCE-P-LIKE AND ENKEPHALIN-LIKE PEPTIDES IN SINGLE NEURONS OF THE RAT HYPOTHALAMUS

S SHIMADA, S INAGAKI, Y KUBOTA, S KITO, Y SHIOTANI, M TOHYAMA

BRAIN RESEARCH　Vol. 425　No. 2　p. 256-262　1987/11　Research paper (scientific journal)

NEOSTRIATAL CHOLINERGIC NEURONS RECEIVE DIRECT SYNAPTIC INPUTS FROM DOPAMINERGIC AXONS

Y KUBOTA, S INAGAKI, S SHIMADA, S KITO, F ECKENSTEIN, M TOHYAMA

BRAIN RESEARCH　Vol. 413　No. 1　p. 179-184　1987/06　Research paper (scientific journal)

Transient appearance of calcitonin gene-related peptide-like immunoreactive fibers in the developing cerebellum of the rat

Kubota, Y., Inagaki, S., Shimada, S., Kito, S., Zaidi, M., Girgis, S.I., MacIntyre, I., Tohyama, M.

Brain Research　Vol. 415　No. 2　1987/06　Research paper (scientific journal)

GLUTAMATE DECARBOXYLASE-LIKE IMMUNOREACTIVE NEURONS IN THE RAT CAUDATE PUTAMEN

Y KUBOTA, S INAGAKI, S SHIMADA, S KITO, JY WU

BRAIN RESEARCH BULLETIN　Vol. 18　No. 6　p. 687-697　1987/06　Research paper (scientific journal)

SENSITIVE DOUBLE-LABELING TECHNIQUE OF RETROGRADE BIOTINIZED TRACER (BIOTIN-WGA) AND IMMUNOCYTOCHEMISTRY - LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS

S SHIOSAKA, S SHIMADA, M TOHYAMA

JOURNAL OF NEUROSCIENCE METHODS　Vol. 16　No. 1　p. 9-18　1986/03　Research paper (scientific journal)

CALCITONIN GENE-RELATED PEPTIDERGIC PROJECTION FROM THE PARABRACHIAL AREA TO THE FOREBRAIN AND DIENCEPHALON IN THE RAT - AN IMMUNOHISTOCHEMICAL ANALYSIS

S SHIMADA, S SHIOSAKA, PC EMSON, CJ HILLYARD, S GIRGIS, MACINTYRE, I, M TOHYAMA

NEUROSCIENCE　Vol. 16　No. 3　p. 607-616　1985/11　Research paper (scientific journal)

CALCITONIN GENE-RELATED PEPTIDE PROJECTION FROM THE VENTROMEDIAL THALAMIC NUCLEUS TO THE INSULAR CORTEX - A COMBINED RETROGRADE TRANSPORT AND IMMUNOCYTOCHEMICAL STUDY

S SHIMADA, S SHIOSAKA, CJ HILLYARD, SI GIRGIS, MACINTYRE, I, PC EMSON, M TOHYAMA

BRAIN RESEARCH　Vol. 344　No. 1　p. 200-203　1985/09　Research paper (scientific journal)

Somatostatinergic neurons in the insular cortex project to the spinal cord: combined retrograde axonal transport and immunohistochemical study

Shoichi Shimada, Sadao Shiosaka, Kenji Takami, Mariko Yamano, Masaya Tohyama

Brain Research　Vol. 326　No. 1　p. 197-200　1985/02　Research paper (scientific journal)

SOMATOSTATINERGIC NEURONS IN THE INSULAR CORTEX PROJECT TO THE SPINAL-CORD - COMBINED RETROGRADE AXONAL-TRANSPORT AND IMMUNOHISTOCHEMICAL STUDY

S SHIMADA, S SHIOSAKA, K TAKAMI, M YAMANO, M TOHYAMA

ACTA HISTOCHEMICA ET CYTOCHEMICA　Vol. 17　No. 6　p. 701-701　1984　Research paper (scientific journal)