Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon.

Mugen Taniguchi, Ryu Okumura, Takahisa Matsuzaki, Ayaka Nakatani, Kei Sakaki, Shota Okamoto, Airi Ishibashi, Haruka Tani, Momoka Horikiri, Naritaka Kobayashi, Hiroshi Y Yoshikawa, Daisuke Motooka, Daisuke Okuzaki, Shota Nakamura, Toshiyuki Kida, Akihiko Kameyama, Kiyoshi Takeda

Mucosal immunology　Vol. 16　No. 5　p. 624-641　2023/07/13　Research paper (scientific journal)

TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses.

Thanyakorn Chalalai, Naganori Kamiyama, Benjawan Saechue, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Astri Dewayani, Yasuhiro Soga, Yomei Kagoshima, Supanuch Ekronarongchai, Ryu Okumura, Hisako Kayama, Kiyoshi Takeda, Takashi Kobayashi

Biochemical and biophysical research communications　Vol. 669　p. 103-112　2023/05/27　Research paper (scientific journal)

Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of patients with rheumatoid arthritis.

Takuro Nii, Yuichi Maeda, Daisuke Motooka, Mariko Naito, Yuki Matsumoto, Takao Ogawa, Eri Oguro-Igashira, Toshihiro Kishikawa, Makoto Yamashita, Satoshi Koizumi, Takashi Kurakawa, Ryu Okumura, Hisako Kayama, Mari Murakami, Taiki Sakaguchi, Bhabatosh Das, Shota Nakamura, Yukinori Okada, Atsushi Kumanogoh, Kiyoshi Takeda

Annals of the rheumatic diseases　Vol. 82　No. 5　p. 621-629　2023/01/10　Research paper (scientific journal)

Low Surface Potential with Glycoconjugates Determines Insect Cell Adhesion at Room Temperature

Takahisa Matsuzaki, Daigo Terutsuki, Shoma Sato, Kohei Ikarashi, Kohei Sato, Hidefumi Mitsuno, Ryu Okumura, Yudai Yoshimura, Shigeyoshi Usami, Yusuke Mori, Mai Fujii, Shota Takemi, Seiichiro Nakabayashi, Hiroshi Y. Yoshikawa, Ryohei Kanzaki

The Journal of Physical Chemistry Letters　p. 9494-9500　2022/10/06　Research paper (scientific journal)

An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia.

Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Kiyoshi Takeda, Akihiro Tsuboi, Keiichi Ozono

Cancer immunology, immunotherapy : CII　2022/06/14　Research paper (scientific journal)

Pyruvate enhances oral tolerance via GPR31

Qizhi Liu, Eiji Umemoto, Naoki Morita, Hisako Kayama, Yoshihiro Baba, Tomohiro Kurosaki, Ryu Okumura, Kiyoshi Takeda

International Immunology　2022/03/18　Research paper (scientific journal)

Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.

Siddhika Pareek, Xenia Sanchenkova, Taiki Sakaguchi, Mari Murakami, Ryu Okumura, Hisako Kayama, Saya Kawauchi, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Tadamitsu Kishimoto, Kiyoshi Takeda

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 27　No. 4　p. 243-253　2022/01/25　Research paper (scientific journal)

The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.

Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, Takayuki Ogino, Shih-Han Tsai, Yoki Furuta, Masato Muneta, Shota Nakamura, Eiichiro Fukusaki, Kimiko Yamamoto, Hideo Yagita, Hisako Kayama, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 39　2021/09/28　Research paper (scientific journal)

Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier

Sotaro Ozaka, Akira Sonoda, Shimpei Ariki, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Kanako Ito, Yoko Kudo, Mizuki Minata, Benjawan Saechue, Astri Dewayani, Thanyakorn Chalalai, Yasuhiro Soga, Yuya Takahashi, Chiaki Fukuda, Kazuhiro Mizukami, Ryu Okumura, Hisako Kayama, Kazunari Murakami, Kiyoshi Takeda, Takashi Kobayashi

Genes to Cells　2021/08/17　Research paper (scientific journal)

Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn's Disease.

Yoshifumi Watanabe, Tsunekazu Mizushima, Ryu Okumura, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Kiyoshi Takeda, Yuichiro Doki, Hidetoshi Eguchi

Digestive diseases and sciences　Vol. 67　No. 6　p. 2143-2157　2021/05/26　Research paper (scientific journal)

Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel diseases (IBD).

Chiao-Ching Hsu, Ryu Okumura, Daisuke Motooka, Reo Sasaki, Shota Nakamura, Tetsuya Iida, Kiyoshi Takeda

International immunology　2021/04/05　Research paper (scientific journal)

Oral intake of silica nanoparticles exacerbates intestinal inflammation.

Takao Ogawa, Ryu Okumura, Kazuya Nagano, Tomomi Minemura, Masahiro Izumi, Daisuke Motooka, Shota Nakamura, Tetsuya Iida, Yuichi Maeda, Atsushi Kumanogoh, Yasuo Tsutsumi, Kiyoshi Takeda

Biochemical and biophysical research communications　Vol. 534　p. 540-546　2021/01/01　Research paper (scientific journal)

Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8.

Takahide Ara, Daigo Hashimoto, Eiko Hayase, Clara Noizat, Ryo Kikuchi, Yuta Hasegawa, Kana Matsuda, Shoko Ono, Yoshihiro Matsuno, Ko Ebata, Reiki Ogasawara, Shuichiro Takahashi, Hiroyuki Ohigashi, Emi Yokoyama, Keitaro Matsuo, Junichi Sugita, Masahiro Onozawa, Ryu Okumura, Kiyoshi Takeda, Takanori Teshima

Science translational medicine　Vol. 12　No. 550　2020/07/01　Research paper (scientific journal)

TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

Taiki Sakaguchi, Ryu Okumura, Chisato Ono, Daisuke Okuzaki, Takafumi Kawai, Yoshifumi Okochi, Natsuko Tanimura, Mari Murakami, Hisako Kayama, Eiji Umemoto, Hidetaka Kioka, Tomohito Ohtani, Yasushi Sakata, Kensuke Miyake, Yasushi Okamura, Yoshihiro Baba, Kiyoshi Takeda

Cell reports　Vol. 31　No. 10　p. 107755-107755　2020/06/09　Research paper (scientific journal)

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.

Hisako Kayama, Ryu Okumura, Kiyoshi Takeda

Annual review of immunology　Vol. 38　p. 23-48　2020/04/26　Research paper (scientific journal)

Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia.

Ryu Okumura, Toshio Kodama, Chiao-Ching Hsu, Benjamin Heller Sahlgren, Shota Hamano, Takashi Kurakawa, Tetsuya Iida, Kiyoshi Takeda

Mucosal immunology　Vol. 13　No. 1　p. 75-85　2020/01　Research paper (scientific journal)

Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi.

Siddhika Pareek, Takashi Kurakawa, Bhabatosh Das, Daisuke Motooka, Shuuichi Nakaya, Temsunaro Rongsen-Chandola, Nidhi Goyal, Hisako Kayama, Dylan Dodd, Ryu Okumura, Yuichi Maeda, Kosuke Fujimoto, Takuro Nii, Takao Ogawa, Tetsuya Iida, Nita Bhandari, Toshiyuki Kida, Shota Nakamura, G Balakrish Nair, Kiyoshi Takeda

NPJ biofilms and microbiomes　Vol. 5　p. 37-37　2019/12　Research paper (scientific journal)

BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway.

Kayama H, Tani H, Kitada S, Opasawatchai A, Okumura R, Motooka D, Nakamura S, Takeda K

International immunology　Vol. 31　No. 6　p. 371-383　2019/05　Research paper (scientific journal)

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.

Naoki Morita, Eiji Umemoto, Setsuko Fujita, Akio Hayashi, Junichi Kikuta, Ikuo Kimura, Takeshi Haneda, Toshio Imai, Asuka Inoue, Hitomi Mimuro, Yuichi Maeda, Hisako Kayama, Ryu Okumura, Junken Aoki, Nobuhiko Okada, Toshiyuki Kida, Masaru Ishii, Ryusuke Nabeshima, Kiyoshi Takeda

Nature　Vol. 566　No. 7742　p. 110-114　2019/02　Research paper (scientific journal)

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 33　p. 8418-8423　2018/08/14　Research paper (scientific journal)

Non-ischemic heart failure with reduced ejection fraction is associated with altered intestinal microbiota

Themistoklis Katsimichas, Tomohito Ohtani, Daisuke Motooka, Yasumasa Tsukamoto, Hidetaka Kioka, Kei Nakamoto, Shozo Konishi, Misato Chimura, Kaoruko Sengoku, Hiroshi Miyawaki, Taiki Sakaguchi, Ryu Okumura, Konstantinos Theofilis, Tetsuya Iida, Kiyoshi Takeda, Shota Nakamura, Yasushi Sakata

Circulation Journal　Vol. 82　No. 6　p. 1640-1650　2018　Research paper (scientific journal)

Maintenance of intestinal homeostasis by mucosal barriers.

Okumura R, Takeda K

Inflammation and regeneration　Vol. 38　2018

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

CELL REPORTS　Vol. 21　No. 7　p. 1824-1838　2017/11　Research paper (scientific journal)

Roles of intestinal epithelial cells in the maintenance of gut homeostasis

Ryu Okumura, Kiyoshi Takeda

EXPERIMENTAL AND MOLECULAR MEDICINE　Vol. 49　No. 5　2017/05

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186

Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita, Kiyoshi Takeda

MUCOSAL IMMUNOLOGY　Vol. 10　No. 2　p. 446-459　2017/03　Research paper (scientific journal)

E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine

Yoki Furuta, Shih-Han Tsai, Makoto Kinoshita, Kosuke Fujimoto, Ryu Okumura, Eiji Umemoto, Yosuke Kurashima, Hiroshi Kiyono, Hisako Kayama, Kiyoshi Takeda

PLOS ONE　Vol. 12　No. 2　2017/02　Research paper (scientific journal)

Human LYPD8 protein inhibits motility of flagellated bacteria.

Hsu CC, Okumura R, Takeda K

Inflammation and regeneration　Vol. 37　p. 23-23　2017　Research paper (scientific journal)

Maintenance of gut homeostasis by the mucosal immune system

Ryu Okumura, Kiyoshi Takeda

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES　Vol. 92　No. 9　p. 423-435　2016/11

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano, Kiyoshi Takeda

NATURE　Vol. 532　No. 7597　p. 117-+　2016/04　Research paper (scientific journal)

The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells

Shih Han Tsai, Makoto Kinoshita, Takashi Kusu, Hisako Kayama, Ryu Okumura, Kayo Ikeda, Yosuke Shimada, Akira Takeda, Soichiro Yoshikawa, Kazushige Obata-Ninomiya, Yosuke Kurashima, Shintaro Sato, Eiji Umemoto, Hiroshi Kiyono, Hajime Karasuyama, Kiyoshi Takeda

Immunity　Vol. 42　No. 2　p. 279-293　2015/02/17　Research paper (scientific journal)

Generation of colonic IgA-secreting cells in the caecal patch

Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima, Osamu Yoshie, Masahiro Fukuzawa, Hiroshi Kiyono, Sidonia Fagarasan, Tetsuya Iida, Masaru Ishii, Kiyoshi Takeda

NATURE COMMUNICATIONS　Vol. 5　2014/04　Research paper (scientific journal)

Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda

JOURNAL OF IMMUNOLOGY　Vol. 190　No. 2　p. 774-783　2013/01　Research paper (scientific journal)

Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon

Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda

PLoS Pathogens　Vol. 8　No. 5　2012/05　Research paper (scientific journal)

Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis

Hisako Kayama, Yoshiyasu Ueda, Yukihisa Sawa, Seong Gyu Jeon, Ji Su Ma, Ryu Okumura, Atsuko Kubo, Masaru Ishii, Taku Okazaki, Masaaki Murakami, Masahiro Yamamoto, Hideo Yagita, Kiyoshi Takeda

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 109　No. 13　p. 5010-5015　2012/03　Research paper (scientific journal)