Functional dissection of Rab GTPases involved in primary cilium formation

Shin-ichiro Yoshimura, Johannes Egerer, Evelyn Fuchs, Alexander K. Haas, Francis A. Barr

JOURNAL OF CELL BIOLOGY　Vol. 178　No. 3　p. 363-369　2007/07　Research paper (scientific journal)

Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network.

Shin-Ichiro Yoshimura, Tomoaki Sobajima, Masataka Kunii, Akihiro Harada

Proceedings of the National Academy of Sciences of the United States of America　Vol. 122　No. 22　2025/06/03　Research paper (scientific journal)

Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation.

Yu Zhang, Masataka Kunii, Manabu Taniguchi, Shin-Ichiro Yoshimura, Akihiro Harada

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 44　No. 27　2024/07/03　Research paper (scientific journal)

Dynamic movement of the Golgi unit and its glycosylation enzyme zones

Akihiro Harada, Masataka Kunii, Kazuo Kurokawa, Takuya Sumi, Satoshi Kanda, Yu Zhang, Satomi Nadanaka, Koichiro M. Hirosawa, Kazuaki Tokunaga, Takuro Tojima, Manabu Taniguchi, Kenta Moriwaki, Shin-ichiro Yoshimura, Miki Yamamoto-Hino, Satoshi Goto, Toyomasa Katagiri, Satoshi Kume, Mitsuko Hayashi-Nishino, Miyako Nakano, Eiji Miyoshi, Kenichi G. N. Suzuki, Hiroshi Kitagawa, Akihiko Nakano

Nature Communications　Vol. 15　No. 1　2024/05/27　Research paper (scientific journal)

EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.

Ji Wu, Kenta Moriwaki, Tatsuya Asuka, Ritsuko Nakai, Satoshi Kanda, Manabu Taniguchi, Tatsuki Sugiyama, Shin-Ichiro Yoshimura, Masataka Kunii, Takashi Nagasawa, Naoki Hosen, Eiji Miyoshi, Akihiro Harada

Blood advances　2023/04/12　Research paper (scientific journal)

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.

Kohei Tsujimoto, Tatsunori Jo, Daiki Nagira, Hachiro Konaka, Jeong Hoon Park, Shin-Ichiro Yoshimura, Akinori Ninomiya, Fuminori Sugihara, Takehiro Hirayama, Eri Itotagawa, Yusei Matsuzaki, Yuki Takaichi, Wataru Aoki, Shotaro Saita, Shuhei Nakamura, Andrea Ballabio, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

The EMBO journal　Vol. 42　No. 1　2022/11/29　Research paper (scientific journal)

PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.

Yukako Oe, Keita Kakuda, Shin-Ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura

PLoS genetics　Vol. 18　No. 6　2022/06　Research paper (scientific journal)

SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity.

Masataka Kunii, Yuria Noguchi, Shin-Ichiro Yoshimura, Satoshi Kanda, Tomohiko Iwano, Erda Avriyanti, Nur Atik, Takashi Sato, Ken Sato, Masaharu Ogawa, Akihiro Harada

The Journal of cell biology　Vol. 220　No. 1　2021/01/04　Research paper (scientific journal)

Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.

Ayano Iwaki, Kenta Moriwaki, Tomoaki Sobajima, Manabu Taniguchi, Shin-Ichiro Yoshimura, Masataka Kunii, Satoshi Kanda, Yoshihiro Kamada, Eiji Miyoshi, Akihiro Harada

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 34　No. 7　p. 9450-9465　2020/06/04　Research paper (scientific journal)

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Tomoya Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Genta Ito, Shin-ichiro Yoshimura, Akihiro Harada, Mitsunori Fukuda, Masato Koike, Takeshi Iwatsubo

Proceedings of the National Academy of Sciences　Vol. 115　No. 39　p. E9115-E9124　2018/09/25　Research paper (scientific journal)

BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain

Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shin-ichiro Yoshimura, Kenta Moriwaki, Akihiro Harada

PLOS ONE　Vol. 12　No. 4　2017/04　Research paper (scientific journal)

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

Masataka Kunii, Mica Ohara-Imaizumi, Noriko Takahashi, Masaki Kobayashi, Ryosuke Kawakami, Yasumitsu Kondoh, Takeshi Shimizu, Siro Simizu, Bangzhong Lin, Kazuto Nunomura, Kyota Aoyagi, Mitsuyo Ohno, Masaki Ohmuraya, Takashi Sato, Shin-ichiro Yoshimura, Ken Sato, Reiko Harada, Yoon-Jeong Kim, Hiroyuki Osada, Tomomi Nemoto, Haruo Kasai, Tadahiro Kitamura, Shinya Nagamatsu, Akihiro Harada

JOURNAL OF CELL BIOLOGY　Vol. 215　No. 1　p. 121-138　2016/10　Research paper (scientific journal)

Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity

Erda Avriyanti, Nur Atik, Masataka Kunii, Naomi Furumoto, Tomohiko Iwano, Shin-ichiro Yoshimura, Reiko Harada, Akihiro Harada

NEUROSCIENCE RESEARCH　Vol. 95　p. 12-20　2015/06　Research paper (scientific journal)

Rab11a is required for apical protein localisation in the intestine

Tomoaki Sobajima, Shin-ichiro Yoshimura, Tomohiko Iwano, Masataka Kunii, Masahiko Watanabe, Nur Atik, Sotaro Mushiake, Eiichi Morii, Yoshihisa Koyama, Eiji Miyoshi, Akihiro Harada

BIOLOGY OPEN　Vol. 4　No. 1　p. 86-94　2015/01　Research paper (scientific journal)

Rab18 and a Rab18 GEF complex are required for normal ER structure

Andreas Gerondopoulos, Ricardo Nunes Bastos, Shin-ichiro Yoshimura, Rachel Anderson, Sarah Carpanini, Irene Aligianis, Mark T. Handley, Francis A. Barr

JOURNAL OF CELL BIOLOGY　Vol. 205　No. 5　p. 707-720　2014/06　Research paper (scientific journal)

The Role of PKD in Cell Polarity, Biosynthetic Pathways, and Organelle/F-actin Distribution

Nur Atik, Masataka Kunii, Erda Avriyanti, Naomi Furumoto, Keiko Inami, Shin-ichiro Yoshimura, Reiko Harada, Akihiro Harada

CELL STRUCTURE AND FUNCTION　Vol. 39　No. 1　p. 61-77　2014　Research paper (scientific journal)

Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector

Yukiko Hashimoto, Kazuhiro Muramatsu, Masataka Kunii, Shin-Ichiro Yoshimura, Minami Yamada, Takashi Sato, Yasumasa Ishida, Reiko Harada, Akihiro Harada

FASEB Journal　Vol. 26　No. 11　p. 4662-4674　2012/11　Research paper (scientific journal)

TBC1D14 regulates autophagosome formation via Rab11-and ULK1-positive recycling endosomes

Andrea Longatti, Christopher A. Lamb, Minoo Razi, Shin-ichiro Yoshimura, Francis A. Barr, Sharon A. Tooze

JOURNAL OF CELL BIOLOGY　Vol. 197　No. 5　p. 659-675　2012/05　Research paper (scientific journal)

The Role of VAMP7/TI-VAMP in Cell Polarity and Lysosomal Exocytosis in vivo

Mahito Sato, Shinichiro Yoshimura, Rika Hirai, Ayako Goto, Masataka Kunii, Nur Atik, Takashi Sato, Ken Sato, Reiko Harada, Junko Shimada, Toshimitsu Hatabu, Hiroshi Yorifuji, Akihiro Harada

TRAFFIC　Vol. 12　No. 10　p. 1383-1393　2011/10　Research paper (scientific journal)

Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment

Helen L. Zenner, Shin-ichiro Yoshimura, Francis A. Barr, Colin M. Crump

JOURNAL OF VIROLOGY　Vol. 85　No. 16　p. 8012-8021　2011/08　Research paper (scientific journal)

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

Danai Bem, Shin-Ichiro Yoshimura, Ricardo Nunes-Bastos, Frances F. Bond, Manju A. Kurian, Fatima Rahman, Mark T. W. Handley, Yavor Hadzhiev, Imran Masood, Ania A. Straatman-Iwanowska, Andrew R. Cullinane, Alisdair McNeill, Shanaz S. Pasha, Gail A. Kirby, Katharine Foster, Zubair Ahmed, Jenny E. Morton, Denise Williams, John M. Graham, William B. Dobyns, Lydie Burglen, John R. Ainsworth, Paul Gissen, Ferenc Mueller, Eamonn R. Maher, Francis A. Barr, Irene A. Aligianis

AMERICAN JOURNAL OF HUMAN GENETICS　Vol. 88　No. 4　p. 499-507　2011/04　Research paper (scientific journal)

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C

Chieh Hsu, Yuichi Morohashi, Shin-ichiro Yoshimura, Natalia Manrique-Hoyos, SangYong Jung, Marcel A. Lauterbach, Mostafa Bakhti, Mads Gronborg, Wiebke Moebius, JeongSeop Rhee, Francis A. Barr, Mikael Simons

JOURNAL OF CELL BIOLOGY　Vol. 189　No. 2　p. 223-232　2010/04　Research paper (scientific journal)

YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure

Yumi Yoshida, Kurumi Suzuki, Akitsugu Yamamoto, Noriko Sakai, Misako Bando, Kouji Tanimoto, Youko Yamaguchi, Tomoaki Sakaguchi, Hasina Akhter, Gourou Fujii, Shin-ichiro Yoshimura, Shigenori Ogata, Miwa Sohda, Yoshio Misumi, Nobuhiro Nakamura

EXPERIMENTAL CELL RESEARCH　Vol. 314　No. 19　p. 3427-3443　2008/11　Research paper (scientific journal)

ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65

Blaine Bisel, Yanzhuang Wang, Jen-Hsuan Wei, Yi Xiang, Danming Tang, Miguel Miron-Mendoza, Shin-ichiro Yoshimura, Nobuhiro Nakamura, Joachim Seemann

JOURNAL OF CELL BIOLOGY　Vol. 182　No. 5　p. 837-843　2008/09　Research paper (scientific journal)

Analysis of Rab GTPase and GTPase-activating protein function at primary cilia

Shin-ichiro Yoshimura, Alexander K. Haas, Francis A. Barr

SMALL GTPASES IN DISEASE, PT B　Vol. 439　p. 353-364　2008　Part of collection (book)

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Alexander K. Haas, Shin-ichiro Yoshimura, David J. Stephens, Christian Preisinger, Evelyn Fuchs, Francis A. Barr

JOURNAL OF CELL SCIENCE　Vol. 120　No. 17　p. 2997-3010　2007/09　Research paper (scientific journal)

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Evelyn Fuchs, Alexander K. Haas, Robert A. Spooner, Shin-Ichiro Yoshimura, J. Michael Lord, Francis A. Barr

JOURNAL OF CELL BIOLOGY　Vol. 177　No. 6　p. 1133-1143　2007/06　Research paper (scientific journal)

The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity

Miwa Sohda, Yoshio Misumi, Shin-ichiro Yoshimura, Nobuhiro Nakamura, Takami Fusano, Shigenori Ogata, Shotaro Sakisaka, Yukio Ikehara

TRAFFIC　Vol. 8　No. 3　p. 270-284　2007/03　Research paper (scientific journal)

Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport

M Sohda, Y Misumi, S Yoshimura, N Nakamura, T Fusano, S Sakisaka, S Ogata, J Fujimoto, N Kiyokawa, Y Ikehara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 338　No. 2　p. 1268-1274　2005/12　Research paper (scientific journal)

Convergence of cell cycle regulation and growth factor signals on GRASP65

S Yoshimura, K Yoshioka, FA Barr, M Lowe, K Nakayama, S Ohkuma, N Nakamura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 24　p. 23048-23056　2005/06　Research paper (scientific journal)

Dynamics of golgi matrix proteins after the blockage of ER to golgi transport

S Yoshimura, A Yamamoto, Y Misumi, M Sohda, FA Barr, G Fujii, A Shakoori, H Ohno, K Mihara, N Nakamura

JOURNAL OF BIOCHEMISTRY　Vol. 135　No. 2　p. 201-216　2004/02　Research paper (scientific journal)

Seeds of the Golgi apparatus

Nakamura, N., Yoshimura, S.

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 49　No. 7 Suppl　2004　Research paper (scientific journal)

Identification of a five-pass transmembrane protein family localizing in the Golgi apparatus and the ER

A Shakoori, G Fujii, S Yoshimura, M Kitamura, K Nakayama, T Ito, H Ohno, N Nakamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 312　No. 3　p. 850-857　2003/12　Research paper (scientific journal)

Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus

S Yoshimura, N Nakamura, FA Barr, Y Misumi, Y Ikehara, H Ohno, M Sakaguchi, K Mihara

JOURNAL OF CELL SCIENCE　Vol. 114　No. 22　p. 4105-4115　2001/11　Research paper (scientific journal)

Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome critical region gene 5)

DK Choi, Y Suzuki, S Yoshimura, T Togashi, M Hida, TD Taylor, YP Wang, S Sugano, M Hattori, Y Sakaki

MAMMALIAN GENOME　Vol. 12　No. 5　p. 347-351　2001/05　Research paper (scientific journal)