Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range

Saki Yoshioka, Yuya Arakawa, Mika Hasegawa, Shiho Kato, Hinako Hashimoto, Saho Mori, Hiromichi Ueda, Osaka Twin Research Group, Mikio Watanabe

Epigenomics　Vol. 16　No. 3　p. 147-158　2024/01/24　Research paper (scientific journal)

Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins

Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Hiroshi Sawabe, Hiroyasu Inui, Ayami Saga, Takeshi Okada, Tomoaki Higo, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Mikio Watanabe, Osaka Twin Research Group

Journal of Atherosclerosis and Thrombosis　2024　Research paper (scientific journal)

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

Endocrine Journal　Vol. 70　No. 12　p. 1169-1174　2023/12　Research paper (scientific journal)

Rigorous evaluation of genetic and epigenetic effects on clinical laboratory measurements using Japanese monozygotic twins

Jumpei Taniguchi, Tatsuo Masuda, Yoshinori Iwatani, Kenichi Yamamoto, Osaka Twin Research Group, Norio Sakai, Yukinori Okada, Mikio Watanabe

Clinical Genetics　Vol. 105　No. 2　p. 159-172　2023/10/29　Research paper (scientific journal)

Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases

Haruka Ozaki, Naoya Inoue, Yoshinori Iwatani, Ayano Watanabe, Mayu Yamamoto, Nozomi Kitahara, Shohei Tanikawa, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

Clinical Endocrinology　Vol. 99　No. 1　p. 103-112　2023/04/26　Research paper (scientific journal)

Twin Study: Genetic and Epigenetic Factors Affecting Circulating Adiponectin Levels

Mika Hasegawa, Jumpei Taniguchi, Hiromichi Ueda, Mikio Watanabe

The Journal of Clinical Endocrinology & Metabolism　Vol. 108　No. 1　p. 144-154　2023/01　Research paper (scientific journal)

Polymorphisms in Vitamin A-Related Genes and Their Functions in Autoimmune Thyroid Disease

Hinako Homma, Mikio Watanabe, Naoya Inoue, Moeko Isono, Yoh Hidaka, Yoshinori Iwatani

Thyroid　Vol. 31　No. 11　p. 1749-1756　2021/11/01　Research paper (scientific journal)

PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves’ and Hashimoto’s diseases

Mayumi Kawabata, Naoya Inoue, Mikio Watanabe, Ayaka Kobayashi, Yoh Hidaka, Akira Miyauchi, Yoshinori Iwatani

Autoimmunity　Vol. 54　No. 7　p. 450-459　2021/10/03　Research paper (scientific journal)

編集委員会への挑戦：生成AIで臨床化学の未来を考える

渡邉幹夫

臨床化学　Vol. 54　No. 3　p. 174-175　2025/07/31

Analyzing Clinical Laboratory Values Using Twin Research

Mikio WATANABE

The Journal of Japanese Society of Laboratory Medicine　Vol. 76　No. 6　p. 445-450　2025/06　Research paper (scientific journal)

Increased expression of membrane-bound TGF-β1, GITR, and GITR ligand in patients with autoimmune thyroid disease

Fumiaki Hayashi, Naoya Inoue, Yoshinori Iwatani, Yuka Yamashita, Hiroya Yamada, Akira Miyauchi, Mikio Watanabe

Immunology Letters　p. 107036-107036　2025/05　Research paper (scientific journal)

Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins.

Yoichi Takenaka, Osaka Twin Research Group, Mikio Watanabe

Epigenomes　Vol. 8　No. 4　2024/11/21　Research paper (scientific journal)

The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells

Yuya Arakawa, Yuzuki Tano, Moe Fujii, Yuuki Imai, Yoshiaki Norimatsu, Masaki Yasukawa, Mikio Watanabe, Takeshi Yamada

Cytokine　Vol. 175　p. 156506-156506　2024/03　Research paper (scientific journal)

Tofogliflozin attenuates renal lipid deposition and inflammation <i>via</i> PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Endocrine Journal　2024　Research paper (scientific journal)

Cap Analysis of Gene Expression Clarifies Transcriptomic Divergence Within Monozygotic Twin Pairs

Hirokazu Katoh, Hiroaki Asai, Keiko Takemoto, Rie Tomizawa, Chika Honda, Mikio Watanabe, Osaka Twin Research Group, Tomoyuki Honda

Twin Research and Human Genetics　Vol. 26　No. 4-5　p. 269-276　2023/08　Research paper (scientific journal)

Twin research shows glycan changes are more susceptible to environmental factors than their carrier glycoproteins

Tatsuya Asuka, Yoshihiro Kamada, Koichi Morishita, Tomoya Fukuoka, Shinji Takamatsu, Jumpei Kondo, Mikio Watanabe, Norio Sakai, Kazuo Hayakawa, Eiji Miyoshi

Glycoconjugate Journal　Vol. 40　No. 2　p. 191-198　2023/02/14　Research paper (scientific journal)

Multiplexed Measurement of Cell Type-specific Calcium Kinetics using High-content Image Analysis Combined with Targeted Gene Disruption.

Tabata, T, Masumura, Y, Higo, S, Kunimatsu, S, Kameda, S, Inoue, H, Okuno, S, Ogawa, S, Takashima, S, Watanabe, M, Miyagawa, S, Hikoso, S, Sakata, Y

Biochem Biophys Res Com　2022/11　Research paper (scientific journal)

HIF-1α regulates mTOR signaling pathway during salivary gland development

Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai

Biochemical and Biophysical Research Communications　Vol. 631　p. 130-137　2022/11　Research paper (scientific journal)

一卵性双生児におけるLDL-C変動要因の検討

西原 紗恵, 小関 正博, 田中 克尚, 尾松 卓, 冠野 昂太郎, 岡田 健志, 嵯峨 礼美, 朝治 真澄, 乾 洋勉, 大濱 透, 西田 誠, 坂田 泰史, 渡邉 幹夫

日本動脈硬化学会総会プログラム・抄録集　Vol. 54回　p. 233-233　2022/07　Research paper (other academic)

Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret I. Boomsma, Thorkild I. A. Sørensen, Tellervo Korhonen, Jaakko Kaprio

Scientific Reports　Vol. 12　No. 1　2022/07　Research paper (scientific journal)

The HIF‐1α pathway plays a critical role in salivary gland development in ex vivo organ cultures

Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai

FEBS Open Bio　Vol. 12　No. 2　p. 460-469　2022/02　Research paper (scientific journal)

Genetic influences on brain representations of natural audiovisual experiences

Satoshi Nishida, Shunsuke Toyoda, Chika Honda, Mikio Watanabe, Miina Ollikainen, Eero Vuoksimaa, Jaakko Kaprio, Shinji Nishimoto

2021/09/24

Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy

Isao Suetake, Shigeaki Nakazawa, Kazunobu Sato, Risa Mutoh, Yuichi Mishima, Toru Kawakami, Toshiki Takei, Mikio Watanabe, Norio Sakai, Toshimichi Fujiwara, Takeji Takui, Makoto Miyata, Akira Shinohara, Hironobu Hojo, Toshiaki Arata

Biochemical and Biophysical Research Communications　Vol. 567　p. 42-48　2021/08　Research paper (scientific journal)

Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins

Natsuko Matsumoto, Jonguk Park, Rie Tomizawa, Hitoshi Kawashima, Koji Hosomi, Kenji Mizuguchi, Chika Honda, Ritsuko Ozaki, Yoshinori Iwatani, Mikio Watanabe, Jun Kunisawa

Medicina　Vol. 57　No. 3　p. 275-275　2021/03/16　Research paper (scientific journal)

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Antti Latvala, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Esther Rebato, Andreas Busjahn, Jessica Tyler, John L. Hopper, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Lucas Calais-Ferreira, Vinicius C. Oliveira, Paulo H. Ferreira, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Sisira H. Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Glen E. Duncan, Dedra Buchwald, Per Tynelius, Finn Rasmussen, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Amie E. Hwang, Thomas M. Mack, Robert F. Krueger, Matt McGue, Shandell Pahlen, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Gonneke Willemsen, Meike Bartels, Catharina E. M. van Beijsterveldt, Carol E. Franz, William S. Kremen, Michael J. Lyons, Judy L. Silberg, Hermine H. Maes, Christian Kandler, Tracy L. Nelson, Keith E. Whitfield, Robin P. Corley, Brooke M. Huibregtse, Margaret Gatz, David A. Butler, Adam D. Tarnoki, David L. Tarnoki, Hang A. Park, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Yoshie Yokoyama, Thorkild I. A. Sørensen, Dorret I. Boomsma, Jaakko Kaprio

Scientific Reports　Vol. 10　No. 1　p. 12681-12681　2020/12　Research paper (scientific journal)

Up-To-Date Laboratory Tests of Autoimmune diseases

Mikio WATANABE

Rinsho-Byori　Vol. 68　No. 12　p. 989-993　2020/12　Research paper (scientific journal)

Heritability and Environmental Correlation of Phase Angle with Anthropometric Measurements: A Twin Study

Daisuke Matsumoto, Fujio Inui, Chika Honda, Rie Tomizawa, Mikio Watanabe, Karri Silventoinen, Norio Sakai

International Journal of Environmental Research and Public Health　Vol. 17　No. 21　p. 7810-7810　2020/10/26　Research paper (scientific journal)

Combination of multicolor flow cytometry for circulating lymphoma cells and tests for the RHOAG17V and IDH2R172 hot-spot mutations in plasma cell-free DNA as liquid biopsy for the diagnosis of angioimmunoblastic T-cell lymphoma

Masahiko Hayashida, Fumiyo Maekawa, Yoshinari Chagi, Futoshi Iioka, Yoichiro Kobashi, Mikio Watanabe, Hitoshi Ohno

Leukemia & Lymphoma　Vol. 61　No. 10　p. 2389-2398　2020/08/23　Research paper (scientific journal)

Increases of CD80 and CD86 expression on peripheral blood cells and their gene polymorphisms in autoimmune thyroid disease.

Watanabe, A, Inoue, N, Watanabe, M, Yamamoto, M, Ozaki, H, Hidaka, Y, Iwatani, Y

Immunological Investigation　Vol. 49　No. 1-2　p. 191-203　2020/02　Research paper (scientific journal)

Association of CD58 polymorphisms and its protein expression with the development and prognosis of autoimmune thyroid diseases.

Yamamoto, M, Watanabe, M, Inoue, N, Watanabe, A, Ozaki, H, Ohsaki, M, Yidaka, Y, Iwatani, Y

Immunological Investigations　Vol. 49　No. 1-2　p. 106-119　2020/02　Research paper (scientific journal)

Gene polymorphisms of VEGF and VEGFR2 are associated with the severity of Hashimoto’s disease and the intractability of Graves’ disease, respectively

Mami Okamoto, Mikio Watanabe, Naoya Inoue, Kazane Ogawa, Yoh Hidaka, Yoshinori Iwatani

Endocrine Journal　Vol. 67　No. 5　p. 545-559　2020　Research paper (scientific journal)

Opinion "Foster a sense of mission"

Watanabe, Mikio

Japanese Journal of Clinical Chemistry　Vol. 49　No. 1　p. 51-51　2020/01

In tube immunocytochemistry for fluorescence-activated cell sorting that prevents RNA degradation in sorted cells.

Fukano, H, Takano, T, Fujimoto, Y, Nakatani, R, Watanabe, M, Hidaka, Y, Shimomura, I

Biotech Histochem　Vol. 95　No. 1　p. 1-7　2020/01　Research paper (scientific journal)

Update on Osaka University Twin Registry: An Overview of Multidisciplinary Research Resources and Biobank at Osaka University Center for Twin Research

Honda, C, Watanabe, M, Tomizawa, R, Osaka Twin, Research Group, Sakai, N

Twin Res Hum Genet　Vol. 22　No. 6　p. 1-5　2019/12　Research paper (scientific journal)

Enhanced processivity of Dnmt1 by mono-ubiquitinated histone H3

Mishima, Y, Brueckner, L, Takahashi, S, Kawakami, T, Otani, J, Shinohara, A, Takeshita, K, Garvilles, R, Watanabe, M, Sakai, N, Takeshima, H, Nachtegael, C, Nishiyama, A, Nakanishi, M, Arita, K, Nakashima, K, Hojo, H, Suetake, I

Genes to Cells　Vol. 25　No. 1　2019/11　Research paper (scientific journal)

Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases

Hirai, N, Watanabe, M, Inoue, N, Kishonita, R, Ohtani, H, Hidaka, Y, Iwatani, Y

Autoimmunity　Vol. 52　No. 7-8　p. 191-203　2019/11　Research paper (scientific journal)

Association of IFNG gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid disease

Hashimoto, H, Watanabe, M, Inoue, N, Hirai, N, Haga, E, Kinoshita, R, Hidaka, Y, Iwatani, Y

Cytokine　Vol. 123　p. 154770-154770　2019/10　Research paper (scientific journal)

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.

Silventoinen K

Twin Res Hum Genet　Vol. 22　No. 6　p. 800-808　2019/08　Research paper (scientific journal)

Fault classification with discriminant analysis during sit-to-stand movement assisted by a nursing care robot

Tianyi Wang, Hieyong Jeong, Mikio Watanabe, Yoshinori Iwatani, Yuko Ohno

Mechanical Systems and Signal Processing　Vol. 113　p. 90-101　2018/12　Research paper (scientific journal)

Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease

Kunisato, T, Watanabe, M, Inoue, N, Okada, A, Nanba, T, Kobayashi, W, Inoue, Y, Katsumata, Y, Omori, N, Nobuhara, T, Takemura, K, Hidaka, Y, Iwatani, Y

Autoimmunity　Vol. 51　No. 7　p. 360-369　2018/11　Research paper (scientific journal)

Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases

Omori, N, Watanabe, M, Inoue, N, Taniguchi, J, Hidaka, Y, Iwatani, Y

Endocrine J　Vol. 65　No. 8　p. 815-826　2018/08　Research paper (scientific journal)

Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases

Naoya Inoue, Mikio Watanabe, Yuka Katsumata, Naoko Ishido, Yoh Hidaka, Yoshinori Iwatani

Immunological Investigations　Vol. 47　No. 5　p. 534-542　2018/07/04　Research paper (scientific journal)

Association of current and former smoking with body mass index: a study of smoking discordant twin pairs from 21 twin cohorts

Piirtola, N, Jelenkovic, A, Latvala, A, Sund. R, Honda, C, Inui, F, Watanabe, M, Tomizawa, R, Iwatani, Y

PLOS ONE　Vol. 17　No. 7　2018/07　Research paper (scientific journal)

Mean platelet component and mean platelet volume are the useful screening markers of myelodysplastic syndrome.

Masutani, R, Ikemoto, T, Maki, A, Tanada, H, Iwatani, Y, Watanabe, M, Takubo, T, Okada, Y

Health Science Reports　Vol. 1　No. 5　2018/05　Research paper (scientific journal)

Methylation levels of the TNFA gene are different between Graves’ and Hashimoto’s diseases and influenced by the TNFA polymorphism

Emi Morita, Mikio Watanabe, Naoya Inoue, Hidemi Hashimoto, Emi Haga, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 51　No. 3　p. 118-125　2018/04/03　Research paper (scientific journal)

論文紹介（gamma-delta T cells enhance B cells for antibody production in Hashimoto's thyroiditis, and Retinoic acid induces apoptosis for the gamma-delta T cell）

本間日向子, 渡邉幹夫

日本甲状腺学会雑誌　Vol. 9　No. 1　p. 86-86　2018/04

Twin study is an essential research method to clarify the crucial genetic and environmental factors for human phenotypes

Honda, C, Watanabe, M, Iwatani, Y

Gene & Medicine MOOK　No. 33　p. 49-51　2018/04

Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases

Ena Tokiyoshi, Mikio Watanabe, Naoya Inoue, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 51　No. 1　p. 35-42　2018/01/02　Research paper (scientific journal)

Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution

Araki T, Onishi M, Yanagisawa T, Hirata M, Watanabe Y, Ogata S, Hayakawa K, Honda C, Watanabe M, Iwatani Y, Yorifuji S

Scientific Reports　Vol. 7　No. 1　2017/12　Research paper (scientific journal)

Genotype-based epigenetic differences in monozygotic twins discordant for positive anti-thyroglobulin autoantibodies

Watanabe, M, Takenaka, Y, Honda, C, Osaka Twin, research Group, Iwatani, Y

Thyroid　Vol. 28　No. 1　p. 110-123　2017/12　Research paper (scientific journal)

認定試験と巡礼

渡邉幹夫

日本臨床検査同学院通信　Vol. 42　No. 4　p. 200-200　2017/12

Education in twins and their parents across birth cohorts over 100 years: an individual-level pooled analysis of 42 twin cohorts.

Silventoinen, K. Jelenkovic, A, Latvala, A, Sund, R, Yokoyama, Y, Ullemar, V, Almqvist, C, Derom, C.A, Vlietinck, R.F, Loos, R.JF, Kandler, C, Honda, C, Inui, F, Iwatani, Y, Watanabe, M

Twin Research and Humman Genetics　Vol. 20　No. 5　p. 395-405　2017/11　Research paper (scientific journal)

The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of TPOAb.

Tomari, S, Watanabe, M, Inoue, N, Mizuma, T, Yamanaka, C, Hidaka, Y, Iwatani, Y

Endocrine Journal　Vol. 64　No. 10　p. 1025-1032　2017/10　Research paper (scientific journal)

RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails

Yuichi Mishima, Laura Brueckner, Saori Takahashi, Toru Kawakami, Kyohei Arita, Shota Oka, Junji Otani, Hironobu Hojo, Masahiro Shirakawa, Akira Shinohara, Mikio Watanabe, Isao Suetake

FEBS JOURNAL　Vol. 284　No. 20　p. 3455-3469　2017/10　Research paper (scientific journal)

Thyroid hormone and autoimmune diseases

Watanabe, M

Journal of the Japan Thyroid Association　Vol. 8　No. 2　p. 147-155　2017/10

Thyroid hormone and autoimmune diseases

Watanabe, M

Journal of the Japan Thyroid Association　Vol. 8　No. 2　p. 161-169　2017/10

Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease

Tomoyo Mizuma, Mikio Watanabe, Naoya Inoue, Yuya Arakawa, Saki Tomari, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 50　No. 6　p. 386-392　2017/09　Research paper (scientific journal)

Association of IL-10-Regulating MicroRNAs in Peripheral Blood Mononuclear Cells with the Pathogenesis of Autoimmune Thyroid Disease.

Takuse, Y, Watanabe, M, Inoue, N, Ozaki, R, Otsu, H, Saeki, M, Katsumata, Y, Hidaka, Y, Iwatani, Y

Immunological Investigation　Vol. 46　No. 6　p. 590-602　2017/08　Research paper (scientific journal)

Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases

Inoue, N, Watanabe, M, Nakaguchi, A, Ueda, A, Kawaguchi, H, Hidaka, Y, Iwatani, Y

Endocrine Journal　Vol. 64　No. 7　p. 695-703　2017/07　Research paper (scientific journal)

Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Rie Tomizawa, Kirsi H. Pietilainen, Aila Rissanen, Sisira H. Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Maarit Piirtola, Sari Aaltonen, Sevgi Y. Oncel, Fazil Aliev, Esther Rebato, Jacob B. Hjelmborg, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Judy L. Silberg, Lindon J. Eaves, Tessa L. Cutler, Juan R. Ordonana, Juan F. Sanchez-Romera, Lucia Colodro-Conde, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E. Franz, William S. Kremen, Michael J. Lyons, Andreas Busjahn, Tracy L. Nelson, Keith E. Whitfield, Christian Kandler, Kerry L. Jang, Margaret Gatz, David A. Butler, Maria A. Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E. Duncan, Dedra Buchwald, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Hoe-Uk Jeong, Gary E. Swan, Ruth Krasnow, Patrik Ke Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Tom A. McAdams, Thalia C. Eley, Alice M. Gregory, Per Tynelius, Laura A. Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Timothy D. Spector, Massimo Mangino, Genevieve Lachance, S. Alexandra Burt, Kelly L. Klump, Jennifer R. Harris, Ingunn Brandt, Thomas S. Nilsen, Robert F. Krueger, Matt Mcgue, Shandell Pahlen, Robin P. Corley, Brooke M. Huibregtse, Meike Bartels, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Jack H. Goldberg, Finn Rasmussen, Adam D. Tarnoki, David L. Tarnoki, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, John L. Hopper, Joohon Sung, Hermine H. Maes, Eric Turkheimer, Dorret I. Boomsma, Thorkild I. A. Sorensen, Jaakko Kaprio

The American Journal of Clinical Nutrition　Vol. 106　No. 2　p. 457-466　2017/07　Research paper (scientific journal)

Polymorphisms in and expression of Toll-like receptors in autoimmune thyroid diseases

Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 50　No. 3　p. 182-191　2017/06　Research paper (scientific journal)

The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease

Yuya Arakawa, Mikio Watanabe, Kazuya Takemura, Naoya Inoue, Yoh hidaka, Yoshinori Iwatani

International Journal of Immunogenetics　Vol. 44　No. 2　p. 41-50　2017/05　Research paper (scientific journal)

Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases

Hiroshi Otsu, Mikio Watanabe, Naoya Inoue, Ryota Masutani, Yoshinori Iwatani

Clinical Chemistry and Laboratory Medicine　Vol. 55　No. 5　p. 626-635　2017/05/01　Research paper (scientific journal)

TSHR gene polymorphisms in the enhancer regions are most strongly associated with the development of Graves' disease, especially intractable disease, and with that of Hashimoto's disease

Asami Fujii, Naoya Inoue, Mikio Watanabe, Chisa Kawakami, Yoh Hidaka, Yoshihide Hayashizaki, Yoshinori Iwatani

Thyroid　Vol. 27　No. 1　p. 111-119　2017/01　Research paper (scientific journal)

Optimization of recovery and analysis of RNA in sorted cells in mRNA quantification after fluorescence-activated cell sorting.

Maeda, T, Date, A, Watanabe, M, Hidaka, Y, Iwatani, Y, Takano, T

Ann Clin Lab Sci　Vol. 46　No. 6　p. 435-441　2016/12　Research paper (scientific journal)

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Jelenkovic, A, Hur, Y, Sund, R

eLife　Vol. 5　2016/12　Research paper (scientific journal)

DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases

Minori Saeki, Mikio Watanabe, Naoya Inoue, Ena Tokiyoshi, Yukina Takuse, Yuya Arakawa, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 49　No. 8　p. 514-522　2016/12　Research paper (scientific journal)

Language-related cerebral oscillatory changes are influenced equally by genetic and environmental factors

Toshihiko Araki, Osaka Twin Research Group, Masayuki Hirata, Takufumi Yanagisawa, Hisato Sugata, Mai Onishi, Yoshiyuki Watanabe, Soshiro Ogata, Chika Honda, Kazuo Hayakawa, Shiro Yorifuji, Yoshinori Iwatani, Norio Sakai, Kei Kamide, Shinji Kihara, Kiyoko Makimoto, Hiroko Watanabe, Jun Hatazawa, Masanori Takahashi, Mikio Watanabe, Chika Honda, Rie Tomizawa

NeuroImage　Vol. 142　p. 241-247　2016/11/15　Research paper (scientific journal)

Optimization of Recovery and Analysis of RNA in Sorted Cells in mRNA Quantification After Fluorescence-activated Cell Sorting

Tomoko Maeda, Arisa Date, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

ANNALS OF CLINICAL AND LABORATORY SCIENCE　Vol. 46　No. 6　p. 571-577　2016/11　Research paper (scientific journal)

Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases

Inoue, N, Watanabe, M, Ishido, N, Kodu, A, Maruoka, H, Katsumata, Y, Hidaka, Y, Iwatani, Y

Hum Immunol　Vol. 77　No. 10　p. 944-951　2016/10　Research paper (scientific journal)

Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs.

Watanabe, M, Honda, C, The Osaka Twin, Research Group, Iwatani, Y

BMC Medical Genomics　Vol. 9　p. 55-63　2016/09　Research paper (scientific journal)

Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs.

Watanabe, M, Honda, C, The Osaka Twin, Research Group, Iwatani, Y

BMC Medical Genomics　Vol. 9　p. 55-63　2016/09　Research paper (scientific journal)

考える臨床検査―スクリーニング検査で異常値をみたら？―

渡邉幹夫

臨床検査学教育　Vol. 8　No. 2　p. 229-229　2016/08

Association of the polymorphisms of chemokine genes (IL8, RANTES, MIG, IP10, MCP1 and IL16) with the pathogenesis of autoimmune thyroid diseases

Maiko Akahane, Mikio Watanabe, Naoya Inoue, Yumi Miyahara, Yuya Arakawa, Yuka Inoue, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 49　No. 5　p. 312-319　2016/08　Research paper (scientific journal)

Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease

Mika Sarumaru, Mikio Watanabe, Naoya Inoue, Yuko Hisamoto, Emi Morita, Yuya Arakawa, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 49　No. 5　p. 329-337　2016/08　Research paper (scientific journal)

Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto's disease. Endocrin J (in press) Sarumaru, M., Watanab

Kagawa, T, Watanabe, M, Inoue, N, Otsu, H, Saeki, M, Katsumata, Y, Takuse, Y, Iwatani, Y

Endocrine Journal　Vol. 63　No. 4　p. 375-380　2016/04　Research paper (scientific journal)

Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases

Yoshie, N, Watanabe, M, Inoue, N, Kawaguchi, H, Hidaka, Y, Iwatani, Y

Endocrine Journal　Vol. 63　No. 1　p. 61-68　2016/01　Research paper (scientific journal)

自己免疫性甲状腺疾患の病態とIL15遺伝子に存在する一塩基多型との関連

荒川 裕也, 渡邉 幹夫, 武村 和哉, 岩谷 良則

臨床化学　Vol. 44　No. Suppl.1　p. 205-205　2015/10

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.

Jelenkovic A, Yokoyama Y, Sund R, Honda C, Bogl LH, Aaltonen S, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Tarnoki AD, Tarnoki DL, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Kim B, Chong Y, Hong C, Shin HJ, Christensen K, Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK

Twin Res Hum Genet　Vol. 18　No. 5　p. 557-570　2015/10　Research paper (scientific journal)

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D. Tarnoki, David L. Tarnoki, Feng Ning, Fuling Ji, Zengchang Pang, Juan R. Ordonana, Juan F. Sanchez-Romera, Lucia Colodro-Conde, S. Alexandra Burt, Kelly L. Klump, Sarah E. Medland, Grant W. Montgomery, Christian Kandler, Tom A. McAdams, Thalia C. Eley, Alice M. Gregory, Kimberly J. Saudino, Lise Dubois, Michel Boivin, Claire M. A. Haworth, Robert Plomin, Sevgi Y. Oncel, Fazil Aliev, Maria A. Stazi, Corrado Fagnani, Cristina D'Ippolito, Jeffrey M. Craig, Richard Saffery, Sisira H. Siribaddana, Matthew Hotopf, Athula Sumathipala, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A. Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L. Freitas, Jose Antonio Maia, K. Paige Harden, Elliot M. Tucker-Drob, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Changhee Hong, Youngsook Chong, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L. Silberg, Lindon J. Eaves, Hermine H. Maes, Tessa L. Cutler, John L. Hopper, Kelly Aujard, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A. Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkila, Qihua Tan, Dongfeng Zhang, Gary E. Swan, Ruth Krasnow, Kerry L. Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F. Krueger, Matt Mcgue, Shandell Pahlen, Per Tynelius, Glen E. Duncan, Dedra Buchwald, Robin P. Corley, Brooke M. Huibregtse, Tracy L. Nelson, Keith E. Whitfield, Carol E. Franz, William S. Kremen, Michael J. Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos C. E. M. van Beijsterveldt, Jane Wardle, Clare H. Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G. Martin, Yoshinori Iwatani, Kazuo Hayakawa, Finn Rasmussen, Joohon Sung, Jennifer R. Harris, Gonneke Willemsen, Andreas Busjahn, Jack H. Goldberg, Dorret I. Boomsma, Yoon-Mi Hur, Thorkild I. A. Sorensen, Jaakko Kaprio

TWIN RESEARCH AND HUMAN GENETICS　Vol. 18　No. 4　p. 348-360　2015/08　Research paper (scientific journal)

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.

Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, Tarnoki AD, Tarnoki DL, Ning F, Ji F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Medland SE, Montgomery GW, Kandler C, McAdams TA, Eley TC, Gregory AM, Saudino KJ, Dubois L, Boivin M, Haworth CM, Plomin R, Öncel SY, Aliev F, Stazi MA, Fagnani C, D'Ippolito C, Craig JM, Saffery R, Siribaddana SH, Hotopf M, Sumathipala A, Spector T, Mangino M, Lachance G, Gatz M, Butler DA, Bayasgalan G, Narandalai D, Freitas DL, Maia JA, Harden KP, Tucker-Drob EM, Christensen K, Skytthe A, Kyvik KO, Hong C, Chong Y, Derom CA, Vlietinck RF, Loos RJ, Cozen W, Hwang AE, Mack TM, He M, Ding X, Chang B, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Aujard K, Magnusson PK, Pedersen NL, Aslan AK

Twin Res Hum Genet　Vol. 27　No. 4　p. 1-13　2015/04　Research paper (scientific journal)

Association between functional polymorphisms in the toll-like receptor 4 (TLR4) gene and HD severity.

Naoya Inoue, Mikio Watanabe, Yuka Katsumata, Naoko Ishido, Yoh Hidaka, Yoshinori Iwatani

Tissue Antigens　Vol. 85　No. 3　p. 209-211　2015/03　Research paper (scientific journal)

The Relationship between Skewed X Chromosome Inactivation and the Prognosis of Graves' and Hashimoto's Diseases

Naoko Ishido, Naoya Inoue, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani

Thyroid　Vol. 25　No. 2　p. 256-261　2015/02　Research paper (scientific journal)

Expression Analysis of Stemness Genes in a Rat Thyroid Cell Line FRTL5.

Asami Shimasue, Noriko Yamakawa, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

Exp Clin Endocrinol Diabetes　Vol. 123　No. 1　p. 48-54　2015/01　Research paper (scientific journal)

Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases

Y. Inoue, M. Watanabe, N. Inoue, T. Kagawa, S. Shibutani, H. Otsu, M. Saeki, Y. Takuse, Y. Hidaka, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 178　No. 2　p. 229-235　2014/11　Research paper (scientific journal)

The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases

Naoya Inoue, Mikio Watanabe, Naoko Ishido, Yuka Katsumata, Tomoya Kagawa, Yoh Hidaka, Yoshinori Iwatani

Clinical and Experimental Immunology　Vol. 178　No. 2　p. 262-269　2014/11　Research paper (scientific journal)

Associations of single nucleotide polymorphisms in pri-miR-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases.

Yuka Inoue, Mikio Watanabe, Naoya Inoue, Tomoya Kagawa, Sayaka Shibutani, Hiroshi Otsu, Minori Saeki, Yukina Takuse, Yoh Hidaka, Yoshinori Iwatani

Clinical and Experimental Immunology　Vol. 178　No. 2　p. 229-235　2014/11　Research paper (scientific journal)

An improved protocol for mRNA quantification after fluorescence-activated cell sorting with an increased signal to noise ratio in flow cytometry.

Arisa Date, Tokoko Maeda, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

Molecular biotechnology　Vol. 56　No. 7　p. 591-598　2014/07　Research paper (scientific journal)

Genome-wide association study and its application to thyroid diseases

Mikio Watanabe

Journal of the Japan Thyroid Association　Vol. 5　No. 1　p. 9-13　2014/04

The GG genotype of the -1125G/T polymorphism in the EPO gene protects against the development of Graves' disease

Naoya Inoue, Mikio Watanabe, Takayuki Nobuhara, Yoh Hidaka, Yoshinori Iwatani

Immunology Letters　Vol. 56　No. 1-2　p. 156-158　2013/12　Research paper (scientific journal)

Different genotypes of a functional polymorphism of the TSHR gene are associated with the development and severity of Graves' and Hashimoto's diseases

N. Inoue, M. Watanabe, Y. Katsumata, Y. Hidaka, Y. Iwatani

Tissue Antigens　Vol. 82　No. 4　p. 288-290　2013/10　Research paper (scientific journal)

IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease

Naoya Inoue, Mikio Watanabe, Megumi Wada, Mami morita, Yoh Hidaka, Yoshinori Iwatani

Cytokine　Vol. 64　No. 1　p. 370-374　2013/07　Research paper (scientific journal)

Preparation of thyroid follicular cells for mRNA quantification after fluorescence-activated cell sorting

Chisa Matsumoto, Mitsuru Ito, Hiroya Yamada, Hiroshi Yoshida, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Akira Miyauch, Toru Takano

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION　Vol. 73　No. 3　p. 245-252　2013/04　Research paper (scientific journal)

The association between a functional polymorphism in the CD24 gene and the development of autoimmune thyroid diseases

Inoue, N, Watanabe, M, Hayashi F, Hidaka, Y, Iwatani, Y

Tissue Antigen　Vol. 81　No. 3　p. 161-163　2013/03　Research paper (scientific journal)

Genes that characterize T3-predominant Graves' thyroid tissues

Matsumoto, C, Ito, M, Yamada, H, Yamakawa, N, Yoshida, H, Date, A, Watanabe, M, Hidaka, Y, Iwatani, Y, Miyauchi, A, Takano, T

Europian Journal of Endocrinology　Vol. 168　No. 2　p. 137-144　2013/02　Research paper (scientific journal)

Interference by Pralidoxime (PAM) salts in clinical laboratory tests.

Nagase, S, Kohguchi, K, Tohyama, K, Watanabe, M, Iwatani, Y

Clinical Chimical Acta　2013/01　Research paper (scientific journal)

Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies

Naoya Inoue, Mikio Watanabe, Hiroya Yamada, Kazuya Takemura, Fumiaki Hayashi, Noriko Yamakawa, Maiko Akahane, Yu Shimizuishi, Yoh Hidaka, Yoshinori Iwatani

Journal of Clinical Immunology　Vol. 32　No. 6　p. 1243-1252　2012/12　Research paper (scientific journal)

Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease

Y. Arakawa, M. Watanabe, N. Inoue, M. Sarumaru, Y. Hidaka, Y. Iwatani

Clinical and Experimental Immunology　Vol. 170　No. 2　p. 194-201　2012/11　Research paper (scientific journal)

Prolonged hybridization with a cRNA probe improves the signal to noise ratio for in-tube in situ hybridization for quantification of mRNA after fluorescence-activated cell sorting

H. Yamada, N. Yamakawa, M. Watanabe, Y. Hidaka, Y. Iwatani, T. Takano

Biotechnic and Histochemistry　Vol. 87　No. 5　p. 366-371　2012/07　Research paper (scientific journal)

Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease

Mami Morita, Mikio Watanabe, Naoya Inoue, Chisa Inaoka, Takashi Akamizu, Ke-Ita Tatsumi, Yoh Hidaka, Yoshinori Iwatani

Autoimmunity　Vol. 45　No. 2　p. 129-136　2012/03　Research paper (scientific journal)

A solution for distinguishing Le(a-b-) sera in CA19-9 assays using SphereLight 180 and Architect i2000 assays

Hiroyuki Hanada, Satomi Mugii, Keiko Takeoka, Ikuhiro Maeda, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani

Clinica Chimica Acta　Vol. 413　No. 1-2　p. 278-281　2012/01/18　Research paper (scientific journal)

Measurement of TFF3 mRNA in aspirates from thyroid nodules using mesh filtration: The first clinical trial in 130 cases

Hiroya Yamada, Toru Takano, Minoru Kihara, Mitsuyoshi Hirokawa, Hiroshi Yoshida, Mikio Watanabe, Yoshinori Iwatani, Yoh Hidaka, Akira Miyauchi

Endocrine Journal　Vol. 59　No. 7　p. 621-630　2012　Research paper (scientific journal)

Association of functional GITR gene polymorphisms related to expression of GITR molecules with prognosis of autoimmune thyroid disease

Rie Tomizawa, Mikio Watanabe, Naoya Inoue, Kazuya Takemura, Yoh Hidaka, Takashi Akamizu, Kazuo Hayakawa, Yoshinori Iwatani

Clinical and Experimental Immunology　2011/05　Research paper (scientific journal)

Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases

N. Inoue, M. Watanabe, M. Morita, K. Tatusmi, Y. Hidaka, T. Akamizu, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 163　No. 3　p. 318-323　2011/03　Research paper (scientific journal)

臨床検査技師にこそ情報教育を！（臨床検査技師教育機関からの声）

渡邉幹夫

大臨技ニュース　2011/02

Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines

Hiroya Yamada, Toru Takano, Fumio Matsuzuka, Mikio Watanabe, Akira Miyauchi, Yoshinoroi Iwatani

Genetics and Molecular Biology　Vol. 34　No. 1　p. 6-10　2011/01　Research paper (scientific journal)

mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes

Rie Maruo, Hiroya Yamada, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

Molecular Biotechnology　Vol. 49　p. 42-47　2011/01　Research paper (scientific journal)

Transcriptional activity of the 5 '-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines

Hiroya Yamada, Toru Takano, Fumio Matsuzuka, Mikio Watanabe, Akira Miyauchi, Yoshinori Iwatani

GENETICS AND MOLECULAR BIOLOGY　Vol. 34　No. 1　p. 6-10　2011　Research paper (scientific journal)

mRNA quantification after fluorescence activated cell sorting using locked nucleic acid probes

Rie Maruo, Hiroya Yamada, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

Molecular Biotechnology　2011/01　Research paper (scientific journal)

第5回日本臨床検査学教育学会学術大会教員研修会レポート（遺伝子検査学分野）

渡邉幹夫, 奥宮敏可

Medical Technology　2010/12

Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases

N. Inoue, M. Watanabe, M. Morita, R. Tomizawa, T. Akamizu, K. Tatsumi, Y. Hidaka, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 162　No. 3　p. 402-406　2010/12　Research paper (scientific journal)

Messenger RNA quantification after fluorescence activated cell sorting using in situ hybridization

Hiroya Yamada, Rie Maruo, Mikio Watanabe, Yoh Hidaka, Yoshinri Iwatani, Toru Takano

Cytometry Part A　2010/11　Research paper (scientific journal)

Increases in urinary creatinine and blood pressure during early pregnancy in pre-eclampsia

Koichi Kuromoto, Mikio Watanabe, Kazushige Adachi, Kazutomo Ohashi, Yoshinori Iwatani

ANNALS OF CLINICAL BIOCHEMISTRY　Vol. 47　p. 336-342　2010/07　Research paper (scientific journal)

Messenger RNA quantification after fluorescence activated cell sorting using intracellular antigens

Hiroya Yamada, Rie Maruo, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani, Toru Takano

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 397　No. 3　p. 425-428　2010/07　Research paper (scientific journal)

第4回日本臨床検査学教育学会学術大会イブニングセミナー（遺伝子検査学）

奥宮敏可, 渡邉幹夫

Medical Technology　2010/03

Drug selection and Laboratory tests -Graves' disease-

Mikio Watanabe

The Yakuji Nippo Medical　2010/02

Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes

Shoko Kuroda, Mikio Watanabe, Tomoko Santo, Yu Shimizuishi, Toru Takano, Yoh Hidaka, Tadashi Kimura, Yoshinori Iwatani

ANNALS OF CLINICAL BIOCHEMISTRY　Vol. 47　p. 62-66　2010/01　Research paper (scientific journal)

Association of the-31C/T functional polymorphism in the interleukin-1 beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells

F. Hayashi, M. Watanabe, T. Nanba, N. Inoue, T. Akamizu, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 158　No. 3　p. 281-286　2009/12　Research paper (scientific journal)

Association of the-31C/T functional polymorphism in the interleukin-1 beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells

F. Hayashi, M. Watanabe, T. Nanba, N. Inoue, T. Akamizu, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 158　No. 3　p. 281-286　2009/12　Research paper (scientific journal)

Report from Academic Meeting -- The Japanese Society for Gene Diagnosis and Therapy

Mikio Watanabe

Japanese Journal of Medical Technology Education　2009/09

Early detection of metastasis and relapse of colorectal cancer by recognizing NCA-2 in commercially available CEA assay.

Hiroyuki Hanada, Satomi Mugii, Keiko Takeoka, Ikuhiro Maeda, Mikio Watanabe, Yoh Hidaka, Yoshinori Iwatani

Clinical Chemistry　2009/09　Research paper (scientific journal)

Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada, Toru Takano, Yasuhiro Ito, Fumio Matsuzuka, Akihiro Miya, Kaoru Kobayashi, Hiroshi Yoshida, Mikio Watanabe, Yoshinori Iwatani, Akira Miyauchi

CANCER LETTERS　Vol. 280　No. 1　p. 61-64　2009/07　Research paper (scientific journal)

Thyroid diseases during and after pregnancy

Mikio Watanabe, Yoshinori Iwatani

Sogo Rinsho　Vol. 58　No. 7　p. 1587-1591　2009/07

Increases of the Th1/Th2 Cell Ratio in Severe Hashimoto's Disease and in the Proportion of Th17 Cells in Intractable Graves' Disease

Takashi Nanba, Mikio Watanabe, Naoya Inoue, Yoshinori Iwatani

THYROID　Vol. 19　No. 5　p. 495-501　2009/05　Research paper (scientific journal)

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody

N. Inoue, M. Watanabe, T. Nanba, M. Wada, T. Akamizu, Y. Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 156　No. 2　p. 199-204　2009/05　Research paper (scientific journal)

Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan

Mifumi Kita, Matsuo Deguchi, Masanori Kagita, Nori Yoshioka, Eiji Kobayashi, Mikio Watanabe, Seishi Asari, Kiyoharu Yamanaka, Yoshinori Iwatani

Clinical Laboratory　Vol. 55　No. 1-2　p. 9-22　2009　Research paper (scientific journal)

Laboratory tests viewed in symptom - Weight loss -

Mikio Watanabe

The YAKUJI NIPPO MEDICAL　2008/11

Patients of Hashimto's disease with -599CC genotype in the IL4 gene would develop hypothyroidis

Mikio Watanabe, Takashi Nanba, Takashi Akamizu, Yoshinori Iwatani

2008/10

A Novel microfluidic immunoassay to determine AFP-L3% in serum samples.

Hanada, H, Kagebayashi, C, Kurosawa, T, Kawabata, T, Kitano, H, Li, C, Bousse, L, Watanabe, M, Maeda, I, Takeoka, K, Watanabe, M, Wada, H. G, Hidaka, Y, Iwatani, Y, Satomura, S

2008/07

A new predictive indicator for development of pressure ulcers in bedridden patients based on common laboratory tests results

N. Hatanaka, Y. Yamamoto, K. Ichihara, S. Mastuo, Y. Nakamura, M. Watanabe, Y. Iwatani

JOURNAL OF CLINICAL PATHOLOGY　Vol. 61　No. 4　p. 514-518　2008/04　Research paper (scientific journal)

The -590CC Genotype in Interleukin-4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto's Disease

Takashi Nanba, Mikio Watanabe, Takashi Akamizu, Yoshinori Iwatani

Clinical Chemistry　2008/03　Research paper (scientific journal)

The +869T/C polymorphism in the transforming growth factor-β1 gene is associated with the severity and intractability of autoimmune thyroid disease

H. Yamada, M. Watanabe, T. Nanba, T. Akamizu, Y. Iwatani

Clinical and Experimental Immunology　Vol. 151　No. 3　p. 379-382　2008/03　Research paper (scientific journal)

5種のHIVスクリーニング検査試薬の評価

喜多美文, 出口松夫, 鍵田正智, 吉岡範, 浅利誠志, 渡邉幹夫, 岩谷良則, 山中喜代治

日本臨床検査自動化学会会誌　2008/02　Research paper (scientific journal)

6種類のTreponema Pallidum(TP)抗体測定法の比較

吉岡範, 出口松夫, 鍵田正智, 田原和子, 喜多美文, 中野卓, 森恵子, 渡邉幹夫, 岩谷良則, 浅利誠志

日本臨床検査自動化学会会誌　2008/01　Research paper (scientific journal)

Decrease of intrathyroidal CD161+Vα24+Vβ 11+ NKT cells in Graves' disease

Mikio Watanabe, Yukiyo Nakamura, Fumio Matsuzuka, Yuuki Takamura, Akira Miyauchi, Yoshinori Iwatani

Endocrine Journal　Vol. 55　No. 1　p. 199-203　2008　Research paper (scientific journal)

Ratio of serum IgG3 to total IgG concentration ond goiter size are independent factors in intractability of Graves' disease.

Santoh, T, Watanabe, M, Kuroda, S, Ueda, D, Iwatani, Y

Endocrine Journal　Vol. 54　No. 6　p. 887-894　2007/12　Research paper (scientific journal)

Evaluation of a chemiluminescent microparticle immunoassay for determination of Treponema pallidum antibodies

Nori Yoshioka, Matsuo Deguchi, Masanori Kagita, Mifumi Kita, Mikio Watanabe, Seishi Asari, Yoshinori Iwatani

Clinical Laboratory　Vol. 53　No. 9-12　p. 597-603　2007/11　Research paper (scientific journal)

Study on physiology and psychological effect of lawn ground and lavender field in city park

IWASAKI Yutaka, YAMAMOTO Satoshi, ISHI Mayuko, WATANABE Mikio

Journal of the Japanese Society of Revegetation Technology　Vol. 33　No. 1　p. 116-121　2007/08/31　Research paper (scientific journal)

橋本病の発症機序

渡邉幹夫, 岩谷良則

内分泌・糖尿病科　2007/08

Clinical significance of CEA-family measurement as a marker for metastasis and relapse of cancer.

Hanada, H, Takeoka, K, Nomura, T, Yamashita, Y, Namba, T, Watanabe, M, Iwatani Y, Hidaka, Y

2007/07

化学発光酵素免疫測定法によるHCV core抗原測定法の評価

吉岡範, 出口松夫, 鍵田正智, 田原和子, 喜多美文, 中野卓, 渡邉幹夫, 岩谷良則, 浅利誠志

日本臨床検査自動化学会会誌　2007/05　Research paper (scientific journal)

化学発光免疫測定試薬「アーキテクトHBc-M」の基本性能と臨床的有用性の評価

喜多美文, 出口松夫, 鍵田正智, 吉岡 範, 浅利誠志, 渡邉幹夫, 岩谷良則, 山中喜代治

日本臨床検査自動科学会会誌　2007/03　Research paper (scientific journal)

化学発光免疫測定試薬「アーキテクトHBe AgおよびHBe Ab」の基本性能と臨床的有用性

喜多美文, 出口松夫, 鍵田正智, 吉岡 範, 浅利誠志, 渡邉幹夫, 岩谷良則, 山中喜代治

日本臨床検査自動化学会会誌　2007/01　Research paper (scientific journal)

Apoptosis-induced decrease of intrathyroidal CD4(+)CD25(+) regulatory T cells in autoimmune thyroid diseases

Aiko Nakano, Mikio Watanabe, Takao Iida, Shoko Kuroda, Fumio Matsuzuka, Akira Miyauchi, Yoshinori Iwatani

THYROID　Vol. 17　No. 1　p. 25-31　2007/01　Research paper (scientific journal)

HCV抗体測定における3種化学発光法の比較

吉岡範, 出口松夫, 鍵田正智, 中野卓, 田原和子, 笹原優香, 喜多美文, 渡邉幹夫, 岩谷良則, 浅利誠志

日本臨床検査自動化学会会誌　2006/11　Research paper (scientific journal)

Association between the severity of Hashimoto's disease and the functional +874A/T polymorphism in the interferon-gamma gene

Chisato Ito, Mikio Watanabe, Noriko Okuda, Chikami Watanabe, Yoshinori Iwatani

ENDOCRINE JOURNAL　Vol. 53　No. 4　p. 473-478　2006/08　Research paper (scientific journal)

オーソクイックチェイサーHCV AbによるC型肝炎ウイルス(HCV)抗体高力価判定基準の設定

喜多美文, 出口松夫, 鍵田正智, 浅利誠志, 渡邉幹夫, 岩谷良則, 山中喜代治

日本臨床検査自動化学会会誌　2006/02　Research paper (scientific journal)

Chemiluminescent Enzyme Immunoassay (CLEIA)による風疹ウィルス抗体測定の基礎的検討

吉岡範, 出口松夫, 鍵田正智, 中野卓, 田原和子, 笹原優香, 渡邉幹夫, 岩谷良則, 浅利誠志

日本臨床検査自動化学会会誌（JJCLA）　2006/02　Research paper (scientific journal)

Association between the severity of Hashimoto's disease and the functional +874A/T polymorphism in the interferon-γ gene

Chisato Ito, Mikio Watanabe, Noriko Okuda, Chikami Watanabe, Yoshinori Iwatani

Endocrine Journal　Vol. 53　No. 4　p. 473-478　2006　Research paper (scientific journal)

A useful new classification of dysmorphic urinary erythrocytes

Daisuke Nagahama, Kenichi Yoshiko, Mikio Watanabe, Yoshiki Morita, Yoshinori Iwatani, Seiichi Matsuo

Clinical and Experimental Nephrology　Vol. 9　No. 4　p. 304-309　2005/12　Research paper (scientific journal)

Study on the effects for human physiology from green in urban parks

Satoshi Yamamoto, Yutaka Iwasaki, Hyojung Kweon, Mikio Watanabe

Landscape Plannning & Horticulture　2005/03　Research paper (scientific journal)

Intrathyroidal CD4(+) T lymphocytes express high levels of Fas and CD4(+)CD8(+) macrophages/dendritic cells express fas ligand in autoimmune thyroid disease

Y Nakamura, M Watanabe, F Matsuzuka, H Maruoka, A Miyauchi, Y Iwatani

THYROID　Vol. 14　No. 10　p. 819-824　2004/10　Research paper (scientific journal)

大学教員の看護実習におけるストレスに対するコルチゾールを用いた評価

河上智香, 藤原千惠子, 渡邉幹夫, 石井京子, 多河典子, 小林吉晴

日本健康心理学会第17回大会　2004/09

Lower concentration of serum soluble CD8 in severe Hashimoto's disease

N Yamamoto, M Watanabe, F Matsuzuka, A Miyauchi, Y Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 137　No. 3　p. 601-605　2004/09　Research paper (scientific journal)

Effects of plant's aroma on anti-stress with Plant's leaf tearing task.

Iwasaki, Y, Yamamoto, S, Kweon, H, Watanabe, M, Asano, F

2004/06　Research paper (international conference proceedings)

Increased intensities of fas expression on peripheral T-cell subsets in severe autoimmune thyroid disease

H Maruoka, M Watanabe, F Matsuzuka, T Takimoto, A Miyauchi, Y Iwatani

THYROID　Vol. 14　No. 6　p. 417-423　2004/06　Research paper (scientific journal)

Decrease of CD154 intensity on peripheral CD4(+) T cells in autoimmune thyroid disease

M Watanabe, N Yamamoto, F Matsuzuka, A Miyauchi, Y Iwatani

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　Vol. 136　No. 3　p. 555-558　2004/06　Research paper (scientific journal)

Increase of serum Interleukin-10 in intractable Graves' disease.

Takeoka, K, Watanabe, M, Matsuzuka, F, Miyauchi, A, Iwatani, Y

Thyroid　Vol. 14　No. 3　p. 201-205　2004/03　Research paper (scientific journal)

Study on stress easing effect by aroma of revegetation trees in city

Yutaka Iwasaki, Satoshi Yamamoto, Mikio Watanabe

AROMA RESEARCH　Vol. 5　No. 4　p. 386-390　2004　Research paper (scientific journal)

Physiological changes of Fas expression in peripheral lymphocyte subsets during the menstrual cycle

R Shinoda, M Watanabe, Y Nakamura, H Maruoka, Y Kimura, Y Iwatani

JOURNAL OF REPRODUCTIVE IMMUNOLOGY　Vol. 60　No. 2　p. 159-168　2003/12　Research paper (scientific journal)

Basic study on human psychological and physiological characteristics in responses to existing plants in urban parks.

Yamamoto, S, Iwasaki, Y, Mino, N, Watanabe, M

Journal of the Japanese Institute of Landscape Architecture, International Edition, 2, 25-30, 2003　2003/10　Research paper (scientific journal)

High frequency of antibiotic-associated diarrhea due to toxin A-negative, toxin B-positive Clostridium difficile in a hospital in Japan and risk factors for infection

M Komatsu, H Kato, M Aihara, K Shimakawa, M Iwasaki, Y Nagasaka, S Fukuda, S Matsuo, Y Arakawa, M Watanabe, Y Iwatani

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES　Vol. 22　No. 9　p. 525-529　2003/09　Research paper (scientific journal)

Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in health care workers and evaluation of a vaccination program in a tertiary care hospital in Japan

S Asari, M Deguchi, K Tahara, M Taniike, M Toyokawa, Nishi, I, M Watanabe, Y Iwatani, K Makimoto

AMERICAN JOURNAL OF INFECTION CONTROL　Vol. 31　No. 3　p. 157-162　2003/05　Research paper (scientific journal)

Increase in immunoglobulin G3-secreting cells in intractable Graves' disease

Y Nakamoto, M Niki, M Watanabe, Y Iwatani

THYROID　Vol. 13　No. 4　p. 325-331　2003/04　Research paper (scientific journal)

Basic study on human psychological and physiological characteristics in responses to existing plants in urban parks

Yamamoto, S, Iwasaki, Y, Mino, N, Watanabe, M

2003/03　Research paper (bulletin of university, research institution)

Do Not Apply The Reference Values Of Labotarory Tests For Young To Elders

Mikio Watanabe

2003/03

Relation of CD30 molecules on T-cell subsets to the severity of autoimmune thyroid disease

M Watanabe, N Yamamoto, H Maruoka, F Matsuzuka, A Miyauchi, Y Iwatani

THYROID　Vol. 13　No. 3　p. 259-263　2003/03　Research paper (scientific journal)

Differential Diagnosis And Treatment Of Thyrotoxicosis

Mikio Watanabe

2002/08

Independent involvement of CD8+CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease

Mikio Watanabe, Naoko Yamamoto, Hayato Maruoka, Hajime Tamai, Fumio Matsuzuka, Akira Miyauchi, Yoshinori Iwatani

Thyroid　Vol. 12　No. 9　p. 801-808　2002　Research paper (scientific journal)

Increase of CD5+ B cells during adolescence in female mice

Kiyoshi Watanabe, Mikio Watanabe, Hayato Maruoka, Nobuyuki Amino, Yoshinori Iwatani

Mechanisms of Ageing and Development　Vol. 122　No. 15　p. 1787-1795　2001　Research paper (scientific journal)

Increased intensity of Fas expression on peripheral T cell subsets in severe autoimmune thyroid disease.

Mikio Watanabe, Hayato Maruoka, Naoko Yamamoto, Fumio Matsuzuka, Hajime Tamai, Takimoto, T, Kanji Kuma, Yoshinori Iwatani

2000/10

Atherosclerosis And CD40

Mikio Watanabe, Yoshinori Iwatani

1999/07

The maternal immune system in health and disease

Y Iwatani, M Watanabe

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY　Vol. 10　No. 6　p. 453-458　1998/12　Research paper (scientific journal)

Necessity Of Training For Using Computer Network With Manner

WATANABE Mikio

1998/10　Research paper (bulletin of university, research institution)

Free T4 And Free T3

Yoshinori Iwatani, Mikio Watanabe

1998/04

Lymphocyte Subsets

Mikio Watanabe, Yoshinori, Iwatani

1998/04

Opposite changes in serum soluble CD8 in patients at the active stages of Graves' and Hashimoto's diseases

M Watanabe, N Amino, K Hochito, K Watanabe, K Kuma, Y Iwatani

THYROID　Vol. 7　No. 5　p. 743-747　1997/10　Research paper (scientific journal)

Changes in T, B, and NK lymphocyte subsets during and after normal pregnancy

Mikio Watanabe, Yoshinori Iwatani, Tatsunari Kaneda, Yoh Hidaka, Nobuaki Mitsuda, Yasuhiko Morimoto, Nobuyuki Amino

American Journal of Reproductive Immunology　Vol. 37　No. 5　p. 368-377　1997　Research paper (scientific journal)

Changes in soluble CD4 and CD8 proteins in healthy pregnant and postpartum women

M Watanabe, Y Iwatani, Y Hidaka, N Mitsuda, N Amino

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY　Vol. 36　No. 4　p. 220-227　1996/10　Research paper (scientific journal)

A Patient With Postpartum Central Hypoadrenalism

Mikio Watanabe, Takashi Iijima, Taku Kashiwai, Motoko Kimura, Yoshinori Iwatani, Nobuyuki Amino

1995/05　Research paper (scientific journal)

A Patient With Euthyroid Graves' Disease Showing No Thyroid Abnormalities Except Positive Thyroid Stimulating Antibody (TSAb)

Mikio Watanabe, Takashi Iijima, Taku Kashiwai, Haruo Tamaki, Takashi Fujikado, Yoshinori Iwatani, Nobuyuki Amino

1995/02　Research paper (scientific journal)

Euthyroid Graves' disease showing no thyroid abnormalities except positive thyroid‐stimulating antibody (TSAb): two case reports

MIKIO WATANABE, YOSHINORI IWATANL, TAKU KASHIWAI, TAKASHI IIJIMA, TAKASHI FUJIKADO, NOBUYUKI AMINO

Journal of Internal Medicine　Vol. 238　No. 4　p. 379-384　1995　Research paper (scientific journal)

Long-Term Effects of Thyroid Hormone on Lymphocyte Subsets in Spleens and Thymuses of Mice

Kiyoshi Watanabe, Yoh Hidaka, Mikio Watanabe, Nobuyuki Amino, Yoshinori Iwatani

Endocrine Journal　Vol. 42　No. 5　p. 661-668　1995　Research paper (scientific journal)