SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity

Masataka Kunii, Yuria Noguchi, Shin-ichiro Yoshimura, Satoshi Kanda, Tomohiko Iwano, Erda Avriyanti, Nur Atik, Takashi Sato, Ken Sato, Masaharu Ogawa, Akihiro Harada

Journal of Cell Biology　Vol. 220　No. 1　p. e201910080-e201910080　2021/01/04　Research paper (scientific journal)

Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation

Masato Kitano, Yasuhiko Kizuka, Tomoaki Sobajima, Miyako Nakano, Kazuki Nakajima, Ryo Misaki, Saki Itoyama, Yoichiro Harada, Akihiro Harada, Eiji Miyoshi, Naoyuki Taniguchi

Journal of Biological Chemistry　Vol. 296　No. 100354　p. 1-15　2021/01　Research paper (scientific journal)

Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation

Ayano Iwaki, Kenta Moriwaki, Tomoaki Sobajima, Manabu Taniguchi, Shin‐ichiro Yoshimura, Masataka Kunii, Satoshi Kanda, Yoshihiro Kamada, Eiji Miyoshi, Akihiro Harada

The FASEB Journal　Vol. 34　No. 7　p. 9450-9465　2020/07　Research paper (scientific journal)

Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice

Shinji Tanaka, Yasutaka Masuda, Akihiro Harada, Shigeo Okabe

Microscopy　Vol. 69　No. 1　p. 44-52　2020/03/09　Research paper (scientific journal)

Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER–mitochondria contact sites

Takeshi Harada, Ryota Sada, Yoshito Osugi, Shinji Matsumoto, Tomoki Matsuda, Mitsuko Hayashi-Nishino, Takeharu Nagai, Akihiro Harada, Akira Kikuchi

Journal of Cell Science　Vol. 133　No. jcs249045　p. 1-16　2020/01/01　Research paper (scientific journal)

Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder

Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo

Cell Reports　Vol. 29　No. 13　p. 4362-4376.e6　2019/12　Research paper (scientific journal)

The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1

Rossella Venditti, Maria Chiara Masone, Laura Rita Rega, Giuseppe Di Tullio, Michele Santoro, Elena Polishchuk, Ivan Castello Serrano, Vesa M. Olkkonen, Akihiro Harada, Diego L. Medina, Raffaele La Montagna, Maria Antonietta De Matteis

Journal of Cell Biology　Vol. 218　No. 3　p. 783-797　2019/03/04　Research paper (scientific journal)

C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization

Mariko Takahara, Masataka Kunii, Kentaro Nakamura, Akihiro Harada, Tomoaki Hirano, Yohei Katoh, Kazuhisa Nakayama

The Journal of Biochemistry　Vol. 165　No. 3　p. 257-267　2019/03/01　Research paper (scientific journal)

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura

Nature Communications　Vol. 9　No. 1　p. 4604-4604　2018/12　Research paper (scientific journal)

VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice

Kyota Aoyagi, Makoto Itakura, Toshiyuki Fukutomi, Chiyono Nishiwaki, Yoko Nakamichi, Seiji Torii, Tomohiko Makiyama, Akihiro Harada, Mica Ohara-Imaizumi

Endocrinology　Vol. 159　No. 11　p. 3674-3688　2018/11/01　Research paper (scientific journal)

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Tomoya Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Genta Ito, Shin-ichiro Yoshimura, Akihiro Harada, Mitsunori Fukuda, Masato Koike, Takeshi Iwatsubo

Proceedings of the National Academy of Sciences　Vol. 115　No. 39　p. E9115-E9124　2018/09/25　Research paper (scientific journal)

The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution

Tomoaki Sobajima, Shin-ichiro Yoshimura, Tomomi Maeda, Haruhiko Miyata, Eiji Miyoshi, Akihiro Harada

Journal of Cell Biology　Vol. 217　No. 5　p. 1777-1796　2018/05/01　Research paper (scientific journal)

A Novel Contact by a Novel Protein Complex Supports Cholesterol Transport to the Endoplasmic Reticulum

Akihiro Harada

Contact　Vol. 1　p. 251525641877968-251525641877968　2018/01　Research paper (scientific journal)

UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage- specific manner

Tokiro Ishikawa, Takuya Toyama, Yuki Nakamura, Kentaro Tamada, Hitomi Shimizu, Satoshi Ninagawa, Tetsuya Okada, Yasuhiro Kamei, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Eriko Aoyama, Masaharu Takigawa, Akihiro Harada, Kazutoshi Mori

Journal of Cell Biology　Vol. 216　No. 6　p. 1761-1774　2017/06/01　Research paper (scientific journal)

BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain

Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shinichiro Yoshimura, Kenta Moriwaki, Akihiro Harada

PLoS ONE　Vol. 12　No. 4　p. e0175888-e0175888　2017/04/01　Research paper (scientific journal)

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis

Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar

Cell Reports　Vol. 18　No. 2　p. 508-519　2017/01/10　Research paper (scientific journal)

Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta

David A. Parry, Claire E.L. Smith, Walid El-Sayed, James A. Poulter, Roger C. Shore, Clare V. Logan, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Akihiro Harada, Hong Zhang, Mine Koruyucu, Figen Seymen, Jan C.-C. Hu, James P. Simmer, Mushtaq Ahmed, Hussain Jafri, Colin A. Johnson, Chris F. Inglehearn, Alan J. Mighell

American Journal of Human Genetics　Vol. 99　No. 4　p. 984-990　2016/10/06　Research paper (scientific journal)

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

Masataka Kunii, Mica Ohara-Imaizumi, Noriko Takahashi, Masaki Kobayashi, Ryosuke Kawakami, Yasumitsu Kondoh, Takeshi Shimizu, Siro Simizu, Bangzhong Lin, Kazuto Nunomura, Kyota Aoyagi, Mitsuyo Ohno, Masaki Ohmuraya, Takashi Sato, Shin-ichiro Yoshimura, Ken Sato, Reiko Harada, Yoon-Jeong Kim, Hiroyuki Osada, Tomomi Nemoto, Haruo Kasai, Tadahiro Kitamura, Shinya Nagamatsu, Akihiro Harada

JOURNAL OF CELL BIOLOGY　Vol. 215　No. 1　p. 121-138　2016/10　Research paper (scientific journal)

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic beta-Cells

Kyota Aoyagi, Mica Ohara-Imaizumi, Makoto Itakura, Seiji Torii, Yoshihiro Akimoto, Chiyono Nishiwaki, Yoko Nakamichi, Takuma Kishimoto, Hayato Kawakami, Akihiro Harada, Masami Takahashi, Shinya Nagamatsu

DIABETES　Vol. 65　No. 6　p. 1648-1659　2016/06　Research paper (scientific journal)

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons

Yukari Hayashi, Hiroshi Nishimune, Katsuto Hozumi, Yumiko Saga, Akihiro Harada, Michisuke Yuzaki, Takeshi Iwatsubo, Raphael Kopan, Taisuke Tomita

Scientific Reports　Vol. 6　2016/04/04　Research paper (scientific journal)

Rab8b regulates transport of West Nile virus particles from recycling endosomes

Shintaro Kobayashi, Tadaki Suzuki, Akira Kawaguchi, Wallaya Phongphaew, Kentaro Yoshii, Tomohiko Iwanofi, Akihiro Harada, Hiroaki Kariwa, Yasuko Orba, Hirofumi Sawa

Journal of Biological Chemistry　Vol. 291　No. 12　p. 6559-6568　2016/03/18　Research paper (scientific journal)

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.

Atsuhiro Nakajo, Shin-ichiro Yoshimura, Hiroko Togawa, Masataka Kunii, Tomohiko Iwano, Ayaka Izumi, Yuria Noguchi, Ayako Watanabe, Ayako Goto, Toshiro Sato, Akihiro Harada

The Journal of cell biology　Vol. 212　No. 3　p. 297-306　2016/02/01　Research paper (scientific journal)

VAMP7はオートファジーを制御してミトコンドリアの恒常性維持と第2相インスリン分泌を調節する

青柳 共太, 今泉 美佳, 板倉 誠, 鳥居 征司, 秋元 義弘, 西脇 知世乃, 中道 洋子, 岸本 拓磨, 原田 彰宏, 高橋 正身, 永松 信哉

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [4T特L-07(3P1198)]　2015/12　Research paper (other academic)

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.

Soumyashree Das, Shiyan Yu, Ryotaro Sakamori, Pavan Vedula, Qiang Feng, Juan Flores, Andrew Hoffman, Jiang Fu, Ewa Stypulkowski, Alexis Rodriguez, Radek Dobrowolski, Akihiro Harada, Wei Hsu, Edward M Bonder, Michael P Verzi, Nan Gao

Development (Cambridge, England)　Vol. 142　No. 12　p. 2147-62　2015/06/15　Research paper (scientific journal)

メンブレントラフィック 分子から個体まで VAMP7はオートファジーによるミトコンドリア恒常性維持機構を介して膵β細胞からの第2相インスリン分泌を制御する

青柳 共太, 今泉 美佳, 板倉 誠, 鳥居 征司, 岸本 拓磨, 西脇 知世乃, 中道 洋子, 秋元 義弘, 原田 彰宏, 高橋 正身, 永松 信哉

日本細胞生物学会大会講演要旨集　Vol. 67回　p. 123-123　2015/06　Research paper (other academic)

Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity

Erda Avriyanti, Nur Atik, Masataka Kunii, Naomi Furumoto, Tomohiko Iwano, Shin-ichiro Yoshimura, Reiko Harada, Akihiro Harada

Neuroscience Research　Vol. 95　p. 12-20　2015/06/01　Research paper (scientific journal)

VAMP7による第2相インスリン分泌の制御機構

青柳 共太, 今泉 美佳, 板倉 誠, 鳥居 征司, 西脇 知世乃, 中道 洋子, 岸本 拓磨, 原田 彰宏, 秋元 義弘, 高橋 正身, 永松 信哉

糖尿病　Vol. 58　No. Suppl.1　p. S-147　2015/04　Research paper (other academic)

Rab11a is required for apical protein localisation in the intestine

Tomoaki Sobajima, Shin-Ichiro Yoshimura, Tomohiko Iwano, Masataka Kunii, Masahiko Watanabe, Nur Atik, Sotaro Mushiake, Eiichi Morii, Yoshihisa Koyama, Eiji Miyoshi, Akihiro Harada

Biology Open　Vol. 4　No. 1　p. 86-94　2015/01/15　Research paper (scientific journal)

Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells.

Keiko Saegusa, Miyuki Sato, Katsuya Sato, Junko Nakajima-Shimada, Akihiro Harada, Ken Sato

Molecular biology of the cell　Vol. 25　No. 20　p. 3095-104　2014/10/15　Research paper (scientific journal)

Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2

Masahiro Akiyama, Hiroshi Hasegawa, Tsunaki Hongu, Michael A. Frohman, Akihiro Harada, Hiroyuki Sakagami, Yasunori Kanaho

Nature Communications　Vol. 5　No. 1　2014/08/21　Research paper (scientific journal)

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

Tsutomu Sasaki, Osamu Kikuchi, Mayumi Shimpuku, Vina Yanti Susanti, Hiromi Yokota-Hashimoto, Ryo Taguchi, Nobuyuki Shibusawa, Takashi Sato, Lijun Tang, Kosuke Amano, Tomoya Kitazumi, Mitsutaka Kuroko, Yuki Fujita, Jun Maruyama, Yong-soo Lee, Masaki Kobayashi, Takashi Nakagawa, Yasuhiko Minokoshi, Akihiro Harada, Masanobu Yamada, Tadahiro Kitamura

DIABETOLOGIA　Vol. 57　No. 4　p. 819-831　2014/04　Research paper (scientific journal)

The role of PKD in cell polarity, biosynthetic pathways, and organelle/f-actin distribution

Nur Atik, Masataka Kunii, Erda Avriyanti, Naomi Furumoto, Keiko Inami, Shin-Ichiro Yoshimura, Reiko Harada, Akihiro Harada

Cell Structure and Function　Vol. 39　No. 1　p. 61-77　2014/01/31　Research paper (scientific journal)

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis

Takashi Sato, Tomohiko Iwano, Masataka Kunii, Shinji Matsuda, Rumiko Mizuguchi, Yongwook Jung, Haruo Hagiwara, Yoshihiro Yoshihara, Michisuke Yuzaki, Reiko Harada, Akihiro Harada

Journal of Cell Science　Vol. 127　No. 2　p. 422-431　2014/01　Research paper (scientific journal)

CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development

Tomohiro Tanaka, Tomoko Wakabayashi, Hiroaki Oizumi, Shu Nishio, Takashi Sato, Akihiro Harada, Daisuke Fujii, Yuko Matsuo, Tadafumi Hashimoto, Takeshi Iwatsubo

Journal of Neuroscience　Vol. 34　No. 4　p. 1370-1379　2014　Research paper (scientific journal)

Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function

Barbara Vacca, Elsa Bazellières, Roqiya Nouar, Akihiro Harada, Dominique Massey-Harroche, André Le Bivic

Human Molecular Genetics　Vol. 23　No. 11　p. 2834-2846　2014　Research paper (scientific journal)

Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model

Haruka Aoki, Chihiro Mogi, Takeshi Hisada, Takashi Nakakura, Yosuke Kamide, Isao Ichimonji, Hideaki Tomura, Masayuki Tobo, Koichi Sato, Hiroaki Tsurumaki, Kunio Dobashi, Tetsuya Mori, Akihiro Harada, Masanobu Yamada, Masatomo Mori, Tamotsu Ishizuka, Fumikazu Okajima

PLoS ONE　Vol. 8　No. 11　2013/11/11　Research paper (scientific journal)

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

Giovanni D'Angelo, Takefumi Uemura, Chia-Chen Chuang, Elena Polishchuk, Michele Santoro, Henna Ohvo-Rekila, Takashi Sato, Giuseppe Di Tullio, Antonio Varriale, Sabato D'Auria, Tiziana Daniele, Fabrizio Capuani, Ludger Johannes, Peter Mattjus, Maria Monti, Piero Pucci, Roger L. Williams, John E. Burke, Frances M. Platt, Akihiro Harada, Maria Antonietta De Matteis

NATURE　Vol. 501　No. 7465　2013/09　Research paper (scientific journal)

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 5　p. 1726-1731　2013/01/29　Research paper (scientific journal)

Uncovering genes required for neuronal morphology by morphology‐based gene trap screening with a revertible retrovirus vector

Yukiko Hashimoto, Kazuhiro Muramatsu, Masataka Kunii, Shin‐ichiro Yoshimura, Minami Yamada, Takashi Sato, Yasumasa Ishida, Reiko Harada, Akihiro Harada

The FASEB Journal　Vol. 26　No. 11　p. 4662-4674　2012/11　Research paper (scientific journal)

Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.

Takashi Nakakura, Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Koichi Sato, Masaki Kobayashi, Hiroshi Ohnishi, Shigeyasu Tanaka, Mitsutoshi Wayama, Tetsuya Sugiyama, Tadahiro Kitamura, Akihiro Harada, Fumikazu Okajima

Endocrinology　Vol. 153　No. 9　p. 4171-80　2012/09　Research paper (scientific journal)

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

Ryotaro Sakamori, Soumyashree Das, Shiyan Yu, Shanshan Feng, Ewa Stypulkowski, Yinzheng Guan, Veronique Douard, Waixing Tang, Ronaldo P. Ferraris, Akihiro Harada, Cord Brakebusch, Wei Guo, Nan Gao

Journal of Clinical Investigation　Vol. 122　No. 3　p. 1052-1065　2012/03/01　Research paper (scientific journal)

Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos

Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki, Yoh Wada

Nature Communications　Vol. 3　No. 1　2012　Research paper (scientific journal)

The Role of VAMP7/TI-VAMP in Cell Polarity and Lysosomal Exocytosis in vivo

Mahito Sato, Shinichiro Yoshimura, Rika Hirai, Ayako Goto, Masataka Kunii, Nur Atik, Takashi Sato, Ken Sato, Reiko Harada, Junko Shimada, Toshimitsu Hatabu, Hiroshi Yorifuji, Akihiro Harada

Traffic　Vol. 12　No. 10　p. 1383-1393　2011/10　Research paper (scientific journal)

Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells

Miyuki Sato, Keiko Saegusa, Katsuya Sato, Taichi Hara, Akihiro Harada, Ken Sato

Molecular Biology of the Cell　Vol. 22　No. 14　p. 2579-2587　2011/07/15　Research paper (scientific journal)

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

Keisuke Yamamoto, Kazuna Takahara, Seiichi Oyadomari, Tetsuya Okada, Takashi Sato, Akihiro Harada, Kazutoshi Mori

Molecular Biology of the Cell　Vol. 21　No. 17　p. 2975-2986　2010/09　Research paper (scientific journal)

Molecular mechanism of polarized transport

A. Harada

Journal of Biochemistry　Vol. 147　No. 5　p. 619-624　2010/05/01　Research paper (scientific journal)

A Novel Role for hGas7b in Microtubular Maintenance

Hirotada Akiyama, Aina Gotoh, Ryong-Woon Shin, Tomoe Koga, Tsubasa Ohashi, Wataru Sakamoto, Akihiro Harada, Hiroyuki Arai, Akira Sawa, Chiyoko Uchida, Takafumi Uchida

Journal of Biological Chemistry　Vol. 284　No. 47　p. 32695-32699　2009/11/20　Research paper (scientific journal)

低分子量GTPaseから眺めるメンブレントラフィック研究の新展開 低分子量GTPase Rab8の生体における機能について

原田 彰宏, 佐藤 隆史

日本生化学会大会プログラム・講演要旨集　Vol. 82回　p. 3S1a-3　2009/09　Research paper (conference, symposium, etc.)

Generation of Cortactin Floxed Mice and Cellular Analysis of Motility in Fibroblasts

Shinji Tanaka, Masataka Kunii, Akihiro Harada, Shigeo Okabe

GENESIS　Vol. 47　No. 9　p. 638-646　2009/09　Research paper (scientific journal)

Rab8b GTPaseヌル変異マウスの作製と解析(Generation and analysis of Rab8b GTPase null-mutant mice)

佐藤 隆史, 國井 政孝, 原田 玲子, 原田 彰宏

日本細胞生物学会大会講演要旨集　Vol. 61回　p. 164-164　2009/05　Research paper (conference, symposium, etc.)

p31 Deficiency Influences Endoplasmic Reticulum Tubular Morphology and Cell Survival

Takefumi Uemura, Takashi Sato, Takehiro Aoki, Akitsugu Yamamoto, Tetsuya Okada, Rika Hirai, Reiko Harada, Kazutoshi Mori, Mitsuo Tagaya, Akihiro Harada

Molecular and Cellular Biology　Vol. 29　No. 7　p. 1869-1881　2009/04/01　Research paper (scientific journal)

細胞極性関連因子VAMP7欠失マウスの解析

佐藤 真人, 佐藤 隆史, 植村 武文, 國井 政孝, 多鹿 友喜, 村上 徹, 依藤 宏, 原田 彰宏

解剖学雑誌　Vol. 84　No. Suppl.　p. 194-194　2009/03　Research paper (other academic)

種々の細胞内現象と細胞内小器官に対する形態および機能面からのアプローチ 極性輸送関連分子欠損マウスを用いた細胞極性形成、維持のメカニズムの解明

原田 彰宏, 佐藤 隆史

解剖学雑誌　Vol. 84　No. Suppl.　p. 104-104　2009/03　Research paper (other academic)

細胞極性の維持におけるRab8aおよびRab8bの役割

佐藤 隆史, 佐藤 健, 佐藤 美由紀, 平井 里香, 原田 玲子, 原田 彰宏

解剖学雑誌　Vol. 84　No. Suppl.　p. 194-194　2009/03　Research paper (other academic)

SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis

Hisanobu Sadakata, Hideki Okazawa, Takashi Sato, Yana Supriatna, Hiroshi Ohnishi, Shinya Kusakari, Yoji Murata, Tomokazu Ito, Uichi Nishiyama, Takashi Minegishi, Akihiro Harada, Takashi Matozaki

GENES TO CELLS　Vol. 14　No. 3　p. 295-308　2009/03　Research paper (scientific journal)

Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages

Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Naoya Murata, Xiao-Dong He, Koichi Sato, Takao Kimura, Tamotsu Ishizuka, Takehiko Sasaki, Takashi Sato, Yasuyuki Kihara, Satoshi Ishii, Akihiro Harada, Fumikazu Okajima

JOURNAL OF IMMUNOLOGY　Vol. 182　No. 5　p. 3243-3251　2009/03　Research paper (scientific journal)

Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice

Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada, Akira Tsuji

DRUG METABOLISM AND DISPOSITION　Vol. 37　No. 3　p. 602-607　2009/03　Research paper (scientific journal)

血小板分化におけるプロリン異性化酵素Pin1の機能解析

鈴木 伸幸, 小野 栄夫, 北沢 博, 本橋 ほづみ, 原田 彰宏, 秋山 弘匡, 内田 隆史

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 81回・31回　p. 1T12-10　2008/11　Research paper (other academic)

Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans

Miyuki Sato, Barth D. Grant, Akihiro Harada, Ken Sato

JOURNAL OF CELL SCIENCE　Vol. 121　No. 19　p. 3177-3186　2008/10　Research paper (scientific journal)

Rab蛋白質の高次機能 小腸上皮細胞の細胞極性及び機能におけるRab8の役割(Functional roles of Rab proteins in mammalian differentiated tissues The Rab8 GTPase regulates apical protein localization in intestinal cells)

佐藤 隆史, 佐藤 美由紀, 原田 玲子, 佐藤 健, 原田 彰宏

日本細胞生物学会大会講演要旨集　Vol. 60回　p. 92-92　2008/06

Rab8は小腸上皮におけるアピカル蛋白の局在と微絨毛の維持に必須である(Rab8 regulates apical protein localization in intestinal cells and nutritional absorption)

佐藤 隆史, 佐藤 健, 佐藤 美由紀, 原田 玲子, 原田 彰宏

日本細胞生物学会大会講演要旨集　Vol. 60回　p. 139-139　2008/06

Neuron-specific recombination by Cre recombinase inserted into the murine tau locus

Kazuhiro Muramatsu, Yukiko Hashimoto, Takefumi Uemura, Masataka Kunii, Reiko Harada, Takashi Sato, Akihiro Morikawa, Akihiro Harada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 370　No. 3　p. 419-423　2008/06　Research paper (scientific journal)

神経細胞特異的ノックアウトマウスの作製と解析

村松 一洋, 緒方 朋実, 澤浦 法子, 原田 彰宏, 森川 昭廣

脳と発達　Vol. 40　No. Suppl.　p. S406-S406　2008/05

Neuron-specific and inducible recombination by Cre recombinase in the mouse

Yukiko Hashi Moto, Kazuhiro Muramatsu, Takefumi Uemura, Reiko Harada, Takashi Sato, Koichi Okamoto, Akihiro Harada

NEUROREPORT　Vol. 19　No. 6　p. 621-624　2008/04　Research paper (scientific journal)

Regulation of endocytic recycling by C-elegans Rab35 and its regulator RME-4, a coated-pit protein

Miyuki Sato, Ken Sato, Willisa Liou, Saumya Pant, Akihiro Harada, Barth D. Grant

EMBO JOURNAL　Vol. 27　No. 8　p. 1183-1196　2008/04　Research paper (scientific journal)

細胞極性関連因子VAMP7欠失マウスの作製と解析

佐藤 真人, 佐藤 隆史, 植村 武文, 國井 政孝, 多鹿 友喜, 村上 徹, 依藤 宏, 原田 彰宏

解剖学雑誌　Vol. 83　No. Suppl.　p. 193-193　2008/03

消化管の分子解剖学 消化吸収を観る 極性輸送制御因子Rab8は、離乳後の小腸吸収上皮細胞apical蛋白の局在と栄養吸収機能に必須である

佐藤 隆史, 佐藤 健, 佐藤 美由紀, 國井 政孝, 原田 玲子, 原田 彰宏

解剖学雑誌　Vol. 83　No. Suppl.　p. 108-108　2008/03

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

Yusuke Adachi, Keisuke Yamamoto, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 75-89　2008　Research paper (scientific journal)

脳特異的に発現するGas7はリン酸化Tauに結合し微小管シート構造を安定化させた

東 誉人, 辛 龍雲, 原田 彰宏, 秋山 弘匡, 内田 隆史

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 80回・30回　p. 4T21-4　2007/11

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6 alpha and XBP1

Keisuke Yamamoto, Takashi Sato, Toshie Matsui, Masanori Sato, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori

DEVELOPMENTAL CELL　Vol. 13　No. 3　p. 365-376　2007/09　Research paper (scientific journal)

The Rab8 GTPase regulates apical protein localization in intestinal cells

Takashi Sato, Sotaro Mushiake, Yukio Kato, Ken Sato, Miyuki Sato, Naoki Takeda, Keiichi Ozono, Kazunori Miki, Yoshiyuki Kubo, Akira Tsuji, Reiko Harada, Akihiro Harada

NATURE　Vol. 448　No. 7151　p. 366-369　2007/07　Research paper (scientific journal)

14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice

Katsunori Fujio, Mahito Sato, Takefumi Uemura, Takashi Sato, Reiko Sato-Harada, Akihiro Harada

NEUROREPORT　Vol. 18　No. 10　p. 1049-1052　2007/07　Research paper (scientific journal)

Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells

Xinghua Hou, Li Wei, Akihiro Harada, Kazuhiko Tatamoto

LUNG CANCER　Vol. 54　No. 2　p. 143-148　2006/11　Research paper (scientific journal)

Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation

Eisei Sohara, Tatemitsu Rai, Sung-Sen Yang, Keiko Uchida, Kosaku Nitta, Shigeru Horita, Mayuko Ohno, Akihiro Harada, Sei Sasaki, Shinichi Uchida

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 103　No. 38　p. 14217-14222　2006/09　Research paper (scientific journal)

Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient mice

N Iriuchijima, R Sato-Harada, M Takano, K Fujio, T Sato, F Goto, A Harada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 338　No. 2　p. 1216-1221　2005/12　Research paper (scientific journal)

TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor

JQ Wang, J Kon, C Mogi, M Tobo, A Damirin, K Sato, M Komachi, E Malchinkhuu, N Murata, T Kimura, A Kuwabara, K Wakamatsu, H Koizumi, T Uede, G Tsujimoto, H Kurose, T Sato, A Harada, N Misawa, H Tomura, F Okajima

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 44　p. 45626-45633　2004/10　Research paper (scientific journal)

Gem GTPase and Tau - Morphological changes induced by Gem GTPase in Cho cells are antagonized by tau

F Oyama, S Kotliarova, A Harada, M Ito, H Miyazaki, Y Ueyama, N Hirokawa, N Nukina, Y Ihara

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 26　p. 27272-27277　2004/06　Research paper (scientific journal)

Inhibitory neurons from fetal rat cerebral cortex exert delayed axon formation and active migration in vitro

K Hayashi, R Kawai-Hirai, A Harada, K Takata

JOURNAL OF CELL SCIENCE　Vol. 116　No. 21　p. 4419-4428　2003/11　Research paper (scientific journal)

MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction

A Harada, JL Teng, Y Takei, K Oguchi, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 158　No. 3　p. 541-549　2002/08　Research paper (scientific journal)

Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons

T Sato, R Sato-Harada, M Takano, S Kato, S Saburi, A Harada

NEUROSCIENCE LETTERS　Vol. 325　No. 2　p. 83-86　2002/06　Research paper (scientific journal)

微小管関連蛋白及び微小管依存性モーター蛋白遺伝子欠失マウスの作製とその分子細胞生物学的解析

原田 彰宏

北関東医学　Vol. 52　No. 2　p. 139-140　2002

Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization

J Teng, Y Takei, A Harada, T Nakata, N Hirokawa

MOLECULAR BIOLOGY OF THE CELL　Vol. 12　p. 433A-433A　2001/11　Research paper (scientific journal)

Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization

JL Teng, Y Takei, A Harada, T Nakata, JG Chen, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 155　No. 1　p. 65-76　2001/10　Research paper (scientific journal)

KIF5C, a novel neuronal kinesin enriched in motor neurons

Y Kanai, Y Okada, Y Tanaka, A Harada, S Terada, N Hirokawa

JOURNAL OF NEUROSCIENCE　Vol. 20　No. 17　p. 6374-6384　2000/09　Research paper (scientific journal)

Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes

Y Takei, JL Teng, A Harada, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 150　No. 5　p. 989-1000　2000/09　Research paper (scientific journal)

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice

S Ikegami, A Harada, N Hirokawa

NEUROSCIENCE LETTERS　Vol. 279　No. 3　p. 129-132　2000/02　Research paper (scientific journal)

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein (vol 95, pg 829, 95)

S Nonaka, Y Tanaka, Y Okada, S Takeda, A Harada, Y Kanai, M Kido, N Hirokawa

CELL　Vol. 99　No. 1　1999/10

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein

S Nonaka, Y Tanaka, Y Okada, S Takeda, A Harada, Y Kanai, M Kido, N Hirokawa

CELL　Vol. 95　No. 6　p. 829-837　1998/12　Research paper (scientific journal)

Targeted disruption of a mouse conventional kinesin heavy chain, kif5B, results in perinuclear clustering of mitochondria

Y Tanaka, Y Kanai, Y Okada, S Nonaka, S Takeda, A Harada, N Hirokawa

MOLECULAR BIOLOGY OF THE CELL　Vol. 9　p. 30A-30A　1998/11

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

Y Tanaka, Y Kanai, Y Okada, S Nonaka, S Takeda, A Harada, N Hirokawa

CELL　Vol. 93　No. 7　p. 1147-1158　1998/06　Research paper (scientific journal)

Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein

A Harada, Y Takei, Y Kanai, Y Tanaka, S Nonaka, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 141　No. 1　p. 51-59　1998/04　Research paper (scientific journal)

Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice

Y Yonekawa, A Harada, Y Okada, T Funakoshi, Y Kanai, Y Takei, S Terada, T Noda, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 141　No. 2　p. 431-441　1998/04　Research paper (scientific journal)

Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene

Y Takei, S Kondo, A Harada, S Inomata, T Noda, N Hirokawa

JOURNAL OF CELL BIOLOGY　Vol. 137　No. 7　p. 1615-1626　1997/06　Research paper (scientific journal)

Production and Analysis of Mice Deficient in Microtubule-Associated-Protein Tau.

HARADA Akihiro, OGUCHI Keiko, Okabe Shigeo, KUNO Junko, IKEGAMI Shiro, TERADA Sumio, OHSHIMA Takeshi, SATO-YOSHITAKE Reiko, NODA Tetsuo, HIROKAWA Nobutaka

Proceedings of The Japanese Society of Animal Models for Human Diseases　Vol. 11　p. 32-40　1995

ALTERED MICROTUBULE ORGANIZATION IN SMALL-CALIBER AXONS OF MICE LACKING TAU-PROTEIN

A HARADA, K OGUCHI, S OKABE, J KUNO, S TERADA, T OHSHIMA, R SATOYOSHITAKE, Y TAKEI, T NODA, N HIROKAWA

NATURE　Vol. 369　No. 6480　p. 488-491　1994/06　Research paper (scientific journal)

DEVELOPMENTAL-CHANGES OF SYNAPSIN-I SUBCELLULAR-LOCALIZATION IN RAT CEREBELLAR NEURONS

A HARADA, K SOBUE, N HIROKAWA

CELL STRUCTURE AND FUNCTION　Vol. 15　No. 6　p. 329-342　1990/12　Research paper (scientific journal)

THE CYTOSKELETAL ARCHITECTURE OF THE PRESYNAPTIC TERMINAL AND MOLECULAR-STRUCTURE OF SYNAPSIN .1.

N HIROKAWA, K SOBUE, K KANADA, A HARADA, H YORIFUJI

JOURNAL OF CELL BIOLOGY　Vol. 108　No. 1　p. 111-126　1989/01　Research paper (scientific journal)