Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kaneko

Nat Commun.　Vol. in press　No. 1　p. 7708-7708　2022/12　Research paper (scientific journal)

Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest.

HaiXiang Ma, Qian Yu, Yue Shen, XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu, HaiTing Zhao, Chang Zeng, Kazuki Nagayasu, HongHai Zhang

iScience　Vol. 25　No. 10　p. 105228-105228　2022/10/21　Research paper (scientific journal)

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.

Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto

Science advances　Vol. 8　No. 11　2022/03/18　Research paper (scientific journal)

Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.

Kaito Takayama, Shota Tobori, Chihiro Andoh, Masashi Kakae, Masako Hagiwara, Kazuki Nagayasu, Hisashi Shirakawa, Yukio Ago, Shuji Kaneko

Biological & pharmaceutical bulletin　Vol. 45　No. 8　p. 1124-1132　2022　Research paper (scientific journal)

Prediction of pharmacological activities from chemical structures with graph convolutional neural networks.

Miyuki Sakai, Kazuki Nagayasu, Norihiro Shibui, Chihiro Andoh, Kaito Takayama, Hisashi Shirakawa, Shuji Kaneko

Scientific reports　Vol. 11　No. 1　p. 525-525　2021/01/12　Research paper (scientific journal)

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.

Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Chihiro Andoh, Yuma Nagai, Haruko Kinoshita, Hiroyuki Kawai, Norihiro Shibui, Beihui Liu, James Hewinson, Hisashi Shirakawa, Takayuki Nakagawa, Hitoshi Hashimoto, Sergey Kasparov, Shuji Kaneko

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology　Vol. 44　No. 4　p. 721-732　2019/03　Research paper (scientific journal)

TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.

Chihiro Andoh, Naoya Nishitani, Emina Hashimoto, Yuma Nagai, Keizo Takao, Tsuyoshi Miyakawa, Takayuki Nakagawa, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Brain research　Vol. 1704　p. 68-77　2019/02/01　Research paper (scientific journal)

Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABA(B) receptor-mediated inhibition of L-type calcium channels

Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Hiroyuki Kawai, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/10　Research paper (scientific journal)

Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus

Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

NEUROPHARMACOLOGY　Vol. 95　p. 261-268　2015/08　Research paper (scientific journal)

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex

Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　Vol. 17　No. 8　p. 1321-1326　2014/08　Research paper (scientific journal)

Control of Intermale Aggression by Medial Prefrontal Cortex Activation in the Mouse

Aki Takahashi, Kazuki Nagayasu, Naoya Nishitani, Shuji Kaneko, Tsuyoshi Koide

PLOS ONE　Vol. 9　No. 4　2014/04　Research paper (scientific journal)

Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release

Kazuki Nagayasu, Maiko Kitaichi, Naoya Nishitani, Nozomi Asaoka, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　Vol. 16　No. 10　p. 2295-2306　2013/11　Research paper (scientific journal)

Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective 5-HT reuptake inhibitors on 5-HT release

Kazuki Nagayasu, Yumi Yatani, Maiko Kitaichi, Yutaka Kitagawa, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 161　No. 7　p. 1527-1541　2010/12　Research paper (scientific journal)

Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity.

Shota Tobori, Kosei Tamada, Nagi Uemura, Kyoko Sawada, Masashi Kakae, Kazuki Nagayasu, Takayuki Nakagawa, Yasuo Mori, Shuji Kaneko, Hisashi Shirakawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 122　No. 11　2025/03/18　Research paper (scientific journal)

Dorsal raphe nucleus to basolateral amygdala 5-HTergic neural circuit modulates restoration of consciousness during sevoflurane anesthesia.

Qian Yu, YuLing Wang, LeYuan Gu, WeiHui Shao, JiaXuan Gu, Lu Liu, XiTing Lian, Qing Xu, YuanLi Zhang, Yue Yang, ZhuoYue Zhang, YaXuan Wu, HaiXiang Ma, Yue Shen, Wen Ye, YanHui Wu, HuiFang Yang, LiHai Chen, Kazuki Nagayasu, HongHai Zhang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie　Vol. 176　p. 116937-116937　2024/07　Research paper (scientific journal)

Role of medial prefrontal cortex voltage-dependent potassium 4.3 channels in nicotine-induced enhancement of object recognition memory in male mice.

Hirohito Esaki, Shoma Izumi, Keisuke Nishikawa, Kazuki Nagayasu, Shuji Kaneko, Naoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda

European journal of pharmacology　Vol. 978　p. 176790-176790　2024/06/27　Research paper (scientific journal)

Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor.

Hikari Hatakama, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Translational psychiatry　Vol. 14　No. 1　p. 27-27　2024/01/16　Research paper (scientific journal)

[Multiplexed epigenetic analysis at single-cell resolution].

Kazuki Nagayasu

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 159　No. 4　p. 282-282　2024　Research paper (scientific journal)

[Unveiling RNA isoform diversity in the brain using long-read RNA sequencing].

Kazuki Nagayasu

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 159　No. 5　p. 342-342　2024　Research paper (scientific journal)

Integrative Research of Neuropharmacology and Informatics Pharmacology for Mental Disorder.

Kazuki Nagayasu

Biological & pharmaceutical bulletin　Vol. 47　No. 3　p. 556-561　2024　Research paper (scientific journal)

Correction: The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia.

HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhang

Molecular neurobiology　Vol. 60　No. 12　p. 6949-6949　2023/12

The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia.

HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhang

Molecular neurobiology　Vol. 60　No. 12　p. 6931-6948　2023/12　Research paper (scientific journal)

Early Detection of Adverse Drug Reaction Signals by Association Rule Mining Using Large-Scale Administrative Claims Data.

Hiroki Yamamoto, Gen Kayanuma, Takuya Nagashima, Chihiro Toda, Kazuki Nagayasu, Shuji Kaneko

Drug safety　Vol. 46　No. 4　p. 371-389　2023/02/24　Research paper (scientific journal)

Peripheral Beta-2 Adrenergic Receptors Mediate the Sympathetic Efferent Activation from Central Nervous System to Splenocytes in a Mouse Model of Fibromyalgia.

Shiori Yamashita, Naoki Dozono, Shota Tobori, Kazuki Nagayasu, Shuji Kaneko, Hisashi Shirakawa, Hiroshi Ueda

International journal of molecular sciences　Vol. 24　No. 4　2023/02/09　Research paper (scientific journal)

Inhibitors of the Mechanistic Target of Rapamycin Can Ameliorate Bortezomib-Induced Peripheral Neuropathy.

Mari Suzuki, Zijian Zhou, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

Biological & pharmaceutical bulletin　Vol. 46　No. 8　p. 1049-1056　2023　Research paper (scientific journal)

Vitamin D supplementation is effective for olanzapine-induced dyslipidemia.

Zijian Zhou, Takuya Nagashima, Chihiro Toda, Mone Kobayashi, Takahide Suzuki, Kazuki Nagayasu, Hisashi Shirakawa, Satoshi Asai, Shuji Kaneko

Frontiers in pharmacology　Vol. 14　p. 1135516-1135516　2023　Research paper (scientific journal)

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress.

Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Frontiers in pharmacology　Vol. 14　p. 1137952-1137952　2023　Research paper (scientific journal)

Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists.

Koki Nagaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Journal of pharmacological sciences　Vol. 151　No. 1　p. 9-16　2023/01　Research paper (scientific journal)

Specific Cellular Effects of Low Bortezomib Concentrations on Purified Cultures of Schwann Cells, Satellite Glial Cells, Macrophages, and Dorsal Root Ganglion Neurons.

Zijian Zhou, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Biological & pharmaceutical bulletin　Vol. 46　No. 1　p. 102-110　2023　Research paper (scientific journal)

Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes.

Hiroki Nakajima, Sayaka Fujita, Masashi Kakae, Kazuki Nagayasu, Masatsugu Oh-Hora, Hisashi Shirakawa, Shuji Kaneko

Glia　Vol. 70　No. 9　p. 1666-1680　2022/09　Research paper (scientific journal)

Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 34-34　2022/04/11

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 26-26　2022/03/28　Research paper (scientific journal)

Serotonin transporter: Recent progress of in silico ligand prediction methods and structural biology towards structure-guided in silico design of therapeutic agents.

Kazuki Nagayasu

Journal of pharmacological sciences　Vol. 148　No. 3　p. 295-299　2022/03　Research paper (scientific journal)

A selective serotonin reuptake inhibitor ameliorates obsessive–compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex

Hikari Hatakama, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Neuropharmacology　Vol. 206　p. 108926-108926　2022/03　Research paper (scientific journal)

Increased neuronal activity of serotonin neurons in the median raphe nucleus attenuates reward-related consummatory responses and facial expression

Yu Ohmura, Youcef Bouchekioua, Hiroyuki Kawai, Kazuki Nagayasu, Shuji Kaneko

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 96　p. 2-B　2022　Research paper (scientific journal)

Diff-ATAC-STARR-Seq: A Method for Genome-Wide Functional Screening of Enhancer Activity in Vivo.

Kazuki Nagayasu, Chihiro Andoh, Hisashi Shirakawa, Shuji Kaneko

Biological & pharmaceutical bulletin　Vol. 45　No. 10　p. 1590-1595　2022　Research paper (scientific journal)

Lisinopril prevents bullous pemphigoid induced by dipeptidyl peptidase 4 inhibitors via the Mas receptor pathway.

Keisuke Nozawa, Takahide Suzuki, Gen Kayanuma, Hiroki Yamamoto, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Frontiers in immunology　Vol. 13　p. 1084960-1084960　2022　Research paper (scientific journal)

Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling.

Koki Nagaoka, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Frontiers in neuroscience　Vol. 16　p. 1082375-1082375　2022　Research paper (scientific journal)

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.

Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, Masayuki Baba, Kohei Kitagawa, Tomoya Takemoto, Nanaka Gotoda-Nishimura, Tomohiro Takada, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Satoshi Kida, Kazuhiro Takuma, Fumihito Ono, Naomichi Matsumoto, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Translational psychiatry　Vol. 11　No. 1　p. 548-548　2021/10/25　Research paper (scientific journal)

Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain

Keigo Tanaka, Naoki Dozono, Hiroyuki Neyama, Jun Nagai, Ryoko Tsukahara, Kazuki Nagayasu, Shuji Kaneko, Hiroshi Ueda

Biochemical and Biophysical Research Communications　Vol. 568　p. 167-173　2021/09　Research paper (scientific journal)

MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.

Shota Tobori, Haruka Hiyama, Takahito Miyake, Yuichi Yano, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Yasuo Mori, Shuji Kaneko

Journal of pharmacological sciences　Vol. 146　No. 4　p. 200-205　2021/08　Research paper (scientific journal)

社会的敗北ストレスによるセロトニンニューロンの変化とその役割について

永安一樹, 金子周司

Clinical Neuroscience　Vol. 39　No. 6　p. 727-730　2021/06　Research paper (scientific journal)

Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia.

Koki Nagaoka, Takuya Nagashima, Nozomi Asaoka, Hiroki Yamamoto, Chihiro Toda, Gen Kayanuma, Soni Siswanto, Yasuhiro Funahashi, Keisuke Kuroda, Kozo Kaibuchi, Yasuo Mori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

JCI insight　Vol. 6　No. 10　2021/05/24　Research paper (scientific journal)

Pronociceptive Roles of Schwann Cell-Derived Galectin-3 in Taxane-Induced Peripheral Neuropathy.

Madoka Koyanagi, Satoshi Imai, Mayuna Matsumoto, Yoko Iguma, Nobuko Kawaguchi-Sakita, Takeshi Kotake, Yuki Iwamitsu, Mpumelelo Ntogwa, Ren Hiraiwa, Kazuki Nagayasu, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara

Cancer research　Vol. 81　No. 8　p. 2207-2219　2021/04/15　Research paper (scientific journal)

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder.

Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 14　No. 1　p. 56-56　2021/03/16　Research paper (scientific journal)

An essential role of the median raphe serotonin neurons projecting to the interpeduncular nucleus in reward processing.

Hiroyuki Kawai, Nagai Yuma, Koda Masashi, Nishitani Naoya, Nagayasu Kazuki, Shirakawa Hisashi, Kaneko Shuji

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease.

Soni Siswanto, Hiroki Yamamoto, Haruka Furuta, Mone Kobayashi, Takuya Nagashima, Gen Kayanuma, Kazuki Nagayasu, Yumiko Imai, Shuji Kaneko

Frontiers in pharmacology　Vol. 12　p. 635293-635293　2021　Research paper (scientific journal)

Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions.

Kana Ohashi, Koji Shibasaki, Hayaki Nakazawa, Ryotaro Kunimasa, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Biological & pharmaceutical bulletin　Vol. 44　No. 2　p. 181-187　2021　Research paper (scientific journal)

Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice.

Yasunori Asao, Shota Tobori, Masashi Kakae, Kazuki Nagayasu, Koji Shibasaki, Hisashi Shirakawa, Shuji Kaneko

Biochemical and biophysical research communications　Vol. 529　No. 3　p. 590-595　2020/08/27　Research paper (scientific journal)

Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.

Shintaro Wada, Junko Yanagida, Hitoki Sasase, Tong Zhang, Xueting Li, Hironori Kamii, Masaki Domoto, Satoshi Deyama, Eiichi Hinoi, Akihiro Yamanaka, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda

Neuropharmacology　Vol. 166　p. 107968-107968　2020/04　Research paper (scientific journal)

The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion.

Yuma Nagai, Kaito Takayama, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hisashi Shirakawa, Takayuki Nakagawa, Kazuki Nagayasu, Akihiro Yamanaka, Shuji Kaneko

International journal of molecular sciences　Vol. 21　No. 6　2020/03/21　Research paper (scientific journal)

光遺伝学的計測と操作を用いた報酬関連行動における正中縫線核セロトニン神経の役割の解明

河合 洋幸, 永井 佑茉, 好田 匡志, 永安 一樹, 白川 久志, 金子 周司

日本薬学会年会要旨集　Vol. 140年会　p. 26Q-am101S　2020/03

慢性脳低灌流による認知機能低下への反応性アストロサイトの関与

抱 将史, 森嶋 美沙, 戸堀 翔太, 永安 一樹, 白川 久志, 金子 周司

日本薬学会年会要旨集　Vol. 140年会　p. 27Q-am020S　2020/03

急性社会的敗北ストレス負荷によるコカイン欲求行動増強におけるノルアドレナリンおよびドパミン伝達の役割

李 雪てい, 柳田 淳子, 初 金玲, 本野 芽衣, 出山 諭司, 山中 章弘, 西谷 直也, 永安 一樹, 金子 周司, 金田 勝幸

日本薬学会年会要旨集　Vol. 140年会　p. 27Q-am025S　2020/03

急性社会的敗北ストレス負荷によるコカイン欲求行動増強におけるノルアドレナリンおよびドパミン伝達の役割

李 雪てい, 柳田 淳子, 初 金玲, 本野 芽衣, 出山 諭司, 山中 章弘, 西谷 直也, 永安 一樹, 金子 周司, 金田 勝幸

日本薬学会年会要旨集　Vol. 140年会　p. 27Q-am025S　2020/03

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.

Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki Baba, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Nature communications　Vol. 11　No. 1　p. 859-859　2020/02/26　Research paper (scientific journal)

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.

Tong Zhang, Junko Yanagida, Hironori Kamii, Shintaro Wada, Masaki Domoto, Hitoki Sasase, Satoshi Deyama, Takeshi Takarada, Eiichi Hinoi, Kenji Sakimura, Akihiro Yamanaka, Takashi Maejima, Michihiro Mieda, Takeshi Sakurai, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda

Addiction biology　Vol. 25　No. 1　2020/01　Research paper (scientific journal)

Myelin Oligodendrocyte Glycoprotein 35-55 (MOG 35-55)-induced Experimental Autoimmune Encephalomyelitis: A Model of Chronic Multiple Sclerosis.

Sakie Miyamura, Nagisa Matsuo, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Bio-protocol　Vol. 9　No. 24　2019/12/20　Research paper (scientific journal)

Autism-associated protein kinase D2 regulates embryonic cortical neuron development.

Kensuke Matsumura, Masayuki Baba, Kazuki Nagayasu, Kana Yamamoto, Momoka Kondo, Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Toshihiko Kuriu, Tokuichi Iguchi, Makoto Sato, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Biochemical and biophysical research communications　Vol. 519　No. 3　p. 626-632　2019/11/12　Research paper (scientific journal)

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.

Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Yuichiro Naka, Kensuke Matsumura, Momoka Kondo, Kana Yamamoto, Misuzu Hayashida, Atsushi Kasai, Yukio Ago, Kazuki Nagayasu, Atsuko Hayata-Takano, Akinori Takahashi, Shun Yamaguchi, Daisuke Mori, Norio Ozaki, Tadashi Yamamoto, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology　Vol. 44　No. 12　p. 2125-2135　2019/11　Research paper (scientific journal)

Identification of neuron-type specific promoters in monkey genome and their functional validation in mice.

Yuma Nagai, Naoya Nishitani, Masaharu Yasuda, Yasumasa Ueda, Yuto Fukui, Chihiro Andoh, Hisashi Shirakawa, Takayuki Nakagawa, Ken-Ichi Inoue, Kazuki Nagayasu, Sergey Kasparov, Kae Nakamura, Shuji Kaneko

Biochemical and biophysical research communications　Vol. 518　No. 4　p. 619-624　2019/10/22　Research paper (scientific journal)

CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice.

Naoya Nishitani, Yu Ohmura, Kazuki Nagayasu, Norihiro Shibui, Shuji Kaneko, Akiko Ohashi, Takayuki Yoshida, Akihiro Yamanaka, Mitsuhiro Yoshioka

Brain research　Vol. 1719　p. 243-252　2019/09/15　Research paper (scientific journal)

Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model.

Masashi Kakae, Shota Tobori, Misa Morishima, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

Biochemical and biophysical research communications　Vol. 514　No. 4　p. 1040-1044　2019/07/05　Research paper (scientific journal)

Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.

Masashi Kakae, Jun Miyanohara, Misa Morishima, Kazuki Nagayasu, Yasuo Mori, Hisashi Shirakawa, Shuji Kaneko

Neuroscience　Vol. 408　p. 204-213　2019/06/01　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.

Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimoto

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 39　No. 22　p. 4208-4220　2019/05/29　Research paper (scientific journal)

An Adenosine A_2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis.

Asaoka N, Nishitani N, Kinoshita H, Nagai Y, Hatakama H, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S

eNeuro　Vol. 6　No. 1　2019/01

[The biological basis and application of lentiviral vector and adeno-associated viral vector in pharmacological research].

Kazuki Nagayasu

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 153　No. 5　p. 204-209　2019　Research paper (scientific journal)

The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain.

Koichi Isami, Satoshi Imai, Asami Sukeishi, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

Brain, behavior, and immunity　Vol. 74　p. 121-132　2018/11　Research paper (scientific journal)

TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

Masato Tsutsui, Ryo Hirase, Sakie Miyamura, Kazuki Nagayasu, Takayuki Nakagawa, Yasuo Mori, Hisashi Shirakawa, Shuji Kaneko

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 38　No. 39　p. 8484-8495　2018/09/26　Research paper (scientific journal)

Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons.

Hiroyuki Kawai, Nozomi Asaoka, Takahito Miyake, Kazuki Nagayasu, Takayuki Nakagawa, Hisashi Shirakawa, Shuji Kaneko

Journal of pharmacological sciences　Vol. 137　No. 3　p. 313-316　2018/07　Research paper (scientific journal)

TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.

Kana Ohashi, Ayane Deyashiki, Takahito Miyake, Kazuki Nagayasu, Koji Shibasaki, Hisashi Shirakawa, Shuji Kaneko

Pflugers Archiv : European journal of physiology　Vol. 470　No. 5　p. 705-716　2018/05　Research paper (scientific journal)

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion.

Miyanohara J, Kakae M, Nagayasu K, Nakagawa T, Mori Y, Arai K, Shirakawa H, Kaneko S

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 38　No. 14　p. 3520-3533　2018/04　Research paper (scientific journal)

多角的視点から膜タンパク質機能とその創薬への応用を探究する 強迫性障害モデル動物の作成と治療ターゲット探索

浅岡 希美, 西谷 直也, 木ノ下 晴子, 永井 佑茉, 永安 一樹, 白川 久志, 中川 貴之, 金子 周司

日本薬学会年会要旨集　Vol. 138年会　No. 1　p. 328-328　2018/03

Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus.

Haruko Kinoshita, Naoya Nishitani, Yuma Nagai, Chihiro Andoh, Nozomi Asaoka, Hiroyuki Kawai, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

The international journal of neuropsychopharmacology　Vol. 21　No. 3　p. 305-310　2018/03/01　Research paper (scientific journal)

Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.

Tong Zhang, Satoshi Deyama, Masaki Domoto, Shintaro Wada, Junko Yanagida, Hitoki Sasase, Eiichi Hinoi, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Katsuyuki Kaneda

Biological & pharmaceutical bulletin　Vol. 41　No. 7　p. 1084-1088　2018　Research paper (scientific journal)

TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy.

Hiyama H, Yano Y, So K, Imai S, Nagayasu K, Shirakawa H, Nakagawa T, Kaneko S

Molecular pain　Vol. 14　2018/01

Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages

Asami Sukeishi, Koichi Isami, Haruka Hiyama, Satoshi Imai, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

MOLECULAR PAIN　Vol. 13　2017/11　Research paper (scientific journal)

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

Takahito Miyake, Saki Nakamura, Zhao Meng, Satoshi Hamano, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Kazuki Nagayasu, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko

FRONTIERS IN PHYSIOLOGY　Vol. 8　2017/11　Research paper (scientific journal)

Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide

Shohei Oyama, Koji Dogishi, Mizuki Kodera, Masashi Kakae, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

FRONTIERS IN PHYSIOLOGY　Vol. 8　2017/11　Research paper (scientific journal)

ラットにおいて光遺伝学的操作を可能とする神経種特異的ウイルスベクターを用いたセロトニン神経機能の解析

西谷 直也, 浅岡 希美, 木ノ下 晴子, 河合 洋幸, 澁井 紀宏, 永安 一樹, 白川 久志, 中川 貴之, 金子 周司

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 39回・47回　p. 158-158　2017/09

Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes

Hisashi Shirakawa, Rumi Katsumoto, Shota Iida, Takahito Miyake, Takuya Higuchi, Takuya Nagashima, Kazuki Nagayasu, Takayuki Nakagawa, Shuji Kaneko

GLIA　Vol. 65　No. 6　p. 1005-1016　2017/06　Research paper (scientific journal)

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

Kaoru Seiriki, Atsushi Kasai, Takeshi Hashimoto, Wiebke Schulze, Misaki Niu, Shun Yamaguchi, Takanobu Nakazawa, Ken-ichi Inoue, Shiori Uezono, Masahiko Takada, Yuichiro Naka, Hisato Igarashi, Masato Tanuma, James A. Waschek, Yukio Ago, Kenji F. Tanaka, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Hirooki Yabe, Takeharu Nagai, Katsumasa Fujita, Toshio Matsuda, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto

NEURON　Vol. 94　No. 6　p. 1085-+　2017/06　Research paper (scientific journal)

Elucidation of the Role of Dorsal Raphe Serotonergic Neurons in Mood Regulation Using Pharmacological and Viral Vector-based Approaches

Kazuki Nagayasu

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 137　No. 3　p. 341-346　2017/03

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells frommonozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine

Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimoto

SCHIZOPHRENIA RESEARCH　Vol. 181　p. 75-82　2017/03　Research paper (scientific journal)

セロトニン神経機能の光/化学遺伝学的解析の現状

永安一樹

精神科　Vol. 30　No. 1　p. 105-110　2017/01　Research paper (scientific journal)

Pharmacological approach for elucidating the role of dorsal raphe serotonin neurons in mood/emotion regulation.

Nagayasu K, Kaneko S

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 149　No. 1　p. 44-47　2017

A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons

Nozomi Asaoka, Hiroyuki Kawai, Naoya Nishitani, Haruko Kinoshita, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko

JOURNAL OF TOXICOLOGICAL SCIENCES　Vol. 41　No. 6　p. 813-816　2016/12　Research paper (scientific journal)

Prostaglandin D-2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction

Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Takuya Kanoh, Yukio Ago, Toshio Matsuda, Ryota Hashimoto, Kazutaka Ohi, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Atsuko Hayata-Takano, Kazuki Nagayasu, Kazuhiro Takuma, Asao Ogawa, Akemichi Baba, Hitoshi Hashimoto

BEHAVIOURAL BRAIN RESEARCH　Vol. 314　p. 77-86　2016/11　Research paper (scientific journal)

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder

Ryota Hashimoto, Takanobu Nakazawa, Yoshinori Tsurusaki, Yuka Yasuda, Kazuki Nagayasu, Kensuke Matsumura, Hitoshi Kawashima, Hidenaga Yamamori, Michiko Fujimoto, Kazutaka Ohi, Satomi Umeda-Yano, Masaki Fukunaga, Haruo Fujino, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Masatoshi Takeda, Naomichi Matsumoto, Hitoshi Hashimoto

JOURNAL OF HUMAN GENETICS　Vol. 61　No. 3　p. 199-206　2016/03　Research paper (scientific journal)

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.

Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H

Journal of molecular psychiatry　Vol. 4　2016

Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice

Kazuya Ikeda, Shuhei Tomimoto, Soken Tsuchiya, Ken-Ichi Hamagami, Norihito Shintani, Yukihiko Sugimoto, Atsushi Ichikawa, Atsushi Kasai, Takanobu Nakazawa, Kazuki Nagayasu, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

Biochemistry and Biophysics Reports　Vol. 2　p. 179-183　2015/07/01　Research paper (scientific journal)

ATOMOXETINE REVERSES LOCOMOTOR HYPERACTIVITY, IMPAIRED NOVEL OBJECT RECOGNITION, AND PREPULSE INHIBITION IMPAIRMENT IN MICE LACKING PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE

Y. Shibasaki, A. Hayata-Takano, K. Hazama, T. Nakazawa, N. Shintani, A. Kasai, K. Nagayasu, R. Hashimoto, M. Tanida, T. Katayama, S. Matsuzaki, K. Yamada, M. Taniike, Y. Onaka, Y. Ago, J. A. Waschek, K. Koeves, D. Regloedi, A. Tamas, T. Matsuda, A. Baba, H. Hashimoto

NEUROSCIENCE　Vol. 297　p. 95-104　2015/06　Research paper (scientific journal)

p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice

Shintaro Higashi, Kazuhiko Katagi, Norihito Shintani, Kazuya Ikeda, Yukihiko Sugimoto, Soken Tsuchiya, Naoki Inoue, Shota Tanaka, Mai Koumoto, Atsushi Kasai, Takanobu Nakazawa, Atsuko Hayata-Takano, Ken-Ichi Hamagami, Shuhei Tomimoto, Takuya Yoshida, Tadayasu Ohkubo, Kazuki Nagayasu, Yukio Ago, Yusuke Onaka, Ryota Hashimoto, Atsushi Ichikawa, Akemichi Baba, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 461　No. 4　p. 612-617　2015/06　Research paper (scientific journal)

CRTH2, a prostaglandin D-2 receptor, mediates depression-related behavior in mice

Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto

BEHAVIOURAL BRAIN RESEARCH　Vol. 284　p. 131-137　2015/05　Research paper (scientific journal)

Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus

Yuki Imoto, Toshihiko Kira, Mamiko Sukeno, Naoya Nishitani, Kazuki Nagayasu, Takayuki Nakagawa, Shuji Kaneko, Katsunori Kobayashi, Eri Segi-Nishida

MOLECULAR BRAIN　Vol. 8　2015/05　Research paper (scientific journal)

Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures

Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

NEUROSCIENCE LETTERS　Vol. 593　p. 72-77　2015/04　Research paper (scientific journal)

Utility of organotypic raphe slice cultures to investigate the effects of psychotropic drugs on the function of serotoninergic neurons

Takayuki Nakagawa, Kazuki Nagayasu, Shuji Kaneko

JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY　Vol. 35　No. 2　p. 39-44　2015/04

Simultaneous neuron- and astrocyte-specific fluorescent marking

Wiebke Schulze, Atsuko Hayata-Takano, Toshihiko Kamo, Takanobu Nakazawa, Kazuki Nagayasu, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Yukio Ago, Camille Farfan, Ryota Hashimoto, Akemichi Baba, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 459　No. 1　p. 81-86　2015/03　Research paper (scientific journal)

PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF

Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

Sergey Malchenko, Simone Treiger Sredni, Hitoshi Hashimoto, Atsushi Kasai, Kazuki Nagayasu, Jianping Xie, Naira V. Margaryan, Kaoru Seiriki, Rishi R. Lulla, Richard E. B. Seftor, Lauren M. Pachman, Herbert Y. Meltzer, Mary J. C. Hendrix, Marcelo B. Soares

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro

Atsushi Yamasaki, Atsushi Kasai, Akihiro Toi, Maki Kurita, Saki Kimoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Akira Ito, Herbert Y. Meltzer, Yukio Ago, James A. Waschek, Yusuke Onaka, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF NEUROCHEMISTRY　Vol. 132　No. 4　p. 418-428　2015/02　Research paper (scientific journal)

縫線核脳切片培養系の特徴と向精神薬によるセロトニン神経機能変化の作用解析

中川貴之, 永安一樹, 金子周司

日本神経精神薬理学雑誌　Vol. 35　p. 39-44　2015　Research paper (scientific journal)

ケタミンは縫線核AMPA受容体及びニコチン性アセチルコリン受容体を介して前頭前皮質5-HT遊離を引き起こす

西谷 直也, 永安 一樹, 浅岡 希美, 山城 茉弓, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 24回・44回　p. 200-200　2014/11

Behavioral characterization of mice overexpressing human dysbindin-1

Norihito Shintani, Yusuke Onaka, Ryota Hashimoto, Hironori Takamura, Tsuyoshi Nagata, Satomi Umeda-Yano, Akihiro Mouri, Takayoshi Mamiya, Ryota Haba, Shinsuke Matsuzaki, Taiichi Katayama, Hidenaga Yamamori, Takanobu Nakazawa, Kazuki Nagayasu, Yukio Ago, Yuki Yagasaki, Toshitaka Nabeshima, Masatoshi Takeda, Hitoshi Hashimoto

MOLECULAR BRAIN　Vol. 7　2014/10　Research paper (scientific journal)

Central CRTH2, a Second Prostaglandin D-2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

Ryota Haba, Norihito Shintani, Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF NEUROSCIENCE　Vol. 34　No. 7　p. 2514-2523　2014/02　Research paper (scientific journal)

Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice

Keisuke Hazama, Atsuko Hayata-Takano, Kazuki Uetsuki, Atsushi Kasai, Naoki Encho, Norihito Shintani, Kazuki Nagayasu, Ryota Hashimoto, Dora Reglodi, Tsuyoshi Miyakawa, Takanobu Nakazawa, Akemichi Baba, Hitoshi Hashimoto

PLOS ONE　Vol. 9　No. 2　2014/02　Research paper (scientific journal)

光遺伝学的手法を用いた背側縫線核セロトニン神経の特異的刺激による行動学的変化

西谷 直也, 永安 一樹, 浅岡 希美, 山城 茉弓, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 23回・43回　p. 184-184　2013/10

セロトニン神経における光遺伝学的解析を可能とするレンチウイルスベクターの開発

永安 一樹, 浅岡 希美, 西谷 直也, 山城 茉弓, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 23回・43回　p. 251-251　2013/10

Transient Receptor Potential Canonical 3 Inhibitor Pyr3 Improves Outcomes and Attenuates Astrogliosis After Intracerebral Hemorrhage in Mice

Masaya Munakata, Hisashi Shirakawa, Kazuki Nagayasu, Jun Miyanohara, Takahito Miyake, Takayuki Nakagawa, Hiroshi Katsuki, Shuji Kaneko

STROKE　Vol. 44　No. 7　p. 1981-+　2013/07　Research paper (scientific journal)

YOKUKANSAN INHIBITS MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE IN MICE: THE ROLE OF alpha(2A)-ADRENOCEPTOR

T. Nakagawa, K. Nagayasu, N. Nishitani, H. Shirakawa, K. Sekiguchi, Y. Ikarashi, Y. Kase, S. Kaneko

NEUROSCIENCE　Vol. 227　p. 336-349　2012/12　Research paper (scientific journal)

抗精神薬の縫線核培養切片への処置はセロトニンの遊離を引き起こす

永安 一樹, 北市 麻衣子, 浅岡 希美, 西谷 直也, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 22回・42回　p. 163-163　2012/10

抗うつ薬持続処置が縫線核培養切片での5-HT遊離に与える影響

北市 麻衣子, 永安 一樹, 白川 久志, 中川 貴之, 金子 周司

日本薬理学雑誌　Vol. 138　No. 4　p. 12P-12P　2011/10

縫線核培養切片を用いた抗うつ薬持続処置が5-HT遊離に与える影響の比較解析

北市 麻衣子, 永安 一樹, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 21回・41回　p. 156-156　2011/10

Repeated Exposure to Methamphetamine, Cocaine or Morphine Induces Augmentation of Dopamine Release in Rat Mesocorticolimbic Slice Co-Cultures

Takayuki Nakagawa, Yuichi Suzuki, Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Shuji Kaneko

PLOS ONE　Vol. 6　No. 9　2011/09　Research paper (scientific journal)

抗うつ薬持続処置によるセロトニン遊離増強におけるAMPA受容体の関与

更田 宏史, 永安 一樹, 北市 麻衣子, 白川 久志, 中川 貴之, 金子 周司

日本薬理学雑誌　Vol. 137　No. 3　p. 19P-19P　2011/03

抗うつ薬の縫線核培養切片への持続処置はAMPA受容体依存的な開口放出によるセロトニンの遊離を増強する

永安 一樹, 北市 麻衣子, 白川 久志, 中川 貴之, 金子 周司

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　Vol. 20回・40回　p. 134-134　2010/09

Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures

Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 113　No. 2　p. 197-201　2010/06　Research paper (scientific journal)

縫線核セロトニン神経含有中脳冠状切片におけるSSRI持続処置によるセロトニン遊離増強現象のメカニズム

中川 貴之, 永安 一樹, 八谷 有美, 北市 麻衣子, 白川 久志, 金子 周司

日本薬学会年会要旨集　Vol. 130年会　No. 3　p. 92-92　2010/03

Augmentation of serotonin release by sustained exposure to MDMA and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons

Megumi Higuchi, Yuichi Suzuki, Yumi Yatani, Yutaka Kitagawa, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko

JOURNAL OF NEUROCHEMISTRY　Vol. 106　No. 6　p. 2410-2420　2008/09　Research paper (scientific journal)