Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity

Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, Yuto Tokuda, Tomoka Nishimura, Koto Hidaka, Hiiro Mori, Makoto Oba, Takayoshi Suzuki

Chemical and Pharmaceutical Bulletin　Vol. 72　No. 7　p. 638-647　2024/07/01　Research paper (scientific journal)

Role of plant homeodomain finger protein 8 in P19 embryonic carcinoma cells revealed by genome editing and specific inhibitor

Shusuke Doi, Takayoshi Suzuki, Shuhei Soeda, Naoki Miyata, Tetsuya Inazu

Biochemistry and Biophysics Reports　Vol. 38　p. 101670-101670　2024/07　Research paper (scientific journal)

Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents

Yasunobu Yamashita, Yukihiro Itoh, Yuri Takada, Takayoshi Suzuki

Chemical and Pharmaceutical Bulletin　Vol. 72　No. 7　p. 630-637　2024/07/01　Research paper (scientific journal)

Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule.

Siyao Ni, Yuri Takada, Takaaki Ando, Shengwang Yu, Yasunobu Yamashita, Yukari Takahashi, Miho Sawada, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki

Bioorganic & medicinal chemistry letters　Vol. 105　p. 129759-129759　2024/06/01　Research paper (scientific journal)

General Synthesis of meso-1,4-Dialdehydes and Their Application in Ir-Catalyzed Asymmetric Tishchenko Reactions

Runze Zhao, Ismiyarto, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Hiroaki Sasai, Takeyuki Suzuki

ACS Omega　Vol. 9　No. 16　p. 17945-17955　2024/02/26　Research paper (scientific journal)

Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells.

Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki

Bioorganic & medicinal chemistry　Vol. 100　p. 117632-117632　2024/02/15　Research paper (scientific journal)

The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos

Ruiqi Shao, Takayoshi Suzuki, Mikita Suyama, Yuichi Tsukada

BMC Genomics　Vol. 25　No. 1　2024/02/05　Research paper (scientific journal)

Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity.

Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki

Bioorganic & medicinal chemistry　Vol. 98　p. 117579-117579　2024/01/15　Research paper (scientific journal)

A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1.

Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki

Chemical & pharmaceutical bulletin　Vol. 72　No. 2　p. 155-160　2024　Research paper (scientific journal)

Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning.

Atika Nurani, Yasunobu Yamashita, Yuuki Taki, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki

Chemical & pharmaceutical bulletin　Vol. 72　No. 2　p. 173-178　2024　Research paper (scientific journal)

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice

Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida

Neuron　2024/01　Research paper (scientific journal)

Discovery of HDAC8-selective inhibitors and their application to PROTACs

Yamashita Yasunobu, Takada Yuri, Itoh Yukihiro, Suzuki Takayoshi

MEDCHEM NEWS　Vol. 33　No. 4　p. 181-186　2023/11/01

Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation.

Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, Yasunobu Yamashita, Makoto Oba, Shusaku Uchida, Mitsuharu Masuda, Shinji Ito, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki

Journal of medicinal chemistry　2023/10/17　Research paper (scientific journal)

Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancer

Prabhakar Pitta Venkata, Sridharan Jayamohan, Yi He, Salvador Alejo, Jessica D. Johnson, Bridgitte E. Palacios, Uday P. Pratap, Yihong Chen, Zexuan Liu, Yi Zou, Zhao Lai, Takayoshi Suzuki, Suryavathi Viswanadhapalli, Susan T. Weintraub, Srinath Palakurthi, Philip T. Valente, Rajeshwar R. Tekmal, Edward R. Kost, Ratna K. Vadlamudi, Gangadhara R. Sareddy

Cancer Letters　Vol. 575　p. 216383-216383　2023/10　Research paper (scientific journal)

SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease

Noemi Sola-Sevilla, Alberto Mesa-Lombardo, Mikel Aleixo, Sara Expósito, Teresa Diaz-Perdigón, Amaya Azqueta, Farzad Zamani, Takayoshi Suzuki, Silvia Maioli, Francesca Eroli, Anna Matton, Maria J. Ramírez, Maite Solas, Rosa M. Tordera, Eduardo D. Martín, Elena Puerta

Journal of Neuroimmune Pharmacology　Vol. 18　No. 3　p. 529-550　2023/09/12　Research paper (scientific journal)

Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms

Anirban Mukherjee, Farzad Zamani, Takayoshi Suzuki

Journal of Medicinal Chemistry　Vol. 66　No. 17　p. 11672-11700　2023/08/31　Research paper (scientific journal)

Origin of the kinetic <scp>HDAC2</scp>‐selectivity of an <scp>HDAC</scp> inhibitor

Hirokazu Mishima, Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki, Naoya Asada, Ken‐ichi Kusakabe, Yuko Okamoto

Journal of Computational Chemistry　Vol. 44　No. 18　p. 1604-1609　2023/04/19　Research paper (scientific journal)

Catalytic asymmetric synthesis of (−)-arctigenin using a chiral Ir complex

Rui Jiang, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Takeyuki Suzuki

Tetrahedron　Vol. 133　p. 133287-133287　2023/03　Research paper (scientific journal)

Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma

Salvador Alejo, Bridgitte E Palacios, Prabhakar Pitta Venkata, Yi He, Wenjing Li, Jessica D Johnson, Yihong Chen, Sridharan Jayamohan, Uday P Pratap, Kyra Clarke, Yi Zou, Yingli Lv, Korri Weldon, Suryavathi Viswanadhapalli, Zhao Lai, Zhenqing Ye, Yidong Chen, Andrea R Gilbert, Takayoshi Suzuki, Rajeshwar R Tekmal, Weixing Zhao, Siyuan Zheng, Ratna K Vadlamudi, Andrew J Brenner, Gangadhara R Sareddy

Neuro-Oncology　Vol. 25　No. 7　p. 1249-1261　2023/01/18　Research paper (scientific journal)

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action

Yuki Kitao, Tadataka Saito, Satoshi Watanabe, Yasuhiro Ohe, Koichi Takahashi, Tatsuo Akaki, Tsuyoshi Adachi, Satoki Doi, Kenji Yamanaka, Yasutaka Murai, Makoto Oba, Takayoshi Suzuki

Bioorganic &amp; Medicinal Chemistry Letters　Vol. 80　p. 129110-129110　2023/01　Research paper (scientific journal)

Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates

Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E. Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, Mie Morita, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki

ACS Medicinal Chemistry Letters　Vol. 13　No. 10　p. 1568-1573　2022/10/13　Research paper (scientific journal)

A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production.

Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase, Daisuke Takahashi

Biological & pharmaceutical bulletin　Vol. 45　No. 9　p. 1364-1372　2022/09　Research paper (scientific journal)

Medicinal Chemistry Research on Targeting Epigenetic Complexes

Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki

Journal of Synthetic Organic Chemistry, Japan　Vol. 80　No. 7　p. 664-675　2022/07/01　Research paper (scientific journal)

Novel histone modifications in microglia derived from a mouse model of chronic pain

Ping Zhang, Jennifer Guergues, Amy R. Alleyne, Thomas J. Cirino, Owen Nadeau, Ariana M. Figueroa, Heather M. Stacy, Takayoshi Suzuki, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu

PROTEOMICS　Vol. 22　No. 9　p. 2100137-2100137　2022/05　Research paper (scientific journal)

Using α- and β-Epimerizations of cis-2,3-Bis(hydroxymethyl)-γ-butyrolactone for the Synthesis of Both Enantiomers of Enterolactone

Rui Jiang, Ismiyarto, Tsukasa Abe, Da-Yang Zhou, Kaori Asano, Takayoshi Suzuki, Hiroaki Sasai, Takeyuki Suzuki

The Journal of Organic Chemistry　Vol. 87　No. 8　p. 5051-5056　2022/04/15　Research paper (scientific journal)

Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).

Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki

Chemical communications (Cambridge, England)　Vol. 58　No. 29　p. 4635-4638　2022/04/07　Research paper (scientific journal)

Recent progress on small molecules targeting epigenetic complexes.

Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Takayoshi Suzuki

Current opinion in chemical biology　Vol. 67　p. 102130-102130　2022/04　Research paper (scientific journal)

KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer

Prabhakar Pitta Venkata, Yihong Chen, Salvador Alejo, Yi He, Bridgitte E. Palacios, Ilanna Loeffel, Junhao Liu, Uday P. Pratap, Gabrielle Gray, Sureshkumar Mulampurath Achuthan Pillai, Yi Zou, Zhao Lai, Takayoshi Suzuki, Suryavathi Viswanadhapalli, Srinath Palakurthi, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Edward Kost, Gangadhara R. Sareddy

Cancer Letters　Vol. 524　p. 219-231　2022/01　Research paper (scientific journal)

Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach

Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki

Journal of Medicinal Chemistry　Vol. 64　No. 21　p. 15810-15824　2021/11/03　Research paper (scientific journal)

ウィルスがもたらすヘテロクロマチン破綻と新たなエピジェネティック 発癌機構「エンハンサー侵襲」の発見

岡部 篤史, Huang Kie Kyon, 松坂 恵介, 福世 真樹, 星居 孝之, 臼井 源紀, 関 元昭, 眞野 恭伸, Rahmutulla Bahityar, 神田 輝, 鈴木 孝禎, 牛久 哲男, 深山 正久, Tan Patrick, 金田 篤志

日本癌学会総会記事　Vol. 80回　p. [YIA-4]　2021/09

Ca 2+ ‐activated K + channel K Ca 1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models

Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E. Elboray, Takayoshi Suzuki

Cancer Science　Vol. 112　No. 9　p. 3769-3783　2021/09　Research paper (scientific journal)

Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group.

Takashi Kurohara, Keita Tanaka, Daisuke Takahashi, Satoshi Ueda, Yasunobu Yamashita, Yuri Takada, Hirokazu Takeshima, Shengwang Yu, Yukihiro Itoh, Koji Hase, Takayoshi Suzuki

Chembiochem : a European journal of chemical biology　Vol. 22　No. 22　p. 3158-3163　2021/07/05　Research paper (scientific journal)

Synthetic RNA Modulators in Drug Discovery

Farzad Zamani, Takayoshi Suzuki

Journal of Medicinal Chemistry　Vol. 64　No. 11　p. 7110-7155　2021/06/10　Research paper (scientific journal)

Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders

Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yasunobu Yamashita, Takashi Kurohara, Yuka Miyake, Makoto Oba, Takayoshi Suzuki

ChemMedChem　Vol. 16　No. 10　p. 1609-1618　2021/05/18　Research paper (scientific journal)

Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors

Piyush Gediya, Vivek K. Vyas, Vincenzo Carafa, Nikum Sitwala, Laura Della Torre, Angelita Poziello, Takashi Kurohara, Takayoshi Suzuki, Vinod Sanna, Varalakshmi Raguraman, K. Suthindhiran, Debarpan Ghosh, Dhiraj Bhatia, Lucia Altucci, Manjunath D. Ghate

Bioorganic Chemistry　Vol. 110　p. 104801-104801　2021/05　Research paper (scientific journal)

Catalytic enantioselective intramolecular Tishchenko reaction of meso-dialdehyde: synthesis of (S)-cedarmycins

Ismiyarto, Nobuki Kishi, Yuki Adachi, Rui Jiang, Takahiro Doi, Da-Yang Zhou, Kaori Asano, Yasushi Obora, Takayoshi Suzuki, Hiroaki Sasai, Takeyuki Suzuki

RSC Advances　Vol. 11　No. 19　p. 11606-11609　2021　Research paper (scientific journal)

精巣悪性腫瘍に対するヒストン脱メチル化酵素LSD1阻害剤の治療効果の検討

惠谷 俊紀, 内木 拓, 永井 隆, 野崎 哲史, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 戸澤 啓一, 鈴木 孝禎, 安井 孝周

日本泌尿器科学会総会　Vol. 108回　p. 808-808　2020/12

N⁺-C-H…O Hydrogen Bonds in Protein-Ligand Complexes and their Application to Drug Design

Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki

Journal of Synthetic Organic Chemistry, Japan　Vol. 78　No. 12　p. 1151-1162　2020/12/01　Research paper (scientific journal)

KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer

Mei Zhou, Prabhakar Pitta Venkata, Suryavathi Viswanadhapalli, Bridgitte Palacios, Salvador Alejo, Yihong Chen, Yi He, Uday P. Pratap, Junhao Liu, Yi Zou, Zhao Lai, Takayoshi Suzuki, Andrew J. Brenner, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Gangadhara R. Sareddy

Breast Cancer Research and Treatment　2020/10/14　Research paper (scientific journal)

Cross-species chromatin interactions drive transcriptional rewiring in Epstein–Barr virus–positive gastric adenocarcinoma

Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Manjie Xing, Xuewen Ong, Takayuki Hoshii, Genki Usui, Motoaki Seki, Yasunobu Mano, Bahityar Rahmutulla, Teru Kanda, Takayoshi Suzuki, Sun Young Rha, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda

Nature Genetics　Vol. 52　No. 9　p. 919-930　2020/09　Research paper (scientific journal)

エピジェネティック酵素LSD1に対する選択的阻害剤を用いた癌性疼痛新規治療法の開発

惠谷 俊紀, 内木 拓, 内木 綾, 永井 隆, 野崎 哲史, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 鈴木 孝禎, 高橋 智, 安井 孝周

泌尿器外科　Vol. 33　No. 8　p. 1033-1036　2020/08

エピジェネティック酵素LSD1に対する選択的阻害剤を用いた癌性疼痛新規治療法の開発

惠谷 俊紀, 内木 拓, 内木 綾, 永井 隆, 野崎 哲史, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 鈴木 孝禎, 高橋 智, 安井 孝周

泌尿器外科　Vol. 33　No. 8　p. 1033-1036　2020/08

Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist

Hiroaki Kito, Haruka Morihiro, Yuka Sakakibara, Kyoko Endo, Junko Kajikuri, Takayoshi Suzuki, Susumu Ohya

American Journal of Physiology-Cell Physiology　Vol. 319　No. 2　p. C345-C358　2020/08/01　Research paper (scientific journal)

Selective lysine‐specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis

Satoshi Nozaki, Taku Naiki, Aya Naiki‐Ito, Shoichiro Iwatsuki, Tomoki Takeda, Toshiki Etani, Takashi Nagai, Keitaro Iida, Hiroyuki Kato, Takayoshi Suzuki, Satoru Takahashi, Yukihiro Umemoto, Takahiro Yasui

Andrology　2020/07/15　Research paper (scientific journal)

Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor

Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki

ACS CATALYSIS　Vol. 10　No. 10　p. 5383-5392　2020/05　Research paper (scientific journal)

LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia

Goichi Tatsumi, Masahiro Kawahara, Ryusuke Yamamoto, Masakatsu Hishizawa, Katsuyuki Kito, Takayoshi Suzuki, Akifumi Takaori-Kondo, Akira Andoh

Leukemia　Vol. 34　No. 3　p. 746-758　2020/03　Research paper (scientific journal)

Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.

Shusuke Ogihara, Toru Komatsu, Yukihiro Itoh, Yuka Miyake, Takayoshi Suzuki, Kouichi Yanagi, Yusuke Kimura, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuteru Urano

Journal of the American Chemical Society　Vol. 142　No. 1　p. 21-26　2020/01/08　Research paper (scientific journal)

Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor

Keng Yoon Yeong, Kooi Yeong Khaw, Yukari Takahashi, Yukihiro Itoh, Vikneswaran Murugaiyah, Takayoshi Suzuki

Bioorganic Chemistry　Vol. 94　p. 103403-103403　2020/01　Research paper (scientific journal)

Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence accelerated mouse model

Teresa Diaz-Perdigon, Borja Belloch, Ana Ricobaraza, Elghareeb Elboray, Takayoshi Suzuki, Rosa Tordera, Elena Puerta.

Neuropsychopharmacolgy　Vol. 45　No. 2　p. 347-357　2020/01

Possible Contribution of Inflammation-Associated Hypoxia to Increased K2P5.1 K+ Channel Expression in CD4+ T Cells of the Mouse Model for Inflammatory Bowel Disease

Kyoko Endo, Hiroaki Kito, Ryo Tanaka, Junko Kajikuri, Satoshi Tanaka, Elghareeb E. Elboray, Takayoshi Suzuki, Susumu Ohya

International Journal of Molecular Sciences　Vol. 21　No. 1　p. 38-38　2019/12/19　Research paper (scientific journal)

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD⁺-Binding Site

Paolo Mellini, Yukihiro Itoh, Elghareeb E. Elboray, Hiroki Tsumoto, Ying Li, Miki Suzuki, Yukari Takahashi, Toshifumi Tojo, Takashi Kurohara, Yuka Miyake, Yuri Miura, Yuki Kitao, Masayuki Kotoku, Tetsuya Iida, Takayoshi Suzuki

Journal of Medicinal Chemistry　Vol. 62　No. 12　p. 5844-5862　2019/06/27　Research paper (scientific journal)

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors

Pattaporn Jaikhan, Benjaporn Buranrat, Yukihiro Itoh, Jiranan Chotitumnavee, Takashi Kurohara, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry Letters　Vol. 29　No. 10　p. 1173-1176　2019/05/15　Research paper (scientific journal)

Genome‑wide ChIP‑seq data with a transcriptome analysis reveals the groups of genes regulated by histone demethylase LSD1 inhibition in esophageal squamous cell carcinoma cells

Isamu Hoshino, Masahiko Takahashi, Yasunori Akutsu, Kentaro Murakami, Yasunori Matsumoto, Hiroshi Suito, Nobufumi Sekino, Aki Komatsu, Keiko Iida, Takayoshi Suzuki, Itsuro Inoue, Fumitaka Ishige, Yosuke Iwatate, Hisahiro Matsubara

Oncology Letters　Vol. 18　No. 1　p. 872-881　2019/05/13　Research paper (scientific journal)

精巣悪性腫瘍に対するヒストン脱メチル化酵素LSD1阻害剤の治療効果に関する基礎的研究

惠谷 俊紀, 内木 拓, 永井 隆, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 戸澤 啓一, 鈴木 孝禎, 安井 孝周

日本泌尿器科学会総会　Vol. 107回　p. AOP-034　2019/04

NCL1, A Highly Selective Lysine-Specific Demethylase 1 Inhibitor, Suppresses Castration-Resistant Prostate Cancer Growth via Regulation of Apoptosis and Autophagy.

Toshiki Etani, Taku Naiki, Aya Naiki-Ito, Takayoshi Suzuki, Keitaro Iida, Satoshi Nozaki, Hiroyuki Kato, Yuko Nagayasu, Shugo Suzuki, Noriyasu Kawai, Takahiro Yasui, Satoru Takahashi

Journal of clinical medicine　Vol. 8　No. 4　2019/03/31　Research paper (scientific journal)

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy

Yuka Miyake, Yukihiro Itoh, Atsushi Hatanaka, Yoshinori Suzuma, Miki Suzuki, Hidehiko Kodama, Yoshinobu Arai, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry　Vol. 27　No. 6　p. 1119-1129　2019/03/15　Research paper (scientific journal)

N+-C-H···O Hydrogen bonds in protein-ligand complexes.

Yukihiro Itoh, Yusuke Nakashima, Shuichiro Tsukamoto, Takashi Kurohara, Miki Suzuki, Yoshitake Sakae, Masayuki Oda, Yuko Okamoto, Takayoshi Suzuki

Scientific reports　Vol. 9　No. 1　p. 767-767　2019/01/25　Research paper (scientific journal)

Synthesis of LSD1 Inhibitor-Pyrrole-Imidazole Polyamide Conjugates for Region-Specific Alterations of Histone Modification

Tetsuhiro Nemoto, Rui Qin, Shihori Takayanagi, Yusuke Kondo, Jiawei Li, Naoki Shiga, Masaya Nakajima, Ken-ichi Shinohara, Natsumi Yoda, Takayoshi Suzuki, Atsushi Kaneda

HETEROCYCLES　Vol. 99　No. 2　p. 891-891　2019　Research paper (scientific journal)

HDAC8 inhibition ameliorates pulmonary fibrosis

Shigeki Saito, Yan Zhuang, Takayoshi Suzuki, Yosuke Ota, Marjorie E. Bateman, Ala L. Alkhatib, Gilbert F. Morris, Joseph A. Lasky

American Journal of Physiology-Lung Cellular and Molecular Physiology　Vol. 316　No. 1　p. L175-L186　2019/01/01　Research paper (scientific journal)

Design, synthesis, and biological evaluation of a conjugate of 5-fluorouracil and an LSD1 inhibitor

Yosuke Ota, Arisa Nakamura, Elghareeb E. Elboray, Yukihiro Itoh, Takayoshi Suzuki

Chemical and Pharmaceutical Bulletin　Vol. 67　No. 3　p. 192-195　2019　Research paper (scientific journal)

Discovery of the Second Generation RORg Inhibitors Composed of an Azole Scaffold.

Kotoku M, Maeba T, Fujioka S, Yokota M, Seki N, Ito K, Suwa Y, Ikenogami T, Hirata K, Hase Y, Katsuda Y, Miyagawa N, Arita K, Asahina K, Noguchi M, Nomura A, Doi S, Adachi T, Crowe P, Tao H, Thacher S, Hashimoto H, Suzuki T, Shiozaki M

J. Med. Chem.　Vol. 62　p. 2837-2842　2019　Research paper (scientific journal)

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines

Tomohiro Kozako, Paolo Mellini, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda, Takayoshi Suzuki

BMC Cancer　Vol. 18　No. 1　2018/12　Research paper (scientific journal)

Histone Deacetylases Enhance Ca2+-Activated K+ Channel KCa3.1 Expression in Murine Inflammatory CD4+ T Cells

Miki Matsui, Kyoko Terasawa, Junko Kajikuri, Hiroaki Kito, Kyoko Endo, Pattaporn Jaikhan, Takayoshi Suzuki, Susumu Ohya

International Journal of Molecular Sciences　Vol. 19　No. 10　p. 2942-2942　2018/09/27　Research paper (scientific journal)

Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide

Kokiladevi Alagarswamy, Ken-Ichi Shinohara, Shihori Takayanagi, Masaki Fukuyo, Atsushi Okabe, Bahityar Rahmutulla, Natsumi Yoda, Rui Qin, Naoki Shiga, Masahiro Sugiura, Hiroaki Sato, Kazuko Kita, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda

Oncotarget　Vol. 9　No. 50　p. 29316-29335　2018/06/29　Research paper (scientific journal)

Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells

Ryusuke Yamamoto, Masahiro Kawahara, Shinji Ito, Junko Satoh, Goichi Tatsumi, Masakatsu Hishizawa, Takayoshi Suzuki, Akira Andoh

Oncotarget　Vol. 9　No. 30　p. 21007-21021　2018/04/20　Research paper (scientific journal)

エピゲノム変化を介した去勢抵抗性前立腺癌におけるオートファジー制御メカニズムの解明と新規治療法の開発

惠谷 俊紀, 内木 拓, 内木 綾, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 高橋 智, 鈴木 孝禎, 安井 孝周

日本泌尿器科学会総会　Vol. 106回　p. AL-5　2018/04

Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations

Shuichiro Tsukamoto, Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto

Journal of Chemical Physics　Vol. 148　No. 12　2018/03/28　Research paper (scientific journal)

HDAC8 regulates neural differentiation through embryoid body formation in P19 cells

Syouichi Katayama, Atsushi Morii, Juliet O. Makanga, Takayoshi Suzuki, Naoki Miyata, Tetsuya Inazu

Biochemical and Biophysical Research Communications　Vol. 498　No. 1　p. 45-51　2018/03/25　Research paper (scientific journal)

Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors

Yosuke Ota, Shin Miyamura, Misaho Araki, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Kenichiro Itami, Junichiro Yamaguchi, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry　Vol. 26　No. 3　p. 775-785　2018/02/01　Research paper (scientific journal)

Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors

Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry Letters　Vol. 28　No. 2　p. 167-169　2018/01/15　Research paper (scientific journal)

Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Yosuke Ota, Taeko Kakizawa, Yukihiro Itoh, Takayoshi Suzuki

Molecules　Vol. 23　No. 5　p. 1099-1099　2018　Research paper (scientific journal)

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos-Morales E, Da Veiga C, Kalinin D, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce RJ, Jung M, Sippl W, Romier C

J. Med. Chem.　Vol. 61　p. 10000-10016　2018　Research paper (scientific journal)

A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers

N. Sugino, M. Kawahara, G. Tatsumi, A. Kanai, H. Matsui, R. Yamamoto, Y. Nagai, S. Fujii, Y. Shimazu, M. Hishizawa, T. Inaba, A. Andoh, T. Suzuki, A. Takaori-Kondo

LEUKEMIA　Vol. 31　No. 11　p. 2303-2314　2017/11　Research paper (scientific journal)

ヒストン脱メチル化酵素LSD1の新規阻害剤の胚細胞腫瘍への治療効果

惠谷 俊紀, 内木 拓, 永井 隆, 田中 勇太朗, 飯田 啓太郎, 安藤 亮介, 河合 憲康, 高橋 智, 鈴木 孝禎, 安井 孝周

日本癌学会総会記事　Vol. 76回　p. P-3210　2017/09

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

Mercedes Erburu, Irene Muñoz-Cobo, Teresa Diaz-Perdigon, Paolo Mellini, Takayoshi Suzuki, Elena Puerta, Rosa M. Tordera

Neuropharmacology　Vol. 117　p. 195-208　2017/05/01　Research paper (scientific journal)

Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway

G. R. Sareddy, S. Viswanadhapalli, P. Surapaneni, T. Suzuki, A. Brenner, R. K. Vadlamudi

ONCOGENE　Vol. 36　No. 17　p. 2423-2434　2017/04　Research paper (scientific journal)

Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors

Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki

Peptide Science 2016　p. 165-166　2017/02/26　Research paper (bulletin of university, research institution)

Transcriptional repression of HER2 by ANO1 Cl- channel inhibition in human breast cancer cells with resistance to trastuzumab

Mayu Fujimoto, Takahiro Inoue, Hiroaki Kito, Satomi Niwa, Takayoshi Suzuki, Katsuhiko Muraki, Susumu Ohya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 482　No. 1　p. 188-194　2017/01　Research paper (scientific journal)

“Drug” discovery with the help of organic chemistry

Yukihiro Itoh, Takayoshi Suzuki

Yakugaku Zasshi　Vol. 137　No. 3　p. 283-292　2017

Potent mechanism-based sirtuin-2-selective inhibition by an: In situ -generated occupant of the substrate-binding site, "selectivity pocket" and NAD⁺-binding site

Paolo Mellini, Yukihiro Itoh, Hiroki Tsumoto, Ying Li, Miki Suzuki, Natsuko Tokuda, Taeko Kakizawa, Yuri Miura, Jun Takeuchi, Maija Lahtela-Kakkonen, Takayoshi Suzuki

Chemical Science　Vol. 8　No. 9　p. 6400-6408　2017　Research paper (scientific journal)

CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene

Shusaku Uchida, Brett J. W. Teubner, Charles Hevi, Kumiko Hara, Ayumi Kobayashi, Rutu M. Dave, Tatsushi Shintaku, Pattaporn Jaikhan, Hirotaka Yamagata, Takayoshi Suzuki, Yoshifumi Watanabe, Stanislav S. Zakharenko, Gleb P. Shumyatsky

CELL REPORTS　Vol. 18　No. 2　p. 352-366　2017/01　Research paper (scientific journal)

Down-Regulation of Ca2+-Activated K+ Channel K(Ca)1.1 in Human Breast Cancer MDA-MB-453 Cells Treated with Vitamin D Receptor Agonists

Anowara Khatun, Mayu Fujimoto, Hiroaki Kito, Satomi Niwa, Takayoshi Suzuki, Susumu Ohya

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES　Vol. 17　No. 12　2016/12　Research paper (scientific journal)

LSD1により抑制されたGFI1エンハンサーはAMLの骨髄分化障害に重要である

辰巳 剛一, 河原 真大, 松井 啓隆, 菱澤 方勝, 稲葉 俊哉, 鈴木 孝禎, 高折 晃史

日本癌学会総会記事　Vol. 75回　p. E-1114　2016/10

Hippocampal microRNA-124 enhances chronic stress resilience in mice

Fumihiro Higuchi, Shusaku Uchida, Hirotaka Yamagata, Naoko Abe-Higuchi, Teruyuki Hobara, Kumiko Hara, Ayumi Kobayashi, Tatsushi Shintaku, Yukihiro Itoh, Takayoshi Suzuki, Yoshifumi Watanabe

Journal of Neuroscience　Vol. 36　No. 27　p. 7253-7267　2016/07/06　Research paper (scientific journal)

Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis

Xiaoai Wu, Zhen Fang, Bo Yang, Lei Zhong, Qiuyuan Yang, Chunhui Zhang, Shenzhen Huang, Rong Xiang, Takayoshi Suzuki, Lin-Li Li, Sheng-Yong Yang

Bioorganic and Medicinal Chemistry Letters　Vol. 26　No. 9　p. 2284-2288　2016/05/01　Research paper (scientific journal)

Downregulation of the Ca2+-activated K+channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells

Susumu Ohya, Saki Kanatsuka, Noriyuki Hatano, Hiroaki Kito, Azusa Matsui, Mayu Fujimoto, Sayo Matsuba, Satomi Niwa, Peng Zhan, Takayoshi Suzuki, Katsuhiko Muraki

Pharmacology Research & Perspectives　Vol. 4　No. 2　p. e00228-e00228　2016/04　Research paper (scientific journal)

Click Chemistryを用いたHDAC1/2選択的阻害薬の創製

東條 敏史, 伊藤 幸裕, 展 鵬, 太田 庸介, 鈴木 美紀, 内田 周作, 鈴木 孝禎

日本薬学会年会要旨集　Vol. 136年会　No. 2　p. 125-125　2016/03

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki

Journal of Medicinal Chemistry　Vol. 59　No. 4　p. 1531-1544　2016/02/25　Research paper (scientific journal)

Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide

Taeko Kakizawa, Tamio Mizukami, Yukihiro Itoh, Makoto Hasegawa, Ryuzo Sasaki, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry Letters　Vol. 26　No. 4　p. 1193-1195　2016/02/15　Research paper (scientific journal)

22aPS-113 Study on the selectivity of the epigenetic enzyme inhibitor by generalized-ensemble molecular dynamics simulations

Tsukamoto S., Sakae Y., Itoh Y., Suzuki T., Okamoto Y.

Meeting Abstracts of the Physical Society of Japan　Vol. 71　p. 3323-3323　2016

A drosophila model for screening antiobesity agents

Tran Thanh Men, Duong Ngoc Van Thanh, Masamitsu Yamaguchi, Takayoshi Suzuki, Gen Hattori, Masayuki Arii, Nguyen Tien Huy, Kaeko Kamei

BioMed Research International　Vol. 2016　2016　Research paper (scientific journal)

Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells

Isamu Hoshino, Yasunori Akutsu, Kentaro Murakami, Naoki Akanuma, Yuka Isozaki, Tetsuro Maruyama, Takeshi Toyozumi, Yasunori Matsumoto, Hiroshi Suito, Masahiko Takahashi, Nobufumi Sekino, Aki Komatsu, Takayoshi Suzuki, Hisahiro Matsubara

Annals of Surgical Oncology　Vol. 23　No. 1　p. 312-320　2016/01/01　Research paper (scientific journal)

Labial salivary gland biopsy for diagnosing immunoglobulin light chain amyloidosis: a retrospective analysis

Tomotaka Suzuki, Shigeru Kusumoto, Taro Yamashita, Arisa Masuda, Shiori Kinoshita, Takashi Yoshida, Fumiko Takami-Mori, Hisashi Takino, Asahi Ito, Masaki Ri, Takashi Ishida, Hirokazu Komatsu, Mitsuharu Ueda, Yukio Ando, Hiroshi Inagaki, Shinsuke Iida

ANNALS OF HEMATOLOGY　Vol. 95　No. 2　p. 279-285　2016/01　Research paper (scientific journal)

Molecular technology for controlling epigenetics: Regulation of histone acetylation and methylation by small molecules

Yukihiro Itoh, Takayoshi Suzuki

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry　Vol. 74　No. 5　p. 441-452　2016

False HDAC inhibition by aurone compound

Yukihiro Itoh, Miki Suzuki, Taiji Matsui, Yosuke Ota, Zi Hui, Kazunori Tsubaki, Takayoshi Suzuki

Chemical and Pharmaceutical Bulletin　Vol. 64　No. 8　p. 1124-1128　2016　Research paper (scientific journal)

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors

Shin Miyamura, Misaho Araki, Yosuke Ota, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi

Organic and Biomolecular Chemistry　Vol. 14　No. 36　p. 8576-8585　2016　Research paper (scientific journal)

Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen

Yosuke Ota, Yukihiro Itoh, Asako Kaise, Kiminori Ohta, Yasuyuki Endo, Mitsuharu Masuda, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki

Angewandte Chemie - International Edition　Vol. 55　No. 52　p. 16115-16118　2016　Research paper (scientific journal)

Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety

Hidehiko Nakagawa, Suguru Seike, Masatoshi Sugimoto, Naoya Ieda, Mitsuyasu Kawaguchi, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 25　No. 23　p. 5619-5624　2015/12　Research paper (scientific journal)

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

Peng Zhan, Yukihiro Itoh, Takayoshi Suzuki, Xinyong Liu

Journal of Medicinal Chemistry　Vol. 58　No. 19　p. 7611-7633　2015/10/08　Research paper (scientific journal)

A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section.

Naoya Ieda, Kazuhiro Hishikawa, Kei Eto, Kai Kitamura, Mitsuyasu Kawaguchi, Takayoshi Suzuki, Kiyoshi Fukuhara, Naoki Miyata, Toshiaki Furuta, Junichi Nabekura, Hidehiko Nakagawa

Bioorganic & medicinal chemistry letters　Vol. 25　No. 16　p. 3172-5　2015/08/15　Research paper (scientific journal)

Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells

Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Yuichiro Uchida, Ayako Kuroki, Akiyoshi Aikawa, Shin-Ichiro Honda, Naomichi Arima, Shinji Soeda

Scientific Reports　Vol. 5　2015/06/19　Research paper (scientific journal)

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells

Yukihiro Itoh, Hideyuki Sawada, Miki Suzuki, Toshifumi Tojo, Ryuzo Sasaki, Makoto Hasegawa, Tamio Mizukami, Takayoshi Suzuki

ACS Medicinal Chemistry Letters　Vol. 6　No. 6　p. 665-670　2015/06/11　Research paper (scientific journal)

Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange

Hiroki Tsumoto, Daisuke Ogasawara, Noritaka Hashii, Takayoshi Suzuki, Yoshihiro Akimoto, Tamao Endo, Yuri Miura

Bioorganic and Medicinal Chemistry Letters　Vol. 25　No. 13　p. 2645-2649　2015/05/30　Research paper (scientific journal)

Histone H3 peptide based LSD1-selective inhibitors

Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Hiroki Tsumoto, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry Letters　Vol. 25　No. 9　p. 1925-1928　2015/05/01　Research paper (scientific journal)

Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells

Samaya R. Krishnan, Binoj C. Nair, Gangadhara R. Sareddy, Sudipa Saha Roy, Mohan Natarajan, Takayoshi Suzuki, Yan Peng, Ganesh Raj, Ratna K. Vadlamudi

Breast Cancer Research and Treatment　Vol. 150　No. 3　p. 487-499　2015/04/01　Research paper (scientific journal)

Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1

Mohammed Naseer Ahmed Khan, Hiroki Tsumoto, Yukihiro Itoh, Yosuke Ota, Miki Suzuki, Daisuke Ogasawara, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki

MedChemComm　Vol. 6　No. 3　p. 407-412　2015/03/01　Research paper (scientific journal)

Elucidation of accelerated mechanism to differentiation of human induced pluripotent stem cells into hepatocyte-like cells and application to toxicity tests

SAKAMOTO Sakae, KURIKI Shunsuke, KONDO Yuki, IWAO Takahiro, DOI Takayoshi, SUZUKI Takayoshi, MIYATA Naoki, MATSUNAGA Tamihide

Annual Meeting of the Japanese Society of Toxicology　Vol. 42　p. P-244　2015

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

Toshiki Etani, Takayoshi Suzuki, Taku Naiki, Aya Naiki-Ito, Ryosuke Ando, Keitaro Iida, Noriyasu Kawai, Keiichi Tozawa, Naoki Miyata, Kenjiro Kohri, Satoru Takahashi

Oncotarget　Vol. 6　No. 5　p. 2865-2878　2015　Research paper (scientific journal)

A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 5　p. 2902-2918　2015/01　Research paper (scientific journal)

Visible light-induced nitric oxide release from a novel nitrobenzene derivative cross-conjugated with a coumarin fluorophore.

Kai Kitamura, Naoya Ieda, Kazuhiro Hishikawa, Takayoshi Suzuki, Naoki Miyata, Kiyoshi Fukuhara, Hidehiko Nakagawa

Bioorganic & medicinal chemistry letters　Vol. 24　No. 24　p. 5660-5662　2014/12/15　Research paper (scientific journal)

Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme

Raushan K. Singh, Takayoshi Suzuki, Tanmay Mandal, Narayanaganesh Balsubramanian, Manas Haldar, Dustin J. Mueller, Jerrod A. Strode, Gregory Cook, Sanku Mallik, D. K. Srivastava

Biochemistry　Vol. 53　No. 48　p. 7445-7458　2014/12/09　Research paper (scientific journal)

Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells

Sayo Matsuba, Satomi Niwa, Katsuhiko Muraki, Saki Kanatsuka, Yurika Nakazono, Noriyuki Hatano, Masanori Fujii, Peng Zhan, Takayoshi Suzuki, Susumu Ohya

Journal of Pharmacology and Experimental Therapeutics　Vol. 351　No. 3　p. 510-518　2014/12/01　Research paper (scientific journal)

Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates

Tatsuo Mano, Takayoshi Suzuki, Shoji Tsuji, Atsushi Iwata

PLoS ONE　Vol. 9　No. 11　2014/11/07　Research paper (scientific journal)

Recent advances in the structure-based rational design of TNKSIs

Peng Zhan, Yu'Ning Song, Yukihiro Itoh, Takayoshi Suzuki, Xinyong Liu

Molecular BioSystems　Vol. 10　No. 11　p. 2783-2799　2014/11/01

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells

Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga

PLoS ONE　Vol. 9　No. 8　2014/08/01　Research paper (scientific journal)

Late-stage C-H coupling enables rapid identification of HDAC inhibitors: Synthesis and evaluation of NCH-31 analogues

Hiromi Sekizawa, Kazuma Amaike, Yukihiro Itoh, Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi

ACS Medicinal Chemistry Letters　Vol. 5　No. 5　p. 582-586　2014/05/08　Research paper (scientific journal)

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

Andrew E. Tee, Dora Ling, Charlotte Nelson, Bernard Atmadibrata, Marcel E. Dinger, Ning Xu, Tamio Mizukami, Pei Y. Liu, Bing Liu, Belamy Cheung, Eddy Pasquier, Michelle Haber, Murray D. Norris, Takayoshi Suzuki, Glenn M. Marshall, Tao Liu

ONCOTARGET　Vol. 5　No. 7　p. 1793-1804　2014/04　Research paper (scientific journal)

Identification of novel SIRT2-selective inhibitors using a click chemistry approach

Prima R. Tatum, Hideyuki Sawada, Yosuke Ota, Yukihiro Itoh, Peng Zhan, Naoya Ieda, Hidehiko Nakagawa, Naoki Miyata, Takayoshi Suzuki

Bioorganic and Medicinal Chemistry Letters　Vol. 24　No. 8　p. 1871-1874　2014/04　Research paper (scientific journal)

Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors

Takayoshi Suzuki, Nobusuke Muto, Masashige Bando, Yukihiro Itoh, Ayako Masaki, Masaki Ri, Yosuke Ota, Hidehiko Nakagawa, Shinsuke Iida, Katsuhiko Shirahige, Naoki Miyata

ChemMedChem　Vol. 9　No. 3　p. 657-664　2014/03　Research paper (scientific journal)

エピジェネティクスを操る小分子化合物

伊藤 幸裕, 鈴木 孝禎

ファルマシア　Vol. 50　No. 11　p. 1107-1111　2014

Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2)

Koshiki Mino, Satoshi Nishimura, Shogo Ninomiya, Hiroshi Tujii, Yasumasa Matsumori, Mie Tsuchida, Miho Hosoi, Koichi Koseki, Shuichi Wada, Makoto Hasegawa, Ryuzo Sasaki, Yukie Murakami-Yamaguchi, Hiroshi Narita, Takayoshi Suzuki, Naoki Miyata, Tamio Mizukami

Bioscience, Biotechnology and Biochemistry　Vol. 78　No. 6　p. 1010-1017　2014　Research paper (scientific journal)

Target-guided synthesis: Medicinal chemistry strategy to allow target enzymes themselves to synthesize their own inhibitors

Yukihiro Itoh, Naoki Miyata, Takayoshi Suzuki

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry　Vol. 72　No. 6　p. 702-716　2014

Synthesis, LSD1 inhibitory activity, and LSD1 Binding model of optically pure lysine-PCPA conjugates

Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki

Computational and Structural Biotechnology Journal　Vol. 9　No. 14　2014　Research paper (scientific journal)

Stereodivergent Synthesis of Arylcyclopropylamines by Sequential C-H Borylation and Suzuki-Miyaura Coupling” Shin Miyamura, Misaho Araki, Takayoshi Suzuki, Junichiro Yamaguchi, and Kenichiro Itami.

Shin Miyamura, Misaho Araki, Takayoshi Suzuki, Junichiro Yamaguchi, Kenichiro Itami

Angew. Chem. Int. Ed.　Vol. 53　p. 846-851　2014　Research paper (scientific journal)

Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

Naoki Fukushima, Naoya Ieda, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Takayoshi Suzuki, Naoki Miyata, Hidehiko Nakagawa

CHEMICAL COMMUNICATIONS　Vol. 50　No. 5　p. 587-589　2014　Research paper (scientific journal)

Fine spatiotemporal control of nitric oxide release by infrared pulse-laser irradiation of a photolabile donor.

Hidehiko Nakagawa, Kazuhiro Hishikawa, Kei Eto, Naoya Ieda, Tomotaka Namikawa, Kenji Kamada, Takayoshi Suzuki, Naoki Miyata, Jun-ichi Nabekura

ACS chemical biology　Vol. 8　No. 11　p. 2493-500　2013/11/15　Research paper (scientific journal)

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

Takayoshi Suzuki, Hiroki Ozasa, Yukihiro Itoh, Peng Zhan, Hideyuki Sawada, Koshiki Mino, Louise Walport, Rei Ohkubo, Akane Kawamura, Masato Yonezawa, Yuichi Tsukada, Anthony Tumber, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Christopher J. Schofield, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 56　No. 18　p. 7222-7231　2013/09/26　Research paper (scientific journal)

Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation

Yuji Matsuya, Yuta Kobayashi, Sayumi Uchida, Yukihiro Itoh, Hideyuki Sawada, Takayoshi Suzuki, Naoki Miyata, Kenji Sugimoto, Naoki Toyooka

Bioorganic and Medicinal Chemistry Letters　Vol. 23　No. 17　p. 4907-4910　2013/09/01　Research paper (scientific journal)

Lysine-specific demethylase 1-selective inactivators: Protein-targeted drug delivery mechanism

Daisuke Ogasawara, Yukihiro Itoh, Hiroki Tsumoto, Taeko Kakizawa, Koshiki Mino, Kiyoshi Fukuhara, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki

Angewandte Chemie - International Edition　Vol. 52　No. 33　p. 8620-8624　2013/08/12　Research paper (scientific journal)

A Reductant-Resistant and Metal-Free Fluorescent Probe for Nitroxyl Applicable to Living Cells

Kodai Kawai, Naoya Ieda, Kazuyuki Aizawa, Takayoshi Suzuki, Naoki Miyata, Hidehiko Nakagawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 135　No. 34　p. 12690-12696　2013/08　Research paper (scientific journal)

Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto, Naoki Miyata

PLoS ONE　Vol. 8　No. 7　2013/07/23　Research paper (scientific journal)

An Overview of Phenylcyclopropylamine Derivatives: Biochemical and Biological Significance and Recent Developments

Mohammed Naseer Ahmed Khan, Takayoshi Suzuki, Naoki Miyata

Medicinal Research Reviews　Vol. 33　No. 4　p. 873-910　2013/07　Research paper (scientific journal)

Small-molecular modulators of cancer-associated epigenetic mechanisms

Yukihiro Itoh, Takayoshi Suzuki, Naoki Miyata

Molecular BioSystems　Vol. 9　No. 5　p. 873-896　2013/05

Successful salvage therapy using lenalidomide in a patient with relapsed multiple myeloma after allogeneic hematopoietic stem cell transplantation

Tomotaka Suzuki, Shigeru Kusumoto, Tatsuya Yoshida, Fumiko Mori, Asahi Ito, Masaki Ri, Takashi Ishida, Hirokazu Komatsu, Akio Niimi, Shinsuke Iida

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 97　No. 4　p. 540-543　2013/04　Research paper (scientific journal)

Piloty's acid derivative with improved nitroxyl-releasing characteristics

Kazuyuki Aizawa, Hidehiko Nakagawa, Kazuya Matsuo, Kodai Kawai, Naoya Ieda, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 23　No. 8　p. 2340-2343　2013/04　Research paper (scientific journal)

FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models

Masato Takeuchi, Akira Hirasawa, Takafumi Hara, Ikuo Kimura, Tatsuya Hirano, Takayoshi Suzuki, Naoki Miyata, Takeo Awaji, Masaji Ishiguro, Gozoh Tsujimoto

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 168　No. 7　p. 1570-1583　2013/04　Research paper (scientific journal)

KDM1 is a novel therapeutic target for the treatment of gliomas

Gangadhara R. Sareddy, Binoj C. Nair, Samaya K. Krishnan, Vijay K. Gonugunta, Quan-guang Zhang, Takayoshi Suzuki, Naoki Miyata, Andrew J. Brenner, Darrell W. Brann, Ratna K. Vadlamudi

Oncotarget　Vol. 4　No. 1　p. 18-28　2013　Research paper (scientific journal)

The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma

Kristian W. Pajtler, Christina Weingarten, Theresa Thor, Annette Kunkele, Lukas C. Heukamp, Reinhard Buttner, Takayoshi Suzuki, Naoki Miyata, Michael Grotzer, Anja Rieb, Annika Sprussel, Angelika Eggert, Alexander Schramm, Johannes H. Schulte

ACTA NEUROPATHOLOGICA COMMUNICATIONS　Vol. 1　2013　Research paper (scientific journal)

Lysin-specific histone demethylase 1 (LSD1/KDM1A) qualifies as promising new epigenetic therapy target in medulloblastoma

Kristian W. Pajtler, Christina Weingarten, Theresa Thor, Annette Kuenkele, Lukas C. Heukamp, Reinhard Buttner, Takayoshi Suzuki, Naoki Miyata, Michael Grotzer, Anja Rieb, Annika Sprussel, Angelika Eggert, Alexander Schramm, Johannes H. Schulte

Acta Neuropathologica Communications　Vol. 1　2013　Research paper (scientific journal)

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

Takayoshi Suzuki, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 55　No. 22　p. 9562-9575　2012/11/26　Research paper (scientific journal)

Cell-Autonomous Enhancement of Glutamate-Uptake by Female Astrocytes

Yosuke Morizawa, Kaoru Sato, Junpei Takaki, Asami Kawasaki, Keisuke Shibata, Takeshi Suzuki, Shigeru Ohta, Schuichi Koizumi

CELLULAR AND MOLECULAR NEUROBIOLOGY　Vol. 32　No. 6　p. 953-956　2012/08　Research paper (scientific journal)

Photoinduced Upregulation of Calcitonin Gene-Related Peptide in A549 Cells through HNO Release from a Hydrophilic Photocontrollable HNO Donor

Kazuya Matsuo, Hidehiko Nakagawa, Yusuke Adachi, Eri Kameda, Kazuyuki Aizawa, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 60　No. 8　p. 1055-1062　2012/08　Research paper (scientific journal)

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Takayoshi Suzuki, Mohammed Naseer Ahmed Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 55　No. 12　p. 5760-5773　2012/06/28　Research paper (scientific journal)

Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells

Mamiko Ikeda, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 22　No. 5　p. 1949-1952　2012/03　Research paper (scientific journal)

Loss of deacetylation activity of Hdac6 affects emotional behavior in mice

Masahide Fukada, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Ramona M. Rodriguiz, William C. Wetsel, Tso-Pang Yao, Yoshiharu Kawaguchi

PLoS ONE　Vol. 7　No. 2　2012/02/06　Research paper (scientific journal)

Photocontrollable Peroxynitrite Generator Based on N-Methyl-N-nitrosoaminophenol for Cellular Application

Naoya Ieda, Hidehiko Nakagawa, Tao Peng, Dan Yang, Takayoshi Suzuki, Naoki Miyata

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 134　No. 5　p. 2563-2568　2012/02　Research paper (scientific journal)

Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

Valerie Cortez, Monica Mann, Seshidhar Tekmal, Takayoshi Suzuki, Naoki Miyata, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K. Sood, Ratna K. Vadlamudi

BREAST CANCER RESEARCH　Vol. 14　No. 4　2012　Research paper (scientific journal)

Lysine Demethylases Inhibitors

Takayoshi Suzuki, Naoki Miyata

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 54　No. 24　p. 8236-8250　2011/12　Research paper (scientific journal)

Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation.

Naoya Ieda, Hidehiko Nakagawa, Taeko Horinouchi, Tao Peng, Dan Yang, Hiroki Tsumoto, Takayoshi Suzuki, Kiyoshi Fukuhara, Naoki Miyata

Chemical communications (Cambridge, England)　Vol. 47　No. 22　p. 6449-51　2011/06/14　Research paper (scientific journal)

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor

Daisuke Ogasawara, Takayoshi Suzuki, Koshiki Mino, Rie Ueda, Mohammed Naseer Ahmed Khan, Takuya Matsubara, Koichi Koseki, Makoto Hasegawa, Ryuzo Sasaki, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 19　No. 12　p. 3702-3708　2011/06　Research paper (scientific journal)

Photoinduced nitric oxide release from a nitrobenzene derivative in mitochondria.

Taeko Horinouchi, Hidehiko Nakagawa, Takayoshi Suzuki, Kiyoshi Fukuhara, Naoki Miyata

Chemistry (Weinheim an der Bergstrasse, Germany)　Vol. 17　No. 17　p. 4809-13　2011/04/18　Research paper (scientific journal)

Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression

Ann Florence B. Victoriano, Kenichi Imai, Hiroaki Togami, Takaharu Ueno, Kaori Asamitsu, Takayoshi Suzuki, Naoki Miyata, Kuniyasu Ochiai, Takashi Okamoto

FEBS Letters　Vol. 585　No. 7　p. 1103-1111　2011/04/06　Research paper (scientific journal)

A novel mitochondria-localizing nitrobenzene derivative as a donor for photo-uncaging of nitric oxide.

Taeko Horinouchi, Hidehiko Nakagawa, Takayoshi Suzuki, Kiyoshi Fukuhara, Naoki Miyata

Bioorganic & medicinal chemistry letters　Vol. 21　No. 7　p. 2000-2　2011/04/01　Research paper (scientific journal)

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Shusaku Uchida, Kumiko Hara, Ayumi Kobayashi, Koji Otsuki, Hirotaka Yamagata, Teruyuki Hobara, Takayoshi Suzuki, Naoki Miyata, Yoshifumi Watanabe

NEURON　Vol. 69　No. 2　p. 359-372　2011/01　Research paper (scientific journal)

Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells

Mamiko Ikeda, Hidehiko Nakagawa, Shizuka Ban, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

FREE RADICAL BIOLOGY AND MEDICINE　Vol. 49　No. 11　p. 1792-1797　2010/12　Research paper (scientific journal)

Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation

Qi Sun, Akira Hirasawa, Takafumi Hara, Ikuo Kimura, Tetsuya Adachi, Takeo Awaji, Masaji Ishiguro, Takayoshi Suzuki, Naoki Miyata, Gozoh Tsujimoto

MOLECULAR PHARMACOLOGY　Vol. 78　No. 5　p. 804-810　2010/11　Research paper (scientific journal)

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors

Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Kato, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 53　No. 15　p. 5629-5638　2010/08/12　Research paper (scientific journal)

NO donors with 2,6-dimethylnitrobenzene moiety working with two-photon excitation

Kazuhiro Hishikawa, Hidehiko Nakagawa, Taeko Horinouchi, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　Vol. 22　p. S47-S47　2010/06

Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells

Hiroki Tsumoto, Syo Kawahara, Yuki Fujisawa, Takayoshi Suzuki, Hidehiko Nakagawa, Kohfuku Kohda, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 20　No. 6　p. 1948-1952　2010/03　Research paper (scientific journal)

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

Takayoshi Suzuki, Rikako Tanaka, Shohei Hamada, Hidehiko Nakagawa, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 20　No. 3　p. 1124-1127　2010/02　Research paper (scientific journal)

Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation.

Kazuhiro Hishikawa, Hidehiko Nakagawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

Bioorganic & medicinal chemistry letters　Vol. 20　No. 1　p. 302-5　2010/01/01　Research paper (scientific journal)

An Unexpected Example of Protein-Templated Click Chemistry

Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn, Naoki Miyata

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 49　No. 38　p. 6817-6820　2010　Research paper (scientific journal)

Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity

Kazuya Matsuo, Hidehiko Nakagawa, Yusuke Adachi, Eri Kameda, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

CHEMICAL COMMUNICATIONS　Vol. 46　No. 21　p. 3788-3790　2010　Research paper (scientific journal)

Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure

Kiminori Ohta, Takumi Ogawa, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 17　No. 23　p. 7958-7963　2009/12　Research paper (scientific journal)

Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors

Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 131　No. 48　p. 17536-17537　2009/12　Research paper (scientific journal)

Identification of Rat Prostatic Secreted Proteins Using Mass Spectrometric Analysis and Androgen-Dependent mRNA Expression

Nariaki Fujimoto, Tomoharu Suzuki, Shigeru Ohta, Shigeyuki Kitamura

JOURNAL OF ANDROLOGY　Vol. 30　No. 6　p. 669-678　2009/11　Research paper (scientific journal)

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine

Takayoshi Suzuki, Tomomi Asaba, Erika Imai, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 19　No. 19　p. 5670-5672　2009/10　Research paper (scientific journal)

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

Takayoshi Suzuki, Keiko Imai, Erika Imai, Shinsuke Iida, Ryuzo Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 17　No. 16　p. 5900-5905　2009/08　Research paper (scientific journal)

Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation.

Kazuhiro Hishikawa, Hidehiko Nakagawa, Toshiaki Furuta, Kiyoshi Fukuhara, Hiroki Tsumoto, Takayoshi Suzuki, Naoki Miyata

Journal of the American Chemical Society　Vol. 131　No. 22　p. 7488-9　2009/06/10　Research paper (scientific journal)

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors

Shohei Hamada, Tae Dong Kim, Takayoshi Suzuki, Yukihiro Itoh, Hiroki Tsumoto, Hidehiko Nakagawa, Ralf Janknecht, Naoki Miyata

Bioorganic and Medicinal Chemistry Letters　Vol. 19　No. 10　p. 2852-2855　2009/05/15　Research paper (scientific journal)

Inhibition of Human Sirtuins by in Situ Generation of an Acetylated Lysine-ADP-Ribose Conjugate

Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 131　No. 20　p. 6989-6996　2009/05　Research paper (scientific journal)

Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors

Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 52　No. 9　p. 2909-2922　2009/05　Research paper (scientific journal)

Synthesis and biological evaluation of p-carborane bisphenols and their derivatives: Structure-activity relationship for estrogenic activity

Takumi Ogawa, Kiminori Ohta, Toru Iijima, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 17　No. 3　p. 1109-1117　2009/02　Research paper (scientific journal)

Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists

Takayoshi Suzuki, Sou Ichi Igari, Akira Hirasawa, Mie Hata, Masaji Ishiguro, Hiroki Fujieda, Yukihiro Itoh, Tatsuya Hirano, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Gozoh Tsujimoto, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 51　No. 23　p. 7640-7644　2008/12/11　Research paper (scientific journal)

Microtubule Acetylation Through HDAC6 Inhibition Results in Increased Transfection Efficiency

Erin E. Vaughan, R. Christopher Geiger, Aaron M. Miller, Phoebe L. Loh-Marley, Takayoshi Suzuki, Naoki Miyata, David A. Dean

MOLECULAR THERAPY　Vol. 16　No. 11　p. 1841-1847　2008/11　Research paper (scientific journal)

Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring

Kiminori Ohta, Tokuhito Goto, Shinya Fijii, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 17　p. 8022-8028　2008/09　Research paper (scientific journal)

Isoform-selective histone deacetylase inhibitors

Yukihiro Itoh, Takayoshi Suzuki, Naoki Miyata

Current Pharmaceutical Design　Vol. 14　No. 6　p. 529-544　2008/02

Preparation C-60-based active esters and coupling of C-60 moiety to amines or alcohols

Hiroki Tsumoto, Katsumasa Takahashi, Takayoshi Suzuki, Hidehiko Nakagawa, Kohfuku Kohda, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 18　No. 2　p. 657-660　2008/01　Research paper (scientific journal)

Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction

Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki, Naoki Miyata

CHEMICAL COMMUNICATIONS　No. 41　p. 5149-5151　2008　Research paper (scientific journal)

Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors

Yukihiro Itoh, Takayoshi Suzuki, Akiyasu Kouketsu, Nobuaki Suzuki, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 50　No. 22　p. 5425-5438　2007/11/01　Research paper (scientific journal)

Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells

T. Sanda, T. Okamoto, Y. Uchida, H. Nakagawa, S. Iida, S. Kayukawa, T. Suzuki, T. Oshizawa, T. Suzuki, N. Miyata, R. Ueda

LEUKEMIA　Vol. 21　No. 11　p. 2344-2353　2007/11　Research paper (scientific journal)

New series of antiprion compounds: Pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation

Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Takayoshi Suzuki, Naoki Miyata

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 50　No. 21　p. 5053-5056　2007/10

Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPAR delta-selective agonists

Hiroki Fujieda, Shinya Usui, Takayoshi Suzuki, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 17　No. 15　p. 4351-4357　2007/08　Research paper (scientific journal)

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors

Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa, Naoki Miyata

Bioorganic and Medicinal Chemistry Letters　Vol. 17　No. 15　p. 4208-4212　2007/08/01　Research paper (scientific journal)

Synthesis and evaluation of 2-nonylaminopyridine derivatives as PPAR ligands

Shinya Usui, Hiroki Fujieda, Takayoshi Suzuki, Naoaki Yoshida, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Naoki Miyata

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 55　No. 7　p. 1053-1059　2007/07　Research paper (scientific journal)

Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria

Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 17　No. 7　p. 2055-2058　2007/04　Research paper (scientific journal)

Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor

Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa, Naoki Miyata

Bioorganic and Medicinal Chemistry Letters　Vol. 17　No. 6　p. 1558-1561　2007/03/15　Research paper (scientific journal)

Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane

Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 17　No. 5　p. 1451-1454　2007/03　Research paper (scientific journal)

Quantitative determination of lobe specificity of mRNA expression of androgen-dependent genes in the rat prostate gland

Tomoharu Suzuki, Nariaki Fujimoto, Shigeyuki Kitamura, Shigeru Ohta

ENDOCRINE JOURNAL　Vol. 54　No. 1　p. 123-132　2007/02　Research paper (scientific journal)

Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base

Hidehiko Nakagawa, Ryo Ohyama, Ayako Kimata, Takayoshi Suzuki, Naoki Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 16　No. 23　p. 5939-5942　2006/12　Research paper (scientific journal)

2-anilinobenzamides as SIRT inhibitors

Takayoshi Suzuki, Keiko Imai, Hidehiko Nakagawa, Naoki Miyata

CHEMMEDCHEM　Vol. 1　No. 10　p. 1059-+　2006/10　Research paper (scientific journal)

Identification of prostatic-secreted proteins in mice by mass spectrometric analysis and evaluation of lobe-specific and androgen-dependent mRNA expression

Nariaki Fujimoto, Yukimi Akimoto, Tomoharu Suzuki, Shigeyuki Kitamura, Shigeru Ohta

JOURNAL OF ENDOCRINOLOGY　Vol. 190　No. 3　p. 793-803　2006/09　Research paper (scientific journal)

Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate

Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata

Journal of Medicinal Chemistry　Vol. 49　No. 16　p. 4809-4812　2006/08/10　Research paper (scientific journal)

m-carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators

Takumi Ogawa, Kiminori Ohta, Tomohiro Yoshimi, Hiroto Yamazaki, Tomoharu Suzuki, Shigeru Ohta, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 16　No. 15　p. 3943-3946　2006/08　Research paper (scientific journal)

P-442 DISCOVERY OF NOVEL PPARα LIGANDS BY THE MINOR STRUCTURAL MODIFICATIONS OF A PPARγ LIGAND

Fujieda Hiroki, Usui Shinya, Suzuki Takayoshi, Yoshida Naoaki, Nakagawa Hidehiko, Miyata Naoki

International Symposium on the Chemistry of Natural Products　Vol. 2006　p. "P-442"　2006/07/23

P-440 DISCOVERY OF NOVEL HISTONE DEACETYLASE 6 SELECTIVE INHIBITORS

Suzuki Takayoshi, Kouketsu Akiyasu, Itoh Yukihiro, Hisakawa Shinya, Nakagawa Hidehiko, Miyata Naoki

International Symposium on the Chemistry of Natural Products　Vol. 2006　p. "P-440"　2006/07/23

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109

Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida, Satoru Noji, Shinji Yata, Izuru Ando, Masakazu Komatsu, Satoru Ikeda, Hiromasa Hashimoto

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 49　No. 15　p. 4721-4736　2006/07　Research paper (scientific journal)

Identification of novel PPAR alpha ligands by the structural modification of a PPAR gamma ligand

S Usui, H Fujieda, T Suzuki, N Yoshida, H Nakagawa, N Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 16　No. 12　p. 3249-3254　2006/06　Research paper (scientific journal)

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

T Ishida, T Suzuki, S Hirashima, K Mizutani, A Yoshida, Ando, I, S Ikeda, T Adachi, H Hashimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 16　No. 7　p. 1859-1863　2006/04　Research paper (scientific journal)

Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

T Goto, K Ohta, T Suzuki, S Ohta, Y Endo

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 13　No. 23　p. 6414-6424　2005/12　Research paper (scientific journal)

Photoinduced nitric oxide release from nitrobenzene derivatives.

Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, Naoki Miyata

Journal of the American Chemical Society　Vol. 127　No. 33　p. 11720-6　2005/08/24　Research paper (scientific journal)

Potent androgen antagonists based on carborane as a hydrophobic core structure

S Fujii, T Goto, K Ohta, Y Hashimoto, T Suzuki, S Ohta, Y Endo

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 48　No. 14　p. 4654-4662　2005/07　Research paper (scientific journal)

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

T Suzuki, A Matsuura, A Kouketsu, S Hisakawa, H Nakagawa, N Miyata

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 13　No. 13　p. 4332-4342　2005/07　Research paper (scientific journal)

Potent estrogen receptor ligands based on bisphenols with a globular hydrophobic core

Y Endo, T Yoshimi, K Ohta, T Suzuki, S Ohta

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 48　No. 12　p. 3941-3944　2005/06　Research paper (scientific journal)

Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds

S Kitamura, T Suzuki, S Sanoh, R Kohta, N Jinno, K Sugihara, S Yoshihara, N Fujimoto, H Watanabe, S Ohta

TOXICOLOGICAL SCIENCES　Vol. 84　No. 2　p. 249-259　2005/04　Research paper (scientific journal)

Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture

S Kitamura, N Jinno, T Suzuki, K Sugihara, S Ohta, H Kuroki, N Fujimoto

TOXICOLOGY　Vol. 208　No. 3　p. 377-387　2005/03　Research paper (scientific journal)

Design, synthesis, and biological activity of novel PPAR gamma ligands based on rosiglitazone and 15d-PGJ(2)

S Usui, T Suzuki, Y Hattori, K Etoh, H Fujieda, M Nishizuka, M Imagawa, H Nakagawa, K Kohda, N Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 15　No. 6　p. 1547-1551　2005/03　Research paper (scientific journal)

Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis

S Kitamura, T Kato, M Iida, N Jinno, T Suzuki, S Ohta, N Fujimoto, H Hanada, K Kashiwagi, A Kashiwagi

LIFE SCIENCES　Vol. 76　No. 14　p. 1589-1601　2005/02　Research paper (scientific journal)

Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens

T Suzuki, S Kitamura, R Khota, K Sugihara, N Fujimoto, S Ohta

TOXICOLOGY AND APPLIED PHARMACOLOGY　Vol. 203　No. 1　p. 9-17　2005/02　Research paper (scientific journal)

Novel inhibitors of human histone deacetylases: Design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SARA-based non-hydroxamates

T Suzuki, Y Nagano, A Kouketsu, A Matsuura, S Maruyama, M Kurotaki, H Nakagawa, N Miyata

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 48　No. 4　p. 1019-1032　2005/02　Research paper (scientific journal)

A new class of androgen receptor antagonists bearing carborane in place of a steroidal skeleton

S Fujii, Y Hashimoto, T Suzuki, S Ohta, Y Endo

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 15　No. 1　p. 227-230　2005/01　Research paper (scientific journal)

Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design

T Suzuki, A Matsuura, A Kouketsu, H Nakagawa, N Miyata

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 15　No. 2　p. 331-335　2005/01　Research paper (scientific journal)

Thiol-based SAHA analogues as potent histone deacetylase inhibitors

Takayoshi Suzuki, Akiyasu Kouketsu, Azusa Matsuura, Arihiro Kohara, Shin-Ichi Ninomiya, Kohfuku Kohda, Naoki Miyata

Bioorganic and Medicinal Chemistry Letters　Vol. 14　No. 12　p. 3313-3317　2004/06/21　Research paper (scientific journal)

Novel histone deacetylase inhibitors: Design, synthesis, enzyme inhibition, and binding mode study of SAHA-Based non-hydroxamates

Takayoshi Suzuki, Yuki Nagano, Azusa Matsuura, Arihiro Kohara, Shin-Ichi Ninomiya, Kohfuku Kohda, Naoki Miyata

Bioorganic and Medicinal Chemistry Letters　Vol. 13　No. 24　p. 4321-4326　2003/12/15　Research paper (scientific journal)

Superacid-catalyzed electrocyclization of diphenylmethyl cations to fluorenes. Kinetic and theoretical revisit supporting the involvement of ethylene dications

T Ohwada, T Suzuki, K Shudo

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 120　No. 19　p. 4629-4637　1998/05　Research paper (scientific journal)

Superacid-catalyzed electrocyclization of 1-phenyl-2-propen-1-ones to 1-indanones. Kinetic and theoretical studies of electrocyclization of oxonium-carbenium dications

T Suzuki, T Ohwada, K Shudo

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 119　No. 29　p. 6774-6780　1997/07　Research paper (scientific journal)

Structures and reactivities of ethylene dication electrophiles

T Ohwada, T Yamazaki, T Suzuki, S Saito, K Shudo

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 118　No. 26　p. 6220-6224　1996/07　Research paper (scientific journal)