顔写真

PHOTO

LIU LI
LIU LI
LIU LI
LIU LI
Institutional repository
Graduate School of Engineering, Specially Appointed Professor (Full Time)
Institutional repository

Research Areas 3

  1. Life sciences / Biomedical engineering /

  2. Life sciences / Biomaterials /

  3. Life sciences / Cardiovascular surgery /

Papers 70

  1. Four cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant

    Takuya Sumida, Shou Ogawa, Shuichiro Higo, Yuki Kuramoto, Ryo Eto, Yoshihiko Ikeda, Congcong Sun, Junjun Li, Li Liu, Tomoka Tabata, Yoshihiro Asano, Mikio Shiba, Yasuhiro Akazawa, Daisuke Nakamura, Takafumi Oka, Tomohito Ohtani, Yasushi Sakata

    Human Genome Variation　Vol. 11　No. 1　2024/12/20　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  2. Label-Free Raman Spectroscopy for Assessing Purity and Maturation of hiPSC-Derived Cardiac Tissue

    Junjun Li, Menglu Li, Yasunori Nawa, Yuting Liu, Kazuki Bando, Ying Hua, Lifu Sun, Satoshi Fujita, Yoshiki Sawa, Katsumasa Fujita, Li Liu

    Analytical Chemistry　Vol. 96　No. 39　p. 15765-15772　2024/09/18　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  3. Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction

    Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Lifu Sun, Akima Harada, Ying Hua, Nagako Sougawa, Akiko Tabata, Li Liu, Shigeru Miyagawa

    Bioactive Materials　Vol. 37　p. 533-548　2024/07　Research paper (scientific journal)

    Publisher: Elsevier BV

  4. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment

    Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, Shuichiro Higo, Nagako Sougawa, Maki Takeda, Takuji Kawamura, Ryohei Matsuura, Daisuke Okuzaki, Toshihiko Toyofuku, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

    iScience　Vol. 27　No. 2　p. 108992-108992　2024/02　Research paper (scientific journal)

    Publisher: Elsevier BV

  5. Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts.

    Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Akiko Tabata, Lifu Sun, Li Liu, Shigeru Miyagawa

    Stem cell research & therapy　Vol. 14　No. 1　p. 380-380　2023/12/20　Research paper (scientific journal)

  6. Effect of morphological change on the maturation of human induced pluripotent stem cell-derived cardiac tissue in rotating flow culture

    Akihiro Hashida, Taro Nakazato, Toshimasa Uemura, Li Liu, Shigeru Miyagawa, Yoshiki Sawa, Masahiro Kino-oka

    Regenerative Therapy　Vol. 24　p. 479-488　2023/12　Research paper (scientific journal)

  7. Developing Thick Cardiac Tissue with a Multilayer Fiber Sheet for Treating Myocardial Infarction

    Junjun Li, Xiang Qu, Li Liu, Lingjun Li, Ying Hua, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Nagako Sougawa, Emiko Ito, Noriko Mochizuki-Oda, Akima Harada, Takuji Kawamura, Ryohei Matsuura, Yingzhe Wang, Keisuke Morishima, Shigeru Miyagawa, Yoshiki Sawa

    Advanced Fiber Materials　2023/07/31　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  8. ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.

    Xiang Qu, Junjun Li, Li Liu, Jingbo Zhang, Ying Hua, Kota Suzuki, Akima Harada, Masako Ishida, Noriko Yoshida, Daisuke Okuzaki, Yoshiki Sakai, Yoshiki Sawa, Shigeru Miyagawa

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation　Vol. 42　No. 6　p. 716-729　2023/06　Research paper (scientific journal)

  9. Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

    Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun-ichi Haruta, Seiji Takashima

    Circulation　Vol. 147　No. 25　p. 1902-1918　2023/05/02　Research paper (scientific journal)

    Publisher: Ovid Technologies (Wolters Kluwer Health)

  10. Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier

    Satoshi Kameda, Shuichiro Higo, Mikio Shiba, Takumi Kondo, Junjun Li, Li Liu, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Yuki Kuramoto, Hideki Yasutake, Jong-Kook Lee, Seiji Takashima, Yoshihiko Ikeda, Shungo Hikoso, Shigeru Miyagawa, Yasushi Sakata

    JACC: Basic to Translational Science　2023/02　Research paper (scientific journal)

    Publisher: Elsevier BV

  11. Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives

    Junjun Li, Li Liu, Jingbo Zhang, Xiang Qu, Takuji Kawamura, Shigeru Miyagawa, Yoshiki Sawa

    Bioengineering　Vol. 9　No. 11　p. 605-605　2022/10/22　Research paper (scientific journal)

    Publisher: MDPI AG

  12. Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing

    Jingbo Zhang, Xiang Qu, Junjun Li, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

    International Journal of Molecular Sciences　Vol. 23　No. 20　p. 12697-12697　2022/10/21　Research paper (scientific journal)

    Publisher: MDPI AG

  13. Regenerative Effect of Umbilical Cord-Derived Mesenchymal Stromal Cells in a Rat Model of Established Limb Ischemia

    Keisuke Miyake, Nobuyoshi Azuma, Chugo Rinoie, Shusaku Maeda, Akima Harada, Liu Li, Itsunari Minami, Shigeru Miyagawa, Yoshiki Sawa

    Circulation Journal　2022/09/27　Research paper (scientific journal)

    Publisher: Japanese Circulation Society

  14. Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy

    Takumi Kondo, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Satoki Nakamura, Maki Takeda, Emiko Ito, Junjun Li, Li Liu, Yuki Kuramoto, Jong-Kook Lee, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

    Circulation: Genomic and Precision Medicine　2022/07/12　Research paper (scientific journal)

    Publisher: Ovid Technologies (Wolters Kluwer Health)

  15. Development and evaluation of a novel xeno-free culture medium for human-induced pluripotent stem cells

    Ying Hua, Kenji Yoshimochi, Junjun Li, Kazuhiro Takekita, Motoshi Shimotsuma, Lingjun Li, Xiang Qu, Jingbo Zhang, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

    Stem Cell Research & Therapy　Vol. 13　No. 1　2022/06/03　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  16. Engineered three-dimensional cardiac tissues maturing in a rotating wall vessel bioreactor remodel diseased hearts in rats with myocardial infarction

    Taro Nakazato, Takuji Kawamura, Toshimasa Uemura, Li Liu, Junjun Li, Masao Sasai, Akima Harada, Emiko Ito, Hiroko Iseoka, Koichi Toda, Yoshiki Sawa, Shigeru Miyagawa

    Stem Cell Reports　Vol. 17　No. 5　p. 1170-1182　2022/05　Research paper (scientific journal)

    Publisher: Elsevier BV

  17. Nanocasting of fibrous morphology on a substrate for long-term propagation of human induced pluripotent stem cells.

    Sisi Li, Momoko Yoshioka, Junjun Li, Li Liu, Shixin Ye, Ken-Ichiro Kamei, Yong Chen

    Biomedical materials (Bristol, England)　Vol. 17　No. 2　2022/02/18　Research paper (scientific journal)

  18. Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes.

    Hiroyuki Inoue, Satoki Nakamura, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Takumi Kondo, Satoshi Kameda, Tomoka Tabata, Shota Okuno, Yoshihiko Ikeda, Junjun Li, Li Liu, Satoru Yamazaki, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

    Stem cell reports　Vol. 17　No. 2　p. 337-351　2022/02/08　Research paper (scientific journal)

  19. iPS 由来心筋組織構築技術の現状

    劉莉

    人工臓器　Vol. 51　No. 3　2022　Research paper (bulletin of university, research institution)

  20. Therapeutic efficacy of large aligned cardiac tissue derived from induced pluripotent stem cell in a porcine ischemic cardiomyopathy model.

    Kota Suzuki, Shigeru Miyagawa, Li Liu, Takuji Kawamura, Junjun Li, Xiang Qu, Akima Harada, Koichi Toda, Daisuke Yoshioka, Satoshi Kainuma, Ai Kawamura, Yoshiki Sawa

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation　Vol. 40　No. 8　p. 767-777　2021/05/08　Research paper (scientific journal)

  21. Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

    Mikio Shiba, Shuichiro Higo, Takumi Kondo, Junjun Li, Li Liu, Yoshihiko Ikeda, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Satoki Nakamura, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

    Human Molecular Genetics　2021/05/05　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  22. iPS細胞由来心筋成熟促進技術の開発及び創薬への応用

    劉莉

    生産と技術　Vol. 73　No. 2　p. 101-104　2021　Research paper (scientific journal)

  23. Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium.

    Junjun Li, Li Liu, Itsunari Minami, Shigeru Miyagawa, Yoshiki Sawa

    Methods in molecular biology (Clifton, N.J.)　Vol. 2320　p. 65-73　2021　Research paper (scientific journal)

  24. Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells

    Lu Zhang, Junjun Li, Li Liu, Chao Tang

    Scientific Reports　Vol. 10　No. 1　2020/12/01　Research paper (scientific journal)

    Publisher: Nature Research

  25. hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery.

    Junjun Li, Ying Hua, Shigeru Miyagawa, Jingbo Zhang, Lingjun Li, Li Liu, Yoshiki Sawa

    International journal of molecular sciences　Vol. 21　No. 23　2020/11/24　Research paper (scientific journal)

  26. Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring.

    Junjun Li, Lu Zhang, Leqian Yu, Itsunari Minami, Shigeru Miyagawa, Marcel Hörning, Ji Dong, Jing Qiao, Xiang Qu, Ying Hua, Nanae Fujimoto, Yuji Shiba, Yang Zhao, Fuchou Tang, Yong Chen, Yoshiki Sawa, Chao Tang, Li Liu

    Communications biology　Vol. 3　No. 1　p. 122-122　2020/03/13　Research paper (scientific journal)

  27. Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation.

    Leqian Yu, Junjun Li, Itsunari Minami, Xiang Qu, Shigeru Miyagawa, Nanae Fujimoto, Kouichi Hasegawa, Yong Chen, Yoshiki Sawa, Hidetoshi Kotera, Li Liu

    Advanced healthcare materials　Vol. 8　No. 13　2019/07　Research paper (scientific journal)

  28. Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

    Yasumasa Mashimo, Momoko Yoshioka, Yumie Tokunaga, Christopher Fockenberg, Shiho Terada, Yoshie Koyama, Teiko Shibata-Seki, Koki Yoshimoto, Risako Sakai, Hayase Hakariya, Li Liu, Toshihiro Akaike, Eiry Kobatake, Siew-Eng How, Motonari Uesugi, Yong Chen, Ken-ichiro Kamei

    Journal of Visualized Experiments　No. 139　2018/09/07　Research paper (scientific journal)

    Publisher: MyJove Corporation

  29. Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells.

    Kaori Yamauchi, Junjun Li, Kumi Morikawa, Li Liu, Yasuaki Shirayoshi, Norio Nakatsuji, David A Elliott, Ichiro Hisatome, Hirofumi Suemori

    Biochemical and biophysical research communications　Vol. 495　No. 1　p. 1278-1284　2018/01/01　Research paper (scientific journal)

  30. Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

    Leqian Yu, Leqian Yu, Junjun Li, Junjun Li, Jiayin Hong, Yasuhiro Takashima, Nanae Fujimoto, Nanae Fujimoto, Minako Nakajima, Minako Nakajima, Akihisa Yamamoto, Akihisa Yamamoto, Xiaofeng Dong, Yujiao Dang, Yu Hou, Wei Yang, Itsunari Minami, Keisuke Okita, Motomu Tanaka, Motomu Tanaka, Motomu Tanaka, Chunxiong Luo, Fuchou Tang, Yong Chen, Yong Chen, Yong Chen, Chao Tang, Hidetoshi Kotera, Hidetoshi Kotera, Hidetoshi Kotera, Li Liu

    Stem Cell Reports　Vol. 11　No. 1　p. 142-156　2018/01/01　Research paper (scientific journal)

  31. Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium

    Junjun Li, Itsunari Minami, Motoko Shiozaki, Leqian Yu, Shin Yajima, Shigeru Miyagawa, Yuji Shiba, Nobuhiro Morone, Satsuki Fukushima, Momoko Yoshioka, Sisi Li, Jing Qiao, Xin Li, Lin Wang, Hidetoshi Kotera, Norio Nakatsuji, Yoshiki Sawa, Yong Chen, Li Liu

    STEM CELL REPORTS　Vol. 9　No. 5　p. 1546-1559　2017/11　Research paper (scientific journal)

  32. Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments

    Ken-ichiro Kamei, Yasumasa Mashimo, Momoko Yoshioka, Yumie Tokunaga, Christopher Fockenberg, Shiho Terada, Yoshie Koyama, Minako Nakajima, Teiko Shibata-Seki, Li Liu, Toshihiro Akaike, Eiry Kobatake, Siew-Eng How, Motonari Uesugi, Yong Chen

    SMALL　Vol. 13　No. 18　2017/05　Research paper (scientific journal)

  33. Nano-on-micro fibrous extracellular matrices for scalable expansion of human ES/iPS cells

    Li Liu, Ken-ichiro Kamei, Momoko Yoshioka, Minako Nakajima, Junjun Li, Nanae Fujimoto, Shiho Terada, Yumie Tokunaga, Yoshie Koyama, Hideki Sato, Kouichi Hasegawa, Norio Nakatsuji, Yong Chen

    BIOMATERIALS　Vol. 124　p. 47-54　2017/04　Research paper (scientific journal)

  34. Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells

    J. Li, F. Zhang, L. Yu, N. Fujimoto, M. Yoshioka, X. Li, J. Shi, H. Kotera, L. Liu, Y. Chen

    JOURNAL OF MATERIALS CHEMISTRY B　Vol. 5　No. 2　p. 236-244　2017/01　Research paper (scientific journal)

  35. On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure

    Xin Li, Leqian Yu, Junjun Li, Itsunari Minami, Minako Nakajima, Yuichiro Noda, Hidetoshi Kotera, Li Liu, Yong Chen

    BIOFABRICATION　Vol. 8　No. 3　2016/09　Research paper (scientific journal)

  36. Extracellular recordings of patterned human pluripotent stem cell-derived cardiomyocytes on aligned fibers

    Junjun Li, Itsunari Minami, Leqian Yu, Kiyotaka Tsuji, Minako Nakajima, Jing Qiao, Masato Suzuki, Ken Shimono, Norio Nakatsuji, Hitetoshi Kotera, Li Liu, Yong Chen

    Stem Cells International　Vol. 2016　p. 1-9　2016　Research paper (scientific journal)

  37. Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers

    Yadong Tang, Li Liu, Junjun Li, Leqian Yu, Li Wang, Jian Shi, Yong Chen

    NANOSCALE　Vol. 8　No. 30　p. 14530-14540　2016　Research paper (scientific journal)

  38. Effective motor neuron differentiation of hiPSCs on a patch made of crosslinked monolayer gelatin nanofibers

    Yadong Tang, Li Liu, Junjun Li, Leqian Yu, Francesco Paolo Ulloa Severino, Li Wang, Jian Shi, Xiaolong Tu, Vincent Torre, Yong Chen

    JOURNAL OF MATERIALS CHEMISTRY B　Vol. 4　No. 19　p. 3305-3312　2016　Research paper (scientific journal)

  39. Single-cell cloning and expansion of human induced pluripotent stem cells by a microfluidic culture device

    Taku Matsumura, Kazuya Tatsumi, Yuichiro Noda, Naoyuki Nakanishi, Atsuhito Okonogi, Kunio Hirano, Liu Li, Takashi Osumi, Takashi Tada, Hidetoshi Kotera

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 453　No. 1　p. 131-137　2014/10　Research paper (scientific journal)

  40. Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells

    Li Liu, Momoko Yoshioka, Minako Nakajima, Arata Ogasawara, Jun Liu, Kouichi Hasegawa, Sisi Li, Jianli Zou, Norio Nakatsuji, Ken-ichiro Kamei, Yong Chen

    BIOMATERIALS　Vol. 35　No. 24　p. 6259-6267　2014/08　Research paper (scientific journal)

  41. Multi-electrode monitoring of guided excitation in patterned cardiomyocytes

    L. Wang, L. Liu, X. Li, N. Magome, K. Agladze, Y. Chen

    MICROELECTRONIC ENGINEERING　Vol. 111　p. 267-271　2013/11　Research paper (scientific journal)

  42. Fabrication of gelatin nanopatterns for cell culture studies

    S. S. Li, J. Shi, L. Liu, J. J. Li, L. M. Jiang, C. X. Luo, K. Kamei, Y. Chen

    MICROELECTRONIC ENGINEERING　Vol. 110　p. 70-74　2013/10　Research paper (scientific journal)

  43. Influence of patterned topographic features on the formation of cardiac cell clusters and their rhythmic activities

    L. Wang, L. Liu, N. Magome, K. Agladze, Y. Chen

    Biofabrication　Vol. 5　No. 3　2013/09　Research paper (scientific journal)

  44. Chemically-defined scaffolds created with electrospun synthetic nanofibers to maintain mouse embryonic stem cell culture under feeder-free conditions

    Li Liu, Qinghua Yuan, Jian Shi, Xin Li, Dongju Jung, Li Wang, Kaori Yamauchi, Norio Nakatsuji, Ken-ichiro Kamei, Yong Chen

    BIOTECHNOLOGY LETTERS　Vol. 34　No. 10　p. 1951-1957　2012/10　Research paper (scientific journal)

  45. Incorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells

    Dongju Jung, Itsunari Minami, Sahishnu Patel, Jonghwan Lee, Bin Jiang, Qinghua Yuan, Liu Li, Sachiko Kobayashi, Yong Chen, Ki-Bum Lee, Norio Nakatsuji

    JOURNAL OF NANOBIOTECHNOLOGY　Vol. 10　2012/06　Research paper (scientific journal)

  46. Microfluidic devices with disposable enzyme electrode for electrochemical monitoring of glucose concentrations

    Xin Li, Fan Zhang, Jian Shi, Li Wang, Jing-Hua Tian, Xiong-Tu Zhou, Lian-Mei Jiang, Li Liu, Zhen-Jie Zhao, Pin-Gang He, Yong Chen

    ELECTROPHORESIS　Vol. 32　No. 22　p. 3201-3206　2011/11　Research paper (scientific journal)

  47. Differentiating stem cells on patterned substrates for neural network formation

    Chunxiong Luo, Chunxiong Luo, Li Liu, Xiaofang Ni, Xiaofang Ni, Li Wang, Li Wang, Shinichiro M. Nomura, Qi Ouyang, Yong Chen, Yong Chen, Yong Chen

    Microelectronic Engineering　Vol. 88　p. 1707-1710　2011/08/01

  48. Cell culture on AAO nanoporous substrates with and without geometry constrains

    J. Hu, J. H. Tian, J. Shi, F. Zhang, D. L. He, L. Liu, D. J. Jung, J. B. Bai, Y. Chen

    MICROELECTRONIC ENGINEERING　Vol. 88　No. 8　p. 1714-1717　2011/08　Research paper (scientific journal)

  49. Fabrication of polymer fiber scaffolds by centrifugal spinning for cell culture studies

    Li Wang, Jian Shi, Li Liu, Emilie Secret, Yong Chen

    MICROELECTRONIC ENGINEERING　Vol. 88　No. 8　p. 1718-1721　2011/08　Research paper (scientific journal)

  50. Investigation of cell culture in microfluidic devices with different bi-layer substrates

    Jian Shi, Li Liu, Yong Chen

    MICROELECTRONIC ENGINEERING　Vol. 88　No. 8　p. 1693-1697　2011/08　Research paper (scientific journal)

  51. Electrospun nanofibers as a tool for architecture control in engineered cardiac tissue

    Yuliya Orlova, Nobuyuki Magome, Li Liu, Yong Chen, Konstantin Agladze

    BIOMATERIALS　Vol. 32　No. 24　p. 5615-5624　2011/08　Research paper (scientific journal)

  52. Integrated and diffusion-based micro-injectors for open access cell assays

    Xin Li, Li Liu, Li Wang, Ken-ichiro Kamei, Qinghua Yuan, Fan Zhang, Jian Shi, Akihiro Kusumi, Min Xie, Zhenjie Zhao, Yong Chen

    LAB ON A CHIP　Vol. 11　No. 15　p. 2612-2617　2011　Research paper (scientific journal)

  53. A micro-channel-well system for culture and differentiation of embryonic stem cells on different types of substrate

    Li Liu, Chunxiong Luo, Xiaofeng Ni, Li Wang, Kaori Yamauchi, Shinichi M. Nomura, Norio Nakatsuji, Yong Chen

    BIOMEDICAL MICRODEVICES　Vol. 12　No. 3　p. 505-511　2010/06　Research paper (scientific journal)

  54. High resolution and hybrid patterning for single cell attachment

    J. Hu, J. Shi, F. Zhang, L. Lei, X. Li, L. Wang, L. Liu, Y. Chen

    MICROELECTRONIC ENGINEERING　Vol. 87　No. 5-8　p. 726-729　2010/05　Research paper (scientific journal)

  55. Incorporating Protein Gradient into Electrospun Nanofibers As Scaffolds for Tissue Engineering

    Jian Shi, Li Wang, Fan Zhang, Hao Li, Lei Lei, Li Liu, Yong Chen

    ACS APPLIED MATERIALS & INTERFACES　Vol. 2　No. 4　p. 1025-1030　2010/04　Research paper (scientific journal)

  56. Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice

    Takashi Sakai, Li Liu, Xichuan Teng, Naozumi Ishimaru, Rika Mukai-Sakai, Nam Hoang Tran, Sun Mi Kim, Nobuya Sano, Yoshio Hayashi, Ryuji Kaji, Kiyoshi Fukui

    INTERNATIONAL JOURNAL OF CANCER　Vol. 126　No. 5　p. 1079-1094　2010/03　Research paper (scientific journal)

  57. Degassing-Assisted Patterning of Cell Culture Surfaces

    Chunxiong Luo, Xiaofang Ni, Li Liu, Shin-ichiro M. Nomura, Yong Chen

    BIOTECHNOLOGY AND BIOENGINEERING　Vol. 105　No. 4　p. 854-859　2010/03　Research paper (scientific journal)

  58. Cleavage pattern of DNA caused by endonuclease: Theoretical modeling and experimental verification

    Shio Inagaki, Li Liu, Masahiro Takinoue, Kenichi Yoshikawa

    APPLIED PHYSICS LETTERS　Vol. 96　No. 6　2010/02　Research paper (scientific journal)

  59. Growth and attachment of embryonic stem cell colonies on single nanofibers

    L. Liu, J. Shi, Q. H. Yuan, L. Wang, Y. Chen

    Micro and Nanosystems　Vol. 2　No. 4　p. 269-273　2010　Research paper (scientific journal)

    Publisher: Bentham Science Publishers B.V.

  60. Nucling interacts with nuclear factor-kappa B, regulating its cellular distribution

    Li Liu, Takashi Sakai, Nam Hoang Tran, Rika Mukai-Sakai, Ryuji Kaji, Kiyoshi Fukui

    FEBS JOURNAL　Vol. 276　No. 5　p. 1459-1470　2009/03　Research paper (scientific journal)

  61. Nucling interacts with nuclear factor-B, regulating its cellular distribution

    Li Liu, Takashi Sakai, Nam Hoang Tran, Rika Mukai-Sakai, Ryuji Kaji, Kiyoshi Fukui

    The FEBS Journal　Vol. 276　No. 5　p. 1459-1470　2009/03　Research paper (scientific journal)

  62. Giant liposome sorting/collection device: for individual analysis of artificial cell-models

    S.-i. M. NOMURA, L. LIU, Y. CHEN, H. MARUYAMA, F. ARAI

    Int. Symp. Micro-Nanomechatronics & Human Science　2009　Research paper (international conference proceedings)

  63. Nucling regulates nuclear translocation and activation of NF-κB through interaction with NF-kB-p50

    Li Liu, Takashi Sakai, Nam Hoang Tran, Rika Mukai-Sakai, Ryuji Kaji, Kiyoshi Fukui

    FEBS J.　Vol. 276　No. 5　p. 1459-1470　2009　Research paper (scientific journal)

  64. 新規アポトーシス制御分子ヌクリングはNF-κBの制御に関与する

    Tran Hoang Nam, 坂井 隆志, El-Sayed Salah M., 劉 莉, 坂井 利佳, 石丸 直澄, 林 良夫, 梶 龍兒, 福井 清

    生化学　Vol. 80　No. 7　p. 694-694　2008/07

    Publisher: (公社)日本生化学会

  65. ヌクリング欠損は肝クッパー細胞枯渇をもたらし、その結果として肝炎・肝癌発症率を上昇させる

    坂井 隆志, 陳 南, 劉 莉, 勝 錫川, 石丸 直澄, 坂井 利佳, 佐野 暢哉, 梶 龍兒, 林 良夫, 福井 清

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 80回・30回　p. 3T19-6　2007/11

    Publisher: (公社)日本生化学会

  66. 新規アポトーシス制御分子ヌクリングの肝癌発症機構における役割の解明

    坂井 隆志, 劉 莉, 滕 錫川, 石丸 直澄, 坂井 利佳, 佐野 暢哉, 梶 龍兒, 陳 黄南, 福井 清

    生化学　Vol. 79　No. 10　p. 988-988　2007/10

    Publisher: (公社)日本生化学会

  67. Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway

    XC Teng, T Sakai, L Liu, R Sakai, R Kaji, K Fukui

    JOURNAL OF NEUROCHEMISTRY　Vol. 97　No. 4　p. 1126-1135　2006/05　Research paper (scientific journal)

  68. Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis

    T Sakai, L Liu, XC Teng, R Mukai-Sakai, H Shimada, R Kaji, T Mitani, M Matsumoto, K Toida, K Ishimura, Y Shishido, TW Mak, K Fukui

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 39　p. 41131-41140　2004/09　Research paper (scientific journal)

  69. Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappa B signalling

    L Liu, T Sakai, N Sano, K Fukui

    BIOCHEMICAL JOURNAL　Vol. 380　p. 31-41　2004/05　Research paper (scientific journal)

  70. Identification of a novel, embryonal carcinoma cell-associated molecule, Nucling, that is up-regulated during cardiac muscle differentiation

    T Sakai, L Liu, Y Shishido, K Fukui

    JOURNAL OF BIOCHEMISTRY　Vol. 133　No. 4　p. 429-436　2003/04　Research paper (scientific journal)

Misc. 31

  1. 回転浮遊培養によるヒトiPS細胞由来心筋組織の成熟化メカニズムの解明

    植村寿公, 植村寿公, 橋田礼博, 中里太郎, LIU Li, 宮川繁, 澤芳樹, 紀ノ岡正博

    日本再生医療学会総会(Web)　Vol. 23rd　2024

  2. SCAD-MT Cardiomyocyte: Human Pluripotent Stem Cell-Derived Cardiomyocyte Micro-tissues That Show Maturation and Functional Stability Promoted by Using Aligned Nanofibers

    Kazuhiro Aiba, Liu Li, Kensuke Kato, Norio Nakatsuji

    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS　Vol. 88　p. 235-235　2017/11　Research paper, summary (international conference)

  3. Low cell-matrix adhesion microenvironment promote maintain of high-pluripotency state stem cells

    Li Liu

    10 Years of iPSCs Cell Symposium　2016/09　Research paper, summary (international conference)

  4. Engineered anisotropic and 3-demensional hiPS-derived cardiac tissue-like construct for drug assessment and cardiac disease repairing

    Li Liu

    2016/06　Research paper, summary (international conference)

  5. Creating functional anisotropic and 3D tissue-like construct using induced pluripotent stem cell-derived cardiomyocytes

    Li Liu

    CiRA/ISSCR 2016 International Symposia　2016/03　Research paper, summary (international conference)

  6. Controlling Maturation And Function Of Cardiomyocytes Derived From Human Pluripotent Stem Cells Using Aligned Nanofibers

    Li Liu

    ISSCR　2015/06　Research paper, summary (international conference)

  7. Creating "right" microenvironments for controlling stem cell phenotypes

    KAMEI KEN-ICHIRO, MASHIMO YASUMASA, YOSHIOKA MOMOKO, LIU LI, CHEN YONG

    組織培養研究　Vol. 34　No. 1　2015/03/31

  8. Combinatorial screening of gelatin nanofibers as cellular scaffolds to expand hPSCs for long-term period

    Li Liu

    11th International Society for Stem Cell Research (ISSCR) Annual Meeting　2014/06　Research paper, summary (international conference)

  9. High-throughput screening platform of engineered cellular microenvironments for human pluripotent stem cells

    MASHIMO YASUMASA, KAMEI KEN-ICHIRO, FOCKENBERG CHRISTOPHER, LI LIU, NAKAJIMA MINAKO, YOSHIOKA MOMOKO, NAKATSUJI NORIO, CHEN YONG

    日本化学会講演予稿集　Vol. 94th　No. 3　2014/03/12

  10. ナノファイバーを用いたヒト多能性幹細胞培養基材の開発

    亀井謙一郎, 劉莉, 吉岡桃子, 長谷川光一, 中辻憲夫, 陳勇

    再生医療　Vol. 13　2014/01/27

  11. ハイスループット・マイクロ流体デバイスを用いたヒトES/iPS細胞培養用ナノファイバー・スクリーニング

    眞下泰正, FOCKENBERG Chris, 小山芳江, 劉莉, 陳勇, 亀井謙一郎

    再生医療　Vol. 13　2014

  12. Maintain long-term culture of human pluripotent stem cells by gelatin nanofibrous substrate

    劉 莉

    UST-Kyoto Univ. iCeMS International symposium　2013/11　Research paper, summary (international conference)

  13. Artificial extracellular matrix for maintain long-term culture of human iPS/ES cells by gelatin nanofibrous substrate

    劉 莉

    Microfludics And Quantitative Biology　2013/10　Research paper, summary (international conference)

  14. Patterning aligned nanofibers for uniform colony formation of mouse embryonic stem cells and derived neural growth

    Li Liu

    38th International Conference on Micro and Nano Engineering　2012/09　Research paper, summary (international conference)

  15. Phenotypic Modulation of Pluripotent Stem Cells by Microfabrication Materials

    Kenichiro Kamei, Yoshikazu Hirai, Yoshihide Makino, Li Liu, Qinghua Yuan, Osamu Tabata

    The International Society for Stem Cell Research (ISSCR) 10th Annual Meeting　2012/06

  16. Artificial cellular microenvironments using electrospun synthetic nanofibers maintain self-renewal of mouse embryonic stem cells

    Li Liu

    10th International Society for Stem Cell Research (ISSCR) Annual Meeting　2012/06　Research paper, summary (international conference)

  17. Electrospun nanofibers as synthetic cellular environmental cues for feeder- and serum-free culture and pluripotency maintenance of mouse embryonic stem cells

    劉 莉

    Crossing Boundaries: Stem cells, Materials, Mesoscopic Sciences and Beyond　2012/04　Research paper, summary (international conference)

  18. Evaluation of negative photoresists on phenotypes of human induced pluripotent stem cells (hiPSCs)

    K. Kamei, Yoshikazu Hirai, Y. Makino, L. Liu, Q. Yuan, M. Yoshioka, Y. Chen, Osamu Tabata

    The 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems　p. 558-559　2012/03

  19. Application of nanofiber for controlling self-renewal of human pluripotency stem cells

    劉 莉

    11th iCeMS International Symposium　2011/12　Research paper, summary (international conference)

  20. Evaluation of Negative Photoresists for Culturing Mouse and Human Pluripotent Stem Cells

    KAMEI KEN-ICHIRO, HIRAI YOSHIKAZU, MAKINO YOSHIHIDE, LIU LI, YUAN QINGHUA, CHEN YONG, TABATA OSAMU

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)　Vol. 28th　2011/09/26

  21. フォトレジスト基板のマウス・ヒト多能性幹細胞に与える影響の評価

    亀井謙一郎, 平井義和, 牧野圭秀, Li Liu, Qinghua Yuan, Yong Chen, 田畑修

    第28回「センサ・マイクロマシンと応用システム」シンポジウム　p. 89-92　2011/09

  22. MESC and hiPSC proliferation on negative photoresists for microfluidics

    Y. Hirai, K.-I. Kamei, Y. Makino, L. Liu, Q. Yuan, Y. Chen, O. Tabata

    Procedia Engineering　Vol. 25　p. 1233-1236　2011/01

  23. Long-term feeder-free culture of mouse embryonic stem cells on electrospun nanofibers

    劉 莉

    8th iCeMS Interventional Symposium　2010/11　Research paper, summary (international conference)

  24. Microfluidics and nanofiber technologies for cell biology studies

    劉 莉

    5th iCeMS Interventional Symposium　2009/07　Research paper, summary (international conference)

  25. Microfluidics and nanofabrication technologies for advanced cell biology studies

    劉 莉

    4th iCeMS Interventional Symposium　2009/05　Research paper, summary (international conference)

  26. A novel type cationic silica nanoparticles and its potential application in biomedicine

    Li Liu, Toshio Takenaka, Anatoly A. Zinchenko, Ning Chen, Yue Ma, Kenichi Yoshikawa

    2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008　p. 1539-1542　2008　Research paper, summary (international conference)

    Publisher: IEEE Computer Society

  27. Cationic silica nanoparticles are efficiently transferred into mammalian cells

    Liu L, Takenaka T, Zinchenko A.A, Chen N, Inagaki S, Asada H, Kishida T, Mazda O, Murata S, Yoshikawa K

    2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS　p. 281-285　2007

  28. Nucling inhibits nuclear translocation and activation of NF-κB through interaction with NF-κB-p50

    劉 莉

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress　2006/06　Research paper, summary (international conference)

  29. Nucling mediates apotosis by inhibiting expression of galectin-3 through interference with NF-κB signaling

    劉 莉

    77th 日本生化学会　2004/10　Research paper, summary (national, other academic conference)

  30. Antiapoptotic molecule, galectin-3 participates in an apotosis pathway by interacting with Nucling

    劉 莉

    76th 日本生化学会　2003/10　Research paper, summary (national, other academic conference)

  31. To Screen Protein Molecules Interacting with Nucling

    劉 莉

    75th 日本生化学会　2002/10　Research paper, summary (national, other academic conference)

Publications 1

  1. Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium

    Humana, New York, NY

Presentations 15

  1. Human iPSC derived cardiac tissue matured by spontaneous traveling waves for improved drug assessment.

    Li, J, Liu, L, Miyagawa, S, Kawamura, T, Matsuura, R, Hua, Y, Qu, X, Sougawa, N, Sawa, Y

    American Heart Association Scientific Session,

  2. Micro-/Nanofibrous Matrices for pluripotent stem cell and cardiac tissue transplantation

    LIU, Li

    MU-OU joint Symposium　2021/10/11

  3. 機能性iPS細胞由来心筋組織を用いた心不全再生医療法の開発

  4. ナノファイバーを用いたヒトiPS細胞由来心筋組織の構築及び再生医療への応用

    2020

  5. Circulating traveling waves enhance the maturation of hipsc-derived cardiomyocytes in self-organized tissue ring

    Li, J, Liu, L

    the 8th Meeting of the International Federation for Artificial Organs.　2019/11/13

  6. 組織工学技術による新規心筋成熟法の開発

    劉莉

    第18回日本再生医療学会

  7. iPS細胞培養基材及び心筋移植デバイスの開発

    劉莉

    フォトバイオ協議会第6回ワークフョップ　2019/01/17

  8. 再生医療応用するための組織デバイスの開発

    劉莉

    第55回フォトニクス・コロキアム　2019/01/08

  9. ファイバーを用いたiPS細胞培養基材及び心筋組織を構築するためのデバイスの開発

    劉 莉

    iPS細胞ビジネス協議会第29回情報交換会　2018/09/11

  10. iPS細胞由来心筋細胞の誘導とナノファイバーを用いた３次元配向心筋組織の作製

    劉 莉

    第４回細胞凝集研究会　2016/09

  11. 配列・3次元構造を有するヒト多能性幹細胞由来心筋組織片を用いた心毒性評価への応用

    劉 莉

    第１5回日本再生医療学会　2016/03

  12. ナノファイバーを用いた再生医療への応用

    劉 莉

    2015年度日本機械学会年次大会　2015/09

  13. 配列・成熟・組織化したヒト多能性幹細胞由来心筋組織片の開発

    Li Liu

    2015/03

  14. Biomimic cellular microenvironment by using artificial extracellular matrix and microfluidics

    Li Liu

    Lab on chip in Asia, Singapore　2014/11/21

  15. Cationic Silica Nanoparticles are Efficiently Transferred into Mammalian Cells

    劉 莉

    MHS 2007 & Micro-Nano COE　2007/11

Industrial Property Rights 19

  1. 多能性幹細胞の培養方法及びそのための基材

    特許第6024047号

    出願日:2012/06/04

    登録日:2016/10/21

  2. 細胞の凝集体の製造方法、凝集体の集団、細胞の培養方法

    澤 芳樹, 劉 莉, 李 俊君, 伊東 絵望子, 武田 真季

    出願日:2023/12/04

  3. 人工心筋組織、その使用、及びその製造方法

    劉 莉, 李 俊君, 澤 芳樹, 宮川 繁, 武田 真季

    出願日:2023/09/12

  4. 多層重厚組織体、その製造方法及びその用途

    劉 莉, 李 俊君, 澤 芳樹, 宮川 繁, 伊東 絵望子

    出願日:2022/12/26

  5. 細胞培養方法及びその装置

    出願日:2022/03/14

  6. ラマン散乱を用いた心筋細胞の評価方法

    藤田 克昌, 畔堂 一樹, 劉 莉, 李 俊君, 澤 芳樹, 宮川 繁, 名和 靖矩, 藤田 聡史

    出願日:2022/01/17

  7. 心筋細胞層の製造方法、心筋細胞層、およびその利用

    出願日:2021/10/28

  8. 細胞培養基材、及び細胞培養方法

    出願日:2021/07/30

  9. 心筋細胞に分化させるための多能性幹細胞の製造方法

    出願日:2018/10/17

  10. 多層心筋組織培養物の製造方法

    出願日:2018/09/28

  11. ヒト由来iPS細胞から分化した心筋細胞においてβミオシン重鎖タンパク質を効率的に産生させる方法

    出願日:2017/03/03

  12. 環状心筋細胞塊

    劉莉, 李俊君

    出願日:2016/12/28

  13. 組織片

    劉莉, 李俊君, 南一成, 陳勇, 中辻憲夫

    出願日:2015/10/16

  14. 生分解性ポリマーを素材とした３次元大量培養、及び細胞移植を可能にする培養基材の開発

    亀井謙一郎, 劉莉, 中辻憲夫, 陳勇, 佐藤秀樹, グンゼ株式会社, 鈴木昌和, グンゼ株式会社

    出願日:2014/10/31

  15. 配列構造を示す細胞で構成される再生組織片を得る方法

    劉莉, 李俊君, 南一成, 陳勇, 中辻憲夫

    出願日:2014/10/16

  16. 細胞機能評価用デバイス

    劉莉, 李俊君, 南一成, 陳勇, 中辻憲夫

    出願日:2014/10/16

  17. 細胞培養用シート

    劉莉, 李俊君, 南一成, 陳勇, 中辻憲夫

    出願日:2014/10/16

  18. 細胞培養足場基材、マイクロ流体デバイス及びそれを用いたハイスループットナノファイバースクリーニング方法

    亀井謙一郎, 真下泰正, 劉莉, 陳勇

    出願日:2013/12/20

  19. ファイバー・オン・ファイバーを用いた多能性幹細胞の３次元培養方法及びそのための基材

    亀井謙一郎, 中辻憲夫, 劉莉, 陳勇

    出願日:2013/06/03

Institutional Repository 6

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Label-Free Raman Spectroscopy for Assessing Purity and Maturation of hiPSC-Derived Cardiac Tissue

    Li Junjun, Li Menglu, Nawa Yasunori, Liu Yuting, Bando Kazuki, Hua Ying, Sun Lifu, Fujita Satoshi, Sawa Yoshiki, Fujita Katsumasa, Liu Li

    Analytical Chemistry　Vol. 96　No. 39　p. 15765-15772　2024/09/18

  2. Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction

    Zhang Jingbo, Li Junjun, Qu Xiang, Liu Yuting, Sun Lifu, Harada Akima, Hua Ying, Sougawa Nagako, Tabata Akiko, Liu Li, Miyagawa Shigeru

    Bioactive Materials　Vol. 37　p. 533-548　2024/07/01

  3. The UDP-glucose/P2Y14 receptor axis promotes eosinophil-dependent large intestinal inflammation

    Liu Li, Ito Takayoshi, Li Bo, Tani Haruka, Okuzaki Daisuke, Motooka Daisuke, Miyazaki Hazuki, Ogino Takayuki, Nakamura Shota, Takeda Kiyoshi, Kayama Hisako

    International Immunology　Vol. 36　No. 4　p. 155-166　2024/04/04

  4. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment

    Li Junjun, Hua Ying, Liu Yuting, Qu Xiang, Zhang Jingbo, Ishida Masako, Yoshida Noriko, Tabata Akiko, Miyoshi Hayato, Shiba Mikio, Higo Shuichiro, Sougawa Nagako, Takeda Maki, Kawamura Takuji, Matsuura Ryohei, Okuzaki Daisuke, Toyofuku Toshihiko, Sawa Yoshiki, Liu Li, Miyagawa Shigeru

    iScience　Vol. 27　No. 2　2024/02/16

  5. Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts

    Zhang Jingbo, Li Junjun, Qu Xiang, Liu Yuting, Harada Akima, Hua Ying, Yoshida Noriko, Ishida Masako, Tabata Akiko, Sun Lifu, Liu Li, Miyagawa Shigeru

    Stem Cell Research and Therapy　Vol. 14　2023/12/20

  6. HiPSC-derived cardiac tissue for disease modeling and drug discovery

    Li Junjun, Hua Ying, Miyagawa Shigeru, Zhang Jingbo, Li Lingjun, Liu Li, Sawa Yoshiki

    International Journal of Molecular Sciences　Vol. 21　No. 23　2020/11/24