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Neutron and time-resolved X-ray crystallography reveal the substrate recognition and catalytic mechanism of human Nudix hydrolase MTH1.
Keisuke Hirata, Kana Fujimiya, Andreas Ostermann, Tobias E Schrader, Takeshi Hiromoto, Masataka Goto, Takao Arimori, Yu Hirano, Katsuhiro Kusaka, Taro Tamada, Teruya Nakamura
Proceedings of the National Academy of Sciences of the United States of America Vol. 122 No. 29 2025/07/22 Research paper (scientific journal)
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Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy
Martin P. Hosking, Soheila Shirinbak, Kyla Omilusik, Shilpi Chandra, Mika K. Kaneko, Angela Gentile, Susumu Yamamoto, Bishwas Shrestha, Joy Gran, Megan Boye, Demetrio Cardenas, Hannah Keegan, Samad Ibitokou, Carolina Pavon, Takahiro Mizoguchi, Tatsuya Ihara, Daisuke Nakayama, Ramzey Abujarour, Tom T. Lee, Raedun Clarke, Jode Goodridge, Eigen Peralta, Tatsuo Maeda, Junichi Takagi, Takao Arimori, Yukinari Kato, Bahram Valamehr
Cell Stem Cell 2025/06
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The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains
Yiwei Liu, Takahiro Mori, Yusei Ito, Kimiko Kuroki, Seiichiro Hayashi, Daisuke Kohda, Taro Shimizu, Tatsuhiro Ishida, Steve R. Roffler, Mika K. Kaneko, Yukinari Kato, Takao Arimori, Takamasa Teramoto, Kazuhiro Takemura, Kenta Ishibashi, Yoshiki Katayama, Katsumi Maenaka, Yoshimitsu Kakuta, Akio Kitao, Takeshi Mori
Journal of Controlled Release Vol. 380 p. 396-403 2025/04 Research paper (scientific journal)
Publisher: Elsevier BV
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CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
Shunya Ikeda, Kana Hasegawa, Yosuke Kogue, Takao Arimori, Ryuhei Kawamoto, Tansri Wibowo, Moto Yaga, Yuri Inada, Hirofumi Uehara, Miwa Matsubara, Mana Tachikawa, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Kentaro Fukushima, Jiro Fujita, Tomoaki Ueda, Shinsuke Kusakabe, Akihisa Hino, Michiko Ichii, Asao Hirose, Hirohisa Nakamae, Masayuki Hino, Takafumi Nakao, Megumu Inoue, Kyoko Yoshihara, Satoshi Yoshihara, Shuji Ueda, Tetsuro Tachi, Hideki Kuroda, Koki Murakami, Noriyuki Kijima, Haruhiko Kishima, Eri Igashira, Mari Murakami, Tsuyoshi Takiuchi, Tadashi Kimura, Takashi Hiroshima, Toru Kimura, Yasushi Shintani, Chihaya Imai, Kosuke Yusa, Ryota Mori, Takayuki Ogino, Hidetoshi Eguchi, Kiyoshi Takeda, Yusuke Oji, Atsushi Kumanogoh, Junichi Takagi, Naoki Hosen
Nature Cancer 2025/03/24 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Engineered DPP4 decoy confers broad-spectrum inhibition of MERS-CoV infection
Keisuke Nishioka, Yusuke Sakai, Daisuke Motooka, Naoko Iwata-Yoshikawa, Hiroaki Tojo, Satoaki Matoba, Noriyo Nagata, Takaaki Nakaya, Takao Arimori, Atsushi Hoshino
Cell Biomaterials p. 100018-100018 2025/03 Research paper (scientific journal)
Publisher: Elsevier BV
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Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies
Takao Arimori, Emiko Mihara, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K. Kaneko, Junichi Takagi, Yukinari Kato
Structure Vol. 32 No. 5 p. 536-549.e5 2024/05 Research paper (scientific journal)
Publisher: Elsevier BV
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Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system
Shunta Taminishi, Songling Li, Yusuke Higuchi, Yuhei Kirita, Daisuke Motooka, Yuki Ozaki, Takao Arimori, Nariko Ikemura, Yumi Itoh, Satoaki Matoba, Toru Okamoto, Junichi Takagi, Daron M Standley, Atsushi Hoshino
BioRxiv 2023/07/18
Publisher: Cold Spring Harbor Laboratory
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Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A. Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B. Wing, Daron M. Standley, Junichi Takagi, Kazuhiro Suzuki
Science Immunology Vol. 8 No. 81 2023/03/31 Research paper (scientific journal)
Publisher: American Association for the Advancement of Science (AAAS)
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De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function
Nozomi Sugano-Nakamura, Kyoko Matoba, Mika Hirose, Nasir K. Bashiruddin, Yukiko Matsunaga, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Takao Arimori, Hiroaki Suga, Junichi Takagi
Structure Vol. 30 No. 10 p. 1411-1423.e4 2022/10 Research paper (scientific journal)
Publisher: Elsevier BV
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Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy
Qianli Zhang, Akitoshi Miyamoto, Shin Watanabe, Takao Arimori, Masanori Sakai, Madoka Tomisaki, Tai Kiuchi, Junichi Takagi, Naoki Watanabe
Cell Reports Methods p. 100301-100301 2022/09 Research paper (scientific journal)
Publisher: Elsevier BV
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Engineering ACE2 decoy receptors to combat viral escapability
Takao Arimori, Nariko Ikemura, Toru Okamoto, Junichi Takagi, Daron M. Standley, Atsushi Hoshino
Trends in Pharmacological Sciences Vol. 43 No. 10 p. 838-851 2022/07 Research paper (scientific journal)
Publisher: Elsevier BV
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An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo
Nariko Ikemura, Shunta Taminishi, Tohru Inaba, Takao Arimori, Daisuke Motooka, Kazutaka Katoh, Yuhei Kirita, Yusuke Higuchi, Songling Li, Tatsuya Suzuki, Yumi Itoh, Yuki Ozaki, Shota Nakamura, Satoaki Matoba, Daron M Standley, Toru Okamoto, Junichi Takagi, Atsushi Hoshino
Science Translational Medicine Vol. 14 No. 650 2022/04/26 Research paper (scientific journal)
Publisher: American Association for the Advancement of Science (AAAS)
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Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant
Nariko Ikemura, Shunta Taminishi, Tohru Inaba, Takao Arimori, Daisuke Motooka, Kazutaka Katoh, Yuhei Kirita, Yusuke Higuchi, Songling Li, Tatsuya Suzuki, Yumi Itoh, Yuki Ozaki, Shota Nakamura, Satoaki Matoba, Daron M Standley, Toru Okamoto, Junichi Takagi, Atsushi Hoshino
BioRxiv 2021/12/23
Publisher: Cold Spring Harbor Laboratory
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Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues.
Yoshihiro Kobashigawa, Toshiya Ohara, Kosuke Morita, Yuya Toyota, Teruya Nakamura, Shunsuke Kotani, Takao Arimori, Soichiro Yamauchi, Chenjiang Liu, Masaya Kitazaki, Yukari Wakeyama-Miyazaki, Yoshiaki Suwa, Makiyo Uchida-Kamekura, Natsuki Fukuda, Takashi Sato, Makoto Nakajima, Junichi Takagi, Yuriko Yamagata, Hiroshi Morioka
Journal of biochemistry Vol. 170 No. 3 p. 379-387 2021/10/12 Research paper (scientific journal)
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Structural mechanism of laminin recognition by integrin
Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi
Nature Communications Vol. 12 No. 1 p. 4012-4012 2021/06/29 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura, Yusuke Sakai, Yumi Itoh, Fuminori Sugihara, Yoshiharu Matsuura, Satoaki Matoba, Toru Okamoto, Junichi Takagi, Atsushi Hoshino
Nature Communications Vol. 12 No. 1 p. 3802-3802 2021/06/21 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi
Nature Communications Vol. 12 No. 1 p. 1543-1543 2021/03/09 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems
Nobuhiro Sato, Rina Yogo, Saeko Yanaka, Anne Martel, Lionel Porcar, Ken Morishima, Rintaro Inoue, Taiki Tominaga, Takao Arimori, Junichi Takagi, Masaaki Sugiyama, Koichi Kato
The Journal of Biochemistry 2021/02/02 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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High affinity modified ACE2 receptors prevent SARS-CoV-2 infection
Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura, Yoshiharu Matsuura, Satoaki Matoba, Toru Okamoto, Junichi Takagi, Atsushi Hoshino
BioRxiv 2020/09/16
Publisher: Cold Spring Harbor Laboratory
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Site-specific epitope insertion into recombinant proteins using the MAP tag system.
Ayami Wakasa, Mika K Kaneko, Yukinari Kato, Junichi Takagi, Takao Arimori
Journal of biochemistry Vol. 168 No. 4 p. 375-384 2020/05/09 Research paper (scientific journal)
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Crystal structure of a mammalian Wnt-frizzled complex.
Hirai H, Matoba K, Mihara E, Arimori T, Takagi J
Nature structural & molecular biology Vol. 26 No. 5 p. 372-379 2019/05 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
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X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity
Nakamura Teruya, Hirata Keisuke, Fujimiya Kana, Chirifu Mami, Arimori Takao, Tamada Taro, Ikemizu Shinji, Yamagata Yuriko
INTERNATIONAL JOURNAL OF MICROGRAVITY SCIENCE AND APPLICATION Vol. 36 No. 1 2019
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Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy.
Brown ZP, Arimori T, Iwasaki K, Takagi J
Journal of structural biology Vol. 201 No. 3 p. 247-251 2018/03
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Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.
Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase
Nature Vol. 552 No. 7683 p. 101-105 2017/12/07
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Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus
Shuhei Sakakibara, Takao Arimori, Kazuo Yamashita, Hideyuki Jinzai, Daisuke Motooka, Shota Nakamura, Songling Li, Kazuya Takeda, Jun Katayama, Marwa Ali El Hussien, Masashi Narazaki, Toshio Tanaka, Daron M. Standley, Junichi Takagi, Hitoshi Kikutani
SCIENTIFIC REPORTS Vol. 7 No. 1 2017/11 Research paper (scientific journal)
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Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability
Takao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura-Kawakami, Junichi Takagi
STRUCTURE Vol. 25 No. 10 p. 1611-+ 2017/10 Research paper (scientific journal)
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Mechanistic basis for the recognition of laminin-511 by alpha 6 beta 1 integrin
Mamoru Takizawa, Takao Arimori, Yukimasa Taniguchi, Yu Kitago, Erika Yamashita, Junichi Takagi, Kiyotoshi Sekiguchi
SCIENCE ADVANCES Vol. 3 No. 9 2017/09 Research paper (scientific journal)
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Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
Shaimaa Waz, Teruya Nakamura, Keisuke Hirata, Yukari Koga-Ogawa, Mami Chirifu, Takao Arimori, Taro Tamada, Shinji Ikemizu, Yusaku Nakabeppu, Yuriko Yamagata
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 No. 7 p. 2785-2794 2017/02 Research paper (scientific journal)
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Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state
Yuki Fujii, Yukiko Matsunaga, Takao Arimori, Yu Kitago, Satoshi Ogasawara, Mika K. Kaneko, Yukinari Kato, Junichi Takagi
JOURNAL OF CELL SCIENCE Vol. 129 No. 7 p. 1512-1522 2016/04 Research paper (scientific journal)
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Crystal structure of endo-1,4-beta-glucanase from Eisenia fetida
Takao Arimori, Akihiro Ito, Masami Nakazawa, Mitsuhiro Ueda, Taro Tamada
JOURNAL OF SYNCHROTRON RADIATION Vol. 20 No. Pt 6 p. 884-889 2013/11 Research paper (scientific journal)
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Crystal structures of the catalytic domain of a novel glycohydrolase family 23 chitinase from Ralstonia sp. A-471 reveals a unique arrangement of the catalytic residues for inverting chitin hydrolysis
Takao Arimori, Noriko Kawamoto, Shoko Shinya, Nobuo Okazaki, Masami Nakazawa, Kazutaka Miyatake, Tamo Fukamizo, Mitsuhiro Ueda, Taro Tamada
Journal of Biological Chemistry Vol. 288 No. 26 p. 18696-18706 2013/06/28 Research paper (scientific journal)
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Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
Takao Arimori, Haruhiko Tamaoki, Teruya Nakamura, Hiroyuki Kamiya, Shinji Ikemizu, Yasumitsu Takagi, Toru Ishibashi, Hideyoshi Harashima, Mutsuo Sekiguchi, Yuriko Yamagata
Nucleic Acids Research Vol. 39 No. 20 p. 8972-8983 2011/11 Research paper (scientific journal)
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Crystallization and preliminary X-ray diffraction studies of the catalytic domain of a novel chitinase, a member of GH family 23, from the moderately thermophilic bacterium Ralstonia sp. A-471
Nobuo Okazaki, Takao Arimori, Masami Nakazawa, Kazutaka Miyatake, Mitsuhiro Ueda, Taro Tamada
Acta Crystallographica Section F: Structural Biology and Crystallization Communications Vol. 67 No. 4 p. 494-497 2011/04 Research paper (scientific journal)
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The Crystal Structure of the Green Tea Polyphenol (-)-Epigallocatechin Gallate-Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site
Masanori Miyata, Takashi Sato, Miyuki Kugimiya, Misato Sho, Teruya Nakamura, Shinji Ikemizu, Mami Chirifu, Mineyuki Mizuguchi, Yuko Nabeshima, Yoshiaki Suwa, Hiroshi Morioka, Takao Arimori, Mary Ann Suico, Tsuyoshi Shuto, Yasuhiro Sako, Mamiko Momohara, Tomoaki Koga, Saori Morino-Koga, Yuriko Yamagata, Hirofumi Kai
BIOCHEMISTRY Vol. 49 No. 29 p. 6104-6114 2010/07 Research paper (scientific journal)
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NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity
Hiroyuki Kamiya, Mika Hori, Takao Arimori, Mutsuo Sekiguchi, Yuriko Yamagata, Hideyoshi Harashima
DNA REPAIR Vol. 8 No. 10 p. 1250-1254 2009/10 Research paper (scientific journal)