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LU SHIOU-LING

LU SHIOU-LING

Graduate School of Dentistry Center for Frontier Oral Science, Assistant Professor

keyword Macrophage,Rab32/Rab38,Autophagy,endothelial cell,Streptococcus pyogenes

Education

  • 2011/04 - 2016/03, Osaka University, Graduate school of Frontier Biosciences phD
  • 2007/09 - 2014/07, National Cheng Kung University, The Institute of Basic Medical Sciences phD

Research History

  • 2021/10 - Present, Osaka University, Graduate School of Dentistry Center for Frontier Oral Science, Assistant professor
  • 2018/05 - 2021/09, Osaka University, Graduate School of Density, Assistant professor
  • 2016/04 - 2018/04, 日本学術振興会
  • 2011/04 - 2016/03, Osaka University, Graduate School of Frontier Biosciences, Graduate student

Research Areas

  • Life sciences, Molecular biology, Rab32/Rab38
  • Life sciences, Molecular biology, VEGF
  • Life sciences, Functional biochemistry, Autophagy
  • Life sciences, Cell biology, Endothelial cell
  • Life sciences, Bacteriology, Streptococcus pyogenes

Professional Memberships

  • Japanese Society of Bacteriology
  • The Japanese Biochemical Society
  • 日本細胞生物
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Papers

  • Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts, Cell Structure and Function, 2023/10
  • Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages, Kazuya Noda,Shiou-Ling Lu,Siyu Chen,Kanako Tokuda,Yangjie Li,Feike Hao,Yoh Wada,Ge-Hong Sun-Wada,Shinya Murakami,Mitsunori Fukuda,Takashi Itoh,Takeshi Noda, Journal of Biological Chemistry, ASBMB, Vol. 299, 2023/08
  • VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells, Shiou-Ling Lu,Takeshi Noda, Autophagy Reports, Informa UK Limited, Vol. 1, No. 1, p. 555-558, 2022/12/31
  • VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes, Shiou-Ling Lu,Hiroko Omori,Yi Zhou,Yee-Shin Lin,Ching-Chuan Liu,Jiunn-Jong Wu,Takeshi Noda, mBio, 2022/07/05
  • The mechanism of bacterial replication in endothelial cells, Tsuyoshi Kawabata,Shiou-Ling Lu,Tamotsu Yoshimori, J-GLOBAL, Vol. 70, No. 5, p. 532-536, 2018/11
  • Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes, Shiou-Ling Lu,Tsuyoshi Kawabata,Yi-Lin Cheng,Hiroko Omori,Maho Hamasaki,Tatsuya Kusaba,Ryo Iwamoto,Hirokazu Arimoto,Takeshi Noda,Yee-Shin Lin,Tamotsu Yoshimori, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 13, No. 7, 2017/07
  • Insufficient Acidification of Autophagosomes Facilitates Group A Streptococcus Survival and Growth in Endothelial Cells, Shiou-Ling Lu,Chih-Feng Kuo,Hao-Wen Chen,Yi-Shuan Yang,Ching-Chuan Liu,Robert Anderson,Jiunn-Jong Wu,Yee-Shin Lin, MBIO, AMER SOC MICROBIOLOGY, Vol. 6, No. 5, 2015/09
  • Plasma kallistatin levels in patients with severe community-acquired pneumonia, Wei-Chieh Lin,Shiou-Ling Lu,Chiou-Feng Lin,Chang-Wen Chen,Lee Chao,Julie Chao,Yee-Shin Lin, CRITICAL CARE, BIOMED CENTRAL LTD, Vol. 17, No. 1, 2013
  • Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection., Shiou-Ling Lu,Chiau-Yuang Tsai,Yueh-Hsia Luo,Chih-Feng Kuo,Wei-Chieh Lin,Yu-Tzu Chang,Jiunn-Jong Wu,Woei-Jer Chuang,Ching-Chuan Liu,Lee Chao,Julie Chao,Yee-Shin Lin, Antimicrobial Agents and Chemotherapy, Vol. 57, p. 5366-5372, 2013
  • Opposing roles of RUBCN isoforms in autophagy and memory B cell generation., Chao-Yuan Tsai,Shuhei Sakakibara,Yu-Diao Kuan,Hiroko Omori,Maruwa Ali El Hussien,Daisuke Okuzaki,Shiou-Ling Lu,Takeshi Noda,Keisuke Tabata,Shuhei Nakamura,Tamotsu Yoshimori,Hitoshi Kikutani, Science signaling, Vol. 16, No. 803, 2023/09/19
  • Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations, Sumiko Ikari,Qiang Yang,Shiou-Ling Lu,Yuancai Liu,Feike Hao,Guoqiang Tong,Shiguang Lu,Takeshi Noda, Antioxidants, MDPI AG, Vol. 10, No. 8, p. 1217-1217, 2021/07/29
  • Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan., Sumiko Ikari,Shiou-Ling Lu,Feike Hao,Kenta Imai,Yasuhiro Araki,Yo-Hei Yamamoto,Chao-Yuan Tsai,Yumi Nishiyama,Nobukazu Shitan,Tamotsu Yoshimori,Takanobu Otomo,Takeshi Noda, PloS one, Vol. 15, No. 3, 2020
  • Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells., Cheng-Lu Hsieh,Shu-Ying Hsieh,Hsuan-Min Huang,Shiou-Ling Lu,Hiroko Omori,Po-Xing Zheng,Yen-Ning Ho,Yi-Lin Cheng,Yee-Shin Lin,Chuan Chiang-Ni,Pei-Jane Tsai,Shu-Ying Wang,Ching-Chuan Liu,Takeshi Noda,Jiunn-Jong Wu, Frontiers in microbiology, Vol. 11, p. 117-117, 2020
  • Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy., Yi-Lin Cheng,Chih-Feng Kuo,Shiou-Ling Lu,Omori Hiroko,Ya-Na Wu,Cheng-Lu Hsieh,Takeshi Noda,Shang-Rung Wu,Robert Anderson,Chiou-Feng Lin,Chia-Ling Chen,Jiunn-Jong Wu,Yee-Shin Lin, mBio, Vol. 10, No. 5, 2019/10/01
  • Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus, Yi-Lin Cheng,Yan-Wei Wu,Chih-Feng Kuo,Shiou-Ling Lu,Fu-Tong Liu,Robert Anderson,Chiou-Feng Lin,Yi-Ling Liu,Wan-Yu Wang,Ying-Da Chen,Po-Xing Zheng,Jiunn-Jong Wu,Yee-Shin Lin, MBIO, AMER SOC MICROBIOLOGY, Vol. 8, No. 4, 2017/07
  • Regulatory Role of GSK-3 beta on NF-kappa B, Nitric Oxide, and TNF-alpha in Group A Streptococcal Infection, Yu-Tzu Chang,Chia-Ling Chen,Chiou-Feng Lin,Shiou-Ling Lu,Miao-Huei Cheng,Chih-Feng Kuo,Yee-Shin Lin, MEDIATORS OF INFLAMMATION, HINDAWI LTD, Vol. 2013, 2013
  • Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection, Chih-Hsin Hung,Nina Tsao,Yi-Fang Zeng,Shiou-Ling Lu,Chuan Chiang-Ni,Yee-Shin Lin,Jiunn-Jong Wu,Chih-Feng Kuo, MEDICAL MICROBIOLOGY AND IMMUNOLOGY, SPRINGER, Vol. 201, No. 3, p. 357-369, 2012/08
  • Size-Dependent Attenuation of TLR9 Signaling by Gold Nanoparticles in Macrophages, Chiau-Yuang Tsai,Shiou-Ling Lu,Chia-Wen Hu,Chen-Sheng Yeh,Gwo-Bin Lee,Huan-Yao Lei, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 188, No. 1, p. 68-76, 2012/01
  • Dextromethorphan Efficiently Increases Bactericidal Activity, Attenuates Inflammatory Responses, and Prevents Group A Streptococcal Sepsis, Ming-Han Li,Yueh-Hsia Luo,Chiou-Feng Lin,Yu-Tzu Chang,Shiou-Ling Lu,Chih-Feng Kuo,Jau-Shyong Hong,Yee-Shin Lin, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMER SOC MICROBIOLOGY, Vol. 55, No. 3, p. 967-973, 2011/03
  • Inhibition of group A streptococcal infection by Melaleuca alternifolia (tea tree) oil concentrate in the murine model, N. Tsao,C. -F. Kuo,H. -Y. Lei,S. -L. Lu,K. -J Huang, JOURNAL OF APPLIED MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 108, No. 3, p. 936-944, 2010/03

Misc.

  • The multiplication of invasive Streptococcus pyogenes in endothelial cell accompanies autophagy formation, Shiou-Ling Lu,Yee-Shin Lin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 184, 2010/04

Awards

  • 25th Osaka University School of Dentistry Yumikura Encouragement Award, 2023/03

Presentations

  • VEGF-mediated antimicrobial effects in endothelial cells, Lu Shiou-Ling, The Molecular Biology Society of Japan, 2019/12/03
  • Messages of graduated student from Graduate School of Frontier Biosciences, Lu Shiou-Ling, 2017/09
  • How does Taiwan’s woman survive in research field in Taiwan vs. in Japan?, Lu Shiou-Ling, JSPS Science Dialogue, 2016/06
  • Intrinsically insufficient xenophagy causes GAS growth in endothelial cells., Lu Shiou-Ling,Tsuyoshi Kawabata,Hirokazu Arimoto,Tamotsu Yoshimori, JSPS A3 Foresight program: International A3 Foresight Symposium on Autophagy, 2016/03