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LU SHIOU-LING
LU SHIOU-LING
LU SHIOU-LING
LU SHIOU-LING
Institutional repository
Graduate School of Dentistry　Center for Frontier Oral Science，Assistant Professor

keyword microautophagy，Macrophage，Rab32/Rab38，Autophagy，endothelial cell，Streptococcus pyogenes

Institutional repository

Research History 5

  1. 2023/04 - Present
    The University of Osaka　Graduate School of Dentistry, Center for Frontier Oral Science/Department of Oral Cellular Biology

  2. 2021/10 - 2023/03
    Osaka University　Graduate School of Dentistry, Center for Frontier Oral Science　Assistant professor

  3. 2018/05 - 2021/09
    Osaka University　Graduate School of Density　Assistant professor

  4. 2016/04 - 2018/04
    Japan Society for the Promotion of Science

  5. 2011/04 - 2016/03
    Osaka University　Graduate School of Frontier Biosciences　Graduate student

Education 2

  1. Osaka University　Graduate school of Frontier Biosciences phD

    2011/04 - 2016/03

  2. National Cheng Kung University　College of Medicine, The Institute of Basic Medical Sciences phD

    2007/09 - 2014/07

Professional Memberships 4

  1. Japanese Society of Bacteriology

  2. The Japanese Biochemical Society

  3. 日本細胞生物

  4. THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Areas 7

  1. Life sciences / Cell biology / microautophagy

  2. Life sciences / Cell biology / macrophage

  3. Life sciences / Molecular biology / Rab32/Rab38

  4. Life sciences / Molecular biology / VEGF

  5. Life sciences / Cell biology / Autophagy

  6. Life sciences / Cell biology / Endothelial cell

  7. Life sciences / Bacteriology / Streptococcus pyogenes

Awards 7

  1. 25th Osaka University School of Dentistry Yumikura Encouragement Award

    Lu Shiou-Ling　2023/03

  2. JSPS Fellowship Programs for Overseas Researchers

    JSPS　2016/04

  3. Ministry of Science and Techonology Overseas Project for Post Graduate Research

    National Science and Technology Council, R.O.C　2011

  4. Travel Award

    Lu Shiou-Ling　National Science and Technology Council, R.O.C　2010

  5. 大学院生赴日研究奨学金

    呂唀菱(ルショオリン　財團法人日本交流協会　2010

  6. 2007年度 国立成功大学医学院研究発表会、口頭発表優勝

    呂唀菱(ルショオリン　台湾国立成功大学　2007

  7. 2006年度 国立成功大学医学院研究発表会、ポスター発表優勝

    呂唀菱(ルショオリン　台湾国立成功大学　2006

Papers 24

  1. Evidence that mitochondria in macrophages are destroyed by microautophagy

    Shiou-Ling Lu, Siyu Chen, Kazuya Noda, Yangjie Li, Chao-Yuan Tsai, Hiroko Omori, Yumiko Kato, Zidi Zhang, Bohan Chen, Kanako Tokuda, Tongxin Zheng, Masahiro Wakita, Eiji Hara, Mitsunori Fukuda, Yoh Wada, Eiji Morita, Narikazu Uzawa, Shinya Murakami, Takeshi Noda

    Nature Communications　Vol. 16　No. 1　2025/08/30　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  2. The emerging role of Rab proteins in osteoclast organelle biogenesis and function

    Shiou-Ling Lu, Takeshi Noda

    Biochemical Society Transactions　Vol. 52　No. 6　p. 2469-2475　2024/12/19　Research paper (scientific journal)

  3. Capsule-deficient group A Streptococcus evades autophagy-mediated killing in macrophages

    Yong-An Shi, Shiou-Ling Lu, Takeshi Noda, Cheng-Hsun Chiu, Chuan Chiang-Ni

    mBio　Vol. 15　No. 7　2024/07/17　Research paper (scientific journal)

    Publisher: American Society for Microbiology

  4. Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages

    Kazuya Noda, Shiou-Ling Lu, Siyu Chen, Kanako Tokuda, Yangjie Li, Feike Hao, Yoh Wada, Ge-Hong Sun-Wada, Shinya Murakami, Mitsunori Fukuda, Takashi Itoh, Takeshi Noda

    Journal of Biological Chemistry　Vol. 299　2023/08　Research paper (scientific journal)

    Publisher: ASBMB

  5. Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts

    Kanako Tokuda, Shiou-Ling Lu, Zidi Zhang, Yumiko Kato, Siyu Chen, Kazuya Noda, Katsutoshi Hirose, Yu Usami, Narikazu Uzawa, Shinya Murakami, Satoru Toyosawa, Mitsunori Fukuda, Ge-Hong Sun-Wada, Yoh Wada, Takeshi Noda

    Cell Structure and Function　Vol. 48　No. 2　p. 223-239　2023　Research paper (scientific journal)

    Publisher: Japan Society for Cell Biology

  6. VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells

    Shiou-Ling Lu, Takeshi Noda

    Autophagy Reports　Vol. 1　No. 1　p. 555-558　2022/12/31　Research paper (scientific journal)

    Publisher: Informa UK Limited

  7. VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes

    Shiou-Ling Lu, Hiroko Omori, Yi Zhou, Yee-Shin Lin, Ching-Chuan Liu, Jiunn-Jong Wu, Takeshi Noda

    mBio　Vol. 13　No. 4　2022/08/30　Research paper (scientific journal)

    Publisher: American Society for Microbiology

  8. Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy.

    Yi-Lin Cheng, Chih-Feng Kuo, Shiou-Ling Lu, Omori Hiroko, Ya-Na Wu, Cheng-Lu Hsieh, Takeshi Noda, Shang-Rung Wu, Robert Anderson, Chiou-Feng Lin, Chia-Ling Chen, Jiunn-Jong Wu, Yee-Shin Lin

    mBio　Vol. 10　No. 5　2019/10/01　Research paper (scientific journal)

    Publisher: NLM (Medline)

  9. The mechanism of bacterial replication in endothelial cells

    Tsuyoshi Kawabata, Shiou-Ling Lu, Tamotsu Yoshimori

    J-GLOBAL　Vol. 70　No. 5　p. 532-536　2018/11　Research paper (scientific journal)

  10. Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

    Shiou-Ling Lu, Tsuyoshi Kawabata, Yi-Lin Cheng, Hiroko Omori, Maho Hamasaki, Tatsuya Kusaba, Ryo Iwamoto, Hirokazu Arimoto, Takeshi Noda, Yee-Shin Lin, Tamotsu Yoshimori

    PLOS PATHOGENS　Vol. 13　No. 7　2017/07　Research paper (scientific journal)

  11. Insufficient Acidification of Autophagosomes Facilitates Group A Streptococcus Survival and Growth in Endothelial Cells

    Shiou-Ling Lu, Chih-Feng Kuo, Hao-Wen Chen, Yi-Shuan Yang, Ching-Chuan Liu, Robert Anderson, Jiunn-Jong Wu, Yee-Shin Lin

    MBIO　Vol. 6　No. 5　2015/09　Research paper (scientific journal)

  12. Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection.

    Shiou-Ling Lu, Chiau-Yuang Tsai, Yueh-Hsia Luo, Chih-Feng Kuo, Wei-Chieh Lin, Yu-Tzu Chang, Jiunn-Jong Wu, Woei-Jer Chuang, Ching-Chuan Liu, Lee Chao, Julie Chao, Yee-Shin Lin

    Antimicrobial Agents and Chemotherapy　Vol. 57　p. 5366-5372　2013　Research paper (scientific journal)

  13. Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats

    Shengsen Yang, Nayuka Usami, Shiou-Ling Lu, Wakana Oda, Hiroharu Maegawa, Hitoshi Niwa, Chiho Kudo

    Biochemical and Biophysical Research Communications　Vol. 744　p. 151178-151178　2025/01　Research paper (scientific journal)

    Publisher: Elsevier BV

  14. Opposing roles of RUBCN isoforms in autophagy and memory B cell generation.

    Chao-Yuan Tsai, Shuhei Sakakibara, Yu-Diao Kuan, Hiroko Omori, Maruwa Ali El Hussien, Daisuke Okuzaki, Shiou-Ling Lu, Takeshi Noda, Keisuke Tabata, Shuhei Nakamura, Tamotsu Yoshimori, Hitoshi Kikutani

    Science signaling　Vol. 16　No. 803　2023/09/19　Research paper (scientific journal)

  15. Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations

    Sumiko Ikari, Qiang Yang, Shiou-Ling Lu, Yuancai Liu, Feike Hao, Guoqiang Tong, Shiguang Lu, Takeshi Noda

    Antioxidants　Vol. 10　No. 8　p. 1217-1217　2021/07/29　Research paper (scientific journal)

    Publisher: MDPI AG

  16. Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan.

    Sumiko Ikari, Shiou-Ling Lu, Feike Hao, Kenta Imai, Yasuhiro Araki, Yo-Hei Yamamoto, Chao-Yuan Tsai, Yumi Nishiyama, Nobukazu Shitan, Tamotsu Yoshimori, Takanobu Otomo, Takeshi Noda

    PloS one　Vol. 15　No. 3　2020　Research paper (scientific journal)

  17. Nicotinamide Increases Intracellular NAD+ Content to Enhance Autophagy-Mediated Group A Streptococcal Clearance in Endothelial Cells.

    Cheng-Lu Hsieh, Shu-Ying Hsieh, Hsuan-Min Huang, Shiou-Ling Lu, Hiroko Omori, Po-Xing Zheng, Yen-Ning Ho, Yi-Lin Cheng, Yee-Shin Lin, Chuan Chiang-Ni, Pei-Jane Tsai, Shu-Ying Wang, Ching-Chuan Liu, Takeshi Noda, Jiunn-Jong Wu

    Frontiers in microbiology　Vol. 11　p. 117-117　2020

  18. Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus

    Yi-Lin Cheng, Yan-Wei Wu, Chih-Feng Kuo, Shiou-Ling Lu, Fu-Tong Liu, Robert Anderson, Chiou-Feng Lin, Yi-Ling Liu, Wan-Yu Wang, Ying-Da Chen, Po-Xing Zheng, Jiunn-Jong Wu, Yee-Shin Lin

    MBIO　Vol. 8　No. 4　2017/07　Research paper (scientific journal)

  19. Regulatory Role of GSK-3 beta on NF-kappa B, Nitric Oxide, and TNF-alpha in Group A Streptococcal Infection

    Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

    MEDIATORS OF INFLAMMATION　Vol. 2013　2013　Research paper (scientific journal)

  20. Plasma kallistatin levels in patients with severe community-acquired pneumonia

    Wei-Chieh Lin, Shiou-Ling Lu, Chiou-Feng Lin, Chang-Wen Chen, Lee Chao, Julie Chao, Yee-Shin Lin

    CRITICAL CARE　Vol. 17　No. 1　2013　Research paper (scientific journal)

  21. Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection

    Chih-Hsin Hung, Nina Tsao, Yi-Fang Zeng, Shiou-Ling Lu, Chuan Chiang-Ni, Yee-Shin Lin, Jiunn-Jong Wu, Chih-Feng Kuo

    MEDICAL MICROBIOLOGY AND IMMUNOLOGY　Vol. 201　No. 3　p. 357-369　2012/08　Research paper (scientific journal)

  22. Size-Dependent Attenuation of TLR9 Signaling by Gold Nanoparticles in Macrophages

    Chiau-Yuang Tsai, Shiou-Ling Lu, Chia-Wen Hu, Chen-Sheng Yeh, Gwo-Bin Lee, Huan-Yao Lei

    JOURNAL OF IMMUNOLOGY　Vol. 188　No. 1　p. 68-76　2012/01　Research paper (scientific journal)

  23. Dextromethorphan Efficiently Increases Bactericidal Activity, Attenuates Inflammatory Responses, and Prevents Group A Streptococcal Sepsis

    Ming-Han Li, Yueh-Hsia Luo, Chiou-Feng Lin, Yu-Tzu Chang, Shiou-Ling Lu, Chih-Feng Kuo, Jau-Shyong Hong, Yee-Shin Lin

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　Vol. 55　No. 3　p. 967-973　2011/03　Research paper (scientific journal)

  24. Inhibition of group A streptococcal infection by Melaleuca alternifolia (tea tree) oil concentrate in the murine model

    N. Tsao, C. -F. Kuo, H. -Y. Lei, S. -L. Lu, K. -J Huang

    JOURNAL OF APPLIED MICROBIOLOGY　Vol. 108　No. 3　p. 936-944　2010/03　Research paper (scientific journal)

Misc. 1

  1. The multiplication of invasive Streptococcus pyogenes in endothelial cell accompanies autophagy formation

    Shiou-Ling Lu, Yee-Shin Lin

    JOURNAL OF IMMUNOLOGY　Vol. 184　2010/04　Research paper, summary (international conference)

Presentations 9

  1. Mitochondria in macrophages are destroyed by microautophagy

    Lu Shiou-Ling

    The 11th International Symposium on Autophagy　2025/11/19

  2. Rab32/Rab38-リソソーム関連オルガネラのマイクロオートファジーを介したミトコンドリアと脂肪滴分解機構

    呂唀菱(ルショオリン

    第2 回 国際先導研究リトリート/第17 回 オートファジー研究会　2025/10/01

  3. Mitochondrial autophagy is carried out by microautophagy in macrophages

    Lu Shiou-Ling

    2024/11/06

  4. Mitochondrial autophagy is carried out by microautophagy in macrophages

    Lu Shiou-Ling

    2024/10/17

  5. Mitochondrial autophagy is carried out by microautophagy in macrophages

    Lu Shiou-Ling

    The 10th International Symposium on Autophagy　2022/10/24

  6. VEGF-mediated antimicrobial effects in endothelial cells

    Lu Shiou-Ling

    The Molecular Biology Society of Japan　2019/12/03

  7. Intrinsically insufficient xenophagy causes GAS growth in endothelial cells.

    Lu Shiou-Ling, Tsuyoshi Kawabata, Hirokazu Arimoto, Tamotsu Yoshimori

    JSPS A3 Foresight program: International A3 Foresight Symposium on Autophagy　2016/03

  8. Messages of graduated student from Graduate School of Frontier Biosciences

    Lu Shiou-Ling

    2017/09

  9. How does Taiwan’s woman survive in research field in Taiwan vs. in Japan?

    Lu Shiou-Ling

    JSPS Science Dialogue　2016/06

Institutional Repository 3

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Hormonal mechanisms in the paraventricular nuclei associated with hyperalgesia in Parkinson's disease model rats

    Yang Shengsen, Usami Nayuka, Lu Shiou-Ling, Oda Wakana, Maegawa Hiroharu, Niwa Hitoshi, Kudo Chiho

    Biochemical and Biophysical Research Communications　Vol. 744　2025/01/01

  2. 血管内皮増殖因子の新たな役割 : 殺菌作用増強効果の発見

    Lu Shiou-Ling, 野田 健司

    The Journal of Osaka University Dental Society　Vol. 67　No. 2　p. 17-19　2023/06/30

  3. The mechanism behind insufficient Streptococcus pyogenes clearance by autophagy in endothelial cells compared to epithelial cells.

    Lu Shiou-Ling