Alternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA-Binding Protein 43 kDa Functions

Takashi Miwa, Eriko Takeuchi, Kotaro Ogawa, Rehab F. Abdelhamid, Junko Morita, Yuri Hiraki, Yoshiaki Yasumizu, Yamami Nakamura, Naganari Ohkura, Yuko Saito, Shigeo Murayama, Yoshitaka Nagai, Hideki Mochizuki, Seiichi Nagano

Neurology and Clinical Neuroscience　2025　Research paper (scientific journal)

A case of cerebral amyloid angiopathy with ipsilateral tau and contralateral amyloid PET uptake related to cadaveric dura mater implanted in childhood

Yuki Hatakeyama, Atsushi Michael Kimura, Shintaro Tsuboguchi, Mikhail Ratanov, Kosei Nakamura, Masahiro Hatakeyama, Yukimi Nakamura, Masaki Watanabe, Yoshihiro Murakami, Yuko Saito, Shigeo Murayama, Kensaku Kasuga, Takeshi Ikeuchi, Hironaka Igarashi, Osamu Onodera, Hitoshi Shimada

European Journal of Nuclear Medicine and Molecular Imaging　2024/12/19　Research paper (scientific journal)

Chronic inflammatory demyelinating polyradiculoneuropathy with severe central nervous system demyelination: a clinicopathological study

Beck G., Yamashita R., Kawai M., Yamamura R., Okuno T., Matsui M., Toyooka K., Morii E., Mochizuki H., Murayama S.

Frontiers in Immunology　Vol. 15　2024/12/05

スーパー臨床神経病理カンファレンス(第11回) 進行性の左上下肢の使いにくさとふらつきを呈した51歳男性例

松原 知康, 山上 圭, 藤田 浩司, 齊藤 祐子, 村山 繁雄, 和泉 唯信

BRAIN and NERVE: 神経研究の進歩　Vol. 76　No. 12　p. 1361-1365　2024/12

Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation.

Masanori Kurihara, Akira Arakawa, Aya Midori Tokumaru, Tomoyasu Matsubara, Hiroto Eguchi, Yasushi Shimo, Masato Hasegawa, Kazutomi Kanemaru, Katsuhiko Takeda, Atsushi Iwata, Shigeo Murayama, Yuko Saito

eNeurologicalSci　Vol. 37　p. 100526-100526　2024/12　Research paper (scientific journal)

Morphometry of choroid plexus epithelial cells in neurodegenerative diseases.

Ryuta Murakami, Yoichi Chiba, Nobuyuki Miyatake, Yumi Miyai, Koichi Matsumoto, Keiji Wakamatsu, Yuko Saito, Manato Hara, Shigeo Murayama, Masaki Ueno

Neuropathology : official journal of the Japanese Society of Neuropathology　2024/11/27　Research paper (scientific journal)

Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice

Kenichi Nagata, Shoko Hashimoto, Daisuke Joho, Ryo Fujioka, Yukio Matsuba, Misaki Sekiguchi, Naomi Mihira, Daisuke Motooka, Yu-Chen Liu, Daisuke Okuzaki, Masataka Kikuchi, Shigeo Murayama, Takaomi C. Saido, Hiroshi Kiyama, Hiroki Sasaguri

eneuro　p. ENEURO.0260-24.2024　2024/11/26　Research paper (scientific journal)

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation.

Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C Saido, Takashi Saito, Koji Yamanaka

Cell death & disease　Vol. 15　No. 11　p. 858-858　2024/11/26　Research paper (scientific journal)

A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson's disease.

Akira Arakawa, Shigeo Murayama, Satoru Morimoto, Tomoyasu Matsubara, Renpei Sengoku, Masashi Kameyama, Aya M Tokumaru, Airi Tarutani, Masato Hasegawa, Atsushi Iwata, Tatsushi Toda, Yuko Saito

Journal of neurology　2024/10/15

Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology.

Gabor G Kovacs, Lea T Grinberg, Glenda Halliday, Irina Alafuzoff, Brittany N Dugger, Shigeo Murayama, Shelley L Forrest, Ivan Martinez-Valbuena, Hidetomo Tanaka, Tomoya Kon, Koji Yoshida, Zane Jaunmuktane, Salvatore Spina, Peter T Nelson, Steve Gentleman, Javier Alegre-Abarrategui, Geidy E Serrano, Vitor Ribeiro Paes, Masaki Takao, Koichi Wakabayashi, Toshiki Uchihara, Mari Yoshida, Yuko Saito, Julia Kofler, Roberta Diehl Rodriguez, Ellen Gelpi, Johannes Attems, John F Crary, William W Seeley, John E Duda, C Dirk Keene, John Woulfe, David Munoz, Colin Smith, Edward B Lee, Manuela Neumann, Charles L White 3rd, Ann C McKee, Dietmar R Thal, Kurt Jellinger, Bernardino Ghetti, Ian R A Mackenzie, Dennis W Dickson, Thomas G Beach

Movement disorders : official journal of the Movement Disorder Society　2024/10/03　Research paper (scientific journal)

Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies.

Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa

Scientific reports　Vol. 14　No. 1　p. 22892-22892　2024/10/02　Research paper (scientific journal)

老化とアミロイドβ蓄積に伴う大脳皮質での青斑核ノルアドレナリン神経軸索の変性様式

榊原 泰史, 廣田 湧, 森島 真帆, 佐野 輝典, 高尾 昌樹, 村山 繁雄, 齊藤 祐子, 関谷 倫子, 飯島 浩一

Dementia Japan　Vol. 38　No. 4　p. 677-677　2024/10

アルツハイマー病プレクリニカル期におけるバイオマーカーリン酸化タウの脳内局在解析

廣田 湧, 榊原 泰史, 森島 真帆, 佐野 輝典, 高尾 昌樹, 村山 繁雄, 齊藤 祐子, 飯島 浩一, 関谷 倫子

Dementia Japan　Vol. 38　No. 4　p. 699-699　2024/10

アルツハイマー病のポリジェニックリスクスコア層別化によるマルチオミックス解析

菊地 正隆, 宮下 哲典, 廣田 湧, 原 範和, 長谷川 舞衣, 榊原 泰史, 関谷 倫子, 齊藤 祐子, 村山 繁雄, 飯島 浩一, 池内 健

Dementia Japan　Vol. 38　No. 4　p. 723-723　2024/10

【学術研究支援の最先端】コホート・生体試料支援プラットフォーム(CoBiA) ブレインリソースの整備と活用支援 生前画像・死後脳病理連関による実証研究 動的神経病理(dynamic neuropathology)

松原 知康, 村山 繁雄, 齊藤 祐子

生体の科学　Vol. 75　No. 5　p. 496-497　2024/10

動的・分子・疫学神経病理の脳神経学会への貢献 アルツハイマー病及び他の神経変性疾患における脳脊髄液リン酸化tau・アミロイドβ42異常の病理学的背景

栗原 正典, 松原 知康, 森本 悟, 荒川 晶, 金丸 和富, 岩田 淳, 村山 繁雄, 齊藤 祐子

臨床神経学　Vol. 64　No. Suppl.　p. S74-S74　2024/10

動的・分子・疫学神経病理の脳神経学会への貢献 動的神経病理 123I-MIBG心交感神経シンチグラフィの診断能研究

松原 知康, 亀山 征史, 和泉 唯信, 村山 繁雄, 齊藤 祐子

臨床神経学　Vol. 64　No. Suppl.　p. S74-S74　2024/10

高齢者連続剖検コホートを用いた脳幹・基底核の嗜銀顆粒の分布に関する検討

荒川 晶, 塩谷 彩子, 松原 知康, 原 愛徒, 仙石 錬平, 村山 繁雄, 戸田 達史, 齊藤 祐子

臨床神経学　Vol. 64　No. Suppl.　p. S338-S338　2024/10

自律神経症状を有するLewy小体病患者におけるLewy関連病理の検討

原 愛徒, 村山 繁雄, 荒川 晶, 松原 知康, 戸田 達史, 齊藤 祐子

臨床神経学　Vol. 64　No. Suppl.　p. S338-S338　2024/10

孤発性筋萎縮性側索硬化症患者運動ニューロンの解析

赤松 舞里乃, 今村 恵子, 江浪 貴子, 永橋 文子, 月田 香代子, 森島 真帆, 松原 知康, 齊藤 祐子, 村山 繁雄, 和泉 唯信, 井上 治久

臨床神経学　Vol. 64　No. Suppl.　p. S441-S441　2024/10

家族性筋萎縮性側索硬化症患者運動ニューロンの解析

鈴木 葉南, 今村 恵子, 江浪 貴子, 永橋 文子, 月田 香代子, 森島 真帆, 松原 知康, 齋藤 祐子, 村山 繁雄, 和泉 唯信, 井上 治久

臨床神経学　Vol. 64　No. Suppl.　p. S442-S442　2024/10

高齢者の非アルツハイマー型認知症の臨床と病理 高齢者のLewy小体病

松原 知康, 和泉 唯信, 村山 繁雄, 齊藤 祐子

Dementia Japan　Vol. 38　No. 4　p. 649-649　2024/10

高齢者ブレインバンクにおける直近10年間の嗜銀顆粒性疾患の有病率,生前診断の検討

荒川 晶, 原 愛徒, 松原 知康, 村山 繁雄, 齊藤 祐子

Dementia Japan　Vol. 38　No. 4　p. 671-671　2024/10

αシヌクレイン線維の構造と翻訳後修飾

田平 万莉奈, 亀谷 富由樹, 高尾 昌樹, 松原 知康, 長谷川 一子, 吉田 眞理, 齊藤 祐子, 村山 繁雄, 長谷川 成人

Dementia Japan　Vol. 38　No. 4　p. 672-672　2024/10

アミロイドPET陽性であったLewy小体型認知症の一剖検例

高嶋 浩嗣, 寺田 達弘, 川口 典彦, 松平 敬史, 荒木 保清, 杉浦 明, 尾内 康臣, 松原 知康, 原 愛徒, 齊藤 祐子, 村山 繁雄, 小尾 智一

国立病院総合医学会講演抄録集　Vol. 78回　p. P2-2　2024/10

Clinical phenotypes and CSF phospho-tau in NOTCH2NLC-related neuronal intranuclear inclusion disease(タイトル和訳中)

Kurihara Masanori, Sengoku Renpei, Morimoto Satoru, Mitsutake Akihiko, Ishiura Hiroyuki, Higashihara Mana, Tokumaru Aya Midori, Kanemaru Kazutomi, Saito Yuko, Murayama Shigeo, Iwata Atsushi

臨床神経学　Vol. 64　No. Suppl.　p. S265-S265　2024/10

The diversity of Aβ seeds in Alzheimer's disease brains underlying Aβ pathological heterogeneity(タイトル和訳中)

Uchigami Hirokazu, Kashiwagi-hakozaki Mayu, Arakawa Akira, Matsubara Tomoyasu, Murayama Shigeo, Saito Yuko, Toda Tatsushi, Hashimoto Tadafumi, Iwatsubo Takeshi

臨床神経学　Vol. 64　No. Suppl.　p. S360-S360　2024/10

ALSにおける上位運動ニューロン病変の診断 Threshold tracking TMSと18F-THK5351 PETによる発症部位別検討

東原 真奈, 石橋 賢士, 栗原 正典, 小森 雄太, 高橋 健祐, 舟川 開, 井原 涼子, 畑中 裕己, 園生 雅弘, 村山 繁雄, 徳丸 阿耶, 石井 賢二, 岩田 淳

臨床神経生理学　Vol. 52　No. 5　p. 631-631　2024/10

FTLD-FETおよびALS-FUSにおけるFUSとTAF15の局在

大谷 麗子, 横山 敬士, 木村 朴, 河上 緒, 大島 健一, 吉田 眞理, 陸 雄一, 井上 貴美子, 村山 繁雄, 別宮 豪一, 長谷川 一子, 川浪 文, 野中 隆, 長谷川 成人

Dementia Japan　Vol. 38　No. 4　p. 723-723　2024/10

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.

Diana Arseni, Takashi Nonaka, Max H Jacobsen, Alexey G Murzin, Laura Cracco, Sew Y Peak-Chew, Holly J Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya, Yuko Saito, Shigeo Murayama, Changiz Geula, Ruben Vidal, Kathy L Newell, Marsel Mesulam, Bernardino Ghetti, Masato Hasegawa, Benjamin Ryskeldi-Falcon

Nature　Vol. 634　No. 8034　p. 662-668　2024/10　Research paper (scientific journal)

An Autopsy Case of Myotonic Dystrophy Type 1 With Pancreatic Intraductal Papillary Mucinous Neoplasm

Keisuke Nonaka, Akira Arakawa, Manato Hara, Akiko Komatsu, Takuya Nagasaka, Toshio Kumasaka, Seiya Kamino, Hirofumi Rokutan, Yuuki Shichi, Shigeo Murayama, Kazutomi Kanemaru, Chihiro Jubishi, Shutaro Futami, Toshiyuki Ishiwata, Yuko Saito, Tomio Arai, Kazumasa Harada, Joji Ishikawa

Cureus　2024/09/26　Research paper (scientific journal)

An autopsy case of MM1‐type sporadic Creutzfeldt–Jakob disease with long survival of 7 years

Aya Kawanami, Akira Arakawa, Tomoyasu Matsubara, Masanobu Miyashita, Yuichi Miyagi, Kazuko Hasegawa, Shigeo Murayama, Saburo Yagishita, Yuko Saito

Neurology and Clinical Neuroscience　2024/09/11　Research paper (scientific journal)

A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease

Mitsuaki Kashiwagi, Goichi Beck, Mika Kanuka, Yoshifumi Arai, Kaeko Tanaka, Chika Tatsuzawa, Yumiko Koga, Yuki C. Saito, Marina Takagi, Yo Oishi, Masanori Sakaguchi, Kousuke Baba, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masashi Yanagisawa, Shigeo Murayama, Takeshi Sakurai, Kazuya Sakai, Yoshimi Nakagawa, Masahiko Watanabe, Hideki Mochizuki, Yu Hayashi

Cell　2024/09　Research paper (scientific journal)

Case report: The histopathological analyses of two myelin oligodendrocyte glycoprotein antibody-associated diseases with a distinctive linear radiating gadolinium enhancement on MRI

Mikito Shimizu, Goichi Beck, Shigeo Murayama, Taku Hoshi, Hiroyuki Sumikura, Kyoko Higashida, Isao Fukasaka, Yuki Shimada, Nozomi Nagashima, Tomohiro Fujioka, Naoki Hatayama, Tatsusada Okuno, Hideki Mochizuki, Manabu Sakaguchi

Frontiers in Immunology　Vol. 15　2024/08/29　Research paper (scientific journal)

シェーグレン症候群に合併し、広範な白質脳症を呈したMOG抗体関連疾患の1例

前田 健一郎, 門脇 淳, 木村 康義, 別宮 豪一, 審良 太郎, 糸田川 英里, 村山 繁雄, 望月 秀樹

臨床神経学　Vol. 64　No. 8　p. 607-607　2024/08

CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis

Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Yohei Okubo, Takashi Sakurai, Taku Amo, Ikuko Aiba, Yufuko Saito, Yuko Saito, Shigeo Murayama, Naoki Atsuta, Ryoichi Nakamura, Genki Tohnai, Yuishin Izumi, Mitsuya Morita, Asako Tamura, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Toru Yamashita, Jun Sone, Ryuji Kaji, Gen Sobue, Yuzuru Imai, Nobutaka Hattori

PNAS Nexus　Vol. 3　No. 8　2024/07/30　Research paper (scientific journal)

Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.

Keita Sakurai, Aya M Tokumaru, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Yuichi Hayashi, Takayoshi Shimohata, Shigeo Murayama, Yasushi Iwasaki, Toshiki Uchihara, Motoko Sakai, Ichiro Yabe, Satoshi Tanikawa, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Harutoshi Fujimura, Kentaro Hayashi, Keizo Sugaya, Kazuko Hasegawa, Terunori Sano, Masaki Takao, Osamu Yokota, Tomoko Miki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Jiro Idezuka, Yasuko Toyoshima, Masato Kanazawa, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Akatsuki Kubota, Tatsushi Toda, Kenji Nakashima, Ikuko Aiba

Neuroradiology　2024/07/22　Research paper (scientific journal)

Integrated Spatial Multi-Omics Study of Postmortem Brains of Alzheimer’s Disease

Yumiko Toyama, Takashi Nirasawa, Maho Morishima, Yuko Saito, Kazuhiro Irie, Shigeo Murayama, Masaya Ikegawa

ACTA HISTOCHEMICA ET CYTOCHEMICA　Vol. 57　No. 3　p. 119-130　2024/06/28　Research paper (scientific journal)

Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson's disease.

Toshiki Tezuka, Mayu Ishiguro, Daisuke Taniguchi, Ehoto Osogaguchi, Kahori Shiba-Fukushima, Jun Ogata, Ryota Ishii, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Taro Matsui, Kenichi Kaida, Manabu Funayama, Kenya Nishioka, Fumihisa Kumazawa, Tomoyasu Matsubara, Hitoshi Tsuda, Yuko Saito, Shigeo Murayama, Yuzuru Imai, Nobutaka Hattori

Neurobiology of disease　Vol. 199　p. 106571-106571　2024/06/18　Research paper (scientific journal)

Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy.

Tomoyasu Matsubara, Kenji Ishii, Yoko Saito, Aya Midori Tokumaru, Akira Arakawa, Manato Hara, Masanori Kurihara, Renpei Sengoku, Kazutomi Kanemaru, Atsushi Iwata, Tomio Arai, Akinori Miyashita, Takeshi Ikeuchi, Masato Hasegawa, Shigeo Murayama, Yuko Saito

Acta neuropathologica communications　Vol. 12　No. 1　p. 98-98　2024/06/17

Successful treatment with reduced oral steroid dosage in an 81‐year‐old woman with statin‐induced anti‐<scp>HMGCR</scp> immune‐mediated necrotizing myopathy

Soichiro Kondo, Masanori Kurihara, Mana Higashihara, Manato Hara, Yasushi Nishina, Rika Iwakiri, Shigeo Murayama, Yuko Saito, Atsushi Iwata

Geriatrics &amp; Gerontology International　2024/06/11　Research paper (scientific journal)

An autopsy case of type A <scp>FTLD‐TDP</scp> with a <scp>GRN</scp> mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently

Takafumi Tomenaga, Shinobu Minatani, Hiroto Namba, Akitoshi Takeda, Takahito Yoshizaki, Joji Kawabe, Nazere Keyoumu, Hiroyuki Morino, Makoto Higuchi, Tomoyasu Matsubara, Hiroyuki Hatsuta, Masato Hasegawa, Shigeo Murayama, Yoshiaki Itoh

Neuropathology　2024/05/07　Research paper (scientific journal)

Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case.

Akira Arakawa, Ryoji Goto, Mana Higashihara, Yuko Hiroyoshi, Ayako Shioya, Manato Hara, Makoto Orita, Tomoyasu Matsubara, Renpei Sengoku, Masashi Kameyama, Aya M Tokumaru, Masato Hasegawa, Tatsushi Toda, Atsushi Iwata, Shigeo Murayama, Yuko Saito

Neuropathology : official journal of the Japanese Society of Neuropathology　2024/04/01

Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer's disease and other neurodegenerative diseases.

Masanori Kurihara, Tomoyasu Matsubara, Satoru Morimoto, Akira Arakawa, Kensuke Ohse, Kazutomi Kanemaru, Atsushi Iwata, Shigeo Murayama, Yuko Saito

Acta neuropathologica communications　Vol. 12　No. 1　p. 48-48　2024/03/27　Research paper (scientific journal)

Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, Michael W. Weiner, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Beau Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Rachelle S. Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo-Morrell, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Cynthia Hunt, Kathleen Tingus, Ellen Woo, Daniel H. S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T.-Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Takashi Asada, Hiroyuki Arai, Morihiro Sugishita, Hiroshi Matsuda, Noriko Sato, Hajime Sato, Kengo Ito, Teruhiko Kachi, Kenji Toba, Michio Senda, Kenji Ishii, Shun Shimohama, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Chiyoko Takanami, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Mikio Shoji, Etsuro Matsubara, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Shuichi Ono, Yoshihiro Takai, Satoshi Takahashi, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Kuniko Ueno, Hiromi Sakashita, Kuniko Watanabe, Makoto Sasaki, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Yuichi Sato, Masayuki Takeda, Koichiro Sera, Kazunori Terasaki, Toshiaki Sasaki, Yoshihiro Saitoh, Shoko Goto, Ken Nagata, Tetsuya Maeda, Yasushi Kondoh, Takashi Yamazaki, Daiki Takano, Mio Miyata, Hiromi Komatsu, Mayumi Watanabe, Tomomi Sinoda, Rena Muraoka, Kayoko Kikuchi, Hitomi Ito, Aki Sato, Toshibumi Kinoshita, Hideyo Toyoshima, Kaoru Sato, Shigeki Sugawara, Isao Ito, Fumiko Kumagai, Katsutoshi Furukawa, Masaaki Waragai, Naoki Tomita, Mari Ootsuki, Katsumi Sugawara, Satomi Sugawara, Nobuyuki Okamura, Shunji Mugikura, Atsushi Umetsu, Takanori Murata, Tatsuo Nagasaka, Yukitsuka Kudo, Manabu Tashiro, Shoichi Watanuki, Masatoyo Nishizawa, Takayoshi Tokutake, Saeri Ishikawa, Emiko Kishida, Nozomi Sato, Mieko Hagiwara, Kumi Yamanaka, Takeyuki Watanabe, Taeko Takasugi, Shoichi Inagawa, Kenichi Naito, Masanori Awaji, Tsutomu Kanazawa, Kouiti Okamoto, Masaki Ikeda, Yuiti Tasiro, Syunn Nagamine, Sathiko Kurose, Tsuneo Yamazaki, Shiori Katsuyama, Sayuri Fukushima, Etsuko Koya, Makoto Amanuma, Kouiti Ujita, Kazuhiro Kishi, Kazuhisa Tuda, Noboru Oriuti, Katsuyoshi Mizukami, Tetsuaki Arai, Etsuko Nakajima, Katsumi Miyamoto, Tomoya Kobayashi, Saori Itoya, Jun Ookubo, Toshiya Akatsu, Yoshiko Anzai, Junya Ikegaki, Yuuichi Katou, Kaori Kimura, Hajime Saitou, Kazuya Shinoda, Satoka Someya, Hiroko Taguchi, Kazuya Tashiro, Masaya Tanaka, Tatsuya Nemoto, Ryou Wakabayashi, Daisuke Watanabe, Kousaku Saotome, Ryou Kuchii, Harumasa Takano, Tetsuya Suhara, Hitoshi Shinoto, Hitoshi Shimada, Makoto Higuchi, Takaaki Mori, Hiroshi Ito, Takayuki Obata, Yoshiko Fukushima, Kazuko Suzuki, Izumi Izumida, Katsuyuki Tanimoto, Takahiro Shiraishi, Hitoshi Shinotoh, Junko Shiba, Hiroaki Yano, Miki Satake, Aimi Nakui, Yae Ebihara, Tomomi Hasegawa, Yasumasa Yoshiyama, Mami Kato, Yuki Ogata, Hiroyuki Fujikawa, Nobuo Araki, Yoshihiko Nakazato, Takahiro Sasaki, Tomokazu Shimadu, Kimiko Yoshimaru, Etsuko Imabayashi, Asako Yasuda, Keiko Ozawa, Etuko Yamamoto, Natsumi Nakamata, Noriko Miyauchi, Rieko Hashimoto, Taishi Unezawa, Takafumi Ichikawa, Hiroki Hayashi, Masakazu Yamagishi, Tunemichi Mihara, Masaya Hirano, Shinichi Watanabe, Junichiro Fukuhara, Hajime Matsudo, Nobuyuki Saito, Atsushi Iwata, Hisatomo Kowa, Toshihiro Hayashi, Ryoko Ihara, Toji Miyagawa, Mizuho Yoshida, Yuri Koide, Eriko Samura, Kurumi Fujii, Kaori Watanabe, Nagae Orihara, Toshimitsu Momose, Miwako Takahashi, Takuya Arai, Yoshiki Kojima, Akira Kunimatsu, Harushi Mori, Masami Goto, Takeo Sarashina, Syuichi Uzuki, Seiji Katou, Yoshiharu Sekine, Yukihiro Takauchi, Chiine Kagami, Kazutomi Kanemaru, Yasushi Nishina, Maria Sakaibara, Yumiko Okazaki, Rieko Okada, Maki Obata, Masaki Takao, Yuko Iwata, Mizuho Minami, Yasuko Hanabusa, Hanae Shingyouji, Kyoko Tottori, Aya Tokumaru, Makoto Ichinose, Kazuya Kume, Syunsuke Kahashi, Kunimasa Arima, Shin Tanaka, Yuko Nagahusa, Masuhiro Sakata, Mitsutoshi Okazaki, Maki Yamada, Tadashi Tukamoto, Tiine Kodama, Tomoko Takeuchi, Keiichiro Ozawa, Yoshiko Kawaji, Kyouko Tottori, Yasuhiro Nakata, Satoshi Sawada, Makoto Mimatsu, Daisuke Nakkamura, Takeshi Tamaru, Shunichirou Horiuchi, Heii Arai, Tsuneyoshi Ota, Aiko Kodaka, Yuko Tagata, Tomoko Nakada, Eizo Iseki, Kiyoshi Sato, Hiroshige Fujishiro, Norio Murayama, Masaru Suzuki, Satoshi Kimura, Masanobu Takahashi, Haruo Hanyu, Hirofumi Sakurai, Takahiko Umahara, Hidekazu Kanetaka, Kaori Arashino, Mikako Murakami, Ai Kito, Seiko Miyagi, Kaori Doi, Kazuyoshi Sasaki, Mineo Yamazaki, Akiko Ishiwata, Yasushi Arai, Akane Nogami, Sumiko Fukuda, Koichi Kozaki, Yukiko Yamada, Sayaka Kimura, Ayako Machida, Kuninori Kobayashi, Hidehiro Mizusawa, Nobuo Sanjo, Mutsufusa Watanabe, Takuya Ohkubo, Hiromi Utashiro, Yukiko Matsumoto, Kumiko Hagiya, Yoshiko Miyama, Hitoshi Shibuya, Isamu Ohashi, Akira Toriihara, Takako Shinozaki, Haruko Hiraki, Shinichi Ohtani, Toshifumi Matsui, Tomomi Toyama, Hideki Sakurai, Kumiko Sugiura, Yu Hayasaka, Hirofumi Taguchi, Shizuo Hatashita, Akari Imuta, Akiko Matsudo, Daichi Wakebe, Hideki Hayakawa, Mitsuhiro Ono, Takayoshi Ohara, Yukihiko Washimi, Yutaka Arahata, Akinori Takeda, Akiko Yamaoka, Masashi Tsujimoto, Takiko Kawai, Ai Honda, Yoko Konagaya, Hideyuki Hattori, Kenji Yoshiyama, Rina Miura, Takashi Sakurai, Miura Hisayuki, Hidetoshi Endou, Syousuke Satake, Young Jae Hong, Katsunari Iwai, Masaki Suenaga, Sumiko Morita, Kengo Itou, Takashi Kato, Ken Fujiwara, Rikio Katou, Mariko Koyama, Naohiko Fukaya, Akira Tsuji, Hitomi Shimizu, Hiroyuki Fujisawa, Tomoko Nakazawa, Satoshi Koyama, Takanori Sakata, Masahito Yamada, Mitsuhiro Yoshita, Miharu Samuraki, Kenjiro Ono, Moeko Shinohara, Yuki Soshi, Kozue Niwa, Chiaki Doumoto, Mariko Hata, Miyuki Matsushita, Mai Tsukiyama, Nozomi Takeda, Sachiko Yonezawa, Ichiro Matsunari, Osamu Matsui, Fumiaki Ueda, Yasuji Ryu, Masanobu Sakamoto, Yasuomi Ouchi, Yumiko Fujita, Madoka Chita, Rika Majima, Hiromi Tsubota, Umeo Shirasawa, Masashi Sugimori, Wataru Ariya, Yuuzou Hagiwara, Yasuo Tanizaki, Hidenao Fukuyama, Shizuko Tanaka-Urayama, Shin-Ichi Urayama, Ryosuke Takahashi, Kengo Uemura, Hajime Takechi, Chihiro Namiki, Takeshi Kihara, Hiroshi Yamauchi, Emiko Maeda, Natsu Saito, Shiho Satomi, Konomi Kabata, Tomohisa Okada, Koichi Ishizu, Shigeto Kawase, Satoshi Fukumoto, Masanori Nakagawa, Masaki Kondo, Fumitoshi Niwa, Toshiki Mizuno, Yoko Oishi, Mariko Yamazaki, Daisuke Yamaguchi, Takahiko Tokuda, Kyoko Ito, Yoku Asano, Chizuru Hamaguchi, Kei Yamada, Chio Okuyama, Kentaro Akazawa, Shigenori Matsushima, Takamasa Matsuo, Toshiaki Nakagawa, Takeshi Nii, Takuji Nishida, Kuniaki Kiuchi, Masami Fukusumi, Hideyuki Watanabe, Toshiaki Taoka, Akihiro Nogi, Masatoshi Takeda, Toshihisa Tanaka, Hiroaki Kazui, Takashi Kudo, Masayasu Okochi, Takashi Morihara, Shinji Tagami, Masahiko Takaya, Tamiki Wada, Mikiko Yokokoji, Hiromichi Sugiyama, Daisuke Yamamoto, Keiko Nomura, Mutsumi Tomioka, Naoyuki Sato, Noriyuki Hayashi, Shuko Takeda, Eiichi Uchida, Yoshiyuki Ikeda, Mineto Murakami, Takami Miki, Hiroyuki Shimada, Suzuka Ataka, Akitoshi Takeda, Yuki Iwamoto, Motokatsu Kanemoto, Jun Takeuchi, Rie Azuma, Naomi Tagawa, Junko Masao, Yuka Matsumoto, Yuko Kikukawa, Hisako Fujii, Junko Matsumura, Susumu Shiomi, Joji Kawabe, Yoshihiro Shimonishi, Mitsuji Higashida, Tomohiro Sahara, Takashi Yamanaga, Yukio Miki, Shinichi Sakamoto, Hiroyuki Tsushima, Kiyoshi Maeda, Yasuji Yamamoto, Kazuo Sakai, Haruhiko Oda, Yoshihiko Tahara, Toshio Kawamata, Taichi Akisaki, Mizuho Adachi, Masako Kuranaga, Sachi Takegawa, Seishi Terada, Yuki Kishimoto, Naoya Takeda, Nao Imai, Mayumi Yabe, Reiko Wada, Takeshi Ishihara, Hajime Honda, Osamu Yokota, Kentaro Ida, Daigo Anami, Seiji Inoue, Toshi Matsushita, Shinsuke Hiramatsu, Hiromi Tonbara, Reiko Yamamoto, Kenji Nakashima, Kenji Wada-Isoe, Saori Yamasaki, Eijiro Yamashita, Yu Nakamura, Ichiro Ishikawa, Sonoko Danjo, Tomomi Shinohara, Yuka Kashimoto, Miyuki Ueno, Yoshihiro Nishiyama, Yuka Yamamoto, Narihide Kimura, Kazuo Ogawa, Yasuhiro Sasakawa, Takashi Ishimori, Yukito Maeda, Tatsuo Yamada, Shinji Ouma, Aika Fukuhara-Kaneumi, Nami Sakamoto, Rie Nagao, Kengo Yoshimitsu, Yasuo Kuwabara, Ryuji Nakamuta, Minoru Tanaka, Manabu Ikeda, Yuusuke Yatabe, Mamoru Hashimoto, Keiichirou Kaneda, Kazuki Honda, Naoko Ichimi, Mariko Morinaga, Miyako Noda, Fumi Akatuka, Mika Kitajima, Toshinori Hirai, Shinya Shiraishi, Naoji Amano, Shinsuke Washizuka, Tetsuya Hagiwara, Yatsuka Okada, Tomomi Ogihara, Toru Takahashi, Shin Inuzuka, Nobuhiro Sugiyama, Takehiko Yasaki, Minori Kitayama, Tomonori Owa, Akiko Ryokawa, Rie Takeuchi, Satoe Goto, Keiko Yamauchi, Mie Ito, Tomoki Kaneko, Hitoshi Ueda, Shuichi Ikeda, Ban Mihara, Hirofumi Kubo, Akiko Takano, Gou Yasui, Masami Akuzawa, Kaori Yamaguchi, Toshinari Odawara, Naomi Oota, Megumi Shimamura, Mikiko Sugiyama, Atsushi Watanabe, Shigeo Takebayashi, Yoshigazu Hayakawa, Mitsuhiro Idegawa, Noriko Toya, Kazunari Ishii

Alzheimer's Research &amp; Therapy　Vol. 16　No. 1　2024/02/27　Research paper (scientific journal)

発症から緩やかな経過を経て死亡し,病理解剖にて左優位の意味性認知症の確定診断に至った1例

宮本 勝哉, 繁信 和恵, 森 康治, 佐竹 祐人, 山下 里佳, 別宮 豪一, 村山 繁雄, 池田 学

精神神経学雑誌　Vol. 126　No. 2　p. 147-147　2024/02

Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis.

Hiroshi Takigawa, Ritsuko Hanajima, Ikuko Aiba, Takayoshi Shimohata, Takahiko Tokuda, Mitsuya Morita, Osamu Onodera, Shigeo Murayama, Kazuko Hasegawa, Aya M Tokumaru, Hisanori Kowa, Masato Kanazawa, Tameto Naoi, Kenji Nakashima, Takeshi Ikeuchi

Clinical parkinsonism & related disorders　Vol. 11　p. 100279-100279　2024　Research paper (scientific journal)

Prevention of amyloid β fibril deposition on the synaptic membrane in the precuneus by ganglioside nanocluster-targeting inhibitors

Erika Miyamoto, Hideki Hayashi, Shigeo Murayama, Katsuhiko Yanagisawa, Toshinori Sato, Teruhiko Matsubara

RSC Chemical Biology　Vol. 5　No. 5　p. 459-466　2024　Research paper (scientific journal)

Seed‐competent, high‐molecular‐weight Aβ species is abundantly extracted in the cerebrovasculature and meninges in Alzheimer’s disease

Hirokazu Uchigami, Mayu Kashiwagi‐Hakozaki, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Tatsushi Toda, Tadafumi Hashimoto, Takeshi Iwatsubo

Alzheimer's & Dementia　Vol. 19　2023/12/01

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis

Go Sato, Yuya Shirai, Shinichi Namba, Ryuya Edahiro, Kyuto Sonehara, Tsuyoshi Hata, Mamoru Uemura, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Koichi Matsuda, Yuichiro Doki, Hidetoshi Eguchi, Yukinori Okada

Nature Communications　Vol. 14　No. 1　2023/12　Research paper (scientific journal)

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects

Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, David D. Conti, Nao Otomo, Zsofia Kote-Jarai, Hiroyuki Suetsugu, Rosalind A. Eeles, Yoshinao Koike, Keiko Hikino, Soichiro Yoshino, Kohei Tomizuka, Momoko Horikoshi, Kaoru Ito, Yuji Uchio, Yukihide Momozawa, Michiaki Kubo, Akihide Masumoto, Akiko Nagai, Daisuke Obata, Hiroki Yamaguchi, Kaori Muto, Kazuhisa Takahashi, Ken Yamaji, Kozo Yoshimori, Masahiko Higashiyama, Nobuaki Sinozaki, Satoshi Asai, Satoshi Nagayama, Shigeo Murayama, Shiro Minami, Takao Suzuki, Takayuki Morisaki, Wataru Obara, Yasuo Takahashi, Yoichi Furukawa, Yoshinori Murakami, Yuji Yamanashi, Yukihiro Koretsune, Yoichiro Kamatani, Koichi Matsuda, Christopher A. Haiman, Shiro Ikegawa, Hidewaki Nakagawa, Chikashi Terao

Nature Communications　Vol. 14　No. 1　2023/12　Research paper (scientific journal)

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, Edward J. Saunders, Fei Chen, Rohini Janivara, Burcu F. Darst, Xin Sheng, Yili Xu, Alisha J. Chou, Sara Benlloch, Tokhir Dadaev, Mark N. Brook, Anna Plym, Ali Sahimi, Thomas J. Hoffman, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Triin Laisk, Jéssica Figuerêdo, Kenneth Muir, Shuji Ito, Xiaoxi Liu, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Yuji Uchio, Michiaki Kubo, Yoichiro Kamatani, Artitaya Lophatananon, Peggy Wan, Caroline Andrews, Adriana Lori, Parichoy P. Choudhury, Johanna Schleutker, Teuvo L.J. Tammela, Csilla Sipeky, Anssi Auvinen, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Borge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Stig E. Bojesen, Andreas Røder, Hein V. Stroomberg, Jyotsna Batra, Suzanne Chambers, Lisa Horvath, Judith A. Clements, Wayne Tilly, Gail P. Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordstrom, Nora Pashayan, Alison M. Dunning, Maya Ghoussaini, Ruth C. Travis, Tim J. Key, Elio Riboli, Jong Y. Park, Thomas A. Sellers, Hui Yi Lin, Demetrius Albanes, Stephanie Weinstein

Nature Genetics　Vol. 55　No. 12　p. 2065-2074　2023/12　Research paper (scientific journal)

An autopsy case of variably protease-sensitive prionopathy with Met/Met homogeneity at codon 129.

Akiko Uchino, Yuko Saito, Saori Oonuma, Shigeo Murayama, Saburo Yagishita, Tetsuyuki Kitamoto, Kazuko Hasegawa

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 43　No. 6　p. 486-495　2023/12　Research paper (scientific journal)

An autopsy case of diffuse atypical argyrophilic grain disease (AGD) with presenile onset and three-year course of motor and cognitive impairment.

Kimiko Inoue, Satoko Sugase, Takashi Naka, Takeshi Ikeuchi, Shigeo Murayama, Harutoshi Fujimura

Neuropathology : official journal of the Japanese Society of Neuropathology　2023/11/07　Research paper (scientific journal)

Successful treatment of seronegative immune‐mediated necrotizing myopathy developing during pregnancy: A case report and literature review

Yuto Hayashi, Tatsuhiko Ozono, Goichi Beck, Yuki Yonenobu, Rika Yamashita, Kensuke Ikenaka, Tatsusada Okuno, Shigeo Murayama, Hideki Mochizuki

Neurology and Clinical Neuroscience　2023/10/30　Research paper (scientific journal)

免疫グロブリン療法を導入したFOSMNの一例

小比賀 俊介, 濱本 曉子, 安食 孝洋, 山下 里佳, 杉山 慎太郎, 木下 允, 別宮 豪一, 角田 渓太, 村山 繁雄, 望月 秀樹

臨床神経学　Vol. 63　No. 10　p. 687-687　2023/10

小脳・脳幹部優位のHIV関連進行性多巣性白質脳症を呈し呼吸不全で死亡した51歳男性例

山上 圭, 松原 知康, 山崎 博輝, 藤田 浩司, 原田 雅史, 中道 一生, 齊藤 祐子, 村山 繁雄, 和泉 唯信

NEUROINFECTION　Vol. 28　No. 2　p. 126-126　2023/10

日本における常染色体劣性遺伝性脊髄小脳変性症8型の臨床、遺伝、病理学的研究(A clinical, genetic, and pathological study of autosomal recessive spinocerebellar ataxia-8 in Japan)

Mitsutake Akihiko, Kawai Mizuho, Arakawa Akira, Kakumoto Toshiyuki, Matsukawa Takashi, Shirota Yuichiro, Sakuishi Kaori, Mitsui Jun, Yogo Makiko, Suzuki Masahiko, Hattori Nobutaka, Ishiura Hiroyuki, Murayama Shigeo, Tsuji Shoji, Toda Tatsushi

臨床神経学　Vol. 63　No. Suppl.　p. S335-S335　2023/09

Distinct tau folds initiate templated seeding and alter the post-translational modification profile

Airi Tarutani, Fuyuki Kametani, Marina Tahira, Yuko Saito, Mari Yoshida, Andrew C Robinson, David M A Mann, Shigeo Murayama, Taisuke Tomita, Masato Hasegawa

Brain　Vol. 146　No. 12　p. 4988-4999　2023/08/10　Research paper (scientific journal)

A heterozygous splicing variant IVS9-7A &gt; T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy

Kohji Mori, Kazue Shigenobu, Goichi Beck, Ryota Uozumi, Yuto Satake, Maki Suzuki, Shizuko Kondo, Shiho Gotoh, Yuki Yonenobu, Makiko Kawai, Yuki Suzuki, Yuko Saito, Eiichi Morii, Masato Hasegawa, Hideki Mochizuki, Shigeo Murayama, Manabu Ikeda

Acta Neuropathologica Communications　Vol. 11　No. 1　p. 130-130　2023/08/10　Research paper (scientific journal)

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model

Hirotaka Watanabe, Rei Murakami, Kazuya Tsumagari, Satoru Morimoto, Tadafumi Hashimoto, Kent Imaizumi, Iki Sonn, Kaoru Yamada, Yuko Saito, Shigeo Murayama, Takeshi Iwatsubo, Hideyuki Okano

Stem Cell Reports　Vol. 18　No. 9　p. 1854-1869　2023/08　Research paper (scientific journal)

Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.

Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew C Robinson, David M A Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H W Scheres, Masato Hasegawa

FEBS open bio　Vol. 13　No. 8　p. 1394-1404　2023/08　Research paper (scientific journal)

Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis

Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada

Cell Reports Medicine　Vol. 4　No. 7　2023/07/18　Research paper (scientific journal)

Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

Shohei Kojima, Satoshi Koyama, Mirei Ka, Yuka Saito, Erica H. Parrish, Mikiko Endo, Sadaaki Takata, Misaki Mizukoshi, Keiko Hikino, Atsushi Takeda, Asami F. Gelinas, Steven M. Heaton, Rie Koide, Anselmo J. Kamada, Michiya Noguchi, Michiaki Hamada, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Yoichiro Kamatani, Yasuhiro Murakawa, Kazuyoshi Ishigaki, Yukio Nakamura, Kaoru Ito, Chikashi Terao, Yukihide Momozawa, Nicholas F. Parrish

Nature Genetics　Vol. 55　No. 6　p. 939-951　2023/06　Research paper (scientific journal)

Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.

Tomoyasu Matsubara, Shigeo Murayama, Tadashi Tsukamoto, Terunori Sano, Masashi Mizutani, Zen-Ichi Tanei, Yuji Takahashi, Masaki Takao, Yuko Saito

Journal of neurology　Vol. 270　No. 10　p. 5090-5093　2023/05/29

RNA interference in late-stage hereditary transthyretin amyloidosis: a clinicopathological study

Goichi Beck, Yuki Yonenobu, Makiko Kawai, Kensuke Ikenaka, Fusako Sera, Tatsuhiko Ozono, Yuki Shimada, Rika Yamashita, Yasushi Sakata, Eiichi Morii, Tsuneaki Yoshinaga, Yukio Ando, Shigeo Murayama, Hideki Mochizuki

Journal of Neurology　Vol. 270　No. 9　p. 4544-4548　2023/05/08

病理解剖を行った乳児型Tay-Sachs病の8歳女児例

森地 振一郎, 山田 侑子, 渡邊 由祐, 中澤 はる香, 林 佳奈子, 高松 朋子, 春日 晃子, 竹下 美佳, 森下 那月美, 呉 宗憲, 石田 悠, 小穴 信吾, 村山 繁雄, 黒田 雅彦, 山中 岳

脳と発達　Vol. 55　No. Suppl.　p. S431-S431　2023/05

Far-field potential of the compound muscle action potential as a reliable marker in amyotrophic lateral sclerosis.

Mana Higashihara, Hiroki Yamazaki, Yuishin Izumi, Masahito Kobayashi, Hiroyuki Nodera, Chizuko Oishi, Atsushi Iwata, Shigeo Murayama, Ryuji Kaji, Masahiro Sonoo

Muscle & nerve　Vol. 68　No. 3　p. 257-263　2023/04/22　Research paper (scientific journal)

Bilateral tonic-clonic seizure and focal cortical hyperexcitability in familial Creutzfeldt-Jakob disease with E200K mutation of the prion protein.

Norihiko Kawaguchi, Atsuko Motoda, Tatsuhiro Terada, Naotaka Usui, Kiyohito Terada, Tomoyasu Matsubara, Katsuya Sato, Tetsuyuki Kitamoto, Shigeo Murayama, Tomokazu Obi

Epileptic disorders : international epilepsy journal with videotape　Vol. 25　No. 3　p. 397-405　2023/03/20

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

Acta neuropathologica　Vol. 145　No. 5　p. 573-595　2023/03/20　Research paper (scientific journal)

Correlations between cerebrospinal fluid homovanillic acid and dopamine transporter SPECT in degenerative parkinsonian syndromes

Ryoji Goto, Masanori Kurihara, Masashi Kameyama, Hiroki Komatsu, Masashi Higashino, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Tomoyasu Matsubara, Kazutomi Kanemaru, Yuko Saito, Shigeo Murayama, Atsushi Iwata

Journal of Neural Transmission　Vol. 130　No. 4　p. 513-520　2023/03/04　Research paper (scientific journal)

Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy

Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo Murayama, Hideki Mochizuki

Neuropathology　Vol. 43　No. 5　p. 351-361　2023/01/26　Research paper (scientific journal)

Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease.

Masanori Kurihara, Tatsuo Mano, Fumihiro Eto, Ikuko Yao, Kenichiro Sato, Gaku Ohtomo, Taro Bannai, Shota Shibata, Hiroyuki Ishiura, Masako Ikemura, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Mitsutoshi Setou, Atsushi Iwata

Neurobiology of disease　Vol. 177　p. 105989-105989　2023/01/05　Research paper (scientific journal)

An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau

Goichi Beck, Rika Yamashita, Kansuke Kido, Kensuke Ikenaka, Tomoya Chiba, Yuki Yonenobu, Yuko Saito, Eiichi Morii, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki

Neuropathology　Vol. 43　No. 4　p. 326-332　2023/01/02　Research paper (other academic)

Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome.

Ikuko Aiba, Yuichi Hayashi, Takayoshi Shimohata, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Aya M Tokumaru, Keita Sakurai, Shigeo Murayama, Kazuko Hasegawa, Toshiki Uchihara, Yasuko Toyoshima, Yufuko Saito, Ichiro Yabe, Satoshi Tanikawa, Keizo Sugaya, Kentaro Hayashi, Terunori Sano, Masaki Takao, Motoko Sakai, Harutoshi Fujimura, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Osamu Yokota, Tomoko Miki, Yasushi Iwasaki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Masaharu Tanaka, Jiro Idezuka, Masato Kanazawa, Kenju Aoki, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Eiichiro Mukai, Akatsuki Kubota, Tatsushi Toda, Kenji Nakashima

Brain communications　Vol. 5　No. 6　2023　Research paper (scientific journal)

CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease

Masanori Kurihara, Hiroki Komatsu, Renpei Sengoku, Mari Shibukawa, Satoru Morimoto, Tomoyasu Matsubara, Akira Arakawa, Makoto Orita, Kenji Ishibashi, Akihiko Mitsutake, Shota Shibata, Hiroyuki Ishiura, Kaori Adachi, Kensuke Ohse, Keiko Hatano, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Aya Midori Tokumaru, Kenji Ishii, Yuko Saito, Shigeo Murayama, Kazutomi Kanemaru, Atsushi Iwata

Neurology　Vol. 100　No. 10　p. 10.1212/WNL.0000000000201647-10.1212/WNL.0000000000201647　2022/12/14　Research paper (scientific journal)

Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis.

Shuuichi Mori, Shigeaki Suzuki, Tetsuro Konishi, Naoki Kawaguchi, Masahiko Kishi, Satoshi Kuwabara, Kei Ishizuchi, Heying Zhou, Futoshi Shibasaki, Hiroki Tsumoto, Takuya Omura, Yuri Miura, Seijiro Mori, Mana Higashihara, Shigeo Murayama, Kazuhiro Shigemoto

Experimental neurology　Vol. 361　p. 114300-114300　2022/12/13　Research paper (scientific journal)

急性の頭痛と左片麻痺で発症した神経核内封入体病の60歳女性例

古川 裕一, 神林 隆道, 松倉 清司, 近藤 あむろ, 小林 俊輔, 松原 知恭, 齊藤 祐子, 村山 繁雄, 光武 明彦, 石浦 浩之, 任 久美, 大場 洋, 園生 雅弘

臨床神経学　Vol. 62　No. 12　p. 972-972　2022/12

Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions

Hongsun Park, Tomoyuki Yamanaka, Yumiko Toyama, Atsushi Fujita, Hiroshi Doi, Takashi Nirasawa, Shigeo Murayama, Naomichi Matsumoto, Tomomi Shimogori, Masaya Ikegawa, Matti J. Haltia, Nobuyuki Nukina

Acta Neuropathologica Communications　Vol. 10　No. 1　2022/12　Research paper (scientific journal)

An autopsied case report of spastic paraplegia with thin corpus callosum carrying a novel mutation in the SPG11 gene: widespread degeneration with eosinophilic inclusions

Mika Hayakawa, Tomoyasu Matsubara, Yoko Mochizuki, Chisen Takeuchi, Motoyuki Minamitani, Masayuki Imai, Kenjiro Kosaki, Tomio Arai, Shigeo Murayama

BMC Neurology　Vol. 22　No. 1　2022/12　Research paper (scientific journal)

Structures of α-synuclein filaments from human brains with Lewy pathology

Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G. Murzin, Holly J. Garringer, Patrick W. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T. Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H. W. Scheres, Michel Goedert

Nature　Vol. 610　No. 7933　p. 791-795　2022/10/27　Research paper (scientific journal)

An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection.

Ryoji Goto, Haruka Kawakami, Yurino Horiuchi, Ayaka Chikada, Tsutomu Yasuda, Tetsuya Suzuki, Yusuke Miyazato, Masahiro Ishikane, Yuya Kishino, Hideki Miyazaki, Toru Igari, Harutaka Katano, Tadaki Suzuki, Shigeo Murayama, Noritoshi Arai

Internal medicine (Tokyo, Japan)　Vol. 61　No. 22　p. 3439-3444　2022/09/06

Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.

Masanori Sawamura, Hirotaka Onoe, Hideo Tsukada, Kaoru Isa, Hodaka Yamakado, Shinya Okuda, Masashi Ikuno, Yusuke Hatanaka, Shigeo Murayama, Norihito Uemura, Tadashi Isa, Ryosuke Takahashi

Movement disorders : official journal of the Movement Disorder Society　Vol. 37　No. 10　p. 2033-2044　2022/08/21　Research paper (scientific journal)

Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber density in elderly individuals

Atsuko Motoda, Tomoyasu Matsubara, Zen-ichi Tanei, Yasuhiro Sakashita, Mikihiro Yamazaki, Ito Kawakami, Renpei Sengoku, Tomio Arai, Hirofumi Maruyama, Yuko Saito, Shigeo Murayama

NEUROPATHOLOGY　Vol. 43　No. 2　p. 129-134　2022/08　Research paper (scientific journal)

Correction to: Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito, Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama, Masato Hasegawa

Acta neuropathologica　Vol. 144　No. 1　p. 165-165　2022/07　Research paper (scientific journal)

Phosphorylated alpha-synuclein in Iba1-positive macrophages in the skin of patients with Parkinson's disease.

Hideki Oizumi, Kenshi Yamasaki, Hiroyoshi Suzuki, Saki Ohshiro, Yuko Saito, Shigeo Murayama, Yoko Sugimura, Takafumi Hasegawa, Kohji Fukunaga, Atsushi Takeda

Annals of clinical and translational neurology　2022/06/24　Research paper (scientific journal)

Genetic analysis of right heart structure and function in 40,000 people

James P. Pirruccello, Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Samuel F. Friedman, Marcus D.R. Klarqvist, Mark D. Chaffin, Lu Chen Weng, Jonathan W. Cunningham, Shaan Khurshid, Carolina Roselli, Honghuang Lin, Satoshi Koyama, Kaoru Ito, Yoichiro Kamatani, Issei Komuro, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Mutu, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Sean J. Jurgens, Emelia J. Benjamin, Puneet Batra, Pradeep Natarajan, Kenney Ng, Udo Hoffmann, Steven A. Lubitz, Jennifer E. Ho, Mark E. Lindsay, Anthony A. Philippakis, Patrick T. Ellinor

Nature Genetics　Vol. 54　No. 6　p. 792-803　2022/06　Research paper (scientific journal)

Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito, Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama, Masato Hasegawa

Acta neuropathologica　Vol. 143　No. 6　p. 613-640　2022/06　Research paper (scientific journal)

<scp>TDP</scp> ‐43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease

Rika Yamashita, Goichi Beck, Yuki Yonenobu, Kimiko Inoue, Akihiko Mitsutake, Hiroyuki Ishiura, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki

Movement Disorders　2022/05/09　Research paper (scientific journal)

Impact of Seizure Recurrence on 1-Year Functional Outcome and Mortality in Patients With Poststroke Epilepsy.

Hajime Yoshimura, Tomotaka Tanaka, Kazuki Fukuma, Soichiro Matsubara, Rie Motoyama, Masahiro Mizobuchi, Takayuki Matsuki, Yasuhiro Manabe, Junichiro Suzuki, Katsuya Kobayashi, Akihiro Shimotake, Kunihiro Nishimura, Daisuke Onozuka, Michi Kawamoto, Masatoshi Koga, Kazunori Toyoda, Shigeo Murayama, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda, Masafumi Ihara

Neurology　Vol. 99　No. 4　2022/05/04　Research paper (scientific journal)

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

Omer Weissbrod, Masahiro Kanai, Huwenbo Shi, Steven Gazal, Wouter J. Peyrot, Amit V. Khera, Yukinori Okada, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Alicia R. Martin, Hilary K. Finucane, Alkes L. Price

Nature Genetics　Vol. 54　No. 4　p. 450-458　2022/04　Research paper (scientific journal)

Unique Lewy pathology in myotonic dystrophy type 1.

Terunori Sano, Tomoya Kawazoe, Ayako Shioya, Madoka Mori-Yoshimura, Yasushi Oya, Kazushi Maruo, Ichizo Nishino, Mikio Hoshino, Shigeo Murayama, Yuko Saito

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 42　No. 2　p. 104-116　2022/04　Research paper (scientific journal)

An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms.

Goichi Beck, Kazue Shigenobu, Koto Ukon, Rika Yamashita, Yuki Yonenobu, Eiichi Morii, Masato Hasegawa, Manabu Ikeda, Shigeo Murayama, Hideki Mochizuki

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 42　No. 2　p. 147-154　2022/04　Research paper (other academic)

Age-dependent formation of TMEM106B amyloid filaments in human brains.

Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors H W Scheres

Nature　Vol. 605　No. 7909　p. 310-314　2022/03/28　Research paper (scientific journal)

Autopsy Validation of the Diagnostic Accuracy of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease.

Tomoyasu Matsubara, Masashi Kameyama, Noriko Tanaka, Renpei Sengoku, Makoto Orita, Ko Furuta, Atsushi Iwata, Tomio Arai, Hirofumi Maruyama, Yuko Saito, Shigeo Murayama

Neurology　Vol. 98　No. 16　2022/03/07　Research paper (scientific journal)

Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer

Keiko Hikino, Masaru Koido, Nao Otomo, Kohei Tomizuka, Shiro Ikegawa, Koichi Matsuda, Yukihide Momozawa, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Taisei Mushiroda, Chikashi Terao

Journal of Human Genetics　Vol. 67　No. 3　p. 149-156　2022/03　Research paper (scientific journal)

Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki

bioRxiv　2022/02/10　Research paper (scientific journal)

Spinal muscular atrophy type 2 patient who survived 61 years: an autopsy case report.

Misaki Yamadera, Toshio Saito, Masakazu Shinohara, Hisahide Nishio, Shigeo Murayama, Harutoshi Fujimura

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 42　No. 2　p. 141-146　2022/02/10

Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)n.

Hanako Aoki, Miwa Higashi, Michi Okita, Noboru Ando, Shigeo Murayama, Kinya Ishikawa, Takanori Yokota

Cerebellum (London, England)　Vol. 22　No. 1　p. 70-84　2022/01/27　Research paper (scientific journal)

piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis

Rehab F. Abdelhamid, Kotaro Ogawa, Goichi Beck, Kensuke Ikenaka, Eriko Takeuchi, Yoshiaki Yasumizu, Jyunki Jinno, Yasuyoshi Kimura, Kousuke Baba, Yoshitaka Nagai, Yukinori Okada, Yuko Saito, Shigeo Murayama, Hideki Mochizuki, Seiichi Nagano

Molecular Neurobiology　Vol. 59　No. 3　p. 1693-1705　2022/01/11　Research paper (scientific journal)

Interictal epileptiform discharges as a predictive biomarker for recurrence of poststroke epilepsy.

Soichiro Abe, Tomotaka Tanaka, Kazuki Fukuma, Soichiro Matsubara, Rie Motoyama, Masahiro Mizobuchi, Hajime Yoshimura, Takayuki Matsuki, Yasuhiro Manabe, Junichiro Suzuki, Hiroyuki Ishiyama, Maya Tojima, Katsuya Kobayashi, Akihiro Shimotake, Kunihiro Nishimura, Masatoshi Koga, Kazunori Toyoda, Shigeo Murayama, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda, Masafumi Ihara

Brain communications　Vol. 4　No. 6　2022　Research paper (scientific journal)

Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis

Tomoya Wadayama, Mikito Shimizu, Ikko Kimura, Kousuke Baba, Goichi Beck, Seiichi Nagano, Ryo Morita, Hidenori Nakagawa, Michinori Shirano, Tetsushi Goto, Kazumi Norose, Kenji Hikosaka, Shigeo Murayama, Hideki Mochizuki

Internal Medicine　Vol. 61　No. 17　p. 2661-2666　2022

Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients

Yuuki Fujiwara, Chihana Kabuta, Terunori Sano, Shigeo Murayama, Yuko Saito, Tomohiro Kabuta

Neurochemistry International　Vol. 152　p. 105243-105243　2022/01　Research paper (scientific journal)

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

Qingbo S. Wang, David R. Kelley, Jacob Ulirsch, Masahiro Kanai, Shuvom Sadhuka, Ran Cui, Carlos Albors, Nathan Cheng, Yukinori Okada, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Francois Aguet, Kristin G. Ardlie, Daniel G. MacArthur, Hilary K. Finucane

Nature Communications　Vol. 12　No. 1　2021/12　Research paper (scientific journal)

Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases.

Yasuhiro Sakashita, Tomoyasu Matsubara, Tadayuki Takata, Zen-Ichi Tanei, Atsuko Motoda, Mikihiro Yamazaki, Ito Kawakami, Renpei Sengoku, Yuko Saito, Tomio Arai, Masahito Yamada, Shigeo Murayama

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 41　No. 6　p. 476-483　2021/12

Distinct phosphorylation profiles of tau in brains of patients with different tauopathies

Nastaran Samimi, Govinda Sharma, Taeko Kimura, Tomoyasu Matsubara, Anni Huo, Kurumi Chiba, Yuko Saito, Shigeo Murayama, Hiroyasu Akatsu, Yoshio Hashizume, Masato Hasegawa, Mojtaba Farjam, Koorosh Shahpasand, Kanae Ando, Shin-ichi Hisanaga

Neurobiology of Aging　Vol. 108　p. 72-79　2021/12　Research paper (scientific journal)

Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

Taisuke Kato, Ri-Ichiroh Manabe, Hironaka Igarashi, Fuyuki Kametani, Sachiko Hirokawa, Yumi Sekine, Natsumi Fujita, Satoshi Saito, Yusuke Kawashima, Yuya Hatano, Shoichiro Ando, Hiroaki Nozaki, Akihiro Sugai, Masahiro Uemura, Masaki Fukunaga, Toshiya Sato, Akihide Koyama, Rie Saito, Atsushi Sugie, Yasuko Toyoshima, Hirotoshi Kawata, Shigeo Murayama, Masaki Matsumoto, Akiyoshi Kakita, Masato Hasegawa, Masafumi Ihara, Masato Kanazawa, Masatoyo Nishizawa, Shoji Tsuji, Osamu Onodera

The Journal of clinical investigation　Vol. 131　No. 22　2021/11/15　Research paper (scientific journal)

Structure-based classification of tauopathies

Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, Mike van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hidetomo Tanaka, Akiyoshi Kakita, Takeshi Ikeuchi, Andrew C. Robinson, David M. A. Mann, Gabor G. Kovacs, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

Nature　Vol. 598　No. 7880　p. 359-363　2021/10/14　Research paper (scientific journal)

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.

Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E Bianchi, Hitoshi Okazawa

Communications biology　Vol. 4　No. 1　p. 1175-1175　2021/10/11　Research paper (scientific journal)

A cross-population atlas of genetic associations for 220 human phenotypes

Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Kaoru Ito, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada

Nature Genetics　Vol. 53　No. 10　p. 1415-1424　2021/10　Research paper (scientific journal)

"Burnt-out" progressive multifocal leukoencephalopathy in idiopathic CD4+ lymphocytopenia.

Tatsuya Fukumoto, Yasuhiro Sakashita, Fumiaki Katada, Ryoko Takeuchi, Ryosuke Miyamoto, Yuishin Izumi, Susumu Sato, Hidehiro Shibayama, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Shigeo Murayama, Toshio Fukutake

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 41　No. 6　p. 484-488　2021/09/30

Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.

Keisuke Komaki, Tetsuya Takano, Yutaka Sato, Akiko Asada, Shikito Ikeda, Kaoru Yamada, Ran Wei, Anni Huo, Aoi Fukuchi, Taro Saito, Kanae Ando, Shigeo Murayama, Wataru Araki, Fuyuki Kametani, Masato Hasegawa, Takeshi Iwatsubo, Mineko Tomomura, Mitsunori Fukuda, Shin-Ichi Hisanaga

Journal of biochemistry　2021/09/15　Research paper (scientific journal)

Antiseizure medications for post-stroke epilepsy: A real-world prospective cohort study.

Tomotaka Tanaka, Kazuki Fukuma, Soichiro Abe, Soichiro Matsubara, Rie Motoyama, Masahiro Mizobuchi, Hajime Yoshimura, Takayuki Matsuki, Yasuhiro Manabe, Junichiro Suzuki, Shuhei Ikeda, Naruhiko Kamogawa, Hiroyuki Ishiyama, Katsuya Kobayashi, Akihiro Shimotake, Kunihiro Nishimura, Daisuke Onozuka, Masatoshi Koga, Kazunori Toyoda, Shigeo Murayama, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda, Masafumi Ihara

Brain and behavior　Vol. 11　No. 9　2021/09　Research paper (scientific journal)

An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia

Ryohei Watanabe, Ito Kawakami, Takeshi Ikeuchi, Shigeo Murayama, Tetsuaki Arai, Haruhiko Akiyama, Mitsumoto Onaya, Masato Hasegawa

eNeurologicalSci　Vol. 24　p. 100363-100363　2021/09　Research paper (scientific journal)

Neuropathy/intranuclear inclusion bodies in oculopharyngodistal myopathy: A case report.

Tomoyasu Matsubara, Yuko Saito, Takashi Kurashige, Mana Higashihara, Fumio Hasegawa, Masashi Ogasawara, Aritoshi Iida, Ichizo Nishino, Tadashi Adachi, Akatsuki Kubota, Shigeo Murayama

eNeurologicalSci　Vol. 24　p. 100348-100348　2021/09　Research paper (scientific journal)

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.

Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa

Communications biology　Vol. 4　No. 1　p. 961-961　2021/08/12　Research paper (scientific journal)

ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease.

Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sato

Journal of neuropathology and experimental neurology　Vol. 80　No. 7　p. 652-662　2021/08/11　Research paper (scientific journal)

Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain.

Naoki Watanabe, Masaki Nakano, Yachiyo Mitsuishi, Norikazu Hara, Tatsuo Mano, Atsushi Iwata, Shigeo Murayama, Toshiharu Suzuki, Takeshi Ikeuchi, Masaki Nishimura

Human molecular genetics　Vol. 31　No. 1　p. 122-132　2021/08/10　Research paper (scientific journal)

Soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for differential diagnosis of mild cognitive impairment.

Wataru Araki, Kazutomi Kanemaru, Kotaro Hattori, Tadashi Tsukamoto, Yuko Saito, Sumiko Yoshida, Harumasa Takano, Masuhiro Sakata, Yuma Yokoi, Yoshie Omachi, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Hisateru Tachimori, Shigeo Murayama, Hidehiro Mizusawa

Aging clinical and experimental research　Vol. 34　No. 2　p. 341-347　2021/07/20　Research paper (scientific journal)

Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus

Tomoki T. Mitani, Goichi Beck, Kansuke Kido, Rika Yamashita, Yuki Yonenobu, Takuya Ogawa, Chizu Saeki, Tatsusada Okuno, Seiichi Nagano, Eiichi Morii, Masato Hasegawa, Yuko Saito, Shigeo Murayama, Hideki Mochizuki

Neuropathology　Vol. 41　No. 4　p. 324-331　2021/07/04

An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke.

Takaya Kitano, Yumiko Hori, Shuhei Okazaki, Yuki Shimada, Takanori Iwamoto, Hideaki Kanki, Shintaro Sugiyama, Tsutomu Sasaki, Hajime Nakamura, Naoki Oyama, Taku Hoshi, Goichi Beck, Hiroki Takai, Shunji Matsubara, Hiroya Mizuno, Hirotake Nishimura, Ryo Tamaki, Junichi Iida, Jiro Iba, Masaaki Uno, Haruhiko Kishima, Hiroaki Fushimi, Satoshi Hattori, Shigeo Murayama, Eiichi Morii, Manabu Sakaguchi, Yoshiki Yagita, Takeshi Shimazu, Hideki Mochizuki, Kenichi Todo

Thrombosis and haemostasis　Vol. 122　No. 3　p. 415-426　2021/06/02　Research paper (scientific journal)

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Seyedeh M. Zekavat, Shu Hong Lin, Alexander G. Bick, Aoxing Liu, Kaavya Paruchuri, Chen Wang, Md Mesbah Uddin, Yixuan Ye, Zhaolong Yu, Xiaoxi Liu, Yoichiro Kamatani, Romit Bhattacharya, James P. Pirruccello, Akhil Pampana, Po Ru Loh, Puja Kohli, Steven A. McCarroll, Krzysztof Kiryluk, Benjamin Neale, Iuliana Ionita-Laza, Eric A. Engels, Derek W. Brown, Jordan W. Smoller, Robert Green, Elizabeth W. Karlson, Matthew Lebo, Patrick T. Ellinor, Scott T. Weiss, Mark J. Daly, Satoshi Koyama, Kaoru Ito, Yukihide Momozawa, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Sinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Aarno Palotie, Adam Ziemann, Adele Mitchell, Adriana Huertas-Vazquez, Aino Salminen, Airi Jussila, Aki Havulinna, Alex Mackay, Ali Abbasi, Amanda Elliott, Amy Cole, Anastasia Shcherban, Anders Mälarstig, Andrea Ganna, Andrey Loboda, Anna Podgornaia, Anne Lehtonen, Anne Pitkäranta, Anne Remes, Annika Auranen, Antti Hakanen, Antti Palomäki, Anu Jalanko, Anu Loukola, Aparna Chhibber, Apinya Lertratanakul, Arto Lehisto, Arto Mannermaa, Åsa Hedman, Audrey Chu, Aviv Madar, Awaisa Ghazal, Benjamin Challis, Benjamin Sun, Beryl Cummings, Bridget Riley-Gillis, Caroline Fox, Chia Yen Chen, Clarence Wang, Clement Chatelain, Daniel Gordin, Danjuma Quarless, Danny Oh, David Choy, David Close

Nature Medicine　Vol. 27　No. 6　p. 1012-1024　2021/06　Research paper (scientific journal)

An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP43 proteinopathy

Tomoyasu Matsubara, Yuishin Izumi, Masaya Oda, Masatoshi Takahashi, Hirofumi Maruyama, Ryosuke Miyamoto, Chigusa Watanabe, Yoshiro Tachiyama, Hiroyuki Morino, Hideshi Kawakami, Yuko Saito, Shigeo Murayama

NEUROPATHOLOGY　Vol. 41　No. 2　p. 118-126　2021/04

Case report of anorexia nervosa showing periventricular gliosis at autopsy

Kentaro Umeda, Ito Kawakami, Kenji Ikeda, Zen-ichi Tanei, Tomoyasu Matsubara, Shigeo Murayama, Yuki Murahashi, Kazuhiro Niizato, Kenichi Oshima, Shuji Iritani

NEUROPATHOLOGY　Vol. 41　No. 2　p. 127-132　2021/04

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

Sofia Lövestam, Manuel Schweighauser, Tomoyasu Matsubara, Shigeo Murayama, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Mari Yoshida, Airi Tarutani, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres

FEBS Open Bio　Vol. 11　No. 4　p. 999-1013　2021/04　Research paper (scientific journal)

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification.

Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Andrew C Robinson, David M A Mann, Taisuke Tomita, Masato Hasegawa

Brain : a journal of neurology　Vol. 144　No. 8　p. 2333-2348　2021/03/09　Research paper (scientific journal)

Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations

Masaki Nakano, Yachiyo Mitsuishi, Lei Liu, Naoki Watanabe, Emi Hibino, Saori Hata, Takashi Saito, Takaomi C. Saido, Shigeo Murayama, Kensaku Kasuga, Takeshi Ikeuchi, Toshiharu Suzuki, Masaki Nishimura

Journal of Alzheimer's Disease　Vol. 80　No. 1　p. 159-174　2021/03/09　Research paper (scientific journal)

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka

Acta neuropathologica communications　Vol. 9　No. 1　p. 1-1　2021/01/05　Research paper (scientific journal)

Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Zen-ichi Tanei, Yuko Saito, Shinji Ito, Tomoyasu Matsubara, Atsuko Motoda, Mikihiro Yamazaki, Yasuhiro Sakashita, Ito Kawakami, Masako Ikemura, Shinya Tanaka, Renpei Sengoku, Tomio Arai, Shigeo Murayama

Acta Neuropathologica　Vol. 141　No. 1　p. 25-37　2021/01　Research paper (scientific journal)

The secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy.

Katsuya Araki, Naoto Yagi, Yuka Ikemoto, Hideki Hayakawa, Harutoshi Fujimura, Taro Moriwaki, Yoshitaka Nagai, Shigeo Murayama, Hideki Mochizuki

Scientific reports　Vol. 10　No. 1　p. 19423-19423　2020/11/10　Research paper (scientific journal)

MM2-type sporadic Creutzfeldt-Jakob disease: new diagnostic criteria for MM2-cortical type.

Tsuyoshi Hamaguchi, Nobuo Sanjo, Ryusuke Ae, Yosikazu Nakamura, Kenji Sakai, Masaki Takao, Shigeo Murayama, Yasushi Iwasaki, Katsuya Satoh, Hiroyuki Murai, Masafumi Harada, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada

Journal of neurology, neurosurgery, and psychiatry　Vol. 91　No. 11　p. 1158-1165　2020/11　Research paper (scientific journal)

Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device

Takaya Kitano, Manabu Sakaguchi, Hiroshi Yamagami, Tatsuya Ishikawa, Hatsue Ishibashi-Ueda, Kanta Tanaka, Shuhei Okazaki, Tsutomu Sasaki, Yoshinori Kadono, Masatoshi Takagaki, Takeo Nishida, Hajime Nakamura, Masanobu Yanase, Norihide Fukushima, Masayuki Shiozawa, Kazunori Toyoda, Jun C. Takahashi, Takayuki Funatsu, Bikei Ryu, Daisuke Yoshioka, Koichi Toda, Shigeo Murayama, Takakazu Kawamata, Haruhiko Kishima, Yoshiki Sawa, Hideki Mochizuki, Kenichi Todo

Journal of the Neurological Sciences　Vol. 418　p. 117142-117142　2020/11　Research paper (scientific journal)

Voxel-based morphometry focusing on medial temporal lobe structures has a limited capability to detect amyloid β, an Alzheimer's disease pathology.

Masashi Kameyama, Kenji Ishibashi, Jun Toyohara, Kei Wagatsuma, Yumi Umeda-Kameyama, Keigo Shimoji, Kazutomi Kanemaru, Shigeo Murayama, Sumito Ogawa, Aya M Tokumaru, Kenji Ishii

Aging　Vol. 12　No. 19　p. 19701-19710　2020/10/05　Research paper (scientific journal)

認知症CPC「認知症にかかわる医師のための臨床神経病理カンファレンス」 急速に運動・認知機能障害が進行し、もの忘れ外来受診後経過3年で死亡した83歳女性剖検例

金田 大太, 松原 知康, 石井 賢二, 徳丸 阿耶, 島田 斉, 佐原 成彦, 須原 哲也, 村山 繁雄, 齊藤 祐子

Dementia Japan　Vol. 34　No. 4　p. 470-470　2020/10

神経細胞特異的な転写制御機構から見える孤発性アルツハイマー病の病態

間野 かがり, 間野 達雄, 鈴木 穣, 森島 真帆, 村山 繁雄, 戸田 達史, 岩田 淳

Dementia Japan　Vol. 34　No. 4　p. 525-525　2020/10

TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons

Seiichi Nagano, Junki Jinno, Rehab F. Abdelhamid, Yinshi Jin, Megumi Shibata, Shohei Watanabe, Sachiko Hirokawa, Masatoyo Nishizawa, Kenji Sakimura, Osamu Onodera, Hironori Okada, Takashi Okada, Yuko Saito, Junko Takahashi-Fujigasaki, Shigeo Murayama, Shuji Wakatsuki, Hideki Mochizuki, Toshiyuki Araki

Acta Neuropathologica　Vol. 140　No. 5　p. 695-713　2020/08/16　Research paper (scientific journal)

DIUTHAMEを用いたアルツハイマー病(AD)脳の迅速MALDI質量分析イメージング(Rapid MALDI mass spectrometry imaging for Alzheimer's disease(AD) brain using DIUTHAME)

外山 友美子, 武笠 結天, 新谷 祈, 徳平 壮一郎, 大村 孝幸, 小谷 政弘, 田代 晃, 角田 伸人, 韮澤 崇, 村山 繁雄, 内藤 康秀, 池川 雅哉

JSBMS Letters　Vol. 45　No. Suppl.　p. 66-66　2020/08

Excess tau PET ligand retention in elderly patients with major depressive disorder.

Sho Moriguchi, Keisuke Takahata, Hitoshi Shimada, Manabu Kubota, Soichiro Kitamura, Yasuyuki Kimura, Kenji Tagai, Ryosuke Tarumi, Hajime Tabuchi, Jeffrey H Meyer, Masaru Mimura, Kazunori Kawamura, Ming-Rong Zhang, Shigeo Murayama, Tetsuya Suhara, Makoto Higuchi

Molecular psychiatry　2020/07/01　Research paper (scientific journal)

γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.

Nobuto Kakuda, Haruyasu Yamaguchi, Kohei Akazawa, Saori Hata, Toshiharu Suzuki, Hiroyuki Hatsuta, Shigeo Murayama, Satoru Funamoto, Yasuo Ihara

The American journal of pathology　Vol. 190　No. 6　p. 1323-1331　2020/06　Research paper (scientific journal)

Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic Cases

Tsuyoshi Hamaguchi, Kenji Sakai, Atsushi Kobayashi, Tetsuyuki Kitamoto, Ryusuke Ae, Yosikazu Nakamura, Nobuo Sanjo, Kimihito Arai, Mizuho Koide, Fumiaki Katada, Masafumi Harada, Hiroyuki Murai, Shigeo Murayama, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada

Emerging Infectious Diseases　Vol. 26　No. 6　p. 1140-1146　2020/06　Research paper (scientific journal)

Adult-onset biotinidase deficiency induces acutely progressing leukoencephalopathy

Goichi Beck, Daisuke Hirozawa, Keiichiro Honma, Kousuke Baba, Hisae Sumi, Eiichi Morii, Shigeo Murayama, Hideki Mochizuki

Neurology: Clinical Practice　Vol. 11　No. 3　p. 10.1212/CPJ.0000000000000862-10.1212/CPJ.0000000000000862　2020/05/29　Research paper (scientific journal)

Structures of α-synuclein filaments from multiple system atrophy.

Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goedert

Nature　Vol. 585　No. 7825　p. 464-469　2020/05/27　Research paper (scientific journal)

Meningoencephalitis caused by masked mastoiditis that was diagnosed during a follow-up in an elderly patient with diabetes mellitus: A case report.

Takuya Omura, Rie Motoyama, Yoshiaki Tamura, Keisuke Nonaka, Zen-Ichi Tanei, Kazuhiro Shigemoto, Aya Midori Tokumaru, Shigeo Murayama, Tomio Arai, Atsushi Araki

Geriatrics & gerontology international　Vol. 20　No. 5　p. 500-501　2020/05

A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy.

Makoto Hideshima, Goichi Beck, Misaki Yamadera, Yuichi Motoyama, Kensuke Ikenaka, Keita Kakuda, Hiroshi Tsuda, Seiichi Nagano, Harutoshi Fujimura, Eiichi Morii, Shigeo Murayama, Hideki Mochizuki

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 40　No. 2　p. 191-195　2020/04

An autopsy case of GM1 gangliosidosis type II in a patient who survived a long duration with artificial respiratory support.

Akiko Uchino, Makiko Nagai, Naomi Kanazawa, Masaaki Ichinoe, Nobuyuki Yanagisawa, Kaori Adachi, Eiji Nanba, Hiroyuki Ishiura, Jun Mitsui, Shoji Tsuji, Kinuko Suzuki, Shigeo Murayama, Kazutoshi Nishiyama

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 40　No. 4　p. 379-388　2020/03/27

Neuron-specific analysis of histone modifications with post-mortem brains.

Kagari Koshi-Mano, Tatsuo Mano, Maho Morishima, Shigeo Murayama, Akira Tamaoka, Shoji Tsuji, Tatsushi Toda, Atsushi Iwata

Scientific reports　Vol. 10　No. 1　p. 3767-3767　2020/02/28　Research paper (scientific journal)

Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study.

Saki Yoshinaga, Tomoyuki Yamanaka, Haruko Miyazaki, Ayami Okuzumi, Akiko Hiyama, Shigeo Murayama, Nobuyuki Nukina

Biochemical and biophysical research communications　Vol. 522　No. 3　p. 655-661　2020/02/12　Research paper (scientific journal)

Novel tau filament fold in corticobasal degeneration.

Wenjuan Zhang, Airi Tarutani, Kathy L Newell, Alexey G Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert, Sjors H W Scheres

Nature　Vol. 580　No. 7802　p. 283-287　2020/02/12　Research paper (scientific journal)

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.

Saori Hata, Anqi Hu, Yi Piao, Tadashi Nakaya, Hidenori Taru, Maho Morishima-Kawashima, Shigeo Murayama, Masaki Nishimura, Toshiharu Suzuki

Human molecular genetics　Vol. 29　No. 3　p. 382-393　2020/02/01　Research paper (scientific journal)

YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.

Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-Ichi Muramatsu, Hideyuki Okano, Elliott J Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa

Nature communications　Vol. 11　No. 1　p. 507-507　2020/01/24　Research paper (scientific journal)

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies.

Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C Robinson, David M A Mann, Masato Hasegawa

Frontiers in neuroscience　Vol. 14　p. 581936-581936　2020　Research paper (scientific journal)

Metabolic Network Topology of Alzheimer's Disease and Dementia with Lewy Bodies Generated Using Fluorodeoxyglucose Positron Emission Tomography.

Imai M, Tanaka M, Sakata M, Wagatsuma K, Tago T, Toyohara J, Sengoku R, Nishina Y, Kanemaru K, Ishibashi K, Murayama S, Ishii K

Journal of Alzheimer's disease : JAD　Vol. 73　No. 1　p. 197-207　2020　Research paper (scientific journal)

Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies.

Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwata

Brain sciences　Vol. 10　No. 1　p. 7-7　2019/12/20　Research paper (scientific journal)

Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease.

Akihiro Kawatsuki, Shin-Ya Morita, Naoki Watanabe, Emi Hibino, Yachiyo Mitsuishi, Takuma Sugi, Shigeo Murayama, Masaki Nishimura

Biochemistry and biophysics reports　Vol. 20　p. 100704-100704　2019/12　Research paper (scientific journal)

簡易な嗅覚識別試験による嗅覚障害とMIBG心筋シンチ所見の関連について

山崎 幹大, 仙石 錬平, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 59　No. Suppl.　p. S273-S273　2019/11

NeuroCPC 歩行時ふらつきと易転倒性で発症した83歳女性ブレインバンク生前同意登録例

渋川 茉莉, 仙石 錬平, 松原 知康, 石井 賢二, 徳丸 阿耶, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 59　No. Suppl.　p. S176-S176　2019/11

徳島県・広島県における筋萎縮性側索硬化症診断の実証的研究

松原 知康, 村山 繁雄, 織田 雅也, 宮本 亮介, 野寺 裕之, 瓦井 俊孝, 渡辺 千種, 齊藤 祐子, 梶 龍兒, 和泉 唯信

臨床神経学　Vol. 59　No. Suppl.　p. S359-S359　2019/11

臨床心理士職としてのコーディネーター活動報告 高齢者ブレインバンクプロジェクト

小幡 真希, 松原 知康, 仙石 錬平, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 59　No. Suppl.　p. S458-S458　2019/11

筋萎縮性側索硬化症はシヌクレイノパチーよりたこつぼ症候群を発症しやすい

和泉 唯信, 宮本 亮介, 藤田 浩司, 山本 雄貴, 垂髪 祐樹, 塚本 愛, 高松 直子, 森 敦子, 松原 知康, 織田 雅也, 西田 善彦, 野寺 裕之, 村山 繁雄, 梶 龍兒

臨床神経学　Vol. 59　No. Suppl.　p. S273-S273　2019/11

神経核内封入体病の末梢神経興奮特性

大崎 裕亮, 野寺 裕之, 山崎 博輝, 藤田 浩司, 宮本 亮介, 和泉 唯信, 村山 繁雄, 梶 龍兒

臨床神経学　Vol. 59　No. Suppl.　p. S312-S312　2019/11

ロチゴチン貼付で歩行時のふらつきが改善した起立性低血圧を伴うパーキンソン病の72歳男性例

山崎 幹大, 仙石 錬平, 金丸 和富, 村山 繁雄

神経治療学　Vol. 36　No. 6　p. S268-S268　2019/10

レビー小体型認知症におけるCSF Aβ40およびAβ42/40の検討

金丸 和富, 金丸 晶子, 仁科 裕史, 仙石 錬平, 村山 繁雄

Dementia Japan　Vol. 33　No. 4　p. 527-527　2019/10

ブレインバンク生前同意者への質的研究 家族性アルツハイマー病患者の語りの一例

小幡 真希, 松原 知康, 種井 善一, 河上 緒, 渋川 茉莉, 本山 りえ, 広吉 祐子, 仙石 錬平, 仁科 裕史, 古田 光, 新井 冨生, 金丸 和富, 村山 繁雄

Dementia Japan　Vol. 33　No. 4　p. 577-577　2019/10

ヒト死後脳におけるAPP・APOEの遺伝子発現解析

Lixin Liu, 宮下 哲典, 村上 涼太, Bin Zhu, 原 範和, 菊地 正隆, 月江 珠緒, 樋口 陽, 春日 健作, 中谷 明弘, 赤津 裕康, 柿田 明美, 村山 繁雄, 池内 健

Dementia Japan　Vol. 33　No. 4　p. 519-519　2019/10

Acute Liver Failure Associated with Influenza A Virus Infection: an Autopsy Case Report.

Keisuke Nonaka, Yoko Matsuda, Mototsune Kakizaki, Shoichiro Takakuma, Akihiko Hamamatsu, Yasuhiro Sakashita, Tomoyasu Matsubara, Shigeo Murayama, Toshiyuki Ishiwata, Noriko Yamanaka, Mitsuyo Itabashi, Takashi Takei, Noriko Nakajima, Hideki Hasegawa, Tomio Arai

Japanese journal of infectious diseases　Vol. 72　No. 5　p. 347-349　2019/09/19　Research paper (scientific journal)

ブコロームとワルファリン併用下で脳梗塞を繰り返した拡張型心筋症の39歳女性

小林 敬, 仁科 裕史, 仙石 錬平, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 59　No. 9　p. 608-608　2019/09

認知症診断におけるMRIの有用性と問題点

櫻井 圭太, 徳丸 阿耶, 村山 繁雄, 吉田 眞理, 橋詰 良夫

日本医学放射線学会秋季臨床大会抄録集　Vol. 55回　p. S405-S405　2019/09

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.

Takashi Saito, Naomi Mihira, Yukio Matsuba, Hiroki Sasaguri, Shoko Hashimoto, Sneha Narasimhan, Bin Zhang, Shigeo Murayama, Makoto Higuchi, Virginia M Y Lee, John Q Trojanowski, Takaomi C Saido

The Journal of biological chemistry　Vol. 294　No. 34　p. 12754-12765　2019/08/23　Research paper (scientific journal)

Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain

Atsuko Kubo, Shouyou Ueda, Ayaka Yamane, Satoko Wada-Kakuda, Mai Narita, Makoto Matsuyama, Akane Nomori, Akihiko Takashima, Taisuke Kato, Osamu Onodera, Motohito Goto, Mamoru Ito, Takami Tomiyama, Hiroshi Mori, Shigeo Murayama, Yasuo Ihara, Hiroaki Misonou, Tomohiro Miyasaka

The Journal of Neuroscience　Vol. 39　No. 34　p. 6781-6797　2019/08/21　Research paper (scientific journal)

死後脳研究ドナー登録者の意識 高齢者ブレインバンク生前同意登録者を対象とした質的研究

小幡 真希, 松原 知康, 種井 善一, 渋川 茉莉, 本山 りえ, 広吉 祐子, 仙石 錬平, 仁科 裕史, 古田 光, 新井 冨生, 村山 繁雄

日本心理学会大会発表論文集　Vol. 83回　p. 348-348　2019/08

Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.

Hiroyuki Ishiura, Shota Shibata, Jun Yoshimura, Yuta Suzuki, Wei Qu, Koichiro Doi, M Asem Almansour, Junko Kanda Kikuchi, Makiko Taira, Jun Mitsui, Yuji Takahashi, Yaeko Ichikawa, Tatsuo Mano, Atsushi Iwata, Yasuo Harigaya, Miho Kawabe Matsukawa, Takashi Matsukawa, Masaki Tanaka, Yuichiro Shirota, Ryo Ohtomo, Hisatomo Kowa, Hidetoshi Date, Aki Mitsue, Hiroyuki Hatsuta, Satoru Morimoto, Shigeo Murayama, Yasushi Shiio, Yuko Saito, Akihiko Mitsutake, Mizuho Kawai, Takuya Sasaki, Yusuke Sugiyama, Masashi Hamada, Gaku Ohtomo, Yasuo Terao, Yoshihiko Nakazato, Akitoshi Takeda, Yoshio Sakiyama, Yumi Umeda-Kameyama, Jun Shinmi, Katsuhisa Ogata, Yutaka Kohno, Shen-Yang Lim, Ai Huey Tan, Jun Shimizu, Jun Goto, Ichizo Nishino, Tatsushi Toda, Shinichi Morishita, Shoji Tsuji

Nature genetics　Vol. 51　No. 8　p. 1222-1232　2019/08　Research paper (scientific journal)

Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS.

Yuji Takahashi, Akiko Uchino, Ayako Shioya, Terunori Sano, Chihiro Matsumoto, Yurika Numata-Uematsu, Seiichi Nagano, Toshiyuki Araki, Shigeo Murayama, Yuko Saito

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 39　No. 4　p. 268-278　2019/08

Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report

Koji Fujita, Tomoyasu Matsubara, Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Keiko Maruyama Saladini, Toshitaka Kawarai, Hiroyuki Nodera, Fukashi Udaka, Kodai Kume, Hiroyuki Morino, Hideshi Kawakami, Masato Hasegawa, Ryuji Kaji, Shigeo Murayama, Yuishin Izumi

BMC neurology　Vol. 19　No. 1　2019/07/18　Research paper (scientific journal)

Identifying patients with neuronal intranuclear inclusion disease in Singapore using characteristic diffusion-weighted MR images.

Yu WY, Xu Z, Lee HY, Tokumaru A, Tan JMM, Ng A, Murayama S, Lim CCT

Neuroradiology　2019/07

レビー小体病理伝搬仮説の検証

村山 繁雄, 松原 知康, 仙石 錬平, 齊藤 祐子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 13回　p. 104-104　2019/07

Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site.

Tetsuro Tago, Jun Toyohara, Ryuichi Harada, Shozo Furumoto, Nubuyuki Okamura, Yukitsuka Kudo, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kenji Ishii

Annals of nuclear medicine　Vol. 33　No. 6　p. 375-382　2019/06

Disseminated varicella zoster virus infection and acute hepatitis: Autopsy-proven cases from a single institute.

Yoko Matsuda, Keisuke Nonaka, Atsuko Seki, Mototsune Kakizaki, Shoichiro Takakuma, Akihiko Hamamatsu, Tan Wang, Yuta Nakano, Tadayuki Takata, Junko Takahashi-Fujigasaki, Shigeo Murayama, Motoji Sawabe, Tomio Arai

Pathology international　Vol. 69　No. 6　p. 378-380　2019/06

Monoamine Oxidase B Binding of 18F-THK5351 to Visualize Glioblastoma and Associated Gliosis: An Autopsy-Confirmed Case.

Tago T, Toyohara J, Sengoku R, Murayama S, Ishii K

Clinical nuclear medicine　Vol. 44　No. 6　p. 507-509　2019/06　Research paper (scientific journal)

A型インフルエンザウイルス感染症に関連した急性肝不全の1剖検例

野中 敬介, 松田 陽子, 柿崎 元恒, 西村 優基, 高熊 将一朗, 松原 知康, 村山 繁雄, 中島 典子, 長谷川 秀樹, 新井 冨生

日本病理学会会誌　Vol. 108　No. 1　p. 378-378　2019/04

多発脳病変を認めたtumefactive MSの66歳女性例

日野 理美, 川上 真吾, 鈴木 葉子, 前田 伸也, 山田 美菜子, 中瀬 浩史, 種井 善一, 村山 繁雄

臨床神経学　Vol. 59　No. 4　p. 221-221　2019/04

von Recklinghausen病に関連した消化管のGISTと食道の横紋筋増生を認めた1剖検例

高熊 将一朗, 柿崎 元恒, 野中 敬介, 松田 陽子, 種井 善一, 高梨 成彦, 村山 繁雄, 新井 冨生

日本病理学会会誌　Vol. 108　No. 1　p. 486-486　2019/04

Distribution of endogenous normal tau in the mouse brain

Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akane Nomori, Satoko Wada‐Kakuda, Akihiko Takashima, Mitsuhiro Kawata, Shigeo Murayama, Yasuo Ihara, Tomohiro Miyasaka

Journal of Comparative Neurology　Vol. 527　No. 5　p. 985-998　2019/04　Research paper (scientific journal)

Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase inhibitor discontinuation: An autopsy report.

Kurihara M, Koda H, Aono H, Sugimoto I, Sakurai Y, Sano T, Saito Y, Murayama S, Mori M

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 39　No. 2　p. 147-155　2019/04

Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage.

Hiroyuki Hatsuta, Masaki Takao, Akane Nogami, Akiko Uchino, Hiroyuki Sumikura, Tadayuki Takata, Satoru Morimoto, Kazutomi Kanemaru, Tadashi Adachi, Tomio Arai, Masato Hasegawa, Shigeo Murayama

Acta neuropathologica communications　Vol. 7　No. 1　p. 49-49　2019/03/28　Research paper (scientific journal)

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.

Masaya Ikegawa, Takashi Nirasawa, Nobuto Kakuda, Tomohiro Miyasaka, Yuki Kuzuhara, Shigeo Murayama, Yasuo Ihara

Journal of visualized experiments : JoVE　No. 145　2019/03/07　Research paper (scientific journal)

東京都健康長寿医療センターにて経験した核内封入体病7例の報告

武 斯斌, 外山 琢, 青木 彩, 仙石 錬平, 村山 繁雄, 沼賀 二郎

日本眼科学会雑誌　Vol. 123　No. 臨増　p. 231-231　2019/03

CONFERENCE ROOM 比較的進行の速い認知症で診断に苦慮した76歳男性例

金丸 和富, 本山 りえ, 櫻井 圭太, 亀山 征史, 村山 繁雄, 加藤 貴行

内科　Vol. 123　No. 3　p. 457-464　2019/03

Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case.

Keisuke Nonaka, Yoko Matsuda, Mototsune Kakizaki, Shoichiro Takakuma, Tomoyasu Matsubara, Shigeo Murayama, Toshiyuki Ishiwata, Masashi Kameyama, Kazuto Ogura, Sumiko Kobayashi, Tomio Arai

Urology case reports　Vol. 23　p. 6-9　2019/03

Citrullinated histone H3 expression in anti-neutrophil cytoplasmic antibody-associated vasculitis in older Japanese autopsy patients.

Yoko Matsuda, Mitsuyo Itabashi, Yasuko Tachibana, Takahiko Sugihara, Yasuhiro Sakashita, Tomoyasu Matsubara, Shigeo Murayama, Wako Yumura, Akira Shimizu, Takashi Takei, Tomio Arai

Geriatrics & gerontology international　Vol. 19　No. 3　p. 259-264　2019/03　Research paper (scientific journal)

Amyotrophic lateral sclerosis of long clinical course clinically presenting with progressive muscular atrophy

Tomoyasu Matsubara, Masaya Oda, Tetsuya Takahashi, Chigusa Watanabe, Yoshiro Tachiyama, Hiroyuki Morino, Hideshi Kawakami, Ryuji Kaji, Hirofumi Maruyama, Shigeo Murayama, Yuishin Izumi

NEUROPATHOLOGY　Vol. 39　No. 1　p. 47-53　2019/02　Research paper (scientific journal)

Clasmatodendrosis is associated with dendritic spines and does not represent autophagic astrocyte death in influenza-associated encephalopathy.

Masaya Tachibana, Ikuko Mohri, Ikuko Hirata, Ayano Kuwada, Shihoko Kimura-Ohba, Kuriko Kagitani-Shimono, Hiroaki Fushimi, Takeshi Inoue, Masashi Shiomi, Yukio Kakuta, Makoto Takeuchi, Shigeo Murayama, Masahiro Nakayama, Keiichi Ozono, Masako Taniike

Brain & development　Vol. 41　No. 1　p. 85-95　2019/01　Research paper (scientific journal)

Two distinct prions in fatal familial insomnia and its sporadic form.

Atsuko Takeuchi, Shirou Mohri, Hideaki Kai, Akira Tamaoka, Atsushi Kobayashi, Hidehiro Mizusawa, Yasushi Iwasaki, Mari Yoshida, Hiroshi Shimizu, Shigeo Murayama, Shigetoshi Kuroda, Masanori Morita, Piero Parchi, Tetsuyuki Kitamoto

Brain communications　Vol. 1　No. 1　2019　Research paper (scientific journal)

Tau isoform expression and phosphorylation in marmoset brains

Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga S

Journal of Biological Chemistry　Vol. 294　No. 30　p. 11433-11444　2019　Research paper (scientific journal)

日本のブレインバンクおよびバイオバンクシステムを構築するために(To establish all Japan brain bank and bio- bank system)

Murayama Shigeo, Sengoku Renpeis, Matsubara Tomoyasu, Sakashita Yasuhiro, Saito Yuko

臨床神経学　Vol. 58　No. Suppl.　p. S400-S400　2018/12

Lewy小体病生検診断における顎下腺の有用性の検討

坂下 泰浩, 新井 冨生, 仙石 錬平, 齊藤 祐子, 村山 繁雄

臨床神経学　Vol. 58　No. Suppl.　p. S259-S259　2018/12

延髄外側梗塞の病巣部位と嚥下障害についての検討

加藤 貴行, 仙石 錬平, 仁科 裕史, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 58　No. Suppl.　p. S280-S280　2018/12

レビー小体型認知症における脳葉型微小出血と脳脊髄液バイオマーカーとの関連

金丸 和富, 仙石 錬平, 仁科 裕史, 村山 繁雄

臨床神経学　Vol. 58　No. Suppl.　p. S283-S283　2018/12

右半球病変で相貌失認を発症した脳梗塞例

渋川 茉莉, 仙石 錬平, 武田 克彦, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 58　No. Suppl.　p. S301-S301　2018/12

18F-THK5351 PETで錐体路に沿った集積を認めた膠芽腫の臨床病理学的考察

白石 朋敬, 仙石 錬平, 松原 知康, 石井 賢二, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 58　No. Suppl.　p. S275-S275　2018/12

進行性核上性麻痺における臨床型別臨床経過の検討 多施設共同前向きコホート研究

饗場 郁子, 池内 健, 瀧川 洋史, 徳田 隆彦, 下畑 享良, 森田 光哉, 村山 繁雄, 小野寺 理, 長谷川 一子, 古和 久典, 花島 律子, 中島 健二, JALPACコンソーシアム

臨床神経学　Vol. 58　No. Suppl.　p. S211-S211　2018/12

「大脳皮質基底核変性症(CBD)mimics」の背景病理 日本人を対象としたCBD検証研究(Background pathology of 'corticobasal degeneration(CBD) mimics': Japanese validation study of CBD)

下畑 享良, 饗場 郁子, 吉田 眞理, 豊島 靖子, 村山 繁雄, 内原 俊記, 新井 哲明, 齋藤 由扶子, 矢部 一郎, 長谷川 隆文, 齊藤 祐子, 瀧川 洋史, 長谷川 一子, 池内 健, 長谷川 成人, 小森 隆司, 若林 孝一, 徳丸 阿耶, 櫻井 圭太, 中島 健二, J-VAC study group

臨床神経学　Vol. 58　No. Suppl.　p. S239-S239　2018/12

PSP Rating Scaleによる進行性核上性麻痺の経時的変化に関する検討

瀧川 洋史, 池内 健, 饗場 郁子, 森田 光哉, 小野寺 理, 下畑 享良, 徳田 隆彦, 村山 繁雄, 長谷川 一子, 古和 久典, 花島 律子, 中島 健二, JALPACコンソーシアム

臨床神経学　Vol. 58　No. Suppl.　p. S261-S261　2018/12

Quantitative Analysis of Surface Electromyography for Pediatric Neuromuscular Disorders.

Mana Higashihara, Masahiro Sonoo, Akihiko Ishiyama, Yu Nagashima, Kohji Matsumoto, Haruo Uesugi, Madoka Mori-Yoshimura, Miho Murata, Shigeo Murayama, Hirofumi Komaki

Muscle & nerve　Vol. 58　No. 6　p. 824-827　2018/12　Research paper (scientific journal)

An Autopsy Case of Familial Neuronal Intranuclear Inclusion Disease with Dementia and Neuropathy.

Nanaka Yamaguchi, Tatsuo Mano, Ryo Ohtomo, Hiroyuki Ishiura, M Asem Almansour, Harushi Mori, Junko Kanda, Yuichiro Shirota, Kenichiro Taira, Teppei Morikawa, Masako Ikemura, Yasuo Yanagi, Shigeo Murayama, Jun Shimizu, Yasuhisa Sakurai, Shoji Tsuji, Atsushi Iwata

Internal medicine (Tokyo, Japan)　Vol. 57　No. 23　p. 3459-3462　2018/12/01

簡便な嗅覚識別試験を用いたパーキンソン病スクリーニング検査の開発

山崎 幹大, 仙石 錬平, 金丸 和富, 村山 繁雄

神経治療学　Vol. 35　No. 6　p. S255-S255　2018/11

Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.

Takeyuki Tsuchida, Tatsuo Mano, Kagari Koshi-Mano, Taro Bannai, Tomoyasu Matsubara, Satoshi Yamashita, Toshikazu Ushijima, Kenichi Nagata, Shigeo Murayama, Tatsushi Toda, Shoji Tsuji, Atsushi Iwata

Brain research　Vol. 1697　p. 59-66　2018/10/15　Research paper (scientific journal)

嗅覚障害を自覚した症例における新たな検査法「簡易嗅覚識別試験」とMIBG心筋シンチ所見の検討

山崎 幹大, 仙石 錬平, 金丸 和富, 村山 繁雄

日本自律神経学会総会プログラム・抄録集　Vol. 71回　p. 142-142　2018/10

交感神経機能亢進が疑われた球麻痺型筋萎縮性側索硬化症の一例

渋川 茉莉, 仙石 錬平, 大庭 和人, 金丸 和富, 村山 繁雄

日本自律神経学会総会プログラム・抄録集　Vol. 71回　p. 145-145　2018/10

Precision Medicineによるパーキンソン病の次世代治療ストラテジー開発

佐竹 渉, 上中 健, 鈴木 マリ, 永井 義隆, 長谷川 隆文, 川上 秀史, 渡邊 雅彦, 柏原 健一, 村山 繁雄, 玉岡 晃, 望月 秀樹, 長谷川 一子, 中島 健二, 武田 篤, 山本 光利, 村田 美穂, 服部 信孝, 戸田 達史

Dementia Japan　Vol. 32　No. 3　p. 434-434　2018/09

レビー小体型認知症における脳アミロイド血管症と脳脊髄液バイオマーカーとの関連

金丸 和富, 金丸 晶子, 仁科 裕史, 仙石 錬平, 村山 繁雄

Dementia Japan　Vol. 32　No. 3　p. 451-451　2018/09

マススペクトロメトリーの検査応用 現状と今後の課題 イメージングマススペクトロメトリーを用いたアルツハイマー病脳病理研究

池川 雅哉, 角田 伸人, 宮坂 知宏, 韮澤 崇, 村山 繁雄, 井原 康夫

臨床病理　Vol. 66　No. 9　p. 1004-1009　2018/09

日本ブレインバンクネット(JBBN)の構築とその運用

森島 真帆, 柿田 明美, 吉田 眞理, 矢部 博興, 國井 泰人, 入谷 修司, 寺田 整司, 横田 修, 大島 健一, 田中 紀子, 井上 悠輔, 村山 繁雄, 齊藤 祐子

Dementia Japan　Vol. 32　No. 3　p. 450-450　2018/09

孤発性アルツハイマー病剖検脳における神経細胞特異的ヒストン修飾解析

間野 かがり, 間野 達雄, 岩田 淳, 村山 繁雄, 戸田 達史

Dementia Japan　Vol. 32　No. 3　p. 433-433　2018/09

早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析

祖父江 顕, 遠藤 史人, 小峯 起, 村山 繁雄, 山中 宏二

Dementia Japan　Vol. 32　No. 3　p. 447-447　2018/09

「ブレインバンク」ドナー登録者の意識 アンケート調査のテキスト分析による研究

小幡 真希, 畠山 幸子, 坂下 泰浩, 元田 淳子, 山崎 幹大, 渋川 茉莉, 種井 善一, 松原 知康, 本山 りえ, 広吉 祐子, 仙石 錬平, 加藤 貴行, 仁科 裕史, 金丸 和富, 古田 光, 新井 冨生, 村山 繁雄

Dementia Japan　Vol. 32　No. 3　p. 450-450　2018/09

APOE遺伝型はAPPの遺伝子発現量に影響を及ぼすか? ヒト死後脳における検証

村上 涼太, 朱 斌, 原 範和, 菊地 正隆, 月江 珠緒, 春日 健作, 宮下 哲典, 中谷 明弘, 赤津 裕康, 柿田 明美, 村山 繁雄, 池内 健

Dementia Japan　Vol. 32　No. 3　p. 429-429　2018/09

成人発症の神経核内封入体病自験例14例の臨床的検討

針谷 康夫, 高田 忠幸, 中野 雄太, 岡 大典, 石川 大介, 水島 和幸, 村山 繁雄

Dementia Japan　Vol. 32　No. 3　p. 464-464　2018/09

パーキンソン病患者の嗅覚機能障害評価のための新たな検査法「簡易嗅覚識別試験」の検討

山崎 幹大, 仙石 錬平, 金丸 和富, 村山 繁雄

パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 12回　p. 82-82　2018/07

【画像診断医のための認知症画像診断】Alzheimer病以外の認知症のMRI

徳丸 阿耶, 下地 啓五, 亀山 征史, 村山 繁雄, 櫻井 圭太

画像診断　Vol. 38　No. 9　p. 897-911　2018/07

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology

Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi, Hitoshi Okazawa

eneuro　Vol. 5　No. 4　p. ENEURO.0217-18.2018　2018/07　Research paper (scientific journal)

[Chorea due to chronic subdural hematoma].

Tomotaka Shiraishi, Renpei Sengoku, Shigehiko Takanashi, Mari Shibukawa, Kazutomi Kanemaru, Shigeo Murayama

Rinsho shinkeigaku = Clinical neurology　Vol. 58　No. 6　p. 399-402　2018/06/27

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Qian Ren, Min Ma, Jun Yang, Risa Nonaka, Akihiro Yamaguchi, Kei-Ichi Ishikawa, Kenta Kobayashi, Shigeo Murayama, Sung Hee Hwang, Shinji Saiki, Wado Akamatsu, Nobutaka Hattori, Bruce D Hammock, Kenji Hashimoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 25　p. E5815-E5823-E5823　2018/06/19　Research paper (scientific journal)

慢性硬膜下血腫により舞踏運動を発症した86歳女性例

白石 朋敬, 仙石 錬平, 高梨 成彦, 渋川 茉莉, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 58　No. 6　p. 399-402　2018/06

Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC

Kazunori Sano, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Yasushi Iwasaki, Mari Yoshida, Shigeo Murayama, Kenichi Mishima, Noriyuki Nishida

Molecular Neurobiology　Vol. 55　No. 5　p. 3916-3930　2018/05/01　Research paper (scientific journal)

ブレインバンクプロジェクトと在宅医療

小幡 真希, 仙石 錬平, 新井 冨生, 金丸 和富, 村山 繁雄

板橋区医師会医学会誌　Vol. 22　p. 230-230　2018/05

Optineurin pathology in the spinal cord of amyotrophic lateral sclerosis/parkinsonism-dementia complex patients in Kii Peninsula, Japan.

Satoru Morimoto, Hiroyuki Hatsuta, Rie Motoyama, Yasumasa Kokubo, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, Shigeo Murayama

Brain pathology (Zurich, Switzerland)　Vol. 28　No. 3　p. 422-426　2018/05

66歳で発症し経過17年の意味性認知症、83歳男性剖検例-臨床・画像・病理

山崎 幹大, 小林 万希子, 櫻井 圭太, 川嶋 乃里子, 仙石 錬平, 村山 繁雄

臨床神経学　Vol. 58　No. 4　p. 258-258　2018/04

Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders

Masaki Nishioka, Miki Bundo, Junko Ueda, Fumiki Katsuoka, Yukuto Sato, Yoko Kuroki, Takao Ishii, Wataru Ukai, Shigeo Murayama, Eri Hashimoto, Masao Nagasaki, Jun Yasuda, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto

Psychiatry and Clinical Neurosciences　Vol. 72　No. 4　p. 280-294　2018/04/01

Background pathology of 'corticobasal degeneration (CBD) mimics' -Japanese validation study of CBD (J-VAC study)-

Shimohata, Takayoshi, Aiba, Ikuko, Yoshida, Mari, Toyoshima, Yasuko, Murayama, Shigeo, Uchihara, Toshiki, Arai, Tetsuaki, Yabe, Ichiro, Hasegawa, Takafumi, Hasegawa, Kazuko, Ikeuchi, Takeshi, Hasegawa, Masato, Komori, Takashi, Wakabayashi, Koichi, Tokumaru, Aya, Sakurai, Keita, Nakashima, Kenji

NEUROLOGY　Vol. 90　No. 15　2018/04　Research paper (scientific journal)

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.

Tarutani, A, Arai T, Murayama, S, Hisanaga, S.I, Hasegawa, M

Acta Neuropathol Commun　Vol. 6　No. 1　p. 29-29　2018/04　Research paper (scientific journal)

Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration

Akiko Uchino, Mieko Ogino, Junko Takahashi-Fujigasaki, Saori Oonuma, Naomi Kanazawa, Sabine Kajita, Masaaki Ichinoe, Masato Hasegawa, Kazutoshi Nishiyama, Shigeo Murayama

Neuropathology　Vol. 38　No. 2　p. 171-178　2018/04/01

DNA methylation level of the neprilysin promoter in Alzheimer's disease brains.

Kenichi Nagata, Tatsuo Mano, Shigeo Murayama, Takaomi C Saido, Atsushi Iwata

Neuroscience letters　Vol. 670　p. 8-13　2018/03/23　Research paper (scientific journal)

【頭部の鑑別診断のポイント】(第1章)拡散強調像 遷延する拡散強調像での高信号の鑑別

徳丸 阿耶, 櫻井 圭太, 下地 啓五, 亀山 征史, 村山 繁雄

画像診断　Vol. 38　No. 4　p. s22-s29　2018/03

Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the Kii Peninsula, Japan.

Satoru Morimoto, Hiroyuki Hatsuta, Yasumasa Kokubo, Yuta Nakano, Masato Hasegawa, Misao Yoneda, Yoshifumi Hirokawa, Shigeki Kuzuhara, Taizo Shiraishi, Shigeo Murayama

Brain pathology (Zurich, Switzerland)　Vol. 28　No. 2　p. 287-291　2018/03

An autopsy case of globular glial tauopathy presenting with clinical features of motor neuron disease with dementia and iron deposition in the motor cortex.

Hasegawa I, Takeda A, Hatsuta H, Kubo Y, Ohsawa M, Nakano Y, Ikeuchi T, Hasegawa M, Murayama S, Itoh Y

Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 38　No. 4　p. 372-379　2018/03

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers

Ye Zhao, Gayathri Perera, Junko Takahashi-Fujigasaki, Deborah C Mash, Jean Paul G Vonsattel, Akiko Uchino, Kazuko Hasegawa, R. Jeremy Nichols, Janice L Holton, Shigeo Murayama, Nicolas Dzamko, Glenda M Halliday

Brain　Vol. 141　No. 2　p. 486-495　2018/02/01　Research paper (scientific journal)

Spinocerebellar ataxia type 2 presenting with rapidly progressing muscle weakness and muscular atrophy.

Satoru Morimoto, Masaki Takao, Yasushi Nishina, Keita Sakurai, Tadashi Komiya, Kazutomi Kanemaru, Shigeo Murayama

Geriatrics & gerontology international　Vol. 18　No. 2　p. 361-364　2018/02

Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma: An autopsy study of older Japanese patients.

Yoko Matsuda, Atsuko Seki, Keisuke Nonaka, Mototsune Kakizaki, Tan Wang, Junko Aida, Naoshi Ishikawa, Yuta Nakano, Daita Kaneda, Tadayuki Takata, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kaiyo Takubo, Toshiyuki Ishiwata, Motoji Sawabe, Tomio Arai

Geriatrics & gerontology international　Vol. 18　No. 2　p. 211-215　2018/02　Research paper (scientific journal)

約7年の経過で球症状と筋力低下が緩徐に進行し、ミトコンドリア異常を伴う多発筋炎の診断に至った72歳女性例

白石 朋敬, 仙石 錬平, 仁科 裕史, 久保田 暁, 清水 潤, 園生 雅弘, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 58　No. 1　p. 59-59　2018/01

Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study.

Yuishin Izumi, Ryosuke Miyamoto, Koji Fujita, Yuki Yamamoto, Hirotsugu Yamada, Tomoyasu Matsubara, Yuki Unai, Ai Tsukamoto, Naoko Takamatsu, Hiroyuki Nodera, Shinya Hayashi, Masaya Oda, Atsuko Mori, Yoshihiko Nishida, Shunsuke Watanabe, Hirohisa Ogawa, Hisanori Uehara, Shigeo Murayama, Masataka Sata, Ryuji Kaji

Frontiers in neurology　Vol. 9　p. 1099-1099　2018　Research paper (scientific journal)

TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration

Ryo Endo, Noriko Takashima, Yoko Nekooki-Machida, Yusuke Komi, Kelvin Kai-Wan Hui, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Akira Sawa, Motomasa Tanaka

Biological Psychiatry　2018　Research paper (scientific journal)

A case of acute leukoencephalopathy induced by a combination of 5-fluorouracil and metronidazole

Tatsuya Fukumoto, Fumiaki Katada, Susumu Sato, Hidehiro Shibayama, Shigeo Murayama, Toshio Fukutake

Clinical Neurology　Vol. 58　No. 2　p. 118-123　2018

【中枢神経系の新たな疾患カテゴリーとその画像所見】高齢者tauopathy

櫻井 圭太, 徳丸 阿耶, 村山 繁雄

臨床画像　Vol. 33　No. 12　p. 1406-1417　2017/12

【高齢者診療における画像診断】高齢者の脳イメージング 認知症診断への第一歩

徳丸 阿耶, 櫻井 圭太, 下地 啓五, 亀山 征史, 村山 繁雄

臨床放射線　Vol. 62　No. 13　p. 1737-1751　2017/12

Pathologic Study of Intracranial Large Artery Atherosclerosis in 7260 Autopsy Cases

Hiroaki Kimura, Masaki Takao, Norihiro Suzuki, Kazutomi Kanemaru, Ban Mihara, Shigeo Murayama

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　Vol. 26　No. 12　p. 2821-2827　2017/12　Research paper (scientific journal)

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, Atsushi Iwata

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 45　p. E9645-E9654-E9654　2017/11/07　Research paper (scientific journal)

Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.

Nobuto Kakuda, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Satoko Wada-Kakuda, Junko Takahashi-Fujigasaki, Shigeo Murayama, Yasuo Ihara, Masaya Ikegawa

Acta neuropathologica communications　Vol. 5　No. 1　p. 73-73　2017/10/16　Research paper (scientific journal)

脳幹病変で発症後、約1ヵ月の急速な経過で亡くなった血管内大細胞型B細胞リンパ腫の81歳男性剖検例

山崎 幹大, 白石 朋敬, 仙石 錬平, 小林 万希子, 新井 冨生, 村山 繁雄

臨床神経学　Vol. 57　No. 10　p. 635-635　2017/10

レビー小体病における認知機能低下とCSFバイオマーカーとの関連

金丸 和富, 金丸 晶子, 仁科 裕史, 仙石 錬平, 村山 繁雄

Dementia Japan　Vol. 31　No. 4　p. 585-585　2017/10

認知症を呈する白質脳症 画像の観点から

徳丸 阿耶, 櫻井 圭太, 下地 啓五, 亀山 征史, 村山 繁雄, 齊藤 祐子

Dementia Japan　Vol. 31　No. 4　p. 531-531　2017/10

マススペクトロメトリーの検査応用 現状と今後の課題 イメージング質量分析法を用いたアルツハイマー病脳病理研究

池川 雅哉, 角田 伸人, 宮坂 知宏, 韮澤 崇, 藤ヶ崎 純子, 村山 繁雄, 井原 康夫

臨床病理　Vol. 65　No. 補冊　p. 073-073　2017/10

「ブレインバンク」ドナー登録者の意識 高齢遺族のグリーフケアにかかる予備的研究

小幡 真希, 松原 和康, 坂下 泰浩, 小林 万希子, 高田 忠幸, 東原 真奈, 広吉 祐子, 仙石 錬平, 仁科 裕史, 古田 光, 金丸 和富, 新井 富生, 村山 繁雄

Dementia Japan　Vol. 31　No. 4　p. 643-643　2017/10

神経細胞特異的DNAメチローム解析によるレビー小体病の新規病態の探索

土田 剛行, 坂内 太郎, 間野 達雄, 永田 健一, 山下 聡, 藤ヶ崎 純子, 村山 繁雄, 西道 隆臣, 牛島 俊和, 辻 省次, 岩田 淳

Dementia Japan　Vol. 31　No. 4　p. 572-572　2017/10

MRI diagnosis in other dementias

Aya M. Tokumaru, Yuko Saito, Shigeo Murayama, Keita Sakurai

Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias　p. 39-115　2017/08/29　Part of collection (book)

PML Nuclear Bodies Are Altered in Adult-Onset Neuronal Intranuclear Hyaline Inclusion Disease

Yuta Nakano, Junko Takahashi-Fujigasaki, Renpei Sengoku, Kazutomi Kanemaru, Tomio Arai, Takashi Kanda, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 76　No. 7　p. 585-594　2017/07　Research paper (scientific journal)

パーキンソン病の起立性低血圧 カテコラミン測定、MIBG心筋シンチを用いた検討

渋川 茉莉, 仙石 錬平, 江口 桂, 山崎 幹大, 金田 大太, 仁科 裕史, 金丸 和富, 村山 繁雄

自律神経　Vol. 54　No. 2　p. 158-158　2017/06

一側の動眼神経麻痺で発症した、感染性心内膜炎による敗血症性脳塞栓症の64歳男性

東原 真奈, 仙石 錬平, 橋爪 貴史, 高梨 成彦, 根本 佳子, 櫻井 圭太, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 57　No. 6　p. 328-328　2017/06

気腫性腎盂腎炎による敗血症で梗塞をきたした49歳女性例

三原 現, 仁科 裕史, 東原 真奈, 仙石 錬平, 金田 大太, 増田 義重, 金丸 和富, 村山 繁雄

日本内科学会関東地方会　Vol. 632回　p. 33-33　2017/05

Beyond the midbrain atrophy: wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy

Keita Sakurai, Aya M. Tokumaru, Keigo Shimoji, Shigeo Murayama, Kazutomi Kanemaru, Satoru Morimoto, Ikuko Aiba, Motoo Nakagawa, Yoshiyuki Ozawa, Masashi Shimohira, Noriyuki Matsukawa, Yoshio Hashizume, Yuta Shibamoto

NEURORADIOLOGY　Vol. 59　No. 5　p. 431-443　2017/05

発話量低下と歩行障害に髄液シャント術が著効した、アルツハイマー病理合併特発性正常圧水頭症82歳女性例

渋川 茉莉, 仙石 錬平, 高梨 成彦, 金田 大太, 藤ヶ崎 純子, 徳丸 阿耶, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 57　No. 4　p. 186-186　2017/04

Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index

Naoko Honma, Shigehira Saji, Tetuo Mikami, Noriko Yoshimura, Seijiro Mori, Yuko Saito, Shigeo Murayama, Nobuhiro Harada

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/04　Research paper (scientific journal)

【PSPとCBD-その共通点と相違点】大脳皮質基底核変性症(CBD) 画像検査

徳丸 阿耶, 櫻井 圭太, 村山 繁雄

Clinical Neuroscience　Vol. 35　No. 3　p. 306-309　2017/03

視覚性課題に示されるDLBの疾患特異性の検討 TMT、RBMT、WAIS、CDTを用いて

小幡 真希, 瀬川 千尋, 東原 真奈, 仙石 錬平, 金田 大太, 仁科 裕史, 加藤 貴行, 金丸 和富, 武田 克彦, 村山 繁雄

高次脳機能研究　Vol. 37　No. 1　p. 108-108　2017/03

LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies

Nicolas Dzamko, Amanda M. Gysbers, Rina Bandopadhyay, Marc F. Bolliger, Akiko Uchino, Ye Zhao, Masaki Takao, Sandrine Wauters, Wilma D. J. van de Berg, Junko Takahashi-Fujigasaki, R. Jeremy Nichols, Janice L. Holton, Shigeo Murayama, Glenda M. Halliday

Movement Disorders　Vol. 32　No. 3　p. 423-432　2017/03/01　Research paper (scientific journal)

認知症 認知症の画像診断 臨床、画像、病理をつなぐ意味

徳丸 阿耶, 櫻井 圭太, 下地 啓吾, 亀山 征史, 村山 繁雄, 金丸 和富, 仙石 錬平, 藤ヶ崎 純子, 中野 雄太, 齊藤 祐子

Japanese Journal of Diagnostic Imaging　Vol. 35　No. 1　p. 73-73　2017/02

Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer's disease: An autopsy-confirmed study

Satoru Morimoto, Masaki Takao, Hiroyuki Hatsuta, Yasushi Nishina, Tadashi Komiya, Renpei Sengoku, Yuta Nakano, Akiko Uchino, Hiroyuki Sumikura, Yuko Saito, Kazutomi Kanemaru, Shigeo Murayama

PLOS ONE　Vol. 12　No. 2　2017/02　Research paper (scientific journal)

Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis

Tatsuya Yamamoto, Shigeo Murayama, Masaki Takao, Tadashi Isa, Noriyuki Higo

Brain Research　Vol. 1655　p. 168-175　2017/01/15　Research paper (scientific journal)

【あらためて認知症を考える-Living Well with dementia】診断学 検査の限界と留意点を考える MRI 臨床現場での意義と課題

徳丸 阿耶, 櫻井 圭太, 下地 啓五, 村山 繁雄, 藤ヶ崎 純子, 齊藤 祐子

老年精神医学雑誌　Vol. 28　No. 増刊I　p. 91-99　2017/01

Neurologic attack and dynamic perfusion abnormality in neuronal intranuclear inclusion disease

Koji Fujita, Yusuke Osaki, Ryosuke Miyamoto, Yoshimitsu Shimatani, Takashi Abe, Hiroyuki Sumikura, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji

Neurology: Clinical Practice　Vol. 7　No. 6　p. e39-e42　2017　Research paper (scientific journal)

Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease

Marwan N. Sabbagh, Barbara Schäuble, Keshav Anand, Danielle Richards, Shigeo Murayama, Hiroyasu Akatsu, Masaki Takao, Christopher C. Rowe, Colin L. Masters, Henryk Barthel, Hermann-Josef Gertz, Oliver Peters, Natalie Rasgon, Aleksandar Jovalekic, Osama Sabri, Walter J. Schulz-Schaeffer, John Seibyl

Journal of Alzheimer's Disease　Vol. 56　No. 2　p. 441-446　2017　Research paper (scientific journal)

Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan.

Yukiko Hata, Ning Ma, Misao Yoneda, Satoru Morimoto, Hideyuki Okano, Shigeo Murayama, Shosuke Kawanishi, Shigeki Kuzuhara, Yasumasa Kokubo

Frontiers in neuroscience　Vol. 11　p. 751-751　2017　Research paper (scientific journal)

Simultaneous skin-nerve-muscle biopsy and abnormal mitochondrial inclusions in intranuclear hyaline inclusion body disease

Satoru Morimoto, Hiroyuki Hatsuta, Tadashi Komiya, Kazutomi Kanemaru, Aya Midori Tokumaru, Shigeo Murayama

JOURNAL OF THE NEUROLOGICAL SCIENCES　Vol. 372　p. 447-449　2017/01

Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer's disease

Norikazu Hara, Masataka Kikuchi, Akinori Miyashita, Hiroyuki Hatsuta, Yuko Saito, Kensaku Kasuga, Shigeo Murayama, Takeshi Ikeuchi, Ryozo Kuwano

ACTA NEUROPATHOLOGICA COMMUNICATIONS　Vol. 5　No. 1　2017/01　Research paper (scientific journal)

Excess APP O-glycosylation by GalNAc-T6 decreases A beta production

Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saito, Yuriko Tachida, Shinobu Kitazume, Hiroyuki Hatsuta, Yuri Miura, Shin-ichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya, Tamao Endo

JOURNAL OF BIOCHEMISTRY　Vol. 161　No. 1　p. 99-111　2017/01　Research paper (scientific journal)

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-Ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Kunimasa Arima, Kenji Ishii, Shigeo Murayama, Hiroshi Matsuda, Hisateru Tachimori, Yumiko M Araki, Hidehiro Mizusawa

Biomarker research　Vol. 5　p. 28-28　2017　Research paper (scientific journal)

アルツハイマー型認知症における腎機能と脳脊髄バイオマーカーとの関連

金丸 和富, 仁科 裕史, 仙石 錬平, 金田 大太, 村山 繁雄

臨床神経学　Vol. 56　No. Suppl.　p. S398-S398　2016/12

パーキンソン症候群患者におけるDAT scan、MIBGシンチと脳脊髄液5HIAAの比較

山崎 幹大, 仙石 錬平, 金田 大太, 仁科 裕史, 徳丸 阿耶, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 56　No. Suppl.　p. S449-S449　2016/12

PSP/CBDの臨床と病理 確定診断 進行性核上性麻痺PSP/皮質基底核変性症CBDの画像診断

徳丸 阿耶, 齊藤 祐子, 村山 繁雄, 藤ヶ崎 純子, 下地 啓五, 伊藤 公輝, 櫻井 圭太

臨床神経学　Vol. 56　No. Suppl.　p. S179-S179　2016/12

腕神経叢生検における電気生理学的局在診断の有用性についての検討 局所再発を伴わない乳癌の腕神経叢転移を病理診断しえた57歳女性例

東原 真奈, 時村 文秋, 中野 雄太, 松田 陽子, 櫻井 圭太, 徳丸 阿耶, 新井 冨生, 園生 雅弘, 村山 繁雄

末梢神経　Vol. 27　No. 2　p. 348-348　2016/12

特発性正常圧水頭症における脳脊髄液バイオマーカーの検討

渋川 茉莉, 仙石 錬平, 山崎 幹大, 江口 桂, 本山 りえ, 広吉 祐子, 東原 真奈, 金田 大太, 仁科 裕史, 徳丸 阿耶, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 56　No. Suppl.　p. S445-S445　2016/12

神経痛性筋萎縮症 本邦における臨床像についての検討

東原 真奈, 園生 雅弘, 今福 一郎, 福武 敏夫, 仙石 錬平, 村山 繁雄

臨床神経学　Vol. 56　No. Suppl.　p. S465-S465　2016/12

パーキンソン病(PD)の起立性低血圧(OH) カテコラミン測定、MIBG心筋シンチを用いた検討

渋川 茉莉, 仙石 錬平, 江口 桂, 山崎 幹大, 金田 大太, 仁科 裕史, 金丸 和富, 村山 繁雄

日本自律神経学会総会プログラム・抄録集　Vol. 69回　p. 93-93　2016/11

Histopathologic Analysis of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL): A Report of a New Genetically Confirmed Case and Comparison to 2 Previous Cases

Shinji Ito, Masaki Takao, Toshio Fukutake, Hiroyuki Hatsuta, Sayaka Funabe, Nobuo Ito, Yutaka Shimoe, Toshiro Niki, Imaharu Nakano, Masashi Fukayama, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 75　No. 11　p. 1020-1030　2016/11　Research paper (scientific journal)

Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients

Takatsuki Hanae, Fuse Takayuki, Nakagaki Takehiro, Mori Tsuyoshi, Mihara Ban, Takao Masaki, Iwasaki Yasushi, Yoshida Mari, Murayama Shigeo, Atarashi Ryuichiro, Nishida Noriyuki, Satoh Katsuya

EBioMedicine　Vol. 12　p. 150-155　2016/10

うつ病、糖尿病に低血糖脳症を来たした79歳女性例

石滝 公一, 江口 桂, 仙石 錬平, 金田 大太, 仁科 裕史, 金丸 和富, 村山 繁雄

日本内科学会関東地方会　Vol. 627回　p. 33-33　2016/10

高次脳機能障害、精神症状を呈しステロイドパルス療法が奏効したCerebral amyloid angiopathyの1例

仙石 錬平, 江口 桂, 山崎 幹大, 金丸 和富, 村山 繁雄

神経治療学　Vol. 33　No. 5　p. S234-S234　2016/10

アルツハイマー病における脳葉型微小出血と脳脊髄液バイオマーカー、ApoEとの関連

金丸 和富, 金丸 晶子, 仁科 裕史, 仙石 錬平, 金田 大太, 村山 繁雄, 徳丸 阿耶

Dementia Japan　Vol. 30　No. 4　p. 573-573　2016/10

イメージング質量分析法を用いたアルツハイマー病脳タンパク質の解析

池川 雅哉, 宮坂 知宏, 角田 伸人, 岩崎 了教, 韮澤 崇, 藤ヶ崎 純子, 村山 繁雄, 井原 康夫

Dementia Japan　Vol. 30　No. 4　p. 562-562　2016/10

下位腕神経叢障害を示唆する神経伝導検査所見のパターンについての検討 ルーチンNCSから、下位腕神経叢障害を見出すための試み

小野 秀子, 東原 真奈, 桜山 千恵子, 大石 知瑞子, 村山 繁雄, 時村 文秋, 園生 雅弘

臨床神経生理学　Vol. 44　No. 5　p. 444-444　2016/10

神経細胞特異的DNAメチル化解析から示されたAlzheimer病におけるDNA傷害の重要性

間野 達雄, 永田 健一, 村山 繁雄, 西道 隆臣, 辻 省次, 岩田 淳

Dementia Japan　Vol. 30　No. 4　p. 533-533　2016/10

Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion

Yoshimitsu Shimatani, Yuta Nakano, Naoko Tsuyama, Shigeo Murayama, Ryosuke Oki, Ryosuke Miyamoto, Nagahisa Murakami, Koji Fujita, Syunsuke Watanabe, Hisanori Uehara, Takashi Abe, Hiroyuki Nodera, Toshitaka Kawarai, Yuishin Izumi, Ryuji Kaji

Neuropathology　Vol. 36　No. 5　p. 456-463　2016/10/01

RT-QuIC法偽陽性2症例の臨床病理学的研究

本山 りえ, 清水 利彦, 中野 雄太, 藤ヶ崎 純子, 仙石 錬平, 佐藤 克也, 高尾 昌樹, 村山 繁雄

NEUROINFECTION　Vol. 21　No. 2　p. 232-232　2016/09

意欲低下、歩行障害で発症、大脳白質病変、long cord lesionを示し、一部ステロイドに反応が見られた63歳女性例

江口 桂, 仙石 錬平, 種井 良二, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 56　No. 9　p. 653-653　2016/09

Presence of Citrullinated Histone H3-Positive Neutrophils in Microscopic Polyangiitis from the Early Phase: An Autopsy Proven Case

Yoko Matsuda, Hideki Hamayasu, Atsuko Seki, Keisuke Nonaka, Tan Wang, Takumi Matsumoto, Yoshitomo Hamano, Hiroyuki Sumikura, Toshio Kumasaka, Shigeo Murayama, Akihiko Ishizu, Akira Shimizu, Takahiko Sugihara, Tomio Arai

PATHOLOGY INTERNATIONAL　Vol. 66　No. 8　p. 466-471　2016/08　Research paper (scientific journal)

Anti-TIF1-gamma antibody and cancer-associated myositis A clinicohistopathologic study

Ayumi Hida, Takenari Yamashita, Yuji Hosono, Manami Inoue, Kenichi Kaida, Masato Kadoya, Yusuke Miwa, Nobuyuki Yajima, Reika Maezawa, Satoko Arai, Kazuhiro Kurasawa, Kazuhiro Ito, Hiroyuki Shimada, Tomoko Iwanami, Masahiro Sonoo, Yuki Hatanaka, Shigeo Murayama, Ayumi Uchibori, Atsuro Chiba, Hitoshi Aizawa, Takayuki Momoo, Yoshiharu Nakae, Yasuhisa Sakurai, Yasushi Shiio, Hideji Hashida, Toshihiro Yoshizawa, Yoshio Sakiyama, Aya Oda, Kiyoharu Inoue, Sousuke Takeuchi, Nobue K. Iwata, Hidetoshi Date, Naoki Masuda, Takashi Mikata, Yasufumi Motoyoshi, Yoshikazu Uesaka, Meiko Hashimoto Maeda, Ran Nakashima, Shoji Tsuji, Shin Kwak, Tsuneyo Mimori, Jun Shimizu

NEUROLOGY　Vol. 87　No. 3　p. 299-308　2016/07　Research paper (scientific journal)

プリオン蛋白遺伝子M232R置換を伴ったハンチントン病の63歳男性長期観察例

仙石 錬平, 山崎 幹大, 金田 大太, 仁科 裕史, 金丸 和富, 村山 繁雄, 徳丸 阿耶

臨床神経学　Vol. 56　No. 7　p. 517-517　2016/07

拡散強調画像で皮髄境界部に高信号病変を認めたFragile X-associated tremor/ataxia syndrome(FXTAS)の64歳男性例

針谷 康夫, 佐藤 正行, 水島 和幸, 難波 栄二, 中野 雄太, 村山 繁雄

臨床神経学　Vol. 56　No. 7　p. 511-511　2016/07

Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease

Kouki Makioka, Tsuneo Yamazaki, Masamitsu Takatama, Masaki Ikeda, Shigeo Murayama, Koichi Okamoto, Yoshio Ikeda

Journal of the Neurological Sciences　Vol. 365　p. 101-107　2016/06/15　Research paper (scientific journal)

Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9

Yuta Morisaki, Mamiko Niikura, Mizuho Watanabe, Kosuke Onishi, Shogo Tanabe, Yasuhiro Moriwaki, Takashi Okuda, Shinji Ohara, Shigeo Murayama, Masaki Takao, Sae Uchida, Koji Yamanaka, Hidemi Misawa

Scientific Reports　Vol. 6　2016/06/06　Research paper (scientific journal)

皮膚生検はレビー小体病のバイオマーカーとなりうるか

仙石 錬平, 齊藤 陽子, 仁科 裕史, 池村 雅子, 齊藤 祐子, 金丸 和富, 村山 繁雄

自律神経　Vol. 53　No. 2　p. 185-186　2016/06

Impact of Training Method on the Robustness of the Visual Assessment of F-18-Florbetaben PET Scans: Results from a Phase-3 Study

John Seibyl, Ana M. Catafau, Henryk Barthel, Kenji Ishii, Christopher C. Rowe, James B. Leverenz, Bernardino Ghetti, James W. Ironside, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Santiago Bullich, Andre Mueller, Norman Koglin, Walter J. Schulz-Schaeffer, Anja Hoffmann, Marwan N. Sabbagh, Andrew W. Stephens, Osama Sabri

JOURNAL OF NUCLEAR MEDICINE　Vol. 57　No. 6　p. 900-906　2016/06　Research paper (scientific journal)

舞踏運動を発症した慢性硬膜下血腫の86歳、女性例

白石 朋敬, 仙石 錬平, 金田 大太, 江口 桂, 東原 真奈, 仁科 裕史, 金丸 和富, 村山 繁雄

日本内科学会関東地方会　Vol. 623回　p. 35-35　2016/05

Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1

Kaneyasu Nishimura, Daisuke Doi, Bumpei Samata, Shigeo Murayama, Tsuyoshi Tahara, Hirotaka Onoe, Jun Takahashi

Stem Cell Reports　Vol. 6　No. 4　p. 511-524　2016/04/12　Research paper (scientific journal)

Progressive supranuclear palsy and Parkinson's disease overlap: A clinicopathological case report

Kunihiko Araki, Hiroyuki Sumikura, Takashi Matsudaira, Akira Sugiura, Masaki Takao, Shigeo Murayama, Tomokazu Obi

NEUROPATHOLOGY　Vol. 36　No. 2　p. 187-191　2016/04

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains

Fuyuki Kametani, Tomokazu Obi, Takeo Shishido, Hiroyasu Akatsu, Shigeo Murayama, Yuko Saito, Mari Yoshida, Masato Hasegawa

Scientific Reports　Vol. 6　2016/03/16　Research paper (scientific journal)

高齢者におけるTMT part Aの検討 AD、DLB、PDの疾患別比較

小幡 真希, 瀬川 千尋, 仙石 錬平, 金田 大太, 仁科 裕史, 江口 桂, 加藤 貴行, 高尾 昌樹, 金丸 和富, 村山 繁雄

高次脳機能研究　Vol. 36　No. 1　p. 126-126　2016/03

小児神経筋疾患の診断における表面筋電図の定量解析法(CI法)の有用性 非侵襲的に神経原性疾患と筋疾患を鑑別する

東原 真奈, 園生 雅弘, 石山 昭彦, 長島 優, 上杉 春雄, 森 まどか, 村田 美穂, 村山 繁雄, 小牧 宏文

板橋区医師会医学会誌　Vol. 20　p. 118-118　2016/03

傍脊柱筋に著明な筋萎縮を認めた、vanishing bile duct syndromeに合併した筋炎の57歳女性例

宮川 晋治, 川村 廉, 下山 隆, 松本 喜弘, 谷口 洋, 羽野 寛, 内野 彰子, 村山 繁雄

臨床神経学　Vol. 56　No. 2　p. 127-127　2016/02

翼状肩甲を伴う四肢近位筋の筋力低下を呈し小脳脳幹に強い脳萎縮および末梢神経障害を認めたミトコンドリア脳筋症の45歳男性例

渋川 茉莉, 東原 真奈, 中野 雄太, 瀧口 直子, 仁科 裕史, 仙石 錬平, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 56　No. 2　p. 125-125　2016/02

Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases

Masaru Kurosawa, Gen Matsumoto, Hiroyuki Sumikura, Hiroyuki Hatsuta, Shigeo Murayama, Takashi Sakurai, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina

Neuroscience Research　Vol. 103　p. 64-70　2016/02/01

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

Sayuri Taniguchi-Watanabe, Tetsuaki Arai, Fuyuki Kametani, Takashi Nonaka, Masami Masuda-Suzukake, Airi Tarutani, Shigeo Murayama, Yuko Saito, Kunimasa Arima, Mari Yoshida, Haruhiko Akiyama, Andrew Robinson, David M. A. Mann, Takeshi Iwatsubo, Masato Hasegawa

Acta Neuropathologica　Vol. 131　No. 2　p. 267-280　2016/02/01　Research paper (scientific journal)

An autopsy case of progressive generalized muscle atrophy over 14 years due to post-polio syndrome

Ryosuke Oki, Akiko Uchino, Yuishin Izumi, Hirohisa Ogawa, Shigeo Murayama, Ryuji Kaji

Clinical Neurology　Vol. 56　No. 1　p. 12-16　2016

Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties

Atsushi Kobayashi, Yuichi Matsuura, Toru Iwaki, Yasushi Iwasaki, Mari Yoshida, Hitoshi Takahashi, Shigeo Murayama, Masaki Takao, Shinsuke Kato, Masahito Yamada, Shirou Mohri, Tetsuyuki Kitamoto

Brain Pathology　Vol. 26　No. 1　p. 95-101　2016/01/01　Research paper (scientific journal)

Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia with Lewy Bodies

Hiroyuki Hatsuta, Masaki Takao, Yuta Nakano, Akane Nogami, Akiko Uchino, Hiroyuki Sumikura, Kazutomi Kanemaru, Tomio Arai, Yoshiaki Itoh, Shigeo Murayama

JOURNAL OF PARKINSONS DISEASE　Vol. 6　No. 2　p. 325-334　2016　Research paper (scientific journal)

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

Gabor G. Kovacs, Isidro Ferrer, Lea T. Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J. Cairns, John F. Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M. Halliday, James W. Ironside, Seth Love, Ian R. Mackenzie, David G. Munoz, Melissa E. Murray, Peter T. Nelson, Hitoshi Takahashi, John Q. Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G. Beach, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Brittany N. Dugger, Mel Feany, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Kimmo J. Hatanpaa, Richard Heale, Patrick R. Hof, Monika Hofer, Tibor Hortobagyi, Kurt Jellinger, Gregory A. Jicha, Paul Ince, Julia Kofler, Enikoe Koevari, Jillian J. Kril, David M. Mann, Radoslav Matej, Ann C. McKee, Catriona McLean, Ivan Milenkovic, Thomas J. Montine, Shigeo Murayama, Edward B. Lee, Jasmin Rahimi, Roberta D. Rodriguez, Annemieke Rozemuller, Julie A. Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B. Toledo, Markus Tolnay, Juan C. Troncoso, Harry V. Vinters, Serge Weis, Stephen B. Wharton, Charles L. White, Thomas Wisniewski, John M. Woulfe, Masahito Yamada, Dennis W. Dickson

ACTA NEUROPATHOLOGICA　Vol. 131　No. 1　p. 87-102　2016/01　Research paper (scientific journal)

Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders

Yuko Saito, Ayako Shioya, Terunori Sano, Hiroyuki Sumikura, Miho Murata, Shigeo Murayama

Movement Disorders　Vol. 31　No. 1　p. 135-138　2016/01/01　Research paper (scientific journal)

The abundance of nonphosphorylated tau in mouse and human tauopathy brains revealed by the use of Phos-tag method.

Kimura, T, Hatsuta, H, Masuda-Suzukake, M, Hosokawa, M, Ishiguro, K, Akiyama, H, Murayama, S, Hasegawa, M, Hisanaga, S

Am. J. Pathol　Vol. 186　p. 398-409　2016　Research paper (scientific journal)

Enhanced phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme

Daishi Yui, Yoichiro Nishida, Tomoko Nishina, Kaoru Mogushi, Mio Tajiri, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, Takanori Yokota

PLoS ONE　Vol. 10　No. 12　2015/12/01　Research paper (scientific journal)

Lewy body diseaseの診断補助に皮膚生検はなりうる

仙石 錬平, 齊藤 陽子, 仁科 裕史, 江口 桂, 東原 真奈, 宮川 晋治, 小松 鉄平, 隅蔵 大幸, 池村 雅子, 齊藤 祐子, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 55　No. Suppl.　p. S309-S309　2015/12

Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains

Akihito Ishigami, Hirofumi Masutomi, Setsuko Handa, Megumi Nakamura, Shuuichi Nakaya, Yoshiaki Uchida, Yuko Saito, Shigeo Murayama, Byungki Jang, Yong-Chul Jeon, Eun-Kyoung Choi, Yong-Sun Kim, Yasushi Kasahara, Naoki Maruyama, Tosifusa Toda

Journal of Neuroscience Research　Vol. 93　No. 11　p. 1664-1674　2015/11/01　Research paper (scientific journal)

Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar atrophy

Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Mitsuru Sanada, Koji Fujita, Toshitaka Kawarai, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji

Neurology　Vol. 85　No. 17　p. 1522-1524　2015/10/27　Research paper (scientific journal)

Accumulation of transportin 1 in the fused in sarcomapositive neuronal inclusions in sporadic amyotrophic lateral sclerosis without FUS mutation

Tokushige Shin-ichi, Sasaki Takuya, Hatsuta Hiroyuki, Uchino Akiko, Kakuta Yukio, Shimizu Jun, Tsuji Shoji, Nakayama Takahiro, Imafuku Ichiro, Murayama Shigeo

NEUROLOGY AND CLINICAL NEUROSCIENCE　Vol. 3　No. 5　p. 194-196　2015/09

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3 beta signaling pathway

Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo, Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano

HUMAN MOLECULAR GENETICS　Vol. 24　No. 17　p. 4879-4900　2015/09　Research paper (scientific journal)

Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.

Sumikura H, Takao M, Hatsuta H, Ito S, Nakano Y, Uchino A, Nogami A, Saito Y, Mochizuki H, Murayama S

Acta neuropathologica communications　Vol. 3　2015/09　Research paper (scientific journal)

進行性の下肢筋力低下を呈した家族性低カリウム性周期性四肢麻痺の一例

下山 隆, 恩田 亜沙子, 山崎 幹大, 谷口 洋, 小川 剛, 佐々木 良元, 仙石 錬平, 村山 繁雄

臨床神経学　Vol. 55　No. 8　p. 616-616　2015/08

質量イメージング解析-基礎から応用への新展開 アルツハイマー病脳研究のための質量イメージング解析

池川 雅哉, 宮坂 知宏, 角田 伸人, 岩崎 了教, 韮澤 崇, 隅蔵 大幸, 村山 繁雄, 井原 康夫

JSBMS Letters　Vol. 40　No. Suppl.　p. 40-40　2015/08

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study.

Osama Sabri, Marwan N Sabbagh, John Seibyl, Henryk Barthel, Hiroyasu Akatsu, Yasuomi Ouchi, Kohei Senda, Shigeo Murayama, Kenji Ishii, Masaki Takao, Thomas G Beach, Christopher C Rowe, James B Leverenz, Bernardino Ghetti, James W Ironside, Ana M Catafau, Andrew W Stephens, Andre Mueller, Norman Koglin, Anja Hoffmann, Katrin Roth, Cornelia Reininger, Walter J Schulz-Schaeffer

Alzheimer's & dementia : the journal of the Alzheimer's Association　Vol. 11　No. 8　p. 964-74　2015/08　Research paper (scientific journal)

Identification of neurexophilin 3 as a novel supportive factor for survival of induced pluripotent stem cell-derived dopaminergic progenitors

Kaneyasu Nishimura, Shigeo Murayama, Jun Takahashi

Stem Cells Translational Medicine　Vol. 4　No. 8　p. 932-944　2015/07/27　Research paper (scientific journal)

神経核内封入体における急性発作は低灌流後の過灌流を伴う

大崎 裕亮, 隅蔵 大幸, 武内 俊明, 宮本 亮介, 島谷 佳光, 藤田 浩司, 村山 繁雄, 和泉 唯信, 梶 龍兒

てんかん研究　Vol. 33　No. 1　p. 164-164　2015/06

[A Case of Corticobasal Syndrome Complicated with Hypopituitarism and Hashimoto's Disease].

Satoru Morimoto, Yoshiyuki Kinbara, Makoto Terada, Tadashi Komiya, Kenji Ishii, Masaki Takao, Kazutomi Kanemaru, Shigeo Murayama

Brain and nerve = Shinkei kenkyu no shinpo　Vol. 67　No. 6　p. 759-64　2015/06

Incidence and extent of TDP-43 accumulation in aging human brain.

Uchino A, Takao M, Hatsuta H, Sumikura H, Nakano Y, Nogami A, Saito Y, Arai T, Nishiyama K, Murayama S

Acta neuropathologica communications　Vol. 3　2015/06　Research paper (scientific journal)

Neurodegenerative changes in patients with clinical history of bipolar disorders

Ayako Shioya, Yuko Saito, Kunimasa Arima, Yukio Kakuta, Takefumi Yuzuriha, Noriko Tanaka, Shigeo Murayama, Akira Tamaoka

Neuropathology　Vol. 35　No. 3　p. 245-253　2015/06/01

小児神経筋疾患における表面筋電図定量解析 Clustering Index法の導入と有用性の検討

石山 昭彦, 東原 真奈, 園生 雅弘, 長島 優, 上杉 春雄, 森 まどか, 村田 美穂, 村山 繁雄, 小牧 宏文, 佐々木 征行

脳と発達　Vol. 47　No. Suppl.　p. S278-S278　2015/05

Clinical features in Gerstmann-Straussler-Scheinker syndrome with P105L mutation

Furukawa Fumiko, Sanjo Nobuo, Higuma Maya, Kitamoto Tetsuyuki, Hizume Masaki, Nakamura Yoshikazu, Yukamoto Tadashi, Murayama Shigeo, Koshi Kagari, Matsukawa Takashi, Tsuji Shoji, Goto Jun, Yamada Masahito, Mizusawa Hidehiro, Yokota Takanori

PRION　Vol. 9　2015/04/24

Variants associated with Gaucher disease in multiple system atrophy

Jun Mitsui, Takashi Matsukawa, Hidenao Sasaki, Ichiro Yabe, Masaaki Matsushima, Alexandra Duerr, Alexis Brice, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Hiroyuki Ishiura, Tsutomu Yasuda, Hidetoshi Date, Budrul Ahsan, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yasuo Nakahara, Yoshio Momose, Yuji Takahashi, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Takamichi Hattori, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Tomoyoshi Kondo, Shigeo Murayama, Nobutaka Hattori, Mitsutoshi Yamamoto, Miho Murata, Wataru Satake, Tatsushi Toda, Alessandro Filla, Thomas Klockgether, Ullrich Wuellner, Garth Nicholson, Sid Gilman, Caroline M. Tanner, Walter A. Kukull, Mathew B. Stern, Virginia M. -Y. Lee, John Q. Trojanowski, Eliezer Masliah, Phillip A. Low, Paola Sandroni, Laurie J. Ozelius, Tatiana Foroud, Shoji Tsuji

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY　Vol. 2　No. 4　p. 417-426　2015/04　Research paper (scientific journal)

皮膚生検でLewy小体病理を確認し得たpure autonomic failure(PAF)の67歳男性例

齊藤 陽子, 仙石 錬平, 仁科 裕史, 村山 繁雄, 宮川 晋治, 井口 保之

臨床神経学　Vol. 55　No. 4　p. 286-286　2015/04

Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneus

Naoto Oikawa, Teruhiko Matsubara, Ryoto Fukuda, Hanaki Yasumori, Hiroyuki Hatsuta, Shigeo Murayama, Toshinori Sato, Akemi Suzuki, Katsuhiko Yanagisawa

PLoS ONE　Vol. 10　No. 3　2015/03/23　Research paper (scientific journal)

CONFERENCE ROOM 運動神経障害と感覚神経障害を伴う多発神経障害(ポリニューロパチー)の1例

金丸 和富, 森本 悟, 小宮 正, 飯塚 あい, 加藤 貴行, 高尾 昌樹, 新井 冨生, 仙石 錬平, 村山 繁雄, 井藤 英喜, 初田 裕幸, 東京都健康長寿医療センターCPC

内科　Vol. 115　No. 2　p. 292-300　2015/02

Simplification of the modified Gallyas method

Nobuo Kuninaka, Minato Kawaguchi, Masaru Ogawa, Ayako Sato, Kunimasa Arima, Shigeo Murayama, Yuko Saito

Neuropathology　Vol. 35　No. 1　p. 10-15　2015/02/01

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi

EMBO Molecular Medicine　Vol. 7　No. 2　p. 175-189　2015/02/01　Research paper (scientific journal)

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

Kazuhiko Tagawa, Hidenori Homma, Ayumu Saito, Kyota Fujita, Xigui Chen, Seiya Imoto, Tsutomu Oka, Hikaru Ito, Kazumi Motoki, Chisato Yoshida, Hiroyuki Hatsuta, Shigeo Murayama, Takeshi Iwatsubo, Satoru Miyano, Hitoshi Okazawa

Human Molecular Genetics　Vol. 24　No. 2　p. 540-558　2015/01/15　Research paper (scientific journal)

非典型的な臨床経過、画像・病理所見を示した神経核内封入体病の81歳女性剖検例

佐々木 拓也, 徳重 真一, 前川 理沙, 岸田 由紀子, 齊藤 祐子, 村山 繁雄, 日出山 拓人, 椎尾 康

臨床神経学　Vol. 55　No. 1　p. 64-64　2015/01

リステリア髄膜炎の79歳女性例

恒松 香名, 仁科 裕史, 増田 義重, 仙石 錬平, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 55　No. 1　p. 70-70　2015/01

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease

Maria Szaruga, Sarah Veugelen, Manasi Benurwar, Sam Lismont, Diego Sepulveda-Falla, Alberto Lleo, Natalie S. Ryan, Tammaryn Lashley, Nick C. Fox, Shigeo Murayama, Harrie Gijsen, Bart De Strooper, Lucía Chávez-Gutiérrez

Journal of Experimental Medicine　Vol. 212　No. 12　p. 2003-2013　2015　Research paper (scientific journal)

Mononeuritis multiplex due to thrombotic ischemia of primary antiphospholipid antibody syndrome without vasculitis: An autopsy case report

Masatoshi Takahashi, Fumiaki Katada, Susumu Sato, Hidehiro Shibayama, Toshio Fukutake, Shigeo Murayama

Clinical Neurology　Vol. 55　No. 12　p. 897-903　2015

The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson's syndrome

Keita Sakurai, Etsuko Imabayashi, Aya M. Tokumaru, Shin Hasebe, Shigeo Murayama, Satoru Morimoto, Kazutomi Kanemaru, Masaki Takao, Yuta Shibamoto, Noriyuki Matsukawa

NEUROIMAGE-CLINICAL　Vol. 7　p. 605-610　2015　Research paper (scientific journal)

Amyloid β accumulation assessed with 11C-pittsburgh compound B PET and postmortem neuropathology

Hiroyuki Hatsuta, Masaki Takao, Kenji Ishii, Kiichi Ishiwata, Yuko Saito, Kazutomi Kanemaru, Tomio Arai, Tetsuya Suhara, Hitoshi Shimada, Hitoshi Shinotoh, Akira Tamaoka, Shigeo Murayama

Current Alzheimer Research　Vol. 12　No. 3　p. 278-286　2015/01/01　Research paper (scientific journal)

Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases.

Nogami A, Yamazaki M, Saito Y, Hatsuta H, Sakiyama Y, Takao M, Kimura K, Murayama S

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi　Vol. 82　No. 6　p. 266-273　2015

純粋型レビー小体病の臨床病理学的特徴

仙石 錬平, 隅蔵 大幸, 初田 裕幸, 野上 茜, 内野 彰子, 高尾 昌樹, 村山 繁雄

臨床神経学　Vol. 54　No. Suppl.　p. S145-S145　2014/12

筋萎縮性側索硬化症の初期には、線維束自発電位が脱神経電位よりも多く観察される

東原 真奈, 園生 雅弘, 今福 一郎, 福武 敏夫, 畑中 裕己, 村山 繁雄

臨床神経学　Vol. 54　No. Suppl.　p. S115-S115　2014/12

Extensive cortical spongiform changes with cerebellar small amyloid plaques: The clinicopathological case of MV2K+C subtype in Creutzfeldt-Jakob disease

Kunihiko Araki, Yuta Nakano, Atsushi Kobayashi, Takashi Matsudaira, Akira Sugiura, Masaki Takao, Tetsuyuki Kitamoto, Shigeo Murayama, Tomokazu Obi

Neuropathology　Vol. 34　No. 6　p. 541-546　2014/12/01

あなたの診断は何ですか(What is your diagnosis?)

仙石 錬平, 高尾 昌樹, 村山 繁雄

Dementia Japan　Vol. 28　No. 4　p. 461-461　2014/10

臨床場面での神経心理検査とアミロイドβの関連について

小幡 真希, 佐野 保, 中野 雄太, 江口 桂, 仙石 錬平, 仁科 裕史, 加藤 貴行, 高尾 昌樹, 金丸 和富, 村山 繁雄

Dementia Japan　Vol. 28　No. 4　p. 494-494　2014/10

小児神経筋疾患の診断における表面筋電図の定量解析法(CI法)の有用性 非侵襲的に神経原性疾患と筋疾患を鑑別する

東原 真奈, 園生 雅弘, 石山 昭彦, 長島 優, 上杉 春雄, 森 まどか, 村田 美穂, 村山 繁雄, 小牧 宏文

臨床神経生理学　Vol. 42　No. 5　p. 285-285　2014/10

正常脳におけるタウの神経細胞内局在

久保 厚子, 御園生 裕明, 松田 響子, 松山 誠, 河田 光博, 初田 裕幸, 村山 繁雄, 井原 康夫, 宮坂 知宏

Dementia Japan　Vol. 28　No. 4　p. 472-472　2014/10

クリプトコッカス髄膜炎の既往があり、HAART開始から3年5ヵ月後に急速進行性の白質病変を呈した63歳男性例

永迫 友規, 中元 ふみ子, 宮川 和子, 橋本 英樹, 畠山 修司, 池村 雅子, 寺尾 安生, 村山 繁雄, 辻 省次

NEUROINFECTION　Vol. 19　No. 2　p. 163-163　2014/08

消退する多彩な神経症状を呈し、家族歴を有するサルコイドーシスの66歳女性例

藤井 悠子, 東原 真奈, 櫻井 圭太, 津山 直子, 栗原 知多流, 小宮 正, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 54　No. 8　p. 689-689　2014/08

MM2型孤発性Creutzfeldt-Jakob病の臨床的特徴について

浜口 毅, 坂井 健二, 野崎 一朗, 篠原 もえ子, 三條 伸夫, 中村 好一, 北本 哲之, 村山 繁雄, 佐藤 克也, 原田 雅史, 水澤 英洋, 山田 正仁

NEUROINFECTION　Vol. 19　No. 2　p. 209-209　2014/08

Sudden death in Parkinson's disease: A retrospective autopsy study

Hideyuki Matsumoto, Renpei Sengoku, Yuko Saito, Yukio Kakuta, Shigeo Murayama, Ichiro Imafuku

JOURNAL OF THE NEUROLOGICAL SCIENCES　Vol. 343　No. 1-2　p. 149-152　2014/08　Research paper (scientific journal)

Regional analysis of striatal and cortical amyloid deposition in patients with Alzheimer's disease.

Ishibashi K, Ishiwata K, Toyohara J, Murayama S, Ishii K

The European journal of neuroscience　Vol. 40　No. 4　p. 2701-2706　2014/08　Research paper (scientific journal)

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor

Hiroshi Hasegawa, Lei Liu, Ikuo Tooyama, Shigeo Murayama, Masaki Nishimura

Nature Communications　Vol. 5　2014/06/04　Research paper (scientific journal)

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease.

Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kitamura N, Akazawa K, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T, Kuwano R, Japanese Alzheimer's, Disease Neuroimaging Initiative

Translational psychiatry　Vol. 4　2014/06

Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene

Qina Temu, Sanjo Nobuo, Hizume Masaki, Higuma Maya, Tomita Makoto, Atarashi Ryuichiro, Satoh Katsuya, Nozaki Ichiro, Hamaguchi Tsuyoshi, Nakamura Yosikazu, Kobayashi Atsushi, Kitamoto Tetsuyuki, Murayama Shigeo, Murai Hiroyuki, Yamada Masahito, Mizusawa Hidehiro

BMJ Open　Vol. 4　No. 5　2014/05/16

Influence of APOE genotype and the presence of Alzheimer's pathology on synaptic membrane lipids of human brains

Naoto Oikawa, Hiroyuki Hatsuta, Shigeo Murayama, Akemi Suzuki, Katsuhiko Yanagisawa

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 92　No. 5　p. 641-650　2014/05　Research paper (scientific journal)

Human prion diseases in Japan: a prospective surveillance from 1999

Sanjo Nobuo, Higuma Maya, Hizume Masaki, Furukawa Fumiko, Nakamura Yosikazu, Kitamoto Tetsuyuki, Yamada Masahito, Sakai Kenji, Nozaki Ichiro, Noguchi-Shinohara Moeko, Hamaguchi Tsuyoshi, Moriwaka Fumio, Aoki Masashi, Tanaka Fumiaki, Nishizawa Masatoyo, Takeda Masatoshi, Inuzuka Takashi, Abe Koji, Murai Hiroyuki, Murayama Shigeo, Takao Masaki, Satoh Katsuya, Harada Masafumi, Saito Nobuhito, Takumi Ichirou, Mizusawa Hidehiro

PRION　Vol. 8　2014/04

多巣性進行性神経症状を呈し、リウマチ性髄膜炎類似生検所見を認めた62歳女性例

森本 悟, 砂川 昌子, 櫻井 圭太, 小宮 正, 筑井 恵美子, 新井 冨夫, 高尾 昌樹, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 54　No. 3　p. 255-255　2014/03

認知症研究のトピックス BACE1の細胞内安定性をコントロールするバイセクト糖鎖

北爪 しのぶ, 木塚 康彦, 藤縄 玲子, 斉藤 貴志, 岩田 修永, 西道 隆臣, 中の 三弥子, 山口 芳樹, 橋本 康弘, 初田 裕幸, 村山 繁雄, 萬谷 博, 遠藤 玉夫, 谷口 直之

日本薬学会年会要旨集　Vol. 134年会　No. 1　p. 135-135　2014/03

The homologous carboxyl-terminal domains of microtubule-associated protein 2 and Tau induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles

Ce Xie, Tomohiro Miyasaka, Satomi Yoshimura, Hiroyuki Hatsuta, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani, Shigeo Murayama, Yasuo Ihara

PLoS ONE　Vol. 9　No. 2　2014/02/25　Research paper (scientific journal)

Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in Japan

Megumi Yamada, Masaki Tanaka, Mari Takagi, Seiju Kobayashi, Yoshiharu Taguchi, Shutaro Takashima, Kortaro Tanaka, Tetsuo Touge, Hiroyuki Hatsuta, Shigeo Murayama, Yuichi Hayashi, Masayuki Kaneko, Hiroyuki Ishiura, Jun Mitsui, Naoki Atsuta, Gen Sobue, Nobuyuki Shimozawa, Takashi Inuzuka, Shoji Tsuji, Isao Hozumi

Neurology　Vol. 82　No. 8　p. 705-712　2014/02/25　Research paper (scientific journal)

Conference Room 原発不明がんによる腹膜播種を示した80歳女性

佐々木 美奈, 広吉 祐子, 櫻井 圭太, 山川 通隆, 永田 卓士, 横山 幸太, 原田 和昌, 荒井 和子, 小山 照幸, 村山 繁雄, 新井 冨生

内科　Vol. 113　No. 2　p. 343-352　2014/02

Altered CpG methylation in sporadic alzheimer's disease is associated with APP and MAPT dysregulation

Atsushi Iwata, Kenichi Nagata, Hiroyuki Hatsuta, Hiroshi Takuma, Miki Bundo, Kazuya Iwamoto, Akira Tamaoka, Shigeo Murayama, Takaomi Saido, Shoji Tsuji

Human Molecular Genetics　Vol. 23　No. 3　p. 648-656　2014/02　Research paper (scientific journal)

3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease

Masato Hasegawa, Sayuri Watanabe, Hiromi Kondo, Haruhiko Akiyama, David M. A. Mann, Yuko Saito, Shigeo Murayama

ACTA NEUROPATHOLOGICA　Vol. 127　No. 2　p. 303-305　2014/02　Research paper (scientific journal)

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain

Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David M.A. Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama, Masato Hasegawa

Acta Neuropathologica Communications　Vol. 2　No. 1　2014/01/27　Research paper (scientific journal)

A 39 years old woman responding to modafinil with bilateral hypothalamic lesion associated with hyperthermia and hypersomnia: A case report

Naoko Saito, Masato Inoue, Kanehiro Hasuo, Takashi Kanbayashi, Shigeo Murayama, Sosuke Takeuchi

Clinical Neurology　Vol. 54　No. 7　p. 550-555　2014

Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders

Shigeto Nagao, Osamu Yokota, Chikako Ikeda, Naoya Takeda, Hideki Ishizu, Shigetoshi Kuroda, Koichiro Sudo, Seishi Terada, Shigeo Murayama, Yosuke Uchitomi

European Archives of Psychiatry and Clinical Neuroscience　Vol. 264　No. 4　p. 317-331　2014　Research paper (scientific journal)

Immunostaining of oxidized DJ-1 in human and mouse brains

Yoshiro Saito, Tomohiro Miyasaka, Hiroyuki Hatsuta, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita, Osamu Kusano-Arai, Hiroko Iwanari, Hiroyoshi Ariga, Takao Hamakubo, Yasukazu Yoshida, Etsuo Niki, Shigeo Murayama, Yasuo Ihara, Noriko Noguchi

Journal of Neuropathology and Experimental Neurology　Vol. 73　No. 7　p. 714-728　2014　Research paper (scientific journal)

Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease

Shinji Ito, Masaki Takao, Hiroyuki Hatsuta, Kazutomi Kanemaru, Tomio Arai, Yuko Saito, Masashi Fukayama, Shigeo Murayama

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY　Vol. 7　No. 4　p. 1714-1723　2014　Research paper (scientific journal)

Imaging spectrum of sporadic cerebral amyloid angiopathy: Multifaceted features of a single pathological condition

Keita Sakurai, Aya M. Tokumaru, Tomoya Nakatsuka, Shigeo Murayama, Shin Hasebe, Etsuko Imabayashi, Kazutomi Kanemaru, Masaki Takao, Hiroyuki Hatsuta, Kenji Ishii, Yuko Saito, Yuta Shibamoto, Noriyuki Matsukawa, Emiko Chikui, Hitoshi Terada

Insights into Imaging　Vol. 5　No. 3　p. 375-385　2014

Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases

Zen Kobayashi, Ito Kawakami, Tetsuaki Arai, Osamu Yokota, Kuniaki Tsuchiya, Hiromi Kondo, Yoko Shimomura, Chie Haga, Naoya Aoki, Masato Hasegawa, Masato Hosokawa, Kenichi Oshima, Kazuhiro Niizato, Hideki Ishizu, Seishi Terada, Mitsumoto Onaya, Manabu Ikeda, Kiyomitsu Oyanagi, Imaharu Nakano, Shigeo Murayama, Haruhiko Akiyama, Hidehiro Mizusawa

Journal of the Neurological Sciences　Vol. 335　No. 1-2　p. 89-95　2013/12/15　Research paper (scientific journal)

家族性視神経脊髄炎症例の臨床・病理学的検討

角谷 真人, 東原 真奈, 汐崎 祐, 角谷 彰子, 本郷 悠, 尾上 祐行, 池脇 克則, 初田 裕幸, 緒方 衝, 河合 俊明, 村山 繁雄, 海田 賢一

臨床神経学　Vol. 53　No. 12　p. 1626-1626　2013/12

ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.

Yuji Takahashi, Yoko Fukuda, Jun Yoshimura, Atsushi Toyoda, Kari Kurppa, Hiroyoko Moritoyo, Veronique V Belzil, Patrick A Dion, Koichiro Higasa, Koichiro Doi, Hiroyuki Ishiura, Jun Mitsui, Hidetoshi Date, Budrul Ahsan, Takashi Matsukawa, Yaeko Ichikawa, Takashi Moritoyo, Mayumi Ikoma, Tsukasa Hashimoto, Fumiharu Kimura, Shigeo Murayama, Osamu Onodera, Masatoyo Nishizawa, Mari Yoshida, Naoki Atsuta, Gen Sobue, Jennifer A Fifita, Kelly L Williams, Ian P Blair, Garth A Nicholson, Paloma Gonzalez-Perez, Robert H Brown Jr, Masahiro Nomoto, Klaus Elenius, Guy A Rouleau, Asao Fujiyama, Shinichi Morishita, Jun Goto, Shoji Tsuji

American journal of human genetics　Vol. 93　No. 5　p. 900-5　2013/11/07　Research paper (scientific journal)

YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression

Ikuko Mizuta, Kazuaki Takafuji, Yuko Ando, Wataru Satake, Motoi Kanagawa, Kazuhiro Kobayashi, Shushi Nagamori, Takayuki Shinohara, Chiyomi Ito, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Yoshikatsu Kanai, Shigeo Murayama, Masanori Nakagawa, Tatsushi Toda

Journal of Human Genetics　Vol. 58　No. 11　p. 711-719　2013/11

原因不明の片側胸水と比較的急速に増悪するびまん性胸膜肥厚を認め,呼吸不全により死亡した1例

高橋 英気, 望月 英明, 原田 和昌, 村山 繁雄, 新井 冨生, 飯塚 あい, 齊藤 陽子, 櫻井 圭太, 舟槻 晋吾, 横山 幸太, 山川 通隆, 東京都健康長寿医療センターCPC

内科　Vol. 112　No. 5　p. 1027-1035　2013/11

右半球優位病変を呈したFTDP-17の50歳女性例

眞鍋 葉子, 櫻井 圭太, 古田 光, 加藤 貴行, 村山 繁雄

臨床神経学　Vol. 53　No. 10　p. 877-877　2013/10

神経束内に無構造の沈着物を認めた原発性マクログロブリン血症に伴うニューロパチーの65歳男性例

角谷 彰子, 角谷 真人, 東原 真奈, 汐崎 祐, 尾上 祐行, 村山 繁雄, 清水 潤, 海田 賢一

臨床神経学　Vol. 53　No. 10　p. 886-886　2013/10

筋萎縮性側索硬化症の初期には、線維束自発電位が脱神経電位よりも多く観察される

東原 真奈, 園生 雅弘, 今福 一郎, 福武 敏夫, 畑中 裕己, 村山 繁雄, 井上 聖啓

臨床神経生理学　Vol. 41　No. 5　p. 418-418　2013/10

J-ADNI登録症例における初剖検例

古川 勝敏, 高尾 昌樹, 岡村 信行, 冨田 尚希, 村山 繁雄, 荒井 啓行

Dementia Japan　Vol. 27　No. 4　p. 490-490　2013/10

臍帯血移植後のCMV感染症治療中に意識障害を呈し、非典型的な画像及び病理所見を呈した脳脊髄炎の1症例

横山 幸太, 櫻井 圭太, 宮腰 重三郎, 村山 繁雄, 高尾 昌樹, 初田 裕幸, 長谷部 伸, 今林 悦子, 徳丸 阿耶

日本医学放射線学会秋季臨床大会抄録集　Vol. 49回　p. S534-S534　2013/09

耳介の炎症、鞍鼻、多関節炎、気管支壁肥厚を認め、ステロイド加療中に急性呼吸不全を来し死亡した1例

木村 百合香, 杉原 毅彦, 中島 麻理, 新井 冨生, 村山 繁雄, 桑島 巌, 初田 裕幸, 平野 史生, 稲松 孝思

Geriatric Medicine　Vol. 51　No. 8　p. 853-864　2013/08

Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake

Yasuhisa Sakurai, Kenji Ishii, Masahiro Sonoo, Yuko Saito, Shigeo Murayama, Atsushi Iwata, Kensuke Hamada, Izumi Sugimoto, Shoji Tsuji, Toru Mannen

Journal of Neurology　Vol. 260　No. 8　p. 1982-1991　2013/08　Research paper (scientific journal)

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Takashi Nonaka, Masami Masuda-Suzukake, Tetsuaki Arai, Yoko Hasegawa, Hiroyasu Akatsu, Tomokazu Obi, Mari Yoshida, Shigeo Murayama, David M.A. Mann, Haruhiko Akiyama, Masato Hasegawa

Cell Reports　Vol. 4　No. 1　p. 124-134　2013/07/11　Research paper (scientific journal)

【高血圧診療のすべて】目でみる高血圧 無症候性脳血管病変と脳萎縮

徳丸 阿耶, 櫻井 圭太, 村山 繁雄

日本医師会雑誌　Vol. 142　No. 特別1　p. S9-S9　2013/06

Differential Expression of Secreted Phosphoprotein 1 in the Motor Cortex among Primate Species and during Postnatal Development and Functional Recovery

Tatsuya Yamamoto, Takao Oishi, Noriyuki Higo, Shigeo Murayama, Akira Sato, Ichiro Takashima, Yoko Sugiyama, Yukio Nishimura, Yumi Murata, Kimika Yoshino-Saito, Tadashi Isa, Toshio Kojima

PLoS ONE　Vol. 8　No. 5　2013/05/31　Research paper (scientific journal)

Calsyntenin-3 C-Terminal Fragment Accumulates in Dystrophic Neurites Surrounding A beta Plaques in Tg2576 Mouse and Alzheimer Disease Brains Its Neurotoxic Role in Mediating Dystrophic Neurite Formation

Yoko Uchida, Fujiya Gomi, Shigeo Murayama, Hiroshi Takahashi

AMERICAN JOURNAL OF PATHOLOGY　Vol. 182　No. 5　p. 1718-1726　2013/05　Research paper (scientific journal)

臨床的にアルツハイマー型認知症が疑われた、海馬硬化症性認知症の1剖検例

西東 瑠璃, 池村 雅子, 田中 麻理子, 新谷 裕加子, 小島 太郎, 山口 泰弘, 村山 繁雄, 深山 正久

日本病理学会会誌　Vol. 102　No. 1　p. 390-390　2013/04

Suspected limited efficacy of γ-secretase modulators

Nobuto Kakuda, Kohei Akazawa, Hiroyuki Hatsuta, Shigeo Murayama, Yasuo Ihara

Neurobiology of Aging　Vol. 34　No. 4　p. 1101-1104　2013/04　Research paper (scientific journal)

Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases

Maya Higuma, Nobuo Sanjo, Katsuya Satoh, Yusei Shiga, Kenji Sakai, Ichiro Nozaki, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Tetsuyuki Kitamoto, Susumu Shirabe, Shigeo Murayama, Masahito Yamada, Jun Tateishi, Hidehiro Mizusawa

PLoS ONE　Vol. 8　No. 3　2013/03/28　Research paper (scientific journal)

Lewy body pathology in a patient with a homozygous Parkin deletion

Saori Miyakawa, Mieko Ogino, Sayaka Funabe, Akiko Uchino, Yasushi Shimo, Nobutaka Hattori, Masaaki Ichinoe, Tetuo Mikami, Makoto Saegusa, Kazutoshi Nishiyama, Hideo Mori, Yoshikuni Mizuno, Shigeo Murayama, Hideki Mochizuki

Movement Disorders　Vol. 28　No. 3　p. 388-391　2013/03　Research paper (scientific journal)

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue, Koji Yamanaka

EMBO Molecular Medicine　Vol. 5　No. 2　p. 221-234　2013/02　Research paper (scientific journal)

Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa

Sayaka Funabe, Masaki Takao, Yuko Saito, Hiroyuki Hatsuta, Mikiko Sugiyama, Shinji Ito, Kazutomi Kanemaru, Motoji Sawabe, Tomio Arai, Hideki Mochizuki, Nobutaka Hattori, Shigeo Murayama

Neuropathology　Vol. 33　No. 1　p. 47-58　2013/02

The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

Yoshinori Nishimoto, Shinichi Nakagawa, Tetsuro Hirose, Hirotaka Okano, Masaki Takao, Shinsuke Shibata, Satoshi Suyama, Ken-ichiro Kuwako, Takao Imai, Shigeo Murayama, Norihiro Suzuki, Hideyuki Okano

Molecular Brain　Vol. 6　No. 1　p. 31-31　2013　Research paper (scientific journal)

Increased number of astrocytes and macrophages/microglial cells in the corpus callosum in amyotrophic lateral sclerosis

Mikiko Sugiyama, Masaki Takao, Hiroyuki Hatsuta, Sayaka Funabe, Shinji Ito, Tomokazu Obi, Fumiaki Tanaka, Yoshiyuki Kuroiwa, Shigeo Murayama

Neuropathology　Vol. 33　No. 6　p. 591-599　2013

SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease.

Yanan Wen, Akinori Miyashita, Nobutaka Kitamura, Tamao Tsukie, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyasu Akatsu, Takayuki Yamamoto, Kenji Kosaka, Haruyasu Yamaguchi, Kohei Akazawa, Yasuo Ihara, Ryozo Kuwano

Journal of Alzheimer's disease : JAD　Vol. 35　No. 2　p. 387-94　2013　Research paper (scientific journal)

Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum

Makoto Takahashi, Kinya Ishikawa, Nozomu Sato, Masato Obayashi, Yusuke Niimi, Taro Ishiguro, Mitsunori Yamada, Yasuko Toyoshima, Hitoshi Takahashi, Takeo Kato, Masaki Takao, Shigeo Murayama, Osamu Mori, Yoshinobu Eishi, Hidehiro Mizusawa

Neuropathology　Vol. 32　No. 6　p. 595-603　2012/12

進行性核上性麻痺のRichardson症候群とparkinsonismの臨床病理学的検討

齊藤 祐子, 塩谷 彩子, 池田 謙輔, 野上 茜, 村田 美穂, 有馬 邦正, 村山 繁雄

臨床神経学　Vol. 52　No. 12　p. 1595-1595　2012/12

進行性核上性麻痺と皮質基底核変性症の臨床病理学的検討 亜分類との対応

池田 謙輔, 塩谷 彩子, 有馬 邦正, 村山 繁雄, 村田 美穂, 齊藤 祐子

臨床神経学　Vol. 52　No. 12　p. 1596-1596　2012/12

アミロイドβオリゴマーの形成と空間記憶障害における細胞質SODの役割

村上 一馬, 村田 央, 野田 義博, 金子 孝夫, 木下 憲明, 初田 裕幸, 村山 繁雄, 入江 一浩, 白澤 卓二, 清水 孝彦

Dementia Japan　Vol. 26　No. 4　p. 491-491　2012/10

Enhanced Antigen Retrieval of Amyloid β Immunohistochemistry: Re-evaluation of Amyloid β Pathology in Alzheimer Disease and Its Mouse Model

Hideaki Kai, Ryong-Woon Shin, Koichi Ogino, Hiroyuki Hatsuta, Shigeo Murayama, Tetsuyuki Kitamoto

Journal of Histochemistry and Cytochemistry　Vol. 60　No. 10　p. 761-769　2012/10　Research paper (scientific journal)

Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population

Hiroya Naruse, Yuji Takahashi, Tameko Kihira, Sohei Yoshida, Yasumasa Kokubo, Shigeki Kuzuhara, Hiroyuki Ishiura, Masaharu Amagasa, Shigeo Murayama, Shoji Tsuji, Jun Goto

Amyotrophic Lateral Sclerosis　Vol. 13　No. 6　p. 562-566　2012/10　Research paper (scientific journal)

膿瘍との鑑別が困難であった肺腫瘍・転移性脳腫瘍の1例

高橋 英気, 望月 英明, 井藤 英喜, 筑井 恵美子, 加藤 貴行, 鄭 仁煕, 徳丸 阿耶, 山川 通隆, 安藝 良一, 沢辺 元司, 高尾 昌樹, 新井 冨生, 村山 繁雄

内科　Vol. 110　No. 3　p. 469-479　2012/09

The TRK-Fused Gene Is Mutated in Hereditary Motor and Sensory Neuropathy with Proximal Dominant Involvement

Hiroyuki Ishiura, Wataru Sako, Mari Yoshida, Toshitaka Kawarai, Osamu Tanabe, Jun Goto, Yuji Takahashi, Hidetoshi Date, Jun Mitsui, Budrul Ahsan, Yaeko Ichikawa, Atsushi Iwata, Hiide Yoshino, Yuishin Izumi, Koji Fujita, Kouji Maeda, Satoshi Goto, Hidetaka Koizumi, Ryoma Morigaki, Masako Ikemura, Naoko Yamauchi, Shigeo Murayama, Garth A. Nicholson, Hidefumi Ito, Gen Sobue, Masanori Nakagawa, Ryuji Kaji, Shoji Tsujii

AMERICAN JOURNAL OF HUMAN GENETICS　Vol. 91　No. 2　p. 320-329　2012/08　Research paper (scientific journal)

α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.

Yasumasa Kokubo, Akira Taniguchi, Masato Hasegawa, Yuma Hayakawa, Satoru Morimoto, Misao Yoneda, Yoshihumi Hirokawa, Taizo Shiraishi, Yuko Saito, Shigeo Murayama, Shigeki Kuzuhara

Journal of neuropathology and experimental neurology　Vol. 71　No. 7　p. 625-30　2012/07　Research paper (scientific journal)

【バイオバンク構築における病理の役割】共同研究の起点として機能する我が国のバイオバンクの実例 東京都健康長寿医療センターの病理解剖由来組織バンクおよび日本における組織バンクの課題

沢辺 元司, 新井 冨生, 村山 繁雄, 清水 孝彦, 戸田 年総, 古田 耕, 増井 徹

病理と臨床　Vol. 30　No. 6　p. 624-628　2012/06

SOD1の減少はアルツハイマー病様病態を早期に発症させる

清水 孝彦, 村上 一馬, 村田 央, 野田 義博, 初田 裕幸, 村山 繁雄, 入江 一浩, 白澤 卓二

日本抗加齢医学会総会プログラム・抄録集　Vol. 12回　p. 170-170　2012/06

Braak's hypothesis and non-motor symptoms of Parkinson disease

Yuko Saito, Shigeo Murayama

Brain and Nerve　Vol. 64　No. 4　p. 444-452　2012/04/01

Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara

EMBO Molecular Medicine　Vol. 4　No. 4　p. 344-352　2012/04　Research paper (scientific journal)

広汎な帯状疱疹ウイルス脳炎を発症し、剖検に至った81歳男性例

遠藤 由理佳, 間野 達雄, 遠藤 浩信, 坊野 恵子, 中山 貴博, 村山 繁雄, 今福 一郎

日本内科学会関東地方会　Vol. 586回　p. 34-34　2012/03

SOD1に新規の変異を認めた家族性筋萎縮性側索硬化症の1剖検例

種井 善一, 池村 雅子, 黒飛 京子, 石川 俊平, 清水 潤, 村山 繁雄, 深山 正久

日本病理学会会誌　Vol. 101　No. 1　p. 299-299　2012/03

Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease: a reliability and agreement study

Koji Fujita, Masafumi Harada, Makoto Sasaki, Tatsuhiko Yuasa, Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Yusei Shiga, Katsuya Satoh, Ryuichiro Atarashi, Susumu Shirabe, Ken Nagata, Tetsuya Maeda, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji, Masahito Yamada, Hidehiro Mizusawa

BMJ OPEN　Vol. 2　No. 1　2012　Research paper (scientific journal)

Prognosis of amyotrophic lateral sclerosis in relation with pathological pattern of propagation

Shigeo Murayama, Yuko Saito

Clinical Neurology　Vol. 52　No. 11　p. 1066-1067　2012

Hyperpolarization-activated cyclic nucleotide gated channels: A potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease

Yuhki Saito, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Nobuyuki Kimura, Shigeo Murayama, Sunao Kaneko, Ryuichi Shigemoto, Keiji Imoto, Toshiharu Suzuki

Molecular Neurodegeneration　Vol. 7　No. 1　2012　Research paper (scientific journal)

Prion-like protein propagation in neurodegenerative diseases

Masato Hasegawa, Takashi Nonaka, Masami Suzukake, Hiroshi Tsuji, Akira Tamaoka, Mari Yoshida, Shigeo Murayama, Tetsuaki Arai, Haruhiko Akiyama

Clinical Neurology　Vol. 52　No. 11　p. 1325-1326　2012

Molecular analysis and biochemical classification of TDP-43 proteinopathy

Hasegawa Masato, Tsuji Hiroshi, Arai Tetsuaki, Kametani Fuyuki, Nonaka Takashi, Yamashita Makiko, Suzukake Masami, Hosokawa Masato, Yoshida Mari, Hatsuta Hiroyuki, Takao Masaki, Saito Yuko, Murayama Shigeo, Mann David, Akiyama Haruhiko, Akira Tamaok

Dementia and Geriatric Cognitive Disorders　Vol. 33　p. 103-104　2012

Molecular analysis and biochemical classification of TDP-43 proteinopathy

Hiroshi Tsuji, Tetsuaki Arai, Fuyuki Kametani, Takashi Nonaka, Makiko Yamashita, Masami Suzukake, Masato Hosokawa, Mari Yoshida, Hiroyuki Hatsuta, Masaki Takao, Yuko Saito, Shigeo Murayama, Haruhiko Akiyama, Masato Hasegawa, David M. A. Mann, Akira Tamaoka

Brain　Vol. 135　No. 11　p. 3380-3391　2012　Research paper (scientific journal)

A 71-year-old Man with Subacute Respiratory Failure and Amyotrophy in His Legs during Non-tuberculous Mycobacterial Infection and Pulmonary Aspergillosis

Vol. 63　No. 12　p. 1387-1395　2011/12

[Case report; a case of chronic progressive neuro-Behcet's disease with extensive brain atrophy].

Higashi M, Sanjo N, Murayama S, Ota K, Sugita S, Yokota T, Mizusawa H

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　Vol. 100　No. 12　p. 3618-3621　2011/12

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid beta Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

Kazuma Murakami, Nakaba Murata, Yoshihiro Noda, Shoichi Tahara, Takao Kaneko, Noriaki Kinoshita, Hiroyuki Hatsuta, Shigeo Murayama, Kevin J. Barnham, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 52　p. 44557-44568　2011/12　Research paper (scientific journal)

アルツハイマー病の分子治療戦略 新しい視点を求めて アミロイドβの毒性ターン構造を認識する抗体の開発

入江 一浩, 村上 一馬, 増田 裕一, 村田 央, 野田 義博, 初田 裕幸, 村山 繁雄, 清水 孝彦, 堀越 優子, 木下 憲明, 白澤 卓二

臨床神経学　Vol. 51　No. 11　p. 890-891　2011/11

Progressive nonfluent aphasia

Shigeo Murayama, Yuko Saito

Brain and Nerve　Vol. 63　No. 10　p. 1037-1046　2011/10/01

[Argyrophilic grains].

Saito Y, Adachi T, Murayama S

Nihon rinsho. Japanese journal of clinical medicine　Vol. 69 Suppl 8　p. 161-165　2011/10

Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease

Naomi Seki, Yuji Takahashi, Hiroyuki Tomiyama, Ekaterina Rogaeva, Shigeo Murayama, Yoshikuni Mizuno, Nobutaka Hattori, Connie Marras, Anthony E. Lang, Peter St George-Hyslop, Jun Goto, Shoji Tsuji

Journal of Human Genetics　Vol. 56　No. 9　p. 671-675　2011/09

MRI拡散強調画像(DWI)で皮質に散在性の高信号域が認められたCreutzfeldt-Jakob病(CJD)の58歳女性剖検例

小松 鉄平, 荒木 邦彦, 佐藤 進, 柴山 秀博, 福武 敏夫, 村山 繁雄

臨床神経学　Vol. 51　No. 8　p. 624-624　2011/08

Dissociation of beta-Amyloid From Lipoprotein in Cerebrospinal Fluid From Alzheimer&apos;s Disease Accelerates beta-Amyloid-42 Assembly

Ayumi Takamura, Takeshi Kawarabayashi, Tatsuki Yokoseki, Masao Shibata, Maho Morishima-Kawashima, Yuko Saito, Shigeo Murayama, Yasuo Ihara, Koji Abe, Mikio Shoji, Makoto Michikawa, Etsuro Matsubara

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 89　No. 6　p. 815-821　2011/06　Research paper (scientific journal)

Development of autopsy tissue bank applicable to proteome research

Sawabe Motoji, Arai Tomio, Murayama Shigeo, Shimizu Takahiko, Toda Toshifusa

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2011　p. 142-142　2011

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23

Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Nakaba Murata, Yoshihiro Noda, Hiroyuki Hatsuta, Shigeo Murayama, Takahiko Shimizu, Yuko Horikoshi, Noriaki Kinoshita, Takuji Shirasawa

Clinical Neurology　Vol. 51　No. 11　p. 890-891　2011

Neuropathology

Yuko Saito, Shigeo Murayama

Clinical Neurology　Vol. 51　No. 11　p. 1168-1171　2011

Seed, aggregation and propagation of abnormal proteins could explain neuro degeneration?

Shigeo Murayama

Clinical Neurology　Vol. 51　No. 11　p. 1097-1099　2011

Superficial siderosis associated with abundant τ and α-synuclein accumulation

Masaki Takao, Shigeo Murayama, Youji Yoshida, Ban Mihara

BMJ Case Reports　2011　Research paper (scientific journal)

Spinocerebellar ataxia type 2 is associated with Parkinsonism and Lewy body pathology

Masaki Takao, Masahiro Aoyama, Kinya Ishikawa, Yoshio Sakiyama, Harumi Yomono, Yuko Saito, Hiroshi Kurisaki, Ban Mihara, Shigeo Murayama

BMJ Case Reports　Vol. 2011　2011　Research paper (scientific journal)

[Autopsy case with autonomic failure, parkinsonism and progressive fronto-temporal atrophy].

Adachi T, Imafuku I, Kakuta Y, Murayama S, Kawamura M

Brain and nerve = Shinkei kenkyu no shinpo　Vol. 62　No. 12　p. 1343-1351　2010/12

臨床医のための神経病理 嗅球

宮川 統爾, 仙石 錬平, 齊藤 祐子, 村山 繁雄

Clinical Neuroscience　Vol. 28　No. 11　p. 1218-1219　2010/11

Monoclonal Antibody Against the Turn of the 42-Residue Amyloid beta-Protein at Positions 22 and 23

Kazuma Murakami, Yuko Horikoshi-Sakuraba, Nakaba Murata, Yoshihiro Noda, Yuichi Masuda, Noriaki Kinoshita, Hiroyuki Hatsuta, Shigeo Murayama, Takuji Shirasawa, Takahiko Shimizu, Kazuhiro Irie

ACS CHEMICAL NEUROSCIENCE　Vol. 1　No. 11　p. 747-756　2010/11　Research paper (scientific journal)

Prospective 10-year surveillance of human prion diseases in Japan

Ichiro Nozaki, Tsuyoshi Hamaguchi, Nobuo Sanjo, Moeko Noguchi-Shinohara, Kenji Sakai, Yosikazu Nakamura, Takeshi Sato, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Fumio Moriwaka, Yusei Shiga, Yoshiyuki Kuroiwa, Masatoyo Nishizawa, Shigeki Kuzuhara, Takashi Inuzuka, Masatoshi Takeda, Shigetoshi Kuroda, Koji Abe, Hiroyuki Murai, Shigeo Murayama, Jun Tateishi, Ichiro Takumi, Susumu Shirabe, Masafumi Harada, Atsuko Sadakane, Masahito Yamada

BRAIN　Vol. 133　No. 10　p. 3043-3057　2010/10　Research paper (scientific journal)

小脳と脳幹部に限局した進行性多巣性白質脳症の1剖検例

杉浦 明, 宍戸 丈郎, 山崎 公也, 小尾 智一, 溝口 功一, 村山 繁雄, 中道 一生

臨床神経学　Vol. 50　No. 10　p. 746-746　2010/10

臨床医のための神経病理 Lewy小体・Lewy神経突起のスペクトラム(3)

齊藤 祐子, 仙石 錬平, 村山 繁雄

Clinical Neuroscience　Vol. 28　No. 9　p. 962-963　2010/09

アミロイドβの毒性ターン構造特異的抗体

村上 一馬, 堀越 優子[櫻庭], 村田 央, 野田 義博, 増田 裕一, 木下 憲明, 初田 裕幸, 村山 繁雄, 白澤 卓二, 清水 孝彦, 入江 一浩

Dementia Japan　Vol. 24　No. 3　p. 400-400　2010/09

臨床医のための神経病理 Lewy小体・Lewy神経突起のスペクトラム(2)

齊藤 祐子, 池村 雅子, 村山 繁雄

Clinical Neuroscience　Vol. 28　No. 7　p. 722-723　2010/07

タクロリムスが有効であったステロイド抵抗性高齢発症皮膚筋炎の1例

望月 祐輔, 増田 義重, 木村 直樹, 石川 貴敏, 坪光 雄介, 稲松 孝思, 村山 繁雄, 杉原 毅彦

日本老年医学会雑誌　Vol. 47　No. 4　p. 346-346　2010/07

Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease

K. Ishibashi, K. Kanemaru, Y. Saito, S. Murayama, K. Oda, K. Ishiwata, H. Mizusawa, K. Ishii

Acta Neurologica Scandinavica　Vol. 122　No. 1　p. 46-51　2010/07　Research paper (scientific journal)

Cortical propagation of Creutzfeldt-Jakob disease with codon 180 mutation

Shunsuke Kobayashi, Yuko Saito, Toshiyuki Maki, Shigeo Murayama

Clinical Neurology and Neurosurgery　Vol. 112　No. 6　p. 520-523　2010/07　Research paper (scientific journal)

Neuropathological asymmetry in argyrophilic grain disease

Tadashi Adachi, Yuko Saito, Hiroyuki Hatsuta, Sayaka Funabe, Aya M. Tokumaru, Kenji Ishii, Tomio Arai, Motoji Sawabe, Kazutomi Kanemaru, Akinori Miyashita, Ryozo Kuwano, Kenji Nakashima, Shigeo Murayama

Journal of Neuropathology and Experimental Neurology　Vol. 69　No. 7　p. 737-744　2010/07　Research paper (scientific journal)

Neurological CPC 認知症を伴ったParkinson病85歳男性例

吉村 菜穂子, 本間 琢, 村山 繁雄, 織茂 智之, 横地 正之, 河村 満, 後藤 淳, 福田 隆浩, 藤ヶ崎 純子, 鈴木 正彦

BRAIN and NERVE: 神経研究の進歩　Vol. 62　No. 6　p. 635-642　2010/06

【レヴィ小体をめぐって】末梢神経のレヴィ小体

池村 雅子, 齊藤 祐子, 仙石 錬平, 深山 正久, 村山 繁雄

Brain Medical　Vol. 22　No. 2　p. 159-165　2010/06

心機能低下を合併し、ステロイド療法とシクロホスファミドパルス療法が有効であったChurg-Strauss症候群の1例

伊賀 祥子, 細矢 匡, 杉原 毅彦, 田中 旬, 増田 義重, 仁科 裕史, 村山 繁雄, 高橋 英気, 稲松 孝思

練馬医学会誌　Vol. 16　p. 61-62　2010/03

Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate

T. Terada, Y. Tsuboi, T. Obi, K. Doh-ura, S. Murayama, T. Kitamoto, T. Yamada, K. Mizoguchi

ACTA NEUROLOGICA SCANDINAVICA　Vol. 121　No. 2　p. 127-130　2010/02　Research paper (scientific journal)

Clinical and pathological characteristics of FUS/TLS-associated amyotrophic lateral sclerosis (ALS)

Shigeo Murayama

Clinical Neurology　Vol. 50　No. 11　p. 948-950　2010

α-Synuclein accumulation in skin nerve fibers revealed by skin biopsy in pure autonomic failure

T. Shishido, M. Ikemura, T. Obi, K. Yamazaki, T. Terada, A. Sugiura, Y. Saito, S. Murayama, K. Mizoguchi

Neurology　Vol. 74　No. 7　p. 608-610　2010　Research paper (scientific journal)

Validation of cardiac 123I-MIBG scintigraphy in patients with Parkinson's disease who were diagnosed with dopamine PET

Kenji Ishibashi, Yuko Saito, Shigeo Murayama, Kazutomi Kanemaru, Keiichi Oda, Kiichi Ishiwata, Hidehiro Mizusawa, Kenji Ishii

European Journal of Nuclear Medicine and Molecular Imaging　Vol. 37　No. 1　p. 3-11　2010/01　Research paper (scientific journal)

Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease

Keiko Akasaka-Manya, Hiroshi Manya, Yoko Sakurai, Boguslaw S. Wojczyk, Yasunori Kozutsumi, Yuko Saito, Naoyuki Taniguchi, Shigeo Murayama, Steven L. Spitalnik, Tamao Endo

GLYCOBIOLOGY　Vol. 20　No. 1　p. 99-106　2010/01　Research paper (scientific journal)

ブレインバンクの日米比較

仙石 錬平, 齊藤 祐子, Vonsattel Jean Paul, 村山 繁雄

臨床神経学　Vol. 49　No. 12　p. 999-999　2009/12

後縦靱帯骨化症病変にほぼ限局したサルコイドーシス77歳男性剖検例

初田 裕幸, 仁科 裕史, 砂川 昌子, 徳丸 阿耶, 新井 冨生, 村山 繁雄

脊椎脊髄ジャーナル　Vol. 22　No. 12　p. 1337-1344　2009/12

Spinocerebellar Ataxia Type 31 Is Associated with "Inserted" Penta-Nucleotide Repeats Containing (TGGAA)(n)

Nozomu Sato, Takeshi Amino, Kazuhiro Kobayashi, Shuichi Asakawa, Taro Ishiguro, Taiji Tsunemi, Makoto Takahashi, Tohru Matsuura, Kevin M. Flanigan, Sawa Iwasaki, Fumitoshi Ishino, Yuko Saito, Shigeo Murayama, Mari Yoshida, Yoshio Hashizume, Yuji Takahashi, Shoji Tsuji, Nobuyoshi Shimizu, Tatsushi Toda, Kinya Ishikawa, Hidehiro Mizusawa

AMERICAN JOURNAL OF HUMAN GENETICS　Vol. 85　No. 5　p. 544-557　2009/11　Research paper (scientific journal)

Imaging-pathologic correlation in corticobasal degeneration

Aya M. Tokumaru, Y. Saito, S. Murayama, K. Kazutomi, Y. Sakiyama, M. Toyoda, M. Yamakawa, H. Terada

American Journal of Neuroradiology　Vol. 30　No. 10　p. 1884-1892　2009/11　Research paper (scientific journal)

病初期より、FDG-PETにて著明な糖代謝の低下を認めたCreutzfeldt-Jakob病(CJD)の81歳女性例

江口 桂, 石井 賢二, 徳丸 阿耶, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 49　No. 9　p. 602-602　2009/09

Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer&apos;s disease

Mitsugu Fukuda, Fumihisa Kanou, Nobuko Shimada, Motoji Sawabe, Yuko Saito, Shigeo Murayama, Masakatsu Hashimoto, Naoki Maruyama, Akihito Ishigami

BIOMEDICAL RESEARCH-TOKYO　Vol. 30　No. 4　p. 227-233　2009/08　Research paper (scientific journal)

心機能低下を合併し、ステロイド療法とシクロフォスファミドパルス療法が有効であったChurg-Strauss症候群の1例

伊賀 祥子, 木村 直樹, 田中 旬, 増田 義重, 仁科 裕史, 高橋 英気, 村山 繁雄, 稲松 孝思, 杉原 毅彦

日本内科学会関東地方会　Vol. 564回　p. 29-29　2009/07

顕微鏡的多発性血管炎に対してステロイド療法中、原因不明の発熱が出現し、死亡した1例

杉原 毅彦, 木村 直樹, 村山 繁雄, 新井 冨生, 井藤 英喜, 稲松 孝思, 大田 雅嗣, 原田 和昌

Geriatric Medicine　Vol. 47　No. 3　p. 387-396　2009/03

プリオン病感染予防ガイドライン(2008年度版)要約

水澤 英洋, 黒岩 義之, 岸田 日帯, 鈴木 ゆめ, 北本 哲之, 毛利 資郎, 小林 寛伊, 大久保 憲, 信国 圭吾, 児玉 南海雄, 太組 一朗, 太田 謙司, 高木 幹正, 小森 康雄, 大橋 裕一, 坪田 一男, 落合 直之, 村山 繁雄, 田村 智英子, 中村 好一, 厚生労働科学研究費補助金, 難治性疾患克服研究事業プリオン病及び遅発性ウイルス感染症に関する調査研究班

医材と滅菌　No. 93　p. 52-84　2009/02　Research paper (scientific journal)

Significance of radio-pathological correlations: differentiating severe central nervous system infection from acute embolic infarction.

Tokumaru AM, Hasebe T, Terada H, Saito Y, Kanemaru K, Yamakawa M, Mizuno M, Murayama S

The neuroradiology journal　Vol. 21　No. 6　p. 824-829　2009/01

起立性低血圧症で初発し、病理学的にLewy小体病と診断した2症例

広吉 祐子, 齊藤 祐子, 平田 秀爾, 福武 敏夫, 池村 雅子, 村山 繁雄

臨床神経学　Vol. 48　No. 12　p. 1165-1165　2008/12

嗅球Lewy小体(LB)関連病理(LBAS)の老化における意義

仙石 錬平, 齊藤 祐子, 池村 雅子, 初田 裕幸, 崎山 快夫, 井上 聖啓, 村山 繁雄

臨床神経学　Vol. 48　No. 12　p. 1120-1120　2008/12

Significance of radio-pathological correlations: Differentiating severe central nervous system infection from acute embolic infarction

Aya Midori Tokumaru, T. Hasebe, H. Terada, Y. Saito, K. Kanemaru, M. Yamakawa, M. Mizuno, S. Murayama

Neuroradiology Journal　Vol. 21　No. 6　p. 824-829　2008/12　Research paper (scientific journal)

皮膚生検で診断しえた、レビー小体型純粋自律神経不全症の一例

宍戸 丈郎, 小尾 智一, 寺田 達弘, 杉浦 明, 山崎 公也, 溝口 功一, 池村 雅子, 齊藤 裕子, 村山 繁雄

日本自律神経学会総会プログラム・抄録集　Vol. 61回　p. 187-187　2008/11

プリオン病感染予防ガイドライン(2008年版)要約

水澤 英洋, 黒岩 義之, 岸田 日帯, 鈴木 ゆめ, 北本 哲之, 毛利 資郎, 小林 寛伊, 大久保 憲, 信国 圭吾, 児玉 南海雄, 太組 一朗, 太田 謙司, 高木 幹正, 小森 康雄, 大橋 裕一, 坪田 一男, 落合 直之, 村山 繁雄, 田村 智英子, 中村 好一, 厚生労働科学研究費補助金・難治性疾患克服研究事業プリオン病及び遅発性ウイルス感染症に関する調査研究班

日本透析医学会雑誌　Vol. 41　No. 11　p. np1-29　2008/11

Incidence and Extent of Lewy Body-Related alpha-Synucleinopathy in Aging Human Olfactory Bulb

Renpei Sengoku, Yuko Saito, Masako Ikemura, Hiroyuki Hatsuta, Yoshio Sakiyama, Kazutomi Kanemaru, Tomio Arai, Motoji Sawabe, Noriko Tanaka, Hideki Mochizuki, Kiyoharu Inoue, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 67　No. 11　p. 1072-1083　2008/11　Research paper (scientific journal)

[Neuropathology of frontotemporal dementia]

A

Rinsho shinkeigaku = Clinical neurology　Vol. 48　No. 11　p. 998-998　2008/11

Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosis

Yuji Takahashi, Naomi Seki, Hiroyuki Ishiura, Jun Mitsui, Takashi Matsukawa, Atsushi Kishino, Osamu Onodera, Masashi Aoki, Nobuyuki Shimozawa, Shigeo Murayama, Yasuto Itoyama, Yasuyuki Suzuki, Gen Sobue, Masatoyo Nishizawa, Jun Goto, Shoji Tsuji

Archives of Neurology　Vol. 65　No. 10　p. 1326-1332　2008/10　Research paper (scientific journal)

Lewy body pathology involves cutaneous nerves

Masako Ikemura, Yuko Saito, Renpei Sengoku, Yoshio Sakiyama, Hiroyuki Hatsuta, Kazutomi Kanemaru, Motoji Sawabe, Tomio Arai, Genta Ito, Takeshi Imatsubo, Masashi Fukayama, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 67　No. 10　p. 945-953　2008/10　Research paper (scientific journal)

死後脳を用いた晩期発症型アルツハイマー病の網羅的遺伝子発現解析

宮下 哲典, 斉藤 佑子, 柿田 明美, 荻島 創一, 田中 博, 村山 繁雄, 高橋 均, 井原 康夫, 桑野 良三

Dementia Japan　Vol. 22　No. 2　p. 176-176　2008/08

Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: A comparative clinicopathological study

Osamu Yokota, Kuniaki Tsuchiya, Seishi Terada, Hideki Ishizu, Hirotake Uchikado, Manabu Ikeda, Kiyomitsu Oyanagi, Imaharu Nakano, Shigeo Murayama, Shigetoshi Kuroda, Haruhiko Akiyama

Acta Neuropathologica　Vol. 115　No. 5　p. 561-575　2008/05　Research paper (scientific journal)

Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in A beta production

Yuriko Tachida, Kazuhiro Nakagawa, Takashi Saito, Takaomi C. Saido, Takashi Honda, Yuko Saito, Shigeo Murayama, Tamao Endo, Gaku Sakaguchi, Akira Kato, Shinobu Kitazume, Yasuhiro Hashimoto

JOURNAL OF NEUROCHEMISTRY　Vol. 104　No. 5　p. 1387-1393　2008/03　Research paper (scientific journal)

Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy

Masaya Hashimoto, Keiichi Kawasaki, Masahiko Suzuki, Kazuko Mitania, Shigeo Murayama, Masahiro Mishina, Keiichi Oda, Yuichi Kimura, Kiichi Ishiwata, Kenji Ishiia, Kiyoharu Inoue

NEUROREPORT　Vol. 19　No. 2　p. 145-150　2008/01　Research paper (scientific journal)

純粋レヴィー小体病の臨床神経病理

齊藤 祐子, 仙石 錬平, 池村 雅子, 金丸 和富, 村山 繁雄

臨床神経学　Vol. 47　No. 12　p. 1120-1120　2007/12

Lewy小体病(LBD)初期における嗅球病理の位置付け

仙石 錬平, 齊藤 祐子, 初田 裕幸, 崎山 快夫, 望月 秀樹, 井上 聖啓, 村山 繁雄

臨床神経学　Vol. 47　No. 12　p. 1150-1150　2007/12

高齢者の筋萎縮性側索硬化症では、ユビキチン化神経細胞質内封入体を高率に認める

初田 裕幸, 齊藤 祐子, 久保田 暁, 森 啓, 村山 繁雄

臨床神経学　Vol. 47　No. 12　p. 1092-1092　2007/12

Neuropathology of mild cognitive impairment

Yuko Saito, Shigeo Murayama

NEUROPATHOLOGY　Vol. 27　No. 6　p. 578-584　2007/12

【実地病理医に必要な神経病理 変性・炎症・小児】神経変性疾患 一般内臓器の検索が神経疾患の診断に果たす役割

村山 繁雄, 齊藤 祐子, 池村 雅子

病理と臨床　Vol. 25　No. 11　p. 1105-1110　2007/11

Molecular chaperone-mediated Tau protein metabolism counteracts the formation of granular Tau oligomers in human brain

N. Sahara, S. Maeda, Y. Yoshiike, T. Mizoroki, S. Yamashita, M. Murayama, J. -M. Park, Y. Saito, S. Murayama, A. Takashima

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 85　No. 14　p. 3098-3108　2007/11　Research paper (scientific journal)

[Neuropathological diagnosis of prion disease]

Murayama S, Saito Y, Hatsuta H, Sakiyama Y

Nippon rinsho. Japanese journal of clinical medicine　Vol. 65　p. 1401-1406　2007/08

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: Consensus of the Consortium for Frontotemporal Lobar Degeneration

Nigel J. Cairns, Eileen H. Bigio, Ian R.A. Mackenzie, Manuela Neumann, Virginia M.-Y. Lee, Kimmo J. Hatanpaa, Charles L. White III, Julie A. Schneider, Lea Tenenholz Grinberg, Glenda Halliday, Charles Duyckaerts, James S. Lowe, Ida E. Holm, Markus Tolnay, Koichi Okamoto, Hideaki Yokoo, Shigeo Murayama, John Woulfe, David G. Munoz, Dennis W. Dickson, Paul G. Ince, John Q. Trojanowski, David M.A. Mann

Acta Neuropathologica　Vol. 114　No. 1　p. 5-22　2007/07　Research paper (scientific journal)

Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease

Ikuko Mohri, Keiichi Kadoyama, Takahisa Kanekiyo, Yo Sato, Kuriko Kagitani-Shimono, Yuko Saito, Kinuko Suzuki, Takashi Kudo, Masatoshi Takeda, Yoshihiro Urade, Shigeo Murayama, Masako Taniike

Journal of Neuropathology and Experimental Neurology　Vol. 66　No. 6　p. 469-480　2007/06　Research paper (scientific journal)

Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease

Yuichi Fumimura, Masako Ikemura, Yuko Saito, Renpei Sengoku, Kazutomi Kanemaru, Motoji Sawabe, Tomio Arai, Genta Ito, Takeshi Iwatsubo, Masashi Fukayama, Hidehiro Mizusawa, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 66　No. 5　p. 354-362　2007/05　Research paper (scientific journal)

Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid

Takahisa Kanekiyo, Tadato Ban, Kosuke Aritake, Zhi-Li Huang, Wei-Min Qu, Issay Okazaki, Ikuko Mohri, Shigeo Murayama, Keiichi Ozono, Masako Taniike, Yuji Goto, Yoshihiro Urade

Proceedings of the National Academy of Sciences of the United States of America　Vol. 104　No. 15　p. 6412-6417　2007/04/10　Research paper (scientific journal)

A Japanese family with early-onset ataxia with motor and sensory neuropathy

Shunsuke Kobayashi, Hiroshi Takuma, Shigeo Murayama, Masaki Sakurai, Ichiro Kanazawa

Journal of the Neurological Sciences　Vol. 254　No. 1-2　p. 44-48　2007/03/15　Research paper (scientific journal)

Granular tau oligomers as intermediates of tau filaments

Sumihiro Maeda, Naruhiko Sahara, Yuko Saito, Miyuki Murayama, Yuji Yoshiike, Hyonchol Kim, Tomohiro Miyasaka, Shigeo Murayama, Atsushi Ikai, Akihiko Takashima

BIOCHEMISTRY　Vol. 46　No. 12　p. 3856-3861　2007/03　Research paper (scientific journal)

Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia

Kazuyuki Ishida, Hiroshi Mitoma, Yoshiaki Wada, Teruaki Oka, Junji Shibahara, Yuko Saito, Shigeo Murayama, Hidehiro Mizusawa

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　Vol. 78　No. 2　p. 190-192　2007/02　Research paper (scientific journal)

Neuropathology of progressive multifocal leukoencephalopathy

Shigeo Murayama, Yuko Saito

Brain and Nerve　Vol. 59　No. 2　p. 119-124　2007/02　Research paper (scientific journal)

[Neuropathology of progressive multifocal leukoencephalopathy]

Murayama S, Saito Y

Brain and nerve = Shinkei kenkyu no shinpo　Vol. 59　p. 119-124　2007/02

レヴィー小体病の末梢自律神経系の病理評価に副腎は有用である

文村 優一, 齋藤 祐子, 池村 雅子, 金丸 和冨, 沢辺 元司, 水澤 英洋, 村山 繁雄

臨床神経学　Vol. 46　No. 12　p. 1075-1075　2006/12

臨床上Parkinsonismを認めた、高齢者連続剖検例の後方視的検索

仙石 錬平, 齊藤 祐子, 池村 雅子, 沢辺 元司, 井上 聖啓, 村山 繁雄

臨床神経学　Vol. 46　No. 12　p. 1075-1075　2006/12

レヴィー小体型痴呆改定ガイドラインの検討

村山 繁雄, 齊藤 祐子, 仙石 錬平, 池村 雅子, 崎山 快夫, 初田 裕幸, 金丸 和富

臨床神経学　Vol. 46　No. 12　p. 1076-1076　2006/12

A 52-year-old man with hypohidrosis

Jun Shimizu, Meiko Hashimoto, Shigeo Murayama, Shoji Tsuji

Neuropathology　Vol. 26　No. 6　p. 592-594　2006/12

[Brain bank]

Murayama S, Saito Y

No to shinkei = Brain and nerve　Vol. 58　No. 12　p. 1075-1084　2006/12

神経変性疾患におけるゲノム神経病理

原田 三枝子, 崎山 快夫, 初田 裕幸, 仙石 錬平, 池村 雅子, 直井 信子, 愛敬 直雄, 村山 繁雄, 齊藤 祐子, 沢辺 元司, 新井 冨生

東京都福祉保健医療学会誌　Vol. 平成18年度　No. 口頭発表　p. 98-99　2006/10

Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease

A. M. Shiarli, R. Jennings, J. Shi, K. Bailey, Y. Davidson, J. Tian, E. H. Bigio, B. Ghetti, J. R. Murrell, M. B. Delisle, S. Mirra, B. Crain, P. Zolo, K. Arima, E. Iseki, S. Murayama, H. Kretzschmar, M. Neumann, C. Lippa, G. Halliday, J. MacKenzie, N. Khan, R. Ravid, D. Dickson, Z. Wszolek, T. Iwatsubo, S. M. Pickering-Brown, D. M.A. Mann

Neuropathology and Applied Neurobiology　Vol. 32　No. 4　p. 374-387　2006/08　Research paper (scientific journal)

Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: A pathological study of 1074 consecutive autopsy cases

M Sawabe, T Arai, Kasahara, I, A Hamamatsu, Y Esaki, K Nakahara, K Harada, K Chida, H Yamanouchi, T Ozawa, K Takubo, S Murayama, N Tanaka

ATHEROSCLEROSIS　Vol. 186　No. 2　p. 374-379　2006/06　Research paper (scientific journal)

Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients

Ken Umemura, Nobuyuki Yamashita, Xiaonian Yu, Kunimasa Arima, Takashi Asada, Takao Makifuchi, Shigeo Murayama, Yuko Saito, Kazutomi Kanamaru, Yuichi Goto, Shinichi Kohsaka, Ichiro Kanazawa, Hideo Kimura

Neuroscience Letters　Vol. 400　No. 1-2　p. 97-100　2006/05/29　Research paper (scientific journal)

Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease

Jun Mitsui, Yuko Saito, Toshimitsu Momose, Jun Shimizu, Noritoshi Arai, Junji Shibahara, Yoshikazu Ugawa, Ichiro Kanazawa, Shoji Tsuji, Shigeo Murayama

Journal of the Neurological Sciences　Vol. 243　No. 1-2　p. 101-104　2006/04/15　Research paper (scientific journal)

Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.

Ikuko Mizuta, Wataru Satake, Yuko Nakabayashi, Chiyomi Ito, Satoko Suzuki, Yoshio Momose, Yoshitaka Nagai, Akira Oka, Hidetoshi Inoko, Jiro Fukae, Yuko Saito, Motoji Sawabe, Shigeo Murayama, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Tatsushi Toda

Human molecular genetics　Vol. 15　No. 7　p. 1151-8　2006/04/01　Research paper (scientific journal)

An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies

Rohan de Silva, Tammaryn Lashley, Catherine Strand, Anna-Maria Shiarli, Jing Shi, Jinzhou Tian, Kathryn L. Bailey, Peter Davies, Eileen H. Bigio, Kunimasa Arima, Eizo Iseki, Shigeo Murayama, Hans Kretzschmar, Manuela Neumann, Carol Lippa, Glenda Halliday, James MacKenzie, Rivka Ravid, Dennis Dickson, Zbigniew Wszolek, Takeshi Iwatsubo, Stuart M. Pickering-Brown, Janice Holton, Andrew Lees, Tamas Revesz, David M.A. Mann

Acta Neuropathologica　Vol. 111　No. 4　p. 329-340　2006/04　Research paper (scientific journal)

Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease

S Maeda, N Sahara, Y Saito, S Murayama, A Ikai, A Takashima

NEUROSCIENCE RESEARCH　Vol. 54　No. 3　p. 197-201　2006/03

Lewy body-related alpha-synucleinopathy in aging

Y. Saito, N. N. Ruberu, M. Sawabe, T. Arai, H. Kazama, T. Hosoi, H. Yamanouchi, S. Murayama

PARKINSONISM & RELATED DISORDERS　Vol. 12　p. S106-S106　2006　Research paper (scientific journal)

Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains

Hirotsugu Harada, Akira Tamaoka, Kazuhiro Ishii, Shin'ichi Shoji, Satoshi Kametaka, Fuyuki Kametani, Yuko Saito, Shigeo Murayama

Neuroscience Research　Vol. 54　No. 1　p. 24-29　2006/01

Man-in-the-barrel syndrome caused by bilateral intratumoral hemorrhage

Shunsuke Kobayashi, Hirokazu Taniguchi, Shigeo Murayama, Masaki Sakurai, Ichiro Kanazawa

European Neurology　Vol. 54　No. 3　p. 164-166　2005/12　Research paper (scientific journal)

Unique tauopathy in Fukuyama-type congenital muscular dystrophy

Y Saito, Y Motoyoshi, T Kashima, N Izumiyama-Shimomura, T Toda, Nakano, I, M Hasegawa, S Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 64　No. 12　p. 1118-1126　2005/12　Research paper (scientific journal)

Tau-positive fine granules in the cerebral white matter: A novel finding among the tauopathies exclusive to parkinsonism-dementia complex of Guam

M Yamazaki, M Hasegawa, O Mori, S Murayama, K Tsuchiya, K Ikeda, KM Chen, Y Katayama, K Oyanagi

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 64　No. 10　p. 839-846　2005/10　Research paper (scientific journal)

両側声帯麻痺をきたしたCreutzfeldt-Jakob病症例の臨床病理学的検討

東原 真奈, 海野 聡子, 橋田 秀司, 武田 克彦, 武村 民子, 初田 裕幸, 齊藤 祐子, 村山 繁雄

NEUROINFECTION　Vol. 10　No. 2　p. 162-162　2005/09

Establishment of brain bank for aging research

Murayama Shigeo, Saito Yuko, Kanemaru Kazutomi, Tokumaru Aya, Ishii Kenji, Sawabe Motoji

Japanese Journal of Geriatrics　Vol. 42　No. 5　p. 483-489　2005/09

Possibility for neurogenesis in substantia nigra of parkinsonian brain

Kenji Yoshimi, Yong-Ri Ren, Tatsunori Seki, Masanori Yamada, Hideki Ooizumi, Masafumi Onodera, Yuko Saito, Shigeo Murayama, Hideyuki Okano, Yoshikuni Mizuno, Hideki Mochizuki

Annals of Neurology　Vol. 58　No. 1　p. 31-40　2005/07　Research paper (scientific journal)

Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease

A Ishigami, T Ohsawa, M Hiratsuka, H Taguchi, S Kobayashi, Y Saito, S Murayama, H Asaga, T Toda, N Kimura, N Maruyama

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 80　No. 1　p. 120-128　2005/04　Research paper (scientific journal)

Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases

K Tsuchiya, S Murayama, K Mitani, T Oda, K Arima, M Mimura, H Nagura, C Haga, H Akiyama, H Yamanouchi, H Mizusawa

ACTA NEUROPATHOLOGICA　Vol. 109　No. 4　p. 353-366　2005/04　Research paper (scientific journal)

Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases

M Sawabe, R Takahashi, S Matsushita, T Ozawa, T Arai, A Hamamatsu, K Nakahara, K Chida, H Yamanouchi, S Murayama, N Tanaka

ATHEROSCLEROSIS　Vol. 179　No. 2　p. 345-351　2005/04　Research paper (scientific journal)

嚥下困難を主徴とし,筋生検にてサルコイド結節を認めた1例

中田 均, 山之内 博, 東原 真奈, 齊藤 祐子, 村山 繁雄

臨床神経学　Vol. 45　No. 3　p. 260-260　2005/03

Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex

T. Katsuno, M. Morishima-Kawashima, Y. Saito, H. Yamanouchi, S. Ishiura, S. Murayama, Y. Ihara

Neurology　Vol. 64　No. 4　p. 687-692　2005/02/22　Research paper (scientific journal)

Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease

T. Hamaguchi, T. Kitamoto, T. Sato, H. Mizusawa, Y. Nakamura, M. Noguchi, Y. Furukawa, C. Ishida, I. Kuji, K. Mitani, S. Murayama, T. Kohriyama, S. Katayama, M. Yamashita, T. Yamamoto, F. Udaka, A. Kawakami, Y. Ihara, T. Nishinaka, S. Kuroda, N. Suzuki, Y. Shiga, H. Arai, M. Maruyama, M. Yamada

Neurology　Vol. 64　No. 4　p. 643-648　2005/02/22　Research paper (scientific journal)

Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads

Tomohiro Miyasaka, Atsushi Watanabe, Yuko Saito, Shigeo Murayama, David M. A. Mann, Mineo Yamazaki, Rivka Ravid, Maho Morishima-Kawashima, Kazuo Nagashima, Yasuo Ihara

Journal of Neuropathology and Experimental Neurology　Vol. 64　No. 8　p. 665-674　2005　Research paper (scientific journal)

プルキンエ細胞のsomatodendritic sproutingを中核病理とする家族性脊髄小脳変性症

久保田 暁, 齊藤 祐子, 後藤 順, 三谷 和子, 金丸 和富, 山之内 博, 村山 繁雄

臨床神経学　Vol. 44　No. 12　p. 1066-1066　2004/12

Parkinson disease with dementia - Responsible locus for dementia

Shigeo Murayama, Yuko Saito, Kenji Ishii, Kazuko Mitani, Kazutomi Kanemaru, Hiroshi Yamanouchi, Hiroshi Kurisaki, Ichiro Imafuku

Clinical Neurology　Vol. 44　No. 11　p. 824-826　2004/11　Research paper (international conference proceedings)

Staging of argyrophilic grains: An age-associated tauopathy

Y Saito, NN Ruberu, M Sawabe, T Arai, N Tanaka, Y Kakuta, H Yamanouchi, S Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 63　No. 9　p. 911-918　2004/09　Research paper (scientific journal)

Neuropathological diagnostic criteria for Alzheimer's disease

S Murayama, Y Saito

NEUROPATHOLOGY　Vol. 24　No. 3　p. 254-260　2004/09

アルツハイマー病における老人斑周辺グリア細胞でのプロスタグランジンD2を介した炎症反応(Prostaglandin D2-mediated inflammation in glial cells associated with senile plaques in Alzheimer's disease)

角山 圭一, 毛利 育子, 佐藤 陽, 下野 九理子, 齋藤 祐子, 大薗 恵一, 村山 繁雄, 谷池 雅子, 裏出 良博

神経化学　Vol. 43　No. 2-3　p. 506-506　2004/08

Development of a geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP)

M Sawabe, T Arai, Kasahara, I, Y Esaki, K Nakahara, T Hosoi, H Orimo, K Takubo, S Murayama, N Tanaka

MECHANISMS OF AGEING AND DEVELOPMENT　Vol. 125　No. 8　p. 547-552　2004/08　Research paper (scientific journal)

Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia

Osamu Yokota, Seishi Terada, Takeshi Ishihara, Hanae Nakashima, Aki Kugo, Hiroshi Ujike, Kuniaki Tsuchiya, Kenji Ikeda, Yuko Saito, Shigeo Murayama, Hideki Ishizu, Shigetoshi Kuroda

Progress in Neuro-Psychopharmacology and Biological Psychiatry　Vol. 28　No. 4　p. 715-721　2004/07　Research paper (scientific journal)

既知の遺伝子異常を見いだせない,家族性小脳変性症の臨床病理学的検討

久保田 暁, 三谷 和子, 山之内 博, 後藤 順, 村山 繁雄

臨床神経学　Vol. 44　No. 7　p. 459-459　2004/07

Lewy body-related alpha-synucleinopathy in aging

Y Saito, NN Ruberu, M Sawabe, T Arai, H Kazama, T Hosoi, H Yamanouchi, S Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 63　No. 7　p. 742-749　2004/07　Research paper (scientific journal)

Granulomatous meningitis as a late complication of iodized oil myelography

NN Ruberu, Y Saito, N Honma, M Sawabe, H Yamanouchi, S Murayama

NEUROPATHOLOGY　Vol. 24　No. 2　p. 144-148　2004/06

アルツハイマー病と脱イミノ化蛋白質(Alzheimer's disease and deiminated proteins)

石神 昭人, 田口 ひろみ, 小林 沙織, 大澤 多加子, 齊藤 裕子, 村山 繁雄, 丸山 直記

基礎老化研究　Vol. 28　No. 2　p. 31-31　2004/05

Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia

Osamu Yokota, Seishi Terada, Hideki Ishizu, Takeshi Ishihara, Hanae Nakashima, Aki Kugo, Kuniaki Tsuchiya, Kenji Ikeda, Toshiyuki Hayabara, Yuko Saito, Shigeo Murayama, Kenji Uéda, Frédéric Checler, Shigetoshi Kuroda

Acta Neuropathologica　Vol. 107　No. 5　p. 399-405　2004/05　Research paper (scientific journal)

In situ detection of apolipoprotein E epsilon 4 in archival human brain

Y Saito, NN Ruberu, M Harada, T Arai, M Sawabe, N Nukina, S Murayama

NEUROREPORT　Vol. 15　No. 7　p. 1113-1115　2004/05　Research paper (scientific journal)

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease

Y Saito, K Suzuki, CM Hulette, S Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 63　No. 4　p. 323-328　2004/04　Research paper (scientific journal)

Pathology of the cerebral artery in Binswanger's disease in the aged: Observation by serial sections and morphometry of the cerebral arteries

R Okeda, S Murayama, M Sawabe, T Kuroiwa

NEUROPATHOLOGY　Vol. 24　No. 1　p. 21-29　2004/03

Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles

H Kazama, NN Ruberu, S Murayama, Y Saito, K Nakahara, K Kanemaru, H Nagura, T Arai, M Sawabe, H Yamanouchi, H Orimo, T Hosoi

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS　Vol. 18　No. 2　p. 145-150　2004　Research paper (scientific journal)

Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup

Y Takeda, K Akasaka, S Lee, S Kobayashi, H Kawano, S Murayama, N Takahashi, K Hashimoto, M Kano, M Asano, K Sudo, Y Iwakura, K Watanabe

JOURNAL OF NEUROBIOLOGY　Vol. 56　No. 3　p. 252-265　2003/09　Research paper (scientific journal)

Acute human T-lymphotropic virus type 1-associated myelopathy: A clinicopathologic study

Naoki Kasahata, Junichi Shiota, Yumi Miyazawa, Imaharu Nakano, Shigeo Murayama

Archives of Neurology　Vol. 60　No. 6　p. 873-876　2003/06/01　Research paper (scientific journal)

Accumulation of phosphorylated alpha-synuclein in aging human brain

Y Saito, A Kawashima, NN Ruberu, H Fujiwara, S Koyama, M Sawabe, T Arai, H Nagura, H Yamanouchi, M Hasegawa, T Iwatsubo, S Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　Vol. 62　No. 6　p. 644-654　2003/06　Research paper (scientific journal)

Magnetic resonance imaging findings of Machado-Joseph disease: Histopathologic correlation

Aya M. Tokumaru, Keiko Kamakura, Toshiyuki Maki, Shigeo Murayama, Ikuko Sakata, Tatsumi Kaji, Shinnya Kohyama, Shoichi Kusano, Seiji Hasegawa

Journal of Computer Assisted Tomography　Vol. 27　No. 2　p. 241-248　2003/03　Research paper (scientific journal)

Marked decrease of intracranial atherosclerosis in contrast with unchanged coronary artery stenosis in Japan

Shunichi Koyama, Yuko Saito, Hiroshi Yamanouchr, Hiroshi Nagura, Kouji Chida, Tomio Arai, Motoji Sawabe, Toshihiko Iwamoto, Masaru Takasaki, Shigeo Murayama

Japanese Journal of Geriatrics　Vol. 40　No. 3　p. 267-273　2003　Research paper (scientific journal)

右手振戦で発症し,15年近く良好なADLが保たれ,全経過20年で死亡したパーキンソン病の1剖検例

金丸 和富, 新井 冨生, 村山 繁雄, 名倉 博史

東京内科医会会誌　Vol. 18　No. 2　p. 113-121　2002/12

Niemann-Pick type C病とApoE ε4ホモ接合体の合併は,アルツハイマー病の病理を模倣する

齊藤 祐子, 山本 俊至, 難波 栄二, 大野 耕策, 鈴木 衣子, 村山 繁雄

臨床神経学　Vol. 42　No. 12　p. 1354-1354　2002/12

Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease

T Shimizu, H Fukuda, S Murayama, N Izumiyama, T Shirasawa

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 70　No. 3　p. 451-461　2002/11　Research paper (scientific journal)

Niemann-Pick type C disease: Accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity

Y Saito, K Suzuki, E Nanba, T Yamamoto, K Ohno, S Murayama

ANNALS OF NEUROLOGY　Vol. 52　No. 3　p. 351-355　2002/09　Research paper (scientific journal)

Association between a promoter polymorphism of the paraoxonase PON1 gene and pathologically verified idiopathic Parkinson's disease

KAZAMA Hirohito, HOSOI Takayuki, NAKAHARA Ken-ichi, MURAYAMA Shigeo, SAITO Yuko, KANEMARU Kazutomi, NAGURA Hiroshi, ARAI Tomio, SAWABE Motoji, TOBA Kenji, YAMANOUCHI Hiroshi, ORIMO Hajime

Geratrics and Gerontology International　Vol. 2　No. 2　p. 91-96　2002/06/01

Utilization behavior as a white matter disconnection syndrome

K Ishihara, H Nishino, T Maki, M Kawamura, S Murayama

CORTEX　Vol. 38　No. 3　p. 379-387　2002/06　Research paper (scientific journal)

ドーパミン-PETにてパーキンソン病様所見を呈した進行性核上性麻痺の一剖検例

中原 康雄, 三谷 和子, 名倉 博史, 山之内 博, 村山 繁雄

臨床神経学　Vol. 42　No. 5　p. 386-386　2002/05

Severe involvement of the ambient gyrus in a case of dementia with argyrophilic grain disease

Y Saito, M Yamazaki, Kanazawa, I, S Murayama

JOURNAL OF THE NEUROLOGICAL SCIENCES　Vol. 196　No. 1-2　p. 71-75　2002/04　Research paper (scientific journal)

Overlap syndrome of systemic lupus erythematosus and dermatomyositis presented a large demyelinating subcortical lesion mimicking brain tumor and high level of CSF antineuronal and serum anti-ribosomal P antibodies

Satoko Kano, Tomoki Nakamori, Ichiro Imafuku, Akira Sudo, Shigeo Inomori, Shigeo Murayama, Masanari Kunimoto

Clinical Neurology　Vol. 42　No. 3　p. 197-201　2002/03/01　Research paper (scientific journal)

Immunohistochemical diagnosis of Cryptococcus neoformans var. gattii infection in chronic meningoencephalitis: the first case in Japan

T Tsunemi, T Kamata, Y Fumimura, M Watanabe, M Yamawaki, Y Saito, T Kanda, K Ohashi, N Suegara, S Murayama, K Makimura, H Yamaguchi, H Mizusawa

INTERNAL MEDICINE　Vol. 40　No. 12　p. 1241-1244　2001/12　Research paper (scientific journal)

抗GD1b抗体の受け身移入による一次感覚ニューロンの軸索変性

楠 進, 等 誠司, 村山 繁雄, 金澤 一郎, 海田 賢一

臨床神経学　Vol. 40　No. 12　p. 1320-1320　2000/12

A severe case of subacute sarcoid myositis

H Takuma, S Murayama, M Watanabe, Y Saito, Y Ugawa, Kanazawa, I

JOURNAL OF THE NEUROLOGICAL SCIENCES　Vol. 175　No. 2　p. 140-144　2000/04　Research paper (scientific journal)

Central necrosis of the lumbo-sacral segment of the spinal cord associated with multiple cholesterin emboli, clinically presenting as acute paraplegia

M. Yoshimura, M. Uchigata, S. Shimizu, T. Sakamoto, S. Murayama

Clinical Neurology　Vol. 40　No. 10　p. 1038-1040　2000　Research paper (scientific journal)

Jugular foramen syndrome caused by varicella zoster virus infection in a patient with ipsilateral hypoplasia of the jugular foramen

Toshihiro Hayashi, Shigeo Murayama, Masaki Sakurai, Ichiro Kanazawa

Journal of the Neurological Sciences　Vol. 172　No. 1　p. 70-72　2000/01/01　Research paper (scientific journal)

A case of unilateral recurrent calf myalgia with muscle edema due to venous congestion

C. Nagai, Y. Oya, K. Nakamura, J. Shimizu, S. Murayama, I. Kanazawa

Clinical Neurology　Vol. 40　No. 7　p. 717-721　2000　Research paper (scientific journal)

Numerous conglomerate inclusions in slowly progressive familial amyotrophic lateral sclerosis with posterior column involvement

Sadao Katayama, Chigusa Watanabe, Kouichi Noda, Hitoshi Ohishi, Yasuhiro Yamamura, Takashi Nishisaka, Kouki Inai, Kohtaro Asayama, Shigeo Murayama, Shigenobu Nakamura

Journal of the Neurological Sciences　Vol. 171　No. 1　p. 72-77　1999/12/01　Research paper (scientific journal)

A clinico-pathological study of so-called 'acute multiple sclerosis' mimicking a brain tumor on the MRI findings

Naoki Kasahata, Shigeo Murayama, Jun-Ichi Shiota

Clinical Neurology　Vol. 39　No. 2-3　p. 327-332　1999/02　Research paper (scientific journal)

Accumulation of neurofilaments and SOD1-immunoreactive products in a patient with familial amyotrophic lateral sclerosis with I113T SOD1 mutation

Yasumasa Kokubo, Shigeki Kuzuhara, Yugo Narita, Koki Kikugawa, Ryoichi Nakano, Takashi Inuzuka, Shoji Tsuji, Masatoshi Watanabe, Tomonori Miyazaki, Shigeo Murayama, Yasuo Ihara

Archives of Neurology　Vol. 56　No. 12　p. 1506-1508　1999　Research paper (scientific journal)

Pelizaeus-Merzbacher disease: Three novel mutations and implication for locus heterogeneity

Hitoshi Osaka, Chiaki Kawanishi, Ken Inoue, Hideki Onishi, Takuya Kobayashi, Naoya Sugiyama, Kenji Kosaka, Atsuo Nezu, Katsunori Fujii, Katsuo Sugita, Kazuo Kodama, Keiko Murayama, Shigeo Murayama, Ichiro Kanazawa, Seiji Kimura

Annals of Neurology　Vol. 45　No. 1　p. 59-64　1999/01　Research paper (scientific journal)

Progressive aphemia in a patient with Pick's disease: A neuropsychological and anatomic study

Yasuhisa Sakurai, Shigeo Murayama, Youko Fukusako, Mitsuaki Bando, Makoto Iwata, Kiyoharu Inoue

Journal of the Neurological Sciences　Vol. 159　No. 2　p. 156-161　1998/08/14　Research paper (scientific journal)

Distal sensory axonopathy after satin intoxication

K. Himuro, Shigeo Murayama, K. Nishiyama, T. Shinoe, H. Iwase, M. Nagao, T. Takatori, I. Kanazawa

Neurology　Vol. 51　No. 4　p. 1195-1197　1998　Research paper (scientific journal)

Superoxide dismutase-like immunoreactivity in spheroids in Hallervorden-Spatz disease

K. Nishiyama, S. Murayama, Y. Nishimura, K. Asayama, I. Kanazawa

Acta Neuropathologica　Vol. 93　No. 1　p. 19-23　1997　Research paper (scientific journal)

Gamma Knife Radiosurgery for Metastatic Brain Tumors: Neuropathological report of two autopsy cases and review of literatures

Masao Tago, Yukimasa Aoki, Keiichi Nakagawa, Atsuro Terahara, Yuzo Onogi, Kenji Hasezawa, Kenji Toyoda, Yasuhito Sasaki, Hiroki Kurita, Shigeo Murayama

Nippon Acta Radiologica　Vol. 57　No. 3　p. 119-126　1997　Research paper (scientific journal)

Unusual MRI and pathologic findings of progressive multifocal leukoencephalopathy complicating adultWiskott-Aldrich syndrome

T. Matsushima, K. Nakamura, T. Oka, N. Tachikawa, T. Sata, S. Murayama, N. Nukina, I. Kanazawa

Neurology　Vol. 48　No. 1　p. 279-282　1997　Research paper (scientific journal)

Corticobasal degeneration: MR with histopathologic comparison

Aya M. Tokumaru, Toshihiro O'uchi, Yutaka Kuru, Toshiyuki Maki, Shigeo Murayama, Yasushi Horichi

American Journal of Neuroradiology　Vol. 17　No. 10　p. 1849-1852　1996/11　Research paper (scientific journal)

Regional and cellular Presenilin 1 gene expression in human and rat tissues

Takashi Suzuki, Kazutoshi Nishiyama, Shigeo Murayama, Ayako Yamamoto, Shinji Sato, Ichiro Kanazawa, Yoshiyuki Sakaki

Biochemical and Biophysical Research Communications　Vol. 219　No. 3　p. 708-713　1996/02/27　Research paper (scientific journal)

Two cases of unexplained pupillary dysfunction after cardiac surgery in severely diabetic patients

T. Arai, Y. Yamada, S. Murayama, K. Suwa, K. Hanaoka

Japanese Journal of Anesthesiology　Vol. 43　No. 9　p. 1376-1380　1994　Research paper (scientific journal)

TRK immunoreactivity at neuronal dendrite and cell body

Hitoshi Okazawa, Kazutoshi Nishiyama, Masaki Kamei, Kazushige Washizaki, Shigeo Murayama, Shin Kwak, Ichiro Kanazawa

Biochemical and Biophysical Research Communications　Vol. 194　No. 2　p. 683-690　1993/07/30　Research paper (scientific journal)

Degeneration of posterior column nucleus, inferior olivary nucleus and cerebellar cortex: System degeneration or paraneoplastic disease?

T. Ishida, S. Murayama, K. Inoue, R. Machinami, M. Tomonaga, T. Mannen

Clinical Neuropathology　Vol. 9　No. 5　p. 262-267　1990　Research paper (scientific journal)

An Autopsy Case with Encephalitis Principally Confined to the Thalamus and Associated with Pulmonary and Gastric Cancers

Masao Nakahama, Toshio Fukusato, Rikuo Machinami, Shigeo Murayama, Imaharu Nakano, Masanori Tomonaga

Pathology International　Vol. 40　No. 5　p. 371-375　1990　Research paper (scientific journal)

A case of startle disease - electrophysiological analysis

K. Hashiomoto, Y. Ugawa, M. Kunimoto, S. Murayama, T. Mannen

Clinical Neurology　Vol. 28　No. 6　p. 630-635　1988　Research paper (scientific journal)

Familial asymptomatic hyperCKemia. A morphological and pharmacological study

S. Murayama, H. Beppu, T. Tubaki, A. Takagi

Clinical Neurology　Vol. 27　No. 1　p. 23-30　1987　Research paper (scientific journal)

An adult case of benign congenital muscular dystrophy (non-Fukuyama type)

S. Murayama, H. Beppu, T. Tsubaki

Clinical Neurology　Vol. 26　No. 4　p. 419-424　1986　Research paper (scientific journal)

A case of total agenesis of the corpus callosum. The diagnosis by NMR-CT and the localization of the speech center

M. Sakamoto, K. Takeda, M. Bandou, S. Murayama, M. Sakuta

Clinical Neurology　Vol. 25　No. 4　p. 454-457　1985　Research paper (scientific journal)