顔写真

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Okashita Naoki
岡下　修己
Okashita Naoki
岡下　修己
Graduate School of Frontier Biosciences　Department of Frontier Biosciences, Assistant Professor

Research History 2

  1. 2019/04 - Present
    Osaka University　Graduate School of Frontier Biosciences

  2. 2015/04 - 2019/03
    The University of Tokushima

Education 3

  1. Kwansei Gakuin University

    2012/04 - 2015/03

  2. Kwansei Gakuin University

    2010/04 - 2012/03

  3. Kwansei Gakuin University　School of Science and Technology　Department of Bioscience

    2006/04 - 2010/03

Professional Memberships 2

  1. THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

  2. 日本エピジェネティクス研究会

Research Areas 1

  1. Life sciences / Molecular biology /

Papers 13

  1. CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.

    Naoki Okashita, Ryo Maeda, Makoto Tachibana

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 20　2023/05/16　Research paper (scientific journal)

  2. Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY

    Naoki Okashita, Makoto Tachibana

    Sexual Development　p. 1-9　2021/09/28　Research paper (scientific journal)

    Publisher: S. Karger AG

  3. The mouse Sry locus harbors a cryptic exon that is essential for male sex determination.

    Shingo Miyawaki, Shunsuke Kuroki, Ryo Maeda, Naoki Okashita, Peter Koopman, Makoto Tachibana

    Science (New York, N.Y.)　Vol. 370　No. 6512　p. 121-124　2020/10/02　Research paper (scientific journal)

  4. The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency

    Maiko Yamamoto, Yoshiaki Suwa, Kohta Sugiyama, Naoki Okashita, Masanori Kawaguchi, Naoki Tani, Kazumi Matsubara, Akira Nakamura, Yoshiyuki Seki

    Journal of cell science　Vol. 133　No. 15　2020/08/14　Research paper (scientific journal)

    Publisher: NLM (Medline)

  5. PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during transition from primed to naïve pluripotency

    Maiko Yamamoto, Yoshiaki Suwa, Kohta Sugiyama, Naoki Okashita, Masanori Kawaguchi, Naoki Tani, Kazumi Matsubara, Akira Nakamura, Yoshiyuki Seki

    Journal of Cell Science　p. jcs.240176-jcs.240176　2020/07/13　Research paper (scientific journal)

    Publisher: The Company of Biologists

  6. TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.

    Naoki Okashita, Shunsuke Kuroki, Ryo Maeda, Makoto Tachibana

    Scientific reports　Vol. 9　No. 1　p. 13462-13462　2019/09/17　Research paper (scientific journal)

  7. Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.

    Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana

    Stem cell reports　Vol. 10　No. 4　p. 1340-1354　2018/04/10　Research paper (scientific journal)

  8. Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

    Shunsuke Kuroki, Naoki Okashita, Shoko Baba, Ryo Maeda, Shingo Miyawaki, Masashi Yano, Miyoko Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Akihiro Itoh, Minoru Yoshida, Makoto Tachibana

    PLOS GENETICS　Vol. 13　No. 9　p. e1007034-e1007034　2017/09　Research paper (scientific journal)

  9. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency

    Naoki Okashita, Yoshiaki Suwa, Osamu Nishimura, Nao Sakashita, Mitsutaka Kadota, Go Nagamatsu, Masanori Kawaguchi, Hiroki Kashida, Ayaka Nakajima, Makoto Tachibana, Yoshiyuki Seki

    STEM CELL REPORTS　Vol. 7　No. 6　p. 1072-1086　2016/12　Research paper (scientific journal)

  10. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation

    Naoki Okashita, Nao Sakashita, Ken Ito, Ayaka Mitsuya, Yoshiaki Suwa, Yoshiyuki Seki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 466　No. 1　p. 138-145　2015/10　Research paper (scientific journal)

  11. PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells

    Naoki Okashita, Yuichi Kumaki, Kuniaki Ebi, Miyuki Nishi, Yoshinori Okamoto, Megumi Nakayama, Shota Hashimoto, Tomohumi Nakamura, Kaoru Sugasawa, Nakao Kojima, Tatsuyuki Takada, Masaki Okano, Yoshiyuki Seki

    DEVELOPMENT　Vol. 141　No. 2　p. 269-280　2014/01　Research paper (scientific journal)

  12. A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells

    Rika Ohno, Megumi Nakayama, Chie Naruse, Naoki Okashita, Osamu Takano, Makoto Tachibana, Masahide Asano, Mitinori Saitou, Yoshiyuki Seki

    DEVELOPMENT　Vol. 140　No. 14　p. 2892-2903　2013/07　Research paper (scientific journal)

  13. Epigenetic reprogramming in primordial germ cells in mice

    Yoshiyuki Seki, Naoki Okashita

    Journal of Mammalian Ova Research　Vol. 30　No. 3　p. 95-100　2013　Research paper (scientific journal)

Misc. 2

  1. 脱メチル化

    岡下 修己, 立花 誠

    生体の科学　Vol. 69　No. 5　p. 406-407　2018/10

  2. 始原生殖細胞によるエピゲノムリプログラミング

    関 由行, 岡下 修己

    Journal of mammalian ova research = 日本哺乳動物卵子学会誌　Vol. 30　No. 3　p. 95-100　2013/10

    Publisher: 日本哺乳動物卵子学会

Presentations 1

  1. Elucidation of novel epigenetic regulatory machanism of the sex-determining gene “Sry”

    Naoki Okashita

    KEY Forum 2018　2018/01/11