keyword PACAP
Osaka University
2000/04 - 2003/03
Osaka University
1998/04 - 2000/03
日本精神神経学会 評議員 Academic society
2018 - Present
日本薬理学会 学術評議員 Academic society
2018/01 - Present
The International College of Neuropsychopharmacology
THE JAPANESE BIOCHEMICAL SOCIETY
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
THE JAPANESE PHARMACOLOGICAL SOCIETY
THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
Life sciences / Laboratory animal science /
Life sciences / Pharmacology /
優秀演題発表賞
早田 敦子 BPCNPNPPP4学会合同年会 2022/11
CINP2018 Award for the Best Poster
HAYATA ATSUKO CINP 2018/06
JSNP Excellent Presentation Award for CINP2014
HAYATA ATSUKO 2014/06
平成26年度 大阪大学総長奨励賞
早田 敦子 大阪大学 2014/05
JSNP Excellent Presentation Award for CINP2012
早田 敦子 日本神経精神薬理学会 2012/06
Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models.
Yusuke Shintani, Atsuko Hayata-Takano, Ichiro Takasaki, Takashi Kurihara, Atsuro Miyata, Yui Yamano, Manato Ikuta, Rei Takeshita, Kenichiro Murata, Taisei Oguri, Chiaki Asaka, Kazuto Nunomura, Bangzhong Lin, Shinsaku Nakagawa, Takuya Okada, Naoki Toyooka, Toru Takumi, Yukio Ago, Kazuhiro Takuma, Hitoshi Hashimoto
Molecular psychiatry 2025/09/04 Research paper (scientific journal)
Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model.
Hiroki Ueno, Yusuke Iyanaga, Katsuyuki Kunida, Yuta Hara, Hiroki Miura, Yuka Nakai, Masato Tanuma, Misuzu Hayashida, Rei Yokoyama, Jin Ohkubo, Kaoru Seiriki, Atsuko Hayata-Takano, Tomoka Ao, Shun Yamaguchi, Shiho Kitaoka, Tomoyuki Furuyashiki, Yukio Ago, Takanobu Nakazawa, Kazuhiro Takuma, Junichiro Yoshimoto, Hitoshi Hashimoto, Atsushi Kasai
Scientific reports Vol. 15 No. 1 p. 22895-22895 2025/07/02 Research paper (scientific journal)
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth G N Grant, Michiru Ida-Eto, Masaaki Narita, Ken-Ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa
eLife Vol. 12 2024/03/26 Research paper (scientific journal)
Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells.
Satoshi Asano, Ami Ono, Kaede Baba, Teru Uehara, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Souichi Yanamoto, Kotaro Tanimoto, Hitoshi Hashimoto, Yukio Ago
Journal of pharmacological sciences Vol. 154 No. 3 p. 139-147 2024/03 Research paper (scientific journal)
Pituitary Adenylate Cyclase-Activating Polypeptide deficient mice show length abnormalities of the axon initial segment
Misaki Iwahashi, Takeshi Yoshimura, Wakana Harigai, Kazuhiro Takuma, Hitoshi Hashimoto, Taiichi Katayama, Atsuko Hayata-Takano
Journal of Pharmacological Sciences 2023/08 Research paper (scientific journal)
Publisher: Elsevier BV
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
Satoshi Asano, Ami Ono, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kotaro Tanimoto, Hitoshi Hashimoto, Yukio Ago
Peptides Vol. 161 p. 170940-170940 2023/03 Research paper (scientific journal)
Publisher: Elsevier BV
Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice
Yusuke Shintani, Yui Yamano, Manato Kuta, Rei Takeshita, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, Hitoshi Hashimoto, Atsuko Hayata-Takano
Biochem Biophys Res Commun . Vol. 631 p. 146-151 2022/11 Research paper (scientific journal)
Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration.
Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A Waschek, Yukio Ago
Frontiers in Oncology Vol. 12 p. 852358-852358 2022/09 Research paper (scientific journal)
Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Molecular brain Vol. 15 No. 1 p. 26-26 2022/03/28 Research paper (scientific journal)
Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia
Yamamoto K, Kuriu T, Matsumura K, Nagayasu K, Tsurusaki Y, Miyake N, Yamamori H, Yasuda Y, Fujimoto M, Fujiwara M, Baba M, Kitagawa K, Takemoto T, Gotoda-Nishimura N, Takada T, Seiriki K, Hayata-Takano A, Kasai A, Ago Y, Kida S, Takuma K, Ono F, Matsumoto N, Hashimoto R, Hashimoto H, Nakazawa T
Translational Psychiatry Vol. 11 No. 1 p. 548-548 2021/10 Research paper (scientific journal)
PACAP–PAC1 signaling regulates serotonin 2A receptor internalization
Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Hitoshi Hashimoto
Frontiers in Endocrinology Vol. 12 p. 732456-732456 2021/10 Research paper (scientific journal)
Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder
Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Molecular Brain Vol. 14 No. 1 p. 56-56 2021/03 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice
Chihiro Kawaguchi, Norihito Shintani, Atsuko Hayata-Takano, Michiyoshi Hatanaka, Ai Kuromi, Reiko Nakamura, Yui Yamano, Yusuke Shintani, Katsuya Nagai, Soken Tsuchiya, Yukihiko Sugimoto, Atsushi Ichikawa, Yasushi Okuno, Yoshihiro Urade, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Shuh Narumiya, Takanobu Nakazawa, Atsushi Kasai, Yukio Ago, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto
Communications Biology Vol. 3 No. 1 2020/12 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki Baba, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Nature communications Vol. 11 No. 1 p. 859-859 2020/02/26 Research paper (scientific journal)
Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism.
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A Waschek, Hitoshi Hashimoto, Yukio Ago
Frontiers in neuroscience Vol. 14 p. 521-521 2020 Research paper (scientific journal)
Autism-associated protein kinase D2 regulates embryonic cortical neuron development.
Kensuke Matsumura, Masayuki Baba, Kazuki Nagayasu, Kana Yamamoto, Momoka Kondo, Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Toshihiko Kuriu, Tokuichi Iguchi, Makoto Sato, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Biochemical and biophysical research communications Vol. 519 No. 3 p. 626-632 2019/11/12 Research paper (scientific journal)
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Yuichiro Naka, Kensuke Matsumura, Momoka Kondo, Kana Yamamoto, Misuzu Hayashida, Atsushi Kasai, Yukio Ago, Kazuki Nagayasu, Atsuko Hayata-Takano, Akinori Takahashi, Shun Yamaguchi, Daisuke Mori, Norio Ozaki, Tadashi Yamamoto, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Vol. 44 No. 12 p. 2125-2135 2019/11 Research paper (scientific journal)
Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimoto
The Journal of neuroscience : the official journal of the Society for Neuroscience Vol. 39 No. 22 p. 4208-4220 2019/05/29 Research paper (scientific journal)
Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.
Kaoru Seiriki, Atsushi Kasai, Takanobu Nakazawa, Misaki Niu, Yuichiro Naka, Masato Tanuma, Hisato Igarashi, Kosei Yamaura, Atsuko Hayata-Takano, Yukio Ago, Hitoshi Hashimoto
Nature protocols Vol. 14 No. 5 p. 1509-1529 2019/05 Research paper (scientific journal)
精神疾患におけるVPAC2受容体の病態生理学的役割
吾郷由希夫, 早田敦子, 橋本均
日本薬理学雑誌 Vol. 151 No. 6 p. 249-253 2018/06 Research paper (scientific journal)
Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism
Naoki Inoue, Sae Ogura, Atsushi Kasai, Takanobu Nakazawa, Kazuya Ikeda, Shintaro Higashi, Ayako Isotani, Kousuke Baba, Hideki Mochizuki, Harutoshi Fujimura, Yukio Ago, Atsuko Hayata-Takano, Kaoru Seiriki, Yusuke Shintani, Norihito Shintani, Hitoshi Hashimoto
EMBO Reports Vol. 19 No. 3 2018/03/01 Research paper (scientific journal)
Publisher: Wiley-VCH Verlag
Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response
Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N
Biochemical and biophysical research communications Vol. 495 No. 2 p. 1992-1997 2018/01 Research paper (scientific journal)
Publisher: Elsevier BV
Pathophysiological implication of the VPAC2 receptor in psychiatric disorders
Yukio Ago, Atsuko Hayata, Hitoshi Hashimoto
Folia Pharmacologica Japonica Vol. 151 No. 6 p. 249-253 2018 Research paper (scientific journal)
Publisher: Japanese Pharmacological Society
β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
Yusuke Shintani, Atsuko Hayata-Takano, Keita Moriguchi, Takanobu Nakazawa, Yukio Ago, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Hitoshi Hashimoto
PloS one Vol. 13 No. 5 2018 Research paper (scientific journal)
Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response
Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N
Biochem. Biophys. Re. Commun. Vol. 495 No. 2 p. 1992-1997 2017/12 Research paper (scientific journal)
Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice
Yukio Ago, Atsuko Hayata-Takano, Takuya Kawanai, Ryosuke Yamauchi, Shuto Takeuchi, Jesse D. Cushman, Abha K. Rajbhandari, Michael S. Fanselow, Hitoshi Hashimoto, James A. Waschek
NEUROBIOLOGY OF LEARNING AND MEMORY Vol. 145 p. 222-231 2017/11 Research paper (scientific journal)
分子から迫る神経薬理学 神経ペプチドPACAPおよびその受容体をターゲットとした臨床応用
早田敦子, 吾郷由希夫, 橋本均
Vol. 35 No. 10 p. 1150-1151 2017/10
分子から迫る神経薬理学 神経ペプチドPACAPおよびその受容体の発現分布と生理的作用
早田敦子, 吾郷由希夫, 橋本均
Clinical Neuroscience Vol. 35 No. 9 p. 1034-1036 2017/09
分子から迫る神経薬理学 神経ペプチドPACAPおよびその受容体の種類と構造
早田敦子, 吾郷由希夫, 橋本均
Clinical Neuroscience Vol. 35 No. 8 p. 912-913 2017/08
High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates
Kaoru Seiriki, Atsushi Kasai, Takeshi Hashimoto, Wiebke Schulze, Misaki Niu, Shun Yamaguchi, Takanobu Nakazawa, Ken-ichi Inoue, Shiori Uezono, Masahiko Takada, Yuichiro Naka, Hisato Igarashi, Masato Tanuma, James A. Waschek, Yukio Ago, Kenji F. Tanaka, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Hirooki Yabe, Takeharu Nagai, Katsumasa Fujita, Toshio Matsuda, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto
NEURON Vol. 94 No. 6 p. 1085-+ 2017/06 Research paper (scientific journal)
Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells frommonozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimoto
SCHIZOPHRENIA RESEARCH Vol. 181 p. 75-82 2017/03 Research paper (scientific journal)
Prostaglandin D-2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction
Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Takuya Kanoh, Yukio Ago, Toshio Matsuda, Ryota Hashimoto, Kazutaka Ohi, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Atsuko Hayata-Takano, Kazuki Nagayasu, Kazuhiro Takuma, Asao Ogawa, Akemichi Baba, Hitoshi Hashimoto
BEHAVIOURAL BRAIN RESEARCH Vol. 314 p. 77-86 2016/11 Research paper (scientific journal)
Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues
Atsushi Kasai, Sora Kakihara, Hiroki Miura, Ryo Okada, Atsuko Hayata-Takano, Keisuke Hazama, Misaki Niu, Norihito Shintani, Takanobu Nakazawa, Hitoshi Hashimoto
FRONTIERS IN MOLECULAR NEUROSCIENCE Vol. 9 2016/11 Research paper (scientific journal)
De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.
Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H
J Mol Psychiatry. Vol. 4 No. 1 2016/04 Research paper (scientific journal)
Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder
Ryota Hashimoto, Takanobu Nakazawa, Yoshinori Tsurusaki, Yuka Yasuda, Kazuki Nagayasu, Kensuke Matsumura, Hitoshi Kawashima, Hidenaga Yamamori, Michiko Fujimoto, Kazutaka Ohi, Satomi Umeda-Yano, Masaki Fukunaga, Haruo Fujino, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Masatoshi Takeda, Naomichi Matsumoto, Hitoshi Hashimoto
JOURNAL OF HUMAN GENETICS Vol. 61 No. 3 p. 199-206 2016/03 Research paper (scientific journal)
Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice
Kazuya Ikeda, Shuhei Tomimoto, Soken Tsuchiya, Ken-Ichi Hamagami, Norihito Shintani, Yukihiko Sugimoto, Atsushi Ichikawa, Atsushi Kasai, Takanobu Nakazawa, Kazuki Nagayasu, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto
Biochemistry and Biophysics Reports Vol. 2 p. 179-183 2015/07/01 Research paper (scientific journal)
Publisher: Elsevier
ATOMOXETINE REVERSES LOCOMOTOR HYPERACTIVITY, IMPAIRED NOVEL OBJECT RECOGNITION, AND PREPULSE INHIBITION IMPAIRMENT IN MICE LACKING PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
Y. Shibasaki, A. Hayata-Takano, K. Hazama, T. Nakazawa, N. Shintani, A. Kasai, K. Nagayasu, R. Hashimoto, M. Tanida, T. Katayama, S. Matsuzaki, K. Yamada, M. Taniike, Y. Onaka, Y. Ago, J. A. Waschek, K. Koeves, D. Regloedi, A. Tamas, T. Matsuda, A. Baba, H. Hashimoto
NEUROSCIENCE Vol. 297 p. 95-104 2015/06 Research paper (scientific journal)
p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice
Shintaro Higashi, Kazuhiko Katagi, Norihito Shintani, Kazuya Ikeda, Yukihiko Sugimoto, Soken Tsuchiya, Naoki Inoue, Shota Tanaka, Mai Koumoto, Atsushi Kasai, Takanobu Nakazawa, Atsuko Hayata-Takano, Ken-Ichi Hamagami, Shuhei Tomimoto, Takuya Yoshida, Tadayasu Ohkubo, Kazuki Nagayasu, Yukio Ago, Yusuke Onaka, Ryota Hashimoto, Atsushi Ichikawa, Akemichi Baba, Hitoshi Hashimoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 461 No. 4 p. 612-617 2015/06 Research paper (scientific journal)
CRTH2, a prostaglandin D-2 receptor, mediates depression-related behavior in mice
Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto
BEHAVIOURAL BRAIN RESEARCH Vol. 284 p. 131-137 2015/05 Research paper (scientific journal)
PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF
Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto
PLOS ONE Vol. 10 No. 3 2015/03 Research paper (scientific journal)
Simultaneous neuron- and astrocyte-specific fluorescent marking
Wiebke Schulze, Atsuko Hayata-Takano, Toshihiko Kamo, Takanobu Nakazawa, Kazuki Nagayasu, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Yukio Ago, Camille Farfan, Ryota Hashimoto, Akemichi Baba, Hitoshi Hashimoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 459 No. 1 p. 81-86 2015/03 Research paper (scientific journal)
Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro
Atsushi Yamasaki, Atsushi Kasai, Akihiro Toi, Maki Kurita, Saki Kimoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Akira Ito, Herbert Y. Meltzer, Yukio Ago, James A. Waschek, Yusuke Onaka, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF NEUROCHEMISTRY Vol. 132 No. 4 p. 418-428 2015/02 Research paper (scientific journal)
PACAPシグナルによる精神神経機能調節におけるセロトニン2A受容体シグナルの関与
Hayata-Takano A, Hazama K, Moriguchi K, Ago Y, Encho N, Nakazawa T, Nagayasu K, Kasai A, Onaka Y, Shintani N, Baba A, Hashimoto H
日本神経精神薬理学雑誌 Vol. 35 No. 2 p. 55-56 2015/02 Research paper (conference, symposium, etc.)
Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism
Kazuhiro Takuma, Yuta Hara, Shunsuke Kataoka, Takuya Kawanai, Yuko Maeda, Ryo Watanabe, Erika Takano, Atsuko Hayata-Takano, Hitoshi Hashimoto, Yukio Ago, Toshio Matsuda
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR Vol. 126 p. 43-49 2014/11 Research paper (scientific journal)
Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model.
Ryota Haba, Norihito Shintani, Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba
The Journal of neuroscience : the official journal of the Society for Neuroscience Vol. 34 No. 7 p. 2514-23 2014/02/12 Research paper (scientific journal)
Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice
Keisuke Hazama, Atsuko Hayata-Takano, Kazuki Uetsuki, Atsushi Kasai, Naoki Encho, Norihito Shintani, Kazuki Nagayasu, Ryota Hashimoto, Dora Reglodi, Tsuyoshi Miyakawa, Takanobu Nakazawa, Akemichi Baba, Hitoshi Hashimoto
PLOS ONE Vol. 9 No. 2 2014/02 Research paper (scientific journal)
Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner
M. Tanida, A. Hayata, N. Shintani, N. Yamamoto, Y. Kurata, T. Shibamoto, D. A. Morgan, K. Rahmouni, H. Hashimoto
Neuroscience Vol. 238 p. 297-304 2013/05/05 Research paper (scientific journal)
[Pituitary adenylate cyclase-activating polypeptide(PACAP) plays significant roles in mental function and neuronal development].
Hayata-Takano A, Seiriki K, Tajiri M, Ogata K, Shintani N, Baba A, Hashimoto H
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Vol. 33 No. 2 p. 73-75 2013/04
Characterization and Modeling of Intermittent Locomotor Dynamics in Clock Gene-Deficient Mice
Toru Nakamura, Toru Takumi, Atsuko Takano, Fumiyuki Hatanaka, Yoshiharu Yamamoto
PLOS ONE Vol. 8 No. 3 2013/03 Research paper (scientific journal)
PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: Persistent suppressive effects on islet density
Hiroaki Inoue, Norihito Shintani, Yusuke Sakurai, Shintaro Higashi, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto
Frontiers in Endocrinology Vol. 4 2013 Research paper (scientific journal)
The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide
Yukio Ago, Naoki Hiramatsu, Toshihiro Ishihama, Keisuke Hazama, Atsuko Hayata-Takano, Yasuhiro Shibasaki, Norihito Shintani, Hitoshi Hashimoto, Toshiyuki Kawasaki, Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda
BEHAVIOURAL PHARMACOLOGY Vol. 24 No. 1 p. 74-77 2013/01 Research paper (scientific journal)
PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: Persistent suppressive effects on islet density
Hiroaki Inoue, Norihito Shintani, Yusuke Sakurai, Shintaro Higashi, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto
Frontiers in Neuroscience Vol. 4 No. 7 p. 1-7 2013 Research paper (scientific journal)
Compensatory Recovery of Blood Glucose Levels in KKA(y) Mice Fed a High-Fat Diet: Insulin-Sparing Effects of PACAP Overexpression in beta Cells
Yusuke Sakurai, Hiroaki Inoue, Norihito Shintani, Akihiro Arimori, Ken-ichi Hamagami, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 48 No. 3 p. 647-653 2012/11 Research paper (scientific journal)
Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons Therapeutic Implications for Psychiatric Disorders
Minako Tajiri, Atsuko Hayata-Takano, Kaoru Seiriki, Katsuya Ogata, Keisuke Hazama, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 48 No. 3 p. 473-481 2012/11 Research paper (scientific journal)
A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells
Takeshi Shimada, Yoshihiro Takai, Kikuko Shinohara, Atsushi Yamasaki, Keiko Tominaga-Yoshino, Akihiko Ogura, Akihiro Toi, Kouji Asano, Norihito Shintani, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF NEUROCHEMISTRY Vol. 122 No. 1 p. 81-93 2012/07 Research paper (scientific journal)
Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala
Ryota Haba, Norihito Shintani, Yusuke Onaka, Hyper Wang, Risa Takenaga, Atsuko Hayata, Akemichi Baba, Hitoshi Hashimoto
BEHAVIOURAL BRAIN RESEARCH Vol. 228 No. 2 p. 423-431 2012/03 Research paper (scientific journal)
PACAP centrally mediates emotional stress-induced corticosterone responses in mice
Naohiro Tsukiyama, Yoko Saida, Michiya Kakuda, Norihito Shintani, Atsuko Hayata, Yoshiko Morita, Mamoru Tanida, Minako Tajiri, Keisuke Hazama, Katsuya Ogata, Hitoshi Hashimoto, Akemichi Baba
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS Vol. 14 No. 4 p. 368-375 2011/07 Research paper (scientific journal)
PACAP is Implicated in the Stress Axes
Hitoshi Hashimoto, Norihito Shintani, Mamoru Tanida, Atsuko Hayata, Ryota Hashimoto, Akemichi Baba
CURRENT PHARMACEUTICAL DESIGN Vol. 17 No. 10 p. 985-989 2011/04 Research paper (scientific journal)
Trophic Effects of PACAP on Pancreatic Islets: A Mini-Review
Yusuke Sakurai, Norihito Shintani, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 43 No. 1 p. 3-7 2011/01 Research paper (scientific journal)
Cerulein-Induced Acute Pancreatitis in PACAP Knockout Mice
Yusuke Sakurai, Norihito Shintani, Akihiro Arimori, Ken-ichi Hamagami, Naoko Higuchi, Hiroaki Inoue, Kazuya Ikeda, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 43 No. 1 p. 8-15 2011/01 Research paper (scientific journal)
15d-Prostaglandin J(2) Enhancement of Nerve Growth Factor-Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells
Michiyoshi Hatanaka, Norihiro Shibata, Norihito Shintani, Ryota Haba, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 113 No. 1 p. 89-93 2010/05 Research paper (scientific journal)
Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice
Kazuhiro Tanaka, Akiko Kunishige-Yamamoto, Hitoshi Hashimoto, Norihito Shintani, Atsuko Hayata, Akemichi Baba
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 391 No. 1 p. 773-777 2010/01 Research paper (scientific journal)
CKI epsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock
Yasushi Isojima, Masato Nakajima, Hideki Ukai, Hiroshi Fujishima, Rikuhiro G. Yamada, Koh-hei Masumoto, Reiko Kiuchi, Mayumi Ishida, Maki Ukai-Tadenuma, Yoichi Minami, Ryotaku Kito, Kazuki Nakao, Wataru Kishimoto, Seung-Hee Yoo, Kazuhiro Shimomura, Toshifumi Takao, Atsuko Takano, Toshio Kojima, Katsuya Nagai, Yoshiyuki Sakaki, Joseph S. Takahashi, Hiroki R. Ueda
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 106 No. 37 p. 15744-15749 2009/09 Research paper (scientific journal)
Of Mice and Men - Universality and Breakdown of Behavioral Organization
Toru Nakamura, Toru Takumi, Atsuko Takano, Naoko Aoyagi, Kazuhiro Yoshiuchi, Zbigniew R. Struzik, Yoshiharu Yamamoto
PLOS ONE Vol. 3 No. 4 2008/04 Research paper (scientific journal)
A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes
Yasukazu Nakahata, Mayumi Yoshida, Atsuko Takano, Haruhiko Soma, Takuro Yamamoto, Akio Yasuda, Toru Nakatsu, Toru Takumi
BMC MOLECULAR BIOLOGY Vol. 9 No. 1 2008/01 Research paper (scientific journal)
Serine 714 might be implicated in the regulation of the phosphorylation in other areas of mPer1 protein
A Takano, K Nagai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 346 No. 1 p. 95-101 2006/07 Research paper (scientific journal)
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders
A Takano, M Uchiyama, N Kajimura, K Mishima, Y Inoue, Y Kamei, T Kitajima, K Shibui, M Katoh, T Watanabe, Y Hashimotodani, T Nakajima, Y Ozeki, T Hori, N Yamada, R Toyoshima, N Ozaki, M Okawa, K Nagai, K Takahashi, Y Isojima, T Yamauchi, T Ebisawa
NEUROPSYCHOPHARMACOLOGY Vol. 29 No. 10 p. 1901-1909 2004/10 Research paper (scientific journal)
Sequence variations in human casein kinase1epsilon gene and circadian rhythm sleep disorders
A Takano, M Uchiyama, N Kajimura, K Mishima, Y Inoue, Y Kamei, T Kitajima, K Shibui, M Katoh, T Watanabe, Y Hashimotodani, T Nakajima, Y Ozeki, T Hori, N Yamada, R Toyoshima, N Ozaki, M Okawa, K Nagai, K Takahashi, Y Isojima, T Yamauchi, T Ebisawa
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS Vol. 130B No. 1 p. 152-153 2004/09 Research paper (scientific journal)
Identification of mPer1 phosphorylation sites responsible for the nuclear entry
A Takano, Y Isojima, K Nagai
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279 No. 31 p. 32578-32585 2004/07 Research paper (scientific journal)
Analysis of the expression, localization and activity of rat casein kinase I epsilon-3
A Takano, HS Hoe, Y Isojima, K Nagai
NEUROREPORT Vol. 15 No. 9 p. 1461-1464 2004/06 Research paper (scientific journal)
Cloning and characterization of rat casein kinase 1 epsilon
A Takano, K Shimizu, S Kani, RM Buijs, M Okada, K Nagai
FEBS LETTERS Vol. 477 No. 1-2 p. 106-112 2000/07 Research paper (scientific journal)
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus
K Shimizu, M Okada, A Takano, K Nagai
FEBS LETTERS Vol. 458 No. 3 p. 363-369 1999/09 Research paper (scientific journal)
Strategy for the development of small-molecule antidepressant targeting PAC1 receptor
Ichiro Takasaki, Atsuko Hayata-Takano, Yusuke Shintani, Takashi Kurihara, Hitoshi Hashimoto
Folia Pharmacologica Japonica Vol. 159 No. 4 p. 219-224 2024/07/01 Article, review, commentary, editorial, etc. (scientific journal)
Publisher: Japanese Pharmacological Society
ヒト染色体3q29領域欠失を導入した自閉スペクトラム症モデルマウスの社会性行動異常はオキシトシンにより回復する
竹本智哉, 馬場優志, 北川航平, 永安一樹, 永安一樹, 勢力薫, 勢力薫, 早田敦子, 早田敦子, 笠井淳司, 吾郷由希夫, 吾郷由希夫, 田熊一敞, 橋本均, 橋本均, 橋本均, 橋本均, 橋本均, 中澤敬信, 中澤敬信
日本薬理学雑誌 Vol. 157 No. Supplement 2022
胎児期におけるPGD2シグナル活性化による社会性行動や神経細胞形態への影響
菊池泰河, 早田敦子, 早田敦子, 橘雅弥, 橘雅弥, 毛利育子, 谷池雅子, 橋本均, 橋本均, 橋本均, 橋本均, 橋本均
日本薬理学雑誌 Vol. 157 No. Supplement 2022
胎児期PGD2受容体アゴニスト暴露は社会性行動や神経細胞形態に影響を及ぼす
早田敦子, 菊池泰河, 豊田博紀, 毛利育子, 橘雅弥, 橘雅弥, 加藤隆史, 加藤隆史, 谷池雅子, 橋本均, 橋本均, 橋本均, 橋本均, 橋本均
日本神経化学会大会抄録集(Web) Vol. 65th 2022
概日リズムのクロノタイプと気分障害に関わるストレスレジリエンス
早田敦子, 内匠透
生物学的精神医学会誌 Vol. 32 No. 4 p. 174-178 2021/12 Article, review, commentary, editorial, etc. (scientific journal)
発達障がいモデルマウスを用いた脳の発達や社会性に変化をもたらす分子メカニズム解明 ～全脳イメージング解析から，シナプス機能解析まで
早田敦子, 勢力薫, 中澤敬信, 橋本均
子どものこころと脳の発達 Vol. 12 No. 1 p. 17-25 2021/12
概日リズムに関わる時計遺伝子とストレス感受性・抵抗性
Clinical Neuroscience Vol. 39 No. 6 p. 780-783 2021/06 Article, review, commentary, editorial, etc. (scientific journal)
Publisher: (株)中外医学社PACAPシグナル系を介したストレスが誘発する精神疾患の発症機序の解明と治療薬の開発
早田 敦子, 吾郷 由希夫, 橋本 均
Medical Science Digest Vol. 46 No. 6 p. 54-57 2020/06 Article, review, commentary, editorial, etc. (scientific journal)
マウス新生仔へのプロスタグランジンD2受容体DP1作動薬による神経細胞の形態や行動への影響
早田 敦子, 奥田 健太, 毛利 育子, 橘 雅弥, 新谷 勇介, 菊池 泰河, 中澤 敬信, 谷池 雅子, 橋本 均
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 Vol. 28回・48回 p. 224-224 2018/11
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
認知機能制御におけるプロスタグランジンDP2受容体の役割(The role of prostanoid DP2 receptor in the regulation of cognitive function)
新谷 紀人, 尾中 勇祐, 叶 拓也, 中澤 敬信, 吾郷 由希夫, 松田 敏夫, 橋本 亮太, 大井 一高, 平井 博之, 永田 欽也, 中村 正孝, 笠井 淳司, 早田 敦子, 野, 永安 一樹, 馬場 明道, 橋本 均
日本神経精神薬理学会年会プログラム・抄録集 Vol. 46回 p. 232-232 2016/07
Publisher: (一社)日本神経精神薬理学会Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfunction in mice
Yukio Ago, Atsuko Hayata, Takuya Kawanai, Ryosuke Yamauchi, James A. Waschek, Hitoshi Hashimoto
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 19 p. 180-181 2016/06 Research paper, summary (international conference)
Studies on the molecular mechanism of clozapine action with iPSC technology
Fujiwara Mikiya, Kikuchi Masataka, Nagayasu Kazuki, Nakazawa Takanobu, Yamamori Hidenaga, Kasai Atsushi, Hayata-Takano Atsuko, Shintani Norihito, Fujimoto Michiko, Yasuda Yuka, Ishikawa Mitsuru, Akamatsu Wado, Okano Hideyuki, Nakaya Akihiro, Hashimoto Hitoshi, Hashimoto Ryota
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 130 No. 3 2016/03
A CROSSTALK BETWEEN PACAPAND SEROTONIN 2A SIGNALING
Keita Moriguchi, Atsuko Hayata, Naoki Encho, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 53 p. S148-S149 2014/08 Research paper, summary (international conference)
PACAP-PAC1 signaling pathway regulates internalization of serotonin 2A receptor in a protein kinase C and beta-arrestin2 dependent manner
A. Hayata, K. Moriguchi, N. Encho, N. Shintani, A. Baba, H. Hashimoto
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 17 p. 83-83 2014/06 Research paper, summary (international conference)
The balance between BMP and TGF-beta signaling at an early stage steers serotonergic differentiation from ES cells
Atsushi Yamasaki, Atsushi Kasai, Akihiro Toi, Maki Kurita, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 p. 181P-181P 2014 Research paper, summary (international conference)
Altered expression of PACAP in the mPFC in depression-like states induced by chronic social defeat stress
Keisuke Hazama, Atsushi Kasai, Sumiaki Ogawa, Atsuko Hayata, Norihito Shintani, Akemiti Baba, Hitoshi Hashimoto
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 124 p. 187P-187P 2014 Research paper, summary (international conference)
PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) PLAYS SIGNIFICANT ROLES IN DENDRITIC SPINE FORMATION AND MORPHOLOGY
S. Higashi, K. Seiriki, A. Hayata, K. Ogata, N. Shintani, A. Kasai, D. Vaudry, A. Baba, H. Hashimoto
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 51 p. S226-S226 2013/11 Research paper, summary (international conference)
ANALYSIS OF PACAP SIGNALING-MEDIATED RECEPTOR INTERNALIZATION USING THE HALOTAG SYSTEM
A. Hayata, N. Encho, K. Moriguchi, T. Fujino, N. Shintani, A. Kasai, A. Baba, H. Hashimoto
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 51 p. S203-S203 2013/11 Research paper, summary (international conference)
Psychiatric implications of PACAP-dependent signaling
Hitoshi Hashimoto, Kaoru Seiriki, Katsuya Ogata, Keisuke Hazama, Norihito Shintani, Atsuko Hayata-Takano, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 48 p. S162-S162 2012/11 Research paper, summary (international conference)
Selective involvement of prostanoid receptor CRTH2 in depression-like behaviors
N. Shintani, Y. Onaka, R. Takenaga, T. Kanoh, R. Haba, A. Hayata, H. Hirai, K. Nagata, M. Nakamura, A. Baba, H. Hashimoto
JOURNAL OF NEUROCHEMISTRY Vol. 123 p. 73-73 2012/10 Research paper, summary (international conference)
Pituitary adenylate cyclase-activating polypeptide (PACAP) plays significant roles in mental function and neuronal development
A. Hayata, K. Seiriki, M. Tajiri, K. Ogata, N. Shintani, A. Baba, H. Hashimoto
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 15 p. 202-203 2012/06 Research paper, summary (international conference)
HPGB, an inhibitor for mitochondrial fusion, promotes mitophagy
Shintaro Higashi, Norihito Shintani, Kazuhiko Katagi, Kazuya Ikeda, Mai Koumoto, Natsumi Hiraki, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 118 p. 74P-74P 2012 Research paper, summary (international conference)
脳とくすり セロトニンシグナルと発達障害
早田 敦子, 橋本 均, 大阪大学大学院大阪大学・金沢大学・浜松医科大学連合小児発達学研究科附属子どものこころの分子統御機構研究センター
脳21 Vol. 14 No. 2 p. 175-179 2011/04 Article, review, commentary, editorial, etc. (scientific journal)
Publisher: (株)金芳堂PACAP is implicated in regulation of neurite and dendritic spine formation
Katsuya Ogata, Atsuko Hayata, Kaoru Seiriki, Keisuke Hazama, Hisae Momosaki, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 115 p. 93P-93P 2011 Research paper, summary (international conference)
The roles of pancreatic PACAP in cerulein-induced pancreatitis
Yusuke Sakurai, Ken-ichi Hamagami, Akihiro Arimori, Hiroaki Inoue, Norihito Shintani, Naoko Higuchi, Kazuya Ikeda, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 42 No. 3 p. 311-311 2010/11 Research paper, summary (international conference)
Altered emotional and cognitive function in PACAP-deficient mice: a novel animal model for psychiatric disorder
Norihito Shintani, Hitoshi Hashimoto, Atsuko Hayata, Katsuya Ogata, Ryota Haba, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 42 No. 3 p. 278-279 2010/11 Research paper, summary (international conference)
PACAP plays a crucial role in the stress-induced activation of HPA-axis
Atsuko Hayata, Norihito Shintani, Yoko Saida, Michiya Kakuda, Naohiro Tsukiyama, Katsuya Ogata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 42 No. 3 p. 301-302 2010/11 Research paper, summary (international conference)
Identification of a novel signaling cascade specifically involved in the light-induced phase advance of circadian rhythm by using PACAP knockout mice
Michiyoshi Hatanaka, Norihito Shintani, Chihiro Kawaguchi, Reiko Nakamura, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF MOLECULAR NEUROSCIENCE Vol. 42 No. 3 p. 297-298 2010/11 Research paper, summary (international conference)
HPGB is a novel factor that inhibits mitochondrial fusion and membrane potential
Hikaru Kamemato, Kazuya Ikeda, Norihito Shintani, Shintaro Higashi, Mai Koumoto, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 p. 124P-124P 2010 Research paper, summary (international conference)
5-HT2 agonist DOI-induced psychomotor behavior in PACAP heterozygous knockout (PACAP+/-) mice
Keisuke Hazama, Kazuki Uetsuki, Minako Taziri, Katsuya Ogata, Atsuko Hayata, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 p. 226P-226P 2010 Research paper, summary (international conference)
Involvement of novel prostanoid receptor CRTH2 in LPS-induced sickness behaviors
Ryota Haba, Norihito Shintani, Hyper Wang, Yusuke Onaka, Atsuko Hayata, Hitoshi Hashimoto, Hiroyuki Hirai, Kinya Nagata, Masataka Nakamura, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 p. 63P-63P 2010 Research paper, summary (international conference)
Generation of highly purified serotonergic neurons from mouse ES cells
Takeshi Shimada, Hitoshi Hashimoto, Kikuko Shinohara, Atsushi Yamasaki, Yoshihiro Takai, Norihito Shintani, Atsuko Hayata, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 p. 92P-92P 2010 Research paper, summary (international conference)
Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration behavior
Ryota Haba, Norihito Shintani, Hyper Wang, Yusuke Onaka, Atsuko Hayata, Hitoshi Hashimoto, Hiroyuki Hirai, Kinya Nagata, Masataka Nakamura, Akemichi Baba
NEUROSCIENCE RESEARCH Vol. 68 p. E80-E81 2010 Research paper, summary (international conference)
Interaction between genetic and non-genetic factors modulates psychomotor behaviors in PACAP-heterozygous knockout mice
Keisuke Hazama, Atsuko Hayata, Kazuki Uetsuki, Katsuya Ogata, Minako Taziri, Hisae Momosaki, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba
NEUROSCIENCE RESEARCH Vol. 68 p. E82-E82 2010 Research paper, summary (international conference)
Cerulein-induced pancreatitis in PACAP knockout mice
Yusuke Sakurai, Akihiro Arimori, Hiroaki Inoue, Norihito Shintani, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba
JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 112 p. 166P-166P 2010 Research paper, summary (international conference)
Inverse association between S408n variation of human casein kinase1 epsilon gene and circadian rhythm sleep disorders
T Ebisawa, A Takano, M Uchiyama, N Kajimura, K Mishima, Y Inoue, N Ozaki, M Okawa, K Takahashi, Y Isojima
SLEEP Vol. 28 p. A60-A60 2005 Research paper, summary (international conference)
Maternal hypothyroidism during the fetal and neonatal periods causes behavioral abnormalities in mouse offspring
Mima S., Hayata-Takano A., Tomita S., Iwahashi M., Ishida K., Matsumaru D., Nakanishi T., Takuma K.
第98回日本薬理学会年会 2025/03/17
Prenatal PGD2-DP1 signaling activation exhibits behavioral abnormalities associated with autism-like mental/behavioral disorders in mice
2024/07/25
Treatment for attention-deficit hyperactivity disorder (ADHD) drug normalizes AIS length abnormality along with hyperactivity in pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice.
Misaki Iwahashi, Takeshi Yoshimura, Wakana Harigai, Kazuhiro Takuma, Hitoshi Hashimoto, Taiichi Katayama, Atsuko Hayata-Takano
2024/05/23
Overexpression of vasoactive intestinal peptide receptor 2 in neurons causes abnormal dendritic morphology in the prefrontal cortex and cognitive impairment
Ami Ono, Daichi Koan, Satoshi Asano, Tatsunori Miyaoka, Lu Chen, Shinsaku Nakagawa, Atsuko Hayata-Takano, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Kotaro Tanimoto, Yukio Ago
2024/05/23
The effects of PACAP-PAC1 signal blockade in the medial prefrontal cortex on repeated social defeat stress mice
竹下黎,早田敦子,豊田博紀,新谷勇介,生田学登,髙崎一朗,栗原崇,田熊一敞,加藤隆史,橋本均
第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会 2023/12/16
Abnormality of axon initial segment in mice with attention-deficit hyperactivity disorder (ADHD)-like behavior and that recovery by the drug for ADHD.
岩橋美咲, 吉村武, 張替若菜, 田熊一敞, 橋本均, 片山泰一, 早田敦子
第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会 2023/12/16
低分子PAC１受容体遮断薬〜ストレス関連障害の新たな薬物治療に向けて〜
早田敦子
第５３回日本神経精神薬理学会 2023/09/08
胎生期PGD2-DP1シグナル活性化と神経発達症
早田敦子
第66回日本神経化学会大会 2023/07/07
PACAP受容体PAC1の低分子遮断薬の抗うつ効果と関連する脳領域の解析
早田敦子, 新谷勇介, 山野結衣, 生田学登, 竹下黎, 田熊一敞, 髙崎一朗, 栗原崇, 橋本均
BPCNPNPPP2022 2022/11/04
Fast and lasting antidepressant-like effect of small molecule PACAP receptor PAC1 antagonist
Yusuke Shintani, Atsuko Hayata-Takano, Yui Yamano, Manato Ikuta, Rei Takeshita, Kenichiro Murata, Ichiro Takasaki, Takashi Kurihara, Hitoshi Hashimoto
2022/11/01
A single oral administration of small-molecule PAC1 antagonist attenuates repeated stress-induced depressive-like behaviors in mice
Manato Ikuta, Atsuko Hayata-Takano, Yusuke Shintani, Yui Yamano, Rei Takeshita, Kenichiro Murata, Ichiro Takasaki, Takashi Kurihara, Hitoshi Hashimoto
VPAC ISBAP2022 2022/10/30
Chemogenetic inhibition of PACAP neurons projecting to the mPFC exerts antidepressant-like effects
VPAC ISBAP2022 2022/10/30
新規PACAP受容体PAC1遮断薬による即効性、持続性の抗うつ作用
新谷勇介, 早田敦子, 山野結衣, 生田学登, 竹下黎, 髙﨑一朗, 栗原崇, 橋本均
第95回日本薬理学会年会 2022/03/07
慢性社会的敗北ストレスモデルマウスにおける新規低分子性PACAP受容体PAC1遮断薬の行動薬理学研究
新谷勇介, 早田敦子, 山野結衣, 生田学登, 竹下黎, 髙﨑一朗, 栗原崇, 橋本均
第16回GPCR研究会 2021/11/19
胎児期におけるPGD2シグナル活性化による社会性行動や神経細胞形態への影響
菊池泰河, 早田敦子, 毛利育子, 橘雅弥, 谷池雅子, 橋本均
第140回日本薬理学会近畿部会 2021/11/13
Relationship between PER2 phosphorylation and stress response
2021/11/05
Overexpression of VIPR2 in neurons causes defects in dendritic growth and cognitive impairment
Tatsunori Miyaoka, Lu Chen, Mei Yamada, Daichi Koan, Satoshi Asano, Kenji Ishimoto, Shinsaku Nakagawa, Atsuko Hayata, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Yukio Ago
AsCNP2021 2021/10/22
Maternal separation with early weaning induced anxiety-like behavior and morphological changes in mouse mPFC neurons.
2021/07/15
VPAC2受容体の制御する細胞遊走メカニズム
山坂 美紗, 浅野 智志, 早田 敦子, 中澤 敬信, 橋本 均, Waschek James, 吾郷 由希夫
日本薬学会第141年会 2021/03/26
脳神経細胞でのVPAC2受容体の過剰発現は認知機能障害を引き起こす
古庵 大地, 今戸 瑛二, 浅野 智志, Chen Lu, 宮岡 辰典, 山田 めゐ, 石本 憲司, 中川 晋作, 早田 敦子, 中澤 敬信, 原田 彰宏, 橋本 均, Waschek James, 吾郷 由希夫
日本薬学会第141年会 2021/03/26
PACAP attenuates 5-HTR2A mediated hallucinations.
Shintani Y, Hayata-Takano A, Moriguchi K, Hashimoto H
CINP2020 2021/02/28
睡眠相前進を示すPER2点変異マウスは慢性ストレスに抵抗性をもつ
早田 敦子, 山脇 洋輔, 今村 聖路, 内匠 透
NPBPPP2020 2020/08/23
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome
Baba M., Yokoyama K., Seiriki K., Matsumura K., Kondo M., Yamamoto K., Kasai A., Ago Y., Nagayasu K., Hayata-Takano A., Yamaguchi S., Mori D., Ozaki N., Yamamoto T., Takuma K., Hashimoto R., Hashimoto H. and Nakazawa T
第93回日本薬理学会年会 2020/03/18
Modeling VIPR2 Linkages to Schizophrenia in Mice and Discovering Antipsychotic Medications
Ago Y, Chen L, Hayata-Takano A, Nakazawa T, Nakagawa S, Hashimoto H.
第10回武田科学振興財団 薬科学シンポジウム 2020/01/25
Analysis of PACAP signaling for functional synapse formation in the hippocampal neurons
Hayata-Takano A., Kijima H, Kamo T, Seiriki K, Shintani Y, Nakazawa T, Hashimoto H.
the Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium 2019/11/05
Differential regulation of PACAP-PAC1 signaling by two isoforms of β-arrestin
Shintani Y., Hayata-Takano A., Moriguchi K., Kijima H, Kikuchi T, Hashimoto H.
the Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium 2019/11/04
PACAP Increases Functional Synapses In The Primary Hippocampal Neurons
Hayata-Takano A., Kijima H, Shintani Y, Nakazawa T, Hashimoto H.
AsCNP2019 2019/10
神経ペプチドPACAPの機能的シナプス調節機構の解析
貴島春衣、早田敦子、新谷勇介、中澤敬信、橋本均
次世代を担う創薬・医療薬理シンポジウム2019 2019/08/31
G-protein-coupled receptors interaction with β-arrestin affects their localization at the primary cilium
Shikada S, Miyoshi K, Hayata A, Yoshimura T, Han S, Amano G, Takamura H, Katayama T.
NEURO2019 2019/07
PACAP-provoked PAC1 receptor signaling and internalization through two isoform of β-arrestins dependent mechanisms
Shintani Y., Hayata-Takano A., Moriguchi K., Hashimoto H.
NEURO2019 2019/07
Mice neonatally treated with the VPAC2 receptor agonist present cognitive dysfunction specifically reverted by clozapine
Takeuchi S, Yamauchi R, Kawanai T, Miyaoka T, Chen L, Hayata-takano A, Waschek JA, Nakazawa T, Takuma K, Nakagawa S, Hashimoto H, Ago Y.
NEURO2019 2019/07
Prostaglandin D2 modulates neuronal morphological development via activation of DP1 receptor
Hayata-Takano A, Mohri I, Okuda K, Tachibana M, Kikuchi T, Shintani Y, Nakazawa T, Taniike M, HashimotoH
NEURO2019 2019/07
Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes
Hagihara H, Shoji H, Kohno T, Hayata-Takano A, Tamada K, Hori K, Tatsukawa T, Shibutani M,他30名
IBANGS2019 2019/05
ゲノムコピー数変異に着目した統合失調症の創薬研究
吾郷由希夫, 早田敦子, 中澤敬信, 田熊一敞, 橋本 均
日本薬学会 第139年会 2019/03
マウス新生仔へのプロスタグランジンD2受容体DP1作動薬による神経細胞の形態や行動への影響
早田 敦子
第48回日本神経精神薬理学会 2018/11/16
Role of the VPAC2 receptor overactivation implicated in schizophrenia susceptibility
Ago Y, Hayata-Takano A, Nakazawa T, Takuma K, Hashimoto H
Oral Neuroscience 2018/10/07
統合失調症の発症脆弱性因子としてのVPAC2受容体過活性化による大脳皮質神経発達異常と認知機能障害の発現
竹内修斗、山内良介、河内琢也、早田敦子、Waschek James、橋本均、吾郷由希夫
第61回日本神経化学会 2018/09
An interaction between PAC1 receptor and serotonin 2A receptor involved in receptor trafficking and signal transduction
Shintani Y, Hayata-Takano A, Moriguchi K, Encho N, Hashimoto H
WCP2018 2018/07/05
PACAP-provoked PAC1 receptor signaling and internalization through two isoform of β-arrestins dependent mechanisms
Shintani Y, Hayata-Takano A, Moriguchi K, Hashimoto H
International GPCR symposium 2018/06/30
Involvement of miR-132 in PACAP-dependent morphological changes of dendritic spines
HAYATA ATSUKO
CINP2018 2018/06/18
VPAC2受容体欠損マウスは恐怖記憶の消失障害と前頭前野における樹状突起の形態異常を示す
山内良介、吾郷由希夫、河内琢也、竹内修斗、早田敦子、Waschek James、橋本均
日本薬学会 第138年会 2018/03
Modeling VIPR2 linkages to schizophrenia in mice
Ago Y, Hayata-Takano A, Rajbhandari A, Fanselow M, Hashimoto H, Waschek JA
The 13th International Symposium on VIP, PACAP and Related Peptides, 2017/12/06
プロスタグランジンD2受容体DP1を介したマウス神経細胞の形態変化の解析
奥田健太, 早田敦子, 毛利育子, 新谷勇介, 加茂俊彦, 中澤敬信, 谷池雅子, 橋本均
第132回 日本薬理学会 近畿部会 2017/11/24
β-アレスチンを介する PACAP-PAC1 シグナルの解析
新谷勇介, 早田敦子, 橋本均
第131回 日本薬理学会 近畿部会 2017/06/30
VPAC2 receptor inhibits neurite outgrowth and branching of cortical neurons by a PKA-dependent mechanism
Hashimoto H, Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Waschek JA
Neuroscience 2016 2016/11
神経細胞の成熟におけるPACAPとBDNFの役割
早田 敦子
第59回日本神経化学会大会 2016/09/08
miRNAを介したPACAPによる樹状突起スパイン形成機構
加茂 俊彦, 早田 敦子, 勢力 薫, 尾形 勝弥, 中澤 敬信, 永安 一樹, 笠井 淳司, 新谷 紀人, 橋本 均
第45回日本神経精神薬理学会 2016/09
Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfunction in mice
Ago Y, Hayata A, Kawanai T, Yamauchi R, Waschek J, Hashimoto H
The 30th CINP World Congress of Neuropsychopharmacology, 2015/09
PACAP-PAC1 signaling pathway regulates internalization of serotonin 2A receptor in a PKC and b-arrestin2 dependent manner
A. Hayata, K Moriguchi, N. Encho, K. Moriguchi, N. Shintani, A. Baba, H. Hashimoto
CINP2014 2014/06/22
胎生期PGD2-DP1シグナル活性化はマウスの自閉症様の精神行動異常を引き起こす
村田拳一朗, 早田敦子, 菊池泰河, 岩橋美咲, 毛利育子, 橘雅弥, 田熊一敞, 片山泰一, 谷池雅子, 橋本均
第50回日本脳科学会 2023/12/03
PAC1受容体拮抗薬を用いた抗うつ・抗不安薬
栗原崇, 髙﨑一朗, 橋本均, 早田敦子, 新谷勇介
特許7049637号
