顔写真

PHOTO

Kayama Hisako
香山　尚子
Kayama Hisako
香山　尚子
Institutional repository
Institute for Advanced Co-Creation Studies，Associate Professor
Institutional repository

Research History 1

  1. - Present
    Osaka University

Education 1

  1. 大阪大学大学院　医学系研究科

    2007/04 - 2009/03

Professional Memberships 1

  1. THE JAPANESE SOCIETY FOR IMMUNOLOGY

Research Areas 1

  1. Life sciences / Immunology /

Awards 2

  1. 第15回日本免疫学会研究研究奨励賞

    2020/12

  2. 令和2年度大阪大学賞若手研究員部門

    2020/12

Papers 89

  1. Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression.

    Akikazu Harada, Yoshiaki Yasumizu, Takeshi Harada, Katsumi Fumoto, Akira Sato, Natsumi Maehara, Ryota Sada, Shinji Matsumoto, Takashi Nishina, Kiyoshi Takeda, Eiichi Morii, Hisako Kayama, Akira Kikuchi

    Nature communications　Vol. 16　No. 1　p. 3653-3653　2025/04/17　Research paper (scientific journal)

  2. Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion

    Ryota Mori, Takayuki Ogino, Mari Murakami, Hisako Kayama, Daisuke Okuzaki, Atsuyo Ikeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Hiroki Ikeuchi, Kiyoshi Takeda, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi

    JOURNAL OF GASTROENTEROLOGY　2025/03/29　Research paper (scientific journal)

  3. Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion.

    Ryota Mori, Takayuki Ogino, Mari Murakami, Hisako Kayama, Daisuke Okuzaki, Atsuyo Ikeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Hiroki Ikeuchi, Kiyoshi Takeda, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi

    Journal of gastroenterology　2025/03/29　Research paper (scientific journal)

  4. Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism.

    Mayu Yagita-Sakamaki, Takayoshi Ito, Taiki Sakaguchi, Shuichi Shimma, Bo Li, Daisuke Okuzaki, Daisuke Motooka, Shota Nakamura, Koji Hase, Eiichiro Fukusaki, Akira Kikuchi, Takashi Nagasawa, Atsushi Kumanogoh, Kiyoshi Takeda, Hisako Kayama

    International immunology　2025/01/08　Research paper (scientific journal)

  5. Periportal macrophages protect against commensal-driven liver inflammation

    Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii

    Nature　Vol. 629　No. 8013　p. 901-909　2024/04/24　Research paper (scientific journal)

  6. Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.

    Yuki Ichimura, Risa Konishi, Miwako Shobo, Ryota Tanaka, Noriko Kubota, Hisako Kayama, Kiyoshi Takeda, Toshifumi Nomura, Manabu Fujimoto, Naoko Okiyama

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 16　2024/04/16　Research paper (scientific journal)

  7. The UDP-glucose/P2Y14 receptor axis promotes eosinophil-dependent large intestinal inflammation.

    Li Liu, Takayoshi Ito, Bo Li, Haruka Tani, Daisuke Okuzaki, Daisuke Motooka, Hazuki Miyazaki, Takayuki Ogino, Shota Nakamura, Kiyoshi Takeda, Hisako Kayama

    International immunology　2023/12/18　Research paper (scientific journal)

  8. 高脂肪食によるディスバイオシスが前立腺癌に及ぼす影響の解明

    松下 慎, 藤田 和利, 林 拓自, 香山 尚子, 元岡 大祐, 長谷 拓明, 山本 顕生, 植村 俊彦, 山道 岳, 冨山 栄輔, 洪 陽子, 加藤 大悟, 波多野 浩士, 河嶋 厚成, 植村 元秀, 野島 聡, 今村 亮一, 辻川 和丈, 中村 昇太, 竹田 潔, 森井 英一, 野々村 祝夫

    泌尿器外科　Vol. 36　No. 8　p. 895-896　2023/08　Part of collection (book)

    Publisher: 医学図書出版(株)

  9. TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses.

    Thanyakorn Chalalai, Naganori Kamiyama, Benjawan Saechue, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Astri Dewayani, Yasuhiro Soga, Yomei Kagoshima, Supanuch Ekronarongchai, Ryu Okumura, Hisako Kayama, Kiyoshi Takeda, Takashi Kobayashi

    Biochemical and biophysical research communications　Vol. 669　p. 103-112　2023/05/27　Research paper (scientific journal)

  10. Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of patients with rheumatoid arthritis.

    Takuro Nii, Yuichi Maeda, Daisuke Motooka, Mariko Naito, Yuki Matsumoto, Takao Ogawa, Eri Oguro-Igashira, Toshihiro Kishikawa, Makoto Yamashita, Satoshi Koizumi, Takashi Kurakawa, Ryu Okumura, Hisako Kayama, Mari Murakami, Taiki Sakaguchi, Bhabatosh Das, Shota Nakamura, Yukinori Okada, Atsushi Kumanogoh, Kiyoshi Takeda

    Annals of the rheumatic diseases　Vol. 82　No. 5　p. 621-629　2023/01/10　Research paper (scientific journal)

  11. 免疫・アレルギー・炎症 クローン病においてTh1/Th17応答を惹起する腸内環境因子とそのメカニズム

    香山 尚子, 大竹 由利子, 飯島 英樹, 竹田 潔

    リンパ学　Vol. 45　No. 2　p. 96-99　2022/12

    Publisher: 日本リンパ学会

  12. 代謝制御による疾患治療戦略 炎症性腸疾患における腸内細菌依存的な免疫代謝異常

    香山 尚子, 大竹 由利子, 飯島 英樹, 竹田 潔

    日本臨床免疫学会総会プログラム・抄録集　Vol. 50回　p. 50-50　2022/10

    Publisher: (一社)日本臨床免疫学会

  13. 腸内細菌による前立腺癌増殖制御メカニズムの解明

    松下 慎, 藤田 和利, 林 拓自, 香山 尚子, 元岡 大祐, 長谷 拓明, 神宮司 健太郎, 山本 顕生, 植村 俊彦, 山道 岳, 冨山 栄輔, 洪 陽子, 加藤 大悟, 波多野 浩士, 河嶋 厚成, 植村 元秀, 今村 亮一, 辻川 和丈, 中村 昇太, 竹田 潔, 野々村 祝夫

    泌尿器外科　Vol. 35　No. 8　p. 858-859　2022/08

    Publisher: 医学図書出版(株)

  14. 腸内細菌による前立腺癌増殖制御メカニズムの解明

    松下 慎, 藤田 和利, 林 拓自, 香山 尚子, 元岡 大祐, 長谷 拓明, 神宮司 健太郎, 山本 顕生, 植村 俊彦, 山道 岳, 冨山 栄輔, 洪 陽子, 加藤 大悟, 波多野 浩士, 河嶋 厚成, 植村 元秀, 今村 亮一, 辻川 和丈, 中村 昇太, 竹田 潔, 野々村 祝夫

    泌尿器外科　Vol. 35　No. 8　p. 858-859　2022/08

    Publisher: 医学図書出版(株)

  15. Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response.

    Yuriko Otake-Kasamoto, Hisako Kayama, Toshihiro Kishikawa, Shinichiro Shinzaki, Taku Tashiro, Takahiro Amano, Mizuki Tani, Takeo Yoshihara, Bo Li, Haruka Tani, Li Liu, Akio Hayashi, Daisuke Okuzaki, Daisuke Motooka, Shota Nakamura, Yukinori Okada, Hideki Iijima, Kiyoshi Takeda, Tetsuo Takehara

    The Journal of experimental medicine　Vol. 219　No. 7　2022/07/04　Research paper (scientific journal)

  16. An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia.

    Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Kiyoshi Takeda, Akihiro Tsuboi, Keiichi Ozono

    Cancer immunology, immunotherapy : CII　2022/06/14　Research paper (scientific journal)

  17. High-fat diet promotes prostate cancer growth through histamine signaling.

    Makoto Matsushita, Kazutoshi Fujita, Koji Hatano, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Akinaru Yamamoto, Toshihiko Uemura, Gaku Yamamichi, Eisuke Tomiyama, Yoko Koh, Taigo Kato, Atsunari Kawashima, Motohide Uemura, Satoshi Nojima, Ryoichi Imamura, Aysha Mubeen, George J Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda, Eiichi Morii, Norio Nonomura

    International journal of cancer　Vol. 151　No. 4　p. 623-636　2022/04/11　Research paper (scientific journal)

  18. Pyruvate enhances oral tolerance via GPR31

    Qizhi Liu, Eiji Umemoto, Naoki Morita, Hisako Kayama, Yoshihiro Baba, Tomohiro Kurosaki, Ryu Okumura, Kiyoshi Takeda

    International Immunology　2022/03/18　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  19. Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.

    Siddhika Pareek, Xenia Sanchenkova, Taiki Sakaguchi, Mari Murakami, Ryu Okumura, Hisako Kayama, Saya Kawauchi, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Tadamitsu Kishimoto, Kiyoshi Takeda

    Genes to cells : devoted to molecular & cellular mechanisms　Vol. 27　No. 4　p. 243-253　2022/01/25　Research paper (scientific journal)

  20. The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.

    Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, Takayuki Ogino, Shih-Han Tsai, Yoki Furuta, Masato Muneta, Shota Nakamura, Eiichiro Fukusaki, Kimiko Yamamoto, Hideo Yagita, Hisako Kayama, Kiyoshi Takeda

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 39　2021/09/28　Research paper (scientific journal)

  21. Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier

    Sotaro Ozaka, Akira Sonoda, Shimpei Ariki, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Kanako Ito, Yoko Kudo, Mizuki Minata, Benjawan Saechue, Astri Dewayani, Thanyakorn Chalalai, Yasuhiro Soga, Yuya Takahashi, Chiaki Fukuda, Kazuhiro Mizukami, Ryu Okumura, Hisako Kayama, Kazunari Murakami, Kiyoshi Takeda, Takashi Kobayashi

    Genes to Cells　2021/08/17　Research paper (scientific journal)

    Publisher: Wiley

  22. Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling.

    Makoto Matsushita, Kazutoshi Fujita, Takuji Hayashi, Hisako Kayama, Daisuke Motooka, Hiroaki Hase, Kentaro Jingushi, Gaku Yamamichi, Satoru Yumiba, Eisuke Tomiyama, Yoko Koh, Yujiro Hayashi, Kosuke Nakano, Cong Wang, Yu Ishizuya, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Maria D C Rodriguez Pena, Jennifer B Gordetsky, George J Netto, Kazutake Tsujikawa, Shota Nakamura, Kiyoshi Takeda, Norio Nonomura

    Cancer research　Vol. 81　No. 15　p. 4014-4026　2021/05/26　Research paper (scientific journal)

  23. Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis.

    Naoko Okiyama, Yuki Ichimura, Miwako Shobo, Ryota Tanaka, Noriko Kubota, Akimasa Saito, Yosuke Ishitsuka, Rei Watanabe, Yasuhiro Fujisawa, Yoshiyuki Nakamura, Akihiro Murakami, Hisako Kayama, Kiyoshi Takeda, Manabu Fujimoto

    Annals of the rheumatic diseases　Vol. 80　No. 9　p. 1201-1208　2021/04/02　Research paper (scientific journal)

  24. Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites.

    Hisako Kayama, Kiyoshi Takeda

    European journal of immunology　Vol. 50　No. 7　p. 921-931　2020/07　Research paper (scientific journal)

  25. Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.

    Asuka Yasueda, Hisako Kayama, Michiko Murohashi, Junichi Nishimura, Koji Wakame, Ken-Ichi Komatsu, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Toru Kitagawa, Kiyoshi Takeda, Toshinori Ito, Yuichiro Doki, Hidetoshi Eguchi, Shigeomi Shimizu, Tsunekazu Mizushima

    Scientific reports　Vol. 10　No. 1　p. 9972-9972　2020/06/19　Research paper (scientific journal)

  26. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

    Taiki Sakaguchi, Ryu Okumura, Chisato Ono, Daisuke Okuzaki, Takafumi Kawai, Yoshifumi Okochi, Natsuko Tanimura, Mari Murakami, Hisako Kayama, Eiji Umemoto, Hidetaka Kioka, Tomohito Ohtani, Yasushi Sakata, Kensuke Miyake, Yasushi Okamura, Yoshihiro Baba, Kiyoshi Takeda

    Cell reports　Vol. 31　No. 10　p. 107755-107755　2020/06/09　Research paper (scientific journal)

  27. Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.

    Atsuyo Ikeda, Takayuki Ogino, Hisako Kayama, Daisuke Okuzaki, Junichi Nishimura, Shiki Fujino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Kiyoshi Takeda, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

    Cancer immunology research　Vol. 8　No. 6　p. 724-731　2020/06　Research paper (scientific journal)

  28. Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.

    Hisako Kayama, Ryu Okumura, Kiyoshi Takeda

    Annual review of immunology　Vol. 38　p. 23-48　2020/04/26　Research paper (scientific journal)

  29. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.

    Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Erumbi S Rangarajan, Kelly McKevitt, Amanda P Beck, Cody B Jackson, Gogce Crynen, Angelos Oikonomopoulos, Precious N Lacey, Gustavo J Martinez, Tina Izard, Robin G Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T Abreu, Daniel W Hommes, Sergei B Koralov, Kiyoshi Takeda, Mark S Sundrud

    Immunity　Vol. 52　No. 3　p. 571-571　2020/03/17

  30. Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi.

    Siddhika Pareek, Takashi Kurakawa, Bhabatosh Das, Daisuke Motooka, Shuuichi Nakaya, Temsunaro Rongsen-Chandola, Nidhi Goyal, Hisako Kayama, Dylan Dodd, Ryu Okumura, Yuichi Maeda, Kosuke Fujimoto, Takuro Nii, Takao Ogawa, Tetsuya Iida, Nita Bhandari, Toshiyuki Kida, Shota Nakamura, G Balakrish Nair, Kiyoshi Takeda

    NPJ biofilms and microbiomes　Vol. 5　p. 37-37　2019/12　Research paper (scientific journal)

  31. BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway.

    Hisako Kayama, Haruka Tani, Shoko Kitada, Anunya Opasawatchai, Ryu Okumura, Daisuke Motooka, Shota Nakamura, Kiyoshi Takeda

    International immunology　Vol. 31　No. 6　p. 371-383　2019/05/21　Research paper (scientific journal)

  32. Recasting the Tissue-Resident Lymphocyte in Celiac Disease.

    Hisako Kayama, Kiyoshi Takeda

    Immunity　Vol. 50　No. 3　p. 549-551　2019/03/19　Research paper (scientific journal)

  33. GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.

    Naoki Morita, Eiji Umemoto, Setsuko Fujita, Akio Hayashi, Junichi Kikuta, Ikuo Kimura, Takeshi Haneda, Toshio Imai, Asuka Inoue, Hitomi Mimuro, Yuichi Maeda, Hisako Kayama, Ryu Okumura, Junken Aoki, Nobuhiko Okada, Toshiyuki Kida, Masaru Ishii, Ryusuke Nabeshima, Kiyoshi Takeda

    Nature　Vol. 566　No. 7742　p. 110-114　2019/02　Research paper (scientific journal)

  34. Mucosal regulatory system for balanced immunity in the gut

    Hisako Kayama, Kiyoshi Takeda

    Mucosal Vaccines: Innovation for Preventing Infectious Diseases　p. 247-254　2019/01/01　Part of collection (book)

    Publisher: Elsevier

  35. Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.

    Yuki Sekido, Yoshiaki Yasumizu, Junichi Nishimura, Hisako Kayama, Hiroshi Matsuno, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori, Kiyoshi Takeda, Naganari Ohkura, Shimon Sakaguchi, Tsunekazu Mizushima

    Digestion　Vol. 99　No. 3　p. 194-204　2019　Research paper (scientific journal)

  36. The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis.

    Tadafumi Fukata, Tsunekazu Mizushima, Junichi Nishimura, Daisuke Okuzaki, Xin Wu, Haruka Hirose, Yuhki Yokoyama, Yui Kubota, Kazuya Nagata, Naoto Tsujimura, Akira Inoue, Norikatsu Miyoshi, Naotsugu Haraguchi, Hidekazu Takahashi, Taishi Hata, Chu Matsuda, Hisako Kayama, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

    Molecular therapy. Nucleic acids　Vol. 12　p. 658-671　2018/09/07　Research paper (scientific journal)

  37. Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

    Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 33　p. 8418-8423　2018/08/14　Research paper (scientific journal)

  38. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.

    Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Erumbi S Rangarajan, Kelly McKevitt, Amanda P Beck, Cody B Jackson, Gogce Crynen, Angelos Oikonomopoulos, Precious N Lacey, Gustavo J Martinez, Tina Izard, Robin G Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T Abreu, Daniel W Hommes, Sergei B Koralov, Kiyoshi Takeda, Mark S Sundrud

    Immunity　Vol. 47　No. 6　p. 1182-1196　2017/12/19　Research paper (scientific journal)

  39. Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.

    Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

    Cell reports　Vol. 21　No. 7　p. 1824-1838　2017/11/14　Research paper (scientific journal)

  40. CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis.

    Hiroshi Matsuno, Hisako Kayama, Junichi Nishimura, Yuki Sekido, Hideki Osawa, Soumik Barman, Takayuki Ogino, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Motoi Uchino, Hiroki Ikeuchi, Yuichiro Doki, Masaki Mori, Kiyoshi Takeda, Tsunekazu Mizushima

    Inflammatory bowel diseases　Vol. 23　No. 9　p. 1524-1534　2017/09　Research paper (scientific journal)

  41. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.

    Shoko Kitada, Hisako Kayama, Daisuke Okuzaki, Ritsuko Koga, Masao Kobayashi, Yasunobu Arima, Atsushi Kumanogoh, Masaaki Murakami, Masahito Ikawa, Kiyoshi Takeda

    The Journal of experimental medicine　Vol. 214　No. 5　p. 1313-1331　2017/05/01　Research paper (scientific journal)

  42. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

    Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita, Kiyoshi Takeda

    Mucosal Immunol　Vol. 10　No. 2　p. 446-459　2017/03　Research paper (scientific journal)

  43. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186

    Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita, Kiyoshi Takeda

    MUCOSAL IMMUNOLOGY　Vol. 10　No. 2　p. 446-459　2017/03　Research paper (scientific journal)

  44. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine

    Yoki Furuta, Shih-Han Tsai, Makoto Kinoshita, Kosuke Fujimoto, Ryu Okumura, Eiji Umemoto, Yosuke Kurashima, Hiroshi Kiyono, Hisako Kayama, Kiyoshi Takeda

    PLOS ONE　Vol. 12　No. 2　2017/02　Research paper (scientific journal)

  45. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

    Yuichi Maeda, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, Yoshinaga Ito, Kazuyoshi Gotoh, Keiji Hirota, Masato Matsushita, Yoki Furuta, Masashi Narazaki, Noriko Sakaguchi, Hisako Kayama, Shota Nakamura, Tetsuya Iida, Yukihiko Saeki, Atsushi Kumanogoh, Shimon Sakaguchi, Kiyoshi Takeda

    ARTHRITIS & RHEUMATOLOGY　Vol. 68　No. 11　p. 2646-2661　2016/11　Research paper (scientific journal)

  46. Identification of a human intestinal myeloid cell subset that regulates gut homeostasis

    Soumik Barman, Hisako Kayama, Daisuke Okuzaki, Takayuki Ogino, Hideki Osawa, Hiroshi Matsuno, Tsunekazu Mizushima, Masaki Mori, Junichi Nishimura, Kiyoshi Takeda

    INTERNATIONAL IMMUNOLOGY　Vol. 28　No. 11　p. 533-545　2016/11　Research paper (scientific journal)

  47. IL-10-producing lung interstitial macrophages prevent neutrophilic asthma

    Hideo Kawano, Hisako Kayama, Takekuni Nakama, Takashi Hashimoto, Eiji Umemoto, Kiyoshi Takeda

    INTERNATIONAL IMMUNOLOGY　Vol. 28　No. 10　p. 489-501　2016/10　Research paper (scientific journal)

  48. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

    Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano, Kiyoshi Takeda

    NATURE　Vol. 532　No. 7597　p. 117-+　2016/04　Research paper (scientific journal)

  49. Functions of innate immune cells and commensal bacteria in gut homeostasis

    Hisako Kayama, Kiyoshi Takeda

    JOURNAL OF BIOCHEMISTRY　Vol. 159　No. 2　p. 141-149　2016/02

  50. Regulation of the human gut homeostasis by anti-inflammatory CD14+ CD163high CD160high myeloid cells

    Hisako Kayama, Kiyoshi Takeda

    Japanese Journal of Clinical Immunology　Vol. 39　No. 5　p. 441-447　2016　Research paper (scientific journal)

    Publisher: Japan Society for Clinical Immunology

  51. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta (vol 283, pg 12468, 2008)

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 37　p. 22446-22446　2015/09

  52. The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis

    Ichino Chinen, Taisuke Nakahama, Akihiro Kimura, Nam T. Nguyen, Hiroshi Takemori, Ayako Kumagai, Hisako Kayama, Kiyoshi Takeda, Soyoung Lee, Hamza Hanieh, Barry Ripley, David Millrine, Praveen K. Dubey, Kishan K. Nyati, Yoshiaki Fujii-Kuriyama, Kamal Chowdhury, Tadamitsu Kishimoto

    International Immunology　Vol. 27　No. 8　p. 405-415　2015/08/01　Research paper (scientific journal)

    Publisher: Oxford University Press

  53. The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis

    Ichino Chinen, Taisuke Nakahama, Akihiro Kimura, Nam T. Nguyen, Hiroshi Takemori, Ayako Kumagai, Hisako Kayama, Kiyoshi Takeda, Soyoung Lee, Hamza Hanieh, Barry Ripley, David Millrine, Praveen K. Dubey, Kishan K. Nyati, Yoshiaki Fujii-Kuriyama, Kamal Chowdhury, Tadamitsu Kishimoto

    INTERNATIONAL IMMUNOLOGY　Vol. 27　No. 8　p. 405-415　2015/08　Research paper (scientific journal)

  54. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis

    Akira Sato, Hisako Kayama, Kensaku Shojima, Shinji Matsumoto, Hirofumi Koyama, Yasuhiro Minami, Satoshi Nojima, Eiichi Morii, Hiroaki Honda, Kiyoshi Takeda, Akira Kikuchi

    SCIENTIFIC REPORTS　Vol. 5　2015/06　Research paper (scientific journal)

  55. The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells

    Shih Han Tsai, Makoto Kinoshita, Takashi Kusu, Hisako Kayama, Ryu Okumura, Kayo Ikeda, Yosuke Shimada, Akira Takeda, Soichiro Yoshikawa, Kazushige Obata-Ninomiya, Yosuke Kurashima, Shintaro Sato, Eiji Umemoto, Hiroshi Kiyono, Hajime Karasuyama, Kiyoshi Takeda

    Immunity　Vol. 42　No. 2　p. 279-293　2015/02/17　Research paper (scientific journal)

    Publisher: Cell Press

  56. The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells

    Shih Han Tsai, Makoto Kinoshita, Takashi Kusu, Hisako Kayama, Ryu Okumura, Kayo Ikeda, Yosuke Shimada, Akira Takeda, Soichiro Yoshikawa, Kazushige Obata-Ninomiya, Yosuke Kurashima, Shintaro Sato, Eiji Umemoto, Hiroshi Kiyono, Hajime Karasuyama, Kiyoshi Takeda

    IMMUNITY　Vol. 42　No. 2　p. 279-293　2015/02　Research paper (scientific journal)

  57. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta (vol 283, pg 12468, 2008)

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 8　p. 4815-4815　2015/02

  58. Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells

    Kayama Hisako, Takeda Kiyoshi

    Inflammation and Regeneration　Vol. 35　No. 1　p. 28-41　2015

    Publisher: The Japanese Society of Inflammation and Regeneration

  59. 専門スタディーフォーラム3-1 MΦ，樹状細胞 食餌鉄依存的な腸管CX3CR1high制御性ミエロイド細胞維持機構

    香山 尚子, 香山 雅子, 竹田 潔

    日本臨床免疫学会会誌　Vol. 38　No. 4　p. 270-270　2015

    Publisher: The Japan Society for Clinical Immunology

  60. Regulation of immune responses by ATP-hydrolyzing ecto-enzymes

    Takeda Kiyoshi, Tsai Shih Han, Kayama Hisako

    Inflammation and Regeneration　Vol. 35　No. 4　p. 172-177　2015

    Publisher: The Japanese Society of Inflammation and Regeneration

  61. Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

    Masanori Matsumoto, Akemi Baba, Takafumi Yokota, Hiroyoshi Nishikawa, Yasuyuki Ohkawa, Hisako Kayama, Axel Kallies, Stephen L. Nutt, Shimon Sakaguchi, Kiyoshi Takeda, Tomohiro Kurosaki, Yoshihiro Baba

    IMMUNITY　Vol. 41　No. 6　p. 1040-1051　2014/12　Research paper (scientific journal)

  62. Generation of colonic IgA-secreting cells in the caecal patch

    Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima, Osamu Yoshie, Masahiro Fukuzawa, Hiroshi Kiyono, Sidonia Fagarasan, Tetsuya Iida, Masaru Ishii, Kiyoshi Takeda

    NATURE COMMUNICATIONS　Vol. 5　2014/04　Research paper (scientific journal)

  63. Polysaccharide A of Bacteroides fragilis: Actions on Dendritic Cells and T Cells

    Hisako Kayama, Kiyoshi Takeda

    MOLECULAR CELL　Vol. 54　No. 2　p. 206-207　2014/04

  64. Combination of Tumor Necrosis Factor alpha and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo

    Kazuhiro Yokota, Kojiro Sato, Takashi Miyazaki, Hideki Kitaura, Hisako Kayama, Fumihiko Miyoshi, Yasuto Araki, Yuji Akiyama, Kiyoshi Takeda, Toshihide Mimura

    ARTHRITIS & RHEUMATOLOGY　Vol. 66　No. 1　p. 121-129　2014/01　Research paper (scientific journal)

  65. Increased Th17-Inducing Activity of CD14(+) CD163(low) Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn's Disease

    Takayuki Ogino, Junichi Nishimura, Soumik Barman, Hisako Kayama, Satoshi Uematsu, Daisuke Okuzaki, Hideki Osawa, Naotsugu Haraguchi, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori

    GASTROENTEROLOGY　Vol. 145　No. 6　p. 1380-+　2013/12　Research paper (scientific journal)

  66. Regulation of intestinal homeostasis by innate immune cells.

    Kayama H, Nishimura J, Takeda K

    Immune network　Vol. 13　No. 6　p. 227-234　2013/12

  67. Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

    Yosuke Shimada, Makoto Kinoshita, Kazuo Harada, Masafumi Mizutani, Kazunori Masahata, Hisako Kayama, Kiyoshi Takeda

    PLOS ONE　Vol. 8　No. 11　2013/11　Research paper (scientific journal)

  68. Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5 ' Capped 2 '-O Unmethylated RNA

    Taishi Kimura, Hiroshi Katoh, Hisako Kayama, Hiroyuki Saiga, Megumi Okuyama, Toru Okamoto, Eiji Umemoto, Yoshiharu Matsuura, Masahiro Yamamoto, Kiyoshi Takeda

    JOURNAL OF VIROLOGY　Vol. 87　No. 18　p. 9997-10003　2013/09　Research paper (scientific journal)

  69. Recent advances in understanding the role of innate immunity in the pathogenesis of inflammatory bowel disease

    Hisako Kayama, Kiyoshi Takeda

    Journal of Japanese Society of Gastroenterology　Vol. 110　No. 5　p. 741-752　2013/05

  70. CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock

    Naganori Kamiyama, Masahiro Yamamoto, Hiroyuki Saiga, Ji Su Ma, Jun Ohshima, Sakaaki Machimura, Miwa Sasai, Taishi Kimura, Yoshiyasu Ueda, Hisako Kayama, Kiyoshi Takeda

    PLoS ONE　Vol. 8　No. 2　2013/02/07　Research paper (scientific journal)

  71. Ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

    Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H, Serada S, Fujimoto M, Takeda K, Naka T, Yamashita T

    Cell Death and Disease　Vol. 4　No. 7　2013

  72. Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

    Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda

    JOURNAL OF IMMUNOLOGY　Vol. 190　No. 2　p. 774-783　2013/01　Research paper (scientific journal)

  73. Regulation of intestinal homeostasis by innate and adaptive immunity

    Hisako Kayama, Kiyoshi Takeda

    INTERNATIONAL IMMUNOLOGY　Vol. 24　No. 11　p. 673-680　2012/11

  74. Dietary Folic Acid Promotes Survival of Foxp3(+) Regulatory T Cells in the Colon

    Makoto Kinoshita, Hisako Kayama, Takashi Kusu, Tomoyuki Yamaguchi, Jun Kunisawa, Hiroshi Kiyono, Shimon Sakaguchi, Kiyoshi Takeda

    JOURNAL OF IMMUNOLOGY　Vol. 189　No. 6　p. 2869-2878　2012/09　Research paper (scientific journal)

  75. A Cluster of Interferon-gamma-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

    Masahiro Yamamoto, Megumi Okuyama, Ji Su Ma, Taishi Kimura, Naganori Kamiyama, Hiroyuki Saiga, Jun Ohshima, Miwa Sasai, Hisako Kayama, Toru Okamoto, David C. S. Huang, Dominique Soldati-Favre, Kyoji Horie, Junji Takeda, Kiyoshi Takeda

    IMMUNITY　Vol. 37　No. 2　p. 302-313　2012/08　Research paper (scientific journal)

  76. Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

    Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda

    PLOS PATHOGENS　Vol. 8　No. 5　2012/05　Research paper (scientific journal)

  77. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon

    Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M. Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda

    PLoS Pathogens　Vol. 8　No. 5　2012/05　Research paper (scientific journal)

  78. Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis

    Hisako Kayama, Yoshiyasu Ueda, Yukihisa Sawa, Seong Gyu Jeon, Ji Su Ma, Ryu Okumura, Atsuko Kubo, Masaru Ishii, Taku Okazaki, Masaaki Murakami, Masahiro Yamamoto, Hideo Yagita, Kiyoshi Takeda

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 109　No. 13　p. 5010-5015　2012/03　Research paper (scientific journal)

  79. W7-3  制御性ミエロイド細胞による炎症性腸疾患抑制機構

    香山 尚子, 竹田 潔

    日本臨床免疫学会会誌　Vol. 35　No. 4　p. 315a-315a　2012

    Publisher: The Japan Society for Clinical Immunology

  80. The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

    Kazushiro Takata, Makoto Kinoshita, Tatsusada Okuno, Masayuki Moriya, Tohru Kohda, Josephe A. Honorat, Tomoyuki Sugimoto, Atsushi Kumanogoh, Hisako Kayama, Kiyoshi Takeda, Saburo Sakoda, Yuji Nakatsuji

    PLOS ONE　Vol. 6　No. 11　2011/11　Research paper (scientific journal)

  81. ATF6 beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18

    Masahiro Yamamoto, Ji Su Ma, Christina Mueller, Naganori Kamiyama, Hiroyuki Saiga, Emi Kubo, Taishi Kimura, Toru Okamoto, Megumi Okuyama, Hisako Kayama, Kisaburo Nagamune, Seiji Takashima, Yoshiharu Matsuura, Dominique Soldati-Favre, Kiyoshi Takeda

    JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 208　No. 7　p. 1533-1546　2011/07　Research paper (scientific journal)

  82. Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

    Yoshiyasu Ueda, Hisako Kayama, Seong Gyu Jeon, Takashi Kusu, Yoshitaka Isaka, Hiromi Rakugi, Masahiro Yamamoto, Kiyoshi Takeda

    INTERNATIONAL IMMUNOLOGY　Vol. 22　No. 12　p. 953-962　2010/12　Research paper (scientific journal)

  83. The innate immune response to Trypanosoma cruzi infection

    Hisako Kayama, Kiyoshi Takeda

    MICROBES AND INFECTION　Vol. 12　No. 7　p. 511-517　2010/07

  84. A novel in vivo inducible dendritic cell ablation model in mice

    Megumi Okuyama, Hisako Kayama, Koji Atarashi, Hiroyuki Saiga, Taishi Kimura, Ari Waisman, Masahiro Yamamoto, Kiyoshi Takeda

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 397　No. 3　p. 559-563　2010/07　Research paper (scientific journal)

  85. A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3

    Masahiro Yamamoto, Daron M. Standley, Seiji Takashima, Hiroyuki Saiga, Megumi Okuyama, Hisako Kayama, Emi Kubo, Hiroshi Ito, Mutsumi Takaura, Tadashi Matsuda, Dominique Soldati-Favre, Kiyoshi Takeda

    JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 206　No. 12　p. 2747-2760　2009/11　Research paper (scientific journal)

  86. NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection

    Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W. Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

    PLOS PATHOGENS　Vol. 5　No. 7　2009/07　Research paper (scientific journal)

  87. Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.

    Hideaki Morishita, Fumiji Saito, Hisako Kayama, Koji Atarashi, Hirotaka Kuwata, Masahiro Yamamoto, Kiyoshi Takeda

    International immunology　Vol. 21　No. 4　p. 457-65　2009/04　Research paper (scientific journal)

  88. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta

    Hisako Kayama, Vladimir R. Ramirez-Carrozzi, Masahiro Yamamoto, Taketoshi Mizutani, Hirotaka Kuwata, Hideo Iba, Makoto Matsumoto, Kenya Honda, Stephen T. Smale, Kiyoshi Takeda

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 18　p. 12468-12477　2008/05　Research paper (scientific journal)

  89. Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor

    Junichi Nishimura, Hiroyuki Saiga, Shintaro Sato, Megumi Okuyama, Hisako Kayama, Hirotaka Kuwata, Sohkichi Matsumoto, Toshirou Nishida, Yoshiki Sawa, Shizuo Akira, Yasunobu Yoshikai, Masahiro Yamamoto, Kiyoshi Takeda

    JOURNAL OF IMMUNOLOGY　Vol. 180　No. 6　p. 4032-4039　2008/03　Research paper (scientific journal)

Misc. 19

  1. Identification of the fibroblast subsets expressing Wnt5a in AOM/DSS model of colitis-associated colorectal cancer

    原田武志, 原田昭和, 香山尚子, 佐藤朗, 菊池章

    日本分子生物学会年会プログラム・要旨集(Web)　Vol. 44th　2021

  2. 高脂肪食摂取前立腺癌マウスモデルを用いた腸内細菌による代謝産物を介した癌増殖メカニズムの解明

    松下慎, 藤田和利, 藤田和利, 林拓自, 香山尚子, 元岡大祐, 長谷拓明, 神宮司健太郎, 山道岳, 弓場覚, 冨山栄輔, 洪陽子, 林裕次郎, 加藤大悟, 波多野浩士, 河嶋厚成, 植村元秀, 今村亮一, 辻川和丈, 中村昇太, 竹田潔, 野々村祝夫

    日本アンドロロジー学会総会記事　Vol. 40th　2021

  3. Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus.

    Yuki Sekido, Junichi Nishimura, Kazuhiro Nakano, Takeaki Osu, Cheryl-Emiliane T Chow, Hiroshi Matsuno, Takayuki Ogino, Shiki Fujino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hisako Kayama, Masaki Mori, Yuichiro Doki, Kiyoshi Takeda, Motoi Uchino, Hiroki Ikeuchi, Tsunekazu Mizushima

    Scientific reports　Vol. 10　No. 1　p. 2988-2988　2020/02/19

  4. The roles of macrophages in the gut homeostasis

    Vol. 259　No. 5　p. 441-445　2016/10/29

    Publisher: 医歯薬出版

  5. Dietary iron and transcription factor Spi-C regulate gut homeostasis through maintenance of CX(3)CR1(high) CD11b(+) CD11c(+) cells

    H. Kayama, M. Kohyama, H. Arase, K. Takeda

    EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 46　p. 470-470　2016/08　Research paper, summary (international conference)

  6. The effect of ATP metabolism on cancer

    Vol. 258　No. 5　p. 451-454　2016/07/30

    Publisher: 医歯薬出版

  7. Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析

    佐藤 朗, 香山 尚子, 庄嶋 健作, 松本 真司, 小山 浩史, 南 康博, 野島 聡, 森井 英一, 本田 浩章, 竹田 潔, 菊池 章

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [1P0170]-[1P0170]　2015/12

    Publisher: (公社)日本生化学会

  8. Regulation of intestinal immune responses

    Vol. 64　No. 4　p. 326-331　2015/10

    Publisher: 科学評論社

  9. Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析

    佐藤 朗, 香山 尚子, 庄嶋 健作, 松本 真司, 小山 浩史, 南 康博, 野島 聡, 森井 英一, 本田 浩章, 竹田 潔, 菊池 章

    日本生化学会大会プログラム・講演要旨集　Vol. 87回　p. [2T09p-07]　2014/10

    Publisher: (公社)日本生化学会

  10. Induction of type 1 regulatory T cells by Bifidobacterium breve

    Vol. 62　No. 2　p. 134-139　2014/08

    Publisher: 科学評論社

  11. 免疫応答の負の制御:免疫恒常性の維持と疾患治療への応用 自然免疫細胞による腸管免疫制御

    香山尚子, 西村潤一, 竹田潔

    細胞工学　Vol. 32　No. 12　p. 1205-1210　2013/11/22

  12. Regulation of intestinal homeostasis by innate immune cells

    Vol. 246　No. 11　p. 954-959　2013/09/14

    Publisher: 医歯薬出版

  13. 自然免疫系を標的とした炎症性腸疾患の制御 (特集 最新の免疫学 : 自然免疫・獲得免疫)

    梅本 英司, 香山 尚子, 竹田 潔

    医薬ジャーナル　Vol. 49　No. 2　p. 79-84　2013/02

    Publisher: 医薬ジャーナル社

  14. Wnt5aノックアウトマウスにおける腸管炎症の抑制

    佐藤朗, 庄嶋健作, 香山尚子, 小山浩史, 竹田潔, 菊池章

    日本分子生物学会年会プログラム・要旨集(Web)　Vol. 36th　2013

  15. Regulation of Intestinal Inflammation by Regulatory Myeloid (Mreg) Cell

    Vol. 31　No. 11　p. 1215-1219　2012

    Publisher: 学研メディカル秀潤社 ; 1982-

  16. 食事抗原による腸管免疫活性化が多発性硬化症のリスクファクターとなる

    木下 允, 高田 和城, 奥野 龍禎, 香山 尚子, 竹田 潔, 熊ノ郷 淳, 佐古田 三郎, 中辻 裕司

    日本神経免疫学会学術集会抄録集　Vol. 23回　p. 110-110　2011/09

    Publisher: 日本神経免疫学会

  17. The role of intestinal macrophages in mucosal homeostasis

    Cell technology　Vol. 30　No. 4　p. 361-365　2011

    Publisher: 学研メディカル秀潤社

  18. 腸管免疫と炎症性腸疾患 (特集 腸管免疫と腸疾患)

    香山 尚子, 竹田 潔

    アレルギ-・免疫　Vol. 17　No. 7　p. 1182-1186　2010/07

    Publisher: 医薬ジャ-ナル社

  19. Epigenetic regulation of TLR signaling

    Clinical immunology & allergology　Vol. 51　No. 3　p. 217-224　2009/03

    Publisher: 科学評論社

Industrial Property Rights 3

  1. 腸内細菌数低減剤

  2. 炎症性腸疾患を検査する方法

  3. 炎症性腸疾患治療用組成物

Institutional Repository 5

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Group 1 innate lymphoid cells and inflammatory macrophages exacerbate fibrosis in creeping fat through IFN-γ secretion

    Mori Ryota, Ogino Takayuki, Murakami Mari, Kayama Hisako, Okuzaki Daisuke, Ikeda Atsuyo, Sekido Yuki, Hata Tsuyoshi, Hamabe Atsushi, Takahashi Hidekazu, Miyoshi Norikatsu, Uemura Mamoru, Ikeuchi Hiroki, Takeda Kiyoshi, Mizushima Tsunekazu, Doki Yuichiro, Eguchi Hidetoshi

    Journal of Gastroenterology　2025/03/29

  2. Periportal macrophages protect against commensal-driven liver inflammation

    Miyamoto Yu, Kikuta Junichi, Matsui Takahiro, Hasegawa Tetsuo, Fujii Kentaro, Okuzaki Daisuke, Liu Yu Chen, Yoshioka Takuya, Seno Shigeto, Motooka Daisuke, Uchida Yutaka, Yamashita Erika, Kobayashi Shogo, Eguchi Hidetoshi, Morii Eiichi, Tryggvason Karl, Shichita Takashi, Kayama Hisako, Atarashi Koji, Kunisawa Jun, Honda Kenya, Takeda Kiyoshi, Ishii Masaru

    Nature　Vol. 629　p. 901-909　2024/05/23

  3. The UDP-glucose/P2Y14 receptor axis promotes eosinophil-dependent large intestinal inflammation

    Liu Li, Ito Takayoshi, Li Bo, Tani Haruka, Okuzaki Daisuke, Motooka Daisuke, Miyazaki Hazuki, Ogino Takayuki, Nakamura Shota, Takeda Kiyoshi, Kayama Hisako

    International Immunology　Vol. 36　No. 4　p. 155-166　2024/04/04

  4. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

    Kitada Shoko, Kayama Hisako, Okuzaki Daisuke, Koga Ritsuko, Kobayashi Masao, Arima Yasunobu, Kumanogoh Atsushi, Murakami Masaaki, Ikawa Masahito, Takeda Kiyoshi

    Journal of Experimental Medicine　Vol. 214　No. 5　p. 1313-1331　2017/05/29

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