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Kayama Hisako

香山　尚子

Institute for Advanced Co-Creation Studies, Associate Professor

Education

  • 2007/04 - 2009/03, 大阪大学大学院, 医学系研究科

Research History

  • - Present, Osaka University

Research Areas

  • Life sciences, Immunology

Professional Memberships

  • THE JAPANESE SOCIETY FOR IMMUNOLOGY

Papers

  • The UDP-glucose/P2Y14 receptor axis promotes eosinophil-dependent large intestinal inflammation., Li Liu,Takayoshi Ito,Bo Li,Haruka Tani,Daisuke Okuzaki,Daisuke Motooka,Hazuki Miyazaki,Takayuki Ogino,Shota Nakamura,Kiyoshi Takeda,Hisako Kayama, International immunology, 2023/12/18
  • TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses., Thanyakorn Chalalai,Naganori Kamiyama,Benjawan Saechue,Nozomi Sachi,Sotaro Ozaka,Shimpei Ariki,Astri Dewayani,Yasuhiro Soga,Yomei Kagoshima,Supanuch Ekronarongchai,Ryu Okumura,Hisako Kayama,Kiyoshi Takeda,Takashi Kobayashi, Biochemical and biophysical research communications, Vol. 669, p. 103-112, 2023/05/27
  • Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of patients with rheumatoid arthritis., Takuro Nii,Yuichi Maeda,Daisuke Motooka,Mariko Naito,Yuki Matsumoto,Takao Ogawa,Eri Oguro-Igashira,Toshihiro Kishikawa,Makoto Yamashita,Satoshi Koizumi,Takashi Kurakawa,Ryu Okumura,Hisako Kayama,Mari Murakami,Taiki Sakaguchi,Bhabatosh Das,Shota Nakamura,Yukinori Okada,Atsushi Kumanogoh,Kiyoshi Takeda, Annals of the rheumatic diseases, Vol. 82, No. 5, p. 621-629, 2023/01/10
  • 免疫・アレルギー・炎症 クローン病においてTh1/Th17応答を惹起する腸内環境因子とそのメカニズム, 香山 尚子,大竹 由利子,飯島 英樹,竹田 潔, リンパ学, 日本リンパ学会, Vol. 45, No. 2, p. 96-99, 2022/12
  • 代謝制御による疾患治療戦略 炎症性腸疾患における腸内細菌依存的な免疫代謝異常, 香山 尚子,大竹 由利子,飯島 英樹,竹田 潔, 日本臨床免疫学会総会プログラム・抄録集, (一社)日本臨床免疫学会, Vol. 50回, p. 50-50, 2022/10
  • 腸内細菌による前立腺癌増殖制御メカニズムの解明, 松下 慎,藤田 和利,林 拓自,香山 尚子,元岡 大祐,長谷 拓明,神宮司 健太郎,山本 顕生,植村 俊彦,山道 岳,冨山 栄輔,洪 陽子,加藤 大悟,波多野 浩士,河嶋 厚成,植村 元秀,今村 亮一,辻川 和丈,中村 昇太,竹田 潔,野々村 祝夫, 泌尿器外科, 医学図書出版(株), Vol. 35, No. 8, p. 858-859, 2022/08
  • Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response., Yuriko Otake-Kasamoto,Hisako Kayama,Toshihiro Kishikawa,Shinichiro Shinzaki,Taku Tashiro,Takahiro Amano,Mizuki Tani,Takeo Yoshihara,Bo Li,Haruka Tani,Li Liu,Akio Hayashi,Daisuke Okuzaki,Daisuke Motooka,Shota Nakamura,Yukinori Okada,Hideki Iijima,Kiyoshi Takeda,Tetsuo Takehara, The Journal of experimental medicine, Vol. 219, No. 7, 2022/07/04
  • An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia., Natsuki Nakagawa,Yoshiko Hashii,Hisako Kayama,Ryu Okumura,Hiroko Nakajima,Hikaru Minagawa,Soyoko Morimoto,Fumihiro Fujiki,Jun Nakata,Toshiro Shirakawa,Takane Katayama,Kiyoshi Takeda,Akihiro Tsuboi,Keiichi Ozono, Cancer immunology, immunotherapy : CII, 2022/06/14
  • High-fat diet promotes prostate cancer growth through histamine signaling., Makoto Matsushita,Kazutoshi Fujita,Koji Hatano,Takuji Hayashi,Hisako Kayama,Daisuke Motooka,Hiroaki Hase,Akinaru Yamamoto,Toshihiko Uemura,Gaku Yamamichi,Eisuke Tomiyama,Yoko Koh,Taigo Kato,Atsunari Kawashima,Motohide Uemura,Satoshi Nojima,Ryoichi Imamura,Aysha Mubeen,George J Netto,Kazutake Tsujikawa,Shota Nakamura,Kiyoshi Takeda,Eiichi Morii,Norio Nonomura, International journal of cancer, Vol. 151, No. 4, p. 623-636, 2022/04/11
  • Pyruvate enhances oral tolerance via GPR31, Qizhi Liu,Eiji Umemoto,Naoki Morita,Hisako Kayama,Yoshihiro Baba,Tomohiro Kurosaki,Ryu Okumura,Kiyoshi Takeda, International Immunology, Oxford University Press (OUP), 2022/03/18
  • Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine., Siddhika Pareek,Xenia Sanchenkova,Taiki Sakaguchi,Mari Murakami,Ryu Okumura,Hisako Kayama,Saya Kawauchi,Daisuke Motooka,Shota Nakamura,Daisuke Okuzaki,Tadamitsu Kishimoto,Kiyoshi Takeda, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 27, No. 4, p. 243-253, 2022/01/25
  • The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells., Haruka Tani,Bo Li,Takashi Kusu,Ryu Okumura,Junichi Nishimura,Daisuke Okuzaki,Daisuke Motooka,Shoya Arakawa,Asuka Mori,Terukazu Yoshihara,Takayuki Ogino,Shih-Han Tsai,Yoki Furuta,Masato Muneta,Shota Nakamura,Eiichiro Fukusaki,Kimiko Yamamoto,Hideo Yagita,Hisako Kayama,Kiyoshi Takeda, Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 39, 2021/09/28
  • Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier, Sotaro Ozaka,Akira Sonoda,Shimpei Ariki,Naganori Kamiyama,Shinya Hidano,Nozomi Sachi,Kanako Ito,Yoko Kudo,Mizuki Minata,Benjawan Saechue,Astri Dewayani,Thanyakorn Chalalai,Yasuhiro Soga,Yuya Takahashi,Chiaki Fukuda,Kazuhiro Mizukami,Ryu Okumura,Hisako Kayama,Kazunari Murakami,Kiyoshi Takeda,Takashi Kobayashi, Genes to Cells, Wiley, 2021/08/17
  • Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling., Makoto Matsushita,Kazutoshi Fujita,Takuji Hayashi,Hisako Kayama,Daisuke Motooka,Hiroaki Hase,Kentaro Jingushi,Gaku Yamamichi,Satoru Yumiba,Eisuke Tomiyama,Yoko Koh,Yujiro Hayashi,Kosuke Nakano,Cong Wang,Yu Ishizuya,Taigo Kato,Koji Hatano,Atsunari Kawashima,Takeshi Ujike,Motohide Uemura,Ryoichi Imamura,Maria D C Rodriguez Pena,Jennifer B Gordetsky,George J Netto,Kazutake Tsujikawa,Shota Nakamura,Kiyoshi Takeda,Norio Nonomura, Cancer research, Vol. 81, No. 15, p. 4014-4026, 2021/05/26
  • Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis., Naoko Okiyama,Yuki Ichimura,Miwako Shobo,Ryota Tanaka,Noriko Kubota,Akimasa Saito,Yosuke Ishitsuka,Rei Watanabe,Yasuhiro Fujisawa,Yoshiyuki Nakamura,Akihiro Murakami,Hisako Kayama,Kiyoshi Takeda,Manabu Fujimoto, Annals of the rheumatic diseases, Vol. 80, No. 9, p. 1201-1208, 2021/04/02
  • Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites., Hisako Kayama,Kiyoshi Takeda, European journal of immunology, Vol. 50, No. 7, p. 921-931, 2020/07
  • Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages., Asuka Yasueda,Hisako Kayama,Michiko Murohashi,Junichi Nishimura,Koji Wakame,Ken-Ichi Komatsu,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Toru Kitagawa,Kiyoshi Takeda,Toshinori Ito,Yuichiro Doki,Hidetoshi Eguchi,Shigeomi Shimizu,Tsunekazu Mizushima, Scientific reports, Vol. 10, No. 1, p. 9972-9972, 2020/06/19
  • TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes., Taiki Sakaguchi,Ryu Okumura,Chisato Ono,Daisuke Okuzaki,Takafumi Kawai,Yoshifumi Okochi,Natsuko Tanimura,Mari Murakami,Hisako Kayama,Eiji Umemoto,Hidetaka Kioka,Tomohito Ohtani,Yasushi Sakata,Kensuke Miyake,Yasushi Okamura,Yoshihiro Baba,Kiyoshi Takeda, Cell reports, Vol. 31, No. 10, p. 107755-107755, 2020/06/09
  • Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer., Atsuyo Ikeda,Takayuki Ogino,Hisako Kayama,Daisuke Okuzaki,Junichi Nishimura,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hirofumi Yamamoto,Kiyoshi Takeda,Tsunekazu Mizushima,Masaki Mori,Yuichiro Doki, Cancer immunology research, Vol. 8, No. 6, p. 724-731, 2020/06
  • Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine., Hisako Kayama,Ryu Okumura,Kiyoshi Takeda, Annual review of immunology, Vol. 38, p. 23-48, 2020/04/26
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids., Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S Rangarajan,Kelly McKevitt,Amanda P Beck,Cody B Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N Lacey,Gustavo J Martinez,Tina Izard,Robin G Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T Abreu,Daniel W Hommes,Sergei B Koralov,Kiyoshi Takeda,Mark S Sundrud, Immunity, Vol. 52, No. 3, p. 571-571, 2020/03/17
  • Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi., Siddhika Pareek,Takashi Kurakawa,Bhabatosh Das,Daisuke Motooka,Shuuichi Nakaya,Temsunaro Rongsen-Chandola,Nidhi Goyal,Hisako Kayama,Dylan Dodd,Ryu Okumura,Yuichi Maeda,Kosuke Fujimoto,Takuro Nii,Takao Ogawa,Tetsuya Iida,Nita Bhandari,Toshiyuki Kida,Shota Nakamura,G Balakrish Nair,Kiyoshi Takeda, NPJ biofilms and microbiomes, Vol. 5, p. 37-37, 2019/12
  • BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway., Hisako Kayama,Haruka Tani,Shoko Kitada,Anunya Opasawatchai,Ryu Okumura,Daisuke Motooka,Shota Nakamura,Kiyoshi Takeda, International immunology, Vol. 31, No. 6, p. 371-383, 2019/05/21
  • Recasting the Tissue-Resident Lymphocyte in Celiac Disease., Hisako Kayama,Kiyoshi Takeda, Immunity, Vol. 50, No. 3, p. 549-551, 2019/03/19
  • GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites., Naoki Morita,Eiji Umemoto,Setsuko Fujita,Akio Hayashi,Junichi Kikuta,Ikuo Kimura,Takeshi Haneda,Toshio Imai,Asuka Inoue,Hitomi Mimuro,Yuichi Maeda,Hisako Kayama,Ryu Okumura,Junken Aoki,Nobuhiko Okada,Toshiyuki Kida,Masaru Ishii,Ryusuke Nabeshima,Kiyoshi Takeda, Nature, Vol. 566, No. 7742, p. 110-114, 2019/02
  • Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients., Yuki Sekido,Yoshiaki Yasumizu,Junichi Nishimura,Hisako Kayama,Hiroshi Matsuno,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Naganari Ohkura,Shimon Sakaguchi,Tsunekazu Mizushima, Digestion, Vol. 99, No. 3, p. 194-204, 2019
  • The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis., Tadafumi Fukata,Tsunekazu Mizushima,Junichi Nishimura,Daisuke Okuzaki,Xin Wu,Haruka Hirose,Yuhki Yokoyama,Yui Kubota,Kazuya Nagata,Naoto Tsujimura,Akira Inoue,Norikatsu Miyoshi,Naotsugu Haraguchi,Hidekazu Takahashi,Taishi Hata,Chu Matsuda,Hisako Kayama,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori,Hirofumi Yamamoto, Molecular therapy. Nucleic acids, Vol. 12, p. 658-671, 2018/09/07
  • Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles., Hisako Kayama,Masako Kohyama,Daisuke Okuzaki,Daisuke Motooka,Soumik Barman,Ryu Okumura,Masato Muneta,Katsuaki Hoshino,Izumi Sasaki,Wataru Ise,Hiroshi Matsuno,Junichi Nishimura,Tomohiro Kurosaki,Shota Nakamura,Hisashi Arase,Tsuneyasu Kaisho,Kiyoshi Takeda, Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 33, p. 8418-8423, 2018/08/14
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids., Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S Rangarajan,Kelly McKevitt,Amanda P Beck,Cody B Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N Lacey,Gustavo J Martinez,Tina Izard,Robin G Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T Abreu,Daniel W Hommes,Sergei B Koralov,Kiyoshi Takeda,Mark S Sundrud, Immunity, CELL PRESS, Vol. 47, No. 6, p. 1182-1196, 2017/12/19
  • Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells., Kayo Ikeda,Makoto Kinoshita,Hisako Kayama,Shushi Nagamori,Pornparn Kongpracha,Eiji Umemoto,Ryu Okumura,Takashi Kurakawa,Mari Murakami,Norihisa Mikami,Yasunori Shintani,Satoko Ueno,Ayatoshi Andou,Morihiro Ito,Hideki Tsumura,Koji Yasutomo,Keiichi Ozono,Seiji Takashima,Shimon Sakaguchi,Yoshikatsu Kanai,Kiyoshi Takeda, Cell reports, CELL PRESS, Vol. 21, No. 7, p. 1824-1838, 2017/11/14
  • CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis., Hiroshi Matsuno,Hisako Kayama,Junichi Nishimura,Yuki Sekido,Hideki Osawa,Soumik Barman,Takayuki Ogino,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Hirofumi Yamamoto,Motoi Uchino,Hiroki Ikeuchi,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Tsunekazu Mizushima, Inflammatory bowel diseases, LIPPINCOTT WILLIAMS & WILKINS, Vol. 23, No. 9, p. 1524-1534, 2017/09
  • BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection., Shoko Kitada,Hisako Kayama,Daisuke Okuzaki,Ritsuko Koga,Masao Kobayashi,Yasunobu Arima,Atsushi Kumanogoh,Masaaki Murakami,Masahito Ikawa,Kiyoshi Takeda, The Journal of experimental medicine, ROCKEFELLER UNIV PRESS, Vol. 214, No. 5, p. 1313-1331, 2017/05/01
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186., Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda, Mucosal Immunol, Vol. 10, No. 2, p. 446-459, 2017/03
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186, Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda, MUCOSAL IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 10, No. 2, p. 446-459, 2017/03
  • E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine, Yoki Furuta,Shih-Han Tsai,Makoto Kinoshita,Kosuke Fujimoto,Ryu Okumura,Eiji Umemoto,Yosuke Kurashima,Hiroshi Kiyono,Hisako Kayama,Kiyoshi Takeda, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 12, No. 2, 2017/02
  • Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine, Yuichi Maeda,Takashi Kurakawa,Eiji Umemoto,Daisuke Motooka,Yoshinaga Ito,Kazuyoshi Gotoh,Keiji Hirota,Masato Matsushita,Yoki Furuta,Masashi Narazaki,Noriko Sakaguchi,Hisako Kayama,Shota Nakamura,Tetsuya Iida,Yukihiko Saeki,Atsushi Kumanogoh,Shimon Sakaguchi,Kiyoshi Takeda, ARTHRITIS & RHEUMATOLOGY, WILEY, Vol. 68, No. 11, p. 2646-2661, 2016/11
  • Identification of a human intestinal myeloid cell subset that regulates gut homeostasis, Soumik Barman,Hisako Kayama,Daisuke Okuzaki,Takayuki Ogino,Hideki Osawa,Hiroshi Matsuno,Tsunekazu Mizushima,Masaki Mori,Junichi Nishimura,Kiyoshi Takeda, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 28, No. 11, p. 533-545, 2016/11
  • IL-10-producing lung interstitial macrophages prevent neutrophilic asthma, Hideo Kawano,Hisako Kayama,Takekuni Nakama,Takashi Hashimoto,Eiji Umemoto,Kiyoshi Takeda, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 28, No. 10, p. 489-501, 2016/10
  • Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia, Ryu Okumura,Takashi Kurakawa,Takashi Nakano,Hisako Kayama,Makoto Kinoshita,Daisuke Motooka,Kazuyoshi Gotoh,Taishi Kimura,Naganori Kamiyama,Takashi Kusu,Yoshiyasu Ueda,Hong Wu,Hideki Iijima,Soumik Barman,Hideki Osawa,Hiroshi Matsuno,Junichi Nishimura,Yusuke Ohba,Shota Nakamura,Tetsuya Iida,Masahiro Yamamoto,Eiji Umemoto,Koichi Sano,Kiyoshi Takeda, NATURE, NATURE PUBLISHING GROUP, Vol. 532, No. 7597, p. 117-+, 2016/04
  • Functions of innate immune cells and commensal bacteria in gut homeostasis, Hisako Kayama,Kiyoshi Takeda, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 159, No. 2, p. 141-149, 2016/02
  • Regulation of the human gut homeostasis by anti-inflammatory CD14+ CD163high CD160high myeloid cells, Hisako Kayama,Kiyoshi Takeda, Japanese Journal of Clinical Immunology, Japan Society for Clinical Immunology, Vol. 39, No. 5, p. 441-447, 2016
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta (vol 283, pg 12468, 2008), Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 37, p. 22446-22446, 2015/09
  • The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis, Ichino Chinen,Taisuke Nakahama,Akihiro Kimura,Nam T. Nguyen,Hiroshi Takemori,Ayako Kumagai,Hisako Kayama,Kiyoshi Takeda,Soyoung Lee,Hamza Hanieh,Barry Ripley,David Millrine,Praveen K. Dubey,Kishan K. Nyati,Yoshiaki Fujii-Kuriyama,Kamal Chowdhury,Tadamitsu Kishimoto, International Immunology, Oxford University Press, Vol. 27, No. 8, p. 405-415, 2015/08/01
  • The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis, Ichino Chinen,Taisuke Nakahama,Akihiro Kimura,Nam T. Nguyen,Hiroshi Takemori,Ayako Kumagai,Hisako Kayama,Kiyoshi Takeda,Soyoung Lee,Hamza Hanieh,Barry Ripley,David Millrine,Praveen K. Dubey,Kishan K. Nyati,Yoshiaki Fujii-Kuriyama,Kamal Chowdhury,Tadamitsu Kishimoto, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 27, No. 8, p. 405-415, 2015/08
  • The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis, Akira Sato,Hisako Kayama,Kensaku Shojima,Shinji Matsumoto,Hirofumi Koyama,Yasuhiro Minami,Satoshi Nojima,Eiichi Morii,Hiroaki Honda,Kiyoshi Takeda,Akira Kikuchi, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 5, 2015/06
  • The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells, Shih Han Tsai,Makoto Kinoshita,Takashi Kusu,Hisako Kayama,Ryu Okumura,Kayo Ikeda,Yosuke Shimada,Akira Takeda,Soichiro Yoshikawa,Kazushige Obata-Ninomiya,Yosuke Kurashima,Shintaro Sato,Eiji Umemoto,Hiroshi Kiyono,Hajime Karasuyama,Kiyoshi Takeda, Immunity, Cell Press, Vol. 42, No. 2, p. 279-293, 2015/02/17
  • The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells, Shih Han Tsai,Makoto Kinoshita,Takashi Kusu,Hisako Kayama,Ryu Okumura,Kayo Ikeda,Yosuke Shimada,Akira Takeda,Soichiro Yoshikawa,Kazushige Obata-Ninomiya,Yosuke Kurashima,Shintaro Sato,Eiji Umemoto,Hiroshi Kiyono,Hajime Karasuyama,Kiyoshi Takeda, IMMUNITY, CELL PRESS, Vol. 42, No. 2, p. 279-293, 2015/02
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta (vol 283, pg 12468, 2008), Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 8, p. 4815-4815, 2015/02
  • Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells, Kayama Hisako,Takeda Kiyoshi, Inflammation and Regeneration, The Japanese Society of Inflammation and Regeneration, Vol. 35, No. 1, p. 28-41, 2015
  • 専門スタディーフォーラム3-1 MΦ，樹状細胞 食餌鉄依存的な腸管CX<sub>3</sub>CR1<sup>high</sup>制御性ミエロイド細胞維持機構, 香山 尚子,香山 雅子,竹田 潔, 日本臨床免疫学会会誌, The Japan Society for Clinical Immunology, Vol. 38, No. 4, p. 270-270, 2015
  • Regulation of immune responses by ATP-hydrolyzing ecto-enzymes, Takeda Kiyoshi,Tsai Shih Han,Kayama Hisako, Inflammation and Regeneration, The Japanese Society of Inflammation and Regeneration, Vol. 35, No. 4, p. 172-177, 2015
  • Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation, Masanori Matsumoto,Akemi Baba,Takafumi Yokota,Hiroyoshi Nishikawa,Yasuyuki Ohkawa,Hisako Kayama,Axel Kallies,Stephen L. Nutt,Shimon Sakaguchi,Kiyoshi Takeda,Tomohiro Kurosaki,Yoshihiro Baba, IMMUNITY, CELL PRESS, Vol. 41, No. 6, p. 1040-1051, 2014/12
  • Generation of colonic IgA-secreting cells in the caecal patch, Kazunori Masahata,Eiji Umemoto,Hisako Kayama,Manato Kotani,Shota Nakamura,Takashi Kurakawa,Junichi Kikuta,Kazuyoshi Gotoh,Daisuke Motooka,Shintaro Sato,Tomonori Higuchi,Yoshihiro Baba,Tomohiro Kurosaki,Makoto Kinoshita,Yosuke Shimada,Taishi Kimura,Ryu Okumura,Akira Takeda,Masaru Tajima,Osamu Yoshie,Masahiro Fukuzawa,Hiroshi Kiyono,Sidonia Fagarasan,Tetsuya Iida,Masaru Ishii,Kiyoshi Takeda, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 5, 2014/04
  • Polysaccharide A of Bacteroides fragilis: Actions on Dendritic Cells and T Cells, Hisako Kayama,Kiyoshi Takeda, MOLECULAR CELL, CELL PRESS, Vol. 54, No. 2, p. 206-207, 2014/04
  • Combination of Tumor Necrosis Factor alpha and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo, Kazuhiro Yokota,Kojiro Sato,Takashi Miyazaki,Hideki Kitaura,Hisako Kayama,Fumihiko Miyoshi,Yasuto Araki,Yuji Akiyama,Kiyoshi Takeda,Toshihide Mimura, ARTHRITIS & RHEUMATOLOGY, WILEY-BLACKWELL, Vol. 66, No. 1, p. 121-129, 2014/01
  • Increased Th17-Inducing Activity of CD14(+) CD163(low) Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn's Disease, Takayuki Ogino,Junichi Nishimura,Soumik Barman,Hisako Kayama,Satoshi Uematsu,Daisuke Okuzaki,Hideki Osawa,Naotsugu Haraguchi,Mamoru Uemura,Taishi Hata,Ichiro Takemasa,Tsunekazu Mizushima,Hirofumi Yamamoto,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori, GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 145, No. 6, p. 1380-+, 2013/12
  • Regulation of intestinal homeostasis by innate immune cells., Kayama H,Nishimura J,Takeda K, Immune network, Vol. 13, No. 6, p. 227-234, 2013/12
  • Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon, Yosuke Shimada,Makoto Kinoshita,Kazuo Harada,Masafumi Mizutani,Kazunori Masahata,Hisako Kayama,Kiyoshi Takeda, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 8, No. 11, 2013/11
  • Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5 ' Capped 2 '-O Unmethylated RNA, Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuura,Masahiro Yamamoto,Kiyoshi Takeda, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 87, No. 18, p. 9997-10003, 2013/09
  • Recent advances in understanding the role of innate immunity in the pathogenesis of inflammatory bowel disease, Hisako Kayama,Kiyoshi Takeda, Journal of Japanese Society of Gastroenterology, Vol. 110, No. 5, p. 741-752, 2013/05
  • CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock, Naganori Kamiyama,Masahiro Yamamoto,Hiroyuki Saiga,Ji Su Ma,Jun Ohshima,Sakaaki Machimura,Miwa Sasai,Taishi Kimura,Yoshiyasu Ueda,Hisako Kayama,Kiyoshi Takeda, PLoS ONE, Vol. 8, No. 2, 2013/02/07
  • Ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury, Ishii H,Tanabe S,Ueno M,Kubo T,Kayama H,Serada S,Fujimoto M,Takeda K,Naka T,Yamashita T, Cell Death and Disease, Vol. 4, No. 7, 2013
  • Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine, Takashi Kusu,Hisako Kayama,Makoto Kinoshita,Seong Gyu Jeon,Yoshiyasu Ueda,Yoshiyuki Goto,Ryu Okumura,Hiroyuki Saiga,Takashi Kurakawa,Kayo Ikeda,Yuichi Maeda,Jun-ichi Nishimura,Yasunobu Arima,Koji Atarashi,Kenya Honda,Masaaki Murakami,Jun Kunisawa,Hiroshi Kiyono,Meinoshin Okumura,Masahiro Yamamoto,Kiyoshi Takeda, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, No. 2, p. 774-783, 2013/01
  • Regulation of intestinal homeostasis by innate and adaptive immunity, Hisako Kayama,Kiyoshi Takeda, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 24, No. 11, p. 673-680, 2012/11
  • Dietary Folic Acid Promotes Survival of Foxp3(+) Regulatory T Cells in the Colon, Makoto Kinoshita,Hisako Kayama,Takashi Kusu,Tomoyuki Yamaguchi,Jun Kunisawa,Hiroshi Kiyono,Shimon Sakaguchi,Kiyoshi Takeda, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 189, No. 6, p. 2869-2878, 2012/09
  • A Cluster of Interferon-gamma-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii, Masahiro Yamamoto,Megumi Okuyama,Ji Su Ma,Taishi Kimura,Naganori Kamiyama,Hiroyuki Saiga,Jun Ohshima,Miwa Sasai,Hisako Kayama,Toru Okamoto,David C. S. Huang,Dominique Soldati-Favre,Kyoji Horie,Junji Takeda,Kiyoshi Takeda, IMMUNITY, CELL PRESS, Vol. 37, No. 2, p. 302-313, 2012/08
  • Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon, Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 8, No. 5, 2012/05
  • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon, Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda, PLoS Pathogens, Vol. 8, No. 5, 2012/05
  • Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis, Hisako Kayama,Yoshiyasu Ueda,Yukihisa Sawa,Seong Gyu Jeon,Ji Su Ma,Ryu Okumura,Atsuko Kubo,Masaru Ishii,Taku Okazaki,Masaaki Murakami,Masahiro Yamamoto,Hideo Yagita,Kiyoshi Takeda, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 109, No. 13, p. 5010-5015, 2012/03
  • W7-3  制御性ミエロイド細胞による炎症性腸疾患抑制機構, 香山 尚子,竹田 潔, 日本臨床免疫学会会誌, The Japan Society for Clinical Immunology, Vol. 35, No. 4, p. 315a-315a, 2012
  • The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells, Kazushiro Takata,Makoto Kinoshita,Tatsusada Okuno,Masayuki Moriya,Tohru Kohda,Josephe A. Honorat,Tomoyuki Sugimoto,Atsushi Kumanogoh,Hisako Kayama,Kiyoshi Takeda,Saburo Sakoda,Yuji Nakatsuji, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 11, 2011/11
  • ATF6 beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18, Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 208, No. 7, p. 1533-1546, 2011/07
  • Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10, Yoshiyasu Ueda,Hisako Kayama,Seong Gyu Jeon,Takashi Kusu,Yoshitaka Isaka,Hiromi Rakugi,Masahiro Yamamoto,Kiyoshi Takeda, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 22, No. 12, p. 953-962, 2010/12
  • The innate immune response to Trypanosoma cruzi infection, Hisako Kayama,Kiyoshi Takeda, MICROBES AND INFECTION, ELSEVIER SCIENCE BV, Vol. 12, No. 7, p. 511-517, 2010/07
  • A novel in vivo inducible dendritic cell ablation model in mice, Megumi Okuyama,Hisako Kayama,Koji Atarashi,Hiroyuki Saiga,Taishi Kimura,Ari Waisman,Masahiro Yamamoto,Kiyoshi Takeda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 397, No. 3, p. 559-563, 2010/07
  • A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3, Masahiro Yamamoto,Daron M. Standley,Seiji Takashima,Hiroyuki Saiga,Megumi Okuyama,Hisako Kayama,Emi Kubo,Hiroshi Ito,Mutsumi Takaura,Tadashi Matsuda,Dominique Soldati-Favre,Kiyoshi Takeda, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 206, No. 12, p. 2747-2760, 2009/11
  • NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection, Hisako Kayama,Ritsuko Koga,Koji Atarashi,Megumi Okuyama,Taishi Kimura,Tak W. Mak,Satoshi Uematsu,Shizuo Akira,Hiroshi Takayanagi,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 7, 2009/07
  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses., Hideaki Morishita,Fumiji Saito,Hisako Kayama,Koji Atarashi,Hirotaka Kuwata,Masahiro Yamamoto,Kiyoshi Takeda, International immunology, Vol. 21, No. 4, p. 457-65, 2009/04
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta, Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 18, p. 12468-12477, 2008/05
  • Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor, Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 180, No. 6, p. 4032-4039, 2008/03

Misc.

  • Identification of the fibroblast subsets expressing Wnt5a in AOM/DSS model of colitis-associated colorectal cancer, 原田武志,原田昭和,香山尚子,佐藤朗,菊池章, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 44th, 2021
  • 高脂肪食摂取前立腺癌マウスモデルを用いた腸内細菌による代謝産物を介した癌増殖メカニズムの解明, 松下慎,藤田和利,藤田和利,林拓自,香山尚子,元岡大祐,長谷拓明,神宮司健太郎,山道岳,弓場覚,冨山栄輔,洪陽子,林裕次郎,加藤大悟,波多野浩士,河嶋厚成,植村元秀,今村亮一,辻川和丈,中村昇太,竹田潔,野々村祝夫, 日本アンドロロジー学会総会記事, Vol. 40th, 2021
  • Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus., Yuki Sekido,Junichi Nishimura,Kazuhiro Nakano,Takeaki Osu,Cheryl-Emiliane T Chow,Hiroshi Matsuno,Takayuki Ogino,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hisako Kayama,Masaki Mori,Yuichiro Doki,Kiyoshi Takeda,Motoi Uchino,Hiroki Ikeuchi,Tsunekazu Mizushima, Scientific reports, Vol. 10, No. 1, p. 2988-2988, 2020/02/19
  • The roles of macrophages in the gut homeostasis, Vol. 259, No. 5, p. 441-445, 2016/10/29
  • Dietary iron and transcription factor Spi-C regulate gut homeostasis through maintenance of CX(3)CR1(high) CD11b(+) CD11c(+) cells, H. Kayama,M. Kohyama,H. Arase,K. Takeda, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 46, p. 470-470, 2016/08
  • The effect of ATP metabolism on cancer, Vol. 258, No. 5, p. 451-454, 2016/07/30
  • Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析, 佐藤 朗,香山 尚子,庄嶋 健作,松本 真司,小山 浩史,南 康博,野島 聡,森井 英一,本田 浩章,竹田 潔,菊池 章, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, Vol. 88回・38回, p. [1P0170]-[1P0170], 2015/12
  • Regulation of intestinal immune responses, Vol. 64, No. 4, p. 326-331, 2015/10
  • Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析, 佐藤 朗,香山 尚子,庄嶋 健作,松本 真司,小山 浩史,南 康博,野島 聡,森井 英一,本田 浩章,竹田 潔,菊池 章, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 87回, p. [2T09p-07], 2014/10
  • Induction of type 1 regulatory T cells by Bifidobacterium breve, Vol. 62, No. 2, p. 134-139, 2014/08
  • 免疫応答の負の制御:免疫恒常性の維持と疾患治療への応用 自然免疫細胞による腸管免疫制御, 香山尚子,西村潤一,竹田潔, 細胞工学, Vol. 32, No. 12, p. 1205-1210, 2013/11/22
  • Regulation of intestinal homeostasis by innate immune cells, Vol. 246, No. 11, p. 954-959, 2013/09/14
  • 自然免疫系を標的とした炎症性腸疾患の制御 (特集 最新の免疫学 : 自然免疫・獲得免疫), 梅本 英司,香山 尚子,竹田 潔, 医薬ジャーナル, 医薬ジャーナル社, Vol. 49, No. 2, p. 79-84, 2013/02
  • Wnt5aノックアウトマウスにおける腸管炎症の抑制, 佐藤朗,庄嶋健作,香山尚子,小山浩史,竹田潔,菊池章, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 36th, 2013
  • Regulation of Intestinal Inflammation by Regulatory Myeloid (Mreg) Cell, Vol. 31, No. 11, p. 1215-1219, 2012
  • 食事抗原による腸管免疫活性化が多発性硬化症のリスクファクターとなる, 木下 允,高田 和城,奥野 龍禎,香山 尚子,竹田 潔,熊ノ郷 淳,佐古田 三郎,中辻 裕司, 日本神経免疫学会学術集会抄録集, 日本神経免疫学会, Vol. 23回, p. 110-110, 2011/09
  • The role of intestinal macrophages in mucosal homeostasis, Cell technology, Vol. 30, No. 4, p. 361-365, 2011
  • 腸管免疫と炎症性腸疾患 (特集 腸管免疫と腸疾患), 香山 尚子,竹田 潔, アレルギ-・免疫, 医薬ジャ-ナル社, Vol. 17, No. 7, p. 1182-1186, 2010/07
  • Epigenetic regulation of TLR signaling, Clinical immunology & allergology, Vol. 51, No. 3, p. 217-224, 2009/03

Industrial Property Rights

  • 腸内細菌数低減剤, 特願2021-50445
  • 炎症性腸疾患を検査する方法, 特願2021-48492
  • 炎症性腸疾患治療用組成物, 特願2021-48468

Awards

  • 第15回日本免疫学会研究研究奨励賞, 2020/12
  • 令和2年度大阪大学賞若手研究員部門, 2020/12