H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.

Shunsuke Kuroki, Ryo Maeda, Masashi Yano, Satsuki Kitano, Hitoshi Miyachi, Mikiko Fukuda, Yoichi Shinkai, Makoto Tachibana

Stem cell reports　Vol. 15　No. 2　p. 424-438　2020/08/11　Research paper (scientific journal)

TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.

Naoki Okashita, Shunsuke Kuroki, Ryo Maeda, Makoto Tachibana

Scientific reports　Vol. 9　No. 1　p. 13462-13462　2019/09/17　Research paper (scientific journal)

Role of epigenetic regulation in mammalian sex determination.

Shingo Miyawaki, Makoto Tachibana

Current topics in developmental biology　Vol. 134　p. 195-221　2019　Research paper (scientific journal)

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.

Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana

Stem cell reports　Vol. 10　No. 4　p. 1340-1354　2018/04/10　Research paper (scientific journal)

Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

Shunsuke Kuroki, Naoki Okashita, Shoko Baba, Ryo Maeda, Shingo Miyawaki, Masashi Yano, Miyoko Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Akihiro Itoh, Minoru Yoshida, Makoto Tachibana

PLoS Genetics　Vol. 13　No. 9　2017/09/01　Research paper (scientific journal)

Epigenetics of sex determination in mammals.

Makoto Tachibana

Reproductive medicine and biology　Vol. 15　No. 2　p. 59-67　2016/04　Research paper (scientific journal)

Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.

Shunsuke Kuroki, Mika Akiyoshi, Ko Ideguchi, Satsuki Kitano, Hitoshi Miyachi, Michiko Hirose, Nathan Mise, Kuniya Abe, Atsuo Ogura, Makoto Tachibana

Genesis (New York, N.Y. : 2000)　Vol. 53　No. 6　p. 387-93　2015/06　Research paper (scientific journal)

JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice.

Shunsuke Kuroki, Mika Akiyoshi, Mikiyo Tokura, Hitoshi Miyachi, Yuji Nakai, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana

Biology of reproduction　Vol. 89　No. 4　p. 93-93　2013/10　Research paper (scientific journal)

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.

Shunsuke Kuroki, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana

Science (New York, N.Y.)　Vol. 341　No. 6150　p. 1106-9　2013/09/06　Research paper (scientific journal)

Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells.

Katsuaki Deguchi, Go Nagamatsu, Hitoshi Miyachi, Yuzuru Kato, Sumiyo Morita, Hiroshi Kimura, Satsuki Kitano, Izuho Hatada, Yumiko Saga, Makoto Tachibana, Yoichi Shinkai

Biology of reproduction　Vol. 88　No. 2　p. 36-36　2013/02　Research paper (scientific journal)

H3K9 methyltransferase G9a and the related molecule GLP.

Yoichi Shinkai, Makoto Tachibana

Genes & development　Vol. 25　No. 8　p. 781-8　2011/04/15　Research paper (scientific journal)

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.

Toshiyuki Matsui, Danny Leung, Hiroki Miyashita, Irina A Maksakova, Hitoshi Miyachi, Hiroshi Kimura, Makoto Tachibana, Matthew C Lorincz, Yoichi Shinkai

Nature　Vol. 464　No. 7290　p. 927-31　2010/04/08　Research paper (scientific journal)

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

Takeshi Inagaki, Makoto Tachibana, Kenta Magoori, Hiromi Kudo, Toshiya Tanaka, Masashi Okamura, Makoto Naito, Tatsuhiko Kodama, Yoichi Shinkai, Juro Sakai

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 14　No. 8　p. 991-1001　2009/08　Research paper (scientific journal)

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.

Makoto Tachibana, Yasuko Matsumura, Mikiko Fukuda, Hiroshi Kimura, Yoichi Shinkai

The EMBO journal　Vol. 27　No. 20　p. 2681-90　2008/10/22　Research paper (scientific journal)

Functional dynamics of H3K9 methylation during meiotic prophase progression.

Makoto Tachibana, Masami Nozaki, Naoki Takeda, Yoichi Shinkai

The EMBO journal　Vol. 26　No. 14　p. 3346-59　2007/07/25　Research paper (scientific journal)

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

Jun Ueda, Makoto Tachibana, Tsuyoshi Ikura, Yoichi Shinkai

The Journal of biological chemistry　Vol. 281　No. 29　p. 20120-8　2006/07/21　Research paper (scientific journal)

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

Makoto Tachibana, Jun Ueda, Mikiko Fukuda, Naoki Takeda, Tsutomu Ohta, Hiroko Iwanari, Toshiko Sakihama, Tatsuhiko Kodama, Takao Hamakubo, Yoichi Shinkai

Genes & development　Vol. 19　No. 7　p. 815-26　2005/04/01　Research paper (scientific journal)

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.

Makoto Tachibana, Kenji Sugimoto, Masami Nozaki, Jun Ueda, Tsutomu Ohta, Misao Ohki, Mikiko Fukuda, Naoki Takeda, Hiroyuki Niida, Hiroyuki Kato, Yoichi Shinkai

Genes & development　Vol. 16　No. 14　p. 1779-91　2002/07/15　Research paper (scientific journal)

SET domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

M Tachibana, K Sugimoto, T Fukushima, Y Shinkai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 27　p. 25309-25317　2001/07　Research paper (scientific journal)

Cloning of mice to six generations

Teruhiko Wakayama, Yoichi Shinkai, Kellie L. K. Tamashiro, Hiroyuki Niida, D. Caroline Blanchard, Robert J. Blanchard, Atsuo Ogura, Kentaro Tanemura, Makoto Tachibana, Anthony C. F. Perry, Diana F. Colgan, Peter Mombaerts, Ryuzo Yanagimachi

Nature　Vol. 407　No. 6802　p. 318-319　2000/09/21　Research paper (scientific journal)

Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus

M Tachibana, MA Siddiqi, Y Ikegami, K Eshima, Y Shirota-Someya, S Tahara-Hanaoka, A Koito, M Iizuka, N Shinohara

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 27　p. 20288-20294　2000/07　Research paper (scientific journal)

Substrate specificity of dimethyl sulfoxide reductase as proved by micellar electrokinetic chromatography

Makoto Tachibana, Ken Sasaki, Akira Okubo, Sunao Yamazaki

BUNSEKI KAGAKU　Vol. 44　No. 10　p. 809-813　1995　Research paper (scientific journal)

Application of micellar electrokinetic chromatography for monitoring the kinetic resolution of sulfoxides by dimethyl sulfoxide reductase

Mitsuru Abo, Makoto Tachibana, Akira Okubo, Sunao Yamazaki

BUNSEKI KAGAKU　Vol. 44　No. 10　p. 835-838　1995　Research paper (scientific journal)

Application of Micellar Electrokinetic Chromatography as a Novel Assay Method for Dimethyl Sulfoxide Reductase

Makoto Tachibana, Hiroyuki Onoe, Akira Okubo, Sunao Yamazaki

Bioscience, Biotechnology, and Biochemistry　Vol. 59　No. 2　p. 282-284　1995　Research paper (scientific journal)

Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling.

Chenxu Yang, Makoto Arai, Eko Fuji Ariyanto, Ji Zhang, Debby Mirani Lubis, Ryo Ito, Shiyu Xie, Mio Nitta, Fuka Kawashima, Tomofumi Ishitsuka, Chaoran Yang, Tomohiro Suzuki, Tetsuro Komatsu, Hina Sagae, Hitomi Jin, Hiroki Takahashi, Eri Kobayashi, Yuchen Wei, Bohao Liu, Hyunmi Choi, Youichiro Wada, Toshiya Tanaka, Tsuyoshi Osawa, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Makoto Tachibana, Yoichi Shinkai, Takeshi Inagaki, Tomoyoshi Soga, Timothy F Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai

Cell reports　Vol. 44　No. 8　p. 116060-116060　2025/07/26　Research paper (scientific journal)

The histone H3K9 methyltransferase G9a regulates tendon formation during development.

Satoshi Wada, Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Noboru Demura, Hiroshi Tomonari, Hiroshi Kimura, Makoto Tachibana, Akira Nifuji

Scientific reports　Vol. 14　No. 1　p. 20771-20771　2024/09/05　Research paper (scientific journal)

The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function.

Koichiro Komatsu, Hisashi Ideno, Kazuhisa Nakashima, Nobuyuki Udagawa, Yasuhiro Kobayashi, Hiroshi Kimura, Makoto Tachibana, Teruhito Yamashita, Akira Nifuji

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 38　No. 13　2024/07/15　Research paper (scientific journal)

Corrigendum to "G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development" [Bone 137 (2020) 115332].

Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Ryoko Araki, Masumi Abe, Yoshinori Arai, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji

Bone　Vol. 180　p. 117000-117000　2024/03

Epigenetic modifier G9a is involved in regulation of mouse tongue development.

Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji

Journal of oral biosciences　Vol. 66　No. 1　p. 35-40　2024/03　Research paper (scientific journal)

The Evolutionary Aspects of the Mammalian Sex-Determining Gene SRY

Shingo Miyawaki, Makoto Tachibana

Spectrum of Sex　p. 69-84　2022/11/08　Part of collection (book)

Generation of ovarian follicles from mouse pluripotent stem cells.

Takashi Yoshino, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, Makoto Tachibana, Miki Inoue, Yuichi Shima, Ken-Ichirou Morohashi, Katsuhiko Hayashi

Science (New York, N.Y.)　Vol. 373　No. 6552　p. eabe0237-eabe0237　2021/07/16　Research paper (scientific journal)

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.

Yuki Horisawa-Takada, Chisato Kodera, Kazumasa Takemoto, Akihiko Sakashita, Kenichi Horisawa, Ryo Maeda, Ryuki Shimada, Shingo Usuki, Sayoko Fujimura, Naoki Tani, Kumi Matsuura, Tomohiko Akiyama, Atsushi Suzuki, Hitoshi Niwa, Makoto Tachibana, Takashi Ohba, Hidetaka Katabuchi, Satoshi H Namekawa, Kimi Araki, Kei-Ichiro Ishiguro

Nature communications　Vol. 12　No. 1　p. 3184-3184　2021/06/01　Research paper (scientific journal)

Dynamic erectile responses of a novel penile organ model utilizing TPEM†.

Daiki Hashimoto, Tsuyoshi Hirashima, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, Kentaro Suzuki, Nobuhiko Yamamoto, Shin Morioka, Takehiko Sasaki, Gen Yamada

Biology of reproduction　Vol. 104　No. 4　p. 875-886　2021/04/01　Research paper (scientific journal)

Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis.

Takuma Nakatsuka, Keisuke Tateishi, Hiroyuki Kato, Hiroaki Fujiwara, Keisuke Yamamoto, Yotaro Kudo, Hayato Nakagawa, Yasuo Tanaka, Hideaki Ijichi, Tsuneo Ikenoue, Takeaki Ishizawa, Kiyoshi Hasegawa, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike

Cell death & disease　Vol. 12　No. 1　p. 99-99　2021/01/19　Research paper (scientific journal)

Publisher's Note: "Capacitive detection of magnetostriction, dielectric constant, and magneto-caloric effects in pulsed magnetic fields" [Rev. Sci. Instrum. 91, 105103 (2020)].

Atsushi Miyake, Hiroyuki Mitamura, Shiro Kawachi, Kenta Kimura, Tsuyoshi Kimura, Takumi Kihara, Makoto Tachibana, Masashi Tokunaga

The Review of scientific instruments　Vol. 91　No. 11　p. 119901-119901　2020/11/01

Capacitive detection of magnetostriction, dielectric constant, and magneto-caloric effects in pulsed magnetic fields.

Atsushi Miyake, Hiroyuki Mitamura, Shiro Kawachi, Kenta Kimura, Tsuyoshi Kimura, Takumi Kihara, Makoto Tachibana, Masashi Tokunaga

The Review of scientific instruments　Vol. 91　No. 10　p. 105103-105103　2020/10/01　Research paper (scientific journal)

G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development.

Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Ryoko Araki, Masumi Abe, Yoshinori Arai, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji

Bone　Vol. 137　p. 115332-115332　2020/08　Research paper (scientific journal)

Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis.

Masataka Someda, Shunsuke Kuroki, Hitoshi Miyachi, Makoto Tachibana, Shin Yonehara

Cell death and differentiation　Vol. 27　No. 5　p. 1539-1553　2020/05　Research paper (scientific journal)

Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis.

Hiroyuki Kato, Keisuke Tateishi, Hiroaki Fujiwara, Hideaki Ijichi, Keisuke Yamamoto, Takuma Nakatsuka, Miwako Kakiuchi, Makoto Sano, Yotaro Kudo, Yoku Hayakawa, Hayato Nakagawa, Yasuo Tanaka, Motoyuki Otsuka, Yoshihiro Hirata, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike

Cancer genomics & proteomics　Vol. 17　No. 6　p. 695-705　2020　Research paper (scientific journal)

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.

Wan Kin Au Yeung, Julie Brind'Amour, Yu Hatano, Kazuo Yamagata, Robert Feil, Matthew C Lorincz, Makoto Tachibana, Yoichi Shinkai, Hiroyuki Sasaki

Cell reports　Vol. 27　No. 1　p. 282-293　2019/04/02　Research paper (scientific journal)

G9a-dependent histone methylation can be induced in G1 phase of cell cycle.

Mikiko Fukuda, Asako Sakaue-Sawano, Chikako Shimura, Makoto Tachibana, Atsushi Miyawaki, Yoichi Shinkai

Scientific reports　Vol. 9　No. 1　p. 956-956　2019/01/30　Research paper (scientific journal)

Epigenetic regulation of mammalian sex determination.

Shunsuke Kuroki, Makoto Tachibana

Molecular and cellular endocrinology　Vol. 468　p. 31-38　2018/06/15　Research paper (scientific journal)

FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche.

Kaito Masaki, Mizuki Sakai, Shunsuke Kuroki, Jun-Ichiro Jo, Kazuo Hoshina, Yuki Fujimori, Kenji Oka, Toshiyasu Amano, Takahiro Yamanaka, Makoto Tachibana, Yasuhiko Tabata, Tanri Shiozawa, Osamu Ishizuka, Shinichi Hochi, Seiji Takashima

Stem cell reports　Vol. 10　No. 6　p. 1782-1792　2018/06/05　Research paper (scientific journal)

DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells.

Daiki Tatsumi, Yohei Hayashi, Mai Endo, Hisato Kobayashi, Takumi Yoshioka, Kohei Kiso, Shinichiro Kanno, Yuji Nakai, Ikuma Maeda, Kentaro Mochizuki, Makoto Tachibana, Haruhiko Koseki, Akihiko Okuda, Akira Yasui, Tomohiro Kono, Yasuhisa Matsui

PloS one　Vol. 13　No. 11　2018　Research paper (scientific journal)

H3K9MTase G9a regulates tooth development in mice.

Hisashi Ideno, Taichi Kamiunten, Akemi Shimada, Tatsuo Terashima, Kazuhisa Nakashima, Yasuhiro Tomooka, Yoshiki Nakamura, Hiroshi Kimura, Makoto Tachibana, Akira Nifuji

JOURNAL OF BONE AND MINERAL RESEARCH　Vol. 32　p. S334-S334　2017/12

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation

T. Nakatsuka, K. Tateishi, Y. Kudo, K. Yamamoto, H. Nakagawa, H. Fujiwara, R. Takahashi, K. Miyabayashi, Y. Asaoka, Y. Tanaka, H. Ijichi, Y. Hirata, M. Otsuka, M. Kato, J. Sakai, M. Tachibana, H. Aburatani, Y. Shinkai, K. Koike

ONCOGENE　Vol. 36　No. 45　p. 6262-6271　2017/11　Research paper (scientific journal)

Essential roles of G9a in cell proliferation and differentiation during tooth development.

Taichi Kamiunten, Hisashi Ideno, Akemi Shimada, Yoshinori Arai, Tatsuo Terashima, Yasuhiro Tomooka, Yoshiki Nakamura, Kazuhisa Nakashima, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji

Experimental cell research　Vol. 357　No. 2　p. 202-210　2017/08/15　Research paper (scientific journal)

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.

Naoki Okashita, Yoshiaki Suwa, Osamu Nishimura, Nao Sakashita, Mitsutaka Kadota, Go Nagamatsu, Masanori Kawaguchi, Hiroki Kashida, Ayaka Nakajima, Makoto Tachibana, Yoshiyuki Seki

Stem cell reports　Vol. 7　No. 6　p. 1072-1086　2016/12/13　Research paper (scientific journal)

Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.

Daisuke Muramatsu, Hiroshi Kimura, Kaoru Kotoshiba, Makoto Tachibana, Yoichi Shinkai

Cell structure and function　Vol. 41　No. 2　p. 145-152　2016/12/03　Research paper (scientific journal)

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia.

Damayanti Chakraborty, Wei Cui, Gracy X Rosario, Regan L Scott, Pramod Dhakal, Stephen J Renaud, Makoto Tachibana, M A Karim Rumi, Clifford W Mason, Adam J Krieg, Michael J Soares

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 46　p. E7212-E7221-E7221　2016/11/15　Research paper (scientific journal)

ヒストンメチル化酵素G9aは腱組織の正常な発生に必要である

和田 悟史, 出野 尚, 島田 明美, 上運天 太一, 中村 芳樹, 中島 和久, 木村 宏, 眞貝 洋一, 立花 誠, 二藤 彰

Journal of Oral Biosciences Supplement　Vol. 2016　p. 589-589　2016/09

H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro.

Satoshi Wada, Hisashi Ideno, Akemi Shimada, Taichi Kamiunten, Yoshiki Nakamura, Kazuhisa Nakashima, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji

Histochemistry and cell biology　Vol. 144　No. 1　p. 13-20　2015/07　Research paper (scientific journal)

Epigenetic regulation of mammalian sex determination.

Makoto Tachibana

The journal of medical investigation : JMI　Vol. 62　No. 1-2　p. 19-23　2015　Research paper (scientific journal)

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines (vol 65, pg 263, 2012)

Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-Ya, Yasuhiro Igarashi, Akihiro Ito, Minoru Yoshida

JOURNAL OF ANTIBIOTICS　Vol. 67　No. 10　p. 737-738　2014/10

The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

Jun Ueda, Jolene Caifeng Ho, Kian Leong Lee, Shojiro Kitajima, Henry Yang, Wendi Sun, Noriko Fukuhara, Norazean Zaiden, Shing Leng Chan, Makoto Tachibana, Yoichi Shinkai, Hiroyuki Kato, Lorenz Poellinger

Molecular and cellular biology　Vol. 34　No. 19　p. 3702-20　2014/10/01　Research paper (scientific journal)

Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.

Nick Warr, Pam Siggers, Gwenn-Aël Carré, Debora Bogani, Rachel Brixey, Mika Akiyoshi, Makoto Tachibana, Lydia Teboul, Sara Wells, Jeremy Sanderson, Andy Greenfield

Human molecular genetics　Vol. 23　No. 11　p. 3035-44　2014/06/01　Research paper (scientific journal)

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis

Masayo Inagawa, Kuniko Nakajima, Tomoyuki Makino, Satoko Ogawa, Mizuyo Kojima, Satomi Ito, Aiko Ikenishi, Toshinori Hayashi, Robert J. Schwartz, Kazuomi Nakamura, Tetsuya Obayashi, Makoto Tachibana, Yoichi Shinkai, Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Takashi Takeuchi

MECHANISMS OF DEVELOPMENT　Vol. 130　No. 11-12　p. 519-531　2013/11　Research paper (scientific journal)

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.

Yuka Fujimoto, Satomi S Tanaka, Yasuka L Yamaguchi, Hiroki Kobayashi, Shunsuke Kuroki, Makoto Tachibana, Mai Shinomura, Yoshiakira Kanai, Ken-Ichirou Morohashi, Kiyoshi Kawakami, Ryuichi Nishinakamura

Developmental cell　Vol. 26　No. 4　p. 416-30　2013/08/26　Research paper (scientific journal)

A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.

Rika Ohno, Megumi Nakayama, Chie Naruse, Naoki Okashita, Osamu Takano, Makoto Tachibana, Masahide Asano, Mitinori Saitou, Yoshiyuki Seki

Development (Cambridge, England)　Vol. 140　No. 14　p. 2892-903　2013/07　Research paper (scientific journal)

Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome.

Monique C M Balemans, Nael Nadif Kasri, Maksym V Kopanitsa, Nurudeen O Afinowi, Ger Ramakers, Theo A Peters, Andy J Beynon, Sanne M Janssen, Rik C J van Summeren, Jorine M Eeftens, Nathalie Eikelenboom, Marco Benevento, Makoto Tachibana, Yoichi Shinkai, Tjitske Kleefstra, Hans van Bokhoven, Catharina E E M Van der Zee

Human molecular genetics　Vol. 22　No. 5　p. 852-66　2013/03/01　Research paper (scientific journal)

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.

Toshinobu Nakamura, Yu-Jung Liu, Hiroyuki Nakashima, Hiroki Umehara, Kimiko Inoue, Shogo Matoba, Makoto Tachibana, Atsuo Ogura, Yoichi Shinkai, Toru Nakano

Nature　Vol. 486　No. 7403　p. 415-9　2012/06/03　Research paper (scientific journal)

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-ya, Yasuhiro Igarashi, Akihiro Ito, Minoru Yoshida

The Journal of antibiotics　Vol. 65　No. 5　p. 263-5　2012/05　Research paper (scientific journal)

始原生殖細胞におけるDNAの脱メチル化と2価ヒストン修飾を介した選択的なエピジェネティック遺伝子調節(Selective epigenetic gene regulation via DNA demethylation and bivalent histone modification in primordial germ cells)

Mochizuki Kentaro, Tachibana Makoto, Saitou Mitinori, Tokitake Yuko, Matsui Yasuhisa

日本発生生物学会・日本細胞生物学会合同大会要旨集　Vol. 45回・64回　p. 265-265　2012/04

DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Takahashi, A, Imai, Y, Yamakoshi, K, Kuninaka, S, Ohtani, N, Yoshimoto, S, Hori, S, Tachibana, M, Anderton, E, Takeuchi, T, Shinkai, Y, Peters, G, Saya, H, Hara, E

Mol Cell　Vol. 45　No. 1　p. 123-31　2012/01/13

DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.

Akiko Takahashi, Yoshinori Imai, Kimi Yamakoshi, Shinji Kuninaka, Naoko Ohtani, Shin Yoshimoto, Satoshi Hori, Makoto Tachibana, Emma Anderton, Takashi Takeuchi, Yoichi Shinkai, Gordon Peters, Hideyuki Saya, Eiji Hara

Molecular cell　Vol. 45　No. 1　p. 123-31　2012/01/13　Research paper (scientific journal)

Implication of DNA demethylation and bivalent histone modification for selective gene regulation in mouse primordial germ cells.

Kentaro Mochizuki, Makoto Tachibana, Mitinori Saitou, Yuko Tokitake, Yasuhisa Matsui

PloS one　Vol. 7　No. 9　2012　Research paper (scientific journal)

HP1γ links histone methylation marks to meiotic synapsis in mice.

Yuki Takada, Chie Naruse, Yael Costa, Takayuki Shirakawa, Makoto Tachibana, Jafar Sharif, Fuyuko Kezuka-Shiotani, Dai Kakiuchi, Hiroshi Masumoto, Yo-ichi Shinkai, Kazuyuki Ohbo, Antoine H F M Peters, James M A Turner, Masahide Asano, Haruhiko Koseki

Development (Cambridge, England)　Vol. 138　No. 19　p. 4207-17　2011/10　Research paper (scientific journal)

初期胚におけるヒストン修飾によるDNAメチル化とヒドロキシメチル化の相反性調節(Reciprocal regulation of DNA methylation and hydroxymethylation in early embryos by histone modification)

中村 肇伸, Wossidlo Mark, 立花 誠, 眞貝 洋一, Walter Joern, 仲野 徹

日本生化学会大会プログラム・講演要旨集　Vol. 84回　p. 2S12a-6　2011/09

Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling.

Yoko Hayashi-Takanaka, Kazuo Yamagata, Teruhiko Wakayama, Timothy J Stasevich, Takashi Kainuma, Toshiki Tsurimoto, Makoto Tachibana, Yoichi Shinkai, Hitoshi Kurumizaka, Naohito Nozaki, Hiroshi Kimura

Nucleic acids research　Vol. 39　No. 15　p. 6475-88　2011/08　Research paper (scientific journal)

Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.

Danny C Leung, Kevin B Dong, Irina A Maksakova, Preeti Goyal, Ruth Appanah, Sandra Lee, Makoto Tachibana, Yoichi Shinkai, Bernhard Lehnertz, Dixie L Mager, Fabio Rossi, Matthew C Lorincz

Proceedings of the National Academy of Sciences of the United States of America　Vol. 108　No. 14　p. 5718-23　2011/04/05　Research paper (scientific journal)

Histone H1 null vertebrate cells exhibit altered nucleosome architecture.

Hideharu Hashimoto, Yasunari Takami, Eiichiro Sonoda, Tomohito Iwasaki, Hidetomo Iwano, Makoto Tachibana, Shunichi Takeda, Tatsuo Nakayama, Hiroshi Kimura, Yoichi Shinkai

Nucleic acids research　Vol. 38　No. 11　p. 3533-45　2010/06　Research paper (scientific journal)

Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice.

Monique C M Balemans, Manon M H Huibers, Nathalie W D Eikelenboom, Arthur J Kuipers, Rik C J van Summeren, Michael M C A Pijpers, Makoto Tachibana, Yoichi Shinkai, Hans van Bokhoven, Catharina E E M Van der Zee

Behavioural brain research　Vol. 208　No. 1　p. 47-55　2010/03/17　Research paper (scientific journal)

Obesity and metabolic syndrome in histone demethylase JHDM2a deficient mice

Juro Sakai, Takeshi Inagaki, Makoto Tachibana, Toshiya Tanaka, Kenta Magoori, Tatsuhiko Kodama, Yoichi Shinkai

ENDOCRINE JOURNAL　Vol. 57　p. S261-S262　2010/03

G9a selectively represses a class of late-replicating genes at the nuclear periphery.

Tomoki Yokochi, Kristina Poduch, Tyrone Ryba, Junjie Lu, Ichiro Hiratani, Makoto Tachibana, Yoichi Shinkai, David M Gilbert

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 46　p. 19363-8　2009/11/17　Research paper (scientific journal)

Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.

Petra A Link, Omkaram Gangisetty, Smitha R James, Anna Woloszynska-Read, Makoto Tachibana, Yoichi Shinkai, Adam R Karpf

Molecular cancer research : MCR　Vol. 7　No. 6　p. 851-62　2009/06　Research paper (scientific journal)

G9a is required for DNA methylation of retroviral elements and silencing of introduced proviruses in embryonic stem cells

K. B. Dong, I. A. Maksakova, R. Appanah, S. Lee, H. W. Yang, D. L. Mager, M. Tachibana, Y. Shinkai, M. C. Lorincz

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE　Vol. 87　No. 1　p. 371-371　2009/02

A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.

Haruki Shirato, Satoko Ogawa, Kuniko Nakajima, Masayo Inagawa, Mizuyo Kojima, Makoto Tachibana, Yoichi Shinkai, Takashi Takeuchi

The Journal of biological chemistry　Vol. 284　No. 2　p. 733-9　2009/01/09　Research paper (scientific journal)

DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.

Kevin B Dong, Irina A Maksakova, Fabio Mohn, Danny Leung, Ruth Appanah, Sandra Lee, Hao W Yang, Lucia L Lam, Dixie L Mager, Dirk Schübeler, Makoto Tachibana, Yoichi Shinkai, Matthew C Lorincz

The EMBO journal　Vol. 27　No. 20　p. 2691-701　2008/10/22　Research paper (scientific journal)

Distinct roles of TRF1 in the regulation of telomere structure and lengthening.

Keiji Okamoto, Tomohiko Iwano, Makoto Tachibana, Yoichi Shinkai

The Journal of biological chemistry　Vol. 283　No. 35　p. 23981-8　2008/08/29　Research paper (scientific journal)

Characterization of Drosophila G9a in vivo and identification of genetic interactants.

Yasuko Kato, Masaki Kato, Makoto Tachibana, Yoichi Shinkai, Masamitsu Yamaguchi

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 13　No. 7　p. 703-22　2008/07　Research paper (scientific journal)

Functional analysis of histone methyltransferase g9a in B and T lymphocytes.

Lance R Thomas, Hiroki Miyashita, Robin Milley Cobb, Steven Pierce, Makoto Tachibana, Elias Hobeika, Michael Reth, Yoichi Shinkai, Eugene M Oltz

Journal of immunology (Baltimore, Md. : 1950)　Vol. 181　No. 1　p. 485-93　2008/07/01　Research paper (scientific journal)

[Regulation of germ cell differentiation by histone methylation].

Makoto Tachibana, Yoichi Shinkai

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 52　No. 16 Suppl　p. 2157-62　2007/12　Research paper (scientific journal)

Histone H1 variant, H1R is involved in DNA damage response.

Hideharu Hashimoto, Eiichiro Sonoda, Yasunari Takami, Hiroshi Kimura, Tatsuo Nakayama, Makoto Tachibana, Shunichi Takeda, Yoichi Shinkai

DNA repair　Vol. 6　No. 11　p. 1584-95　2007/11　Research paper (scientific journal)

Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.

Yoshiyuki Seki, Masashi Yamaji, Yukihiro Yabuta, Mitsue Sano, Mayo Shigeta, Yasuhisa Matsui, Yumiko Saga, Makoto Tachibana, Yoichi Shinkai, Mitinori Saitou

Development (Cambridge, England)　Vol. 134　No. 14　p. 2627-38　2007/07　Research paper (scientific journal)

Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.

Miki Nishida, Masaki Kato, Yasuko Kato, Nobuhiro Sasai, Jun Ueda, Makoto Tachibana, Yoichi Shinkai, Masamitsu Yamaguchi

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 12　No. 7　p. 877-88　2007/07　Research paper (scientific journal)

Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells.

Kohta Ikegami, Misa Iwatani, Masako Suzuki, Makoto Tachibana, Yoichi Shinkai, Satoshi Tanaka, John M Greally, Shintaro Yagi, Naka Hattori, Kunio Shiota

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 12　No. 1　p. 1-11　2007/01　Research paper (scientific journal)

Rad54 is dispensable for the ALT pathway.

Koichi Akiyama, Kosuke Yusa, Hideharu Hashimoto, Anuradha Poonepalli, Manoor Prakash Hande, Naoki Kakazu, Junji Takeda, Makoto Tachibana, Yoichi Shinkai

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 11　No. 11　p. 1305-15　2006/11　Research paper (scientific journal)

Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position.

Tomohisa Moriguchi, Hirokazu Sekiguchi, Makoto Tachibana, Kazuo Shinozuka

Nucleosides, nucleotides & nucleic acids　Vol. 25　No. 4-6　p. 601-12　2006　Research paper (scientific journal)

[Mammalian histone methyltransferases].

Makoto Tachibana

Seikagaku. The Journal of Japanese Biochemical Society　Vol. 78　No. 1　p. 50-3　2006/01　Research paper (scientific journal)

In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases.

Robert E Collins, Makoto Tachibana, Hisashi Tamaru, Kristina M Smith, Da Jia, Xing Zhang, Eric U Selker, Yoichi Shinkai, Xiaodong Cheng

The Journal of biological chemistry　Vol. 280　No. 7　p. 5563-70　2005/02/18　Research paper (scientific journal)

X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a.

Tatsuya Ohhata, Makoto Tachibana, Masako Tada, Takashi Tada, Hiroyuki Sasaki, Yoichi Shinkai, Takashi Sado

Genesis (New York, N.Y. : 2000)　Vol. 40　No. 3　p. 151-6　2004/11　Research paper (scientific journal)

Targeted inhibition of V(D)J recombination by a histone methyltransferase.

Oleg Osipovich, Robin Milley, Amber Meade, Makoto Tachibana, Yoichi Shinkai, Michael S Krangel, Eugene M Oltz

Nature immunology　Vol. 5　No. 3　p. 309-16　2004/03　Research paper (scientific journal)

Importance of TRF1 for functional telomere structure.

Tomohiko Iwano, Makoto Tachibana, Michael Reth, Yoichi Shinkai

The Journal of biological chemistry　Vol. 279　No. 2　p. 1442-8　2004/01/09　Research paper (scientific journal)

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

Antoine H F M Peters, Stefan Kubicek, Karl Mechtler, Roderick J O'Sullivan, Alwin A H A Derijck, Laura Perez-Burgos, Alexander Kohlmaier, Susanne Opravil, Makoto Tachibana, Yoichi Shinkai, Joost H A Martens, Thomas Jenuwein

Molecular cell　Vol. 12　No. 6　p. 1577-89　2003/12　Research paper (scientific journal)

Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.

Naoyuki Fujita, Sugiko Watanabe, Takaya Ichimura, Shu Tsuruzoe, Yoichi Shinkai, Makoto Tachibana, Tsutomu Chiba, Mitsuyoshi Nakao

The Journal of biological chemistry　Vol. 278　No. 26　p. 24132-8　2003/06/27　Research paper (scientific journal)

Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center.

Zhenghan Xin, Makoto Tachibana, Michele Guggiari, Edith Heard, Yoichi Shinkai, Joseph Wagstaff

The Journal of biological chemistry　Vol. 278　No. 17　p. 14996-5000　2003/04/25　Research paper (scientific journal)

Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalpha.

Kenji Sugimoto, Takeshi Urano, Hitomi Zushi, Kimiko Inoue, Hiroaki Tasaka, Makoto Tachibana, Masaya Dotsu

Cell structure and function　Vol. 27　No. 6　p. 457-67　2002/12　Research paper (scientific journal)

Molecular dynamics in living mitotic cells of histone H3, centrosomal kinase Aurora-A and nuclear membrane protein importin alpha differentially expressed as fusions to cyan, green and red fluorescent proteins

K Sugimoto, T Urano, M Tachibana, M Dotsu

MOLECULAR BIOLOGY OF THE CELL　Vol. 13　p. 50A-51A　2002/11

Role of histone methyltransferase, G9a in H3 Lys9 methylation and CpG methylation of the Prader-Willi imprinting center.

Z Xin, M Tachibana, Y Shinkai, J Wagstaff

AMERICAN JOURNAL OF HUMAN GENETICS　Vol. 71　No. 4　p. 493-493　2002/10

Production of cloned mice from embryonic stem cells arrested at metaphase

Y. Ono, N. Shimozawa, K. Muguruma, S. Kimoto, K. Hioki, M. Tachibana, Y. Shinkai, M. Ito, T. Kono

Reproduction　Vol. 122　No. 5　p. 731-736　2001　Research paper (scientific journal)

Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplified telomeric DNA

H Niida, Y Shinkai, MP Hande, T Matsumoto, S Takehara, M Tachibana, M Oshimura, PM Lansdorp, Y Furuichi

MOLECULAR AND CELLULAR BIOLOGY　Vol. 20　No. 11　p. 4115-4127　2000/06　Research paper (scientific journal)

Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins

S Yamasaki, M Tachibana, N Shinohara, M Iwashima

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 23　p. 14787-14791　1997/06　Research paper (scientific journal)

Co-receptor-independent signal transduction in a mismatched CD8(+) major histocompatibility complex class II-specific allogeneic cytotoxic T lymphocyte

K Eshima, M Tachibana, H Suzuki, S Yamazaki, N Shinohara

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 27　No. 1　p. 55-61　1997/01　Research paper (scientific journal)

CD4T cells, Positive selection, and Surveillance of Autoantibody Production

The immunologist　Vol. 514　1997

Comparative analysis of the gp120-binding area of murine and human CD4 molecules

MA Siddiqi, M Tachibana, S Ohta, Y Ikegami, S TaharaHanaoka, YY Huang, N Shinohara

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY　Vol. 14　No. 1　p. 7-12　1997/01　Research paper (scientific journal)

Enantioselective deoxygenation of alkyl aryl sulfoxides by DMSO reductase from Rhodobacter sphaeroides f.s. denitrificans

Mitsuru Abo, Makoto Tachibana, Akira Okubo, Sunao Yamazaki

Bioorganic and Medicinal Chemistry　Vol. 3　No. 2　p. 109-112　1995　Research paper (scientific journal)

Enantioselective Reduction of the Sulfoxide to Sulfide in Methyl Phenyl Sulfoxide by Dimethyl Sulfoxide Reductase from Rhodobacter sphaeroides f. s. denitrificans

Mitsuru Abo, Makoto Tachibana, Akira Okubo, Sunao Yamazaki

Bioscience, Biotechnology, and Biochemistry　Vol. 58　No. 3　p. 596-597　1994　Research paper (scientific journal)