Carnitine Administration and <sup>123</sup>I-BMIPP Washout Rate in Hemodialysis Patients with Triglyceride Deposit Cardiomyovasculopathy

Ken-ichi Hirano, Keita Kodama, Hideyuki Miyauchi, Yasuyuki Nagasawa, Yusuke Nakano, Masaki Matsunaga, Tetsuya Amano, Kenichi Nakajima

Annals of Nuclear Cardiology　2023　Research paper (scientific journal)

Tricaprin can prevent the development of AAA by attenuating aortic degeneration

Hirona Kugo, Yuki Sugiura, Rena Fujishima, Shintou Jo, Hirotaka Mishima, Erina Sugamoto, Hiroki Tanaka, Satoshi Yamaguchi, Yoshihiko Ikeda, Ken-Ichi Hirano, Tatsuya Moriyama, Nobuhiro Zaima

Biomed Pharmacother　Vol. in press　p. 114299-114299　2023　Research paper (scientific journal)

A novel fluorescently-labeled long-chain fatty acid analog for the study of fatty acid metabolism in cultured cells

bioRxiv　2022/12　Research paper (scientific journal)

Methods of calculating 123I-β-methyl-P-iodophenyl-pentadecanoic acid washout rates in triglyceride deposit cardiomyovasculopathy

Chen Z, Nakajima K, Hirano K, Kamiya T, Yoshida S, Saito S, Kinuya S

Ann Nucl Med　Vol. 36　No. 11　p. 986-997　2022/11　Research paper (scientific journal)

Modified Algorithm Using Total Count for Calculating Myocardial Washout Rate in Single-Photon Emission Computerized Tomography

Miyauchi H, Ono R, Iimori T, Sawada K, Hoshi K, Hirano K, Kobayashi Y

Ann Nucl Cardiol　Vol. in press　2022/09　Research paper (scientific journal)

A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice

Swamy MMM, Zubir MZM, Mutmainah, Tsuboi S, Murai Y, Monde K, Hirano K, Jin T

Analyst　Vol. 147　No. 19　p. 4206-4212　2022/09　Research paper (scientific journal)

123I-BMIPP scintigraphy shows that CNT-01(tricaprin) improves myocardial lipolysis in patients with idiopathic triglyceride deposit cardiomyovasculopathy: First randomized controlled, exploratory trial for TGCV

Miyauchi H, Hirano K, Nakano Y, Shimada K, Nishikawa M, Yamamoto H, Nakamura A, Miyake A, Aoshima C, Fujimoto S, Nakatani D, Yamada T, Amano T, Nakajima K

Ann Nucl Cardiol　Vol. 8　No. 1　p. 67-75　2022/08　Research paper (scientific journal)

Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure

Aoshima C, Fujimoto S, Kudo A, Kawaguchi Y, Takamura K, Matsue Y, Kato T, Kawamura Y, Kimura S, Kamo Y, Nozaki Y, Takahashi D, Tomizawa N, Hiki M, Kasai T, Nojiri S, Miyauchi H, Hirano K, Shimada K, Murakami K, Minamino T

Eur J Nuc Med Mol Imaging　Vol. 49　No. 9　p. 3129-3139　2022/03　Research paper (scientific journal)

Genetic Deficiency of Adipose Triglyceride Lipase Is Associated With a Novel Type of Podocytopathy

Yasuyuki Nagasawa, Takahiro Okumura, Yasuhiro Hara, Toru Kondo, Midori Hasegawa, Yoshihiko Ikeda, Toyoaki Murohara

Kidney International Reports　Vol. 6　No. 10　p. 2722-2725　2021/10　Research paper (scientific journal)

Triglyceride Deposit Cardiomyovasculopathy with Massive Myocardial Triglyceride which was Proven Using Proton-magnetic Resonance Spectroscopy

Eiryu Sai, Kazunori Shimada, Tatsuro Aikawa, Chihiro Aoshima, Kazuhisa Takamura, Makoto Hiki, Takayuki Yokoyama, Tetsuro Miyazaki, Shinichiro Fujmoto, Hakuoh Konishi, Ken-ichi Hirano, Hiroyuki Daida, Tohru Minamino

Internal Medicine　Vol. 60　No. 8　p. 1217-1220　2021/04　Research paper (scientific journal)

Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice

Hirotsugu Noguchi, Sohsuke Yamada, Ken-Ichi Hirano, Satoshi Yamaguchi, Akira Suzuki, Xin Guo, Nobuhiro Zaima, Ming Li, Kunihisa Kobayashi, Yoshihiko Ikeda, Toshiyuki Nakayama, Yasuyuki Sasaguri

Histol Histopathol　Vol. 36　No. 1　p. 91-100　2021/01　Research paper (scientific journal)

Prevalence and clinical outcomes of triglyceride deposit cardiomyovasculopathy among haemodialysis patients

Onishi T, Nakano Y, Hirano K, Nagasawa Y, Niwa T, Tajima A, Ishii H, Takahashi H, Sakurai S, Ando H, Takashima H, Amano T

Heart　Vol. 107　No. 2　p. 127-134　2021/01　Research paper (scientific journal)

Effect of Tricaprin on Cardiac Proteome in a Mouse Model for Triglyceride Deposit Cardiomyovasculopathy

Yasuhiro Hara, Bo Zhang, Akira Suzuki, Satoshi Yamaguchi, Jun Adachi, Takeshi Tomonaga, Shin’ichiro Yasunaga, Keijiro Saku, Toshiaki Aoyama

Journal of Oleo Science　Vol. 69　No. 12　p. 1569-1577　2020/12　Research paper (scientific journal)

Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device

Hideo Oishi, Toru Kondo, Kazuro Fujimoto, Masato Mutsuga, Ryota Morimoto, Ken-ichi Hirano, Akinori Sawamura, Shingo Kazama, Yuki Kimura, Naoki Shibata, Hiroo Kato, Yoshihito Arao, Tasuku Kuwayama, Shogo Yamaguchi, Hiroaki Hiraiwa, Takahiro Okumura, Akihiko Usui, Toyoaki Murohara

Journal of Artificial Organs　Vol. 23　No. 4　p. 378-382　2020/12　Research paper (scientific journal)

Association of Triglyceride Deposit Cardiomyovasculopathy With Drug-Eluting Stent Restenosis Among Patients With Diabetes

Yusuke Nakano, Mayu Suzuki, Hirohiko Ando, Hiroaki Takashima, Hiroshi Takahashi, Tetsuya Amano

JAMA Network Open　Vol. 3　No. 8　2020/08/07　Research paper (scientific journal)

The Diagnostic Criteria 2020 for Triglyceride Deposit Cardiomyovasculopathy.

Kobayashi K, Sakata Y, Miyauchi H, Ikeda Y, Nagasawa Y, Shimada K, Nakajima K, Kozawa J, Hao H, Amano T, Yoshida H, Inaba T, Hashimoto C, Hirano K

Annals of Nuclear Cardiology　Vol. 6　No. 1　p. 99-104　2020/08　Research paper (scientific journal)

Correlation Perspectives for the Diagnosis of Idiopathic Triglyceride Deposit Cardiomyovasculopathy

Hideyuki Miyauchi, Takashi Iimori, Keisuke Hoshi, Masayuki Ohyama, Ken-ichi Hirano, Yoshio Kobayashi

Annals of Nuclear Cardiology　Vol. 6　No. 1　p. 33-38　2020/08　Research paper (scientific journal)

Levitating Cells to Sort the Fit and the Fat

Nazan Puluca, Naside Gözde Durmus, Soah Lee, Nadjet Belbachir, Francisco X. Galdos, Mehmet Giray Ogut, Rakhi Gupta, Markus Krane, Rüdiger Lange, Joseph C. Wu, Sean M. Wu, Zhonglin Lyu

Advanced Biosystems　Vol. 4　No. 6　p. 1900300-1900300　2020/06　Research paper (scientific journal)

A historical case of primary triglyceride deposit cardiomyovasculopathy

Michio Tanaka, Yoshihiko Ikeda, Ming Li, Nobuhiro Zaima, Yutaka Kawahara, Koji Watanabe, Tohru Inaba, Kunihisa Kobayashi, Hirotsugu Noguchi, Sohsuke Yamada, Hiroyuki Hao, Ken-ichi Hirano

Pathology International　Vol. 70　No. 1　p. 58-61　2020/01　Research paper (scientific journal)

Development of a simultaneous quantitation for short-, medium-, long-, and very long-chain fatty acids in human plasma by 2-nitrophenylhydrazine-derivatization and liquid chromatography-tandem mass spectrometry.

Zhen Chen, Zijun Gao, Yue Wu, Rojeet Shrestha, Hiromitsu Imai, Naoto Uemura, Ken-Ichi Hirano, Hitoshi Chiba, Shu-Ping Hui

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences　Vol. 1126-1127　p. 121771-121771　2019/09/15　Research paper (scientific journal)

Increased Washout of 123IBMIPP in Triglyceride Deposit Cardiomyovasculopathy (TGCV) with Severe Coronary Stenosis -A Pitfall of Diagnosis for TGCV-

Hirano K, Higashi M, Miyauchi H, Takagi A, Ikeda Y, Nakano Y, Amano T

Annals of Nuclear Cardiology　Vol. 5　No. 1　p. 47-49　2019/08　Research paper (scientific journal)

Development of a simultaneous quantitation for short-, medium-, long-, and very long-chain fatty acids in human plasma by 2-nitrophenylhydrazine-derivatization and liquid chromatography–tandem mass spectrometry

Zhen Chen, Zijun Gao, Yue Wu, Rojeet Shrestha, Hiromitsu Imai, Naoto Uemura, Ken-ichi Hirano, Hitoshi Chiba, Shu-Ping Hui

Journal of Chromatography B　Vol. 1126-1127　2019/08　Research paper (scientific journal)

Detection of Jordans’ anomaly using compact-type automated hematology analyzer

Tohru Inaba, Keita Okumura, Naohisa Fujita, Akira Suzuki

International Journal of Hematology　Vol. 110　No. 2　p. 129-130　2019/08　Research paper (scientific journal)

Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder.

Ming Li, Ken-Ichi Hirano, Yoshihiko Ikeda, Masahiro Higashi, Chikako Hashimoto, Bo Zhang, Junji Kozawa, Koichiro Sugimura, Hideyuki Miyauchi, Akira Suzuki, Yasuhiro Hara, Atsuko Takagi, Yasuyuki Ikeda, Kazuhiro Kobayashi, Yoshiaki Futsukaichi, Nobuhiro Zaima, Satoshi Yamaguchi, Rojeet Shrestha, Hiroshi Nakamura, Katsuhiro Kawaguchi, Eiryu Sai, Shu-Ping Hui, Yusuke Nakano, Akinori Sawamura, Tohru Inaba, Yasuhiko Sakata, Yoko Yasui, Yasuyuki Nagasawa, Shintaro Kinugawa, Kazunori Shimada, Sohsuke Yamada, Hiroyuki Hao, Daisaku Nakatani, Tomomi Ide, Tetsuya Amano, Hiroaki Naito, Hironori Nagasaka, Kunihisa Kobayashi

Orphanet journal of rare diseases　Vol. 14　No. 1　p. 134-134　2019/06/11

心筋血流脂肪酸代謝シンチ2核種同時収集におけるクロストーク補正方法

神谷 貴史, 藤埜 浩一, 平野 賢一, 千村 美里, 坂田 泰史

日本心臓核医学会ニュースレター　Vol. 21　No. 2　p. 115-115　2019/06

中性脂肪蓄積心筋血管症における心筋脂肪酸代謝シンチ洗い出し率の検討 平面像と断層像での算出比較

神谷 貴史, 平野 賢一, 藤埜 浩一, 千村 美里, 坂田 泰史

日本心臓核医学会ニュースレター　Vol. 21　No. 2　p. 134-134　2019/06

Intractable coronary artery disease in a patient with type 2 diabetes presenting with triglyceride deposit cardiomyovasculopathy

Junji Kozawa, Masahiro Higashi, Iichiro Shimomura, Ken-ichi Hirano

Diabetes Care　Vol. 42　No. 5　p. 983-986　2019/05/01　Research paper (scientific journal)

Triglyceride Deposit Cardiomyovasculopathy: A Rare Cardiovascular Disorder

Ming Li, Ken-ichi Hirano, Yoshihiko Ikeda, Masahiro Higashi, Chikako Hashimoto, Bo Zhang, Junji Kozawa, Koichiro Sugimura, Hideyuki Miyauchi, Akira Suzuki, Yasuhiro Hara, Atsuko Takagi, Yasuyuki Ikeda, Kazuhiro Kobayashi, Yoshiaki Futsukaichi, Nobuhiro Zaima, Satoshi Yamaguchi, Shrestha Rojeet, Hiroshi Nakamura, Katsuhiro Kawaguchi, Eiryu Sai, Shu-Ping Hui, Yusuke Nakano, Akinori Sawamura, Tohru Inaba, Yasuhiko Sakata, Yoko Yasui, Yasuyuki Nagasawa, Shintaro Kinugawa, Kazunori Shimada, Sohsuke Yamada, Hiroyuki Hao, Daisaku Nakatani, Tomomi Ide, Tetsuya Amano, Hiroaki Naito, Hironori Nagasaka, Kunihisa Kobayashi, on behalf of, the Japan, TGCV study group

Orphanet Journal of Rare Disease　Vol. 14　No. 1　2019/05　Research paper (scientific journal)

Triglyceride Deposit Cardiomyovasculopathy, in: T.H. Oohashi T, Ramirez F, Barber C (Ed.), “Human Pathobiochemistry

Ken-ichi Hirano

2019

Intractable Coronary Artery Disease in a Type 2 Diabetic Patient Presenting With Triglyceride Deposit Cardiomyovasculopathy

Kozawa J, Higashi M, Shimomura I, Hirano K

Diabetes Care　Vol. 42　No. 5　p. 983-986　2019/01　Research paper (scientific journal)

中性脂肪蓄積心筋血管症におけるcrosstalk補正を用いた二核種同時収集心筋脂肪酸シンチ洗い出し率の検討

神谷 貴史, 渡部 直史, 藤埜 浩一, 平野 賢一, 千村 美里, 坂田 泰史, 畑澤 順

核医学　Vol. 55　No. Suppl.　p. S185-S185　2018/11

摂食,全身代謝と生殖現象 脂質代謝と男性生殖 基礎検討からの提案

中村 仁美, 金 南孝, 正木 秀武, 熊澤 惠一, 平野 賢一, 木村 正

日本生殖医学会雑誌　Vol. 63　No. 3　p. 255-255　2018/08

Comparison of neutrophil distribution patterns in Jordans' anomaly among major automated hematology analyzers

Tohru Inaba, K. Ishizuka, A. Suzuki, S. Yuasa, K. Saito, M. Kodama, F. Hongo, N. Fujita, K. Hirano

International Journal of Laboratory Hematology　Vol. 40　No. 4　p. e78-e81　2018/08　Research paper (scientific journal)

Treatment with medium chain fatty acids milk of CD36-deficient preschool children

Hironori Nagasaka, Tohru Yorifuji, Haruki Komatsu, Tomonozumi Takatani, Ichiro Morioka, Satoshi Hirayama, Takashi Miida

Nutrition　Vol. 50　p. 45-48　2018/06　Research paper (scientific journal)

Microwave-assisted derivatization of fatty acids for its measurement in milk using high-performance liquid chromatography

Rojeet Shrestha, Yusuke Miura, Ken-Ichi Hirano, Zhen Chen, Hiroaki Okabe, Hitoshi Chiba, Shu-Ping Hui

Analytical Sciences　Vol. 34　No. 5　p. 575-582　2018/05　Research paper (scientific journal)

中性脂肪蓄積心筋血管症の冠動脈における中膜嚢胞状融解性変化についての検討

池田 善彦, 平野 賢一, 財満 信宏, 松本 学, 大郷 恵子, 植田 初江

日本病理学会会誌　Vol. 107　No. 1　p. 331-331　2018/04

Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy

Akira Suzuki, Satoshi Yamaguchi, Ming Li, Yasuhiro Hara, Hideyuki Miyauchi, Yoshihiko Ikeda, Bo Zhang, Masahiro Higashi, Yasuyuki Ikeda, Atsuko Takagi, Hironori Nagasaka, Kunihisa Kobayashi, Yasuhiro Magata, Toshiaki Aoyama

Journal of Oleo Science　Vol. 67　No. 8　p. 983-989　2018/04　Research paper (scientific journal)

Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy

Atsuko Takagi, Yasuyuki Ikeda, Kunihisa Kobayashi, Kazuhiro Kobayashi, Yoshihiko Ikeda, Junji Kozawa, Hideyuki Miyauchi, Ming Li, Chikako Hashimoto, Yasuhiro Hara, Satoshi Yamaguchi, Akira Suzuki, Tatsushi Toda, Hironori Nagasaka, Ken-ichi Hirano

Biochemical and Biophysical Research Communications　Vol. 495　No. 1　p. 646-651　2018/01/01　Research paper (scientific journal)

Change in plasma total, esterified and non-esterified capric acid concentrations during a short-term oral administration of synthetic tricaprin in dogs

Rojeet Shrestha, Ken-Ichi Hirano, Akira Suzuki, Satoshi Yamaguchi, Yusuke Miura, Yi-Fan Chen, Masahiro Mizuta, Hitoshi Chiba, Shu-Ping Hui

Analytical Sciences　Vol. 33　No. 11　p. 1297-1303　2017/11　Research paper (scientific journal)

Energy Failure Hypothesis for Takotsubo Cardiomyopathy.

Hirano K, Shimizu K, Ikeda Y, Shirakami Y, Nagasaka H

Annals of Nuclear Cardiology　Vol. 3　No. 1　p. 105-109　2017/08　Research paper (scientific journal)

Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice

Hidetake Masaki, Namhyo Kim, Hitomi Nakamura, Keiichi Kumasawa, Eriko Kamata, Ken-ichi Hirano, Tadashi Kimura

MOLECULAR HUMAN REPRODUCTION　Vol. 23　No. 7　p. 452-460　2017/07　Research paper (scientific journal)

Effect of lipid metabolism on male fertility

Namhyo Kim, Hitomi Nakamura, Hidetake Masaki, Keiichi Kumasawa, Ken-ichi Hirano, Tadashi Kimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 485　No. 3　p. 686-692　2017/04　Research paper (scientific journal)

Basic utility of Pentra series automated hematology analyzer for screening of Jordans' anomaly

T. Inaba, K. Ishizuka, A. Suzuki, S. Yuasa, K. Saito, M. Kodama, M. Hamada, F. Hongo, N. Fujita, K. -I. Hirano

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY　Vol. 39　No. 1　p. E1-E3　2017/02　Research paper (scientific journal)

Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly

Yoshihiro Kamada, Sachiho Kida, Ken-ichi Hirano, Satoshi Yamaguchi, Akira Suzuki, Chikako Hashimoto, Akihiro Kimura, Motoya Sato, Hironobu Fujii, Tomoaki Sobajima, Akiko Yamamoto, Yusuke Ebisutani, Shinji Takamatsu, Shinichiro Shinzaki, Yuichi Yoshida, Makoto Yamada, Hironori Nagasaka, Tetsuo Takehara, Eiji Miyoshi

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 311　No. 5　p. G859-G868　2016/11　Research paper (scientific journal)

Synthesis of (2 beta,3 alpha,6-H-2(3))cholesteryl linoleate and cholesteryl oleate as internal standards for mass spectrometry

Yusuke Miura, Shu-Ping Hui, Rojeet Shrestha, Takahisa Hiruma, Seiji Takeda, Hirotoshi Fuda, Shigeo Ikegawa, Ken-ichi Hirano, Hitoshi Chiba

STEROIDS　Vol. 107　p. 1-9　2016/03　Research paper (scientific journal)

Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography

Rojeet Shrestha, Shu-Ping Hui, Hiromitsu Imai, Satoru Hashimoto, Naoto Uemura, Seiji Takeda, Hirotoshi Fuda, Akira Suzuki, Satoshi Yamaguchi, Ken-ichi Hirano, Hitoshi Chiba

ANNALS OF CLINICAL BIOCHEMISTRY　Vol. 52　No. 5　p. 588-596　2015/09　Research paper (scientific journal)

Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase

Masahiro Higashi, Ken-ichi Hirano, Kazuhiro Kobayashi, Yoshihiko Ikeda, Ami Issiki, Tetsuo Otsuka, Akira Suzuki, Satoshi Yamaguchi, Nobuhiro Zaima, Seiki Hamada, Hironori Hanada, Chieko Suzuki, Hiroshi Nakamura, Hironori Nagasaka, Toshiyuki Miyata, Yoshihiro Miyamoto, Kunihisa Kobayashi, Hiroaki Naito, Tatsushi Toda

INTERNATIONAL JOURNAL OF CARDIOLOGY　Vol. 192　p. 30-32　2015/08　Research paper (scientific journal)

Cardiomyocyte steatosis and defective washout of iodine-123-beta-methyl iodophenyl-pentadecanoic acid in genetic deficiency of adipose triglyceride lipase

Ken-ichi Hirano, Yoshihiko Ikeda, Koichiro Sugimura, Yasuhiko Sakata

EUROPEAN HEART JOURNAL　Vol. 36　No. 9　p. 580-580　2015/03　Research paper (scientific journal)

Refractory hypoglycemia and subsequent cardiogenic shock in starvation and refeeding: Report of three cases

Kentaro Shimizu, Hiroshi Ogura, Masafumi Wasa, Tomoya Hirose, Takeshi Shimazu, Hironori Nagasaka, Ken-ichi Hirano

NUTRITION　Vol. 30　No. 9　p. 1090-1092　2014/09　Research paper (scientific journal)

Coronary triglyceride deposition in contemporary advanced diabetics

Yoshihiko Ikeda, Nobuhiro Zaima, Ken-ichi Hirano, Masayuki Mano, Kunihisa Kobayashi, Sohsuke Yamada, Satoshi Yamaguchi, Akira Suzuki, Hideaki Kanzaki, Toshimitsu Hamasaki, Jun-ichi Kotani, Seiya Kato, Hironori Nagasaka, Mitsutoshi Setou, Hatsue Ishibashi-Ueda

PATHOLOGY INTERNATIONAL　Vol. 64　No. 7　p. 325-335　2014/07　Research paper (scientific journal)

A novel mutation in PNPLA2 causes neutral lipid storage disease with myopathy and triglyceride deposit cardiomyovasculopathy: A case report and literature review

Kimihiko Kaneko, Hiroshi Kuroda, Rumiko Izumi, Maki Tateyama, Masaaki Kato, Koichiro Sugimura, Yasuhiko Sakata, Yoshihiko Ikeda, Ken-ichi Hirano, Masashi Aoki

NEUROMUSCULAR DISORDERS　Vol. 24　No. 7　p. 634-641　2014/07　Research paper (scientific journal)

Changes of lipoproteins in phenylalanine hydroxylase-deficient children during the first year of life

Hironori Nagasaka, Hirokazu Tsukahara, Yoshiyuki Okano, Ken-ichi Hirano, Toshihiro Sakurai, Shu-Ping Hui, Toshihiro Ohura, Hiromi Usui, Tohru Yorifuji, Satoshi Hirayama, Akira Ohtake, Takashi Miida

CLINICA CHIMICA ACTA　Vol. 433　p. 1-4　2014/06　Research paper (scientific journal)

Disease-associated marked hyperalphalipoproteinemia

Ken-Ichi Hirano, Hironori Nagasaka, Kazuhiro Kobayashi, Satoshi Yamaguchi, Akira Suzuki, Tatsushi Toda, Manabu Doyu

Molecular Genetics and Metabolism Reports　Vol. 1　No. 1　p. 264-268　2014/06　Research paper (scientific journal)

Peripheral leukocyte anomaly detected with routine automated hematology analyzer sensitive to adipose triglyceride lipase deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy

Akira Suzuki, Hironori Nagasaka, Yasuhiro Ochi, Kazuhiro Kobayashi, Hiroshi Nakamura, Daisaku Nakatani, Satoshi Yamaguchi, Shinobu Yamaki, Atsushi Wada, Yoshihisa Shirata, Shu-Ping Hui, Tatsushi Toda, Hiroshi Kuroda, Hitoshi Chiba, Ken-Ichi Hirano

Molecular Genetics and Metabolism Reports　Vol. 1　No. 1　p. 249-253　2014/05　Research paper (scientific journal)

Selective evaluation of high density lipoprotein from mouse small intestine by an in situ perfusion technique

Satoshi Yamaguchi, Bo Zhang, Takeshi Tomonaga, Utako Seino, Akiko Kanagawa, Masaru Segawa, Hironori Nagasaka, Akira Suzuki, Takashi Miida, Sohsuke Yamada, Yasuyuki Sasaguri, Takefumi Doi, Keijiro Saku, Mitsuyo Okazaki, Yoshihiro Tochino, Ken-ichi Hirano

JOURNAL OF LIPID RESEARCH　Vol. 55　No. 5　p. 905-918　2014/05　Research paper (scientific journal)

A novel type of human spontaneous coronary atherosclerosis with triglyceride deposition

Yoshihiko Ikeda, Ken-ichi Hirano, Norihide Fukushima, Yoshiki Sawa

EUROPEAN HEART JOURNAL　Vol. 35　No. 13　p. 875-875　2014/04　Research paper (scientific journal)

Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-gamma in patients with triglyceride deposit cardiomyovasculopathy

Ken-ichi Hirano, Tatsuya Tanaka, Yoshihiko Ikeda, Satoshi Yamaguchi, Nobuhiro Zaima, Kazuhiro Kobayashi, Akira Suzuki, Yasuhiko Sakata, Yasushi Sakata, Kunihisa Kobayashi, Tatsushi Toda, Norihide Fukushima, Hatsue Ishibashi-Ueda, Daniela Tavian, Hironori Nagasaka, Shu-Ping Hui, Hitoshi Chiba, Yoshiki Sawa, Masatsugu Hori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 443　No. 2　p. 574-579　2014/01　Research paper (scientific journal)

Quantitative proteomic analysis of cultured skin fibroblast cells derived from patients with triglyceride deposit cardiomyovasculopathy

Yasuhiro Hara, Naoko Kawasaki, Ken-Ichi Hirano, Yuuki Hashimoto, Jun Adachi, Shio Watanabe, Takeshi Tomonaga

Orphanet Journal of Rare Diseases　Vol. 8　No. 1　2013/12/21　Research paper (scientific journal)

生活習慣病の男性生殖能に与える影響 2型糖尿病モデルマウスを用いた検討(The effect of lifestyle related diseases on male fertility: A study using type 2 diabetes model mice)

金 南孝, 中村 仁美, 正木 秀武, 古屋 毅一郎, 三宅 達也, 熊澤 恵一, 筒井 建紀, 平野 賢一, 木村 正

Reproductive Immunology and Biology　Vol. 28　No. 1-2　p. 90-90　2013/11

[Triglyceride deposit cardiomyovasculopathy].

Ken-ichi Hirano

Nihon rinsho. Japanese journal of clinical medicine　2013/09/01　Research paper (scientific journal)

Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice

Tomoaki Inoue, Kunihisa Kobayashi, Toyoshi Inoguchi, Noriyuki Sonoda, Yasutaka Maeda, Eiichi Hirata, Yoshinori Fujimura, Daisuke Miura, Ken-ichi Hirano, Ryoichi Takayanagi

Biochemical and Biophysical Research Communications　Vol. 438　No. 1　p. 224-229　2013/08/16　Research paper (scientific journal)

Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity

Yanhui Lin, Shunmei Chiba, Akira Suzuki, Satoshi Yamaguchi, Takaya Nakanishi, Hirofumi Matsumoto, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Ken-Ichi Hirano, Seiya Kato

Biochemical and Biophysical Research Communications　Vol. 434　No. 3　p. 534-540　2013/05/10　Research paper (scientific journal)

Metabolic improvements in intrahepatic porto-systemic venous shunt presenting various metabolic abnormalities by 4-phenylacetate

Hironori Nagasaka, Takashi Miida, Tohru Yorifuji, Ken-ichi Hirano, Ayano Inui, Tomoo Fujisawa, Hirokazu Tsukahara, Hisamitsu Hayashi, Yukihiro Inomata

CLINICA CHIMICA ACTA　Vol. 419　p. 52-56　2013/04　Research paper (scientific journal)

iPS Cell Modeling of Cardiometabolic Diseases

Kenta Nakamura, Sean M. Wu

Journal of Cardiovascular Translational Research　Vol. 6　No. 1　p. 46-53　2013/02　Research paper (scientific journal)

Oxysterol changes along with cholesterol and vitamin D changes in adult phenylketonuric patients diagnosed by newborn mass-screening

Hironori Nagasaka, Yoshiyuki Okano, Akihiko Kimura, Tatsuki Mizuochi, Yoshitami Sanayama, Tomozumi Takatani, Saori Nakagawa, Eri Hasegawa, Ken-ichi Hirano, Hiroshi Mochizuki, Toshihiro Ohura, Mika Ishige-Wada, Hiromi Usui, Tohru Yorifuji, Hirokazu Tsukahara, Satoshi Hirayama, Akira Ohtake, Susumu Yamato, Takashi Miida

CLINICA CHIMICA ACTA　Vol. 416　p. 54-59　2013/02　Research paper (scientific journal)

Sustained high plasma mannose less sensitive to fluctuating blood glucose in glycogen storage disease type Ia children

Hironori Nagasaka, Tohru Yorifuji, Robert H. J. Bandsma, Tomozumi Takatani, Hisaki Asano, Hiroshi Mochizuki, Mayuko Takuwa, Hirokazu Tsukahara, Ayano Inui, Tomoyuki Tsunoda, Haruki Komatsu, Eitaro Hiejima, Tomoo Fujisawa, Ken-Ichi Hirano, Takashi Miida, Akira Ohtake, Tadao Taguchi, Ichitomo Miwa

Journal of Inherited Metabolic Disease　Vol. 36　No. 1　p. 75-81　2013/01　Research paper (scientific journal)

2型糖尿病関連中性脂肪蓄積心筋血管症

平野 賢一, 池田 善彦, 財満 信宏, 眞能 正幸, 小林 邦久, 神崎 秀明, 加藤 誠也, 笹栗 靖之, 友池 仁暢, 瀬藤 光利, 植田 初江

日本病理学会会誌　Vol. 101　No. 1　p. 283-283　2012/03

我が国で見いだされた新規疾患単位、中性脂肪蓄積心筋血管症 希少難病からcommon diseaseへの展開

平野 賢一, 財満 信宏, 池田 善彦, 眞能 正幸, 小林 邦久, 神崎 秀明, 北風 政史, 小室 一成, 瀬藤 光利, 友池 仁暢

日本内科学会雑誌　Vol. 101　No. Suppl.　p. 229-229　2012/02

Biomarker Discovery for Triglyceride Deposit Cardiomyovasculopathy using Proteomics and Transcriptomics.

kawasaki naoko, Hirano Kenichi, Hara Yasuhiro, Adachi Jun, Watanabe Shio, Tomonaga Takeshi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2012　p. 98-98　2012

Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor alpha-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-kappa B

Tomoaki Inoue, Kunihisa Kobayashi, Toyoshi Inoguchi, Noriyuki Sonoda, Masakazu Fujii, Yasutaka Maeda, Yoshinori Fujimura, Daisuke Miura, Ken-ichi Hirano, Ryoichi Takayanagi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 37　p. 32045-32053　2011/09　Research paper (scientific journal)

CD36 deficiency predisposing young children to fasting hypoglycemia

Hironori Nagasaka, Tohru Yorifuji, Tomozumi Takatani, Yoshiyuki Okano, Hirokazu Tsukahara, Hidekatsu Yanai, Ken-ichi Hirano, Shu-Ping Hui, Satoshi Hirayama, Tetsuya Ito, Hitoshi Chiba, Takashi Miida

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 60　No. 6　p. 881-887　2011/06　Research paper (scientific journal)

Histamine Deficiency Decreases Atherosclerosis and Inflammatory Response in Apolipoprotein E Knockout Mice Independently of Serum Cholesterol Level

Ke-Yong Wang, Akihide Tanimoto, Xin Guo, Sohsuke Yamada, Shohei Shimajiri, Yoshitaka Murata, Yan Ding, Masato Tsutsui, Seiya Kato, Teruo Watanabe, Hiroshi Ohtsu, Ken-Ichi Hirano, Kimitoshi Kohno, Yasuyuki Sasaguri

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 31　No. 4　p. 800-807　2011/04　Research paper (scientific journal)

Biomarker Discovery for Triglyceride Deposit Cardiomyovasculopathy using Proteome and Transcriptome Analysis.

Kawasaki Naoko, Hirano Kenichi, Hara Yasuhiro, Adachi Jun, Tomonaga Takeshi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2011　p. 114-114　2011

Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors Model for Nonalcoholic Steatohepatitis in Mice

Ke-Yong Wang, Akihide Tanimoto, Sohsuke Yamada, Xin Guo, Yan Ding, Teruo Watanabe, Takeshi Watanabe, Kimitoshi Kohno, Ken-Ichi Hirano, Hideo Tsukada, Yasuyuki Sasaguri

AMERICAN JOURNAL OF PATHOLOGY　Vol. 177　No. 2　p. 713-723　2010/08　Research paper (scientific journal)

Altered metabolisms of mediators controlling vascular function and enhanced oxidative stress in asymptomatic children with congenital portosystemic venous shunt

Hironori Nagasaka, Yoshiyuki Okano, Madoka Aizawa, Takashi Miida, Tohru Yorifuji, Go Tajima, Nobuo Sakura, Tomozumi Takatani, Yoshitami Sanayama, Kenji Sugamoto, Mitsufumi Mayumi, Kunihiko Kobayashi, Kenichi Hirano, Masaki Takayanagi, Hirokazu Tsukaharah

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 59　No. 1　p. 107-113　2010/01　Research paper (scientific journal)

A Novel Clinical Entity: Triglyceride Deposit Cardiomyovasculopathy

Ken-ichi Hirano

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 16　No. 5　p. 702-705　2009/10　Research paper (scientific journal)

Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and I14A, during the first year of life

Hironori Nagasaka, Tohru Yorifuji, Toru Momoi, Junko Yorifuji, Kenichi Hirano, Akemi Ota, Tomozumi Takatani, Hirokazu Tsukahara, Masaki Takayanagi, Kunihiko Kobayashi, Hitoshi Chiba, Yukiyasu Sato, Takashi Miida

CLINICA CHIMICA ACTA　Vol. 406　No. 1-2　p. 52-56　2009/08　Research paper (scientific journal)

Sterol-mediated Regulation of Human Lipin 1 Gene Expression in Hepatoblastoma Cells

Kenji Ishimoto, Hiroki Nakamura, Keisuke Tachibana, Daisuke Yamasaki, Akemi Ota, Ken-ichi Hirano, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 33　p. 22195-22205　2009/08　Research paper (scientific journal)

Fibrinogen storage disease caused by aguadilla mutation presenting with hypobeta-lipoproteinemia and considerable liver disease

Tsuyoshi Sogo, Hironori Nagasaka, Haruki Komatsu, Ayano Inui, Takashi Miida, Francesco Callea, Paola Francalanci, Ken-Ichi Hirano, Hajime Kitamura, Toru Yorifuji, Tomoo Fujisawa

Journal of Pediatric Gastroenterology and Nutrition　Vol. 49　No. 1　p. 133-136　2009/07　Research paper (scientific journal)

Impaired Insulin Secretion in Four Tangier Disease Patients with ABCA1 Mutations

Masahiro Koseki, Akifumi Matsuyama, Kazuhiro Nakatani, Miwako Inagaki, Hajime Nakaoka, Ryota Kawase, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Daisaku Masuda, Jose C. Sandoval, Tohru Ohama, Yumiko Nakagawa-Toyama, Fumihiko Matsuura, Makoto Nishida, Masato Ishigami, Ken-ichi Hirano, Naoki Sakane, Yoshitaka Kumon, Tadashi Suehiro, Tadashi Nakamura, Iichiro Shimomura, Shizuya Yamashita

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 16　No. 3　p. 292-296　2009/06　Research paper (scientific journal)

Sustaining hypercitrullinemia, hypercholesterolemia and augmented oxidative stress in Japanese children with aspartate/glutamate carrier isoform 2-citrin-deficiency even during the silent period

Hironori Nagasaka, Yoshiyuki Okano, Hirokazu Tsukahara, Yosuke Shigematsu, Toru Momoi, Junko Yorifuji, Takashi Miida, Toshihiro Ohura, Keiko Kobayashi, Takeyori Saheki, Kenichi Hirano, Masaki Takayanagi, Tohru Yorifuji

MOLECULAR GENETICS AND METABOLISM　Vol. 97　No. 1　p. 21-26　2009/05　Research paper (scientific journal)

Chylomicron remnants are increased in the postprandial state in CD36 deficiency

Daisaku Masuda, Ken-ichi Hirano, Hiroyuki Oku, Jose C. Sandoval, Ryota Kawase, Miyako Yuasa-Kawase, Yasushi Yamashita, Masanori Takada, Kazumi Tsubakio-Yamamoto, Yoshihiro Tochino, Masahiro Koseki, Fumihiko Matsuura, Makoto Nishida, Toshiharu Kawamoto, Masato Ishigami, Masatsugu Hori, Iichiro Shimomura, Shizuya Yamashita

JOURNAL OF LIPID RESEARCH　Vol. 50　No. 5　p. 999-1011　2009/05　Research paper (scientific journal)

Effects of bezafibrate on dyslipidemia with cholestasis in children with familial intrahepatic cholestasis-1 deficiency manifesting progressive familial intrahepatic cholestasis

Hironori Nagasaka, Tohru Yorifuji, Kenichi Hirano, Akemi Otac, Yumiko Toyama-Nakagawa, Tomozumi Takatani, Hirokazu Tsukahara, Kunihiko Kobayashi, Masaki Takayanagi, Yukihiro Inomata, Shinji Uemoto, Takashi Miida

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 58　No. 1　p. 48-54　2009/01　Research paper (scientific journal)

Triglyceride Deposit Cardiomyovasculopathy

Yoshihiko Ikeda, Nobuhiro Zaima, Yasuhiko Sakata, Goro Matsumiya

New England Journal of Medicine　Vol. 359　No. 22　p. 2396-2398　2008/11/27　Research paper (scientific journal)

Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome

Hironori Nagasaka, Takashi Miida, Ken-ichi Hirano, Akemi Ota, Kei Murayama, Tohru Yorifuji, Kunihiko Kobayashi, Tornommi Takatani, Hirokazu Tsukahara, Shu-Ping Hui, Masaki Takayanagi, Hitoshi Chiba

ATHEROSCLEROSIS　Vol. 198　No. 2　p. 434-440　2008/06　Research paper (scientific journal)

Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial Hypercholesterolemia in the first year of life

Hironori Nagasaka, Takashi Miida, Kenichi Hirano, Akemi Ota, Tohru Yorifuji, Tomozumi Takatani, Hirokazu Tsukahara, Masaki Takayanagi, Shu-Ping Hui, Kunihiko Kobayashi, Hitoshi Chiba

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　Vol. 93　No. 3　p. 779-783　2008/03　Research paper (scientific journal)

Improvements of hypertriglyceridemia and hyperlacticemia in Japanese children with glycogen storage disease type Ia by medium-chain triglyceride milk

Hironori Nagasaka, Ken-Ichi Hirano, Akira Ohtake, Takashi Miida, Tomozumi Takatani, Kei Murayama, Tohru Yorifuji, Kunihiko Kobayashi, Masaki Kanazawa, Atsushi Ogawa, Masaki Takayanagi

European Journal of Pediatrics　Vol. 166　No. 10　p. 1009-1016　2007/10　Research paper (scientific journal)

Adiponectin deficiency suppresses ApoA-I synthesis in ABCA1 expression and the liver

Hiroyuki Oku, Fumihiko Matsuura, Masahiro Koseki, Jose C. Sandoval, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Daisaku Masuda, Norikazu Maeda, Tohru Ohama, Masato Ishigami, Makoto Nishida, Ken-Ichi Hirano, Shinji Kihara, Masatsugu Hori, Iichiro Shimomura, Shizuya Yamashita

FEBS LETTERS　Vol. 581　No. 26　p. 5029-5033　2007/10　Research paper (scientific journal)

Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver

Fumihiko Matsuura, Hiroyuki Oku, Masahiro Koseki, Jose C. Sandoval, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Daisaku Masuda, Norikazu Maeda, Ken-ichi Tsujii, Masato Ishigami, Makoto Nishida, Ken-ichi Hirano, Shinji Kihara, Masatsugu Hori, Iichiro Shimomura, Shizuya Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 358　No. 4　p. 1091-1095　2007/07　Research paper (scientific journal)

Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis

Hironori Nagasaka, Hitoshi Chiba, Shu-Ping Hui, Hajime Takikawa, Takashi Miida, Masaki Takayanagi, Tohru Yorifuji, Makoto Hasegawa, Akemi Ota, Ken-ichi Hirano, Hideaki Kikuchi, Hirokazu Tsukahara, Kunihiko Kobayashi

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION　Vol. 45　No. 1　p. 96-105　2007/07　Research paper (scientific journal)

Senescent phenotypes of skin fibroblasts from patients with Tangier disease

Fumihiko Matsuura, Ken-ichi Hirano, Chiaki Ikegami, Jose C. Sandoval, Hiroyuki Oku, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Masahiro Koseki, Daisaku Masuda, Ken-ichi Tsujii, Masato Ishigami, Makoto Nishida, Iichiro Shimomura, Masatsugu Hori, Shizuya Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 357　No. 2　p. 493-498　2007/06　Research paper (scientific journal)

Aggregated ursolic acid, a natural triterpenoid, induces IL-1β release from murine peritoneal macrophages: Role of CD36

Yasutaka Ikeda, Akira Murakami, Yoshinori Fujimura, Hirofumi Tachibana, Koji Yamada, Daisaku Masuda, Ken-Ichi Hirano, Shizuya Yamashita, Hajime Ohigashi

Journal of Immunology　Vol. 178　No. 8　p. 4854-4864　2007/04/15　Research paper (scientific journal)

OE-079 HDL-mediated Plaque Stabilization through Enhancement of Cholesterol Efflux and Inhibition of a Novel Proinflammatory Cytokine Proepithelin(Atherosclerosis, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Yamashita Shizuya, Matsuyama Akifumi, Koseki Masahiro, Masuda Daisaku, Matsuura Fumihiko, Hirano Kenichi, Hori Masatsugu, Shimomura Iichiro

Circulation journal : official journal of the Japanese Circulation Society　Vol. 71　No. 0　p. 171-171　2007/03/01

Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages

Masahiro Koseki, Ken-ichi Hirano, Daisaku Masuda, Chiaki Ikegami, Masaki Tanaka, Akemi Ota, Jose C. Sandoval, Yumiko Nakagawa-Toyama, Satoshi B. Sato, Toshihide Kobayashi, Yukiko Shimada, Yoshiko Ohno-Iwashita, Fumihiko Matsuura, Iichiro Shimomura, Shizuya Yamashita

JOURNAL OF LIPID RESEARCH　Vol. 48　No. 2　p. 299-306　2007/02　Research paper (scientific journal)

OE-060 Apo B-48 Is a Good Marker for Coronary Risk and Impaired Metabolism of Chylomicron Remnants in Subjects with Metabolic Syndrome(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Yamashita Shizuya, Sugimoto Taizo, Nishida Makoto, Ishigami Masato, Kirino Motohiro, Masuda Daisaku, Koseki Masahiro, Toyama Yumiko, Matsuyama Akifumi, Hirano Ken-ichi, Hori Masatsugu, Sakai Naohiko, Matsumoto Kengo, Kawamoto Toshiharu, Uchida Yoshiaki

Circulation journal : official journal of the Japanese Circulation Society　Vol. 70　No. 0　p. 163-163　2006/03/01

Accumulation of chylomicron remnants in diabetic patients in relation to coronary heart disease - Analysis by a novel ELISA for apo B-48

S. Yamashita, T. Sugimoto, K. Tsujii, M. Koseki, M. Nishida, K. Hirano, I. Shimomura, Y. Uchida, N. Sakai

ADVANCES IN HEART DISEASE　p. 305-+　2006　Research paper (international conference proceedings)

Fasting serum apolipoprotein B-48 level measured by novel ELISA is a good marker of postprandial hyperlipidemia and predicts coronary heart disease

S. Yamashita, T. Sugimoto, K. Tsujii, M. Nishida, K. Hirano, I. Shimomura, K. Matsumoto, T. Kawamoto, Y. Masuda, A. Ikeda, T. Okuno, Y. Uchida, N. Sakai

ADVANCES IN HEART DISEASE　p. 297-+　2006　Research paper (international conference proceedings)

Physiological roles of a multi-ligand receptor CD36 in atherogenesis; Insights from human CD36 deficiency

S. Yamashita, D. Masuda, T. Kuwasako, M. Janabi, N. Sakai, I. Shimomura, K. Hirano

ADVANCES IN HEART DISEASE　p. 315-+　2006　Research paper (international conference proceedings)

Cell surface-expressed moesin-like HDL/apoA-I binding protein promotes cholesterol efflux from human macrophages

A Matsuyama, N Sakai, H Hiraoka, K Hirano, S Yamashita

JOURNAL OF LIPID RESEARCH　Vol. 47　No. 1　p. 78-86　2006/01　Research paper (scientific journal)

Probucol Enhances the Expression of Human Hepatic Scavenger Receptor Class B Type I, Possibly Through a Species-Specific Mechanism

Chiaki Ikegami, Ken-ichi Tsujii, Zhongyan Zhang, Fumihiko Matsuura, Yumiko Nakagawa-Toyama, Masahiro Koseki, Daisaku Masuda, Takao Maruyama, Iichiro Shimomura, Yukihiko Ueda, Shizuya Yamashita

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 25　No. 11　p. 2422-2427　2005/11　Research paper (scientific journal)

Human scavenger receptor class B type I is expressed with cell-specific fashion in both initial and terminal site of reverse cholesterol transport

Y Nakagawa-Toyama, K Hirano, K Tsujii, M Nishida, J Miyagawa, N Sakai, S Yamashita

ATHEROSCLEROSIS　Vol. 183　No. 1　p. 75-83　2005/11　Research paper (scientific journal)

Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux

F Matsuura, K Hirano, M Koseki, T Ohama, A Matsuyama, K Tsujii, R Komuro, M Nishida, N Sakai, H Hiraoka, T Nakamura, S Yamashita

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 54　No. 8　p. 1095-1101　2005/08　Research paper (scientific journal)

Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase

ZY Zhang, K Hirano, K Tsukamoto, C Ikegami, M Koseki, K Saijo, T Ohno, N Sakai, H Hiraoka, L Shimomura, S Yamashita

EXPERIMENTAL GERONTOLOGY　Vol. 40　No. 4　p. 286-294　2005/04　Research paper (scientific journal)

Molecular Mechanisms of Cholesteryl Ester Transfer Protein Deficiency in Japanese

Makoto Nagano, Shizuya Yamashita, Mayumi Takano, Takao Maruyama, Mitsuaki Ishihara, Yukiko Sagehashi, Takeshi Kujiraoka, Kazuya Tanaka, Hiroaki Hattori, Naohiko Sakai, Norimichi Nakajima, Tohru Egashira, Yuji Matsuzawa

Journal of Atherosclerosis and Thrombosis　Vol. 11　No. 3　p. 110-121　2004/03　Research paper (scientific journal)

ヒト腸管上皮の血管側表面におけるATP結合カセット輸送体A1の優位発現(Dominant Expression of ATP binding cassette transporter A1 on basolateral surface of human intestinal epithelium)

大濱 透, 平野 賢一, 張 仲衍, 外山 裕美子, 松山 晃文, 石神 眞人, 酒井 尚彦, 植田 和光, 山下 静也, 松澤 佑次

日本動脈硬化学会総会プログラム・抄録集　Vol. 35回　p. 188-188　2003/09

ATP結合カセットA1仲介コレステロール流出には小胞酸性化が必要である(Vesicular Acidification is Required for ATP-binding Cassette Transporter Al-mediated Cholesterol Efflux)

小関 正博, 松山 晃文, 酒井 尚彦, 大濱 透, 西田 義治, 平野 賢一, 平岡 久豊, 中村 正, 山下 静也, 松澤 佑次

日本動脈硬化学会総会プログラム・抄録集　Vol. 35回　p. 188-188　2003/09

血中MMP値は大動脈炎症候群の診断とその活動性評価の指標として有用である

松山 晃文, 酒井 尚彦, 石神 眞人, 平岡 久豊, 樫根 晋, 平田 歩, 平野 賢一, 中村 正, 山下 静也, 松澤 佑次

日本動脈硬化学会総会プログラム・抄録集　Vol. 35回　p. 205-205　2003/09

Atorvastatin markedly improves type III hyperlipoproteinemia in association with reduction of both exogenous and endogenous apolipoprotein B-containing lipoproteins

Ishigami M, Yamashita S, Sakai N, Hirano K, Hiraoka H, Nakamura T, Matsuzawa Y

Atherosclerosis　Vol. 168　No. 2　p. 359-366　2003/06　Research paper (scientific journal)

Lipoprotein abnormalities in human genetic CD36 deficiency associated with insulin resistance and abnormal fatty acid metabolism

T Kuwasako, K Hirano, N Sakai, M Ishigami, H Hiraoka, MJ Yakub, K Yamauchi-Takihara, S Yamashita, Y Matsuzawa

DIABETES CARE　Vol. 26　No. 5　p. 1647-1648　2003/05　Research paper (scientific journal)

Vesicular Acidification Is Required for ATP-Binding Cassette Transporter A1-Mediated Cholesterol Efflux

Koseki Masahiro, Matsuyama Akifumi, Sakai Naohiko, Ohama Toru, Nishida Yoshiharu, Hirano Kenichi, Hiraoka Hisatoyo, Nakamura Tadashi, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 67　No. 0　p. 490-490　2003/03/01

Measurement of Cholesterol Efflux from Monocyte-Derived Macrophages of Patients with Llpid Disorders and Atherosclerotic Cardiovascular Diseases

Tsujii Kenichi, Hirano Kenichi, Zhang Zhongyan, Matsuura Fumihiko, Ohama Tohru, Kuwasako Takahiro, Koseki Masahiro, Matsuyama Akifumi, Tsukamoto Kosuke, Toyama Yumiko, Tachibana Koichi, Ishigami Masato, Sakai Naohiko, Hiraoka Hisatoyo, Nakamura Tadashi, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 67　No. 0　p. 449-449　2003/03/01

A Possible Major Source of Plasma HDL Particles : Role of ATP Binding Cassette A1 (ABCA1) in Human Intestines

Ohama Tohru, Hirano Kenichi, Zhang Zhongyan, Tsujii Kenichi, Toyama Yumiko, Tsukamoto Kosuke, Matsuyama Akifumi, Ishigami Masato, Sakai Naohiko, Hiraoka Hisatoyo, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 67　No. 0　p. 400-400　2003/03/01

Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia

T Maruyama, N Sakai, M Ishigami, K Hirano, T Arai, S Okada, E Okuda, A Ohya, N Nakajima, K Kadowaki, E Fushimi, S Yamashita, Y Matsuzawa

ATHEROSCLEROSIS　Vol. 166　No. 1　p. 177-185　2003/01　Research paper (scientific journal)

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

Cheryl L. Wellington, Yu-Zhou Yang, Stephen Zhou, Susanne M. Clee, Bing Tan, Kenichi Hirano, Karin Zwarts, Anita Kwok, Allison Gelfer, Michel Marcil, Scott Newman, Kirsten Roomp, Roshni Singaraja, Jennifer Collins, Lin-Hua Zhang, Albert K. Groen, Kees Hovingh, Alison Brownlie, Sherrie Tafuri, Jacques Genest, John J.P. Kastelein, Michael R. Hayden

Journal of Lipid Research　Vol. 43　No. 11　p. 1939-1949　2002/11　Research paper (scientific journal)

Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts - A possible function of Cdc42 in mediating intracellular lipid transport

K Tsukamoto, K Hirano, S Yamashita, N Sakai, C Ikegami, ZY Zhang, F Matsuura, H Hiraoka, A Matsuyama, M Ishigami, Y Matsuzawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 22　No. 11　p. 1899-1904　2002/11　Research paper (scientific journal)

Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions

Youichiro Wada, Akira Sugiyama, Takashi Yamamoto, Makoto Naito, Noriko Noguchi, Shinji Yokoyama, Maki Tsujita, Yoshiki Kawabe, Mika Kobayashi, Akashi Izumi, Takahide Kohro, Toshiya Tanaka, Hirokazu Taniguchi, Hidenori Koyama, Ken-Ichi Hirano, Shizuya Yamashita, Yuji Matsuzawa, Etsuo Niki, Takao Hamakubo, Tatsuhiko Kodama

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 22　No. 10　p. 1712-1719　2002/10/01　Research paper (scientific journal)

Distribution of human plasma PLTP mass and activity in hypo- and hyperalphalipoproteinemia

Oka T, Yamashita S, Kujiraoka T, Ito M, Nagano M, Sagehashi Y, Egashira T, Nanjee MN, Hirano K, Miller NE, Matsuzawa Y, Hattori H

J Lipid Res　Vol. 43　No. 8　p. 1236-1243　2002/08　Research paper (scientific journal)

Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands

T Ohama, K Hirano, ZY Zhang, R Aoki, K Tsujii, Y Nakagawa-Toyama, K Tsukamoto, C Ikegami, A Matsuyama, M Ishigami, N Sakai, H Hiraoka, K Ueda, S Yamashita, Y Matsuzawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 296　No. 3　p. 625-630　2002/08　Research paper (scientific journal)

Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader (R) assay

M Nagano, S Yamashita, K Hirano, M Ito, T Maruyama, M Ishihara, Y Sagehashi, T Oka, T Kujiraoka, H Hattori, N Nakajima, T Egashira, M Kondo, N Sakai, Y Matsuzawa

JOURNAL OF LIPID RESEARCH　Vol. 43　No. 7　p. 1011-1018　2002/07　Research paper (scientific journal)

コレステロール逆転送分子機構の新展開 コレステロール逆転送系(RCT)におけるCdc42-ABCA1システムの意義とそれを用いたRCT賦活治療の可能性

平野 賢一, 塚本 幸資, 松浦 文彦, 西田 義治, 張 仲衍, 大濱 透, 松山 晃文, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 102-102　2002/06

HDL欠損症患者に新規に発見されたATP-Binding Cassette Transporter-1(ABAC1)変異体の発現及び機能解析

西田 義治, 平野 賢一, 塚本 幸資, 長野 誠, 張 仲衍, 松山 晃文, 大濱 透, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 158-158　2002/06

ABCG5に新規遺伝子変異を見いだしたシトステロール血症の検討

小関 正博, 松山 晃文, 長野 誠, 服部 浩明, 江頭 徹, 杉本 泰造, 平野 賢一, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 167-167　2002/06

ABCA1に新規遺伝子変異を見出しえた家族性HDL欠損症(FHD)の1症例

大橋 浩二, 松山 晃文, 多田 久也, 長野 誠, 服部 浩明, 江頭 徹, 平野 賢一, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 167-167　2002/06

Apolipoprotein A-I遺伝子変異による顕著な低HDL血症の1症例

松山 晃文, 酒井 尚彦, 葛谷 雅文, 長野 誠, 服部 浩明, 江頭 徹, 平野 賢一, 平岡 久豊, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 168-168　2002/06

タンジール病患者由来皮膚線維芽細胞はpremature replicative senescenceの表現型を示す

松浦 文彦, 平野 賢一, 塚本 幸資, 松山 晃文, 酒井 尚彦, 平岡 久豊, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 195-195　2002/06

Minocyclineは大動脈炎症候群の治療に有効であり,その機序はMMP活性抑制作用を介する

松山 晃文, 石神 眞人, 平岡 久豊, 樫根 晋, 平田 歩, 平野 賢一, 酒井 尚彦, 中村 正, 山下 静也, 松澤 佑次

動脈硬化　No. 34回抄集　p. 205-205　2002/06

Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs

Shrikant Anant, Debnath Mukhopadhyay, Thomas A. Brasitus, Nicholas O. Davidson

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression　Vol. 1575　No. 1-3　p. 54-62　2002/05　Research paper (scientific journal)

Expression and Functional analyses of Novel Mutations of ATP-binding Cassette Transporter-1 in Japanese Patients with High Density lipoprotein Deficiency

Nishida Yoshiharu, Ohama Tohru, Hirano Kenichi, Tsukamoto Kosuke, Zhang Zhongyan, Matsuyama Akifumi, Tsujii Kenichi, Matsuura Fumihiko, Ishigami Masato, Sakai Naohiko, Hiraoka Hisatoyo, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 676-676　2002/03/31

Premature replicative senescence in skin fibroblasts from Tangier disease

Matsuura Fumihiko, Hirano Kenichi, Tsukamoto Kosuke, Matsuyama Akifumi, Sakai Naohiko, Hiraoka Hisatoyo, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 412-412　2002/03/31

Serum Matrix Metalloproteinases (MMPs) Levels Are Diagnostic Markers of Active Phase in Patients with Takayasu Arteritis

Matsuyama Akifumi, Ishigami Masato, Hiraoka Hisatoyo, Kashine Susumu, Hirata Ayumu, Hirano Kenichi, Sakai Naohiko, Nakamura Tadashi, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 260-260　2002/03/31

Cell-Surface Expressed Moesin-Like HDL/Apo A-I Binding Protein Is Involved in Cholesterol Efflux from Human Monocyte-derived Macrophages

Matsuyama Akifumi, Sakai Naohiko, Sugimoto Taizo, Matsuura Fumihiko, Ishigami Masato, Hirano Kenichi, Hiraoka Hisatoyo, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 154-154　2002/03/31

Expression of Cholesteryl Ester Transfer Protein in Human Atherosclerotic Lesions and Its Implication in Reverse Cholesterol Transport

Zhang Zhongyan, Yamashita Shizuya, Hirano Ken-ichi, Nakagawa-Toyama Yumiko, Matsuyama Akifumi, Nishida Makoto, Ishigami Masato, Sakai Naohiko, Miyagawa Jun-ichiro, Matsuzawa Yuji, Fukasawa Masayoshi, Arai Hiroyuki

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 120-120　2002/03/31

Minocycline Has a Steroid-Sparing Effect in Treatment of Takayasu Arteritis

Matsuyama Akifumi, Ishigami Masato, Hiraoka Hisatoyo, Kashine Susumu, Hirata Ayumu, Hirano Kenichi, Sakai Naohiko, Nakamura Tadashi, Yamashita Shizuya, Matsuzawa Yuji

Circulation journal : official journal of the Japanese Circulation Society　Vol. 66　No. 0　p. 111-111　2002/03/31

Minocyclineは大動脈炎症候群の治療に有効であり,その機序はMMP活性抑制作用を介する

松山 晃文, 石神 眞人, 平岡 久豊, 樫根 晋, 平田 歩, 平野 賢一, 酒井 尚彦, 中村 正, 山下 静也, 松沢 佑次

日本内科学会雑誌　Vol. 91　No. 臨増　p. 195-195　2002/02

Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats

T Sugimoto, S Yamashita, M Ishigami, N Sakai, K Hirano, M Tahara, K Matsumoto, T Nakamura, Y Matsuzawa

JOURNAL OF HEPATOLOGY　Vol. 36　No. 2　p. 157-162　2002/02　Research paper (scientific journal)

How a receptor for oxidized low density lipoproteins works in human. Insights from human genetic CD36 deficiency

K Hirano, T Kuwasako, Y Nakagawa-Toyama, T Sugimoto, M Ishigami, N Sakai, H Hiraoka, S Yamashita, Y Matsuzawa

ATHEROSCLEROSIS: RISK FACTORS, DIAGNOSIS, AND TREATMENT　p. 127-131　2002　Research paper (international conference proceedings)

Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency

Y Nishida, K Hirano, K Tsukamoto, M Nagano, C Ikegami, K Roomp, M Ishihara, N Sakane, ZY Zhang, K Tsujii, A Matsuyama, T Ohama, F Matsuura, M Ishigami, N Sakai, H Hiraoka, H Hattori, C Wellington, Y Yoshida, S Misugi, MR Hayden, T Egashira, S Yamashita, Y Matsuzawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 290　No. 2　p. 713-721　2002/01　Research paper (scientific journal)

Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport

ZY Zhang, S Yamashita, K Hirano, Y Nakagawa-Toyama, A Matsuyama, M Nishida, N Sakai, M Fukasawa, H Arai, J Miyagawa, Y Matsuzawa

ATHEROSCLEROSIS　Vol. 159　No. 1　p. 67-75　2001/11　Research paper (scientific journal)

ATP-Binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP

K Tsukamoto, K Hirano, K Tsujii, C Ikegami, Z Zhongyan, Y Nishida, T Ohama, F Matsuura, S Yamashita, Y Matsuzawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 287　No. 3　p. 757-765　2001/09　Research paper (scientific journal)

CD36 deficiency and insulin resistance - Reply

K Hirano, T Kuwasako, H Kashiwagi, S Yamashita, Y Matsuzawa

LANCET　Vol. 358　No. 9277　p. 244-244　2001/07　Research paper (scientific journal)

Point mutation (-69 G -> A) in the promoter region of cholesteryl ester transfer protein gene in Japanese hyperalphalipoproteinemic subjects

M Nagano, S Yamashita, K Hirano, T Kujiraoka, M Ito, Y Sagehashi, H Hattori, N Nakajima, T Maruyama, N Sakai, T Egashira, Y Matsuzawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 21　No. 6　p. 985-990　2001/06　Research paper (scientific journal)

Localization of CD36 and scavenger receptor class A in human coronary arteries - a possible difference in the contribution of both receptors to plaque formation

Y Nakagawa-Toyama, S Yamashita, J Miyagawa, M Nishida, S Nozaki, H Nagaretani, N Sakai, H Hiraoka, K Yamamori, T Yamane, K Hirano, Y Matsuzawa

ATHEROSCLEROSIS　Vol. 156　No. 2　p. 297-305　2001/06　Research paper (scientific journal)

臨床例より見い出した黄色腫発症の分子機構

松浦 文彦, 平野 賢一, 松山 晃文, 石神 眞人, 酒井 尚彦, 平岡 久豊, 山下 静也, 松澤 佑次

動脈硬化　Vol. 29　No. Suppl.　p. 250-250　2001/05

Tangier病と異なる病態を呈した顕著な低HDL血症の1症例

松山 晃文, 酒井 尚彦, 松浦 文彦, 平野 賢一, 石神 眞人, 平岡 久豊, 山下 静也, 三杉 進, 松澤 佑次

動脈硬化　Vol. 29　No. Suppl.　p. 292-292　2001/05

Reduced adhesion of monocyte-derived macrophages from CD36-deficient patients to type I collagen

M Janabi, S Yamashita, K Hirano, K Matsumoto, N Sakai, H Hiraoka, H Kashiwagi, Y Tomiyama, S Nozaki, Y Matsuzawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 283　No. 1　p. 26-30　2001/04　Research paper (scientific journal)

CD36 deficiency associated with insulin resistance

K Miyaoka, T Kuwasako, K Hirano, S Nozaki, S Yamashita, Y Matsuzawa

LANCET　Vol. 357　No. 9257　p. 686-687　2001/03　Research paper (scientific journal)

Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein

S Yamashita, K Hirano, N Sakai, Y Matsuzawa

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　Vol. 1529　No. 1-3　p. 257-275　2000/12　Research paper (scientific journal)

タンジール病患者解析より発見したコレステロール引き抜きの分子機構 低分子量G蛋白,Cdc42のCEにおける役割

平野 賢一, 松浦 文彦, 塚本 幸資, 松山 晃文, 酒井 尚彦, 高石 健司, 山下 静也, 松澤 佑次

日本臨床分子医学会記録　Vol. 37　p. 45-45　2000/11

Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease - the small G protein may play a role in cholesterol efflux

K Hirano, F Matsuura, K Tsukamoto, ZY Zhang, A Matsuyama, K Takaishi, R Komuro, T Suehiro, S Yamashita, Y Takai, Y Matsuzawa

FEBS LETTERS　Vol. 484　No. 3　p. 275-279　2000/11　Research paper (scientific journal)

Escherichia coli sepsis increases hepatic apolipoprotein B secretion by inhibiting degradation

Hope W. Phetteplace, Natalia Sedkova, Ken-Ichi Hirano, Nicholas O. Davidson, Susan P. Lanza-Jacoby

Lipids　Vol. 35　No. 10　p. 1079-1086　2000/10　Research paper (scientific journal)

Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects

PN Duchateau, Movsesyan, I, S Yamashita, N Sakai, K Hirano, SA Schoenhaus, PM O'Connor-Kearns, SJ Spencer, RB Jaffe, RF Redberg, BY Ishida, Y Matsuzawa, JP Kane, MJ Malloy

JOURNAL OF LIPID RESEARCH　Vol. 41　No. 8　p. 1231-1236　2000/08　Research paper (scientific journal)

Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients

M Janabi, S Yamashita, K Hirano, N Sakai, H Hiraoka, K Matsumoto, ZY Zhang, S Nozaki, Y Matsuzawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 20　No. 8　p. 1953-1960　2000/08　Research paper (scientific journal)

Identification of a GPI-anchored type HDL-binding protein on human macrophages

Akifumi Matsuyama, Shizuya Yamashita, Naohiko Sakai, Takao Maruyama, Eiko Okuda, Ken-Ichi Hirano, Shinji Kihara, Hisatoyo Hiraoka, Yuji Matsuzawa

Biochemical and Biophysical Research Communications　Vol. 272　No. 3　p. 864-871　2000/06/16　Research paper (scientific journal)

Tangier disease with continuous massive and longitudinal diffuse calcification in the coronary arteries: Demonstration by the sagittal images of intravascular ultrasonography

Ryutaro Komuro, Shizuya Yamashita, Satoru Sumitsuji, Ken-Ichi Hirano, Takao Maruyama, Makoto Nishida, Fumihiko Matsuura, Akifumi Matsuyama, Taizo Sugimoto, Noriyuki Ouchi, Naohiko Sakai, Tadashi Nakamura, Toru Funahashi, Yuji Matsuzawa

Circulation　Vol. 101　No. 20　p. 2446-2448　2000/05/23　Research paper (scientific journal)

高齢者細胞にみられるCholesterol Efflux(CE)の低下と低分子量G蛋白,Cdc42との関連

塚本 幸資, 平野 賢一, 松浦 文彦, Zhang Zhongyan, 松山 晃文, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　Vol. 28　No. Suppl.　p. 159-159　2000/05

タンジール病(TD)患者解析より発見した高比重リポ蛋白(HDL)によるコレステロール引き抜き(Cholesterol Efflux,CE)の分子機構

平野 賢一, 塚本 幸資, 松浦 文彦, Zhang Zhongyan, 松山 晃文, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　Vol. 28　No. Suppl.　p. 158-158　2000/05

Cholesterol effluxエンハンサー分子の発見 ヒト単球由来マクロファージよりのScavenger Receptor Class B Type I(SR-BI)の新規変異体,SR-BIIIのクローニングとその機能解析

平野 賢一, 塚本 幸資, 松山 晃文, Zhongyan Zhang, 中川 裕美子, 池上 千秋, 獅子王 信江, 山下 静也, 松澤 佑次

動脈硬化　Vol. 28　No. Suppl.　p. 171-171　2000/05

Expression of Macrophage (Mφ) Scavenger Receptor, CD36, in Cultured Human Aortic Smooth Muscle Cells in Association With Expression of Peroxisome Proliferator Activated Receptor-γ, Which Regulates Gain of Mφ-Like Phenotype In Vitro, and Its Implication in Atherogenesis

Kengo Matsumoto, Ken-ichi Hirano, Shuichi Nozaki, Akiko Takamoto, Makoto Nishida, Yumiko Nakagawa-Toyama, Mohamed Yakub Janabi, Takeshi Ohya, Shizuya Yamashita, Yuji Matsuzawa

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 20　No. 4　p. 1027-1032　2000/04　Research paper (scientific journal)

Impairment of reverse cholesterol transport system and atherosclerosis

S Yamashita, T Maruyama, K Hirano, N Sakai, N Nakajima, Y Matsuzawa

LIPOPROTEIN METABOLISM AND ATHEROGENESIS　p. 116-123　2000　Research paper (international conference proceedings)

Expression of CD36 in cultured human aortic smooth muscle cells (HASMCs)

K Matsumoto, K Hirano, S Nozaki, M Nishida, T Ohya, MJ Yakub, T Funahashi, S Yamashita, Y Matsuzawa

LIPOPROTEIN METABOLISM AND ATHEROGENESIS　p. 272-274　2000　Research paper (international conference proceedings)

ヒト単球由来マクロファージ(Mφ)よりのCholesterol Efflux関連遺伝子のクローニング

平野 賢一, 松山 晃文, 松浦 文彦, 塚本 幸資, 池上 千秋, 細野 千穂, 酒井 尚彦, 山下 静也, 松澤 佑次, 高石 健司

動脈硬化　Vol. 27　No. Suppl.1　p. 141-141　1999/11

ヒトMφにおけるGPI-anchor型HDL結合蛋白の精製

松山 晃文, 酒井 尚彦, 丸山 貴生, 平野 賢一, 山下 静也, 松沢 佑次

動脈硬化　Vol. 27　No. Suppl.1　p. 142-142　1999/11

プロブコールによるSR-BI(Scavenger receptor class B type I)の発現増強 in vivo(ウサギ)及びin vitro(Hep G2)における検討

辻井 健一, 平野 賢一, 松浦 文彦, 細野 千穂, 池上 千秋, 中川 裕美子, 松山 晃文, 山下 静也, 松沢 佑次

動脈硬化　Vol. 27　No. Suppl.1　p. 143-143　1999/11

症例解析より見出した低分子量G蛋白(CDC42)の新しい機能 Tangier病皮膚線維芽細胞におけるAU rich elementを有したmRNAの安定性の低下とCDC42との関連性についての検討

松浦 文彦, 平野 賢一, 小室 竜太郎, 松山 晃文, 高石 健司, 山下 静也, 高井 義美, 松沢 佑次

動脈硬化　Vol. 27　No. Suppl.1　p. 141-141　1999/11

胆汁酸のHDL代謝に与える影響 原発性胆汁性肝硬変症(PBC)に見られる高HDL血症とそのメカニズムについての考察

西田 義治, 平野 賢一, 松山 晃文, 池上 千秋, 中川 裕美子, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　Vol. 27　No. Suppl.1　p. 114-114　1999/11

ヒト単球由来マクロファージにおけるLIMP-II(Lysosomal Integral Membrane Protein II)の発現調節

塚本 幸資, 平野 賢一, 松山 晃文, 山下 静也, 松澤 佑次

動脈硬化　Vol. 27　No. Suppl.1　p. 143-143　1999/11

Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions

K Hirano, S Yamashita, Y Nakagawa, T Ohya, F Matsuura, K Tsukamoto, Y Okamoto, A Matsuyama, K Matsumoto, J Miyagawa, Y Matsuzawa

CIRCULATION RESEARCH　Vol. 85　No. 1　p. 108-116　1999/07　Research paper (scientific journal)

ヒトMφにおけるHDL3結合蛋白はGPI結合型蛋白であり,caveolaeに集積する

松山 晃文, 酒井 尚彦, 西田 誠, 丸山 貴生, 平野 賢一, 宮川 潤一郎, 山下 静也, 松澤 佑次

動脈硬化　Vol. 26　No. 8　p. 98-98　1999/05

HDL受容体,SR-BIのコレステロール逆転送系における意義

平野 賢一, 中川 裕美子, 辻井 健一, 松浦 文彦, 杉本 泰造, 塚本 幸資, 松山 晃文, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　Vol. 26　No. 8　p. 138-138　1999/05

Tangier病患者由来マクロファージにおけるintracellular HDL traffickingの検討

松山 晃文, 酒井 尚彦, 西田 誠, 丸山 貴生, 平野 賢一, 宮川 潤一郎, 山下 静也, 松澤 佑次

動脈硬化　Vol. 26　No. 8　p. 98-98　1999/05

Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia - a possible pathogenesis of necrobiotic xanthogranuloma

F Matsuura, S Yamashita, K Hirano, M Ishigami, H Hiraoka, R Tamura, T Nakagawa, M Nishida, N Sakai, T Nakamura, S Nozaki, T Funahashi, C Matsumoto, M Higashiyama, K Yoshikawa, Y Matsuzawa

ATHEROSCLEROSIS　Vol. 142　No. 2　p. 355-365　1999/02　Research paper (scientific journal)

ヒト肝臓におけるCD36/LIMPII Analogous-1(CLA-1)の発現調節 HepG2細胞を用いて

辻井 健一, 平野 賢一, 松浦 文彦, 中川 裕美子, 大屋 健, 松山 晃文, 松本 健吾, 酒井 尚彦, 山下 静也, 松澤 佑次

動脈硬化　Vol. 26　No. Suppl.1　p. 135-135　1998/11

動脈硬化防御機構における脂肪組織の役割 ヒト脂肪組織におけるCD36/LIMPII Analogous-1(CLA-1)の発現とその意義

岡本 芳久, 平野 賢一, 大屋 健, 松山 晃文, 中川 裕美子, 松浦 文彦, 塚本 幸資, 酒井 尚彦, 船橋 徹, 山下 静也

動脈硬化　Vol. 26　No. Suppl.1　p. 135-135　1998/11

ヒト単球由来マクロファージよりのCD36/LIMPII Analogous-1(CLA-1)のクローニングと分化に伴う発現誘導

平野 賢一, 山下 静也, 中川 裕美子, 大屋 健, 岡本 芳久, 松浦 文彦, 松山 晃文, 酒井 尚彦, 松澤 佑次

動脈硬化　Vol. 26　No. Suppl.1　p. 135-135　1998/11

An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer

R LEE, K HIRANO, S ANANT, D BAUNOCH, N DAVIDSON

Gastroenterology　Vol. 115　No. 5　p. 1096-1103　1998/11　Research paper (scientific journal)

A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet

Powell-Braxton L, Veniant M, Latvala RD, Hirano K, Won WB, Ross J, Dybdal N, Zlot CH, Young SG, Davidson NO

Nat Med　Vol. 4　No. 8　p. 934-938　1998/08　Research paper (scientific journal)

Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes

Mathew A. von Wronski, Ken-Ichi Hirano, Lauren M. Cagen, Henry G. Wilcox, Rajendra Raghow, Fayanne E. Thorngate, Murray Heimberg, Nicholas O. Davidson, Marshall B. Elam

Metabolism　Vol. 47　No. 7　p. 869-873　1998/07　Research paper (scientific journal)

Cholesteryl ester transfer protein deficiency: virtue or vice?

Y Matsuzawa, S Yamashita, N Sakai, K Hirano, T Maruyama

ATHEROSCLEROSIS XI　Vol. 1155　p. 135-139　1998　Research paper (international conference proceedings)

Troglitazone action is independent of adipose tissue

Burant CF, Sreenan S, Hirano K, Tai TA, Lohmiller J, Lukens J, Davidson NO, Ross S, Graves RA

J Clin Invest　Vol. 100　No. 11　p. 2900-2908　1997/12　Research paper (scientific journal)

Cloning and characterization of the rat apobec-1 gene: a comparative analysis of gene structure and promoter usage in rat and mouse.

Hirano K, Min J, Funahashi T, Davidson NO

Journal of lipid research　Vol. 38　No. 6　p. 1103-1119　1997/06/01　Research paper (scientific journal)

Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan - Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity

K Hirano, S Yamashita, N Nakajima, T Arai, T Maruyama, Y Yoshida, M Ishigami, N Sakai, K KamedaTakemura, Y Matsuzawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 17　No. 6　p. 1053-1059　1997/06　Research paper (scientific journal)

Interferon alpha induces disorder of lipid metabolism by lowering postheparin lipases and cholesteryl ester transfer protein activities in patients with chronic hepatitis C

E Shinohara, S Yamashita, S Kihara, K Hirano, M Ishigami, T Arai, S Nozaki, K KamedaTakemura, S Kawata, Y Matsuzawa

HEPATOLOGY　Vol. 25　No. 6　p. 1502-1506　1997/06　Research paper (scientific journal)

Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide.

Hirano K, Min J, Funahashi T, Baunoch DA, Davidson NO

Journal of lipid research　Vol. 38　No. 5　p. 847-859　1997/05/01　Research paper (scientific journal)

Increased serum remnant lipoproteins in patients with apolipoprotein E7 (apo E-Suita)

K Yanagi, S Yamashita, H Hiraoka, M Ishigami, S Kihara, K Hirano, N Sakai, S Nozaki, T Funahashi, K KamedaTakemura, M Kubo, K Tokunaga, Y Matsuzawa

ATHEROSCLEROSIS　Vol. 131　No. 1　p. 49-58　1997/05　Research paper (scientific journal)

High-density lipoproteins from probucol-treated patients have increased capacity to promote cholesterol efflux from mouse peritoneal macrophages loaded with acetylated low-density lipoproteins

Ishigami M, Yamashita S, Sakai N, Hirano K, Arai T, Maruyama T, Takami S, Koyama M, Kameda-Takemura K, Matsuzawa Y

Eur J Clin Invest　Vol. 27　No. 4　p. 285-292　1997/04　Research paper (scientific journal)

Molecular genetics of plasma cholesteryl ester transfer protein

Shizuya Yamashita, Naohiko Sakai, Ken-Ichi Hirano, Takeshi Arai, Masato Ishigami, Takao Maruyama, Yuji Matsuzawa

Current Opinion in Lipidology　Vol. 8　No. 2　p. 101-110　1997/04　Research paper (scientific journal)

A novel nonsense mutation (G181X) in the human cholesteryl ester transfer protein gene in Japanese hyperalphalipoproteinemic subjects

Takeshi Arai, Shizuya Yamashita, Naohiko Sakai, Ken-Ichi Hirano, Sugako Okada, Masato Ishigami, Takao Maruyama, Mitsukazu Yamane, Hitoshi Kobayashi, Shuichi Nozaki, Tohru Funahashi, Kaoru Kameda-Takemura, Norimichi Nakajima, Yuji Matsuzawa

Journal of Lipid Research　Vol. 37　No. 10　p. 2145-2154　1996/10　Research paper (scientific journal)

Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48

Hirano K, Young SG, Farese RV, Jr, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO

J. Biol. Chem.　Vol. 271　No. 17　p. 9887-9890　1996/04　Research paper (scientific journal)

ATHEROSCLEROTIC DISEASE IN MARKED HYPERALPHALIPOPROTEINEMIA - COMBINED REDUCTION OF CHOLESTERYL ESTER TRANSFER PROTEIN AND HEPATIC TRIGLYCERIDE LIPASE

K HIRANO, S YAMASHITA, Y KUGA, N SAKAI, S NOZAKI, S KIHARA, T ARAI, K YANAGI, S TAKAMI, M MENJU, M ISHIGAMI, Y YOSHIDA, K KAMEDATAKEMURA, K HAYASHI, Y MATSUZAWA

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 15　No. 11　p. 1849-1856　1995/11　Research paper (scientific journal)

Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency

Sakai N, Yamashita S, Hirano K, Ishigami M, Arai T, Kobayashi K, Funahashi T, Matsuzawa Y

Eur J Clin Invest　Vol. 25　No. 5　p. 332-339　1995/05　Research paper (scientific journal)

FREQUENCY OF EXON-15 MISSENSE MUTATION (442D-G) IN CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN HYPERALPHALIPOPROTEINEMIC JAPANESE SUBJECTS

N SAKAI, S YAMASHITA, K HIRANO, M MENJU, T ARAI, K KOBAYASHI, M ISHIGAMI, Y YOSHIDA, T HOSHINO, N NAKAJIMA, K KAMEDATAKEMURA, Y MATSUZAWA

ATHEROSCLEROSIS　Vol. 114　No. 2　p. 139-145　1995/04　Research paper (scientific journal)

Very high density lipoproteins induced by plasma cholesteryl ester transfer protein (CETP) have a potent antiatherogenic function

Yamashita S, Ishigami M, Arai T, Sakai N, Hirano K, Kameda-Takemura K, Tokunaga K, Matsuzawa Y

Ann N Y Acad Sci　Vol. 748　p. 606-608　1995/01　Research paper (scientific journal)

CHOLESTEROL ESTER TRANSFER PROTEIN AND CARDIOVASCULAR DISEASE

Y MATSUZAWA, S YAMASHITA, N SAKAI, K HIRANO, M ISHIGAMI

ATHEROSCLEROSIS X　Vol. 1066　p. 736-742　1995　Research paper (international conference proceedings)

Molecular defect and atherogenicity in cholesteryl ester transfer protein deficiency

K. I. Hirano, S. Yamashita, N. Sakai, T. Arai, Y. Yoshida, S. Nozaki, K. Kameda-Takemura, Y. Matsuzawa

Annals of the New York Academy of Sciences　Vol. 748　p. 599-602　1995/01　Research paper (international conference proceedings)

LARGE AND CHOLESTERYL ESTER-RICH HIGH-DENSITY-LIPOPROTEINS IN CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) DEFICIENCY CAN NOT PROTECT MACROPHAGES FROM CHOLESTEROL ACCUMULATION INDUCED BY ACETYLATED LOW-DENSITY LIPOPROTEINS

M ISHIGAMI, S YAMASHITA, N SAKAI, T ARAI, K HIRANO, H HIRAOKA, K KAMEDATAKEMURA, Y MATSUZAWA

JOURNAL OF BIOCHEMISTRY　Vol. 116　No. 2　p. 257-262　1994/08　Research paper (scientific journal)

Increased plasma cholesteryl ester transfer protein in obese subjects. A possible mechanism for the reduction of serum HDL cholesterol levels in obesity

Arai T, Yamashita S, Hirano K, Sakai N, Kotani K, Fujioka S, Nozaki S, Keno Y, Yamane M, Shinohara E

Arterioscler Thromb　Vol. 14　No. 7　p. 1129-1136　1994/07　Research paper (scientific journal)

OPENING ADDRESS OF THE YEAR

HIRANO Kenichi

Journal of Japan Institute of Light Metals　Vol. 44　No. 1　p. 1-2　1994

A MISSENSE MUTATION IN THE CHOLESTERYL ESTER TRANSFER PROTEIN GENE WITH POSSIBLE DOMINANT EFFECTS ON PLASMA HIGH-DENSITY-LIPOPROTEINS

K TAKAHASHI, XC JIANG, N SAKAI, S YAMASHITA, K HIRANO, H BUJO, H YAMAZAKI, J KUSUNOKI, T MIURA, P KUSSIE, Y MATSUZAWA, Y SAITO, A TALL

JOURNAL OF CLINICAL INVESTIGATION　Vol. 92　No. 4　p. 2060-2064　1993/10　Research paper (scientific journal)

DECREASE OF HEPATIC TRIGLYCERIDE LIPASE LEVELS AND INCREASE OF CHOLESTERYL ESTER TRANSFER PROTEIN-LEVELS IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS - RELATIONSHIP TO ABNORMALITIES IN HIGH-DENSITY-LIPOPROTEIN

H HIRAOKA, S YAMASHITA, Y MATSUZAWA, M KUBO, S NOZAKI, N SAKAI, K HIRANO, S KAWATA, S TARUI

HEPATOLOGY　Vol. 18　No. 1　p. 103-110　1993/07　Research paper (scientific journal)

FREQUENCY OF INTRON-14 SPLICING DEFECT OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE IN THE JAPANESE GENERAL-POPULATION - RELATION BETWEEN THE MUTATION AND HYPERALPHALIPOPROTEINEMIA

K HIRANO, S YAMASHITA, T FUNAHASHI, N SAKAI, M MENJU, M ISHIGAMI, H HIRAOKA, K KAMEDATAKEMURA, K TOKUNAGA, T HOSHINO, K KUMASAKA, K KAWANO, Y MATSUZAWA

ATHEROSCLEROSIS　Vol. 100　No. 1　p. 85-90　1993/04　Research paper (scientific journal)

POLYDISPERSE LOW-DENSITY LIPOPROTEINS IN HYPERALPHALIPOPROTEINEMIC CHRONIC ALCOHOL DRINKERS IN ASSOCIATION WITH MARKED REDUCTION OF CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITY

K HIRANO, Y MATSUZAWA, N SAKAI, H HIRAOKA, S NOZAKI, T FUNAHASHI, S YAMASHITA, M KUBO, S TARUI

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 41　No. 12　p. 1313-1318　1992/12　Research paper (scientific journal)

Low-density lipoproteins in hyperalphalipoproteinemic heavy alcohol drinkers have reduced affinity for the low-density lipoprotein receptor

Ken-ichi Hirano, Shizuya Yamashita, Naohiko Sakai, Hisatoyo Hiraoka, Yuhya Ueyama, Tohru Funahashi, Yuji Matsuzawa

Clinical Biochemistry　Vol. 25　No. 5　p. 357-362　1992/10　Research paper (scientific journal)

EFFECTS OF PURIFIED EICOSAPENTAENOIC ACID ETHYL-ESTER ON PLASMA-LIPOPROTEINS IN PRIMARY HYPERCHOLESTEROLEMIA

S NOZAKI, Y MATSUZAWA, K HIRANO, N SAKAI, M KUBO, S TARUI

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH　Vol. 62　No. 3　p. 256-260　1992　Research paper (scientific journal)

Detection of two species of low density lipoprotein particles in cholesteryl ester transfer protein deficiency

Naohiko Sakai, Yuji Matsuzawa, Ken-Ichi Hirano, Shizuya Yamashita, Shuichi Nozaki, Yuhya Ueyama, Masaharu Kubo, Seiichiro Tarui

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 11　No. 1　p. 71-79　1991/02　Research paper (scientific journal)

Studies on the two families of hyperalphalipoproteinemia caused by complete deficiency of cholesteryl ester transfer activity - Existence of small polydisperse LDL and markedly large HDL

S. Yamashita, Y. Ueyama, S. Kihara, T. Kawamoto, T. Nakamura, M. Kubo, Y. Matsuzawa, S. Tarui, H. Kako, G. Mizuno, T. Yasugi, H. Akioka, K. Hirano, M. Okazaki

Journal of Japan Atherosclerosis Society　Vol. 17　No. 2　p. 371-379　1989　Research paper (scientific journal)

Thermal expansion of solids.

Hirano Ken-ichi

Netsu Sokutei　Vol. 15　No. 1　p. 10-18　1988

Professor M. Cohen-Laureate for The 1987 Kyoto Prize

Hirano Kenichi

Materia Japan　Vol. 27　No. 1　p. 41-50　1988