京都大学大学院 生命科学研究科 統合生命科学専攻 遺伝子動態学分野 博士課程
2010/04 - 2013/03
京都大学大学院 生命科学研究科 統合生命科学専攻 遺伝子動態学分野 修士課程
2008/04 - 2010/03
Kyoto University
2004/04 - 2008/03
Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects.
Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Saito, Kana Inoue, Yumiko Hamano, Yuichiro Doki, Hidetoshi Eguchi, Satoshi Obika, Hideshi Ishii
Molecular therapy. Nucleic acids Vol. 36 No. 2 p. 102548-102548 2025/06/10 Research paper (scientific journal)
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer.
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii
Cancer medicine Vol. 14 No. 11 2025/06 Research paper (scientific journal)
In Vivo Engineered CAR-T Cell Therapy: Lessons Built from COVID-19 mRNA Vaccines.
Sikun Meng, Tomoaki Hara, Yutaka Miura, Yasuko Arao, Yoshiko Saito, Kana Inoue, Takaaki Hirotsu, Andrea Vecchione, Taroh Satoh, Hideshi Ishii
International journal of molecular sciences Vol. 26 No. 7 2025/03/28 Research paper (scientific journal)
Recent Exploration of Solid Cancer Biomarkers Hidden Within Urine or Blood Exosomes That Provide Fundamental Information for Future Cancer Diagnostics.
Tomoaki Hara, Sikun Meng, Aya Hasan Alshammari, Hideyuki Hatakeyama, Yasuko Arao, Yoshiko Saito, Kana Inoue, Eric di Luccio, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii
Diagnostics (Basel, Switzerland) Vol. 15 No. 5 2025/03/05 Research paper (scientific journal)
Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine.
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Aya Hasan Alshammari, Hideyuki Hatakeyama, Eric di Luccio, Andrea Vecchione, Takaaki Hirotsu, Hideshi Ishii
Biomedicines Vol. 13 No. 1 2025/01/06 Research paper (scientific journal)
Recent advances in noncoding RNA modifications of gastrointestinal cancer.
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Yuichiro Doki, Hidetoshi Eguchi, Toru Kitagawa, Hideshi Ishii
Cancer science 2024/11/01 Research paper (scientific journal)
Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T-cell therapy in solid tumors.
Sikun Meng, Tomoaki Hara, Yutaka Miura, Hideshi Ishii
Cancer science 2024/08/21 Research paper (scientific journal)
がん特異的常在性メモリーT細胞の性状解析
孟 思昆, 北風 雅敏, 原 知明, 石井 秀始
臨床免疫・アレルギー科 Vol. 82 No. 1 p. 14-19 2024/07
Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
Hiromichi Sato, Sikun Meng, Kazuki Sasaki, Shogo Kobayashi, Kansuke Kido, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Daisuke Motooka, Shizuka Uchida, Ken Ofusa, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi, Tomoaki Hara, Hideshi Ishii
International journal of oncology Vol. 65 No. 1 2024/07 Research paper (scientific journal)
Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications.
Hiromichi Sato, Sikun Meng, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Kazuki Sasaki, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
Biomedicines Vol. 12 No. 6 2024/06/17 Research paper (scientific journal)
Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease.
Tomoaki Hara, Sikun Meng, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Tsuji, Takeshi Yabumoto, Yuichiro Doki, Hidetoshi Eguchi, Shizuka Uchida, Hideshi Ishii
Cancer science 2024/04/28 Research paper (scientific journal)
High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker.
Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Kazuki Sasaki, Yu Takeda, Yoshiko Tsuji, Yasuko Arao, Ken Ofusa, Toru Kitagawa, Daisaku Yamada, Hidenori Takahashi, Shogo Kobayashi, Daisuke Motooka, Yutaka Suzuki, Sarah Rennie, Shizuka Uchida, Masaki Mori, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
Cancer science 2024/04/24 Research paper (scientific journal)
RN7SL1 may be translated under oncogenic conditions.
Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Hiromichi Sato, Daisuke Motooka, Shizuka Uchida, Hideshi Ishii
Proceedings of the National Academy of Sciences of the United States of America Vol. 121 No. 12 2024/03/19 Research paper (scientific journal)
Revealing neuropilin expression patterns in pancreatic cancer: From single‑cell to therapeutic opportunities (Review).
Sikun Meng, Tomoaki Hara, Hiromichi Sato, Shotaro Tatekawa, Yoshiko Tsuji, Yoshiko Saito, Yumiko Hamano, Yasuko Arao, Noriko Gotoh, Kazuhiko Ogawa, Hideshi Ishii
Oncology letters Vol. 27 No. 3 p. 113-113 2024/03 Research paper (scientific journal)
<scp>RNA</scp> methylation in inflammatory bowel disease
Yuki Ozato, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Mamoru Uemura, Takeshi Yabumoto, Shizuka Uchida, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
Cancer Science 2024/01/23 Research paper (scientific journal)
Publisher: Wiley
[Future Perspectives of Single-Cell RNA Sequencing in Cancer Research].
Sikun Meng, Tomoaki Hara, Hideshi Ishii
Gan to kagaku ryoho. Cancer & chemotherapy Vol. 51 No. 1 p. 14-23 2024/01 Research paper (scientific journal)
Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions.
Hiromichi Sato, Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Yoshiko Saito, Kazuki Sasaki, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
Cancer science Vol. 114 No. 9 p. 3487-3495 2023/09 Research paper (scientific journal)
Drug Discovery and Development of miRNA-Based Nucleotide Drugs for Gastrointestinal Cancer.
Hiromichi Sato, Tomoaki Hara, Sikun Meng, Yoshiko Tsuji, Yasuko Arao, Kazuki Sasaki, Norikatsu Miyoshi, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
Biomedicines Vol. 11 No. 8 2023/08/09 Research paper (scientific journal)
Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review).
Yoshiko Tsuji, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Yasuko Arao, Ken Ofusa, Hideshi Ishii
Oncology letters Vol. 26 No. 2 p. 336-336 2023/08 Research paper (scientific journal)
線維芽細胞の老化の指標となるニコチンアミドに関する研究
千々松 良太, 孟 思こん, 原 知明, 石井 秀始
代謝異常治療研究基金研究業績集 Vol. 46 p. 41-49 2023
Publisher: (一財)代謝異常治療研究基金Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Ken Ofusa, Tsunekazu Mizushima, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii
British Journal of Cancer 2023 Research paper (scientific journal)
Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic.
Rabab A Husseini, Naoko Abe, Tomoaki Hara, Hiroshi Abe, Kentaro Kogure
Biological & pharmaceutical bulletin Vol. 46 No. 2 p. 301-308 2023 Research paper (scientific journal)
Pancreatic Cancer Research beyond DNA Mutations.
Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Mirei Ogita, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Shizuka Uchida, Hideshi Ishii
Biomolecules Vol. 12 No. 10 2022/10/17 Research paper (scientific journal)
Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment.
Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Shogo Kobayashi, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Hideshi Ishii
Frontiers in oncology Vol. 12 p. 1018333-1018333 2022 Research paper (scientific journal)
Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma.
Hiromichi Sato, Tomoaki Hara, Shotaro Tatekawa, Kazuki Sasaki, Shogo Kobayashi, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, Kazuhiko Ogawa, Shizuka Uchida, Hideshi Ishii
Frontiers in physiology Vol. 13 p. 1025923-1025923 2022 Research paper (scientific journal)
Directed evolution of a synthetic RNA-protein module to create a new translational switch.
Tomoaki Hara, Hirohide Saito, Tan Inoue
Chemical communications (Cambridge, England) Vol. 49 No. 37 p. 3833-5 2013/05/10 Research paper (scientific journal)
Light-regulated mRNA condensation by a photosensitive surfactant works as a series photoswitch of translation activity in the presence of small RNAs.
Sergii Rudiuk, Hirohide Saito, Tomoaki Hara, Tan Inoue, Kenichi Yoshikawa, Damien Baigl
Biomacromolecules Vol. 12 No. 11 p. 3945-51 2011/11/14 Research paper (scientific journal)
Synthetic translational regulation by an L7Ae-kink-turn RNP switch.
Hirohide Saito, Tetsuhiro Kobayashi, Tomoaki Hara, Yoshihiko Fujita, Karin Hayashi, Rie Furushima, Tan Inoue
Nature chemical biology Vol. 6 No. 1 p. 71-8 2010/01 Research paper (scientific journal)
Sequence-independent and reversible photocontrol of transcription/expression systems using a photosensitive nucleic acid binder.
André Estévez-Torres, Cécile Crozatier, Antoine Diguet, Tomoaki Hara, Hirohide Saito, Kenichi Yoshikawa, Damien Baigl
Proceedings of the National Academy of Sciences of the United States of America Vol. 106 No. 30 p. 12219-23 2009/07/28 Research paper (scientific journal)
m6A修飾RNA制御機構とがん幹細胞
原 知明, 孟 思昆, 石井 秀始
実験医学（増刊号）がん幹細胞とは何者なのか？ がんの「幹細胞性」を最定義する 2025/07
NNMTはがん関連線維芽細胞のマーカー遺伝子でありがん転移抑制の標的遺伝子となる
原 知明, 孟 思昆, 石井 秀始
第34回日本がん転移学会学術集会・総会 2025/06/19
栄養欠乏食は腸内NTPを減少し腸内細菌叢を変化させる
原知明、孟思昆、荒尾泰子、斉藤佳子、井上佳奈、石井秀始
第11回がんと代謝研究会 2025/05/29
Methionine, tryptophan, and niacin deficiencies promote lipolysis and proteolysis and alter gut microbiota
2024/11/06
m6A modification in pancreatic cancer tissue and application of modified mRNAs for cancer therapy
Tomoaki Hara, Sikun Meng, Hideshi Ishii
The 83rd Annual Meeting of the Japanese Cancer Association 2024/09/19
RN7SL1は発がん状況下でマイクロペプチドを生成する
原知明, 孟思昆, 辻好子, 荒尾泰子, 斉藤佳子, 石井秀始
第10回がんと代謝研究会 2024/08/02
SRP9 migrates nucleus and regulates gene expression through binding to various non-coding RNAs
Tomoaki Hara, Sikun Meng, Hiromichi Sato, Kazuki Sasaki, Yasuko Arao, Yoshiko Saito, Ken Ofusa, Daisuke Motooka, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii
2024/06/27
DSS飲水IBD疾患モデルマウスにおいて、アミノ酸欠乏は 脂肪およびタンパク質分解を促進し、腸内細菌叢の変化をもたらす
原 知明、孟思昆、石井秀始
第20回日本消化管学会総会学術集会 2024/02/09
RN7SL1, an ncRNA that constitutes a signal recognition particle, is translated under oncogenic conditions to produce a micropeptide?
Tomoaki Hara, Sikun Meng, Hideshi Ishii
2023/12/08
RN7SL1, an ncRNA that constitutes a signal recognition particle, is translated under oncogenic conditions to produce a micropeptide?
Tomoaki Hara, Sikun Meng, Hideshi Ishii
2023/12/07
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer
Hara Tomoaki, Meng Sikun, Arao Yasuko, Saito Yoshiko, Inoue Kana, Rennie Sarah, Ofusa Ken, Kitagawa Toru, Ishii Hideshi
Cancer Medicine Vol. 14 No. 11 2025/03/25
Recent advances in noncoding RNA modifications of gastrointestinal cancer
Hara Tomoaki, Meng Sikun, Arao Yasuko, Saito Yoshiko, Inoue Kana, Rennie Sarah, Ofusa Ken, Doki Yuichiro, Eguchi Hidetoshi, Kitagawa Toru, Ishii Hideshi
Cancer Science Vol. 116 No. 1 p. 8-20 2024/11/01
Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality
Sato Hiromichi, Meng Sikun, Sasaki Kazuki, Kobayashi Shogo, Kido Kansuke, Tsuji Yoshiko, Arao Yasuko, Saito Yoshiko, Iwagami Yoshifumi, Yamada Daisaku, Tomimaru Yoshito, Noda Takehiro, Takahashi Hidenori, Motooka Daisuke, Uchida Shizuka, Ofusa Ken, Satoh Taroh, Doki Yuichiro, Eguchi Hidetoshi, Hara Tomoaki, Ishii Hideshi
International Journal of Oncology Vol. 65 No. 1 2024/07/01
RN7SL1 may be translated under oncogenic conditions
Hara Tomoaki, Meng Sikun, Tsuji Yoshiko, Arao Yasuko, Saito Yoshiko, Sato Hiromichi, Motooka Daisuke, Uchida Shizuka, Ishii Hideshi
Proceedings of the National Academy of Sciences of the United States of America Vol. 121 No. 12 2024/03/19
