Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution.

Harald Gröger, Satoshi Horino, Kyohei Kanomata, Shuji Akai

Chemistry (Weinheim an der Bergstrasse, Germany)　2024/04/05　Research paper (scientific journal)

Furanyl bis(indolyl)methane as a palladium ion-selective chromogenic agent.

Kazuho Ban, Shiho Nozaki, Takaaki Aijima, Shuki Oyama, Hirofumi Tsujino, Yusuke Kanematsu, Shuji Akai, Yoshinari Sawama

Organic & biomolecular chemistry　Vol. 22　No. 14　p. 2734-2738　2024/04/03　Research paper (scientific journal)

Light-controllable cell-membrane disturbance for intracellular delivery.

Wenting Huo, Koji Miki, Huiying Mu, Takashi Osawa, Harumi Yamaguma, Yuuya Kasahara, Satoshi Obika, Yoshimasa Kawaguchi, Hisaaki Hirose, Shiroh Futaki, Yusuke Miyazaki, Wataru Shinoda, Shuji Akai, Kouichi Ohe

Journal of materials chemistry. B　2024/03/08　Research paper (scientific journal)

Oxidative Coupling of Hydroquinone Derivatives with Olefins to Dihydrobenzofurans.

Yoshinari Sawama, Keiichiro Nakajima, Takaaki Aijima, Miyu Mae, Shinsuke Komagawa, Hiroki Nakata, Hironao Sajiki, Shuji Akai

Chemical & pharmaceutical bulletin　Vol. 72　No. 6　p. 566-569　2024　Research paper (scientific journal)

Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst.

Rei Ikeda, Tomoya Nishio, Kyohei Kanomata, Shuji Akai

Chemical & pharmaceutical bulletin　Vol. 72　No. 2　p. 213-219　2024　Research paper (scientific journal)

First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls

Moeka Ishida, Rina Adachi, Kazuki Kobayashi, Yukiko Yamamoto, Chinatsu Kawahara, Tsuyoshi Yamada, Hiroshi Aoyama, Kyohei Kanomata, Shuji Akai, Patrick Y. S. Lam, Hironao Sajiki, Takashi Ikawa

Chemical Communications　2024　Research paper (scientific journal)

Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen.

Hiromasa Uchiyama, Kazuho Ban, Shiho Nozaki, Yui Ikeda, Takayoshi Ishimoto, Hiroyoshi Fujioka, Mako Kamiya, Ryugo Amari, Hirofumi Tsujino, Masayoshi Arai, Sachi Yamazoe, Keiko Maekawa, Takuma Kato, Mitsunobu Doi, Kazunori Kadota, Yuichi Tozuka, Naohito Tomita, Hironao Sajiki, Shuji Akai, Yoshinari Sawama

RSC medicinal chemistry　Vol. 14　No. 12　p. 2583-2592　2023/12/13　Research paper (scientific journal)

Construction of Functionalized ortho‐Naphthoquinone Methides via Site‐Selective Ring Opening of 1‐Siloxy‐1,4‐epoxy‐1,4‐dihydronaphthalenes

Takaaki Aijima, Shinsuke Komagawa, Shuji Akai, Yoshinari Sawama

Advanced Synthesis & Catalysis　Vol. 365　No. 22　p. 3981-3986　2023/10/12　Research paper (scientific journal)

Oxidative Functionalization of Catechol Derivatives Substituted with Electron-Withdrawing Groups

Yoshinari Sawama, Hyoga Shimizu, Takaaki Aijima, Taro Udagawa, Shoko Kuwata, Tsuyoshi Yamada, Hironao Sajiki, Shuji Akai

Chemical and Pharmaceutical Bulletin　Vol. 71　No. 10　p. 782-786　2023/10/01　Research paper (scientific journal)

Lipase/H2SO4‐Cocatalyzed Dynamic Kinetic Resolution of Alcohols in Pickering Emulsion

Jihoon Moon, Takusho Kin, Karin Mizuno, Shuji Akai, Kyohei Kanomata

ChemCatChem　2023/09/22　Research paper (scientific journal)

Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Groups in Drug Discovery

Kazuho Ban, Keisuke Imai, Shuki Oyama, Jin Tokunaga, Yui Ikeda, Hiromasa Uchiyama, Kazunori Kadota, Yuichi Tozuka, Shuji Akai, Yoshinari Sawama

Angewandte Chemie　2023/09/19　Research paper (scientific journal)

Unprecedented Regioselective Deuterium‐Incorporation of Alkyltrimethylammonium Chlorides and Raman Analysis

Yoshinari Sawama, Takumi Matsuda, Shogo Moriyama, Kazuho Ban, Hiroyoshi Fujioka, Mako Kamiya, Jingwen Shou, Yasuyuki Ozeki, Shuji Akai, Hironao Sajiki

Asian Journal of Organic Chemistry　Vol. 12　No. 3　2023/02/03　Research paper (scientific journal)

Homemade Solution of NaOD in D ₂ O: Applications in the Field of Stilbene‐ d ₁ Synthesis

Keisuke Imai, Naohito Tomita, Hiroyoshi Fujioka, Mako Kamiya, Riku Ogasahara, Kazuho Ban, Hyoga Shimizu, Takayoshi Ishimoto, Hironao Sajiki, Shuji Akai, Yoshinari Sawama

Asian Journal of Organic Chemistry　Vol. 12　No. 3　2023/01/09　Research paper (scientific journal)

Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q

Shogo Moriyama, Miyu Mae, Daiki Shibata, Hiroyuki Yamakoshi, Shinji Kajimoto, Takakazu Nakabayashi, Takayoshi Ishimoto, Kaiki Mogi, Hironao Sajiki, Shuji Akai, Yoshinari Sawama

Chemical Communications　Vol. 59　p. 12100-12103　2023　Research paper (scientific journal)

Chemoenzymatic Dynamic Kinetic Resolution of Alcohols

K. Kanomata, S. Akai

Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)　p. 181-217　2023　Part of collection (book)

Enantiodivergent Chemoenzymatic Dynamic Kinetic Resolution: Conversion of Racemic Propargyl Alcohols into Both Enantiomers

Satoshi Horino, Tomoya Nishio, Shinji Kawanishi, Shinya Oki, Koichi Nishihara, Takashi Ikawa, Kyohei Kanomata, Karla Wagner, Harald Gröger, Shuji Akai

Chemistry – A European Journal　2022/10/07　Research paper (scientific journal)

Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki–Miyaura Coupling Conditions

Naoki Oka, Tsuyoshi Yamada, Hironao Sajiki, Shuji Akai, Takashi Ikawa

Organic Letters　Vol. 24　No. 19　p. 3510-3514　2022/05/20　Research paper (scientific journal)

Lipase-Catalyzed Kinetic Resolution of C1-Symmetric Heterocyclic Biaryls

Kengo Kasama, Yuya Hinami, Karin Mizuno, Satoshi Horino, Tomoya Nishio, Chiharu Yuki, Kyohei Kanomata, Gamal A. I. Moustafa, Harald Gröger, Shuji Akai

Chemical and Pharmaceutical Bulletin　Vol. 70　No. 5　p. 391-399　2022/05/01　Research paper (scientific journal)

μ-Oxo-Hypervalent-Iodine-Catalyzed Oxidative C-H Amination for Synthesis of Benzolactam Derivatives.

Hirotaka Sasa, Koyo Mori, Kotaro Kikushima, Yasuyuki Kita, Toshifumi Dohi

Chemical & pharmaceutical bulletin　Vol. 70　No. 2　p. 106-110　2022/02/01　Research paper (scientific journal)

Oxidative Two-way Regiocontrolled Coupling of 3-Methoxycarbonylcatechol and Indoles to Arylindoles

Yoshinari Sawama, Shoko Kuwata, Miyu Mae, Taro Udagawa, Shuji Akai, Hironao Sajiki

Chemical Communications　2022　Research paper (scientific journal)

Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method

Xin Wu, Yuhki Yokoyama, Hidekazu Takahashi, Shihori Kouda, Hiroyuki Yamamoto, Jiaqi Wang, Yoshihiro Morimoto, Kazumasa Minami, Tsuyoshi Hata, Awad Shamma, Akira Inoue, Masahisa Ohtsuka, Satoshi Shibata, Shogo Kobayashi, Shuji Akai, Hirofumi Yamamoto

Journal of Personalized Medicine　Vol. 11　No. 11　p. 1160-1160　2021/11/08　Research paper (scientific journal)

Cover Feature: Direct Nucleophilic Substitution of Alcohols Using an Immobilized Oxovanadium Catalyst (Eur. J. Org. Chem. 31/2021)

Tomoya Nishio, Shin Yoshioka, Kai Hasegawa, Kenzo Yahata, Kyohei Kanomata, Shuji Akai

European Journal of Organic Chemistry　Vol. 2021　No. 31　p. 4410-4410　2021/08/20　Research paper (scientific journal)

Direct Nucleophilic Substitution of Alcohols Using an Immobilized Oxovanadium Catalyst

Tomoya Nishio, Shin Yoshioka, Kai Hasegawa, Kenzo Yahata, Kyohei Kanomata, Shuji Akai

European Journal of Organic Chemistry　Vol. 2021　No. 31　p. 4417-4422　2021/08/20　Research paper (scientific journal)

Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes

Takashi Ikawa, Yuta Yamamoto, Akito Heguri, Yutaka Fukumoto, Tomonari Murakami, Akira Takagi, Yuto Masuda, Kenzo Yahata, Hiroshi Aoyama, Yasuteru Shigeta, Hiroaki Tokiwa, Shuji Akai

Journal of the American Chemical Society　Vol. 143　No. 29　p. 10853-10859　2021/07/28　Research paper (scientific journal)

Synthetic Studies on the Viridin Skeleton through Regio- and Stereoselective Functionalization of the AE-Ring Moiety

Shuhei Hori, Sho Ishida, Go Itoh, Koji Sugiyama, Chiharu Yuki, Masahiro Egi, Kenzo Yahata, Takashi Ikawa, Shuji Akai

SYNLETT　Vol. 32　No. 12　p. 1187-1191　2021/07　Research paper (scientific journal)

Four-Step One-Pot Catalytic Asymmetric Synthesis of Polysubstituted Tricyclic Compounds: Lipase-Catalyzed Dynamic Kinetic Resolution Followed by an Intramolecular Diels–Alder Reaction

Izuru Tsuchimochi, Shuhei Hori, Yasuo Takeuchi, Masahiro Egi, Tomo-o Satoh, Kyohei Kanomata, Takashi Ikawa, Shuji Akai

Synlett　Vol. 32　No. 08　p. 822-828　2021/05　Research paper (scientific journal)

1-Alkoxyvinyl Ester as an Excellent Acyl Donor: Efficient Macrolactone Synthesis

Yasuyuki Kita, Shuji Akai, Hiromichi Fujioka, Tohru Kamitanaka

JOURNAL OF ORGANIC CHEMISTRY　Vol. 86　No. 5　p. 3683-3696　2021/03　Research paper (scientific journal)

Continuous flow biocatalysis for the synthesis of pharmaceuticals

Shuji Akai

Chemical Engineering Japan　Vol. 85　No. 11　p. 619-622　2021

Chemo- and regioselective cross-dehydrogenative coupling reaction of 3-hydroxycarbazoles with arenols catalyzed by a mesoporous silica-supported oxovanadium

Kengo Kasama, Kyohei Kanomata, Yuya Hinami, Karin Mizuno, Yuta Uetake, Toru Amaya, Makoto Sako, Shinobu Takizawa, Hiroaki Sasai, Shuji Akai

RSC Advances　Vol. 11　No. 56　p. 35342-35350　2021　Research paper (scientific journal)

Regio-Complementary Preparation of 6- and 7-Fluoro-1,2,3,4-tetrahydroquinolines via the Cyclization of Catecholamines Followed by Deoxyfluorination

Kazuyuki Saito, Wang Zhou, Shohei Sato, Keita Takubo, Kazunori Furutsu, Ahmed A. B. Mohamed, Euis Maras Purwati, Takashi Ikawa, Shuji Akai

HETEROCYCLES　Vol. 103　No. 2　p. 902-902　2021　Research paper (scientific journal)

Continuous‐Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase–Oxovanadium Cocatalysis

Koichi Higashio, Satoko Katsuragi, Dhiman Kundu, Niklas Adebar, Carmen Plass, Franziska Kühn, Harald Gröger, Shuji Akai

Eur. J. Org. Chem.　Vol. 13　p. 1961-1967　2020/04　Research paper (scientific journal)

Cobalt-Catalyzed Hydroamination of Alkenes with 5-Substituted Tetrazoles: Facile Access to 2,5-Disubstituted Tetrazoles and Asymmetric Intermolecular Hydroaminations

Kenzo Yahata, Yuki Kaneko, Shuji Akai

Chem. Pharm. Bull.　Vol. 68　p. 332-335　2020/04　Research paper (scientific journal)

One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids

Takashi Ikawa, JingKai Sun, Akira Takagi, Shuji Akai

J. Org. Chem.　Vol. 85　p. 3383-3392　2020/02　Research paper (scientific journal)

Enantiodivergent Synthesis of Axially Chiral Biphenyls from σ‐Symmetric 1,1'‐Biphenyl‐2,6‐diol Derivatives by Single Lipase‐Catalyzed Acylative and Hydrolytic Desymmetrization

Kengo Kasama, Hiroshi Aoyama, Shuji Akai

Eur. J. Org.　Vol. 6　p. 654-661　2020/02　Research paper (scientific journal)

One-Pot Formal Dehydrogenative Ketone Synthesis from Aldehydes and Non-Activated Hydrocarbons

Kenzo Yahata, Shin Yoshioka, Shuhei Hori, Shu Sakurai, Yuki Kaneko, Kai Hasegawa, Shuji Akai

Chem. Pharm. Bull.　Vol. 68　No. 4　p. 336-338　2020　Research paper (scientific journal)

Dynamic kinetic resolution of a tertiary alcohol

Franziska Kühn, Satoko Katsuragi, Yasuhiro Oki, Cedric Scholz, Shuji Akai, Harald Gröger

Chem. Comuun.　Vol. 26　p. 2885-2888　2020/01　Research paper (scientific journal)

Coupling Reaction between Aldehydes and Non-Activated Hydrocarbons via the Reductive Radical-Polar Crossover Pathway

Kenzo Yahata, Shu Sakurai, Shuhei Hori, Shin Yoshioka, Yuki Kaneko, Kai Hasegawa, Shuji Akai

Org. Lett.　Vol. 22　p. 1199-1203　2020/01　Research paper (scientific journal)

Cobalt-Catalyzed Intermolecular Markovnikov Hydroamination of Nonactivated Olefins: N2-Selective Alkylation of Benzotriazole

Kenzo Yahata, Yuki Kaneko, Shuji Akai

Org. Lett.　Vol. 22　p. 598-603　2020/01　Research paper (scientific journal)

One‐Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols

Takashi Ikawa, Shigeaki Masuda, Shuji Akai

Chem. Eur. J.　Vol. 26　p. 4320-4332　2020/01　Research paper (scientific journal)

Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity

Hirofumi Tsujino, Tadayuki Uno, Taku Yamashita, Masafumi Katsuda, Kazuki Takada, Takeshi Saiki, Shotaro Maeda, Akira Takagi, Shigeaki Masuda, Yasuhiko Kawano, Kanji Meguro, Shuji Akai

Bioorg Med Chem Lett.　Vol. 29　No. 19　p. 126607-126607　2019/10　Research paper (scientific journal)

Efficient N-arylation of azole compounds utilizing selective aryl-transfer TMP-iodonium(III) reagent

Daichi Koseki, Erika Aoto, Toshitaka Shoji, Kazuma Watanabe, Yasuko In, Yasuyuki Kita, Toshifumi Dohi

Tetrahedron Lett　Vol. 60　No. 18　p. 1281-1286-1286　2019/05　Research paper (scientific journal)

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Noshita Megumi, Shimizu Yuhei, Morimoto Hiroyuki, Akai Shuji, Hamashima Yoshitaka, Ohneda Noriyuki, Odajima Hiromichi, Ohshima Takashi

ORGANIC PROCESS RESEARCH & DEVELOPMENT　Vol. 23　No. 4　p. 588-594　2019/04　Research paper (scientific journal)

Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of 2 Propargyl Alcohols: Competition between Racemization and Rearrangement

Shinji Kawanishi, Shinya Oki, Dhiman Kundu, Shuji Akai

Org. Lett.　Vol. 21　p. 2978-2982　2019/03　Research paper (scientific journal)

Dynamic Kinetic Resolution for Asymmetric Synthesis

Shuji Akai, Gamal A.I. Moustafa

Kinetic Control in Synthesis and Self-Assembly　p. 21-43　2019　Part of collection (book)

Base-promoted lipase-catalyzed kinetic resolution of atropisomeric 1,1′-biaryl-2,2′-diols

Gamal A. I. Moustafa, Kengo Kasama, Koichi Higashio, Shuji Akai

RSC Adv.　Vol. 9　p. 1165-1175　2019/01　Research paper (scientific journal)

Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds

Takashi Ikawa, Shigeaki Masuda, Shuji Akai

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 66　No. 12　p. 1153-1164　2018/12　Research paper (scientific journal)

Flow Synthesis of (3R)- and (3S)-(E)-1-Iodohexa-1,5-dien-3-ol: Chiral Building Blocks for Natural Product Synthesis

Sota Katayama, Tomoyuki Koge, Satoko Katsuragi, Shuji Akai, Tohru Oishi

Chemistry Letters　Vol. 47　No. 9　p. 1116-1118　2018/09/05　Research paper (scientific journal)

Lipase-Catalyzed Dynamic Kinetic Resolution of C1- and C2-Symmetric Racemic Axially Chiral 2,2’-Dihydroxy-1,1’-biaryls

Gamal A. I. Moustafa, Yasuhiro Oki, Shuji Akai

Angewandte Chemie International Edition　Vol. 57　No. 32　p. 10278-10282　2018/08/06　Research paper (scientific journal)

Total synthesis of (-)-agelastatin A: an SH2’ radical azidation strategy

Izuru Tsuchimochi, Yuta Kitamura, Hiroshi Aoyama, Shuji Akai, Keiyo Nakai, Takehiko Yoshimitsu

Chem. Commun.　Vol. 54　p. 9893-9896　2018/08　Research paper (scientific journal)

3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives

Hideki Kaneko, Takashi Ikawa, Yuta Yamamoto, Sundaram Arulmozhiraja, Hiroaki Tokiwa, Shuji Akai

Synlett　Vol. 29　No. 07　p. 943-948　2018/04　Research paper (scientific journal)

Lipase-catalyzed asymmetric synthesis of naphtho[2,3-c]furan-1(3H)-one derivatives by a one-pot dynamic kinetic resolution/intramolecular Diels–Alder reaction: Total synthesis of (−)-himbacine

K. Sugiyama, S. Kawanishi, Y. Oki, M. Kamiya, R. Hanada, M. Egi, S. Akai

Bioorganic and Medicinal Chemistry　Vol. 26　No. 7　p. 1378-1386　2018/04/01　Research paper (scientific journal)

Synthesis of Optically Active 2,3-Disubstituted Indoline ­Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles

T. Ikawa, Y. Sumii, S. Masuda, D. Wang, Y. Emi, A. Takagi, S. Akai

Synlett　Vol. 29　No. 04　p. 530-536　2018/03　Research paper (scientific journal)

Dynamic Kinetic Resolution of Secondary Alcohols by Oxovanadium/Hydrolase Combo-Catalysis: Effective Use of Mesoporous Silicas

Shuji Akai

Zeolite　Vol. 35　p. 23-29　2018/01

Regioselective Rearrangement of 4,4-Disubstituted 2-Hydroxycyclohexa-2,5-Dienones under Deoxyfluorination Conditions

Keita Takubo, Ahmed A. B. Mohamed, Takafumi Ide, Kazuyuki Saito, Takashi Ikawa, Takehiko Yoshimitsu, Shuji Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 82　No. 24　p. 13141-13151　2017/12　Research paper (scientific journal)

MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells

Keisuke Ito, Yutaka Eguchi, Yusuke Imagawa, Shuji Akai, Hideki Mochizuki, Yoshihide Tsujimoto

Cell Death Discovery　Vol. 3　No. 1　2017/12　Research paper (scientific journal)

Atropisomeric Chiral Diiododienes (Z,Z)-2,3-Di(1-iodoalkylidene)tetralins: Synthesis, Enantiomeric Resolution, and Application in Asymmetric Catalysis

Masamichi Ogasawara, Hirotaka Sasa, Hao Hu, Yuta Amano, Hikaru Nakajima, Naoko Takenaga, Kiyohiko Nakajima, Yasuyuki Kita, Tamotsu Takahashi, Toshifumi Dohi

ORGANIC LETTERS　Vol. 19　No. 15　p. 4102-4105　2017/08　Research paper (scientific journal)

2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors

Takashi Ikawa, Shigeaki Masuda, Hiroki Nakajima, Shuji Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 82　No. 8　p. 4242-4253　2017/04　Research paper (scientific journal)

Dynamic Kinetic Resolution by Hydrolase-Metal Integrated Catalysis: A Novel Method for the Quantitative Conversion of Racemic Alcohols into Optically Pure Compounds

Shuji Akai

Journal of Synthetic Organic Chemistry, Japan　Vol. 75　No. 5　p. 441-448　2017　Research paper (scientific journal)

ラセミ体アルコールを光学的に純粋な化合物に収率100％で変換する新技術

赤井周司

和光純薬時報　Vol. 85　No. 1　p. 6-9　2017/01

Preparation of optically active cycloalkenes bearing all-carbon quaternary stereogenic centres via lipase-oxovanadium combo-catalysed dynamic kinetic resolution

Shinji Kawanishi, Koji Sugiyama, Yasuhiro Oki, Takashi Ikawa, Shuji Akai

GREEN CHEMISTRY　Vol. 19　No. 2　p. 411-417　2017/01　Research paper (scientific journal)

Glycosylation Reaction of Thioglycosides by Using Hypervalent Iodine(III) Reagent as an Excellent Promoter

Tetsuya Kajimoto, Koji Morimoto, Ryosuke Ogawa, Toshifumi Dohi, Yasuyuki Kita

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 64　No. 7　p. 838-844　2016/07　Research paper (scientific journal)

加水分解酵素を用いる不斉合成反応の新展開: 異分野との融合

赤井周司

化学と生物　Vol. 54　No. 6　p. 384-386　2016/05　Research paper (scientific journal)

Organo-Iodine(III)-Catalyzed Oxidative Phenol-Arene and Phenol-Phenol Cross-Coupling Reaction

Koji Morimoto, Kazuma Sakamoto, Takao Ohshika, Toshifumi Dohi, Yasuyuki Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 55　No. 11　p. 3652-3656　2016/03　Research paper (scientific journal)

Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate

Keita Takubo, Kazunori Furutsu, Takafumi Ide, Hiroyuki Nemoto, Yuko Ueda, Kazutake Tsujikawa, Takashi Ikawa, Takehiko Yoshimitsu, Shuji Akai

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　Vol. 2016　No. 8　p. 1562-1576　2016/03　Research paper (scientific journal)

Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

Koji Morimoto, Yusuke Ohnishi, Daichi Koseki, Akira Nakamura, Toshifumi Dohi, Yasuyuki Kita

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 14　No. 38　p. 8947-8951　2016　Research paper (scientific journal)

New Synthesis of Tetrahydrobenzodifurans by Iterative Coupling of Quinone Monoacetals with Alkene Nucleophiles

Yasuyuki Kita, Tohru Kamitanaka, Hitoho Takamuro, Kazuyuki Shimizu, Yudai Aramaki, Toshifumi Dohi

HETEROCYCLES　Vol. 93　No. 1　p. 295-295　2016　Research paper (scientific journal)

1,3- and 1,4-Benzdiyne equivalents for regioselective synthesis of polycyclic heterocycles

Takashi Ikawa, Shigeaki Masuda, Akira Takagi, Shuji Akai

Chemical Science　Vol. 7　No. 8　p. 5206-5211　2016　Research paper (scientific journal)

Spatial effects of oxovanadium-immobilized mesoporous silica on racemization of alcohols and application in lipase-catalyzed dynamic kinetic resolution

Koji Sugiyama, Yasuhiro Oki, Shinji Kawanishi, Katsuya Kato, Takashi Ikawa, Masahiro Egi, Shuji Akai

CATALYSIS SCIENCE & TECHNOLOGY　Vol. 6　No. 13　p. 5023-5030　2016　Research paper (scientific journal)

2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride Ion-Mediated Generation of Functionalized Benzynes

Takashi Ikawa, Rika Yamamoto, Akira Takagi, Toyohiro Ito, Kazunori Shimizu, Masahiko Goto, Yoshitaka Hamashima, Shuji Akai

ADVANCED SYNTHESIS & CATALYSIS　Vol. 357　No. 10　p. 2287-2300　2015/07　Research paper (scientific journal)

A new arylation of silyl enol ethers by quinone monoacetal substitution

Toshifumi Dohi, Tohru Kamitanaka, Hitoho Takamuro, Yusuke Mishima, Naohiko Washimi, Yasuyuki Kita

Tetrahedron Letters　Vol. 56　No. 23　p. 3046-3051　2015/06　Research paper (scientific journal)

Gold-Catalyzed Benzylic Azidation of Phthalans and Isochromans and Subsequent FeCl3-Catalyzed Nucleophilic Substitutions.

Shota Asai, Yuki Yabe, Ryota Goto, Saori Nagata, Yasunari Monguchi, Yasuyuki Kita, Hironao Sajiki, Yoshinari Sawama

Chemical & pharmaceutical bulletin　Vol. 63　No. 10　p. 757-61　2015　Research paper (scientific journal)

Phenol and Aniline Oxidative Coupling with Alkenes by Using Hypervalent Iodine Dimer for the Rapid Access to Dihydrobenzofurans and Indolines

Yasuyuki Kita, Toshifumi Dohi, Tomofumi Nakae, Yosuke Toyoda, Daichi Koseki, Hiroko Kubo, Tohru Kamitanaka

HETEROCYCLES　Vol. 90　No. 1　p. 631-631　2015　Research paper (scientific journal)

Transition Metal-Catalyzed Intramolecular Cyclization of Propargyl Alcohols and Their Derivatives for the Synthesis of Highly Substituted Five-Membered Oxygen Heterocycles

Masahiro Egi, Shuji Akai

HETEROCYCLES　Vol. 91　No. 5　p. 931-931　2015　Research paper (scientific journal)

Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

Saori Yokozawa, Noriyuki Ohneda, Ken Muramatsu, Tadashi Okamoto, Hiromichi Odajima, Takashi Ikawa, Jun-ichi Sugiyama, Masashi Fujita, Taira Sawairi, Hiromichi Egami, Yoshitaka Hamashima, Masahiro Egi, Shuji Akai

RSC ADVANCES　Vol. 5　No. 14　p. 10204-10210　2015　Research paper (scientific journal)

Central-axial-central chirality transfer: asymmetric synthesis of highly substituted indenes bearing a stereogenic quaternary carbon center from optically active propargyl alcohols

Masahiro Egi, Kaori Shimizu, Marin Kamiya, Yuya Ota, Shuji Akai

CHEMICAL COMMUNICATIONS　Vol. 51　No. 2　p. 380-383　2015　Research paper (scientific journal)

Trifluoromethanesulfonyloxy-group-directed regioselective (3+2) cycloadditions of benzynes for the synthesis of functionalized benzo-fused heterocycles

Takashi Ikawa, Hideki Kaneko, Shigeaki Masuda, Erika Ishitsubo, Hiroaki Tokiwa, Shuji Akai

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 13　No. 2　p. 520-526　2015　Research paper (scientific journal)

Concise Synthesis of Multisubstituted Isoquinolines from Pyridines by Regioselective Diels-Alder Reactions of 2-Silyl-3,4-pyridynes

Takashi Ikawa, Hirohito Urata, Yutaka Fukumoto, Yuta Sumii, Tsuyoshi Nishiyama, Shuji Akai

Chemistry - A European Journal　Vol. 20　No. 49　p. 16228-16232　2014/12/01　Research paper (scientific journal)

Real-Time Trafficking of PEGylated Liposomes in the Rodent Focal Brain Ischemia Analyzed by Positron Emission Tomography

Tatsuya Fukuta, Takayuki Ishii, Tomohiro Asai, Genki Nakamura, Yoshihito Takeuchi, Akihiko Sato, Yurika Agato, Kosuke Shimizu, Shuji Akai, Dai Fukumoto, Norihiro Harada, Hideo Tsukada, Akira T. Kawaguchi, Naoto Oku

ARTIFICIAL ORGANS　Vol. 38　No. 8　p. 662-666　2014/08　Research paper (scientific journal)

Enantiospecific Synthesis and Cytotoxicity Evaluation of Ligudentatol: A Programmed Aromatization Approach to the 2,3,4-Trisubstituted Phenolic Motif via Visible-Light-Mediated Group Transfer Radical Cyclization

Gamal A. I. Moustafa, Hiroshi Suizu, Hiroshi Aoyama, Masayoshi Arai, Shuji Akai, Takehiko Yoshimitsu

CHEMISTRY-AN ASIAN JOURNAL　Vol. 9　No. 6　p. 1506-1510　2014/06　Research paper (scientific journal)

Dynamic Kinetic Resolution of Racemic Allylic Alcohols via Hydrolase-Metal Combo Catalysis: An Effective Method for the Synthesis of Optically Active Compounds

Shuji Akai

CHEMISTRY LETTERS　Vol. 43　No. 6　p. 746-754　2014/06

Collaboration of Enzymes and Metallic Catalysts:A Novel Method for the Quantitative Conversion of Racemic Alcohols into Optically Pure Compounds

S. Akai

Manufacturing & Technology　Vol. 66　No. 2　p. 57-62　2014/04

Iodoarene-catalyzed fluorination and aminofluorination by an Ar-I/HF.pyridine/mCPBA system

Satoru Suzuki, Tomohiro Kamo, Kazunobu Fukushi, Takaaki Hiramatsu, Etsuko Tokunaga, Toshifumi Dohi, Yasuyuki Kita, Norio Shibata

CHEMICAL SCIENCE　Vol. 5　No. 7　p. 2754-2760　2014　Research paper (scientific journal)

New Site-Selective Organoradical Based on Hypervalent Iodine Reagent for Controlled Alkane sp(3) C-H Oxidations

Toshifumi Dohi, Yasuyuki Kita

CHEMCATCHEM　Vol. 6　No. 1　p. 76-78　2014/01

EFFICIENT OXIDATIVE SPIROLACTAMIZATION BY mu-OXO BRIDGED HETEROCYCLIC HYPERVALENT IODINE COMPOUND

Toshifumi Dohi, Eisuke Mochizuki, Daisuke Yamashita, Keitaro Miyazaki, Yasuyuki Kita

HETEROCYCLES　Vol. 88　No. 1　p. 245-260　2014/01　Research paper (scientific journal)

Synthesis of Fluorinated Aromatic Compounds by One-Pot Benzyne Generation and Nucleophilic Fluorination

Takashi Ikawa, Shigeaki Masuda, Tsuyoshi Nishiyama, Akira Takagi, Shuji Akai

AUSTRALIAN JOURNAL OF CHEMISTRY　Vol. 67　No. 3　p. 475-480　2014　Research paper (scientific journal)

ortho-Selective nucleophilic addition of amines to 3-borylbenzynes: synthesis of multisubstituted anilines by the triple role of the boryl group

Akira Takagi, Takashi Ikawa, Kozumo Saito, Shigeaki Masuda, Toyohiro Ito, Shuji Akai

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 11　No. 46　p. 8145-8150　2013/12　Research paper (scientific journal)

Dress-up chiral columns for the enantioseparation of amino acids based on fluorous separation

Kenichiro Todoroki, Yasuhiro Ishii, Koji Toyoda, Takashi Ikawa, Jun Zhe Min, Koichi Inoue, Shuji Akai, Toshimasa Toyo'oka

ANALYTICAL AND BIOANALYTICAL CHEMISTRY　Vol. 405　No. 25　p. 8121-8129　2013/10　Research paper (scientific journal)

A Penicillium sp F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice

Yasuhiro Yamazaki, Kengo Yasuda, Tensei Matsuyama, Takuya Ishihara, Ryoko Higa, Taira Sawairi, Masahiko Yamaguchi, Masahiro Egi, Shuji Akai, Toshio Miyase, Akira Ikari, Masao Miwa, Junko Sugatani

BIOCHEMICAL PHARMACOLOGY　Vol. 86　No. 5　p. 632-644　2013/09　Research paper (scientific journal)

Efficient Intramolecular Cyclizations of Phenoxyethynyl Diols into Multisubstituted alpha,beta-Unsaturated Lactones

Masahiro Egi, Yuya Ota, Yuka Nishimura, Kaori Shimizu, Kenji Azechi, Shuji Akai

ORGANIC LETTERS　Vol. 15　No. 16　p. 4150-4153　2013/08　Research paper (scientific journal)

Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [F-18]Deoxyfluoropoly(ethylene glycol)

Tadayuki Takashima, Tomotaka Shingaki, Yumiko Katayama, Emi Hayashinaka, Yasuhiro Wada, Makoto Kataoka, Daiki Ozaki, Hisashi Doi, Masaaki Suzuki, Sho Ishida, Kentaro Hatanaka, Yuichi Sugiyama, Shuji Akai, Naoto Oku, Shinji Yamashita, Yasuyoshi Watanabe

MOLECULAR PHARMACEUTICS　Vol. 10　No. 6　p. 2261-2269　2013/06　Research paper (scientific journal)

Generation of 3-borylbenzynes, their regioselective Diels-Alder reactions, and theoretical analysis

Akira Takagi, Takashi Ikawa, Yurio Kurita, Kozumo Saito, Kenji Azechi, Masahiro Egi, Yuji Itoh, Hiroaki Tokiwa, Yasuyuki Kita, Shuji Akai

TETRAHEDRON　Vol. 69　No. 21　p. 4338-4352　2013/05　Research paper (scientific journal)

Development of the resonator-type microwave reactor for organic flow synthesis

Vol. 113　No. 12　p. 9-14　2013/04　Research paper (scientific journal)

Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives

Takashi Ikawa, Akira Takagi, Masahiko Goto, Yuya Aoyama, Yoshinobu Ishikawa, Yuji Itoh, Satoshi Fujii, Hiroaki Tokiwa, Shuji Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 78　No. 7　p. 2965-2983　2013/04　Research paper (scientific journal)

Asymmetric Dearomatizing Spirolactonization of Naphthols Catalyzed by Spirobiindane-Based Chiral Hypervalent Iodine Species

Toshifumi Dohi, Naoko Takenaga, Tomofumi Nakae, Yosuke Toyoda, Mikio Yamasaki, Motoo Shiro, Hiromichi Fujioka, Akinobu Maruyama, Yasuyuki Kita

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 135　No. 11　p. 4558-4566　2013/03　Research paper (scientific journal)

Discovery of Aromatic Components with Excellent Fragrance Properties and Biological Activities: beta-Ionols with Antimelanogenetic Effects and Their Asymmetric Syntheses

Ryoichi Komaki, Takashi Ikawa, Kozumo Saito, Kazuyo Hattori, Natsuyo Ishikawa, Hidemichi Fukawa, Masahiro Egi, Shuji Akai

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 61　No. 3　p. 310-314　2013/03　Research paper (scientific journal)

Lewis acid-catalyzed ring-opening functionalizations of 1,4-epoxy-1,4-dihydronaphthalenes

Yoshinari Sawama, Yuta Ogata, Koichi Kawamoto, Hiroyuki Satake, Kyoshiro Shibata, Yasunari Monguchi, Hironao Sajiki, Yasuyuki Kita

Advanced Synthesis and Catalysis　Vol. 355　No. 2-3　p. 517-528　2013/02/11　Research paper (scientific journal)

Efficient generation of ortho-naphthoquinone methides from 1,4-epoxy-1,4-dihydronaphthalenes and their annulation with allyl silanes.

Yoshinari Sawama, Yuko Shishido, Takayoshi Yanase, Koichi Kawamoto, Ryota Goto, Yasunari Monguchi, Yasuyuki Kita, Hironao Sajiki

Angewandte Chemie (International ed. in English)　Vol. 52　No. 5　p. 1515-9　2013/01/28　Research paper (scientific journal)

A Mesoporous-Silica-Immobilized Oxovanadium Cocatalyst for the Lipase-Catalyzed Dynamic Kinetic Resolution of Racemic Alcohols

Masahiro Egi, Koji Sugiyama, Moriaki Saneto, Ryosuke Hanada, Katsuya Kato, Shuji Akai

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 52　No. 13　p. 3654-3658　2013　Research paper (scientific journal)

Experimental and Theoretical Studies on Regiocontrol of Benzyne Reactions Using Silyl and Boryl Directing Groups

Ikawa, Takashi, Tokiwa, Hiroaki, Akai, Shuji

Journal of Synthetic Organic Chemistry, Japan　Vol. 70　No. 11　p. 1123-1133　2012/12　Research paper (scientific journal)

Efficient Synthesis of Oxygenated Terphenyls and Other Oligomers: Sequential Arylation Reactions Through Phenol Oxidation-Rearomatization

Toshifumi Dohi, Tohru Kamitanaka, Shohei Watanabe, Yinjun Hu, Naohiko Washimi, Yasuyuki Kita

Chemistry - A European Journal　Vol. 18　No. 43　p. 13614-13618　2012/10/22　Research paper (scientific journal)

Controlled couplings of quinone monoacetals using reusable polystyrene-anchored specific proton catalyst

Toshifumi Dohi, Yinjun Hu, Tohru Kamitanaka, Yasuyuki Kita

Tetrahedron　Vol. 68　No. 40　p. 8424-8430　2012/10　Research paper (scientific journal)

Palladium-Catalyzed One-Pot Cross-Coupling of Phenols Using Nonafluorobutanesulfonyl Fluoride

Takashi Ikawa, Kozumo Saito, Shuji Akai

SYNLETT　Vol. 23　No. 15　p. 2241-2246　2012/09　Research paper (scientific journal)

Protecting-group-free catalytic asymmetric total synthesis of (-)-rosmarinecine

Hiroyuki Nemoto, Kouichi Tanimoto, Yukiko Kanao, Sohei Omura, Yasuyuki Kita, Shuji Akai

TETRAHEDRON　Vol. 68　No. 36　p. 7295-7301　2012/09　Research paper (scientific journal)

Regiocomplementary Synthesis of Fluorinated Bridged Biphenyls

Hiroyuki Nemoto, Keita Takubo, Kazuki Shimizu, Shuji Akai

Synlett　Vol. 23　No. 13　p. 1978-1984　2012/08　Research paper (scientific journal)

Heteropolyacid-Catalyzed Direct Deoxygenation of Propargyl and Allyl Alcohols

Masahiro Egi, Takuya Kawai, Megumi Umemura, Shuji Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 77　No. 16　p. 7092-7097　2012/08　Research paper (scientific journal)

Reaction of Acetals with Various Carbon Nucleophiles under Non-Acidic Conditions: C-C Bond Formation via a Pyridinium-Type Salt

Hiromichi Fujioka, Kenzo Yahata, Tomohito Hamada, Ozora Kubo, Takashi Okitsu, Yoshinari Sawama, Takuya Ohnaka, Tomohiro Maegawa, Yasuyuki Kita

CHEMISTRY-AN ASIAN JOURNAL　Vol. 7　No. 2　p. 367-373　2012/02　Research paper (scientific journal)

An excellent dual recycling strategy for the hypervalent iodine/nitroxyl radical mediated selective oxidation of alcohols to aldehydes and ketones

Toshifumi Dohi, Kei-ichiro Fukushima, Tohru Kamitanaka, Koji Morimoto, Naoko Takenaga, Yasuyuki Kita

Green Chemistry　Vol. 14　No. 5　p. 1493-1493　2012　Research paper (scientific journal)

Hypervalent Iodine Induced Metal-Free C-H Cross Couplings to Biaryls

Yasuyuki Kita, Toshifumi Dohi, Koji Morimoto

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN　Vol. 69　No. 11　p. 1241-1250　2011/11　Research paper (scientific journal)

[3 + 2] Coupling of Quinone Monoacetals by Combined Acid–Hydrogen Bond Donor

Toshifumi Dohi, Yinjun Hu, Tohru Kamitanaka, Naohiko Washimi, Yasuyuki Kita

Organic Letters　Vol. 13　No. 18　p. 4814-4817　2011/09/16　Research paper (scientific journal)

ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines

Takashi Ikawa, Tsuyoshi Nishiyama, Takashi Shigeta, Shinya Mohri, Shinsuke Morita, Sho-ichi Takayanagi, Yuki Terauchi, Yuki Morikawa, Akira Takagi, Yoshinobu Ishikawa, Satoshi Fujii, Yasuyuki Kita, Shuji Akai

Angewandte Chemie International Edition　Vol. 50　No. 25　p. 5674-5677　2011/06/14　Research paper (scientific journal)

Nucleophilic Deoxyfluorination of Catechols

Hiroyuki Nemoto, Tsuyoshi Nishiyama, Shuji Akai

ORGANIC LETTERS　Vol. 13　No. 10　p. 2714-2717　2011/05　Research paper (scientific journal)

A Domino Process for Benzyne Preparation: Dual Activation of o-(Trimethylsilyl)phenols by Nonafluorobutanesulfonyl Fluoride

Takashi Ikawa, Tsuyoshi Nishiyama, Toshifumi Nosaki, Akira Takagi, Shuji Akai

ORGANIC LETTERS　Vol. 13　No. 7　p. 1730-1733　2011/04　Research paper (scientific journal)

Reusable and Durable Immobilized-Cationic Gold(I) Catalysts for Environmentally Benign Bond-Forming Reactions

Masahiro Egi, Kenji Azechi, Shuji Akai

ADVANCED SYNTHESIS & CATALYSIS　Vol. 353　No. 2-3　p. 287-290　2011/02　Research paper (scientific journal)

Discovery of Stabilized Bisiodonium Salts as Intermediates in the Carbon-Carbon Bond Formation of Alkynes

Toshifumi Dohi, Daishi Kato, Ryo Hyodo, Daisuke Yamashita, Motoo Shiro, Yasuyuki Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 50　No. 16　p. 3784-3787　2011　Research paper (scientific journal)

Heteropoly Compound Catalyzed Synthesis of Both Z- and E-a,ss-Unsaturated Carbonyl Compounds

Masahiro Egi, Megumi Umemura, Takuya Kawai, Shuji Akai

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 50　No. 51　p. 12197-12200　2011　Research paper (scientific journal)

Synthesis of Long-Chain [F-18]Deoxyfluoropoly(ethylene glycol) Methyl Ethers and Their Noninvasive Pharmacokinetic Analysis by Positron Emission Tomography

Shuji Akai, Sho Ishida, Kentaro Hatanaka, Takayuki Ishii, Norihiro Harada, Hideo Tsukada, Naoto Oku

MOLECULAR PHARMACEUTICS　Vol. 8　No. 1　p. 302-308　2011/01　Research paper (scientific journal)

PET imaging of brain cancer with positron emitter-labeled liposomes

Naoto Oku, Mina Yamashita, Yurie Katayama, Takeo Urakami, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Hideo Tsukada, Shuji Akai, Hiroaki Kanazawa

INTERNATIONAL JOURNAL OF PHARMACEUTICS　Vol. 403　No. 1-2　p. 170-177　2011/01　Research paper (scientific journal)

One-Pot Synthesis of Optically Active Allyl Esters via Lipase-Vanadium Combo Catalysis

Shuji Akai, Ryosuke Hanada, Noboru Fujiwara, Yasuyuki Kita, Masahiro Egi

ORGANIC LETTERS　Vol. 12　No. 21　p. 4900-4903　2010/11　Research paper (scientific journal)

Diblock Copolymer of Bacterial Cellulose and Poly(methyl methacrylate) Initiated by Chain-End-Type Radicals Produced by Mechanical Scission of Glycosidic Linkages of Bacterial Cellulose

Masato Sakaguchi, Takeshi Ohura, Tadahisa Iwata, Shuhei Takahashi, Shuji Akai, Toshiyuki Kan, Hisao Murai, Motoyasu Fujiwara, Osamu Watanabe, Mamiko Narita

BIOMACROMOLECULES　Vol. 11　No. 11　p. 3059-3066　2010/11　Research paper (scientific journal)

Csp3–H 結合の触媒的官能基化に挑む！

根本裕之, 赤井周司

化学　Vol. 65　No. 10　p. 66-67　2010/10

Metal-Free Regioselective Oxidative Biaryl Coupling Leading to Head-to-Tail Bithiophenes: Reactivity Switching, a Concept Based on the Iodonium(III) Intermediate

Koji Morimoto, Nobutaka Yamaoka, Chieko Ogawa, Tomofumi Nakae, Hiromichi Fujioka, Toshifumi Dohi, Yasuyuki Kita

ORGANIC LETTERS　Vol. 12　No. 17　p. 3804-3807　2010/09　Research paper (scientific journal)

Preparation and Regioselective Diels-Alder Reactions of Borylbenzynes: Synthesis of Functionalized Arylboronates

Takashi Ikawa, Akira Takagi, Yurio Kurita, Kozumo Saito, Kenji Azechi, Masahiro Egi, Keisuke Kakiguchi, Yasuyuki Kita, Shuji Akai

Angewandte Chemie　Vol. 122　No. 32　p. 5695-5698　2010/07/02　Research paper (scientific journal)

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Shuji Akai, Takayuki Ishii, Eriya Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, Hideo Tsukada, Naoto Oku

INTERNATIONAL JOURNAL OF PHARMACEUTICS　Vol. 392　No. 1-2　p. 218-223　2010/06　Research paper (scientific journal)

Cationic Gold(I)-Catalyzed Intramolecular Cyclization of gamma-Hydroxyalkynones into 3(2H)-Furanones

Masahiro Egi, Kenji Azechi, Moriaki Saneto, Kaori Shimizu, Shuji Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 75　No. 6　p. 2123-2126　2010/03　Research paper (scientific journal)

Preparation and Regioselective Diels-Alder Reactions of Borylbenzynes: Synthesis of Functionalized Arylboronates

Takashi Ikawa, Akira Takagi, Yurio Kurita, Kozumo Saito, Kenji Azechi, Masahiro Egi, Keisuke Kakiguchi, Yasuyuki Kita, Shuji Akai

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 49　No. 32　p. 5563-5566　2010　Research paper (scientific journal)

長鎖[18F]デオキシフルオロPEGの合成とPETイメージングによる体内動態解析

石田 翔, 畑中剣太朗, 石井貴之, 原田典弘, 塚田秀夫, 奥 直人, 赤井周司

Progress in Drug Delivery System　Vol. XIX　p. 41-46　2010/01　Research paper (scientific journal)

Dynamic kinetic resolution of allyl alcohols by the combined use of lipases and VO(OSiPh3)(3): Application to various substrates

Masahiro Egi, Noboru Fujiwara, Yoshiko Yamaguchi, Ryosuke Hanada, Shuji Akai

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC　Vol. 62　No. 1　p. 123-+　2010/01　Research paper (scientific journal)

Cationic Goid(I)-Mediated Intramolecular Cyclization of 3-Alkyne-1,2-diols and 1-Amino-3-alkyn-2-ols: A Practical Route to Furans and Pyrroles

Masahiro Egi, Kenji Azechi, Shuji Akai

ORGANIC LETTERS　Vol. 11　No. 21　p. 5002-5005　2009/11　Research paper (scientific journal)

Synthesis of Various Kinds of Isoflavones, Isoflavanes, and Biphenyl-Ketones and Their 1,1-Diphenyl-2-picrylhydrazyl Radical-Scavenging Activities

Hideyuki Goto, Yoshiyasu Terao, Shuji Akai

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 57　No. 4　p. 346-360　2009/04　Research paper (scientific journal)

In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography

Takeo Urakami, Akira T. Kawaguchi, Shuji Akai, Kentaro Hatanaka, Hiroyuki Koide, Kosuke Shimizu, Tomohiro Asai, Dai Fukumoto, Norihiro Harada, Hideo Tsukada, Naoto Oku

Artificial Organs　Vol. 33　No. 2　p. 164-168　2009/02　Research paper (scientific journal)

Mo-Au combo catalysis for rapid 1,3-rearrangement of propargyl alcohols into alpha,beta-unsaturated carbonyl compounds

Masahiro Egi, Yoshiko Yamaguchi, Noboru Fujiwara, Shuji Akai

ORGANIC LETTERS　Vol. 10　No. 9　p. 1867-1870　2008/05　Research paper (scientific journal)

Oxidative cross-coupling of arenes induced by single-electron transfer leading to biaryls by use of organoiodine(III) oxidants

Toshifumi Dohi, Motoki Ito, Koji Morimoto, Minako Wata, Yasuyuki Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 47　No. 7　p. 1301-1304　2008　Research paper (scientific journal)

Enantioselective Synthesis of Both Enantiomers of Etodolac via a Lipase-Catalyzed Kinetic Resolution

Shuji Akai, Hiroyuki Nemoto, Masahiro Egi

HETEROCYCLES　Vol. 76　No. 2　p. 1537-1537　2008　Research paper (scientific journal)

Synthesis of biaryl compounds through three-component assembly: Ambidentate effect of the tert-butyldimethylsilyl group for regioselective Diels-Alder and Hiyama coupling reactions

Shuji Akai, Takashi Ikawa, Sho-ichi Takayanagi, Yuki Morikawa, Shinya Mohri, Masaya Tsubakiyama, Masahiro Egi, Yasufami Wada, Yasuyuki Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 47　No. 40　p. 7673-7676　2008　Research paper (scientific journal)

New perspective for natural products synthesis: Concise synthesis of (+)-Sch 642305 by chiral auxiliary multiuse methodology

Hiromichi Fujioka, Yusuke Ohba, Kenji Nakahara, Mayuko Takatsuji, Kenichi Murai, Motoki Ito, Yasuyuki Kita

ORGANIC LETTERS　Vol. 9　No. 26　p. 5605-5608　2007/12　Research paper (scientific journal)

Novel amphiphilic probes for [F-18]-radiolabeling preformed liposomes and determination of liposomal trafficking by positron emission tomography

Takeo Urakami, Shuji Akai, Yurie Katayama, Norihiro Harada, Hideo Tsukada, Naoto Oku

JOURNAL OF MEDICINAL CHEMISTRY　Vol. 50　No. 26　p. 6454-6457　2007/12　Research paper (scientific journal)

Organic chemistry using weakly electrophilic salts: Efficient formation of O,O-mixed, O,S- and N,O-acetals

Hiromichi Fujioka, Takashi Okitsu, Takuya Ohnaka, Ruichuan Li, Ozora Kubo, Kazuhisa Okamoto, Yoshinari Sawama, Yasuyuki Kita

JOURNAL OF ORGANIC CHEMISTRY　Vol. 72　No. 21　p. 7898-7902　2007/10　Research paper (scientific journal)

Direct lactone formation by using hypervalent Iodine(III) reagents with KBr via selective C-H abstraction protocol

Toshifumi Dohi, Naoko Takenaga, Akihiro Goto, Akinobu Maruyama, Yasuyuki Kita

ORGANIC LETTERS　Vol. 9　No. 16　p. 3129-3132　2007/08　Research paper (scientific journal)

Versatile direct dehydrative approach for diaryliodonium(III) salts in fluoroalcohol media

Toshifumi Dohi, Motoki Ito, Koji Morimoto, Yutaka Minamitsuji, Naoko Takenaga, Yasuyuki Kita

CHEMICAL COMMUNICATIONS　No. 40　p. 4152-4154　2007　Research paper (scientific journal)

Total synthesis of (+/-)-gamma-Rubromycin on the basis of two aromatic pummerer-type reactions

Shuji Akai, Keisuke Kakiguchi, Yuka Nakamura, Ikumi Kuriwaki, Toshifumi Dohi, Shusaku Harada, Ozora Kubo, Nobuyoshi Morita, Yasuyuki Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 46　No. 39　p. 7458-7461　2007　Research paper (scientific journal)

Recent Progress on the Lipase-Catalyzed Asymmetric Syntheses

Shuji Akai, Yasuyuki Kita

Journal of Synthetic Organic Chemistry, Japan　Vol. 65　No. 8　p. 772-782　2007

Recent advances in Pummerer reactions

Shuji Akai, Yasuyuki Kita

SULFUR-MEDIATED REARRANGEMENTS I　Vol. 274　p. 35-76　2007　Part of collection (book)

Dynamic kinetic resolution of racemic allyl alcohols by the combined use of lipases and VO(OSiPh3)(3) - Abstracts

Shuji Akai, Yukiko Kanao, Kouichi Tanimoto, Masahiro Egi, Tomoko Yamamoto, Yasuyuki Kita

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC　Vol. 42　No. 3-4　p. 132-132　2006/11

P-194 Preparation of Optically Active Allyl Acetates by Lipase-Catalyzed Dynamic Kinetic Resolution

Akai Shuji, Kanao Yukiko, Tanimoto Kouichi, Egi Masahiro, Yamamoto Tomoko, Kita Yasuyuki

International Symposium on the Chemistry of Natural Products　Vol. 2006　p. "P-194"　2006/07/23

Regioselective, nucleophilic carbon-carbon bond formation at the C4-position of indoles initiated by the aromatic Pummerer-type reaction

Shuji Akai, Norihito Kawashita, Yasufumi Wada, Hideharu Satoh, Anahita, Hessamian Alinejad, Keisuke Kakiguchi, Ikumi Kuriwaki, Yasuyuki Kita

TETRAHEDRON LETTERS　Vol. 47　No. 12　p. 1881-1884　2006/03　Research paper (scientific journal)

A dynamic kinetic esolution of allyl alcohols by the combined use of lipases and [VO(OSiPh3)(3)]

S Akai, K Tanimoto, Y Kanao, M Egi, T Yanamoto, Y Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 45　No. 16　p. 2592-2595　2006　Research paper (scientific journal)

Asymmetric total synthesis of fredericamycin A: An intramolecular cycloaddition pathway

S Akai, T Tsujino, N Fukuda, K Iio, Y Takeda, K Kawaguchi, T Naka, K Higuchi, E Akiyama, H Fujioka, Y Kita

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 11　No. 21　p. 6286-6297　2005/10　Research paper (scientific journal)

Asymmetric synthesis by the intramolecular haloetherification reaction of ene acetal: Discrimination of prochiral dienes in cyclohexane systems

Hiromichi Fujioka, Naoyuki Kotoku, Yoshinari Sawama, Hidetoshi Kitagawa, Yusuke Ohba, Tsung-Lung Wang, Yasushi Nagatomi, Yasuyuki Kita

Chemical and Pharmaceutical Bulletin　Vol. 53　No. 8　p. 952-957　2005/08　Research paper (scientific journal)

リパーゼ触媒ドミノ型不斉分子構築法 (特集1 プロセスケミストリーと分離技術)

赤井 周司

分離技術　Vol. 35　No. 6　p. 379-385　2005

Lipase-catalyzed domino kinetic resolution of alpha-hydroxynitrones/intramolecular 1,3-dipolar cycloaddition: a concise asymmetric total synthesis of (-)-rosmarinecine

S Akai, K Tanimoto, Y Kanao, S Omura, Y Kita

CHEMICAL COMMUNICATIONS　No. 18　p. 2369-2371　2005　Research paper (scientific journal)

Asymmetric desymmetrization based on an intramolecular haloetherification: A highly effective and recyclable chiral nonracemic auxiliary, 2-exo-methyl-3-endo-phenyl-5-norbornene-2-carboxaldehyde, for meso-1,3- and meso-1,4-diols

Hiromichi Fujioka, Tetsuya Fujita, Naoyuki Kotoku, Yusuke Ohba, Yasushi Nagatomi, Atsushi Hiramatsu, Yasuyuki Kita

Chemistry - A European Journal　Vol. 10　No. 21　p. 5386-5397　2004/10/25　Research paper (scientific journal)

Highly Regioselective Nucleophilic Carbon−Carbon Bond Formation on Furans and Thiophenes Initiated by Pummerer-Type Reaction

Shuji Akai, Norihito Kawashita, Hideharu Satoh, Yasufumi Wada, Keisuke Kakiguchi, Ikumi Kuriwaki, Yasuyuki Kita

Organic Letters　Vol. 6　No. 21　p. 3793-3796　2004/10/01　Research paper (scientific journal)

Enantiodivergent preparation of optically active oxindoles having a stereogenic quaternary carbon center at the C3 position via the lipase-catalyzed desymmetrization protocol: Effective use of 2-furoates for either enzymatic esterification or hydrolysis

S Akai, T Tsujino, E Akiyama, K Tanimoto, T Naka, Y Kita

JOURNAL OF ORGANIC CHEMISTRY　Vol. 69　No. 7　p. 2478-2486　2004/04　Research paper (scientific journal)

Lipase-catalyzed domino dynamic kinetic resolution of racemic 3-vinylcyclohex-2-en-1-ols/intramolecular Diels-Alder reaction: One-pot synthesis of optically active polysubstituted decalins

S Akai, K Tanimoto, Y Kita

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 43　No. 11　p. 1407-1410　2004　Research paper (scientific journal)

1-alkoxyvinyl esters: Renaissance of half-century-old acyl donors with potential applicability

Y Kita, S Akai

CHEMICAL RECORD　Vol. 4　No. 6　p. 363-372　2004

Development of Novel Asymmetric Reactions Oriented to Next-Generation Enzymatic Organic Syntheses

Shuji AKAI

YAKUGAKU ZASSHI　Vol. 123　No. 11　p. 919-931　2003/11/01　Research paper (scientific journal)

Optical resolution of (+/-)-1-furo[2,3-c]pyridin-5-yl-ethanol using extraction technique: formal total synthesis of PNU-142721, HIV-1 reverse transcriptase inhibitor

M Matsugi, K Itoh, M Nojima, Y Hagimoto, Y Kita

TETRAHEDRON LETTERS　Vol. 44　No. 16　p. 3355-3358　2003/04　Research paper (scientific journal)

Synthesis of p-phenylthio- peri-hydroxy polyaromatic compounds by strong-base-induced [4+2] cycloaddition of 4(phenylthio)homophthalic anhydrides with phenylsulfinyl-dienophiles

K Iio, A Okajima, Y Takeda, K Kawaguchi, BA Whelan, S Akai, Y Kita

ARKIVOC　p. 144-162　2003　Research paper (scientific journal)

Regioselective synthesis of 2,3,5-trisubstituted indoles from p-sulfinylaniline by dual use of the sulfinyl group

S Akai, N Kawashita, N Morita, Y Nakamura, K Iio, Y Kita

HETEROCYCLES　Vol. 58　p. 75-78　2002/11　Research paper (scientific journal)

Lipase-catalyzed domino kinetic resolution/intramolecular Diels-Alder reaction: One-pot synthesis of optically active 7-oxabicyclo[2.2.1]heptenes from furfuryl alcohols and beta-substituted acrylic acids

S Akai, T Naka, S Omura, K Tanimoto, M Imanishi, Y Takebe, M Matsugi, Y Kita

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 8　No. 18　p. 4255-4264　2002/09　Research paper (scientific journal)

Efficient lipase-catalyzed enantioselective desymmetrization of prochiral 2,2-disubstituted 1,3-propanediols and meso 1,2-diols using 1-ethoxyvinyl 2-furoate

S Akai, T Naka, T Fujita, Y Takeba, T Tsujino, Y Kita

JOURNAL OF ORGANIC CHEMISTRY　Vol. 67　No. 2　p. 411-419　2002/01　Research paper (scientific journal)

Enantiodivergent synthesis of either enantiomer of ABCDE-ring analogue of antitumor antibiotic fredericamycin A via intramolecular [4+2] cycloaddition approach

S Akai, T Tsujino, N Fukuda, K Iio, Y Takeda, KI Kawaguchi, T Naka, K Higuchi, Y Kita

ORGANIC LETTERS　Vol. 3　No. 25　p. 4015-4018　2001/12　Research paper (scientific journal)

Lipase-catalyzed enantioselective desymmetrization of prochiral 3,3-bis(hydroxymethyl)oxindoles

S Akai, T Tsujino, T Naka, K Tanimoto, Y Kita

TETRAHEDRON LETTERS　Vol. 42　No. 41　p. 7315-7317　2001/10　Research paper (scientific journal)

Enantioselective total synthesis of a potent antitumor antibiotic, fredericamycin A

Y Kita, K Higuchi, Y Yoshida, K Iio, S Kitagaki, K Ueda, S Akai, H Fujioka

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 123　No. 14　p. 3214-3222　2001/04

Efficient oxidative biaryl coupling reaction of phenol ether derivatives using hypervalent iodine(III) reagents

Hirofumi Tohma, Hironori Morioka, Shinobu Takizawa, Mitsuhiro Arisawa, Yasuyuki Kita

Tetrahedron　Vol. 57　No. 2　p. 345-352　2001/01/07　Research paper (scientific journal)

Development of Lipase-Catalyzed Novel Asymmetric Synthesis

The Production & Technique　Vol. 53　No. 3　p. 57-60　2001

Total synthesis of the antitumor antibiotic (+/-)-fredericamycin A by a linear approach

Y Kita, K Iio, K Kawaguchi, N Fukuda, Y Takeda, H Ueno, R Okunaka, K Higuchi, T Tsujino, H Fujioka, S Akai

CHEMISTRY-A EUROPEAN JOURNAL　Vol. 6　No. 21　p. 3897-3905　2000/11　Research paper (scientific journal)

Lipase-catalyzed asymmetric desymmetrization of prochiral 2,2-disubstituted 1,3-propanediols using 1-ethoxyvinyl benzoate

S Akai, T Naka, Y Takebe, Y Kita

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 48　No. 10　p. 1519-1523　2000/10　Research paper (scientific journal)

Ambident effect of a p-sulfinyl group for the introduction of two carbon substituents to phenol rings: A convergent synthesis of diverse benzofuran neolignans

S Akai, N Morita, K Iio, Y Nakamura, Y Kita

ORGANIC LETTERS　Vol. 2　No. 15　p. 2279-2282　2000/07　Research paper (scientific journal)

Facile and clean oxidation of alcohols in water using hypervalent iodine(III) reagents

Hirofumi Tohma, Shinobu Takizawa, Tomohiro Maegawa, Yasuyuki Kita

Angewandte Chemie - International Edition　Vol. 39　No. 7　p. 1306-1308　2000/04　Research paper (scientific journal)

フレデリカマイシンAの全合成

北 泰行, 赤井 周司, 藤岡 弘道

現代化学 増刊　Vol. 36　p. 102-116　2000

Convenient enzymatic resolution of alcohols using highly reactive, nonharmful acyl donors, 1-ethoxyvinyl esters

Y Kita, Y Takebe, K Murata, T Naka, S Akai

JOURNAL OF ORGANIC CHEMISTRY　Vol. 65　No. 1　p. 83-88　2000/01　Research paper (scientific journal)

1-Ethoxyvinyl 2-furoate, an efficient acyl donor for the lipase-catalyzed enantioselective desymmetrization of prochiral 2,2-disubstituted propane-1,3-diols and meso-1,2-diols

Shuji Akai, Tadaatsu Naka, Tetsuya Fujita, Yasushi Takebe, Yasuyuki Kita

Chemical Communications　No. 16　p. 1461-1462　2000　Research paper (scientific journal)

An efficient synthesis of peri-hydroxy aromatic compounds via a strong-base-induced [4+2] cycloaddition of homophthalic anhydrides with enolizable enones

K Iio, NG Ramesh, A Okajima, K Higuchi, H Fujioka, S Akai, Y Kita

JOURNAL OF ORGANIC CHEMISTRY　Vol. 65　No. 1　p. 89-95　2000/01　Research paper (scientific journal)

Development of Novel Reactions Using Hypervalent Iodine(III) Reagents: Total Synthesis of Sulfur-Containing Pyrroloiminoquinone Marine Product, (±)-Makaluvamine F

Yasuyuki Kita, Masahiro Egi, Takeshi Takada, Hirofumi Tohma

Synthesis　Vol. 1999　No. 05　p. 885-897　1999/05　Research paper (scientific journal)

An unexpected intermolecular chiral biaryl coupling reaction induced by a hypervalent iodine(III) reagent: Synthesis of potential precursor for ellagitannin

Mitsuhiro Arisawa, Saori Utsumi, Makiko Nakajima, Namakkal G. Ramesh, Hirofumi Tohma, Yasuyuki Kita

Chemical Communications　No. 5　p. 469-470　1999/03/07　Research paper (scientific journal)

Studies on Total Synthesis of Antitumor Antibiotic, Fredericamycin A

Vol. 15　p. 21-29　1999

Asymmetric total synthesis of fredericamycin A

Y Kita, K Higuchi, Y Yoshida, K Iio, S Kitagaki, S Akai, H Fujioka

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 38　No. 5　p. 683-686　1999　Research paper (scientific journal)

A strong-base induced [4+2] cycloaddition of homophthalic anhydrides with enolizable enones: a direct and efficient synthesis of peri-hydroxy aromatic compounds

NG Ramesh, K Iio, A Okajima, S Akai, Y Kita

CHEMICAL COMMUNICATIONS　No. 24　p. 2741-2742　1998/12　Research paper (scientific journal)

Recent progress in the synthesis of p-quinones and p-dihydro-quinones through oxidation of phenol derivative. A review

S Akai, Y Kita

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL　Vol. 30　No. 6　p. 603-629　1998/12

Oxidative biaryl coupling reaction of phenol ether derivatives using a hypervalent lodine(III) reagent

Takeshi Takada, Mitsuhiro Arisawa, Michiyo Gyoten, Ryuji Hamada, Hirofumi Tohma, Yasuyuki Kita

Journal of Organic Chemistry　Vol. 63　No. 22　p. 7698-7706　1998/10/30　Research paper (scientific journal)

Regioselective, directed meta acylation of aromatic compounds

S Akai, AJ Peat, SL Buchwald

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 120　No. 36　p. 9119-9125　1998/09　Research paper (scientific journal)

Asymmetric Diels-Alder reaction via enzymatic kinetic resolution using ethoxyvinyl methyl fumarate

Y Kita, T Naka, M Imanishi, S Akai, Y Takebe, M Matsugi

CHEMICAL COMMUNICATIONS　No. 11　p. 1183-1184　1998/06　Research paper (scientific journal)

An efficient synthesis of peri-hydroxy aromatic compounds: A strong base-induced [4+2]cycloaddition of 4-phenylthio-substituted homophthalic anhydrides with various sulfinyl-substituted dienophiles

Y Kita, K Iio, A Okajima, Y Takeda, K Kawaguchi, BA Whelan, S Akai

SYNLETT　No. 3　p. 292-294　1998/03　Research paper (scientific journal)

Practical radical additions under mild conditions using 2,2′-azobis(2,4-dimethyl-4-methoxyvaleronitrile) [V-70] as an initiator

Yasuyuki Kita, Kentoku Gotanda, Kenji Murata, Miki Suemura, Atsunori Sano, Takahiro Yamaguchi, Masahisa Oka, Masato Matsugi

Organic Process Research and Development　Vol. 2　No. 4　p. 250-254　1998　Research paper (scientific journal)

Studies on Asymmetric Total Synthesis of Antitumor Antibiotic, Fredericamycin A.

Yasuyuki Kita, Shuji Akai, Hiromichi Fujioka

Journal of Synthetic Organic Chemistry, Japan　Vol. 56　No. 11　p. 963-974　1998　Research paper (scientific journal)

A highly stereoselective synthesis of alpha-linked C-glycopyranosides using 2,2'-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (V-70)

Y Kita, K Gotanda, A Sano, M Oka, K Murata, M Suemura, M Matsugi

TETRAHEDRON LETTERS　Vol. 38　No. 48　p. 8345-8348　1997/12　Research paper (scientific journal)

Isolation of the Quinone Mono O,S-Acetal Intermediates of the Aromatic Pummerer-Type Rearrangement of p-Sulfinytpnenols with 1-Ethoxyvinyl Esters

Yasuyuki Kita, Yoshifumi Takeda, Masato Matsugi, Kiyosei Iio, Kentoku Gotanda, Kenji Murata, Shuji Akai

Angewandte Chemie (International Edition in English)　Vol. 36　p. 1529-1531　1997/12/01

An efficient p-thiocyanation of phenols and naphthols using a reagent combination of phenyliodine dichloride and lead(II) thiocyanate

Y Kita, Y Takeda, T Okuno, M Egi, K Iio, K Kawaguchi, S Akai

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 45　No. 12　p. 1887-1890　1997/12　Research paper (scientific journal)

Novel ipso-substitution of p-sulfinylphenols through the Pummerer-type reaction: A selective and efficient synthesis of p-quinones and protected p-dihydroquinones

S Akai, Y Takeda, K Iio, K Takahashi, N Fukuda, Y Kita

JOURNAL OF ORGANIC CHEMISTRY　Vol. 62　No. 16　p. 5526-5536　1997/08

Acid-promoted rearrangement of cyclic alpha,beta-epoxy acylates: Stereoselective synthesis of spirocyclanes and quaternary carbon centers

Y Kita, S Kitagaki, Y Yoshida, S Mihara, DF Fang, M Kondo, S Okamoto, R Imai, S Akai, H Fujioka

JOURNAL OF ORGANIC CHEMISTRY　Vol. 62　No. 15　p. 4991-4997　1997/07　Research paper (scientific journal)

Reaction of silylketones with carbanions: Simple preparation of alpha-silylketones using organocerium reagents

S Akai, S Kitagaki, S Matsuda, Y Tsuzuki, T Naka, Y Kita

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 45　No. 7　p. 1135-1139　1997/07　Research paper (scientific journal)

Enzyme-catalyzed asymmetrization of 2,2-disubstituted 1,3-propanediols using 1-ethoxyvinyl esters

S Akai, T Naka, Y Takebe, Y Kita

TETRAHEDRON LETTERS　Vol. 38　No. 24　p. 4243-4246　1997/06　Research paper (scientific journal)

Oxidative intramolecular [4+2]cycloaddition of o-[(omega-phenylthioethynyl)acyl]phenols followed by the aromatic Pummerer-type reaction: A novel preparation of the peri-hydroxy dihydroquinone structure

S Akai, K Iio, Y Takeda, H Ueno, Y Kita

SYNLETT　No. 3　p. 310-312　1997/03　Research paper (scientific journal)

A novel efficient sulfenylation method using quinone mono-O,S-acetals under mild conditions

Masato Matsugi, Kentoku Gotanda, Kenji Murata, Yasuyuki Kita

Chemical Communications　No. 15　p. 1387-1388　1997　Research paper (scientific journal)

An efficient preparation of peri-hydroxy dihydroquinone derivatives through a pummerer-type rearrangement of silylene-protected peri-hydroxy aromatic sulfoxides

Yasuyuki Kita, Yoshifumi Takeda, Kiyosei Iio, Kayoko Yokogawa, Kenji Takahashi, Shuji Akai

Tetrahedron Letters　Vol. 37　No. 42　p. 7545-7548　1996/10　Research paper (scientific journal)

1-Ethoxyvinyl acetate as a novel, highly reactive, and reliable acyl donor for enzymatic resolution of alcohols

Y Kita, Y Takebe, K Murata, T Naka, S Akai

TETRAHEDRON LETTERS　Vol. 37　No. 41　p. 7369-7372　1996/10　Research paper (scientific journal)

Reaction of ynolate anions derived from silylketenes with electrophiles: A facile preparation of silyl ynol ethers and functionalized silylketenes

S Akai, S Kitagaki, T Naka, K Yamamoto, Y Tsuzuki, K Matsumoto, Y Kita

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1　No. 14　p. 1705-1709　1996/07　Research paper (scientific journal)

Asymmetric synthesis of chiral spirocyclanes: A new route to the optically active spiro[cyclopentane-1,1'-indan]-2,5-dione system

Y Kita, S Kitagaki, R Imai, S Okamoto, S Mihara, Y Yoshida, S Akai, H Fujioka

TETRAHEDRON LETTERS　Vol. 37　No. 11　p. 1817-1820　1996/03　Research paper (scientific journal)

Preparation of novel cyclic hypervalent iodine(III) compounds having azido, cyano, and nitrato ligands

S Akai, T Okuno, M Egi, T Takada, H Tohma, Y Kita

HETEROCYCLES　Vol. 42　No. 1　p. 47-51　1996/01　Research paper (scientific journal)

Asymmetric synthesis of chiral spirocyclanes: Selective formation of 2-acyloxy-1-oxospiro[4.n]alkanes by regio- and stereoselective rearrangement of α,β-epoxy acylates in bicyclo[n.3.0]alkane systems

Hiromichi Fujioka, Shinji Kitagaki, Reiko Imai, Michinori Kondo, Sachi Okamoto, Yutaka Yoshida, Shuji Akai, Yasuyuki Kita

Tetrahedron Letters　Vol. 36　No. 18　p. 3219-3222　1995/05　Research paper (scientific journal)

An efficient synthesis of p-quinones utilizing a novel Pummerer-type rearrangement of p-sulfinylphenols

Shuji Akai, Yoshifumi Takeda, Kiyosei Iio, Yutaka Yoshida, Yasuyuki Kita

Journal of the Chemical Society, Chemical Communications　No. 10　p. 1013-1013　1995　Research paper (scientific journal)

Pummerer-type rearrangement on aromatic rings: an unprecedented ipso-substitution of the sulfinyl group of p-sulfinylphenyl ethers into oxygen functional groups leading to protected dihydroquinone derivatives

Shuji Akai, Kiyosei Iio, Yoshifumi Takeda, Hiroshi Ueno, Kayoko Yokogawa, Yasuyuki Kita

Journal of the Chemical Society, Chemical Communications　No. 22　p. 2319-2319　1995　Research paper (scientific journal)

Preparation of bis(arylthio)iodobenzene and reaction with 1-alkynes. A novel route to 1,2-bis(arylthio)alkenes

Yasuyuki Kita, Takayuki Okuno, Hirofumi Tohma, Shuji Akai, Keita Matsumoto

Tetrahedron Letters　Vol. 35　No. 17　p. 2717-2720　1994/04　Research paper (scientific journal)

Chemistry of Silylketenes: Simple Preparation of Silylallenes by the Reaction of Silylketenes with Phosphorus Ylides.

Yasuyuki KITA, Yasunori TSUZUKI, Shinji KITAGAKI, Shuji AKAI

Chemical and Pharmaceutical Bulletin　Vol. 42　No. 2　p. 233-236　1994　Research paper (scientific journal)

Oxidative intramolecular [4 + 2]cycloaddition of silylene-protected 2-pyridone derivatives—a short and efficient synthesis of the DEF-ring of fredericamycin A

Yasuyuki Kita, Hiroshi Ueno, Shinji Kitagaki, Kyoko Kobayashi, Kiyosei Lio, Shuji Akai

J. Chem. Soc., Chem. Commun.　No. 6　p. 701-702　1994　Research paper (scientific journal)

Synthesis of 2,5-dioxygenated pyrazine 4-oxides: total synthesis of a new inhibitor of superoxide anion generation, OPC-15161

Yasuyuki Kita, Shuji Akai, Hiromichi Fujioka, Yasumitsu Tamura, Hitoshi Tone, Youichi Taniguchi

Journal of the Chemical Society, Perkin Transactions 1　No. 7　p. 875-875　1994　Research paper (scientific journal)

An Effectivep-Thiocyanation of Phenols Using Phenyliodine Dichloride-Lead(II) Thiocyanate

Yasuyuki Kita, Takayuki Okuno, Masahiro Egi, Kiyosei Iio, Yoshifumi Takeda, Shuji Akai

Synlett　Vol. 1994　No. 12　p. 1039-1040　1994

Chemistry of silylketenes: A simple preparation of α-silyl-α-stannylacetic esters and their stereoselective reformatsky-type reaction with aldehydes or aldimines

Shuji Akai, Yasunori Tsuzuki, Satoshi Matsuda, Shinji Kitagaki, Yasuyuki Kita

Journal of the Chemical Society, Perkin Transactions 1　No. 21　p. 2813-2820　1992　Research paper (scientific journal)

syn-Selective Reformatsky-Type Reaction of α-Silyl-α-stannylacetic Esters with Aldehydes: Stereoselective Synthesis of (E)- and (Z)-α,β-Unsaturated Esters

S AKAI, Y TSUZUKI, S MATSUDA, S KITAGAKI, Y KITA

SYNLETT　No. 12　p. 911-912　1991/12

Total synthesis of a new inhibitor of superoxide anion generation, opc-15161

Yasuyuki Kita, Shuji Akai, Hiromichi Fujioka, Yasumitsu Tamura, Hitoshi Tone, Youichi Taniguchi

Tetrahedron Letters　Vol. 32　No. 42　p. 6019-6020　1991/10　Research paper (scientific journal)

Synthetic anthracyclines: Total synthesis of D-ring pyridine and pyrazine analogues of 11-deoxydaunomycin.

Yasuyuki KITA, Masayuki KIRIHARA, Yuji FUJII, Ryuichi OKUNAKA, Shuji AKAI, Hiroshi MAEDA, Yasumitsu TAMURA, Kin-o SHIMOOKA, Hirofumi OHISHI, Toshimasa ISHIDA

Chemical and Pharmaceutical Bulletin　Vol. 39　No. 4　p. 857-864　1991　Research paper (scientific journal)

Chemistry of Silylketene: A One-Pot Synthesis of α-Silyl Ketones

Yasuyuki Kita, Satoshi Matsuda, Shinji Kitagaki, Yasunori Tsuzuki, Shuji Akai

Synlett　Vol. 1991　No. 06　p. 401-402　1991

An effective and selective conjugate propargylation reaction of stannylallenes to .alpha.,.beta.-unsaturated carbonyl compounds and .alpha.-nitro olefins

Junichi Haruta, Koichi Nishi, Satoshi Matsuda, Shuji Akai, Yasumitsu Tamura, Yasuyuki Kita

The Journal of Organic Chemistry　Vol. 55　No. 16　p. 4853-4859　1990/08　Research paper (scientific journal)

An efficient synthesis of .alpha.-silylacetates having various types of functional groups in the molecules

Yasuyuki Kita, Junichi Sekihachi, Yoshikazu Hayashi, Yong Zhong Da, Miki Yamamoto, Shuji Akai

The Journal of Organic Chemistry　Vol. 55　No. 3　p. 1108-1112　1990/02　Research paper (scientific journal)

Synthetic anthracyclines: regiospecific total synthesis of a D-ring pyridine analogue of 11-deoxydaunomycin

Yasuyuki Kita, Masayuki Kirihara, Yuji Fujii, Ryuichi Okunaka, Shuji Akai, Hiroshi Maeda, Yasumitsu Tamura

Journal of the Chemical Society, Chemical Communications　No. 2　p. 136-138　1990　Research paper (scientific journal)

Synthetic anthracyclines: Regiospecific total synthesis of D-ring thiophene analogues of daunomycin.

Yasuyuki KITA, Masayuki KIRIHARA, Jun-ichi SEKIHACHI, Ryuichi OKUNAKA, Manabu SASHO, Shin-ichiro MOHRI, Takao HONDA, Shuji AKAI, Yasumitsu TAMURA, Kin-o SHIMOOKA

Chemical and Pharmaceutical Bulletin　Vol. 38　No. 7　p. 1836-1843　1990　Research paper (scientific journal)

(Trimethylsilyl)ethoxyacetylene. An Effective Reagent for Mild Dehydrative Condensation of Carboxylic Acids andH-Acidic Materials

Yasuyuki Kita, Shuji Akai, Miki Yamamoto, Miyako Taniguchi, Yasumitsu Tamura

Synthesis　Vol. 1989　No. 04　p. 334-337　1989

Total synthesis of 11-deoxyanthracyclines: 4-Demethoxy-11-deoxydaunomycin, 11-deoxydaunomycin, and their analogues.

YASUMITSU TAMURA, SHUJI AKAI, HISAKAZU KISHIMOTO, MANABU SASHO, MASAYUKI KIRIHARA, YASUYUKI KITA

Chemical and Pharmaceutical Bulletin　Vol. 36　No. 10　p. 3897-3914　1988　Research paper (scientific journal)

Alkene cyclisations of N-alkenyl-α-(methylsuiphinyl)acetamides and N-alkenyl-α-chloro-α-(methylthio)acetamides: novel synthesis of five-, six-, and seven-membered lactams

Hiroyuki Ishibashi, Masazumi Ikeda, Hiroshi Maeda, Ko-ichi Ishiyama, Minako Yoshida, Shuji Akai, Yasumitsu Tamura

J. Chem. Soc., Perkin Trans. 1　Vol. 1,1099-1105　p. 1099-1105　1987

An efficient, regiospecific synthesis of 4-demethoxydaunomycinone and daunomycinone.

YASUMITSU TAMURA, MANABU SASHO, SHUJI AKAI, HISAKAZU KISHIMOTO, JUN-ICHI SEKIHACHI, YASUYUKI KITA

Chemical and Pharmaceutical Bulletin　Vol. 35　No. 4　p. 1405-1412　1987　Research paper (scientific journal)

Total synthesis of a D-ring indole analogue of daunomycin

Yasumitsu Tamura, Masayuki Kirihara, Manabu Sasho, Shuji Akai, Jun-ichi Sekihachi, Ryuichi Okunaka, Yasuyuki Kita

Journal of the Chemical Society, Chemical Communications　No. 19　p. 1474-1474　1987　Research paper (scientific journal)

A new synthetic strategy for heteroanthracyclines: Total synthesis of D-ring thiophene analogs of daunomycin

Yasumitsu Tamura, Masayuki Kirihara, Jun-ichi Sekihachi, Ryuichi Okunaka, Shin-ichiro Mohri, Teruhisa Tsugoshi, Shuji Akai, Manabu Sasho, Yasuyuki Kita

Tetrahedron Letters　Vol. 28　No. 34　p. 3971-3974　1987/01　Research paper (scientific journal)

Practical total synthesis of 11-deoxydaunomycinone and the first total synthesis of 11-deoxydaunomycin

Yasumitsu Tamura, Shuji Akai, Hisakazu Kishimoto, Masayuki Kirihara, Manabu Sasho, Yasuyuki Kita

Tetrahedron Letters　Vol. 28　No. 39　p. 4583-4586　1987/01　Research paper (scientific journal)

Facile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl)ethoxyacetylene

Yasuyuki Kita, Shuji Akai, Naomi Ajimura, Mayumi Yoshigi, Teruhisa Tsugoshi, Hitoshi Yasuda, Yasumitsu Tamura

The Journal of Organic Chemistry　Vol. 51　No. 22　p. 4150-4158　1986/10　Research paper (scientific journal)

A highly convergent strategy for the synthesis of 4-demethoxydaunomycinone and daunohycinone: A novel synthesis of C4-acetoxylated homophthalic anhydrides

Yasumitsu Tamura, Manabu Sasho, Shuji Akai, Hisakazu Kishimoto, Jun-ichi Sekihachi, Yasuyuki Kita

Tetrahedron Letters　Vol. 27　No. 2　p. 195-198　1986/01　Research paper (scientific journal)

One-step synthesis of the erythrinane skeleton by acid-promoted double cyclization of N-(cyclohex-1-enyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-α-(methylsulphinyl)acetamide and its derivatives

Hiroyuki Ishibashi, Kazumi Sato, Masazumi Lkeda, Hiroshi Maeda, Shuji Akai, Yasumitsu Tamura

J. Chem. Soc., Perkin Trans. 1　p. 605-609　1985　Research paper (scientific journal)

Synthesis of the erythrinan skeleton by acid-promoted cyclization of N-(3-oxo-1-cyclohexen-1-yl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-.ALPHA.-(methylsulfinyl)acetamide.

HIROYUKI ISHIBASHI, SUZUMI HARADA, KAZUMI SATO, MASAZUMI IKEDA, SHUJI AKAI, YASUMITSU TAMURA

Chemical and Pharmaceutical Bulletin　Vol. 33　No. 12　p. 5278-5283　1985　Research paper (scientific journal)

A short and efficient synthesis of 11-deoxyanthracyclinones: strong base-induced cycloaddition of the suitably substituted tetrahydrohomophthalic anhydride

Y. Tamura, M. Sasho, H. Ohe, S. Akai, Y. Kita

Tetrahedron Letters　Vol. 26　No. 12　p. 1549-1552　1985　Research paper (scientific journal)

A mild and facile synthesis of carboxylic anhydrides

Y. Kita, S. Akai, M. Yoshigi, Y. Nakajima, H. Yasuda, Y. Tamura

Tetrahedron Letters　Vol. 25　No. 52　p. 6027-6030　1984/01　Research paper (scientific journal)

A brief and regiospecific synthesis of the late-stage intermediate to 11-deoxyanthracyclinones

Y. Tamura, S. Akai, M. Sasho, Y. Kita

Tetrahedron Letters　Vol. 25　No. 11　p. 1167-1170　1984　Research paper (scientific journal)

Anthracyclinone syntheses using strong base induced cycloaddition of homophthalic anhydrides and related compounds

Yasumitsu Tamura, Manabu Sasho, Shuji Akai, Akimori Wada, Yasuyuki Kita

Tetrahedron　Vol. 40　No. 22　p. 4539-4548　1984/01　Research paper (scientific journal)

Polar cycloaddition of α-acyl-α-chlorosulfides with alkynes. Novel one-step syntheses of furans and 2-furanones

H. Ishibashi, S. Akai, H.-D. Choi, H. Nakagawa, Y. Tamura

Tetrahedron Letters　Vol. 24　No. 36　p. 3877-3878　1983/01　Research paper (scientific journal)

Acid-catalyzed cyclizations of n-vinyl-α-sulfinylacetamides A novel synthetic approach to erythrinane

Y. Tamura, H. Maeda, S. Akai, H. Ishibashi

Tetrahedron Letters　Vol. 23　No. 21　p. 2209-2212　1982/01　Research paper (scientific journal)

Pummerer reaction intermediate as an initiating function for cationic olefin cyclization

Y. Tamura, H. Maeda, S. Akai, K. Ishiyama, H. Ishibashi

Tetrahedron Letters　Vol. 22　No. 43　p. 4301-4304　1981/01　Research paper (scientific journal)