Direct biomolecule discrimination in mixed samples using nanogap-based single-molecule electrical measurement

Jiho Ryu, Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi

Scientific Reports　Vol. 13　No. 1　2023/06/05　Research paper (scientific journal)

Bio-molecular Sensing for Medical Applications Based on Single Molecule Electrical Measurement by Nanodevices Towards Medical Applications

Takahito OHSHIRO

BUNSEKI KAGAKU　Vol. 72　No. 3　p. 87-95　2023/03/05　Research paper (scientific journal)

Quantitative Microscopic Observation of Base–Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting

Yusuke Takashima, Yuki Komoto, Takahito Ohshiro, Kazuhiko Nakatani, Masateru Taniguchi

Journal of the American Chemical Society　Vol. 145　No. 2　p. 1310-1318　2023/01/04　Research paper (scientific journal)

Direct observation of DNA alterations induced by a DNA disruptor

Takahito Ohshiro, Ayumu Asai, Masamitsu Konno, Mayuka Ohkawa, Yuki Komoto, Ken Ofusa, Hideshi Ishii, Masateru Taniguchi

Scientific Reports　Vol. 12　No. 1　2022/12　Research paper (scientific journal)

Review of the use of nanodevices to detect single molecules

Takahito Ohshiro, Masateru Taniguchi

Analytical Biochemistry　Vol. 654　p. 114645-114645　2022/10　Research paper (scientific journal)

Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma.

Ryota Chijimatsu, Shogo Kobayashi, Yu Takeda, Masatoshi Kitakaze, Shotaro Tatekawa, Yasuko Arao, Mika Nakayama, Naohiro Tachibana, Taku Saito, Daisuke Ennishi, Shuta Tomida, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Daisuke Okuzaki, Daisuke Motooka, Takahito Ohshiro, Masateru Taniguchi, Yutaka Suzuki, Kazuhiko Ogawa, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

iScience　Vol. 25　No. 8　p. 104659-104659　2022/08/19　Research paper (scientific journal)

Single‐Molecule Classification of Aspartic Acid and Leucine by Molecular Recognition through Hydrogen Bonding and Time‐Series Analysis

Jiho Ryu, Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi

Chemistry – An Asian Journal　Vol. 17　No. 13　2022/07　Research paper (scientific journal)

Nanodevices for Biological and Medical Applications: Development of Single-Molecule Electrical Measurement Method

Takahito Ohshiro

Applied Sciences　Vol. 12　No. 3　p. 1539-1539　2022/01/31　Research paper (scientific journal)

Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway

Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi

Nanomaterials　Vol. 11　No. 3　p. 784-784　2021/03/19　Research paper (scientific journal)

Development of Nanogap-gold electrode device Towards single-molecule identification of small second messengers

Nanomaterials　Vol. 11　2021/02　Research paper (scientific journal)

Classification from positive and unlabeled data based on likelihood invariance for measurement

Yoshida T, Washio T, Ohshiro T, Taniguchi M

Intelligent Data Analysis　Vol. 25　No. 1　p. 57-79　2021/01　Research paper (scientific journal)

Length discrimination of homo-oligomeric nucleic acids with single-molecule measurement

Komoto Y, Ohshiro T, Taniguchi M

Analytical Science　Vol. 37　p. 513-518　2021/01

Key aurophilic motif for robust quantum-tunneling-based characterization of a nucleoside analogue marker.

Takafumi Furuhata, Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi, Ryosuke Ueki, Shinsuke Sando

Chemical science　Vol. 11　No. 37　p. 10135-10142　2020/09/07　Research paper (scientific journal)

Single-Molecule Counting of Nucleotide by Electrophoresis with Nanofluid integrated nano-gap devices

Ohshiro T, Komoto Y, Taniguchi M

Micromachines　Vol. 11　2020/08　Research paper (scientific journal)

Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.

Yuki Komoto, Takahito Ohshiro, Takeshi Yoshida, Etsuko Tarusawa, Takeshi Yagi, Takashi Washio, Masateru Taniguchi

Scientific reports　Vol. 10　No. 1　p. 11244-11244　2020/07/09　Research paper (scientific journal)

Chemical-Labeling-Assisted Detection of Nucleobase Modifications by Quantum-Tunneling-Based Single-Molecule Sensing.

Takafumi Furuhata, Takahito Ohshiro, Yuichi Izuhara, Tomoaki Suzuki, Ryosuke Ueki, Masateru Taniguchi, Shinsuke Sando

Chembiochem : a European journal of chemical biology　Vol. 21　No. 3　p. 335-339　2020/02/03　Research paper (scientific journal)

Development of single-molecule detection and translocation control by electrophresis of nano-fluid towards bioplymer sequencing

Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi

21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017　p. 539-540　2020　Research paper (international conference proceedings)

Detection of an alcohol-associated cancer marker by single-molecule quantum sequencing

Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi

Chemical Communications　Vol. 56　No. 91　p. 14299-14302　2020　Research paper (scientific journal)

High-Precision Single-Molecule Identification Based on Single-Molecule Information within a Noisy Matrix

M.Taniguchi, T.Ohshiro, Y.Komoto, T.Takaai, T.Yoshida, T.Washio

J.Phys.Chem.C　Vol. 123　No. 25　p. 15867-15873　2019/06　Research paper (scientific journal)

Highly Conductive Nucleotide Analogue Facilitates Base-Calling in Quantum-Tunneling-Based DNA Sequencing.

Takafumi Furuhata, Takahito Ohshiro, Gaku Akimoto, Ryosuke Ueki, Masateru Taniguchi, Shinsuke Sando

ACS nano　Vol. 13　No. 5　p. 5028-5035　2019/05/28　Research paper (scientific journal)

Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution.

Takahito Ohshiro, Yuuki Komoto, Masamitsu Konno, Jun Koseki, Ayumu Asai, Hideshi Ishii, Masateru Taniguchi

Scientific reports　Vol. 9　No. 1　p. 3886-3886　2019/03/07　Research paper (scientific journal)

Single molecule electrical identification of epigenetic variations by nanofluid integrated nanogap devices

Takahito Ohshiro, Yuuki Komoto, Masamitsu Konno, Jun Koseki, Ayumu Asai, Hideshi Ishii, Masateru Taniguchi

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019　p. 188-189　2019　Research paper (international conference proceedings)

Quadrupole-electrode-integrated micropores for selective single-particle detections

Tomoki Hayashida, Takahito Ohshiro, Makusu Tsutsui, Masateru Taniguchi

2018 IEEE Electron Devices Technology and Manufacturing Conference, EDTM 2018 - Proceedings　p. 307-309　2018/07/26　Research paper (international conference proceedings)

Quantitative analysis of DNA with single-molecule sequencing

T.Ohshiro, M.Tsutsui, K.Yokota, M.Taniguchi

Sci.Rep.　Vol. 80　No. 1　p. 8517-1-8517-8　2018/06　Research paper (scientific journal)

Electrical Nucleotide Sensor Based on Synthetic Guanine-Receptor-Modified Electrodes

Takahito Ohshiro, Rajiv Kumar Verma, Kazumichi Yokota, Makusu Tsutsui, Sanjukta Mukherjee, Tomoji Kawai, Kazuhiko Nakatani, Masateru Taniguchi

ChemistrySelect　Vol. 3　No. 13　p. 3819-3824　2018/04/09　Research paper (scientific journal)

Development of a single molecular tunnel-current identification method for electrical genome sequencing

Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi

Materials Research Society Symposium Proceedings　Vol. 1724　p. 13-17　2015　Research paper (international conference proceedings)

Detection of post-translational modifications in single peptides using electron tunnelling currents

Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Masayuki Furuhashi, Masateru Taniguchi, Tomoji Kawai

NATURE NANOTECHNOLOGY　Vol. 9　No. 10　p. 835-840　2014/10　Research paper (scientific journal)

Nonequilibrium Ionic Response of Biased Mechanically Controllable Break Junction (MCBJ) Electrodes

Kentaro Doi, Makusu Tsutsui, Takahito Ohshiro, Chih-Chun Chien, Michael Zwolak, Masateru Taniguchi, Tomoji Kawai, Satoyuki Kawano, Massimiliano Di Ventra

JOURNAL OF PHYSICAL CHEMISTRY C　Vol. 118　No. 7　p. 3758-3765　2014/02　Research paper (scientific journal)

Development of a single-molecule electrical nucleotide identification method toward a cell transcriptome analysis

Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014　p. 1798-1801　2014　Research paper (international conference proceedings)

Theoretical study of non-equilibrium ionic response near electrode surface

K. Doi, M. Tsutsui, T. Ohshiro, M. Taniguchi, T. Kawai, M. Di Ventra, Satoyuki Kawano

IFMBE Proceedings　Vol. 43　p. 108-111　2014　Research paper (international conference proceedings)

Development of Single-Molecule Tunnel-Current based Nucleotide identification Method

Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai, Masateru Taniguchi

2014 IEEE INTERNATIONAL NANOELECTRONICS CONFERENCE (INEC)　2014　Research paper (international conference proceedings)

Embedded TiO2 waveguides for sensing nanofluorophores in a microfluidic channel

M.Furuhashi, M.Fujiwara, T.Ohshiro, K.Matsubara, M.Tsutsui, M.Taniguchi, S.Takeuchi, T.Kawai

Appl. Phys. Lett.　Vol. 101　No. 15　p. 153115-1-153115-4　2012/10　Research paper (scientific journal)

Single-Molecule Electrical Random Resequencing of DNA and RNA

Takahito Ohshiro, Kazuki Matsubara, Makusu Tsutsui, Masayuki Furuhashi, Masateru Taniguchi, Tomoji Kawai

SCIENTIFIC REPORTS　Vol. 2　2012/07　Research paper (scientific journal)

Development of gating nanopore towards single-biomolecule electrical identification

Yuta Sasaki, Takahito Ohshiro, Satoyuki Kawano, Masateru Taniguchi, Tomoji Kawai

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012　p. 650-652　2012　Research paper (international conference proceedings)

Fabrication of nanofluidics and nanopore using reactive-ion dry-etching with electron-beam baked resists

Takahito Ohshiro, Chie Hotehama, Kazuki Matsubara, Kazumi Konda, Hiroe Kowada, Sanae Murayama, Rie Yamada, Tomoyo Kawase, Masateru Taniguchi, Tomoji Kawai

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012　p. 1807-1809　2012　Research paper (international conference proceedings)

Nano-scale Reactive-Ion Dry-Etching with Electron-Beam-Baked Resist

Takahito Ohshiro, Chie Hotehama, Kazuki Matsubara, Kazumi Konda, Hiroe Kowada, Sanae Murayama, Rie Yamada, Tomoyo Kawase, Makusu Tsutsui, Masayuki Furuhashi, Masateru Taniguchi, Tomoji Kawai

2012 12TH IEEE CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)　2012　Research paper (international conference proceedings)

Microfabrication processes of defectless TiO2 waveguides for insertion of a micro fluidic channel

Masayuki Furuhashi, Takahito Ohshiro, Masateru Taniguchi, Tomoji Kawai

2012 12TH IEEE CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)　2012　Research paper (international conference proceedings)

Fabrication of Gating Nanopore Towards Single-Biomolecule Electrical Identification

Yuta Sasaki, Takahito Ohshiro, Satoyuki Kawano, Masateru Taniguchi, Tomoji Kawai

2012 12TH IEEE CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)　2012　Research paper (international conference proceedings)

Tunnel-Current based Single-Molecule Identification of DNA/RNA oligmer by using Nano-MCBJ

Takahito Ohshiro, Makusu Tsutsui, Masateru Taniguchi, Tomoji Kawai

2012 12TH IEEE CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)　2012　Research paper (international conference proceedings)

Development of microfabricated TiO2 channel waveguides

Masayuki Furuhashi, Masazumi Fujiwara, Takahito Ohshiro, Makusu Tsutsui, Kazuki Matsubara, Masateru Taniguchi, Shigeki Takeuchi, Tomoji Kawai

AIP ADVANCES　Vol. 1　No. 3　2011/09　Research paper (scientific journal)

Atomically controlled fabrications of subnanometer scale electrode gaps

Makusu Tsutsui, Takahito Ohshiro, Kazuki Matsubara, Masayuki Furuhashi, Masateru Taniguchi, Tomoji Kawai

JOURNAL OF APPLIED PHYSICS　Vol. 108　No. 6　2010/09　Research paper (scientific journal)