顔写真

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Minoshima Masafumi
蓑島　維文
Minoshima Masafumi
蓑島　維文
Institutional repository
Graduate School of Engineering　Division of Applied Chemistry, Associate Professor
Institutional repository

Research History 7

  1. 2022/05 - Present
    Osaka University　Graduate School of Engineering Division of Applied Chemistry

  2. 2020/04 - 2022/04
    Osaka University Graduate School of Engineering Division of Applied Chemistry　Assistant Professor

  3. 2016/04/01 - 2020/03/31
    Osaka University Graduate School of Engineering Division of Science and Biotechnology　Assistant Professor

  4. 2015/04/01 - 2016/03/31
    Osaka University Immunology Frontier Research Center　Assistant Professor

  5. 2012/04/01 - 2015/03/31
    Osaka University Institute for Academic Initiatives　Assistant Professor

  6. 2010/04 - 2012/03
    東京大学先端科学研究センター　特任助教

  7. 2008/04 - 2010/03
    Japan Society for the Promotion of Science

Education 2

  1. Kyoto University　Graduate School, Division of Natural Science　Division of Chemistry

    2005/04 - 2010/03

  2. Kyoto University　Faculty of Science

    2001/04 - 2005/03

Professional Memberships 7

  1. 日本生物物理学会

  2. 日本バイオイメージング学会

  3. 日本分子イメージング学会

  4. がん分子標的学会

  5. 日本化学会 生体機能関連化学部会

  6. 日本ケミカルバイオロジー学会

  7. 日本化学会

Research Areas 2

  1. Nanotechnology/Materials / Biochemistry /

  2. Nanotechnology/Materials / Chemical biology /

Awards 1

  1. 令和5年度大阪大学賞（若手研究部門）

    大阪大学　2023/11

Papers 64

  1. Light‐Activated Gene Expression System Using a Caging‐Group‐Free Photoactivatable Dye

    Tatsuki Nonomura, Masafumi Minoshima, Kazuya Kikuchi

    Angewandte Chemie International Edition　2024/10/23　Research paper (scientific journal)

    Publisher: Wiley

  2. Hybrid Small-Molecule/Protein Fluorescent Probes

    Masafumi Minoshima, Shahi Imam Reja, Ryu Hashimoto, Kohei Iijima, Kazuya Kikuchi

    Chemical Reviews　Vol. 124　No. 10　p. 6198-6270　2024/05/08　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  3. Elastic Polymer Coated Nanoparticles with Fast Clearance for 19F MR Imaging

    Yuki Konishi, Masafumi Minoshima, Kohei Fujihara, Takayuki Uchihashi, Kazuya Kikuchi

    Angewandte Chemie International Edition　Vol. 62　2023/08/28　Research paper (scientific journal)

    Publisher: Wiley

  4. Development of a Versatile Protein Labeling Tool for Live‐Cell Imaging Using Fluorescent β‐Lactamase Inhibitors

    Masafumi Minoshima, Taro Umeno, Kohei Kadooka, Margaux Roux, Namiko Yamada, Kazuya Kikuchi

    Angewandte Chemie International Edition　Vol. 62　No. 18　2023/03/27　Research paper (scientific journal)

    Publisher: Wiley

  5. Efficient visible/NIR light-driven uncaging of hydroxylated thiazole orange-based caged compounds in aqueous media

    Ryu Hashimoto, Masafumi Minoshima, Souhei Sakata, Fumihito Ono, Hirokazu Ishii, Yuki Watakabe, Tomomi Nemoto, Saeko Yanaka, Koichi Kato, Kazuya Kikuchi

    Chemical Science　Vol. 13　No. 25　p. 7462-7467　2022　Research paper (scientific journal)

    Publisher: Royal Society of Chemistry (RSC)

  6. Development of Off-On Switching 19F MRI Probes for Cathepsin K Activity Detection

    Yuki Konishi, Atsuya Okunishi, Fuminori Sugihara, Tatsuya Nakamura, Kazuki Akazawa, Masafumi Minoshima, Kazuya Kikuchi

    Bulletin of the Chemical Society of Japan　Vol. 94　p. 1690-1694　2021/04/27　Research paper (scientific journal)

    Publisher: The Chemical Society of Japan

  7. An Acid Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities

    Ryu Hashimoto, Masafumi Minoshima, Junichi Kikuta, Shinya Yari, Steven D. Bull, Masaru Ishii, Kazuya Kikuchi

    Angewandte Chemie International Edition　2020/08　Research paper (scientific journal)

    Publisher: Wiley

  8. A Photoactivatable Antagonist for Controlling CREB Dependent Gene Expression

    T. Imoto, M. Minoshima, T. Yokoyama, B. P. Emery, S. D. Bull, H. Bito, K. Kikuchi

    ACS Cent. Sci.　Vol. 6　No. 10　p. 1813-1818　2020/08　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  9. Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB Gene Expression

    Takuma Imoto, Akihiro Kawase, Masafumi Minoshima, Tatsushi Yokoyama, Haruhiko Bito, Kazuya Kikuchi

    Organic letters　Vol. 22　No. 1　p. 22-25　2019/12　Research paper (scientific journal)

  10. In vivo Multicolor Imaging with Fluorescent Probes Revealed the Dynamics and Function of Osteoclast Proton Pumps

    Masafumi Minoshima, Junichi Kikuta, Yuta Omori, Shigeto Seno, Riko Suehara, Hiroki Maeda, Hideo Matsuda, Masaru Ishii, Kazuya Kikuchi

    ACS Central Science　Vol. 5　No. 6　p. 1059-1066　2019/06　Research paper (scientific journal)

    Publisher:

  11. Perfluorocarbon-based 19F MRI Nanoprobes for In Vivo Multicolor Imaging

    Kazuki Akazawa, Fuminori Sugihara, Tatsuya Nakamura, Hisashi Matsushita, Hiroaki Mukai, Rena Akimoto, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

    Angewandte Chemie (International ed. in English)　Vol. 57　No. 51　p. 16742-16747　2018/12　Research paper (scientific journal)

  12. Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics.

    Kazuki Akazawa, Fuminori Sugihara, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

    Chemical communications (Cambridge, England)　Vol. 54　No. 83　p. 11785-11788　2018/10　Research paper (scientific journal)

  13. Intracellular Protein Labeling Probes for Multicolor Single-molecule Imaging of Immune Receptor-adaptor Molecular Dynamics

    Ryota Sato, Jun Kozuka, Masahiro Ueda, Reiko Mishima, Yutaro Kumagai, Akimasa Yoshimura, Masafumi Minoshima, Shin Mizukami, Kazuya Kikuchi

    Journal of the American Chemical Society　Vol. 139　p. 17397-17404　2017/11　Research paper (scientific journal)

  14. Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

    Yue Wu, Masafumi Minoshima, Kazuya Kikuchi

    Frontiers in Chemistry　Vol. 12　2024/06/12　Research paper (scientific journal)

    Publisher: Frontiers Media SA

  15. Recent advancements of fluorescent biosensors using semisynthetic probes

    Shahi Imam Reja, Masafumi Minoshima, Yuichiro Hori, Kazuya Kikuchi

    Biosensors and Bioelectronics　Vol. 247　p. 115862-115862　2024/03　Research paper (scientific journal)

    Publisher: Elsevier BV

  16. Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light‐Triggered DNA Recombination

    Ryu Hashimoto, Masafumi Minoshima, Kazuya Kikuchi

    ChemBioChem　Vol. 25　No. 4　2024/01/19　Research paper (scientific journal)

    Publisher: Wiley

  17. Activatable 19F MRI probe for detection of α-amylase activity

    Yuki Konishi, Yuya Otera, Masafumi Minoshima, Kazuya Kikuchi

    Chemistry Letters　Vol. 53　No. 1　2024/01/11　Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)

  18. JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors.

    Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii

    Inflammation and regeneration　Vol. 43　No. 1　p. 18-18　2023/03/03　Research paper (scientific journal)

  19. Hybrid, dual visible and near-infrared fluorescence emission of (6,5) Single-Walled Carbon Nanotubes modified with fluorescein through aryl diazonium salt chemistry

    Mateusz Michał Tomczyk, Masafumi Minoshima, Kazuya Kikuchi, Agata Blacha-Grzechnik, Zbigniew Starosolski, Rohan Bhavane, Mariusz Zalewski, Nikodem Kuznik (Kuźnik)

    Nanotechnology　2022/10/21　Research paper (scientific journal)

    Publisher: IOP Publishing

  20. Photoinitiator‐Free Two‐Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication

    Atsushi Nakayama, Yasuaki Kumamoto, Masafumi Minoshima, Kazuya Kikuchi, Atsushi Taguchi, Katsumasa Fujita

    Advanced Optical Materials　p. 2200474-2200474　2022/07　Research paper (scientific journal)

    Publisher: Wiley

  21. pH‐Sensitive Polymethacrylates as Potential Contrast Agents in 19 F MRI

    Mariusz Zalewski, Dawid Janasik, Anna Kapała, Masafumi Minoshima, Fuminori Sugihara, Wojciech Raj, Joanna Pietrasik, Kazuya Kikuchi, Tomasz Krawczyk

    Macromolecular Chemistry and Physics　Vol. 223　No. 14　p. 2200027-2200027　2022/07　Research paper (scientific journal)

    Publisher: Wiley

  22. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

    Hiroyuki Tsukazaki, Junichi Kikuta, Tomoka Ao, Akito Morimoto, Chie Fukuda, Eisuke Tsuda, Masafumi Minoshima, Kazuya Kikuchi, Takashi Kaito, Masaru Ishii

    Bone　Vol. 152　p. 116095-116095　2021/11　Research paper (scientific journal)

    Publisher: Elsevier BV

  23. Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling

    Manuel Vicente, Jussep Salgado-Almario, Michelle M. Collins, Antonio Martínez-Sielva, Masafumi Minoshima, Kazuya Kikuchi, Beatriz Domingo, Juan Llopis

    Biomedicines　Vol. 9　No. 10　p. 1294-1294　2021/09/22　Research paper (scientific journal)

    Publisher: MDPI AG

  24. A step towards gadolinium-free bioresponsive MRI contrast agent

    Marzena Wyskocka-Gajda, Łukasz Przypis, Monika Olesiejuk, Tomasz Krawczyk, Anna Kuźnik, Krzysztof Nawara, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi, Nikodem Kuźnik

    European Journal of Medicinal Chemistry　Vol. 211　p. 113086-113086　2020/11　Research paper (scientific journal)

    Publisher: Elsevier BV

  25. Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T2 Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents.

    Tomczyk MM, Boncel S, Herman A, Krawczyk T, Jakóbik-Kolon A, Pawlyta M, Krzywiecki M, Chrobak A, Minoshima M, Sugihara F, Kikuchi K, Kuźnik N

    Int J Nanomedicine.　Vol. 2020　No. 15　p. 7433-7450　2020/10　Research paper (scientific journal)

    Publisher: Informa UK Limited

  26. Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain

    Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto

    JCI Insight　Vol. 5　No. 6　2020/03　Research paper (scientific journal)

    Publisher:

  27. Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages with Coumarin-Based Fluorescent Probes

    M. Weber, N. Yamada, X. Tian, S. D. Bull, M. Minoshima, K. Kikuchi, A. B. Mackenzie, T. D. James

    Front. Chem.　Vol. 8　No. 39　2020/02　Research paper (scientific journal)

    Publisher: Frontiers Media SA

  28. Dynamic Analyses of the Short-Term Effects of Different Bisphosphonates Using Intravital Two-Photon Microscopy.

    Junichi Kikuta, Mai Shirazaki, Takao Sudo, Hiroki Mizuno, Akito Morimoto, Riko Suehara, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii

    JBMR plus　Vol. 2　No. 6　p. 362-366　2018/11　Research paper (scientific journal)

  29. In vivo Visualization of Different Modes of Action of Biologic DMARDs Inhibiting Osteoclastic Bone Resorption

    Y. Matsuura, J. Kikuta, Y. Kishi, T. Hasegawa, D. Okuzaki, T. Hirano, M. Minoshima, K. Kikuchi, A. Kumanogoh, M. Ishii

    Ann. Rheum. Dis.　Vol. 77　p. 1219-1225　2018/04　Research paper (scientific journal)

  30. Development of Fluorescent Probes for Bone Imaging in vivo -Fluorescent Probes for Intravital Imaging of Osteoclast Activity-

    Masafumi Minoshima, Kazuya Kikuchi

    2018/02

  31. Intracellular protein-labeling probes for multicolor single-molecule imaging of immune receptor-adaptor molecular dynamics

    Sato R, Kozuka J, Ueda M, Mishima R, Kumagai Y, Yoshimura A, Minoshima M, Mizukami S, Kikuchi K

    Journal of the American Chemical Society　Vol. 139　No. 48　p. 17397-17404　2017/11　Research paper (scientific journal)

    Publisher: ACS Publications

  32. Photostable and photoswitching fluorescent dyes for super-resolution imaging

    Masafumi Minoshima, Kazuya Kikuchi

    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY　Vol. 22　No. 5　p. 639-652　2017/07　Research paper (scientific journal)

  33. Photostable and photoswitching fluorescent dyes for super-resolution imaging

    Masafumi Minoshima, Kazuya Kikuchi

    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY　Vol. 22　No. 5　p. 1-14　2017/07　Research paper (scientific journal)

  34. Comparison of the antiviral effect of solid-state copper and silver compounds

    Masafumi Minoshima, Yue Lu, Takuto Kimura, Ryuichi Nakano, Hitoshi Ishiguro, Yoshinobu Kubota, Kazuhito Hashimoto, Kayano Sunada

    JOURNAL OF HAZARDOUS MATERIALS　Vol. 312　No. 15　p. 1-7　2016/07　Research paper (scientific journal)

  35. Modified polysaccharides as potential F-19 magnetic resonance contrast agents

    Tomasz Krawczyk, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi

    CARBOHYDRATE RESEARCH　Vol. 428　p. 72-78　2016/06　Research paper (scientific journal)

  36. Chemical Tools for Probing Histone Deacetylase (HDAC) Activity

    Masafumi Minoshima, Kazuya Kikuchi

    ANALYTICAL SCIENCES　Vol. 31　No. 4　p. 287-292　2015/04

  37. Development of a Fluorogenic Probe Based on a DNA Staining Dye for Continuous Monitoring of the Histone Deacetylase Reaction

    Masafumi Minoshima, Tetsuaki Matsumoto, Kazuya Kikuchi

    ANALYTICAL CHEMISTRY　Vol. 86　No. 15　p. 7925-7930　2014/08　Research paper (scientific journal)

  38. Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA

    Wataru Kameshima, Takumi Ishizuka, Masafumi Minoshima, Makoto Yamamoto, Hiroshi Sugiyama, Yan Xu, Makoto Komiyama

    Angewandte Chemie - International Edition　Vol. 52　No. 51　p. 13681-13684　2013/12/16　Research paper (scientific journal)

  39. Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds

    Kayano Sunada, Masafumi Minoshima, Kazuhito Hashimoto

    JOURNAL OF HAZARDOUS MATERIALS　Vol. 235　p. 265-270　2012/10　Research paper (scientific journal)

  40. Photocatalytic inactivation of influenza virus by titanium dioxide thin film

    Ryuichi Nakano, Hitoshi Ishiguro, Yanyan Yao, Jitsuo Kajioka, Akira Fujishima, Kayano Sunada, Masafumi Minoshima, Kazuhito Hashimoto, Yoshinobu Kubota

    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES　Vol. 11　No. 8　p. 1293-1298　2012　Research paper (scientific journal)

  41. Hybrid CuxO/TiO2 Nanocomposites As Risk-Reduction Materials in Indoor Environments

    Xiaoqing Qiu, Masahiro Miyauchi, Kayano Sunada, Masafumi Minoshima, Min Liu, Yue Lu, Ding Li, Yoshiki Shimodaira, Yasuhiro Hosogi, Yasushi Kuroda, Kazuhito Hashimoto

    ACS NANO　Vol. 6　No. 2　p. 1609-1618　2011/12　Research paper (scientific journal)

  42. DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization

    Ai Yasuda, Kohji Noguchi, Masafumi Minoshima, Gengo Kashiwazaki, Teru Kanda, Kazuhiro Katayama, Junko Mitsuhashi, Toshikazu Bando, Hiroshi Sugiyama, Yoshikazu Sugimoto

    CANCER SCIENCE　Vol. 102　No. 12　p. 2221-2230　2011/12　Research paper (scientific journal)

  43. Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts

    Ganesh N. Pandian, Ken-ichi Shinohara, Akimichi Ohtsuki, Yusuke Nakano, Minoshima Masafumi, Toshikazu Bando, Hiroki Nagase, Yasuhiro Yamada, Akira Watanabe, Naohiro Terada, Shinsuke Sato, Hironobu Morinaga, Hiroshi Sugiyama

    CHEMBIOCHEM　Vol. 12　No. 18　p. 2822-2828　2011/12　Research paper (scientific journal)

  44. Photocatalytic inactivation of bacteriophages by TiO2-coated glass plates under low-intensity, long-wavelength UV irradiation

    Hitoshi Ishiguro, Ryuichi Nakano, Yanyan Yao, Jitsuo Kajioka, Akira Fujishima, Kayano Sunada, Masafumi Minoshima, Kazuhito Hashimoto, Yoshinobu Kubota

    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES　Vol. 10　No. 11　p. 1825-1829　2011　Research paper (scientific journal)

  45. Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates

    Gengo Kashiwazaki, Toshikazu Bando, Ken-ichi Shinohara, Masafumi Minoshima, Hana Kumamoto, Shigeki Nishijima, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 18　No. 8　p. 2887-2893　2010/04　Research paper (scientific journal)

  46. Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI

    Masafumi Minoshima, Toshikazu Bando, Ken-ichi Shinohara, Gengo Kashiwazaki, Shigeki Nishijima, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 18　No. 3　p. 1236-1243　2010/02　Research paper (scientific journal)

  47. Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes

    Masafumi Minoshima, James C. Chou, Sophie Lefebvre, Toshikazu Bando, Ken-ichi Shinohara, Joel M. Gottesfeld, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 18　No. 1　p. 168-174　2010/01　Research paper (scientific journal)

  48. Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content

    Shigeki Nishijima, Ken-ichi Shinohara, Toshikazu Bando, Masafumi Minoshima, Gengo Kashiwazaki, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 18　No. 2　p. 978-983　2010/01　Research paper (scientific journal)

  49. Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

    Hiroshi Tanaka, Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyama, Takashi Takahashi

    CHEMICAL COMMUNICATIONS　Vol. 46　No. 32　p. 5942-5944　2010　Research paper (scientific journal)

  50. Synthesis and properties of PI polyamide-SAHA conjugate

    Akimichi Ohtsuki, Makoto T. Kimura, Masafumi Minoshima, Tsukasa Suzuki, Maki Ikeda, Toshikazu Bando, Hiroki Nagase, Ken-ichi Shinohara, Hiroshi Sugiyama

    TETRAHEDRON LETTERS　Vol. 50　No. 52　p. 7288-7292　2009/12　Research paper (scientific journal)

  51. Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design

    Gengo Kashiwazaki, Toshikazu Bando, Ken-ichi Shinohara, Masafumi Minoshima, Shigeki Nishijima, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 17　No. 3　p. 1393-1397　2009/02　Research paper (scientific journal)

  52. Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe

    Jun Fujimoto, Toshikazu Bando, Masafumi Minoshima, Gengo Kashiwazaki, Shigeki Nishijima, Ken-ichi Shinohara, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 22　p. 9741-9744　2008/11　Research paper (scientific journal)

  53. Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers

    Jun Fujimoto, Toshikazu Bando, Masafumi Minoshima, Shinsuke Uchida, Makoto Iwasaki, Ken-ichi Shinohara, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 11　p. 5899-5907　2008/06　Research paper (scientific journal)

  54. Pyrrole-imidazole hairpin polyamides with high affinity at 5CGCG3 DNA sequence; influence of cytosine methylation on binding

    Masafumi Minoshima, Toshikazu Bando, Shunta Sasaki, Jun Fujimoto, Hiroshi Sugiyama

    NUCLEIC ACIDS RESEARCH　Vol. 36　No. 9　p. 2889-2894　2008/05　Research paper (scientific journal)

  55. Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition

    Toshikazu Bando, Masafumi Minoshima, Gengo Kashiwazaki, Ken-ichi Shinohara, Shunta Sasaki, Akimichi Ohtsuki, Masataka Murakami, Satomi Nakazono, Hiroshi Suglyarna, Jun Fujimoto

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 5　p. 2286-2291　2008/03　Research paper (scientific journal)

  56. Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides

    Shunta Sasaki, Toshikazu Bando, Masafumi Minoshima, Ken-ichi Shinohara, Hiroshi Sugiyama

    CHEMISTRY-A EUROPEAN JOURNAL　Vol. 14　No. 3　p. 864-870　2008　Research paper (scientific journal)

  57. Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides

    Toshikazu Bando, Jun Fujimoto, Masafumi Minoshima, Ken-ichi Shinohara, Shunta Sasaki, Gengo Kashiwazaki, Masatoshi Mizumura, Hiroshi Sugiyama

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 15　No. 22　p. 6937-6942　2007/11　Research paper (scientific journal)

  58. DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation

    Masafumi Minoshima, Toshikazu Bando, Shunta Sasaki, Ken-ichi Shinohara, Tatsuhiko Shimizu, Jun Fujimoto, Hiroshi Sugiyama

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 129　No. 17　p. 5384-5390　2007/05　Research paper (scientific journal)

  59. Sequence-specific alkylation by a tandem motif of pyrrole-imidazole CBI conjugate.

    Sasaki S, Minoshima M, Fujimoto J, Shinohara K, Bando T, Sugiyama H

    Nucleic acids symposium series (2004)　No. 51　p. 265-266　2007

  60. Base pair recognition of the stereochemically alpha-substituted gamma-turn of pyrrole/imidazole hairpin polyamides

    Wen Zhang, Masafumi Minoshima, Hiroshi Sugiyama

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 128　No. 46　p. 14905-14912　2006/11　Research paper (scientific journal)

  61. Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers

    Shunta Sasaki, Toshikazu Bando, Masafumi Minoshima, Tatsuhiko Shimizu, Ken-ichi Shinohara, Toshiyasu Takaoka, Hiroshi Sugiyama

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 128　No. 37　p. 12162-12168　2006/09　Research paper (scientific journal)

  62. Efficient DNA alkylation by a pyrrole-imidazole cbi conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition

    Toshikazu Bando, Shunta Sasaki, Masafumi Minoshima, Chikara Dohno, Ken-Ichi Shinohara, Akihiko Narita, Hiroshi Sugiyama

    Bioconjugate Chemistry　Vol. 17　No. 3　p. 715-720　2006/05　Research paper (scientific journal)

  63. Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker

    Ken-Ichi Shinohara, Toshikazu Bando, Shunta Sasaki, Yogo Sakakibara, Masafum Minoshima, Hiroshi Sugiyama

    Cancer Science　Vol. 97　No. 3　p. 219-225　2006/03　Research paper (scientific journal)

  64. Alkylation of template strand of coding region causes effective gene silencing

    Ken-Ichi Shinohara, Shunta Sasaki, Masafumi Minoshima, Toshikazu Bando, Hiroshi Sugiyama

    Nucleic Acids Research　Vol. 34　No. 4　p. 1189-1195　2006/03　Research paper (scientific journal)

Misc. 15

  1. Near-infrared fluorescent probes: a next-generation tool for protein-labeling applications

    Shahi Imam Reja, Masafumi Minoshima, Yuichiro Hori, Kazuya Kikuchi

    Chemical Science　Vol. 12　No. 10　p. 3437-3447　2020/10　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: Royal Society of Chemistry (RSC)

  2. Recent advances in activatable 19F MR Imaging nano‐probes for the detection of biomarkers

    Jeremy Salaam, Masafumi Minoshima, Kazuya Kikuchi

    Analysis & Sensing　2022/10/07　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: Wiley

  3. 新規可逆結合型タグ蛍光プローブの1分子イメージングへの応用

    粟津 利邦, 簑島 維文, Shahi Imam Reja, 神原 丈敏, 菊地 和也, 岡田 康志

    Vol. 72回　p. 3-2　2020/06/01　Research paper, summary (national, other academic conference)

    Publisher: (一社)日本細胞生物学会

  4. Development of an effective protein-labeling system based on smart fluorogenic probes.

    Reja SI, Minoshima M, Hori Y, Kikuchi K

    J. Biol. Inorg. Chem.　Vol. 24　No. 4　p. 443-455　2019/06　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: Springer Science and Business Media LLC

  5. 光触媒による感染リスク低減の検討(第3報) 銅化合物複合酸化チタン光触媒による抗菌効果の実フィールド検証

    絹川 謙作, 山本 晃士, 三木 慎一郎, 砂田 香矢乃, 蓑島 維文, 石黒 斉, 姚 燕燕, 中野 竜一, 笹原 武志, 梶岡 実雄, 窪田 吉信, 橋本 和仁

    日本環境感染学会誌　Vol. 27　No. Suppl.　p. 141-141　2012/01

    Publisher: (一社)日本環境感染学会

  6. 光触媒による感染リスク低減の検討(第4報) バクテリオファージを含む飛沫核に対する銅化合物複合酸化チタンの抗ウイルス効果

    三木 慎一郎, 山本 晃士, 絹川 謙作, 砂田 香矢乃, 蓑島 維文, 石黒 斉, 姚 燕燕, 中野 竜一, 笹原 武志, 梶岡 実雄, 窪田 吉信, 橋本 和仁

    日本環境感染学会誌　Vol. 27　No. Suppl.　p. 141-141　2012/01

    Publisher: (一社)日本環境感染学会

  7. 光触媒による感染リスク低減の検討(第1報) 銅化合物複合酸化チタン光触媒による細菌及びウイルスに対する効果

    石黒 斉, 姚 燕燕, 中野 竜一, 三木 慎一郎, 絹川 謙作, 山本 晃士, 砂田 香矢乃, 蓑島 維文, 梶岡 実雄, 橋本 和仁, 窪田 吉信

    日本環境感染学会誌　Vol. 27　No. Suppl.　p. 246-246　2012/01

    Publisher: (一社)日本環境感染学会

  8. 光触媒による感染リスク低減の検討(第2報) 院内から分離される環境菌の調査

    中野 竜一, 石黒 斉, 姚 燕燕, 絹川 謙作, 山本 晃士, 三木 慎一郎, 砂田 香矢乃, 蓑島 維文, 笹原 武志, 梶岡 実雄, 橋本 和仁, 窪田 吉信

    日本環境感染学会誌　Vol. 27　No. Suppl.　p. 317-317　2012/01

    Publisher: (一社)日本環境感染学会

  9. PNA-ポリアミド複合体による二本鎖DNAの所定位置の認識

    亀島渡, 石塚匠, 蓑島維文, XU Yan, 杉山弘, 小宮山眞

    日本化学会講演予稿集　Vol. 90th　No. 3　2010

  10. Molecular design of sequence specific DNA alkylating agents.

    M. Minoshima, T. Bando, K. Shinohara, H. Sugiyama

    Nucleic acids symposium series (2004)　No. 53　p. 69-70　2009

  11. Targeting specific gene by alkylating pyrrole-imidazole polyamides.

    M. Minoshima, J. Chou, S. Lefebvre, T. Bando, K. Shinohara, J.M. Gottesfeld, H. Sugiyama

    Nucleic acids symposium series (2004)　No. 52　p. 363-364　2008

  12. Synthesis and biological properties of pyrrole-imidazole polyamide conjugates.

    Minoshima M, Sasaki S, Fujimoto J, Shinohara K, Bando T, Sugiyama H

    Nucleic acids symposium series (2004)　No. 51　p. 35-36　2007

  13. Synthesis and evaluation of sequence-specific DNA alkylating agents: effect of alkylation subunits.

    Shimizu T, Sasaki S, Minoshima M, Shinohara K, Bando T, Sugiyama H

    Nucleic acids symposium series (2004)　No. 50　p. 155-156　2006

  14. Molecular design of DNA alkylating pyrrole-imidazole polyamides with longer recognition sequence.

    Minoshima M, Sasaki S, Shinohara K, Shimizu T, Bando T, Sugiyama H

    Nucleic acids symposium series (2004)　No. 50　p. 165-166　2006

  15. The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides.

    S. Sasaki, M. Minoshima, T. Shimizu, J. Fujimoto, K. Shinohara, T. Bando, H. Sugiyama

    Nucleic acids symposium series (2004)　No. 50　p. 111-112　2006

Publications 5

  1. Fluorine Magnetic Resonance Imaging

    Masafumi Minoshima, Yuki Konishi, Yue Wu, Kazuya Kikuchi

    Taylor & Francis group　2024

  2. 核酸科学ハンドブック 第5章2 MRIプローブ

    蓑島維文, 菊地和也

    講談社サイエンティフィク　2020/12　Scholarly book

    ISBN: 9784065207864

  3. 発光イメージング実験ガイド「機能性セレンテラジンを用いた発光検出」

    蓑島維文, 菊地和也

    羊土社　2019/09　Textbook, survey, introduction

    ISBN: 4758122407

  4. Chemical Tools for Elucidation of Epigenetic Mechanisms

    M. Minoshima, K. Kikuchi

    Inperial College Press　2016/09　Scholarly book

    ISBN: 9781783269600

  5. 固体銅一価化合物が示す抗ウィルス・抗菌メカニズム

    蓑島維文, 橋本和仁

    可視光応答型半導体光触媒　2012/02　Scholarly book

    ISBN: 9784907837235

Presentations 4

  1. Optochemical Gene Expression System Using Caging-Group-Free Photoactivatable Dye

    Masafumi Minoshima

    FASEB conference: Optical Probes　2025/07/23

  2. 時間無制限蛍光イメージングに向けた交換可能なタンパク質標識法の開発

    蓑島 維文

    日本顕微鏡学会第80回学術講演会　2024/06/04

  3. Development of 19F Magnetic Resonance Imaging Probe for in vivo Sensing Biomarkers

    Masafumi Minoshima

    ASBIC10　2022/11/30

  4. Development of Optochemical Tools for Regulation of CREB-Dependent Transcriptional Activity

    Masafumi Minoshima, Takuma Imoto, Akihiro Kawase, Kazuya Kikuchi

    Pacifichem 2021　2021/12/18

Industrial Property Rights 7

  1. 浄水器

    三木 慎一郎, 絹川 謙作, 山本 晃士, 橋本 和仁, 砂田 香矢乃, 蓑島 維文, 宮内 雅浩

    特許第5815966号

    出願日:2011/03

    登録日:2015/10

  2. 空気清浄機

    三木 慎一郎, 絹川 謙作, 山本 晃士, 橋本 和仁, 砂田 香矢乃, 蓑島 維文, 宮内 雅浩

    特許第5690186号

    出願日:2011/03

    登録日:2015/10

  3. タンパク質間相互作用を可視化する手法

    蓑島維文, Li Jiatong, 菊地和也

    出願日:2024/03/01

  4. タンパク質を蛍光標識する手法

    蓑島維文, 飯嶋航平, レジャ シャヒ イマーム, 菊地和也

    出願日:2023/03/06

  5. ケージド化合物から化合物を放出させる方法

    蓑島 維文, 橋本 龍, 菊地 和也

    出願日:2021/02

  6. 撥水性光触媒組成物及び撥水性光触媒塗膜

    山科 大悟, 野間 真二郎, 植田 剛士, 三木 慎一郎, 橋本 和仁, 砂田 香矢乃, 蓑島 維文, 宮内 雅浩

    出願日:2011/03

  7. 水処理材及び水処理装置

    絹川 謙作, 三木 慎一郎, 井 千尋, 橋本 和仁, 砂田 香矢乃, 蓑島 維文

    出願日:2011/03

Institutional Repository 4

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Light-Activated Gene Expression System Using a Caging-Group-Free Photoactivatable Dye

    Nonomura Tatsuki, Minoshima Masafumi, Kikuchi Kazuya

    Angewandte Chemie - International Edition　Vol. 64　No. 4　2024/11/06

  2. Development of elliptic core-shell nanoparticles with fluorinated surfactants for ¹⁹F MRI

    Wu Yue, Minoshima Masafumi, Kikuchi Kazuya

    Frontiers in Chemistry　Vol. 12　2024/06/12

  3. JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

    Yari Shinya, Kikuta Junichi, Shigyo Hotaka, Miyamoto Yu, Okuzaki Daisuke, Furusawa Yuki, Minoshima Masafumi, Kikuchi Kazuya, Ishii Masaru

    Inflammation and Regeneration　Vol. 43　No. 1　2023/03/03

  4. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

    Tsukazaki Hiroyuki, Kikuta Junichi, Ao Tomoka, Morimoto Akito, Fukuda Chie, Tsuda Eisuke, Minoshima Masafumi, Kikuchi Kazuya, Kaito Takashi, Ishii Masaru

    Bone　Vol. 152　2021/11/01