TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8+ T細胞の分類と解析

永田 暁教, 藤木 文博, 森本 創世子, 中田 潤, 西田 純幸, 中島 博子, 橋井 佳子, 坪井 昭博, 岡 芳弘, 尾路 祐介, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 27回　p. 122-122　2023/06

Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs.

Fumihiro Fujiki, Soyoko Morimoto, Yuya Nishida, Satoe Tanii, Nao Aoyama, Miki Inatome, Kento Inoue, Akiko Katsuhara, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 72　No. 7　p. 2347-2356　2023/03/20　Research paper (scientific journal)

Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia.

Hikaru Minagawa, Yoshiko Hashii, Hiroko Nakajima, Fumihiro Fujiki, Soyoko Morimoto, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Akihiro Tsuboi, Keiichi Ozono

BMC cancer　Vol. 23　No. 1　p. 167-167　2023/02/20　Research paper (scientific journal)

WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1

Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, Motoyuki Suzuki, Sumiyuki Nishida, Jun Nakata, Akihiro Tsuboi, Miki Iwai, Sae Hayashi, Rin Imanishi, Sayaka Ikejima, Mizuki Kanegae, Masahiro Iwamoto, Mayu Ikeda, Kento Yagi, Haruka Shimokado, Hiroko Nakajima, Kana Hasegawa, Soyoko Morimoto, Fumihiro Fujiki, Akira Nagahara, Atsushi Tanemura, Yutaka Ueda, Tsunekazu Mizushima, Masato Ohmi, Takayuki Ishida, Manabu Fujimoto, Norio Nonomura, Tadashi Kimura, Hidenori Inohara, Seiji Okada, Haruhiko Kishima, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Haruo Sugiyama

Cancers　Vol. 15　No. 2　p. 393-393　2023/01/06　Research paper (scientific journal)

GEM併用WT1ワクチン投与膵癌患者からのWT1^126特異的high-avidity TCRの単離

森本 創世子, 藤木 文博, 西田 純幸, 永田 暁教, 中田 潤, 中島 博子, 尾路 祐介, 岡 芳弘, 杉山 治夫

日本臨床免疫学会総会プログラム・抄録集　Vol. 50回　p. 112-112　2022/10

An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia.

Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Kiyoshi Takeda, Akihiro Tsuboi, Keiichi Ozono

Cancer immunology, immunotherapy : CII　2022/06/14　Research paper (scientific journal)

WT1蛋白を標的とした小児固形腫瘍に対するがん免疫療法 予後と免疫学的解析

橋井 佳子, 細谷 要介, 岡 芳弘, 尾路 祐介, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 鐘ヶ江 瑞稀, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 26回　p. 140-140　2022/06

Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Akie Iehara, Mai Iwai, Seishin Hashiguchi, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Satoshi Yoshihara, Masahiro Manabe, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Takafumi Nakao, Asao Hirose, Masayuki Hino, Shiho Ueda, Katsuto Takenaka, Takashi Masuko, Koichi Akashi, Takahiro Maruno, Susumu Uchiyama, Shinji Takamatsu, Naoki Wada, Eiichi Morii, Shushi Nagamori, Daisuke Motooka, Yoshikatsu Kanai, Yusuke Oji, Tomoyoshi Nakagawa, Noriyuki Kijima, Haruhiko Kishima, Atsuyo Ikeda, Takayuki Ogino, Yasushi Shintani, Tateki Kubo, Emiko Mihara, Kosuke Yusa, Haruo Sugiyama, Junichi Takagi, Eiji Miyoshi, Atsushi Kumanogoh, Naoki Hosen

Science translational medicine　Vol. 14　No. 632　2022/02/16　Research paper (scientific journal)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine.

Shouq Alzaaqi, Norifumi Naka, Kenichiro Hamada, Naoki Hosen, Mizuki Kanegae, Hidetatsu Outani, Mayuko Adachi, Rin Imanishi, Eiichi Morii, Miki Iwai, Jun Nakata, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Oncology letters　Vol. 23　No. 2　p. 65-65　2022/02　Research paper (scientific journal)

T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy.

Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Frontiers in immunology　Vol. 13　p. 935465-935465　2022　Research paper (scientific journal)

Cellular and Humoral Immune Responses Induced by an HLA Class I-restricted Peptide Cancer Vaccine Targeting WT1 Are Associated With Favorable Clinical Outcomes in Advanced Ovarian Cancer.

Sumiyuki Nishida, Soyoko Morimoto, Yusuke Oji, Satoshi Morita, Toshiaki Shirakata, Takayuki Enomoto, Akihiro Tsuboi, Yutaka Ueda, Kiyoshi Yoshino, Alzaaqi Shouq, Mizuki Kanegae, Satoshi Ohno, Fumihiro Fujiki, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Tadashi Kimura, Haruo Sugiyama

Journal of immunotherapy (Hagerstown, Md. : 1997)　Vol. 45　No. 1　p. 56-66　2022/01/01　Research paper (scientific journal)

難治性白血病に対する同種造血幹細胞移植後WT1ペプチドワクチン接種時の免疫応答の解析(WT1-targeteing immunotherapy after allogeneic HSCT in children with refractory acute leukemias)

橋井 佳子, 岡 芳弘, 坂田 尚己, 渡辺 新, 尾路 祐介, 保仙 直毅, 山本 紘司, 服部 聡, 中島 博子, 中田 潤, 藤木 文博, 森本 創世子, Alzaaqi Shouq, 池島 彩香, 西田 純幸, 大薗 恵一, 坪井 昭博, 杉山 治夫

日本血液学会学術集会　Vol. 83回　p. OS1-5　2021/09

Identification of mouse helper epitopes for WT1-specific CD4+ T cells.

Hiroko Nakajima, Jun Nakata, Kanako Imafuku, Hiromu Hayashibara, Kazuki Isokawa, Keiko Udaka, Fumihiro Fujiki, Soyoko Morimoto, Kana Hasegawa, Naoki Hosen, Yoshiko Hashii, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 11　p. 3323-3335　2021/07/16　Research paper (scientific journal)

WT1ヘルパーペプチド併用WT1ペプチドワクチン投与患者における異なる2つのWT1-tetramer+CD8+T細胞集団の同定

藤木 文博, 坪井 昭博, 森本 創世子, 橋本 直哉, 稲留 美希, 中島 博子, 中田 潤, 西田 純幸, 岡 芳弘, 尾路 祐介, 杉山 治夫

日本がん免疫学会総会プログラム・抄録集　Vol. 25回　p. 175-175　2021/05

Enhanced immune reaction resulting from co-vaccination of WT1 helper peptide assessed on PET-CT.

Jun Nakata, Kayako Isohashi, Soyoko Morimoto, Ryota Itou, Takashi Kamiya, Ai Matsuura, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Yoshiko Hasii, Kana Hasegawa, Shinichi Nakatsuka, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Atsushi Kumanogoh, Masaru Shibano, Satoru Munakata, Yusuke Oji, Jun Hatazawa, Haruo Sugiyama

Medicine　Vol. 99　No. 39　2020/09/25　Research paper (scientific journal)

Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.

Fumihiro Fujiki, Akihiro Tsuboi, Soyoko Morimoto, Naoya Hashimoto, Miki Inatome, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Kana Hasegawa, Naoki Hosen, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 70　No. 1　p. 253-263　2020/07/22　Research paper (scientific journal)

Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy.

Sae Hayashi, Rin Imanishi, Mayuko Adachi, Sayaka Ikejima, Jun Nakata, Soyoko Morimoto, Fumihiro Fujiki, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Hiroko Nakajima, Kana Hasegawa, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Biomedical reports　Vol. 12　No. 5　p. 244-250　2020/05　Research paper (scientific journal)

ペプチドワクチン癌免疫療法におけるReader-free ELISPOTアッセイ

今西 凛, 林 紗恵, 池島 彩香, 中田 潤, 森本 創世子, 藤木 文博, 杉山 治夫, 尾路 祐介

日本分子腫瘍マーカー研究会誌　Vol. 35　p. 37-38　2019/12

ペプチドワクチン癌免疫療法におけるReader-free ELISPOTアッセイ

今西 凛, 林 紗恵, 池島 彩香, 中田 潤, 森本 創世子, 藤木 文博, 杉山 治夫, 尾路 祐介

日本分子腫瘍マーカー研究会プログラム・講演抄録　Vol. 39回　p. 78-79　2019/09

Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.

Sumiyuki Nishida, Akihiro Tsuboi, Atsushi Tanemura, Toshinori Ito, Hiroko Nakajima, Toshiaki Shirakata, Soyoko Morimoto, Fumihiro Fujiki, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Ichiro Kawase, Yoshihiro Oka, Ichiro Azuma, Satoshi Morita, Haruo Sugiyama

Medicine　Vol. 98　No. 33　2019/08　Research paper (scientific journal)

【血液領域における免疫療法と抗体医薬-最近の展開】急性骨髄性白血病に対するWT1ペプチドワクチンの有用性

中田 潤, 中江 吉希, 川上 学, 坪井 昭博, 森本 創世子, 中島 博子, 橋井 佳子, 藤木 文博, 西田 純幸, 長谷川 加奈, 保仙 毅, 尾路 祐介, 岡 芳弘, 杉山 治夫

血液内科　Vol. 79　No. 1　p. 19-25　2019/07

A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma.

Akihiro Tsuboi, Naoya Hashimoto, Fumihiro Fujiki, Soyoko Morimoto, Naoki Kagawa, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Satoshi Morita, Junichi Sakamoto, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

Cancer immunology, immunotherapy : CII　Vol. 68　No. 2　p. 331-340　2019/02　Research paper (scientific journal)

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.

Jun Nakata, Hiroko Nakajima, Hiromu Hayashibara, Kanako Imafuku, Soyoko Morimoto, Fumihiro Fujiki, Daisuke Motooka, Daisuke Okuzaki, Kana Hasegawa, Naoki Hosen, Akihiro Tsuboi, Yoshihiro Oka, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama

Oncotarget　Vol. 9　No. 89　p. 36029-36038　2018/11/13　Research paper (scientific journal)

Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.

Soyoko Morimoto, Fumihiro Fujiki, Kenta Kondo, Hiroko Nakajima, Yoshiki Kobayashi, Miki Inatome, Nao Aoyama, Yuya Nishida, Akihiro Tsuboi, Yoshihiro Oka, Sumiyuki Nishida, Jun Nakata, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

Oncotarget　Vol. 9　No. 75　p. 34132-34141　2018/09/25　Research paper (scientific journal)

Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.

Jun Nakata, Yoshiki Nakae, Manabu Kawakami, Soyoko Morimoto, Daisuke Motooka, Naoki Hosen, Fumihiro Fujiki, Hiroko Nakajima, Kana Hasegawa, Sumiyuki Nishida, Akihiro Tsuboi, Yusuke Oji, Yoshihiro Oka, Atsushi Kumanogoh, Haruo Sugiyama

British journal of haematology　Vol. 182　No. 2　p. 287-290　2018/07

A versatile T cell-based assay to assess therapeutic antigenspecific PD-1-targeted approaches

Maarten Versteven, Johan M.J. Van den Bergh, Katrijn Broos, Fumihiro Fujiki, Diana Campillo-Davo, Hans De Reu, Soyoko Morimoto, Quentin Lecocq, Marleen Keyaerts, Zwi Berneman, Haruo Sugiyama, Viggo F.I. Van Tendeloo, Karine Breckpot, Eva Lion

Oncotarget　Vol. 9　No. 45　p. 27797-27808　2018/06/12　Research paper (scientific journal)

WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies.

Yusuke Oji, Masayoshi Inoue, Yoshito Takeda, Naoki Hosen, Yasushi Shintani, Manabu Kawakami, Takuya Harada, Yui Murakami, Miki Iwai, Mari Fukuda, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Toshiaki Shirakata, Hiroko Nakajima, Kana Hasegawa, Hiroshi Kida, Takashi Kijima, Soyoko Morimoto, Fumihiro Fujiki, Akihiro Tsuboi, Eiichi Morii, Satoshi Morita, Junichi Sakamoto, Atsushi Kumanogoh, Yoshihiro Oka, Meinoshin Okumura, Haruo Sugiyama

International journal of cancer　Vol. 142　No. 11　p. 2375-2382　2018/06/01　Research paper (scientific journal)

Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.

Sumiyuki Nishida, Takeshi Ishikawa, Shinichi Egawa, Shigeo Koido, Hiroaki Yanagimoto, Jun Ishii, Yoshihide Kanno, Satoshi Kokura, Hiroaki Yasuda, Mari Saito Oba, Maho Sato, Soyoko Morimoto, Fumihiro Fujiki, Hidetoshi Eguchi, Hiroaki Nagano, Atsushi Kumanogoh, Michiaki Unno, Masanori Kon, Hideaki Shimada, Kei Ito, Sadamu Homma, Yoshihiro Oka, Satoshi Morita, Haruo Sugiyama

Cancer immunology research　Vol. 6　No. 3　p. 320-331　2018/03　Research paper (scientific journal)

The activated conformation of integrin beta(7) is a novel multiple myeloma-specific target for CAR T cell therapy

Naoki Hosen, Yukiko Matsunaga, Kana Hasegawa, Hiroshi Matsuno, Yuki Nakamura, Mio Makita, Kouki Watanabe, Mikako Yoshida, Kei Satoh, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Masahiro Manabe, Hiroyoshi Ichihara, Yasutaka Aoyama, Atsuko Mugitani, Takafumi Nakao, Masayuki Hino, Ryosuke Uchibori, Keiya Ozawa, Yoshihiro Baba, Seitaro Terakura, Naoki Wada, Eiichi Morii, Junichi Nishimura, Kiyoshi Takeda, Yusuke Oji, Haruo Sugiyama, Junichi Takagi, Atsushi Kumanogoh

NATURE MEDICINE　Vol. 23　No. 12　p. 1436-+　2017/12　Research paper (scientific journal)

A Zbtb7a proto-oncogene as a novel target for miR-125a

Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji

MOLECULAR CARCINOGENESIS　Vol. 55　No. 12　p. 2001-2009　2016/12　Research paper (scientific journal)

Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.

Satoshi Takashima, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Yoshiki Nakae, Jun Nakata, Sumiyuki Nishida, Naoki Hosen, Naoya Tatsumi, Kenji Mizuguchi, Naoya Hashimoto, Yusuke Oji, Akihiro Tsuboi, Atsushi Kumanogoh, Haruo Sugiyama

Future science OA　Vol. 2　No. 4　2016/12　Research paper (scientific journal)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide

Yusuke Oji, Naoya Hashimoto, Akihiro Tsuboi, Yui Murakami, Miki Iwai, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Olga Elisseeva, Ryo Ichinohasama, Junichi Sakamoto, Satoshi Morita, Hiroko Nakajima, Satoshi Takashima, Yoshiki Nakae, Jun Nakata, Manabu Kawakami, Sumiyuki Nishida, Naoki Hosen, Fumihiro Fujiki, Soyoko Morimoto, Mayuko Adachi, Masahiro Iwamoto, Yoshihiro Oka, Toshiki Yoshimine, Haruo Sugiyama

INTERNATIONAL JOURNAL OF CANCER　Vol. 139　No. 6　p. 1391-1401　2016/09　Research paper (scientific journal)

Randomized phase II study of WT1 peptide vaccine plus gemcitabine for advanced pancreatic ductal adenocarcinoma (PDAC): Clinical efficacy and immune response

Nishida Sumiyuki, Ishikawa Takeshi, Kokura Satoshi, Egawa Shinichi, Koido Shigeo, Yasuda Hiroaki, Yanagimoto Hiroaki, Ishii Jun, Kanno Yoshihide, Oba Mari Saito, Sato Maho, Morimoto Soyoko, Eguchi Hidetoshi, Nagano Hiroaki, Homma Sadamu, Oka Yoshihiro, Morita Satoshi, Sugiyama Haruo

JOURNAL OF CLINICAL ONCOLOGY　Vol. 34　No. 15　2016/05/20

An Essential Role of the Avidity of T-Cell Receptor in Differentiation of Self-Antigen-reactive CD8(+) T Cells

Kenta Kondo, Fumihiro Fujiki, Hiroko Nakajima, Erika Yatsukawa, Soyoko Morimoto, Naoya Tatsumi, Sumiyuki Nishida, Jun Nakata, Yoshihiro Oka, Akihiro Tsuboi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 39　No. 3　p. 127-139　2016/04　Research paper (scientific journal)

Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Katsuhiko Nakano, Hiroko Kinoshita, Atsushi Okumura, Yuka Fujioka, Rika Urakawa, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eiji Miyoshi, Takako Hirata, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

WT1 peptide vaccine for the treatment of malignancies: Its development, recent progress, and future perspectives

Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Fumihiro Fujiki, Sumiyuki Nishida, Soyoko Morimoto, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Naoya Tatsumi, Naoki Hosen, Yusuke Oji, Haruo Sugiyama

Immunotherapy of Cancer: An Innovative Treatment Comes of Age　p. 159-185　2016/02/22　Part of collection (book)

An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen

PLOS ONE　Vol. 10　No. 12　2015/12　Research paper (scientific journal)

初発膠芽腫に対するテモゾロミド併用のWT1ペプチドワクチン療法

橋本 直哉, 坪井 昭博, 千葉 泰良, 香川 尚己, 有田 英之, 森本 創世子, 岡 芳弘, 尾路 祐介, 吉峰 俊樹, 杉山 治夫

日本癌学会総会記事　Vol. 74回　p. E-1223　2015/10

Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients

Yoshiki Nakae, Yoshihiro Oka, Fumihiro Fujiki, Soyoko Morimoto, Toshio Kamiya, Satoshi Takashima, Jun Nakata, Sumiyuki Nishida, Hiroko Nakajima, Naoki Hosen, Akihiro Tsuboi, Taiichi Kyo, Yusuke Oji, Kenji Mizuguchi, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 7　p. 791-804　2015/07　Research paper (scientific journal)

Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response

Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 64　No. 6　p. 707-716　2015/06　Research paper (scientific journal)

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms

Naoya Tatsumi, Nozomi Hojo, Hiroyuki Sakamoto, Rena Inaba, Nahoko Moriguchi, Keiko Matsuno, Mari Fukuda, Akihide Matsumura, Seiji Hayashi, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Haruo Sugiyama, Yusuke Oji

PLOS ONE　Vol. 10　No. 6　2015/06　Research paper (scientific journal)

Transduction of a Novel HLA-DRB1*04:05-restricted, WT1-specific TCR Gene into Human CD4(+) T Cells Confers Killing Activity Against Human Leukemia Cells

Akiko Katsuhara, Fumihiro Fujiki, Nao Aoyama, Satoe Tanii, Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Hiroko Nakajima, Kenta Kondo, Naoya Tatsumi, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Sumiyuki Nishida, Naoki Hosen, Shinji Sogo, Yusuke Oji, Haruo Sugiyama

ANTICANCER RESEARCH　Vol. 35　No. 3　p. 1251-1261　2015/03　Research paper (scientific journal)

Wilms' tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer

Koido Shigeo, Nishida Sumiyuki, Homma Sadamu, Takeda Yutaka, Komita Hideo, Morita Satoshi, Ito Toshinori, Morimoto Soyoko, Oka Yoshihiro, Yanagisawa Satoru, Toyama Yoichi, Ikegami Masahiro, Nagano Hiroaki, Ohkusa Toshifumi, Tajiri Hisao, Sugiyama Haruo

CANCER RESEARCH　Vol. 74　No. 19　2014/10/01

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity

J. Nakata, K. Nakano, A. Okumura, Y. Mizutani, H. Kinoshita, M. Iwai, K. Hasegawa, S. Morimoto, F. Fujiki, N. Tatsumi, H. Nakajima, Y. Nakae, S. Nishida, A. Tsuboi, Y. Oji, Y. Oka, H. Sugiyama, A. Kumanogoh, N. Hosen

LEUKEMIA　Vol. 28　No. 6　p. 1316-1325　2014/06　Research paper (scientific journal)

Wilms Tumor Gene ( WT1) Peptide- based Cancer Vaccine Combined With Gemcitabine for Patients With Advanced Pancreatic Cancer

Sumiyuki Nishida, Shigeo Koido, Yutaka Takeda, Sadamu Homma, Hideo Komita, Akitaka Takahara, Satoshi Morita, Toshinori Ito, Soyoko Morimoto, Kazuma Hara, Akihiro Tsuboi, Yoshihiro Oka, Satoru Yanagisawa, Yoichi Toyama, Masahiro Ikegami, Toru Kitagawa, Hidetoshi Eguchi, Hiroshi Wada, Hiroaki Nagano, Jun Nakata, Yoshiki Nakae, Naoki Hosen, Yusuke Oji, Toshio Tanaka, Ichiro Kawase, Atsushi Kumanogoh, Junichi Sakamoto, Yuichiro Doki, Masaki Mori, Toshifumi Ohkusa, Hisao Tajiri, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 37　No. 2　p. 105-114　2014/02　Research paper (scientific journal)

Maintenance of complete remission after allogeneic stem cell transplantation in leukemia patients treated with Wilms tumor 1 peptide vaccine

Maeda T, Hosen N, Fukushima K, Tsuboi A, Morimoto S, Matsui T, Sata H, Fujita J, Hasegawa K, Nishida S, Nakata J, Nakae Y, Takashima S, Nakajima H, Fujiki F, Tatsumi N, Kondo T, Hino M, Oji Y, Oka Y, Kanakura Y, Kumanogoh A, Sugiyama H

BLOOD CANCER JOURNAL　Vol. 3　No. 8　2013/08　Research paper (scientific journal)

HLA-DPB1*05

Yuhung Lin, Fumihiro Fujiki, Akiko Katsuhara, Yoshihiro Oka, Akihiro Tsuboi, Nao Aoyama, Satoe Tanii, Hiroko Nakajima, Naoya Tatsumi, Soyoko Morimoto, Taichi Tamanaka, Sho Tachino, Naoki Hosen, Sumiyuki Nishida, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

Journal of Immunotherapy　2013/04　Research paper (scientific journal)

Functional human Th17 clones with WT1-specific helper activity

Sho Tachino, Fumihiro Fujiki, Yoshihiro Oka, Akihiro Tsuboi, Soyoko Morimoto, Yu-Hung Lin, Taichi Tamanaka, Kenta Kondo, Hiroko Nakajima, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER IMMUNOLOGY IMMUNOTHERAPY　Vol. 62　No. 4　p. 801-810　2013/04　Research paper (scientific journal)

HLA-DPB1*05:01-restricted WT1 (332)-specific TCR-transduced CD4(+) T Lymphocytes Display a Helper Activity for WT1-specific CTL Induction and a Cytotoxicity Against Leukemia Cells

Yuhung Lin, Fumihiro Fujiki, Akiko Katsuhara, Yoshihiro Oka, Akihiro Tsuboi, Nao Aoyama, Satoe Tanii, Hiroko Nakajima, Naoya Tatsumi, Soyoko Morimoto, Taichi Tamanaka, Sho Tachino, Naoki Hosen, Sumiyuki Nishida, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

JOURNAL OF IMMUNOTHERAPY　Vol. 36　No. 3　p. 159-170　2013/04　Research paper (scientific journal)

Biased usage of T cell receptor β‐chain variable region genes of Wilms’ tumor gene (WT1)‐specific CD8⁺ T cells in patients with solid tumors and healthy donors

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

Cancer Science　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

Biased usage of T cell receptor ss-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+T cells in patients with solid tumors and healthy donors

Soyoko Morimoto, Yoshihiro Oka, Akihiro Tsuboi, Yukie Tanaka, Fumihiro Fujiki, Hiroko Nakajima, Naoki Hosen, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoki Kagawa, Naoya Hashimoto, Toshiki Yoshimine, Yusuke Oji, Atsushi Kumanogoh, Haruo Sugiyama

CANCER SCIENCE　Vol. 103　No. 3　p. 408-414　2012/03　Research paper (scientific journal)

Enhanced tumor immunity of WT1 peptide vaccination by interferon-beta administration

Hiroko Nakajima, Yoshihiro Oka, Akihiro Tsuboi, Naoya Tatsumi, Yumiko Yamamoto, Fumihiro Fujiki, Zheyu Li, Ayako Murao, Soyoko Morimoto, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Ichiro Kawase, Yoshitaka Isaka, Yusuke Oji, Haruo Sugiyama

VACCINE　Vol. 30　No. 4　p. 722-729　2012/01　Research paper (scientific journal)

Identification of a WT1 protein-derived peptide, WT1(187), as a HLA-A*0206-restricted, WT1-specific CTL epitope

Zheyu Li, Yoshihiro Oka, Akihiro Tsuboi, Fumihiro Fujiki, Yukie Harada, Hiroko Nakajima, Tomoki Masuda, Yoko Fukuda, Mai Kawakatsu, Soyoko Morimoto, Takamasa Katagiri, Naoya Tatsumi, Naoki Hosen, Toshiaki Shirakata, Sumiyuki Nishida, Yutaka Kawakami, Keiko Udaka, Ichiro Kawase, Yusuke Oji, Haruo Sugiyama

MICROBIOLOGY AND IMMUNOLOGY　Vol. 52　No. 11　p. 551-558　2008/11　Research paper (scientific journal)