顔写真

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Mizohata Eiichi
溝端 栄一
Mizohata Eiichi
溝端 栄一
Graduate School of Engineering Division of Applied Chemistry, Associate Professor (Lecturer)

keyword Enzyme chemistry,Biophysical Chemistry,Serial femtosecond crystallography (SFX),X-ray free electron laser (XFEL)

Research History 8

  1. 2015/04 - Present
    Osaka University Graduate School of Engineering Division of Applied Chemistry

  2. 2017/10 - 2021/03
    Japan Science and Technology Agency (JST) Strategic Basic Research Programs PRESTO Researcher (concurrent post)

  3. 2018/08 - 2020/07
    Ministry of Education, Culture, Sports, Science and Technology (MEXT) Program Officer (In charge of scientific research grants) (concurrent post)

  4. 2009/04 - 2015/03
    Osaka University Graduate School of Engineering Division of Applied Chemistry

  5. 2007/07 - 2009/03
    Diamond Light Source, UK Collaborative Researcher

  6. 2006/09 - 2009/03
    ERATO Iwata Human Receptor Crystallography Project (UK Lab) Researcher

  7. 2006/01 - 2009/03
    Imperial College London Department of Life Sciences Research Associate

  8. 2003/04 - 2005/12
    RIKEN Yokohama Institute Genomic Sciences Center Research Associate

Education 1

  1. Osaka University Graduate School of Engineering Department of Materials Chemistry

    2000/04 - 2003/03

Committee Memberships 2

  1. 日本結晶学会 編集委員 Academic society

    2018 - Present

  2. 日本生物物理学会 ウェブサイト編集委員 Academic society

    2019 - 2022/03

Professional Memberships 6

  1. 日本光合成学会

  2. 量子生命科学会

  3. 日本生物物理学会

  4. 日本化学会

  5. 日本蛋白質科学会

  6. 日本結晶学会

Research Areas 1

  1. Life sciences / Biophysics /

Awards 5

  1. 大阪ニュークリアサイエンス協会賞(ONSA賞)

    一般社団法人大阪ニュークリアサイエンス協会 2025/06

  2. The 18th Conference of the Asian Crystallographic Association (AsCA’2024), Poster Award

    Asian Crystallographic Association 2024/12

  3. Osaka University Prize

    2018/11

  4. 若手教員専門力アッププロジェクト優秀賞

    大阪大学 2015/04

  5. The 12th Conference of the Asian Crystallographic Association (AsCA’2013), Poster Award

    Asian Crystallographic Association 2013/12

Papers 119

  1. Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana

    Tsubasa Shoji, Yoshikazu Tanaka, Yu Nakashima, Eiichi Mizohata, Maki Komaki, Satoko Sugawara, Junichiro Takaya, Keiko Yonekura-Sakakibara, Hiroyuki Morita, Kazuki Saito, Tadayoshi Hirai

    Journal of Agricultural and Food Chemistry 2025/01/09 Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)
  2. Rational design of an artificial ethylbenzene hydroxylase using a molecular dynamics simulation to enhance enantioselectivity

    Koji Oohora, Yoshiyuki Kagawa, Takako Nishiura, Eiichi Mizohata, Ulrich Schwaneberg, Takashi Hayashi

    Chemistry Letters Vol. 53 No. 2 2023/12/19 Research paper (scientific journal)

    Publisher: Oxford University Press (OUP)
  3. Functional diversity and plasticity in the sugar preferences of Saccharomyces MALT transporters in domesticated yeasts

    Haruyo Hatanaka, Hiromi Toyonaga, Yukiko Ishida, Eiichi Mizohata, Eiichiro Ono

    FEMS Yeast Research Vol. foac055 2022/11 Research paper (scientific journal)

  4. Substrate Specificity of an Aminopropyltransferase and the Biosynthesis Pathway of Polyamines in the Hyperthermophilic Crenarchaeon Pyrobaculum calidifontis

    Wakao Fukuda, Mamoru Osaki, Yusuke Yasuda, Ryota Hidese, Tsunehiko Higuchi, Naoki Umezawa, Shinsuke Fujiwara, Eiichi Mizohata

    Catalysts Vol. 12 No. 5 2022/05 Research paper (scientific journal)

  5. Heavy Atom Detergent/Lipid Combined X-ray Crystallography for Elucidating Structure-function Relationships of Membrane Proteins

    Shinya Hanashima, Takanori Nakane, Eiichi Mizohata

    Membranes Vol. 11 No. 11 2021 Research paper (scientific journal)

  6. Improvement of Production and Isolation of Human Neuraminidase-1in CelluloCrystals

    Kotaro Koiwai, Jun Tsukimoto, Tetsuya Higashi, Fumitaka Mafuné, Ken Miyajima, Takanori Nakane, Naohiro Matsugaki, Ryuichi Kato, Serena Sirigu, Arjen Jakobi, Matthias Wilmanns, Michihiro Sugahara, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, Osamu Nureki, Eiichi Mizohata, Toru Nakatsu, Eriko Nango, So Iwata, Leonard M. G. Chavas, Toshiya Senda, Kohji Itoh, Fumiaki Yumoto

    ACS Applied Bio Materials Vol. 2 No. 11 p. 4941-4952 2019/11/18 Research paper (scientific journal)

  7. Improvement of production and isolation of human neuraminidase-1 in cellulo crystals

    Kotaro Koiwai, Jun Tsukimoto, Tetsuya Higashi, Fumitaka Mafune, Ken Miyajima, Takanori Nakane, Naohiro Matsugaki, Ryuichi Kato, Serena Sirigu, Arjen J Jakobi, Matthias Wilmanns, Michihiro Sugahara, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, Osamu Nureki, Eiichi Mizohata, Toru Nakatsu, Eriko Nango, So Iwata, Leonard Chavas, Toshiya Senda, Kohji Itoh, Fumiaki Yumoto

    ACS Appl. Bio Mater. 2019/10 Research paper (scientific journal)

  8. The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.

    Ryota Hidese, Masataka Toyoda, Ken-Ichi Yoshino, Wakao Fukuda, Gita Adhirani Wihardja, Seigo Kimura, Junso Fujita, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Eiichi Mizohata, Shinsuke Fujiwara

    The FEBS journal Vol. 286 No. 19 p. 3926-3940 2019/07 Research paper (scientific journal)

  9. The high resolution molecular movie taken by X-ray free electron laser

    Eiichi Mizohata

    2019/04 Research paper (other academic)

  10. Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface.

    Takefumi Yamashita, Eiichi Mizohata, Satoru Nagatoishi, Takahiro Watanabe, Makoto Nakakido, Hiroko Iwanari, Yasuhiro Mochizuki, Taisuke Nakayama, Yuji Kado, Yuki Yokota, Hiroyoshi Matsumura, Takeshi Kawamura, Tatsuhiko Kodama, Takao Hamakubo, Tsuyoshi Inoue, Hideaki Fujitani, Kouhei Tsumoto

    Structure (London, England : 1993) Vol. 27 No. 3 p. 519-527 2019/03 Research paper (scientific journal)

  11. Learning RuBisCO's birth and subsequent environmental adaptation.

    Hiroki Ashida, Eiichi Mizohata, Akiho Yokota

    Biochemical Society transactions Vol. 47 No. 1 p. 179-185 2019/02/28 Research paper (scientific journal)

  12. Cupid and Psyche system for the diagnosis and treatment of advanced cancer.

    Akira Sugiyama, Takeshi Kawamura, Toshiya Tanaka, Hirofumi Doi, Takefumi Yamashita, Keiko Shinoda, Hideaki Fujitani, Kenzo Yamatsugu, Yohei Shimizu, Toshifumi Tatsumi, Kazuki Takahashi, Motomu Kanai, Eiichi Mizohata, Tatsuya Kawato, Takefumi Doi, Tsuyoshi Inoue, Tatsuhiko Kodama

    Proceedings of the Japan Academy. Series B, Physical and biological sciences Vol. 95 No. 10 p. 602-611 2019 Research paper (scientific journal)

  13. SACLAの先端XFEL技術を用いたタンパク質構造研究

    溝端栄一

    2018/09 Research paper (other academic)

  14. Docking analysis of models for 4-hydroxy-3-methylbut-2-enyl diphosphate reductase and a ferredoxin from Botryococcus braunii, race B

    Uchida Hidenobu, Mizohata Eiichi, Okada Shigeru

    Plant Biotechnology Vol. 35 No. 3 p. 297-301 2018/08 Research paper (scientific journal)

    Publisher: Japanese Society for Plant Cell and Molecular Biology
  15. Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome.

    Nicole C Woitowich, Andrei S Halavaty, Patricia Waltz, Christopher Kupitz, Joseph Valera, Gregory Tracy, Kevin D Gallagher, Elin Claesson, Takanori Nakane, Suraj Pandey, Garrett Nelson, Rie Tanaka, Eriko Nango, Eiichi Mizohata, Shigeki Owada, Kensure Tono, Yasumasa Joti, Angela C Nugent, Hardik Patel, Ayesha Mapara, James Hopkins, Phu Duong, Dorina Bizhga, Svetlana E Kovaleva, Rachael St Peter, Cynthia N Hernandez, Wesley B Ozarowski, Shatabdi Roy-Chowdhuri, Jay-How Yang, Petra Edlund, Heikki Takala, Janne Ihalainen, Jennifer Brayshaw, Tyler Norwood, Ishwor Poudyal, Petra Fromme, John C H Spence, Keith Moffat, Sebastian Westenhoff, Marius Schmidt, Emina A Stojković

    IUCrJ Vol. 5 No. 5 p. 619-634 2018/08 Research paper (scientific journal)

  16. Crystallographic study on dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans

    Yohta Fukuda, Takuro Matsusaki, Ka Man Tse, Eiichi Mizohata, Michael E, P. Murphy, Tsuyoshi Inoue

    Acta Crystallogr D Struct Biol Vol. 74 No. 8 p. 769-777 2018/07 Research paper (scientific journal)

  17. Isolation and characterization of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene from Botryococcus braunii, race B

    Hidenobu Uchida, Koremitsu Sumimoto, Tomoka Oki, Ichiro Nishii, Eiichi Mizohata, Shigeki Matsunaga, Shigeru Okada

    Journal of Plant Research Vol. 131 No. 5 p. 1-10 2018/05/03 Research paper (scientific journal)

    Publisher: Springer Tokyo
  18. Serial femtosecond crystallography at the SACLA: breakthrough to dynamic structural biology

    Eiichi Mizohata, Takanori Nakane, Yohta Fukuda, Eriko Nango, So Iwata

    Biophysical Reviews Vol. 10 No. 2 p. 209-218 2018/04/01 Research paper (scientific journal)

    Publisher: Springer Verlag
  19. Loop of Streptomyces Feruloyl Esterase Plays an Important Role in the Enzyme's Catalyzing the Release of Ferulic Acid from Biomass.

    Misugi Uraji, Haruka Tamura, Eiichi Mizohata, Jiro Arima, Kun Wan, Ken'ichi Ogawa, Tsuyoshi Inoue, Tadashi Hatanaka

    Applied and environmental microbiology Vol. 84 No. 3 p. e02300-17 2017/11 Research paper (scientific journal)

  20. Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate

    Takehiko Tosha, Takashi Nomura, Takuma Nishida, Naoya Saeki, Kouta Okubayashi, Raika Yamagiwa, Michihiro Sugahara, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Go Ueno, Tetsunari Kimura, Tamao Hisano, Kazumasa Muramoto, Hitomi Sawai, Hanae Takeda, Eiichi Mizohata, Ayumi Yamashita, Yusuke Kanematsu, Yu Takano, Eriko Nango, Rie Tanaka, Osamu Nureki, Osami Shoji, Yuka Ikemoto, Hironori Murakami, Shigeki Owada, Kensuke Tono, Makina Yabashi, Masaki Yamamoto, Hideo Ago, So Iwata, Hiroshi Sugimoto, Yoshitsugu Shiro, Minoru Kubo

    NATURE COMMUNICATIONS Vol. 8 No. 1 2017/11 Research paper (scientific journal)

  21. Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain

    Daichi Murata, Hiroyuki Okano, Clement Angkawidjaja, Masato Akutsu, Shun-ichi Tanaka, Kenyu Kitahara, Takuya Yoshizawa, Hiroyoshi Matsumura, Yuji Kado, Eiichi Mizohata, Tsuyoshi Inoue, Satoshi Sano, Yuichi Koga, Shigenori Kanaya, Kazufumi Takano

    BIOCHEMISTRY Vol. 56 No. 47 p. 6281-6291 2017/11 Research paper (scientific journal)

  22. Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine

    Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara

    FEBS Journal Vol. 284 No. 21 p. 3684-3701 2017/11/01 Research paper (scientific journal)

    Publisher: Blackwell Publishing Ltd
  23. Damage-free protein structure determination using X-ray free electron laser at SACLA

    Eiichi Mizohata

    2017/10 Research paper (other academic)

  24. X線自由電子レーザーによる膜タンパク質構造決定法

    溝端栄一

    バイオサイエンスとインダストリー Vol. 75 No. 5 p. 415-417 2017/09

  25. Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography

    Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato, Atsushi Kodan, Tomohiro Yamaguchi, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Hiroshi Manya, Tamao Endo, Ryuichi Kato, Toshiya Senda, Hiroaki Kato, So Iwata, Hideo Ago, Masaki Yamamoto, Fumiaki Yumoto, Toru Nakatsu

    IUCRJ Vol. 4 No. 5 p. 639-647 2017/09 Research paper (scientific journal)

  26. Redox-dependent structural change in nitrite reductase visualized by SPring-8 and SACLA

    Eiichi Mizohata

    2017/09 Research paper (other academic)

  27. Trends in Methods for Accelerating Structure Determination of Membrane Proteins

    MIZOHATA Eiichi

    Nihon Kessho Gakkaishi Vol. 59 No. 4 p. 147-148 2017/08

    Publisher: The Crystallographic Society of Japan
  28. Structural basis for intramolecular interaction of post-translationally modified H-Ras.GTP prepared by protein ligation

    Haoliang Ke, Shigeyuki Matsumoto, Yosuke Murashima, Haruka Taniguchi-Tamura, Ryo Miyamoto, Yoko Yoshikawa, Chiemi Tsuda, Takashi Kumasaka, Eiichi Mizohata, Hironori Edamatsu, Tohru Kataoka

    FEBS LETTERS Vol. 591 No. 16 p. 2470-2481 2017/08 Research paper (scientific journal)

  29. Structural insights into a secretory abundant heat-soluble protein from an anhydrobiotic tardigrade, Ramazzottius varieornatus

    Yohta Fukuda, Yoshimasa Miura, Eiichi Mizohata, Tsuyoshi Inoue

    FEBS LETTERS Vol. 591 No. 16 p. 2458-2469 2017/08 Research paper (scientific journal)

  30. Redox-coupled proton transfer mechanism in nitrite reductase revealed by SPring-8 and SACLA

    Eiichi Mizohata, Yohta Fukuda, Tsuyoshi Inoue

    SPring-8/SACLA Research Frontiers 2016 2017/08 Research paper (bulletin of university, research institution)

  31. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ

    Junso Fujita, Yoko Maeda, Eiichi Mizohata, Tsuyoshi Inoue, Malvika Kaul, Ajit K. Parhi, Edmond J. LaVoie, Daniel S. Pilch, Hiroyoshi Matsumura

    ACS CHEMICAL BIOLOGY Vol. 12 No. 7 p. 1947-1955 2017/07 Research paper (scientific journal)

  32. Identification of the key interactions in structural transition pathway of FtsZ from Staphylococcus aureus

    Junso Fujita, Ryuhei Harada, Yoko Maeda, Yuki Saito, Eiichi Mizohata, Tsuyoshi Inoue, Yasuteru Shigeta, Hiroyoshi Matsumura

    JOURNAL OF STRUCTURAL BIOLOGY Vol. 198 No. 2 p. 65-73 2017/05 Research paper (scientific journal)

  33. Hydroxyethyl cellulose matrix applied to serial crystallography

    Michihiro Sugahara, Takanori Nakane, Tetsuya Masuda, Mamoru Suzuki, Shigeyuki Inoue, Changyong Song, Rie Tanaka, Toru Nakatsu, Eiichi Mizohata, Fumiaki Yumoto, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Keiji Numata, Eriko Nango, So Iwata

    SCIENTIFIC REPORTS Vol. 7 No. 1 2017/04 Research paper (scientific journal)

  34. New molecular packing in a crystal of pseudoazurin from Alcaligenes faecalis: a double-helical arrangement of blue copper

    Yohta Fukuda, Eiichi Mizohata, Tsuyoshi Inoue

    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS Vol. 73 p. 159-166 2017/03 Research paper (scientific journal)

  35. Serial femtosecond crystallography revises reaction mechanism of copper-containing nitrite reductase

    Yohta FUKUDA, Tsuyoshi INOUE, Eiichi MIZOHATA

    Vol. 30 No. 2 p. 53-60 2017/03

    Publisher:
  36. Damage-free protein structure determination by X-ray free electron laser

    Takanori Nakane, So Iwata, Eiichi Mizohata

    Seikagaku Vol. 89 No. 4 p. 571-576 2017 Research paper (scientific journal)

    Publisher: Japanese Biochemical Society
  37. Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography

    Keitaro Yamashita, Naoyuki Kuwabara, Takanori Nakane, Tomohiro Murai, Eiichi Mizohata, Michihiro Sugahara, Dongqing Pan, Tetsuya Masuda, Mamoru Suzuki, Tomomi Sato, Atsushi Kodan, Tomohiro Yamaguchi, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Hiroshi Manya, Tamao Endo, Ryuichi Kato, Toshiya Senda, Hiroaki Kato, So Iwata, Hideo Ago, Masaki Yamamoto, Fumiaki Yumoto, Toru Nakatsu

    IUCrJ Vol. 4 No. 5 p. 639-647 2017 Research paper (scientific journal)

    Publisher: International Union of Crystallography
  38. A RuBisCO-mediated carbon metabolic pathway in methanogenic archaea

    Takunari Kono, Sandhya Mehrotra, Chikako Endo, Natsuko Kizu, Mami Matusda, Hiroyuki Kimura, Eiichi Mizohata, Tsuyoshi Inoue, Tomohisa Hasunuma, Akiho Yokota, Hiroyoshi Matsumura, Hiroki Ashida

    NATURE COMMUNICATIONS Vol. 8 No. 14007 2017/01 Research paper (scientific journal)

  39. Proteins in Serial Femtosecond Crystallography

    Eiichi Mizohata

    2016/12 Research paper (international conference proceedings)

  40. A three-dimensional movie of structural changes in bacteriorhodopsin

    Eriko Nango, Antoine Royant, Minoru Kubo, Takanori Nakane, Cecilia Wickstrand, Tetsunari Kimura, Tomoyuki Tanaka, Kensuke Tono, Changyong Song, Rie Tanaka, Toshi Arima, Ayumi Yamashita, Jun Kobayashi, Toshiaki Hosaka, Eiichi Mizohata, Przemyslaw Nogly, Michihiro Sugahara, Daewoong Nam, Takashi Nomura, Tatsuro Shimamura, Dohyun Im, Takaaki Fujiwara, Yasuaki Yamanaka, Byeonghyun Jeon, Tomohiro Nishizawa, Kazumasa Oda, Masahiro Fukuda, Rebecka Andersson, Petra Bath, Robert Dods, Jan Davidsson, Shigeru Matsuoka, Satoshi Kawatake, Michio Murata, Osamu Nureki, Shigeki Owada, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Gebhard Schertler, Makina Yabashi, Ana-Nicoleta Bondar, Jorg Standfuss, Richard Neutze, So Iwata

    SCIENCE Vol. 354 No. 6319 p. 1552-1557 2016/12 Research paper (scientific journal)

  41. Proteins in Serial Femtosecond Crystallography

    Eiichi Mizohata

    2016/12 Research paper (international conference proceedings)

  42. Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent

    Takanori Nakane, Shinya Hanashima, Mamoru Suzuki, Haruka Saiki, Taichi Hayashi, Keisuke Kakinouchi, Shigeru Sugiyama, Satoshi Kawatake, Shigeru Matsuoka, Nobuaki Matsumori, Eriko Nango, Jun Kobayashi, Tatsuro Shimamura, Kanako Kimura, Chihiro Mori, Naoki Kunishima, Michihiro Sugahara, Yoko Takakyu, Shigeyuki Inoue, Tetsuya Masuda, Toshiaki Hosaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Tsuyoshi Inoue, Osamu Nureki, So Iwata, Michio Murata, Eiichi Mizohata

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 113 No. 46 p. 13039-13044 2016/11 Research paper (scientific journal)

  43. Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity

    Kenji Ishimoto, Natsuko Kawamata, Yoshie Uchihara, Moeka Okubo, Reiko Fujimoto, Eiko Gotoh, Keisuke Kakinouchi, Eiichi Mizohata, Nobumasa Hino, Yoshiaki Okada, Yasuhiro Mochizuki, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Tsuyoshi Inoue, Keisuke Tachibana, Takefumi Doi

    PLOS ONE Vol. 11 No. 10 2016/10 Research paper (scientific journal)

  44. SACLAが解明した銅含有亜硝酸還元酵素の常温無損傷構造

    溝端栄一

    2016/06 Research paper (other academic)

  45. Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography

    Yohta Fukuda, Ka Man Tse, Mamoru Suzuki, Kay Diederichs, Kunio Hirata, Takanori Nakane, Michihiro Sugahara, Eriko Nango, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Changyong Song, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Hiroyoshi Matsumura, Tsuyoshi Inoue, So Iwata, Eiichi Mizohata

    JOURNAL OF BIOCHEMISTRY Vol. 159 No. 5 p. 527-538 2016/05 Research paper (scientific journal)

  46. Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography

    Yohta Fukuda, Ka Man Tsea, Takanori Nakane, Toru Nakatsu, Mamoru Suzuki, Michihiro Sugahara, Shigeyuki Inoue, Tetsuya Masuda, Fumiaki Yumoto, Naohiro Matsugaki, Eriko Nango, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Changyong Song, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Michael E. P. Murphy, Tsuyoshi Inoue, So Iwata, Eiichi Mizohata

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 113 No. 11 p. 2928-2933 2016/03 Research paper (scientific journal)

  47. Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP

    Jacques-Philippe Colletier, Michel Sliwa, Francois-Xavier Gallat, Michihiro Sugahara, Virginia Guillon, Giorgio Schiro, Nicolas Coquelle, Joyce Woodhouse, Laure Roux, Guillaume Gotthard, Antoine Royant, Lucas Martinez Uriarte, Cyril Ruckebusch, Yasumasa Joti, Martin Byrdin, Eiichi Mizohata, Eriko Nango, Tomoyuki Tanaka, Kensuke Tono, Makina Yabashi, Virgile Adam, Marco Cammarata, Ilme Schlichting, Dominique Bourgeois, Martin Weik

    JOURNAL OF PHYSICAL CHEMISTRY LETTERS Vol. 7 No. 5 p. 882-887 2016/03 Research paper (scientific journal)

  48. Crystal Structures and Coordination Behavior of Aqua- and Cyano-Co(III) Tetradehydrocorrins in the Heme Pocket of Myoglobin

    Yoshitsugu Morita, Koji Oohora, Eiichi Mizohata, Akiyoshi Sawada, Takashi Kamachi, Kazunari Yoshizawa, Tsuyoshi Inoue, Takashi Hayashi

    INORGANIC CHEMISTRY Vol. 55 No. 3 p. 1287-1295 2016/02 Research paper (scientific journal)

  49. 5D4I: Intact nitrite complex of a copper nitrite reductase determined by serial femtosecond crystallography

    Fukuda Y, Tse KM, Nakane T, Nakatsu T, Suzuki M, Sugahara M, Inoue S, Masuda T, Yumoto F, Matsugaki N, Nango E, Tono K, Joti Y, Kameshima T, Song C, Hatsui T, Yabashi M, Nureki O, Murphy MEP, Inoue T, Iwata S, Mizohata E

    Worldwide Protein Data Bank 2016

  50. 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA

    Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E

    Worldwide Protein Data Bank 2016

  51. 4YSD: Room temperature structure of copper nitrite reductase from Geobacillus thermodenitrificans

    Fukuda Y, Tse KM, Suzuki M, Diederichs K, Hirata K, Nakane T, Sugahara M, Nango E, Tono K, Joti Y, Kameshima T, Song C, Hatsui T, Yabashi M, Nureki O, Matsumura H, Inoue T, Iwata S, Mizohata E

    Worldwide Protein Data Bank 2016

  52. 4YSA: Completely oxidized structure of copper nitrite reductase from Geobacillus thermodenitrificans

    Fukuda Y, Tse KM, Suzuki M, Diederichs K, Hirata K, Nakane T, Sugahara M, Nango E, Tono K, Joti Y, Kameshima T, Song C, Hatsui T, Yabashi M, Nureki O, Matsumura H, Inoue T, Iwata S, Mizohata E

    Worldwide Protein Data Bank 2016

  53. Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5 STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES

    Yuji Kado, Eiichi Mizohata, Satoru Nagatoishi, Mariko Iijima, Keiko Shinoda, Takamitsu Miyafusa, Taisuke Nakayama, Takuma Yoshizumi, Akira Sugiyama, Takeshi Kawamura, Young-Hun Lee, Hiroyoshi Matsumura, Hirofumi Doi, Hideaki Fujitani, Tatsuhiko Kodama, Yoshikazu Shibasaki, Kouhei Tsumoto, Tsuyoshi Inoue

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 291 No. 5 p. 2319-2330 2016/01 Research paper (scientific journal)

  54. A Highly Active Biohybrid Catalyst for Olefin Metathesis in Water: Impact of a Hydrophobic Cavity in a beta-Barrel Protein

    Daniel F. Sauer, Tomoki Himiyama, Kengo Tachikawa, Kazuki Fukumoto, Akira Onoda, Eiichi Mizohata, Tsuyoshi Inoue, Marco Bocola, Ulrich Schwaneberg, Takashi Hayashi, Jun Okuda

    ACS CATALYSIS Vol. 5 No. 12 p. 7519-7522 2015/12 Research paper (scientific journal)

  55. Structure-based protein engineering for cancer therapy

    Eiichi Mizohata, Tatsuya Kawato, Taisuke Nakayama, Yuji Kado, Tsuyoshi Inoue, Yohei Shimizu, Motomu Kanai, Hirofumi Doi, Akira Sugiyama, Takao Hamakubo, Tasuhiko Kodama

    2015/12 Research paper (international conference proceedings)

  56. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

    Takanori Nakane, Changyong Song, Mamoru Suzuki, Eriko Nango, Jun Kobayashi, Tetsuya Masuda, Shigeyuki Inoue, Eiichi Mizohata, Toru Nakatsu, Tomoyuki Tanaka, Rie Tanaka, Tatsuro Shimamura, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Osamu Nureki, So Iwata, Michihiro Sugahara

    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY Vol. 71 p. 2519-2525 2015/12 Research paper (scientific journal)

  57. 米国 LCLS 視察および UCSF ワークショップ講演に参加して

    溝端栄一

    FASだより No. 11 p. 1-3 2015/11 Research paper (other academic)

  58. An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography

    Keitaro Yamashita, Dongqing Pan, Tomohiko Okuda, Michihiro Sugahara, Atsushi Kodan, Tomohiro Yamaguchi, Tomohiro Murai, Keiko Gomi, Naoki Kajiyama, Eiichi Mizohata, Mamoru Suzuki, Eriko Nango, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Jaehyun Park, Changyong Song, Takaki Hatsui, Makina Yabashi, So Iwata, Hiroaki Kato, Hideo Ago, Masaki Yamamoto, Toru Nakatsu

    SCIENTIFIC REPORTS Vol. 5 2015/09 Research paper (scientific journal)

  59. Insights into unknown foreign ligand in copper nitrite reductase

    Yohta Fukuda, Ka Man Tse, Yuji Kado, Eiichi Mizohata, Hiroyoshi Matsumura, Tsuyoshi Inoue

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 464 No. 2 p. 622-628 2015/08 Research paper (scientific journal)

  60. Damage-free structure determination by SFX at SACLA

    Eiichi Mizohata

    2015/06

  61. Crystal structure of streptavidin mutant with low immunogenicity.

    Tatsuya Kawato, Eiichi Mizohata, Tomohiro Meshizuka, Hirofumi Doi, Takeshi Kawamura, Hiroyoshi Matsumura, Kyohei Yumura, Kouhei Tsumoto, Tatsuhiko Kodama, Tsuyoshi Inoue, Akira Sugiyama

    Journal of bioscience and bioengineering Vol. 119 No. 6 p. 642-7 2015/06 Research paper (scientific journal)

  62. Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.

    Tatsuya Kawato, Eiichi Mizohata, Yohei Shimizu, Tomohiro Meshizuka, Tomohiro Yamamoto, Noriaki Takasu, Masahiro Matsuoka, Hiroyoshi Matsumura, Tatsuhiko Kodama, Motomu Kanai, Hirofumi Doi, Tsuyoshi Inoue, Akira Sugiyama

    Journal of biochemistry Vol. 157 No. 6 p. 467-75 2015/06 Research paper (scientific journal)

  63. Damage-free structure determination by SFX at SACLA

    Eiichi Mizohata

    2015/06

  64. Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser

    Kensuke Tono, Eriko Nango, Michihiro Sugahara, Changyong Song, Jaehyun Park, Tomoyuki Tanaka, Rie Tanaka, Yasumasa Joti, Takashi Kameshima, Shun Ono, Takaki Hatsui, Eiichi Mizohata, Mamoru Suzuki, Tatsuro Shimamura, Yoshiki Tanaka, So Iwata, Makina Yabashi

    JOURNAL OF SYNCHROTRON RADIATION Vol. 22 No. 3 p. 532-537 2015/05 Research paper (scientific journal)

  65. The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein

    Takashi Kawasaki, Takahiro Saka, Shouhei Mine, Eiichi Mizohata, Tsuyoshi Inoue, Hiroyoshi Matsumura, Takaaki Sato

    FEBS LETTERS Vol. 589 No. 10 p. 1136-1142 2015/04 Research paper (scientific journal)

  66. Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses

    Taisuke Nakayama, Eiichi Mizohata, Takefumi Yamashita, Satoru Nagatoishi, Makoto Nakakido, Hiroko Iwanari, Yasuhiro Mochizuki, Yuji Kado, Yuki Yokota, Reiko Satoh, Kouhei Tsumoto, Hideaki Fujitani, Tatsuhiko Kodama, Takao Hamakubo, Tsuyoshi Inoue

    PROTEIN SCIENCE Vol. 24 No. 3 p. 328-340 2015/03 Research paper (scientific journal)

  67. Water-mediated recognition of simple alkyl chains by heart-type fatty acid binding protein

    S. Matsuoka†, S. Sugiyama†, D. Matsuoka, M. Hirose, L. Sébastien, H. Ano, T. Hara, O. Ichihara, R. Kimura, S. Murakami, H. Ishida, E. Mizohata, T. Inoue, M. Murata, These two authors contributed equally to this wor

    Angew. Chem. Int. Ed. Vol. 54 No. 5 p. 1508-1511 2015/01 Research paper (scientific journal)

  68. Luciferin-regenerating enzyme solved by SIRAS using XFEL (refined against Hg derivative data)

    Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E, Suzuki M, Nango E, Tono K, Joti Y, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Iwata S, Kato H, Ago H, Yamamoto M, Nakatsu T

    Worldwide Protein Data Bank 2015

  69. Luciferin-regenerating enzyme solved by SAD using synchrotron radiation at room temperature

    Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E, Suzuki M, Nango E, Tono K, Joti Y, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Iwata S, Kato H, Ago H, Yamamoto M, Nakatsu T

    Worldwide Protein Data Bank 2015

  70. 4YOP: CRYSTAL STRUCTURE OF HEN EGG-WHITE LYSOZYME

    Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, Tanaka R, Shimamura T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Iwata S, Sugahara M

    Worldwide Protein Data Bank 2015

  71. シリアルフェムト秒X線結晶解析(SFX)が 明かすタンパク質構造

    溝端栄一

    2015/01 Research paper (other academic)

  72. Structure-based design and synthesis of a bivalent iminobiotin analog showing strong affinity toward a low immunogenic streptavidin mutant.

    Tatsuya Kawato, Eiichi Mizohata, Yohei Shimizu, Tomohiro Meshizuka, Tomohiro Yamamoto, Noriaki Takasu, Masahiro Matsuoka, Hiroyoshi Matsumura, Tatsuhiko Kodama, Motomu Kanai, Hirofumi Doi, Tsuyoshi Inoue, Akira Sugiyama

    Bioscience, biotechnology, and biochemistry Vol. 79 No. 4 p. 640-2 2015 Research paper (scientific journal)

  73. Water-Mediated Recognition of Simple Alkyl Chains by Heart-Type Fatty-Acid-Binding Protein

    Shigeru Matsuoka, Shigeru Sugiyama, Daisuke Matsuoka, Mika Hirose, Sebastien Lethu, Hikaru Ano, Toshiaki Hara, Osamu Ichihara, S. Roy Kimura, Satoshi Murakami, Hanako Ishida, Eiichi Mizohata, Tsuyoshi Inoue, Michio Murata

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 54 No. 5 p. 1508-1511 2015/01 Research paper (scientific journal)

  74. シリアルフェムト秒X線結晶解析(SFX)が 明かすタンパク質構造

    溝端栄一

    2015/01 Research paper (other academic)

  75. Grease matrix as a versatile carrier of proteins for serial crystallography

    Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masudala, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata

    NATURE METHODS Vol. 12 No. 1 p. 61-63 2015/01 Research paper (scientific journal)

  76. 銅含有亜硝酸還元酵素の真のすがたにせまる結晶構造解析

    福田庸太, 溝端栄一, 井上豪

    Diffraction structural biology Vol. 8 No. 3 2014/10

  77. Protein structure analyses using X-ray free-electron lasers

    Eiichi MIZOHATA, Eriko NANGO, Michihiro SUGAHARA, Mamoru SUZUKI, So IWATA

    日本結晶学会誌 Vol. 56 No. 4 p. 241-246 2014/08

  78. In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?

    Francois-Xavier Gallat, Naohiro Matsugaki, Nathan P. Coussens, Koichiro J. Yagi, Marion Boudes, Tetsuya Higashi, Daisuke Tsuji, Yutaka Tatano, Mamoru Suzuki, Eiichi Mizohata, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Jaehyun Park, Changyong Song, Takaki Hatsui, Makina Yabashi, Eriko Nango, Kohji Itoh, Fasseli Coulibaly, Stephen Tobe, S. Ramaswamy, Barbara Stay, So Iwata, Leonard M. G. Chavas

    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES Vol. 369 No. 1647 2014/07 Research paper (scientific journal)

  79. Crystal structure of FtsA from Staphylococcus aureus

    Junso Fujita, Yoko Maeda, Chioko Nagao, Yuko Tsuchiya, Yuma Miyazaki, Mika Hirose, Eiichi Mizohata, Yoshimi Matsumoto, Tsuyoshi Inoue, Kenji Mizuguchi, Hiroyoshi Matsumura

    FEBS LETTERS Vol. 588 No. 10 p. 1879-1885 2014/05 Research paper (scientific journal)

  80. Rhodium-Complex-Linked Hybrid Biocatalyst: Stereo-Controlled Phenylacetylene Polymerization within an Engineered Protein Cavity

    Kazuki Fukumoto, Akira Onoda, Eiichi Mizohata, Marco Bocola, Tsuyoshi Inoue, Ulrich Schwaneberg, Takashi Hayashi

    CHEMCATCHEM Vol. 6 No. 5 p. 1229-1235 2014/05 Research paper (scientific journal)

  81. Structural insights into the function of a thermostable copper-containing nitrite reductase

    Yohta Fukuda, Ka Man Tse, Masami Lintuluoto, Yoshifumi Fukunishi, Eiichi Mizohata, Hiroyoshi Matsumura, Hideto Takami, Masaki Nojiri, Tsuyoshi Inoue

    JOURNAL OF BIOCHEMISTRY Vol. 155 No. 2 p. 123-135 2014/02 Research paper (scientific journal)

  82. Thaumatin structure determined by SPring-8 Angstrom Compact free electron Laser (SACLA)

    Masuda T, Nango E, Sugahara M, Mizohata E, Tanaka T, Tanaka R, Suzuki M, Mikami B, Iwata S

    Worldwide Protein Data Bank 2014

  83. Serial femtosecond X-ray structure of human fatty acid-binding protein type-3 (FABP3) in complex with stearic acid (C18:0) determined using X-ray free-electron laser at SACLA

    Mizohata E, Suzuki M, Kakinouchi K, Sugiyama S, Murata M, Sugahara M, Nango E, Tanaka T, Tanaka R, Tono K, Song C, Hatsui T, Joti Y, Yabashi M, Iwata S

    Worldwide Protein Data Bank 2014

  84. XFEL microcrystallography at SACLA: the next generation of structural biology

    Eiichi Mizohata

    2014/01

  85. Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model

    Takashi Hayashi, Yoshitsugu Morita, Eiichi Mizohata, Koji Oohora, Jun Ohbayashi, Tsuyoshi Inoue, Yoshio Hisaeda

    CHEMICAL COMMUNICATIONS Vol. 50 No. 83 p. 12560-12563 2014 Research paper (scientific journal)

  86. XFEL microcrystallography at SACLA: the next generation of structural biology

    Eiichi Mizohata

    2014/01 Research paper (international conference proceedings)

  87. Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies

    Young-Hun Lee, Mariko Iijima, Yuji Kado, Eiichi Mizohata, Tsuyoshi Inoue, Akira Sugiyama, Hirofumi Doi, Yoshikazu Shibasaki, Tatsuhiko Kodama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 441 No. 4 p. 1011-1017 2013/11 Research paper (scientific journal)

  88. C(sp(3))-H Bond Hydroxylation Catalyzed by Myoglobin Reconstituted with Manganese Porphycene

    Koji Oohora, Yushi Kihira, Eiichi Mizohata, Tsuyoshi Inoue, Takashi Hayashi

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 135 No. 46 p. 17282-17285 2013/11 Research paper (scientific journal)

  89. Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid

    Mika Hirose, Shigeru Sugiyama, Hanako Ishida, Mayumi Niiyama, Daisuke Matsuoka, Toshiaki Hara, Eiichi Mizohata, Satoshi Murakami, Tsuyoshi Inoue, Shigeru Matsuoka, Michio Murata

    JOURNAL OF SYNCHROTRON RADIATION Vol. 20 p. 923-928 2013/11 Research paper (scientific journal)

  90. SACLAを利用したXFEL微結晶構造解析

    溝端栄一, 鈴木守, 南後恵理子, 森田能次, 垣之内啓介, 田中里枝, 登野健介, 城地保昌, 亀島敬, Jaehyun Park, Changyong Song, 初井宇記, 矢橋牧名, Thomas A White, 北郷悠, 大洞光司, 石田英子, 廣瀬未果, 杉山成, 村田道雄, 林高史, 高木淳一, 井上豪, 岩田想

    日本結晶学会年会講演要旨集 Vol. 2013 2013/10 Research paper (other academic)

  91. Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus

    Junso Fujita, Yuma Miyazaki, Mika Hirose, Chioko Nagao, Eiichi Mizohata, Yoshimi Matsumoto, Kenji Mizuguchi, Tsuyoshi Inoue, Hiroyoshi Matsumura

    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS Vol. 69 No. 8 p. 895-898 2013/08 Research paper (scientific journal)

  92. Fabrication of Poly(gamma-glutamic acid) Monolith by Thermally Induced Phase Separation and Its Application

    Sung-Bin Park, Takashi Fujimoto, Eiichi Mizohata, Tsuyoshi Inoue, Moon-Hee Sung, Hiroshi Uyama

    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY Vol. 23 No. 7 p. 942-952 2013/07 Research paper (scientific journal)

  93. Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth.

    Yoshihiro Kano, Masamitsu Konno, Katsuya Ohta, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshinori Kagawa, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Takahito Fukusumi, Yuko Noguchi, Miyuki Ozaki, Toshihiro Kudo, Daisuke Sakai, Taroh Satoh, Masaru Ishii, Eiichi Mizohata, Takeshi Inoue, Masaki Mori, Yuichiro Doki, Hideshi Ishii

    Molecular and clinical oncology Vol. 1 No. 4 p. 753-757 2013/07 Research paper (scientific journal)

  94. 3P034 Toward an understanding of lipid-protein interactions, the use of the heavy atom labeled fatty acid analogues(01A. Protein: Structure,Poster)

    Sugiyama Shigeru, Hirose Mika, Ishida Hanako, Lethu Sebastien, Ano Hikaru, Matsuoka Daisuke, Hara Toshiaki, Mizohata Eiichi, Inoue Tsuyoshi, Matsuoka Shigeru, Murata Michio

    Seibutsu Butsuri Vol. 53 No. 1 2013

    Publisher: The Biophysical Society of Japan General Incorporated Association
  95. Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.

    Tetsuro Yoshimaru, Masato Komatsu, Taisuke Matsuo, Yi-An Chen, Yoichi Murakami, Kenji Mizuguchi, Eiichi Mizohata, Tsuyoshi Inoue, Miki Akiyama, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Yasuo Miyoshi, Mitsunori Sasa, Yusuke Nakamura, Toyomasa Katagiri

    Nature communications Vol. 4 p. 2443-2443 2013 Research paper (scientific journal)

  96. Crystallization and preliminary X-ray crystallographic analysis of UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera

    Eiichi Mizohata, Takuma Okuda, Seika Hatanaka, Taisuke Nakayama, Manabu Horikawa, Toru Nakayama, Eiichiro Ono, Tsuyoshi Inoue

    Acta Crystallographica Section F: Structural Biology and Crystallization Communications Vol. 69 No. 1 p. 65-68 2013/01 Research paper (scientific journal)

  97. Crystal Structure of Rice Rubisco and Implications for Activation Induced by Positive Effectors NADPH and 6-Phosphogluconate

    Hiroyoshi Matsumura, Eiichi Mizohata, Hiroyuki Ishida, Ayako Kogami, Takeshi Ueno, Amane Makino, Tsuyoshi Inoue, Akiho Yokota, Tadahiko Mae, Yasushi Kai

    JOURNAL OF MOLECULAR BIOLOGY Vol. 422 No. 1 p. 75-86 2012/09 Research paper (scientific journal)

  98. The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase

    Yasuhide Takashima, Eiichi Mizohata, Sudaratana R. Krungkrai, Yoshifumi Fukunishi, Takayoshi Kinoshita, Tsuneaki Sakata, Hiroyoshi Matsumura, Jerapan Krungkrai, Toshihiro Horii, Tsuyoshi Inoue

    JOURNAL OF BIOCHEMISTRY Vol. 152 No. 2 p. 133-138 2012/08 Research paper (scientific journal)

  99. Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum

    Yasuhide Takashima, Eiichi Mizohata, Keiji Tokuoka, Sudaratana R. Krungkrai, Yukiko Kusakari, Saki Konishi, Atsuko Satoh, Hiroyoshi Matsumura, Jerapan Krungkrai, Toshihiro Horii, Tsuyoshi Inoue

    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS Vol. 68 No. 2 p. 244-246 2012/02 Research paper (scientific journal)

  100. Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F2a synthase, AKR1B3

    Yasuhide Takashima, Seika Hatanaka, Eiichi Mizohata, Nanae Nagata, Yoshifumi Fukunishi, Hiroyoshi Matsumura, Yoshihiro Urade, Tsuyoshi Inoue

    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS Vol. 67 No. 12 p. 1630-1632 2011/12 Research paper (scientific journal)

  101. Structural insight into the stereoselective production of PGF(2 alpha) by Old Yellow Enzyme from Trypanosoma cruzi

    Naoki Okamoto, Keishi Yamaguchi, Eiichi Mizohata, Keiji Tokuoka, Nahoko Uchiyama, Shigeru Sugiyama, Hiroyoshi Matsumura, Koji Inaka, Yoshihiro Urade, Tsuyoshi Inoue

    JOURNAL OF BIOCHEMISTRY Vol. 150 No. 5 p. 563-568 2011/11 Research paper (scientific journal)

  102. Application of membrane protein crystallography for antibody drug development

    MIZOHATA Eiichi, INOUE Tsuyoshi

    Bioscience & industry Vol. 68 No. 4 p. 241-245 2010/07

    Publisher:
  103. An evolutionally conserved Lys122 is essential for function in Rhodospirillum rubrum bona fide RuBisCO and Bacillus subtilis RuBisCO-like protein

    Toshihiro Nakano, Hiroki Ashida, Eiichi Mizohata, Hiroyoshi Matsumura, Akiho Yokota

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 392 No. 2 p. 212-216 2010/02 Research paper (scientific journal)

  104. Promotion of Crystal Nucleation of Protein by Semi-Solid Agarose Gel

    Kana Tanabe, Mika Hirose, Ryota Murai, Shigeru Sugiyama, Noriko Shimizu, Mihoko Maruyama, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Eiichi Mizohata, Tsuyoshi Inoue, Hiroyoshi Matsumura

    APPLIED PHYSICS EXPRESS Vol. 2 No. 12 2009/12 Research paper (scientific journal)

  105. Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP

    Noriko Handa, Eiichi Mizohata, Seiichiro Kishishita, Mitsutoshi Toyama, Satoshi Morita, Tomomi Uchikubo-Kamo, Ryogo Akasaka, Kenji Omori, Jun Kotera, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 28 p. 19657-19664 2008/07 Research paper (scientific journal)

  106. A high-throughput method for membrane protein solubility screening: The ultracentrifugation dispersity sedimentation assay

    Daniel A. P. Gutmann, Eiichi Mizohata, Simon Newstead, Sebastian Ferrandon, Peter J. F. Henderson, Hendrik W. Van Veen, Bernadette Byrne

    PROTEIN SCIENCE Vol. 16 No. 7 p. 1422-1428 2007/07 Research paper (scientific journal)

  107. Crystal structure of the single-domain rhodanese homologue TTHA0613 from Thermus thermophilus HB8

    M Hattori, E Mizohata, A Tatsuguchi, R Shibata, S Kishishita, K Murayama, T Terada, S Kuramitsu, M Shirouzu, S Yokoyama

    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS Vol. 64 No. 1 p. 284-287 2006/07 Research paper (scientific journal)

  108. Crystal structure of the hypothetical protein TTHA1013 from Thermus thermophilus HB8

    M Hattori, E Mizohata, M Manzoku, Y Bessho, K Murayama, T Terada, S Kuramitsu, M Shirouzu, S Yokoyama

    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS Vol. 61 No. 4 p. 1117-1120 2005/12 Research paper (scientific journal)

  109. Crystal structure of an archaeal peroxiredoxin from the aerobic hyperthermophilic crenarchaeon Aeropyrum pernix K1

    E Mizohata, H Sakai, E Fusatomi, T Terada, KK Murayama, M Shirouzu, S Yokoyama

    JOURNAL OF MOLECULAR BIOLOGY Vol. 354 No. 2 p. 317-329 2005/11 Research paper (scientific journal)

  110. 植物の改良を目指した葉緑体蛋白質の構造と機能の研究

    溝端栄一

    日本放射光学会誌(放射光) Vol. 16 No. 4 p. 62-63 2003/07

  111. What is the secret of the high functionality of Rubisco from an acido-thermophilic red alga Galdieria partita? The speculation by X-ray crystallography

    Mizohata E, Ueno T, Okano Y, Matsumura H, Kai Y

    2003/03 Research paper (other academic)

  112. Chemical modification of arginine alleviates the decline in activity during catalysis of spinach Rubisco

    E Mizohata, M Anwaruzzaman, H Okuno, KI Tomizawa, S Shigeoka, Y Kai, A Yokota

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 301 No. 2 p. 591-597 2003/02 Research paper (scientific journal)

  113. What is the secret of the high functionality of Rubisco from an acido-thermophilic red alga Galdieria partita? The speculation by x-ray crystallography

    E Mizohata, T Ueno, H Matsumura, Y Kai

    PLANT AND CELL PHYSIOLOGY Vol. 44 p. S1-S1 2003 Research paper (other academic)

  114. 植物の光合成の改良により持続可能な開発に貢献する事を目指した葉緑体蛋白質の構造と機能の研究

    溝端栄一

    21世紀COEプログラム「自然共生化学の創成」 平成14年度 若手研究者の自発的研究活動に対する支援 活動報告書 p. 63-66 2003/01 Research paper (bulletin of university, research institution)

  115. Crystal structure of activated ribulose-1,5-bisphosphate carboxylase/oxygenase from green alga Chlamydomonas reinhardtii complexed with 2-carboxyarabinito-1,5-bisphosphate

    E. Mizohata, H. Matsumura, Y. Okano, M. Kumei, H. Takuma, J. Onodera, K. Kato, N. Shibata, T. Inoue, A. Yokota, Y. Kai

    Annual report of Osaka University Academic Achievement 2001-2002 Vol. 3 2003/01 Research paper (bulletin of university, research institution)

  116. What is the secret of the high functionality of Rubisco from an acido-thermophilic red alga Galdieria partita? The speculation by x-ray crystallography

    E Mizohata, T Ueno, H Matsumura, Y Kai

    PLANT AND CELL PHYSIOLOGY Vol. 44 p. S1-S1 2003 Research paper (other academic)

  117. X-ray structure of Galdieria Rubisco complexed with one sulfate ion per active site

    Y Okano, E Mizohata, Y Xie, H Matsumura, H Sugawara, T Inoue, A Yokota, Y Kai

    FEBS LETTERS Vol. 527 No. 1-3 p. 33-36 2002/09 Research paper (scientific journal)

  118. Crystal structure of activated ribulose-1,5-bisphosphate carboxylase/oxygenase from green alga Chlamydomonas reinhardtii complexed with 2-carboxyarabinitol-1,5-bisphosphate

    E Mizohata, H Matsumura, Y Okano, M Kumei, H Takuma, J Onodera, K Kato, N Shibata, T Inoue, A Yokota, Y Kai

    JOURNAL OF MOLECULAR BIOLOGY Vol. 316 No. 3 p. 679-691 2002/02 Research paper (scientific journal)

  119. Crystallization and preliminary X-ray diffraction analysis of glutathione-dependent dehydroascorbate reductase from spinach chloroplasts

    E Mizohata, M Kumei, H Matsumura, T Shimaoka, C Miyake, T Inoue, A Yokota, Y Kai

    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY Vol. 57 No. 11 p. 1726-1728 2001/11 Research paper (scientific journal)

Misc. 21

  1. 二液混合シリアルフェムト秒結晶構造解析による酵素反応追跡

    南後恵理子, 南後恵理子, LUO Fangjia, LUO Fangjia, 木村哲就, 菅原道泰, 中根崇智, 鈴木守, 桝田哲哉, 溝端栄一, 登野健介, 登野健介, 岩田想, 岩田想

    日本結晶学会年会講演要旨集 Vol. 2021 2021

  2. 低免疫原性を持つストレプトアビジンとRI標識イミノビオチンを用いたプレターゲティング法の開発

    杉山暁, 杉山暁, 山次健三, 巽俊文, 鷲山幸信, 金井求, 児玉龍彦, 清水洋平, 溝端栄一, 井上豪

    核医学(Web) Vol. 57 No. Supplement 2020

  3. Reaction mechanism of nitrite reductase visualized by serial femtosecond crystallography

    Vol. 262 No. 5 p. 407-412 2017/07/29

    Publisher: 医歯薬出版
  4. 造血器型プロスタグランジンD合成酵素変異体V187Iの熱安定性

    門祐示, KANITTHAMNIYOM Pojchanun, 中村努, SUN Xin, 中山泰亮, 福田庸太, 溝端栄一, 裏出良博, 井上豪

    日本結晶学会年会講演要旨集 Vol. 2016 2016/11/17

  5. 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発

    中根崇智, 花島慎弥, 鈴木守, 鈴木守, 斎木悠, 林太一, 垣之内啓介, 垣之内啓介, 杉山成, 杉山成, 川竹悟史, 川竹悟史, 松岡茂, 松岡茂, 松森信明, 南後恵理子, 小林淳, 島村達郎, 木村香菜子, 森千寿, 国島直樹, 菅原道泰, 高久陽子, 井上茂之, 井上茂之, 桝田哲哉, 桝田哲哉, 保坂俊彰, 登野健介, 城地保昌, 亀島敬, 初井宇記, 矢橋牧名, 井上豪, 濡木理, 岩田想, 岩田想, 村田道雄, 村田道雄, 溝端栄一

    日本結晶学会年会講演要旨集 Vol. 2016 2016/11/17

  6. 高粘度結晶輸送媒体を利用したXFEL施設SACLAでの連続フェムト秒結晶構造解析

    菅原道泰, 鈴木守, 鈴木守, 桝田哲哉, 桝田哲哉, 井上茂之, 井上茂之, SONG Changyong, SONG Changyong, 中根崇智, 溝端栄一, 中津亨, 中津亨, 湯本史明, 南後恵理子, 登野健介, 沼田圭司, 岩田想, 岩田想

    日本結晶学会年会講演要旨集 Vol. 2016 2016/11

  7. エピレギュリン‐抗体複合体構造解析に基づく分子認識機構の解明

    門祐示, 溝端栄一, 長門石曉, 飯嶋真理子, 篠田恵子, 宮房孝光, 中山泰亮, 吉住拓真, 杉山暁, 川村猛, LEE Yougn‐Hun, 松村浩由, 土居洋文, 児玉龍彦, 柴崎芳一, 津本浩平, 井上豪

    日本蛋白質科学会年会プログラム・要旨集 Vol. 16th 2016/05/19

  8. Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography (vol 113, pg 2928, 2016)

    Yohta Fukuda, Ka Man Tse, Takanori Nakane, Toru Nakatsu, Mamoru Suzuki, Michihiro Sugahara, Shigeyuki Inoue, Tetsuya Masuda, Fumiaki Yumoto, Naohiro Matsugaki, Eriko Nango, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Changyong Song, Takaki Hatsui, Makina Yabashi, Osamu Nureki, Michael E. P. Murphy, Tsuyoshi Inoue, So Iwata, Eiichi Mizohata

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 113 No. 15 p. E2207-E2207 2016/04 Other

  9. X線自由電子レーザーを用いた新規タンパク質の立体構造決定

    山下恵太郎, 潘東青, 奥田智彦, 菅原道泰, 小段篤史, 山口知宏, 村井智洋, 溝端栄一, 鈴木守, 南後恵理子, 登野健介, 城地保昌, 亀島敬, 初井宇記, 矢橋牧名, 岩田想, 岩田想, 加藤博章, 加藤博章, 吾郷日出夫, 山本雅貴, 中津亨, 中津亨

    日本薬学会年会要旨集(CD-ROM) Vol. 136th 2016

  10. シリアル結晶学における重原子誘導体を用いた位相決定

    山下恵太郎, 潘東青, 長谷川和也, 菅原道泰, 村井智洋, 小段篤史, 溝端栄一, 鈴木守, 鈴木守, 桝田哲哉, 桝田哲哉, 平田邦生, 加藤博章, 加藤博章, 吾郷日出夫, 熊坂崇, 山本雅貴, 中津亨, 中津亨

    日本結晶学会年会講演要旨集 Vol. 2015 2015/10

  11. シリアルフェムト秒X線結晶構造解析のための試料調製方法

    田中智之, 菅原道泰, 山下鮎美, 小林淳, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名, 潘東青, 島村達郎, 溝端栄一, 岩田想, 南後恵理子

    日本蛋白質科学会年会プログラム・要旨集 Vol. 15th 2015/05/26

  12. 膜タンパク質研究基盤の構築に向けた合成リン脂質の利用

    杉山成, 斎木悠, 島田真典, 垣ノ内啓介, 垣ノ内啓介, 新山真由美, 新山真由美, 花島慎弥, 溝端栄一, 井上豪, 松森信明, 村田道雄, 村田道雄

    日本蛋白質科学会年会プログラム・要旨集 Vol. 15th 2015

  13. XFEL連続フェムト秒結晶構造解析:構造生物学の新時代

    溝端栄一, 福田庸太, 鈴木守, 鈴木守, 南後恵理子, 菅原道泰, 矢橋牧名, 登野健介, 城地保昌, 島村達郎, PANG Dongqing, CHAVAS Leonard M.G., 西澤知宏, 松村浩由, 林高史, 的場康幸, 杉山成, 村田道雄, 高木淳一, 井上豪, 岩田想

    日本蛋白質科学会年会プログラム・要旨集 Vol. 14th 2014

  14. 大腸がん特異抗原CCA1とその抗体Fab断片複合体のX線結晶構造解析

    門祐示, 溝端栄一, 篠田恵子, 中山泰亮, 吉住拓真, 李泳薫, 飯嶋真理子, 杉山暁, 土居洋文, 藤谷秀章, 津本浩平, 児玉龍彦, 柴崎芳一, 井上豪

    日本結晶学会年会講演要旨集 Vol. 2013 2013/10/12

  15. 熱力学的相互作用解析と分子動力学シミュレーションによる抗体の親和性向上のメカニズムの研究

    渡部貴大, 長門石曉, 山下雄史, 中山泰亮, 溝端栄一, 浜窪隆雄, 井上豪, 津本浩平, 児玉龍彦, 藤谷秀章

    日本分子生物学会年会プログラム・要旨集(Web) Vol. 36th 2013

  16. 創薬ターゲット蛋白質の迅速構造解析法の開発~SACLAにおけるシリアルフェムト秒X線結晶構造解析~

    南後恵理子, 鈴木守, 田中里枝, 登野健介, 城地保昌, 亀島敬, PARK Jaehyun, SONG Changyong, 初井宇記, 矢橋牧名, 潘東青, 小段篤史, 山口知宏, 中津亨, 加藤博章, 田中良樹, 寿野千代, 伊原健太郎, 豊田洋輔, 島村達郎, 溝端栄一, 北郷悠, 高木淳一, 石谷隆一郎, 濡木理, GALLAT Francois‐Xavier, 山田悠介, 松垣直宏, 湯本史明, CHAVAS Leonar, M. G, 岩田想

    日本結晶学会年会講演要旨集,2013,92 Vol. 2013 2013

  17. ブドウ由来UDP糖依存性グリコシルトランスフェラーゼの基質特異性の構造基盤の解明

    畑中聖加, 溝端栄一, 奥田卓馬, 中山泰亮, 堀川学, 中山亨, 小埜栄一郎, 井上豪

    日本結晶学会年会講演要旨集 Vol. 2012 2012/10/25

  18. An evolutionally conserved Lys122 is essential for function in Rhodospirillum rubrum bona fide RuBisCO and Bacillus subtilis RuBisCO-like protein

    Toshihiro Nakano, Hiroki Ashida, Eiichi Mizohata, Hiroyoshi Matsumura, Akiho Yokota

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 392 No. 2 p. 212-216 2010/02

  19. Promotion of Crystal Nucleation of Protein by Semi-Solid Agarose Gel

    Kana Tanabe, Mika Hirose, Ryota Murai, Shigeru Sugiyama, Noriko Shimizu, Mihoko Maruyama, Yoshinori Takahashi, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Yusuke Mori, Eiichi Mizohata, Tsuyoshi Inoue, Hiroyoshi Matsumura

    APPLIED PHYSICS EXPRESS Vol. 2 No. 12 2009/12

  20. Structure/function Relationships Especially About Fallover Phenomenon Of RuBisCO From Chlamydomonas reinhardtii

    Eiichi Mizohata

    Plant & Cell Physiology Vol. 41 2000

    Publisher: Japanese Society of Plant Physiologists
  21. アミノ酸置換による,フォールオーバー現象をはじめとするクラミドモナスRuBisCOの構造活性相関の解析

    溝端栄一

    Vol. 41 2000

Publications 5

  1. 膜タンパク質工学ハンドブック

    溝端栄一, 久保稔

    (株)エヌ・ティー・エス 2020 Scholarly book

  2. 膜タンパク質工学ハンドブック

    山下恵太郎, 溝端栄一

    (株)エヌ・ティー・エス 2020 Scholarly book

  3. 医学のあゆみ:生命現象を観る

    溝端栄一

    医歯薬出版株式会社 2017/07 Scholarly book

  4. タンパク質結晶の最前線(XFEL微結晶構造解析―構造生物学の新時代)

    溝端栄一, 鈴木守, 南後恵理子, 田中里枝, 井上豪, 岩田想

    シーエムシー出版 2013/12 Scholarly book

    ISBN: 9784781309293

  5. コンピューターで薬を創ろう

    安達宏昭, 井上豪, 奥野恭史, 片桐豊雅, 北島正人, 木下誉富, 坂田恒昭, 佐久間俊広, 志水隆一, 高田俊和, 高野和文, 仲西功, 福西快文, 松村浩由, 溝端栄一, 南方聖司, 水口賢司, 村上聡, 森勇介

    株式会社化学同人 2009/06 General book, introductory book for general audience

    ISBN: 4759803475

Presentations 19

  1. セサミン合成酵素CYP81QのX線結晶構造解析

    溝端栄一

    令和6年度 内外環境応答・代謝酵素研究会 2024/09/28

  2. X線自由電子レーザーを用いたタンパク質の動的結晶構造解析

    溝端栄一

    日本分光学会 関西支部 令和6年度 第1回講演会・見学会 2024/07/11

  3. 次世代抗体医薬品開発へのアプローチ

    溝端栄一

    SAKIGAKEシンポジウム2024「量子生体科学のフロンティア:先駆的アプローチと未来の展望」 2024/03/06

  4. CO2固定酵素 Rubiscoの動的構造解明への挑戦

    溝端栄一

    第22回日本蛋白質科学会年会 2022/06/08

  5. Damage-free protein observation and structure determination using X-ray free electron laser

    Eiichi Mizohata

    Pacifichem2020 2021/12/20

  6. 銅含有亜硝酸還元酵素の動的結晶構造解析

    溝端栄一

    第93回日本生化学会大会 2020/09/14

  7. ケージドCO2を用いた光化学制御によるRubiscoの時分割SFX計測システムの開発

    溝端栄一

    第1回 高速分子動画のための光化学制御研究会 2019/11

  8. X線自由電子レーザーを利用したタンパク質の動的構造解析

    溝端栄一

    学術調査官特別会議 2019/10

  9. X線自由電子レーザーを応用したタンパク質の動的結晶構造解析

    溝端栄一

    日本プロテオーム学会2019年大会, 第70回日本電気泳動学会総会 2019/07

  10. The high resolution molecular movie taken by X-ray free electron laser

    Eiichi Mizohata

    LSBM Symposium 2019. Yumoto Fujiya Hotel, Hakone 2019/04/03

  11. SACLAの先端XFEL技術を用いたタンパク質構造研究

    溝端栄一

    第6回バイオ関連化学シンポジウム若手フォーラム & 第33回生体機能関連化学部会若手フォーラム & 第5回バイオテクノロジー部会若手フォーラム 2018/09

  12. 膜蛋白質の構造決定を加速化する技術の動向 〜XFELを用いた実験的位相決定法〜

    溝端栄一

    第31回日本放射光学会年会・放射光科学合同シンポジウム 2018/01

  13. XFELを用いた構造生物学 〜膜蛋白質解析と酵素化学の新展開〜

    溝端栄一

    サントリーグローバルイノベーションセンター 2017/11

  14. Proteins in Serial Femtosecond Crystallography

    Eiichi Mizohata

    14th Conference of the Asian Crystallographic Association. Ta Quang Buu Library, Hanoi University of Science & Technology, Hanoi, Vietnam

  15. SACLAが拓く構造生物学の新時代

    溝端栄一

    LSBM Symposium 2016, "超分子構造の計算科学" 2016/05

  16. Structure-based protein engineering for cancer therapy

    Mizohata E, Kawato T, Nakayama T, Kado Y, Inoue T, Shimizu Y, Kanai M, Doi H, Sugiyama A, Hamakubo T, Kodama T

    3rd International Picobiology Institute Symposium: "Structural and biological studies on pathogenic and therapeutic targets", CAST, Hyogo, Japan

  17. Damage-free protein structure determination using X-ray free electron laser at SACLA

    Eiichi Mizohata

    Janelia Conference: “Challenges in Structural Biology”. Janelia Research Campus, Howard Hughes Medical Institute, USA 2015/10/17

  18. Damage-free structure determination by SFX at SACLA

    Eiichi Mizohata

    Workshop on serial femtosecond crystallography, SAXS, & Cryo-EM. Genentech Hall, Mission Bay Campus, University of California, San Francisco (UCSF), USA 2015/06/16

  19. セサミン合成酵素CYP81QのX線構造解析

    溝端 栄一, 米澤 涼, 近藤 賢真, 庄司 光男, 久保稔, 永野真吾, 原田英里砂, 村田純, 豊永宏美, 堀川学, 小埜栄一郎

    第57回 酸化反応討論会 2024/11/17

Works 1

  1. ビオラモ超音波ホモジナイザー

    アズワン株式会社, 溝端栄一, 共同開発

    2013 -

Industrial Property Rights 7

  1. 重原子化化合物、膜タンパク質の結晶化を促進するための組成物、および該組成物を用いた膜タンパク質の構造解析方法

    杉山成, 花島慎弥, 溝端栄一, 村田道雄, 井上豪, 斎木悠, 島田真典, 松森信明

    特許6579560

    登録日:2019/09/06

  2. ビオチン改変体、ストレプトアビジン変異体およびそれらの利用

    杉山暁, 土居洋文, 児玉龍彦, 井上豪, 溝端栄一, 川戸達也, 飯塚友洋, 金井求, 清水洋平, 山本倫広

    特許6178586

    登録日:2017/07/21

  3. ビオチン改変体、ストレプトアビジン変異体およびそれらの利用

    杉山暁, 土居洋文, 児玉龍彦, 井上豪, 溝端栄一, 川戸達矢, 飯塚友洋, 金井求, 清水洋平, 高須典明, 高津まり

    特許6096371

    登録日:2017/02/24

  4. ビオチン改変体、ストレプトアビジン変異体およびそれらの利用

    杉山暁, 土居洋文, 児玉龍彦, 井上豪, 溝端栄一, 川戸達也, 飯塚友洋, 金井求, 清水洋平, 山本倫広

    WO2014/129446

  5. Robo1に対する親和性を向上させた抗体及び高親和性抗体の分子設計方法

    浜窪隆雄, 津本浩平, 藤谷秀章, 山下雄史, 岩成宏子, 中木戸誠, 井上豪, 溝端栄一, 中山泰亮

    出願日:2013/11/19

  6. 膜タンパク質の安定化のための液体組成物および方法

    藤田恭子, 溝端栄一, 古谷祐詞

    出願日:2023/02/28

  7. ステビオール配糖体生合成変異酵素とその利用

    平井正良, 小埜栄一郎, 田中良和, 落合兼太郎, 溝端栄一

    出願日:2022/07/07

Social Activities 8

  • 日本・アジア青少年サイエンス交流事業 さくらサイエンスプラン, 『スパコン京・SPring-8/SACLA見学会』

    大阪大学

    2017 - 2018

  • 大阪大学「夢・化学21」「夏の研究室体験」(高校生対象)

    大阪大学

    2009 - 2018

  • 千里山環境セミナー, 『CO2とは何か?植物の光合成と気候変動』

    2024/03 -

  • 関西学術者セミナー, 『タンパク質の形が織りなす生命』

    2019/08 -

  • 大阪大学SEEDSプログラム2015・体感科学研究,『美しい蛋白質の結晶と構造の世界』

    大阪大学

    2015/09 -

  • 吹田コミュニティー集会,『がん治療研究の最前線』

    2011/11 -

  • 日本結晶学会講習会,タンパク質結晶学の基礎と実際,『ひとりでできるタンパク質の構造決定』

    日本結晶学会

    2009/11 -

  • 大阪大学Saturday Afternoon Physics 2009 (SAP2009),『最先端の物理を高校生に』

    大阪大学

    2009/10 -

Media Coverage 9

  1. X線波長でタンパク質結晶の新規構造解析に成功

    2017/09

  2. タンパク質の形を迅速に決定する手法で拓く、タンパク質構造ダイナミクス研究の新時代

    2016/12

  3. 膜たんぱく質解析 新手法 阪大などチーム 新薬開発 より速く

    2016/11

  4. 膜タンパク質の立体構造 阪大など迅速解明 「世界初」技術開発

    2016/11

  5. 阪大など、SACLAとSPring-8の技術融合で酵素反応の新機構解明

    2016/03

  6. たんぱく質結晶構造解析 試料1ケタ低減

    2014/11

  7. タンパク質解析 X線レーザーで新手法

    NHKテレビニュース

    2014/11

  8. 「夢の扉+」進行がんの薬をスパコンで設計する

    TBS系列テレビ

    2014/10

  9. MDADD 分子設計抗体プロジェクト成果報告映像

    2014/05

Academic Activities 11

  1. SAKIGAKEシンポジウム2024「量子生体科学のフロンティア:先駆的アプローチと未来の展望」

    溝端栄一(オーガナイザー)

    2024/03/06 - 2024/03/06

  2. 大阪大学経営企画オフィスURA部門,模擬面接審査員

    大阪大学

    2018 - 2019

  3. 第93回日本生化学会大会シンポジウム『タンパク質の高速分子動画撮影の汎用化に向けて』

    永野真吾・溝端栄一(オーガナイザー)

    2020/09 -

  4. 第1回 高速分子動画のための光化学制御研究会

    溝端栄一(オーガナイザー)

    2019/11 -

  5. 第18回 日本蛋白質科学会年会ワークショップ,『SACLAの先端技術がもたらす構造生物学研究のブレイクスルー』

    溝端栄一・南後恵理子(オーガナイザー)

    2018/06 -

  6. 大阪大学未来戦略機構第六部門(創薬基盤科学研究部門)シンポジウム,『環境と健康、創薬へ』

    大阪大学

    2017/01 -

  7. 第16回 日本蛋白質科学会年会ワークショップ,『SACLAが拓くシリアルフェムト秒結晶構造学の最前線』

    中津亨・溝端 栄一(オーガナイザー)

    2016/06 -

  8. 大阪大学未来戦略機構国際シンポジウム,『アカデミア発創薬を目指した戦略展開』

    大阪大学

    2015/03 -

  9. 世界結晶年(IYCr2014)記念講演会,『結晶の美しい世界と、私たちの未来』

    世界結晶年日本委員会

    2014/11 -

  10. SPring-8シンポジウム2012,『学術界、産業界におけるSPring-8の有効利用』

    SPring-8ユーザー協同体(SPRUC)・(公財)高輝度光科学研究センター ・(独)理化学研究所 (国)・大阪大学

    2012/08 -

  11. 日本結晶学会創立60周年記念イベント,60周年記念講演会・60周年記念シンポジウム

    日本結晶学会

    2010/12 -