FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity.

Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, Sho Matsui, Isao Matsui, Yoshitaka Isaka

Autophagy　Vol. 20　No. 3　p. 489-504　2024/03　Research paper (scientific journal)

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence

Mengying Cui, Koji Yamano, Kenichi Yamamoto, Hitomi Yamamoto-Imoto, Satoshi Minami, Takeshi Yamamoto, Sho Matsui, Tatsuya Kaminishi, Takayuki Shima, Monami Ogura, Megumi Tsuchiya, Kohei Nishino, Brian T. Layden, Hisakazu Kato, Hidesato Ogawa, Shinya Oki, Yukinori Okada, Yoshitaka Isaka, Hidetaka Kosako, Noriyuki Matsuda, Tamotsu Yoshimori, Shuhei Nakamura

Proceedings of the National Academy of Sciences (PNAS)　Vol. 121　No. 2　2024/01/09　Research paper (scientific journal)

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

Monami Ogura, Tatsuya Kaminishi, Takayuki Shima, Miku Torigata, Nao Bekku, Keisuke Tabata, Satoshi Minami, Kohei Nishino, Akiko Nezu, Maho Hamasaki, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

EMBO Reports　Vol. 24　No. 12　2023/12/06　Research paper (scientific journal)

Autophagy and kidney aging.

Satoshi Minami, Takeshi Yamamoto, Hitomi Yamamoto-Imoto, Yoshitaka Isaka, Maho Hamasaki

Progress in Biophysics and Molecular Biology　Vol. 179　p. 10-15　2023/03　Research paper (scientific journal)

TFEB-mediated lysosomal exocytosis alleviates high fat diet-induced lipotoxicity in the kidney.

Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

JCI insight　Vol. 8　No. 4　2023/02/22　Research paper (scientific journal)

Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

Nature Cell Biology　Vol. 24　No. 11　p. 1677-1679　2022/11　Research paper (scientific journal)

エンパグリフロジンは脂肪酸毒性軽減とオートファジー停滞解消を介して腎保護に働く

松井 翔, 山本 毅士, 高畠 義嗣, 高橋 篤史, 難波 倫子, 松田 潤, 南 聡, 酒井 晋介, 余西 洋明, 中村 隼, 前田 志穂美, 柳田 素子, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 221-221　2022/05

糖尿病性腎臓病におけるオートファジー不全と脂質代謝異常はフェロトーシス亢進を介して腎障害を悪化させる

松井 翔, 山本 毅士, 高畠 義嗣, 高橋 篤史, 難波 倫子, 松田 潤, 南 聡, 酒井 晋介, 余西 洋明, 中村 隼, 前田 志穂美, 新村 文男, 松阪 泰二, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 239-239　2022/05

TFEBは尿中へのリン脂質排出促進により肥満関連尿細管症に対して保護的に働く

中村 隼, 山本 毅士, 高畠 義嗣, 難波 倫子, 南 聡, 高橋 篤史, 松田 潤, 酒井 晋介, 前田 志穂美, 松井 翔, 新村 文男, 松阪 泰二, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 245-245　2022/05

MondoAはRubiconを介して尿細管のオートファジー活性を制御し、腎保護的に働く

前田 志穂美, 酒井 晋介, 高畠 義嗣, 高橋 篤史, 難波 倫子, 山本 毅士, 松田 潤, 南 聡, 中村 隼, 松井 翔, 新村 文男, 柳田 素子, 松阪 泰二, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 246-246　2022/05

近位尿細管におけるp53とオートファジーはSASP(老化関連分泌表現型)を協調的に抑制し腎老化を抑制する

南 聡, 山本 毅, 高畠 義嗣, 高橋 篤史, 難波 倫子, 松田 潤, 酒井 晋介, 中村 隼, 前田 志穂美, 松井 翔, 新村 文男, 松阪 泰二, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 253-253　2022/05

TRPC3/6阻害薬L-862はリポファジーを介した脂質代謝改善により急性腎障害を軽減する

山本 毅士, 余西 洋明, 高畠 義嗣, 松井 翔, 中村 隼, 難波 倫子, 高橋 篤史, 松田 潤, 南 聡, 酒井 晋介, 前田 志穂美, 永田 龍, 猪阪 善隆

日本腎臓学会誌　Vol. 64　No. 3　p. 260-260　2022/05

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis.

Hitomi Yamamoto-Imoto, Satoshi Minami, Tatsuya Shioda, Yurina Yamashita, Shinsuke Sakai, Shihomi Maeda, Takeshi Yamamoto, Shinya Oki, Mizuki Takashima, Tadashi Yamamuro, Kyosuke Yanagawa, Ryuya Edahiro, Miki Iwatani, Mizue So, Ayaka Tokumura, Toyofumi Abe, Ryoichi Imamura, Norio Nonomura, Yukinori Okada, Donald E Ayer, Hidesato Ogawa, Eiji Hara, Yoshitsugu Takabatake, Yoshitaka Isaka, Shuhei Nakamura, Tamotsu Yoshimori

Cell Reports　Vol. 38　No. 9　2022/03/01　Research paper (scientific journal)

Rubicon in Metabolic Diseases and Ageing.

Satoshi Minami, Shuhei Nakamura, Tamotsu Yoshimori

Frontiers in Cell and Developmental Biology　Vol. 9　2022/01/10　Research paper (scientific journal)

Therapeutic potential of Beclin1 for transition from AKI to CKD: autophagy-dependent and autophagy-independent functions.

Satoshi Minami, Shuhei Nakamura

Kidney International　Vol. 101　No. 1　p. 13-15　2022/01　Research paper (scientific journal)

Urinary mulberry bodies as a potential biomarker for early diagnosis and efficacy assessment of enzyme replacement therapy in Fabry nephropathy.

Hiroaki Yonishi, Tomoko Namba-Hamano, Takayuki Hamano, Masaki Hotta, Jun Nakamura, Shinsuke Sakai, Satoshi Minami, Takeshi Yamamoto, Atsushi Takahashi, Wataru Kobayashi, Ikuhiro Maeda, Yoh Hidaka, Yoshitsugu Takabatake, Norio Sakai, Yoshitaka Isaka

Nephrology Dialysis Transplantation (NDT)　Vol. 37　No. 1　p. 53-62　2021/12/31　Research paper (scientific journal)

Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.

Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Tomonori Kimura, Isao Matsui, Jun-Ya Kaimori, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka

Autophagy　Vol. 17　No. 7　p. 1700-1713　2021/07　Research paper (scientific journal)

THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation.

Toshiharu Fujita, Sayaka Kubo, Tatsuya Shioda, Ayaka Tokumura, Satoshi Minami, Megumi Tsuchiya, Yoshitaka Isaka, Hidesato Ogawa, Maho Hamasaki, Li Yu, Tamotsu Yoshimori, Shuhei Nakamura

Journal of Cell Science　Vol. 134　No. 6　2021/03/22　Research paper (scientific journal)

Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin.

Yuri Tsugawa-Shimizu, Yuya Fujishima, Shunbun Kita, Satoshi Minami, Taka-Aki Sakaue, Yuto Nakamura, Tomonori Okita, Yusuke Kawachi, Shiro Fukada, Tomoko Namba-Hamano, Yoshitsugu Takabatake, Yoshitaka Isaka, Hitoshi Nishizawa, Barbara Ranscht, Norikazu Maeda, Iichiro Shimomura

American Journal of Physiology. Endocrinology and Metabolism　Vol. 320　No. 2　p. E179-E190　2021/02/01　Research paper (scientific journal)

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

Nature Cell Biology　Vol. 22　No. 10　p. 1252-1263　2020/10　Research paper (scientific journal)

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.

Jun Matsuda, Atsushi Takahashi, Yoshitsugu Takabatake, Shinsuke Sakai, Satoshi Minami, Takeshi Yamamoto, Ryuta Fujimura, Tomoko Namba-Hamano, Hiroaki Yonishi, Jun Nakamura, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Tamotsu Yoshimori, Yoshitaka Isaka

Autophagy　Vol. 16　No. 10　p. 1889-1904　2020/10　Research paper (scientific journal)

Autophagy protects kidney from phosphate-induced mitochondrial injury.

Ryuta Fujimura, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Satoshi Minami, Shinsuke Sakai, Jun Matsuda, Atsushi Hesaka, Hiroaki Yonishi, Jun Nakamura, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka

Biochemical and Biophysical Research Communications　Vol. 524　No. 3　p. 636-642　2020/04/09　Research paper (scientific journal)

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes.

Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Satoshi Minami, Ryuta Fujimura, Hiroaki Yonishi, Jun Matsuda, Atsushi Hesaka, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka

Journal of the American Society of Nephrology (JASN)　Vol. 30　No. 6　p. 929-945　2019/06　Research paper (scientific journal)

Suppression of autophagic activity by Rubicon is a signature of aging.

Shuhei Nakamura, Masaki Oba, Mari Suzuki, Atsushi Takahashi, Tadashi Yamamuro, Mari Fujiwara, Kensuke Ikenaka, Satoshi Minami, Namine Tabata, Kenichi Yamamoto, Sayaka Kubo, Ayaka Tokumura, Kanako Akamatsu, Yumi Miyazaki, Tsuyoshi Kawabata, Maho Hamasaki, Koji Fukui, Kazunori Sango, Yoshihisa Watanabe, Yoshitsugu Takabatake, Tomoya S Kitajima, Yukinori Okada, Hideki Mochizuki, Yoshitaka Isaka, Adam Antebi, Tamotsu Yoshimori

Nature Communications　Vol. 10　No. 1　2019/02/19　Research paper (scientific journal)

Tolvaptan promotes urinary excretion of sodium and urea: a retrospective cohort study.

Satoshi Minami, Takayuki Hamano, Hirotsugu Iwatani, Masayuki Mizui, Yoshiki Kimura, Yoshitaka Isaka

Clinical and Experimental Nephrology　Vol. 22　No. 3　p. 550-561　2018/06　Research paper (scientific journal)

Antioxidant role of autophagy in maintaining the integrity of glomerular capillaries.

Jun Matsuda, Tomoko Namba, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Takeshi Yamamoto, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Yoko Fukushima, Keiko Matsui, Tomoyoshi Soga, Yoshitaka Isaka

Autophagy　Vol. 14　No. 1　p. 53-65　2018　Research paper (scientific journal)

Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation.

Satoshi Minami, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Yoshitaka Isaka

Autophagy　Vol. 13　No. 10　p. 1629-1647　2017/10/03　Research paper (scientific journal)

High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney.

Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomonori Kimura, Tomoko Namba, Jun Matsuda, Satoshi Minami, Jun-Ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka

Journal of the American Society of Nephrology (JASN)　Vol. 28　No. 5　p. 1534-1551　2017/05　Research paper (scientific journal)

Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules.

Atsushi Takahashi, Yoshitsugu Takabatake, Tomonori Kimura, Ikuko Maejima, Tomoko Namba, Takeshi Yamamoto, Jun Matsuda, Satoshi Minami, Jun-Ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Tamotsu Yoshimori, Yoshitaka Isaka

Diabetes　Vol. 66　No. 5　p. 1359-1372　2017/05　Research paper (scientific journal)

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule.

Takeshi Yamamoto, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Satoshi Minami, Jun-Ya Kaimori, Isao Matsui, Harumi Kitamura, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka, Hiromi Rakugi

Autophagy　Vol. 12　No. 5　p. 801-813　2016/05/03　Research paper (scientific journal)

[Pneumonia in maintenance hemodialysis patients: detection rate of causative organisms in sputum varies with time of sampling and quality].

Koichi Sasaki, Satoshi Yamaguchi, Eriko Iwahashi, Taku Fujimoto, Satoshi Minami, Hiromi Rakugi, Yoshitaka Isaka, Kenji Yokoyama

Nihon Jinzo Gakkai Shi　Vol. 56　No. 4　p. 524-531　2014

血液透析にてコントロール困難であった収縮性心膜炎による心不全の一例

藤本 拓, 岩橋 恵理子, 酒井 晋介, 南 聡, 岡 樹史, 佐々木 公一, 藤田 芳正, 横山 建二

大阪透析研究会会誌　Vol. 31　No. 2　p. 247-247　2013/09

血液透析導入期の透析中血圧低下と長期予後の検討

佐々木 公一, 酒井 晋介, 岩橋 恵理子, 藤本 拓, 南 聡, 岡 樹史, 藤田 芳正, 林 晃正, 横山 建二

日本腎臓学会誌　Vol. 55　No. 3　p. 324-324　2013/04

血液透析導入期における血清ferritin値と生命予後についての検討

南 聡, 岩橋 恵理子, 酒井 晋介, 藤本 拓, 岡 樹史, 佐々木 公一, 藤田 芳正, 横山 建二

日本腎臓学会誌　Vol. 55　No. 3　p. 324-324　2013/04

尿路感染症を契機としてAKI・著しい代謝性アシドーシスを来した1例

岩橋 恵理子, 酒井 晋介, 藤本 拓, 南 聡, 岡 樹史, 佐々木 公一, 横山 建二

大阪透析研究会会誌　Vol. 31　No. 1　p. 107-107　2013/03

25年来の強皮症の経過中にループス腎炎を発症したoverlap症候群の一例

南 聡, 酒井 晋介, 岩橋 恵理子, 藤本 拓, 岡 樹史, 佐々木 公一, 横山 建二

日本腎臓学会誌　Vol. 54　No. 6　p. 890-890　2012/08