顔写真

PHOTO

Ookouchi Yoshifumi
大河内 善史
Ookouchi Yoshifumi
大河内 善史
Graduate School of Medicine Division of Medicine, Associate Professor

Research History 5

  1. 2020/05 - Present
    大阪大学大学院医学系研究科 統合生理学 准教授

  2. 2008/07 - 2020/04
    Osaka University Graduate School of Medicine

  3. 2012/06 - 2013/03
    Sickkids Hospital in Toronto, Canada cell biology (Sergio Grinstein lab)

  4. 2008/04 - 2008/06
    Osaka University Graduate School of Medicine

  5. 2005/12 - 2008/03
    岡崎統合バイオサイエンスセンター 非常勤研究員

Education 3

  1. Nagoya University Graduate School of Science

    2000/04 - 2005/11

  2. Nagoya University

    1998/04 - 2000/03

  3. Hokkaido University

    1992/04 - 1998/03

Professional Memberships 3

  1. Biophysical Society

  2. 日本生化学会

  3. THE PHYSIOLOGICAL SOCIETY OF JAPAN

Research Areas 2

  1. Life sciences / Molecular biology /

  2. Life sciences / Physiology /

Papers 42

  1. Dimerization is required for the glycosylation of S1-S2 linker of sea urchin voltage-gated proton channel Hv1

    Yoshifumi Okochi, Yuka Jinno, Yasushi Okamura

    Biophysical Journal 2024/07 Research paper (scientific journal)

    Publisher: Elsevier BV
  2. Dimerization of sea urchin Hv1 voltage-gated proton channel is required for its own glycosylation.

    Okochi Y., Jinno Y., Okamura Y.

    The Journal of Physiological Sciences Vol. 73 p. 95-95 2023/03

  3. Role of K364 next to the active site cysteine in voltage-dependent phosphatase activity of Ci-VSP.

    Ian Costa Paixao, Natsuki Mizutani, Makoto Matsuda, Rizki Tsari Andriani, Takafumi Kawai, Atsushi Nakagawa, Yoshifumi Okochi, Yasushi Okamura

    Biophysical journal 2023/01/19 Research paper (scientific journal)

  4. Toward understanding of transport mechanism of SLC34 Na+/Pi cotransporter

    Okochi Y., Zhou J., Mizutani N., Shiozaki Y., Segawa H., Okamura Y.

    The Journal of Physiological Sciences Vol. 72 p. S53-S53 2022/03

  5. Analysis of transport mechanism of SLC34 Na+/Pi cotransporter

    The Journal of Physiological Sciences Vol. 84 No. 1 p. 33-33 2022/02

    Publisher:
  6. Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels

    Yoshifumi Okochi, Yasushi Okamura

    International Journal of Molecular Sciences Vol. 22 No. 5 p. 2620-2620 2021/03/05 Research paper (scientific journal)

    Publisher: MDPI AG
  7. Regulation of hepatic oxidative stress by voltage-gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism.

    Takafumi Kawai, Kento Kayama, Shoki Tatsumi, Sharmin Akter, Nana Miyawaki, Yoshifumi Okochi, Manabu Abe, Kenji Sakimura, Hiroyasu Yamamoto, Shinji Kihara, Yasushi Okamura

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology Vol. 34 No. 12 p. 15805-15821 2020/12 Research paper (scientific journal)

  8. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

    Taiki Sakaguchi, Ryu Okumura, Chisato Ono, Daisuke Okuzaki, Takafumi Kawai, Yoshifumi Okochi, Natsuko Tanimura, Mari Murakami, Hisako Kayama, Eiji Umemoto, Hidetaka Kioka, Tomohito Ohtani, Yasushi Sakata, Kensuke Miyake, Yasushi Okamura, Yoshihiro Baba, Kiyoshi Takeda

    Cell reports Vol. 31 No. 10 p. 107755-107755 2020/06/09 Research paper (scientific journal)

  9. Hv1/VSOP regulates neutrophil directional migration and ERK activity by tuning ROS production

    Yoshifumi Okochi, Eiji Umemoto, Yasushi Okamura

    Journal of Leukocyte Biology Vol. 107 No. 5 p. 819-831 2020/05 Research paper (scientific journal)

    Publisher: Wiley
  10. Establishment of a method measuring membrane potential in phagosomes

    Okochi Y., Tsutsi H., Okamura Y.

    The Journal of Physiological Sciences Vol. 70 p. S118-S118 2020/03

  11. Distinct functional properties of two electrogenic isoforms of the SLC 34 Na‐Pi cotransporter

    Natsuki Mizutani, Yoshifumi Okochi, Yasushi Okamura

    Physiological Reports Vol. 7 No. 14 2019/07 Research paper (scientific journal)

    Publisher: Wiley
  12. Analysis of membrane potential of phagosome in phagocytes

    Yoshifumi Okochi, Hidekazu Tsutsui, Yasushi Okamura

    2019/06 Research paper (other academic)

  13. The comparison of sensitivity between NaPi-IIa and NaPi-IIb activity to phosphoinositides

    Mizutani N., Okochi Y., Okamura Y.

    Vol. 69 p. S171-S171 2019/03

  14. Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals.

    Yasushi Okamura, Yoshifumi Okochi

    Proceedings of the Japan Academy. Series B, Physical and biological sciences Vol. 95 No. 3 p. 111-135 2019/03 Research paper (scientific journal)

  15. Hv1/VSOP voltage-gated proton channel inhibits migration in response to fMLF in neutrophils

    The Journal of Physiological Sciences Vol. 69 p. S31-, S31 2019/03 Research paper (international conference proceedings)

  16. Measurement o f membrane potential change in phagosome of phagocytes

    Yoshifumi Okochi, Hidekazu Tsutsui, Yasushi Okamura

    The Journal of Physiological Sciences Vol. 68 p. S74-S74 2018/03 Research paper (other academic)

  17. Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production

    Takafumi Kawai, Yoshifumi Okochi, Tomohiko Ozaki, Yoshio Imura, Schuichi Koizumi, Maya Yamazaki, Manabu Abe, Kenji Sakimura, Toshihide Yarnashitat, Yasushi Okamura

    JOURNAL OF NEUROCHEMISTRY Vol. 142 No. 5 p. 686-699 2017/09 Research paper (scientific journal)

  18. Hv1/VSOP inhibits chemotaxis behavior toward fMLP in mouse neutrophils

    The Journal of Physiological Sciences Vol. 67 p. S137-S137 2017/03 Research paper (other academic)

  19. The role of voltage-gated proton channel Hv1 in neutrophil chemotaxis

    Yoshifumi Okochi, Yasushi Okamura

    2016/03 Research paper (other academic)

  20. The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release

    Yoshifumi Okochi, Yasuaki Aratani, Hibret A. Adissu, Nana Miyawaki, Mari Sasaki, Kazuo Suzuki, Yasushi Okamura

    JOURNAL OF LEUKOCYTE BIOLOGY Vol. 99 No. 1 p. 7-19 2016/01 Research paper (scientific journal)

  21. X-ray crystal structure of voltage-gated proton channel

    Kohei Takeshita, Souhei Sakata, Eiki Yamashita, Yuichiro Fujiwara, Akira Kawanabe, Tatsuki Kurokawa, Yoshifumi Okochi, Makoto Matsuda, Hirotaka Narita, Yasushi Okamura, Atsushi Nakagawa

    NATURE STRUCTURAL & MOLECULAR BIOLOGY Vol. 21 No. 4 p. 352-U170 2014/04 Research paper (scientific journal)

  22. Functional diversity of voltage-sensing phosphatases in two urodele amphibians

    Joshua Mutua, Yuka Jinno, Souhei Sakata, Yoshifumi Okochi, Shuichi Ueno, Hidekazu Tsutsui, Takafumi Kawai, Yasuhiro Iwao, Yasushi Okamura

    Physiological Reports Vol. 2 No. 7 2014 Research paper (scientific journal)

    Publisher: American Physiological Society
  23. Autoimmune disorder phenotypes in Hvcn1-deficient mice

    Mari Sasaki, Akihiro Tojo, Yoshifumi Okochi, Nana Miyawaki, Daisuke Kamimura, Akihito Yamaguchi, Masaaki Murakami, Yasushi Okamura

    BIOCHEMICAL JOURNAL Vol. 450 p. 295-301 2013/03 Research paper (scientific journal)

  24. Subcellular localization of voltage-gated proton channels in primary cultured microglia

    Takafumi Kawai, Yoshio Imura, Shuichi Koizumi, Yoshifumi Okochi, Kenji Sakimura, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 63 p. S243-S243 2013

  25. Autoimmune disorder phenotypes in HVCN1 gene deficient mice

    Mari Sasaki, Akihiro Tojo, Yoshifumi Okochi, Nana Miyawaki, Daisuke Kamimura, Akihito Yamaguchi, Masaaki Murakami, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 63 p. S192-S192 2013

  26. Physiological Genomics of Amphibian VSP : A Potential Molecular Mechanism of Electrical Block of Fertilization in Vertebrates

    Joshua Mutunga Mutua, Yuka Jinno, Shuichi Ueno, Souhei Sakata, Yoshifumi Okochi, Hidekazu Tsutsui, Yasuhiro Iwao, Laurinda Jaffe, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 63 p. S251-S251 2013

  27. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1

    Yuichiro Fujiwara, Tatsuki Kurokawa, Kohei Takeshita, Megumi Kobayashi, Yoshifumi Okochi, Atsushi Nakagawa, Yasushi Okamura

    NATURE COMMUNICATIONS Vol. 3 2012/05 Research paper (scientific journal)

  28. Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Yuki Tsukada, Atsushi Kuhara, Ikue Mori

    PLOS GENETICS Vol. 7 No. 5 2011/05 Research paper (scientific journal)

  29. Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans

    Noriyuki Ohnishi, Atsushi Kuhara, Fumiya Nakamura, Yoshifumi Okochi, Ikue Mori

    EMBO JOURNAL Vol. 30 No. 7 p. 1376-1388 2011/04 Research paper (scientific journal)

  30. Reversal of Salt Preference Is Directed by the Insulin/PI3K and G(q)/PKC Signaling in Caenorhabditis elegans

    Takeshi Adachi, Hirofumi Kunitomo, Masahiro Tomioka, Hayao Ohno, Yoshifumi Okochi, Ikue Mori, Yuichi Iino

    GENETICS Vol. 186 No. 4 p. 1309-U383 2010/12 Research paper (scientific journal)

  31. Functionality of the voltage-gated proton channel truncated in S4

    Souhei Sakata, Tatsuki Kurokawa, Morten H. H. Norholm, Masahiro Takagi, Yoshifumi Okochi, Gunnar von Heijne, Yasushi Okamura

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 107 No. 5 p. 2313-2318 2010/02 Research paper (scientific journal)

  32. VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

    Antoun El Chemaly, Yoshifumi Okochi, Mari Sasaki, Serge Arnaudeau, Yasushi Okamura, Nicolas Demaurex

    Journal of Experimental Medicine Vol. 207 No. 1 p. 129-139 2010/01/18 Research paper (scientific journal)

  33. Membrane Topology of S4 of the Mouse Voltage-Gated Proton Channel

    Souhei Sakata, Tatsuki Kurokawa, Morten Norholm, Masahiro Takagi, Yoshifumi Okochi, Gunnar von Heijne, Yasushi Okamura

    BIOPHYSICAL JOURNAL Vol. 98 No. 3 p. 539A-539A 2010/01 Research paper (scientific journal)

  34. VSOP/Hv1 Proton Channels Sustain Superoxide Production, Calcium Entry, and Cell Migration by Limiting the Depolarization and Acidification of Activated Neutrophils

    Antoun El Chemaly, Yoshifumi Okochi, Mari Sasaki, Serge Arnaudeau, Yasushi Okamura, Nicolas Demaurex

    BIOPHYSICAL JOURNAL Vol. 98 No. 3 p. 709A-709A 2010/01 Research paper (international conference proceedings)

  35. Voltage-gated proton channel is expressed on phagosomes

    Yoshifumi Okochi, Mari Sasaki, Hirohide Iwasaki, Yasushi Okamura

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 382 No. 2 p. 274-279 2009/05 Research paper (scientific journal)

  36. VSOP Protein Lacking the C-terminal Half of S4-like Segment Retains Proton Permeation

    黒川竜紀, 高木正浩, 坂田宗平, 大河内善史, 岡村康司

    Biophys. J. Supplement. 2009/03 Research paper (international conference proceedings)

  37. Hv1 PROTON CHANNELS SUSTAIN SUPEROXIDE PRODUCTION AND CALCIUM SIGNALING IN NEUTROPHILS

    Antoun El Chemaly, Yoshifumi Okochi, Mari Sasaki, Serge Arnaudeau, Yasushi Okamura, Nicolas Demaurex

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 59 p. 401-401 2009 Research paper (international conference proceedings)

  38. Voltage-gated proton channel is expressed on phagosome

    Yoshifumi Okochi, Mari Sasaki, Yasushi Okamura

    NEUROSCIENCE RESEARCH Vol. 65 p. S73-S73 2009 Research paper (scientific journal)

  39. Multimeric nature of voltage-gated proton channels

    Hans P. Koch, Tatsuki Kurokawa, Yoshifumi Okochi, Mari Sasaki, Yasushi Okamura, H. Peter Larsson

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 105 No. 26 p. 9111-9116 2008/07 Research paper (scientific journal)

  40. Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases

    Md. Israil Hossain, Hirohide Iwasaki, Yoshifumi Okochi, Mohamed Chahine, Shinichi Higashijima, Kuniaki Nagayama, Yasushi Okamura

    JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 283 No. 26 p. 18248-18259 2008/06 Research paper (scientific journal)

  41. Diverse regulation of sensory signaling by C-elegans nPKC-epsilon/eta TTX-4

    Y Okochi, KD Kimura, A Ohta, Mori, I

    EMBO JOURNAL Vol. 24 No. 12 p. 2127-2137 2005/06 Research paper (scientific journal)

  42. Antimicrobial peptide of Korean native goat lactoferrin and identification of the part essential for this activity

    M Kimura, MS Nam, Y Ohkouchi, H Kumura, K Shimazaki, DY Yu

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 268 No. 2 p. 333-336 2000/02 Research paper (scientific journal)

Misc. 20

  1. Physiological genomics of voltage-sensing phosphatases

    Yasushi Okamura, Tatsuki Kurokawa, Souhei Sakata, Ikuko Fujii-Taira, Yoshifumi Okochi, Shinji Yamaguchi, Michio Ogasawara, Koichi J. Homma

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 60 p. S69-S69 2010 Research paper, summary (international conference)

  2. The role of voltage-gated proton channel, VSOP, in phagocytes

    Yoshifumi Okochi, Tsukase Kawahara, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 60 p. S123-S123 2010 Research paper, summary (international conference)

  3. ANALYSES OF VOLTAGE-GATED PROTON CHANNEL, VSOP, IN PHAGOCYTES

    Yoshifumi Okochi, Mari Sasaki, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 59 p. 400-400 2009 Research paper, summary (international conference)

  4. Studies on neuronal function of a novel and conserved protein TTX-8

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Yuki Tsukada, Atsushi Kuhara, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 65 p. S216-S216 2009 Research paper, summary (international conference)

  5. THE ROLE OF C-TERMINAL CYTOPLASMIC REGIONS IN DIMERIZATION OF VOLTAGE-GATED PROTON CHANNEL

    Tatsuki Kurokawa, Yoshifumi Okochi, Yasushi Okamura

    JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 59 p. 400-400 2009 Research paper, summary (international conference)

  6. 線虫C.elegansの味覚神経ASERによる塩走性学習の制御とその分子メカニズム

    ADACHI TAKESHI, KUNITOMO HIROFUMI, TOMIOKA MASAHIRO, OKOUCHI YOSHIFUMI, MORI IKUE, IINO YUICHI

    日本分子生物学会年会講演要旨集 Vol. 32nd No. Vol.3 2009

  7. Studies on neuronal function of a novel and conserved protein TTX-8

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Masatoshi Okumura, Ikue Mori

    GENES & GENETIC SYSTEMS Vol. 83 No. 6 p. 489-489 2008/12 Research paper, summary (international conference)

  8. Analysis of glutamate-mediated synaptic transduction through thermotaxis neural circuit of C. elegans

    Noriyuki Ohnishi, Atsushi Kuhara, Masatoshi Okumura, Yoshifumi Okochi, Hitoshi Inada, Ikue Mori

    GENES & GENETIC SYSTEMS Vol. 83 No. 6 p. 490-490 2008/12 Research paper, summary (international conference)

  9. イオンチャネルの"機能する姿"の解明に向けて 電位依存性プロトンチャネルの動作機構(Molecular mechanisms of voltage-gated proton channel)

    黒川 竜紀, コッホ・ハンス, 高木 正浩, 大河内 善史, 佐々木 真理, ラーソン・ピーター, 岡村 康司

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 Vol. 81回・31回 p. 4S21-2 2008/11

    Publisher: (公社)日本生化学会
  10. Analysis of genes interacting with the insulin-like signaling pathway, which regulates salt chemotaxis learning in C-elegans

    Takeshi Adachi, Masahiro Tomioka, Hirofumi Kunitomo, Yoshifumi Okochi, Ikue Mori, Yuichi Lino

    NEUROSCIENCE RESEARCH Vol. 61 p. S194-S194 2008 Research paper, summary (international conference)

  11. Dimeric nature of voltage-gated proton channel, VSOP

    Tatsuki Kurokawa, Hans P. Koch, Yoshifumi Okochi, Mari Sasaki, Peter H. Larsson, Yasushi Okamura

    NEUROSCIENCE RESEARCH Vol. 61 p. S73-S73 2008 Research paper, summary (international conference)

  12. Studies on neuronal function of a novel and conserved protein TTX-8

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Masatoshi Okumura, ryo Takano, Atsushi Kuhara, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 61 p. S183-S183 2008 Research paper, summary (international conference)

  13. Analysis of a voltage-gated proton channel, VSOP in microglia

    Yoshifumi Okochi, Makoto Sawada, Mari Sasaki, Hirohide Iwasaki, Yasushi Okamura

    NEUROSCIENCE RESEARCH Vol. 58 p. S187-S187 2007 Research paper, summary (international conference)

  14. A suppressor screen for genes that regulate salt chemotaxis learning in C-elegans

    Takeshi Adachi, Masahiro Tomioka, Hirofumi Kunitomo, Yoshifumi Okochi, Ikue Mori, Yuichi Iino

    NEUROSCIENCE RESEARCH Vol. 58 p. S227-S227 2007 Research paper, summary (international conference)

  15. Analysis of glutamate-mediated control of head motor neurons through thermotaxis neural circuit

    Noriyuki Ohnishi, Atsushi Kuhara, Masatoshi Okumura, Yoshifumi Okochi, Hitoshi Inada, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 58 p. S136-S136 2007 Research paper, summary (international conference)

  16. Studies on neuronal function of a novel and conserved protein TTX-8

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Masatoshi Okumura, Ryo Takano, Atsushi Kuhara, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 58 p. S226-S226 2007 Research paper, summary (international conference)

  17. Analysis of ttx-8: Novel thermotaxis gene conserved among various organisms

    Akiko Miyara, Akane Ohta, Yoshifumi Okochi, Masatoshi Okumura, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 55 p. S95-S95 2006 Research paper, summary (international conference)

  18. Glutamate-mediated neurotransmission through VGLUT is required for thermo sensory transduction

    Noriyuki Ohnishi, Atsushi Kuhara, Masatoshi Okumura, Yoshifumi Okochi, Hitoshi Inada, Ikue Mori

    NEUROSCIENCE RESEARCH Vol. 55 p. S76-S76 2006 Research paper, summary (international conference)

  19. 線虫 C.elegans の神経回路におけるグルタミン酸を介した温度情報伝達機構の解析

    大西憲幸, 久原篤, 奥村将年, 大河内善史, 稲田仁, 森郁恵

    日本分子生物学会年会講演要旨集 Vol. 28th 2005

  20. 線虫C.elegansの温度走性行動は小胞性グルタミン酸輸送体EAT-4により制御される

    大西憲幸, 久原篤, 奥村将年, 大河内善史, 稲田仁, 森郁恵

    日本分子生物学会年会プログラム・講演要旨集 Vol. 27th 2004

Publications 7

  1. ホスフォイノシチドによるチャネル・トランスポーターの制御

    岡村康司, 水谷夏希, 大河内善史

    2019/06

  2. ガイトン生理学

    大河内善史

    Elsevier Japan 2018/03

  3. 炎症と免疫2017年7月号「炎症抑制に関わる電位依存性プロトンチャネルHv1/VSOPの機能(リポクオリティによる膜タンパク質の機能制御と炎症・免疫)」

    大河内善史, 川鍋陽, 岡村康司

    先端医学社 2017/06 Scholarly book

  4. リポクオリティによる膜タンパク質の機能制御と炎症・免疫~炎症抑制にかかわる電位依存性プロトンチャネルHv1/VSOPの機能

    大河内善史, 川鍋陽, 岡村康司

    先端医学社 2017/06

  5. 実験医学プロテインキナーゼ「線虫の温度走性行動の解析から明らかになったPKCの新たな役割

    大河内善史, 森郁恵

    羊土社 2006/06

  6. 蛋白質核酸酵素 神経回路の機能発現のメカニズム「線虫学習行動の分子遺伝学:温度走性」

    奥村将年, 大河内善史, 森郁恵

    共立出版 2004/02 Scholarly book

  7. 神経回路の機能発現のメカニズム「線虫学習行動の分子遺伝学:温度走性」

    奥村将年, 大河内善史, 森郁恵

    共立出版 2004/02

Presentations 41

  1. Role of dimerization of Hv1/VSOP voltage-gated proton channel in ER

    Yoshifumi Okochi, Yasushi Okamura

    2025/03/19

  2. 遺伝子組み替えマウスを用いた海馬の軸索起始部における電位依存性ナトリウムチャネルNav1.6のターンオーバーの解析

    山元康平, 大河内善史, 好岡大輔, 阿部学, 崎村健司, 岡村康司

    第97回日本生化学会大会 2024/11/07

  3. Photocaged amino acid method elucidates the potency of individual positively-charged residues in PIP2-dependency of the Kir2.1 inwardly rectifying potassium channel

    Junxian Zhou, Natsuki Mizutani, Kohei Yamamoto, Yoshifumi Okochi, Yasushi Okamura

    IUPAB2024 2024/06

  4. Analysis of sodium channel turnover using mice that can distinguish between old and new Nav1.6 protein ~Toward understanding mechanism of homeostasis of neuronal function~

    2024/03/28

  5. 網膜神経節細胞に着目した色変更型Nav1.6-Flexマウスを用いたNav1.6タンパクのターンオーバーの解析

    大河内善史, 山元康平, 好岡大輔, 阿部学, 﨑村建司, 岡村康司

    先端モデル動物支援プラットフォーム(AdAMS) 2024/02/09

  6. Nav1.6タンパクのターンオーバーを可視化するマウスを用いた神経細胞機能 維持機構の解明

    大河内善史, 山元康平, 好岡大輔, 阿部学, 﨑村建司, 岡村康司

    UNG研究会 2024/01/27

  7. 電位依存性プロトンチャネルHv1の2量体化はERでの滞在時間を延ばす

    大河内善史, 神野有香, 岡村康司

    第96回日本生化学会大会 2023/10/31

  8. The effect of Vitamin D3 on the sodium phosphate cotransporter family SLC34

    Junxian Zhou, Yoshifumi Okochi, Yasushi Okamura

    The 100th Anniversary Annual Meeting of The Physiological Society of Japan 2023/03/14

  9. 色変更型Nav1.6-Flexマウスを用いたNav1.6タンパクのターンオーバーの解析

    大河内善史, 好岡大輔, 阿部学, 﨑村建司, 岡村康司

    先端モデル動物支援プラットフォーム(AdAMS) 2022年度成果発表会

  10. 電位依存性プロトンチャネルHv1の2量体化はERの滞在時間を延ばす

    大河内善史, 神野由香, 岡村康司, 岡村康司

    日本生化学会大会 2023

  11. Understanding the transport mechanisms of the Na+/Pi cotransporter NaPi-IIc/SLC34A3

    Junxian Zhou, Natsuki Mizutani, Yuji Shiozaki, Hiroko Segawa, Yasushi Okamura, Yoshifumi Okochi

    IUPS2022

  12. Understanding of transport mechanism of NaPi-IIc (SLC34A3) Na+/Pi cotransporter

    Junxian Zhou, Natsuki Mizutani, Yuji Shiozaki, Hiroko Segawa, Yasushi Okamura, Yoshifumi Okochi

    2022/05

  13. Analysis of transport mechanism of SLC34 Na+/Pi cotransporter

    2022/03/16

  14. Toward understanding of transport mechanism of SLC34 Na+/Pi cotransporter

    2022/03/16

  15. 腎臓で機能するNa-Pi cotransporter SLC34A3のイオン輸送の仕組みの解明

    周俊先, 大河内善史, 水谷夏希, 塩﨑雄治, 瀬川博子, 岡村康司

    第 113 回近畿生理学談話会 2021/11/27

  16. Method of measuring the membrane potential of phagosomes by optical imaging

    Yoshifumi Okochi, Hidekazu Tsutsui, Yasushi Okamura

    74th Annual Meeting and Symposium of the Society of General Physiologists Ion Channels & Transporters in Immunity, Inflammation and Antitumor Immunity 2021/09/25

  17. Visualizing phagosomal membrane potential and investigating the roles in macrophages

    2021/03/30

  18. 細胞内膜の膜電位を可視化する:貪食細胞の食胞膜電位計測法の確立

    大河内善史, 筒井秀和, 岡村康司

    生理学研究所研究会「イオンチャネルと生体膜のダイナミズム:構造生物学の先にあるもの」 2019/10/01

  19. Hv1/VSOP voltage-gated proton channel inhibits migration in response to fMLF in neutrophils

    Yoshifumi Okochi, Yasushi Okamura

    9th Federation of the Asian and Oceanian Physiological Societies 2019/03/29

  20. Measurement of membrane potential change in phagosome of phagocytes

    Okochi Y., Tsutsi H., Okamura Y.

    2018/03

  21. Na-Pi transporter の活性制御機構

    水谷 夏希, 大河内 善史, 岡村 康司

    2018/03

  22. Hv1/VSOP inhibits chemotaxis behavior toward fMFP in mouse neutrophils

    Okochi Y., Okamura Y.

    2017/03

  23. 細胞内膜の膜電位を可視化する―貪食細胞の食胞膜電位の測定―

    大河内善史

    第109回近畿生理談話会 2016/11

  24. 【感染症を見る】最小イオンチャネルHv1/VSOPによる貪食細胞の活性酸素産生の多重制御

    岡村 康司, 大河内 善史, 荒谷 康昭, Adissu Hibert A., 鈴木 和男

    バイオイメージング 2016/06

  25. Voltage-gated proton channel inhibits granule exocytosis and inflammation

    Yoshifumi Okochi

    8th FAOPS international meeting 2015/11

  26. 感染症を見る 最小イオンチャネルHv1/VSOPによる貪食細胞の活性酸素産生の多重制御

    岡村 康司, 大河内 善史, 荒谷 康昭, Adissu Hibret A., 鈴木 和男

    バイオイメージング 2015/09

  27. Multistep regulation of ROS production by voltage-gated proton channel Hv1/VSOP in neutrophils

    yoshifumi okochi

    2015/03

  28. 貪食細胞における電位依存性プロトンチャネルの役割

    大河内善史

    第20回MPO研究会 2014/11

  29. 電位依存性プロトンチャネルVSOPは好中球の走化性を制御する

    大河内善史

    第107回近畿生理談話会 2014/10

  30. Analysis of the role of voltage-gated proton channel Hv1/VSOP in neutrophil chemotaxis

    Yoshifumi Okochi

    2014/03

  31. 電位依存性プロトンチャネルHv1/VSOPは好中球の顆粒放出と炎症を抑制する

    大河内善史

    第19回MPO研究会 2013/10

  32. 膜電位の生理学:貪食細胞における膜電位の役割

    大河内善史

    甲南大学生物学シンポジウム「最新の分子生理学がひもとく生命の原理」 2012/01

  33. 貪食細胞における電位依存性プロトンチャネルVSOPによる活性酸素産生制御の解析

    大河内善史

    第88回日本生理学会大会 2011/03

  34. 貪食細胞における電位依存性プロトンチャネルの役割

    大河内善史

    生理学研究所研究会 貪食細胞機能のイメージング 2010/01

  35. Biochemical characterization of voltage-gated proton channel, VSOP, in phagocytes

    Yoshifumi Okochi

    42nd Annual Scientific Meeting of the European Society for Clinical Investigation 2008/03

  36. DAG-TTX-4/nPKC signaling regulates sensory transduction

    Okochi Y., Ohta A., Kimura K., Mori I.

    14th International C. elegans Meeting 2003/07/02

  37. Analysis of TTX-4 novel protein kinase C-epsilon involved in thermotaxis in C. elegans

    Okochi Y., Kimura K., Okumura M., Mori I.

    13th International C. elegans Meetin 2001/06/24

  38. Isolation of thermotaxis-defective mutants that interact with daf mutations of TGFβ-like signaling pathway in C. elegans

    OKOCHI Yoshifumi, OKUMURA Masatoshi, MORI Ikue

    日本分子生物学会年会プログラム・講演要旨集 1998/12/01

  39. 新旧のタンパクを区別できるマウスを用いたNav1.6のターンオーバの解析~神経細胞の機能が維持される仕組みの解明を目指して~

    山元康平、大河内善史、好岡大輔、阿部学、﨑村建司、岡村康司

    第115回近畿生理学談話会 2023/11/11

  40. 糖鎖修飾から推定する電位依存性プロトンチャネルHv1の2量体化の場所

    大河内善史, 神野有香, 岡村康司

    第 114回近畿生理学談話会

  41. 家族性低リン血症くる病に関するNa+/Pi共輸送体NaPi-IIc/SLC34A3のリン酸輸送機構の解明

    周俊先, 大河内善史, 水谷夏希, 瀬川博子, 岡村康司

    第16回トランスポーター研究会年会

Academic Activities 5

  1. 生理研研究会「イオンチャネルと生体膜のダイナミクス:構造生物学の先にあるもの」

    2020 -

  2. 生理研研究会「イオンチャネルと生体膜のダイナミクス:構造生物学の先にあるもの」

    2019 -

  3. 新学術領域研究「リポクオリティ」の班会議

    2018 -

  4. The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS)

    2018 -

  5. 第120回日本解剖学会総会全国学術集会 第92回日本生理学会大会

    2015 -

Other 1

  1. リサーチフェロー(カナダ、Sergio Grinstein lab)

    2012/06 - 2013/03