ヒト腸管における食品中汚染物質および薬物の安全性評価モデルとしてのドキシサイクリン誘導CYP3A4発現Caco-2細胞株(A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of food contaminants and drugs in the human intestine)

白 霖, 橘 敬祐, 村田 美治佳, 井上 哲利, 水口 裕之, 前田 真一郎, 池村 健治, 奥田 真弘, 日下部 哲也, 近藤 昌夫

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 1-5　2024/01

A Japanese concept of considerations for evaluation of dental materials for tooth bleaching.

Michiko Kurauchi, Yuchi Sato, Hiroyuki Tanishiro, Ryosuke Morita, Masayuki Otsuki, Jun Kaneko, Tomoyuki Tsubaki, Bunsaku Yoshida, Kota Aso, Madoka Murakami, Masuo Kondoh

The Japanese dental science review　Vol. 59　p. 23-27　2023/12　Research paper (scientific journal)

脈管と周囲組織とを結ぶ多彩な生命科学 血管透過性を標的とする重症感染症治療薬の開発

岡田 欣晃, 高山 和雄, 吉岡 靖雄, 近藤 昌夫, 藤尾 慈

日本生化学会大会プログラム・講演要旨集　Vol. 96回　p. [3S09e-02]　2023/10

Claudin-4: A New Molecular Target for Epithelial Cancer Therapy.

Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Shingo Kishi, Masuo Kondoh, Hiroki Kuniyasu

International journal of molecular sciences　Vol. 24　No. 6　2023/03/13　Research paper (scientific journal)

Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning

Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa

Frontiers in Bioscience-Landmark　Vol. 28　No. 1　p. 15-15　2023/01/17　Research paper (scientific journal)

A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection.

Yoshitaka Shirasago, Hidesuke Fukazawa, Shotaro Nagase, Yoshimi Shimizu, Tomoharu Mizukami, Takaji Wakita, Tetsuro Suzuki, Hideki Tani, Masuo Kondoh, Takuya Kuroda, Satoshi Yasuda, Yoji Sato, Kentaro Hanada, Masayoshi Fukasawa

Scientific reports　Vol. 12　No. 1　p. 20243-20243　2022/11/24　Research paper (scientific journal)

A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine.

Lin Bai, Keisuke Tachibana, Michika Murata, Tetsunori Inoue, Hiroyuki Mizuguchi, Shinichiro Maeda, Kenji Ikemura, Masahiro Okuda, Tetsuya Kusakabe, Masuo Kondoh

Toxicology letters　Vol. 370　p. 1-6　2022/11/01　Research paper (scientific journal)

粘膜吸収促進剤の安全性評価の現状と課題

2022/11

Homoharringtonine is a transdermal granular permeation enhancer

Akihiro Watari, Kana Fujiwara, Kiyohito Yagi, Keisuke Tachibana, Takeshi Katsurada, Akira Myoui, Masuo Kondoh

Biochemical and biophysical research communications　Vol. 616　p. 140-144　2022/10　Research paper (scientific journal)

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, Masato Tanaka, Tomoaki Kanbara, Shota Tanaka, Shigeyuki Tamiya, Nagisa Tokunoh, Atsushi Kawai, Masahito Ikawa, Chikako Ono, Keisuke Tachibana, Masuo Kondoh, Masanori Obana, Yoshiharu Matsuura, Akihiro Ohsumi, Takeshi Noda, Takuya Yamamoto, Yasuo Yoshioka, Yu-Suke Torisawa, Hiroshi Date, Yasushi Fujio, Miki Nagao, Kazuo Takayama, Yoshiaki Okada

Science advances　Vol. 8　No. 38　2022/09/23　Research paper (scientific journal)

LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer.

Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Motoki Matsuura, Tadahi Okada, Arisa Kura, Daichi Ishii, Masuo Kondoh, Tsuyoshi Saito, Takashi Kojima

Tissue barriers　p. 2106113-2106113　2022/07/26　Research paper (scientific journal)

Safety evaluation of MA-T after ingestion in mice.

Takahiro Noguchi, Keisuke Tachibana, Tsuyoshi Inoue, Takayoshi Sakai, Kazutake Tsujikawa, Yasushi Fujio, Yoshiaki Yamagishi, Shigeto Hamaguchi, Satoshi Kutsuna, Masuo Kondoh

Toxicology　Vol. 477　p. 153254-153254　2022/07/07　Research paper (scientific journal)

Hypomethylation of CLDN4 Gene Promoter Is Associated with Malignant Phenotype in Urinary Bladder Cancer.

Fumisato Maesaka, Masaomi Kuwada, Shohei Horii, Shingo Kishi, Rina Fujiwara-Tani, Shiori Mori, Kiyomu Fujii, Takuya Mori, Hitoshi Ohmori, Takuya Owari, Makito Miyake, Yasushi Nakai, Nobumichi Tanaka, Ujjal Kumar Bhawal, Yi Luo, Masuo Kondoh, Kiyohide Fujimoto, Hiroki Kuniyasu

International journal of molecular sciences　Vol. 23　No. 12　2022/06/10　Research paper (scientific journal)

カニクイザルを用いたClaudin-5指向性血液脳関門制御技術の有効性及び安全性評価

西野 樹, 橘 敬祐, 橋本 洋祐, 岩下 有美, 白倉 圭祐, 岡田 欣晃, 竹田 浩之, 國安 弘基, 近藤 昌夫

日本DDS学会学術集会プログラム予稿集　Vol. 38回　p. 98-98　2022/06

Modifying the blood-brain barrier by targeting claudin-5: Safety and risks.

Erika Wakayama, Taiki Kuzu, Keisuke Tachibana, Ryuichi Hirayama, Yoshiaki Okada, Masuo Kondoh

Annals of the New York Academy of Sciences　2022/05/04　Research paper (scientific journal)

剖検例おける肺血管内皮Claudin-5発現の意義

谷 里奈, 近藤 昌夫, 國安 弘基

日本病理学会会誌　Vol. 111　No. 1　p. 321-321　2022/03

先端DDS技術のレギュラトリーサイエンス研究 非ヒト霊長類を用いたClaudin-5指向性血液脳関門制御技術の有効性及び安全性評価

西野 樹, 橘 敬祐, 橋本 洋祐, 岩下 有美, 白倉 圭祐, 岡田 欣晃, 竹田 浩之, 國安 弘基, 近藤 昌夫

日本薬学会年会要旨集　Vol. 142年会　p. 26G-pm03S　2022/03

Claudinopathyの基盤研究 Clauidin-5と肺疾患

若山 英里香, 橘 敬祐, 橋本 洋祐, 平山 龍一, 谷 里奈, 國安 弘基, 竹田 浩之, 岡田 欣晃, 藤尾 慈, 近藤 昌夫

日本薬学会年会要旨集　Vol. 142年会　p. 28PO2-02S　2022/03

腸内細菌による薬物代謝を考慮したレギュレーションの現状とRWD解析

庄 真喜子, 太田 翔平, 山根 章寛, 橘 敬祐, 池村 健治, 前田 真一郎, 奥田 真弘, 原田 和夫, 藤尾 慈, 國澤 純, 近藤 昌夫

日本薬学会年会要旨集　Vol. 142年会　p. 27L-pm07S　2022/03

Translocation of LSR from tricellular corners causes macropinocytosis at cell–cell interface as a trigger for breaking out of contact inhibition

Takayuki Kohno, Takumi Konno, Shin Kikuchi, Masuo Kondoh, Takashi Kojima

The FASEB Journal　Vol. 35　No. 9　2021/09　Research paper (scientific journal)

Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells

Kizuku Ohwada, Takumi Konno, Takayuki Kohno, Masaya Nakano, Tsuyoshi Ohkuni, Ryo Miyata, Takuya Kakuki, Masuo Kondoh, Kenichi Takano, Takashi Kojima

International Journal of Molecular Sciences　Vol. 22　No. 16　p. 8390-8390　2021/08/04　Research paper (scientific journal)

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, Masuo Kondoh

Journal of controlled release : official journal of the Controlled Release Society　Vol. 336　p. 105-111　2021/06/09　Research paper (scientific journal)

Overview of the Premarketing and Postmarketing Requirements for Drugs Granted Japanese Conditional Marketing Approval.

Shunsuke Matsushita, Keisuke Tachibana, Tetsuya Kusakabe, Ryuichi Hirayama, Yasuo Tsutsumi, Masuo Kondoh

Clinical and translational science　Vol. 14　No. 3　p. 806-811　2021/05　Research paper (scientific journal)

Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood-brain barrier.

Mariana Castro Dias, Adolfo Odriozola Quesada, Sasha Soldati, Fabio Bösch, Isabelle Gruber, Tobias Hildbrand, Derya Sönmez, Tejas Khire, Guillaume Witz, James L McGrath, Jörg Piontek, Masuo Kondoh, Urban Deutsch, Benoît Zuber, Britta Engelhardt

Journal of cell science　Vol. 134　No. 8　2021/04/15　Research paper (scientific journal)

Legislation on the Roles of the Pharmacist and Pharmacy in the Revision of the Pharmaceutical and Medical Device Act and the Pharmacists Act in Japan.

Kento Takamura, Keisuke Tachibana, Tetsunari Kihira, Kiyohito Nakai, Yasuo Tsutsumi, Masuo Kondoh

Therapeutic innovation & regulatory science　Vol. 55　No. 2　p. 304-308　2021/03　Research paper (scientific journal)

Antiviral Effects of the Anti-Occludin Monoclonal Antibody on Persistent Hepatitis C Virus Infection in a Human Liver Chimeric Mouse Model

Yoshimi Shimizu, Takeru Suzuki, Yoshitaka Shirasago, Masuo Kondoh, Tetsuro Suzuki, Takaji Wakita, Masayoshi Fukasawa

BPB Reports　Vol. 4　No. 5　p. 142-147　2021　Research paper (scientific journal)

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier.

Yosuke Hashimoto, Matthew Campbell, Keisuke Tachibana, Yoshiaki Okada, Masuo Kondoh

Biological & pharmaceutical bulletin　Vol. 44　No. 10　p. 1380-1390　2021　Research paper (scientific journal)

Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection.

Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, Mikako Shirouzu, Masayoshi Fukasawa

FEBS letters　Vol. 595　No. 2　p. 220-229　2021/01　Research paper (scientific journal)

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review.

Keisuke Tachibana, Yumi Iwashita, Erika Wakayama, Itsuki Nishino, Taiki Nishikaji, Masuo Kondoh

Pharmaceutics　Vol. 12　No. 12　2020/12/19　Research paper (scientific journal)

Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.

Julia Baguña Torres, Michael Mosley, Sofia Koustoulidou, Samantha Hopkins, Stefan Knapp, Apirat Chaikuad, Masuo Kondoh, Keisuke Tachibana, Veerle Kersemans, Bart Cornelissen

Journal of nuclear medicine : official publication, Society of Nuclear Medicine　Vol. 61　No. 12　p. 1756-1763　2020/12　Research paper (scientific journal)

Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model.

Yoshimi Shimizu, Katsuhiro Isoda, Yuichiro Taira, Ikuko Taira, Masuo Kondoh, Isao Ishida

European journal of pharmacology　Vol. 887　p. 173596-173596　2020/11/15　Research paper (scientific journal)

Role of Nuclear Claudin-4 in Renal Cell Carcinoma.

Takuya Owari, Takamitsu Sasaki, Kiyomu Fujii, Rina Fujiwara-Tani, Shingo Kishi, Shiori Mori, Takuya Mori, Kei Goto, Isao Kawahara, Yasushi Nakai, Makito Miyake, Yi Luo, Nobumichi Tanaka, Masuo Kondoh, Kiyohide Fujimoto, Hiroki Kuniyasu

International journal of molecular sciences　Vol. 21　No. 21　2020/11/06　Research paper (scientific journal)

The Roadmap to Approval under Japan's Two-Track Regulatory System: Comparing Six Regenerative Medical Products.

Shunsuke Matsushita, Keisuke Tachibana, Tetsuya Kusakabe, Ryuichi Hirayama, Yasuo Tsutsumi, Masuo Kondoh

Cell stem cell　Vol. 27　No. 4　p. 515-518　2020/10/01　Research paper (scientific journal)

C型肝炎ウイルス侵入を阻害する抗OCLN低分子抗体の創出

清水 芳実, 篠田 雄大, 白砂 圭崇, 近藤 昌夫, 新屋 直子, 花田 賢太郎, 八木 清仁, 鈴木 哲朗, 脇田 隆字, 染谷 友美, 白水 美香子, 深澤 征義

日本生化学会大会プログラム・講演要旨集　Vol. 93回　p. [P-774]　2020/09

少子高齢化社会を見据えた社会保障のエコシステムにおける病院・薬局薬剤師の役割に関する考察

高村建人, 鈴木信敏, 橘敬祐, 近藤昌夫

レギュラトリーサイエンス学会誌　Vol. 10　No. 3　2020/09

市販後に性能が変わりうる医療機器のレギュラトリーサイエンス

太田和, 橘敬祐, 日下部哲也, 近藤昌夫

レギュラトリーサイエンス学会誌　Vol. 10　No. 3　2020/09

A Concept for a Japanese Regulatory Framework for Emerging Medical Devices with Frequently Modified Behavior.

Nagomi Ota, Keisuke Tachibana, Tetsuya Kusakabe, Shoji Sanada, Masuo Kondoh

Clinical and translational science　Vol. 13　No. 5　p. 877-879　2020/09　Research paper (scientific journal)

A Method to Prepare a Bioprobe for Regulatory Science of the Drug Delivery System to the Brain: An Angulin Binder to Modulate Tricellular Tight Junction-Seal.

Keisuke Tachibana, Masuo Kondoh

Methods in molecular biology (Clifton, N.J.)　2020/08/14　Research paper (scientific journal)

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma.

Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Yi Luo, Takuya Mori, Shingo Kishi, Shiori Mori, Sayako Matsushima-Otsuka, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Masuo Kondoh, Masayuki Sho, Hiroki Kuniyasu

Oncotarget　Vol. 11　No. 31　p. 2982-2994　2020/08　Research paper (scientific journal)

Tight junction modulators for drug delivery to the central nervous system.

Yosuke Hashimoto, Keisuke Tachibana, Masuo Kondoh

Drug discovery today　Vol. 25　No. 8　p. 1477-1486　2020/08　Research paper (scientific journal)

New Japanese Regulatory Frameworks for Post-Marketing Management of Pharmaceutical Products.

Kento Takamura, Keisuke Tachibana, Tetsuya Kusakabe, Kiyohito Nakai, Yasuo Tsutsumi, Masuo Kondoh

Pharmaceutical research　Vol. 37　No. 7　p. 122-122　2020/06/08　Research paper (scientific journal)

Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.

Rina Fujiwara-Tani, Kiyomu Fujii, Shiori Mori, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Chie Nakashima, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori, Masayuki Sho, Masuo Kondoh, Yi Luo, Hiroki Kuniyasu

International journal of molecular sciences　Vol. 21　No. 11　2020/05/28　Research paper (scientific journal)

Targeting claudin-4 enhances chemosensitivity in breast cancer.

Yi Luo, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara-Tani, Shiori Mori, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Isao Kawahara, Masuo Kondoh, Hiroki Kuniyasu

Cancer science　Vol. 111　No. 5　p. 1840-1850　2020/05　Research paper (scientific journal)

Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1.

Takumi Konno, Takayuki Kohno, Shin Kikuchi, Hiroshi Shimada, Seiro Satohisa, Tsuyoshi Saito, Masuo Kondoh, Takashi Kojima

Tissue barriers　Vol. 8　No. 1　p. 1695475-1695475　2020/04　Research paper (scientific journal)

Therapeutic innovation and regulatory sciences for paracellular absorption enhancers for biologics

Keisuke Tachibana, Masuo Kondoh

Drug Delivery System　Vol. 35　No. 1　p. 20-26　2020　Research paper (scientific journal)

Clostridium perfringens enterotoxin activates YAP in oral squamous cell carcinomas

中嶋千惠, 中嶋千惠, 山本一彦, 岸真五, 佐々木隆光, 大森斉, 谷里奈, 森汐莉, 藤井澄, 西口由希子, 西口由希子, 近藤昌夫, 桐田忠昭, 國安弘基

日本癌学会学術総会抄録集(Web)　Vol. 79th　No. 4　p. 309-321　2020

A Method to Prepare Claudin-Modulating Recombinant Proteins.

Keisuke Tachibana, Masuo Kondoh

Methods in molecular biology (Clifton, N.J.)　Vol. 2109　p. 251-260　2020　Research paper (scientific journal)

Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.

Takuro Kyuno, Daisuke Kyuno, Takayuki Kohno, Takumi Konno, Shin Kikuchi, Chihiro Arimoto, Hiroshi Yamaguchi, Masafumi Imamura, Yasutoshi Kimura, Masuo Kondoh, Ichiro Takemasa, Takashi Kojima

Histochemistry and cell biology　Vol. 153　No. 1　p. 5-16　2020/01　Research paper (scientific journal)

Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.

Takamitsu Sasaki, Rina Fujiwara-Tani, Shingo Kishi, Shiori Mori, Yi Luo, Hitoshi Ohmori, Isao Kawahara, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Masayuki Sho, Masuo Kondo, Hiroki Kuniyasu

Cancer medicine　Vol. 8　No. 15　p. 6700-6708　2019/11　Research paper (scientific journal)

Interpenetration of innovation and regulation for drug development

Kondoh, M

Vol. 34　No. 5　2019/11

Development of drug delivery system for treatment of central nervous system diseases targeting tight junctions

橋本洋佑, 近藤昌夫, 竹田浩之

Drug Delivery System　Vol. 34　No. 5　p. 374-384　2019/11

Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin

Yoshimi Shimizu, Yoshitaka Shirasago, Takeru Suzuki, Tomoyuki Hata, Masuo Kondoh, Kentaro Hanada, Kiyohito Yagi, Masayoshi Fukasawa

JOURNAL OF BIOCHEMISTRY　Vol. 166　No. 4　p. 297-308　2019/10　Research paper (scientific journal)

A Review of the Regulatory Framework for Initiation and Acceleration of Patient Access to Innovative Medical Products in Japan.

Shunsuke Matsushita, Keisuke Tachibana, Kiyohito Nakai, Shoji Sanada, Masuo Kondoh

Clinical pharmacology and therapeutics　Vol. 106　No. 3　p. 508-511　2019/09　Research paper (scientific journal)

Development of drug delivery system based on biology of epithelial barrier.

Kondoh, M

Drug Delivery System　Vol. 34　p. 279-283　2019/09

Development of drug delivery system based on biology of epithelial barrier

Vol. 34　No. 4　2019/09

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1.

Yosuke Hashimoto, Keisuke Tachibana, Susanne M Krug, Jun Kunisawa, Michael Fromm, Masuo Kondoh

International journal of molecular sciences　Vol. 20　No. 16　2019/08/17　Research paper (scientific journal)

本邦の上皮バリアの生物学に育まれた創薬を目指して

近藤昌夫, 竹田浩之

実験医学　Vol. 37　p. 1793-1796　2019/07

Human-rat chimeric anti-occludin monoclonal antibodies inhibit hepatitis C virus infection

Yoshimi Shimizu, Kohei Yoneda, Yoshitaka Shirasago, Takeru Suzuki, Minoru Tada, Akiko Ishii-Watabe, Kazuo Sugiyama, Tetsuro Suzuki, Takaji Wakita, Kiyohito Yagi, Masuo Kondoh, Masayoshi Fukasawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 514　No. 3　p. 785-790　2019/06　Research paper (scientific journal)

上皮を標的とした創薬イノベーションとレギュラトリーサイエンス

橘敬祐, 近藤昌夫

ファルマシア　Vol. 55　No. 6　p. 522-526　2019/06

C型肝炎ウイルス感染阻害活性を有するoccludin抗体のdruggability向上に向けた検討

鈴木 建, 清水 芳実, 白砂 圭崇, 米田 宏平, 多田 稔, 石井 明子, 花田 賢太郎, 八木 清仁, 近藤 昌夫, 深澤 征義

日本薬学会年会要旨集　Vol. 139年会　No. 3　p. 148-148　2019/03

非アルコール性脂肪肝炎(NASH)形成期におけるビタミンE修飾ヘテロ核酸製剤の経腸デリバリーの効果

小林 裕之介, 渡辺 知恵, Yi Cheng, 松本 昭博, 渡利 彰浩, 近藤 昌夫, 小比賀 聡, 横田 隆徳, 村上 正裕

日本薬学会年会要旨集　Vol. 139年会　No. 4　p. 91-91　2019/03

Development of a bivalent food poisoning vaccine: augmented antigenicity of the C-terminus of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2.

Hosomi K, Hinenoya A, Suzuki H, Nagatake T, Nishino T, Tojima Y, Hirata SI, Matsunaga A, Kondoh M, Yamasaki S, Kunisawa J

International immunology　Vol. 31　No. 2　p. 91-100　2019/02　Research paper (scientific journal)

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs.

Yosuke Hashimoto, Yoshiaki Okada, Keisuke Shirakura, Keisuke Tachibana, Makoto Sawada, Kiyohito Yagi, Takefumi Doi, Masuo Kondoh

The Journal of pharmacology and experimental therapeutics　Vol. 368　No. 2　p. 179-186　2019/02　Research paper (scientific journal)

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

Keisuke Shirakura, Ryosuke Ishiba, Taito Kashio, Risa Funatsu, Toru Tanaka, So-Ichiro Fukada, Kenji Ishimoto, Nobumasa Hino, Masuo Kondoh, Yukio Ago, Yasushi Fujio, Kiichiro Yano, Takefumi Doi, William C Aird, Yoshiaki Okada

Journal of cell science　Vol. 132　No. 1　2019/01　Research paper (scientific journal)

The Clinical Innovation Network: a policy for promoting development of drugs and medical devices in Japan.

Shunsuke Matsushita, Keisuke Tachibana, Masuo Kondoh

Drug discovery today　Vol. 24　No. 1　p. 4-8　2019/01　Research paper (scientific journal)

Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.

Rina Fujiwara-Tani, Takamitsu Sasaki, Yi Luo, Kei Goto, Isao Kawahara, Yukiko Nishiguchi, Shingo Kishi, Shiori Mori, Hitoshi Ohmori, Masuo Kondoh, Hiroki Kuniyasu

Oncotarget　Vol. 9　No. 100　p. 37367-37378　2018/12/21　Research paper (scientific journal)

Development of adjuvant-free bivalent food poisoning vaccine by augmenting the antigenicity of Clostridium perfringens enterotoxin.

Suzuki, H, Hosomi, K, Nasu, A, Kondoh, M, Kunisawa, J

Front Immunol　Vol. 9　2018/10　Research paper (scientific journal)

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

Yosuke Hashimoto, Wei Zhou, Kohtaroh Hamauchi, Keisuke Shirakura, Takefumi Doi, Kiyohito Yagi, Tatsuya Sawasaki, Yoshiaki Okada, Masuo Kondoh, Hiroyuki Takeda

Scientific reports　Vol. 8　No. 1　p. 8383-8383　2018/05/30　Research paper (scientific journal)

Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.

Yosuke Hashimoto, Tomoyuki Hata, Minoru Tada, Manami Iida, Akihiro Watari, Yoshiaki Okada, Takefumi Doi, Hiroki Kuniyasu, Kiyohito Yagi, Masuo Kondoh

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences　Vol. 117　p. 161-167　2018/05/30　Research paper (scientific journal)

Angubindin-1 opens the blood–brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

Satoshi Zeniya, Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota

Journal of Controlled Release　Vol. 283　p. 126-134　2018/05　Research paper (scientific journal)

Monoclonal Antibodies against Occludin Completely Prevented Hepatitis C Virus Infection in a Mouse Model.

Yoshimi Shimizu, Yoshitaka Shirasago, Masuo Kondoh, Tetsuro Suzuki, Takaji Wakita, Kentaro Hanada, Kiyohito Yagi, Masayoshi Fukasawa

Journal of virology　Vol. 92　No. 8　2018/04/15　Research paper (scientific journal)

Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells.

Koji Matsuhisa, Akihiro Watari, Kazuki Iwamoto, Masuo Kondoh, Kiyohito Yagi

Journal of natural medicines　Vol. 72　No. 2　p. 448-455　2018/03　Research paper (scientific journal)

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.

Hidehiko Suzuki, Takahiro Nagatake, Ayaka Nasu, Huangwenxian Lan, Koji Ikegami, Mitsutoshi Setou, Yoko Hamazaki, Hiroshi Kiyono, Kiyohito Yagi, Masuo Kondoh, Jun Kunisawa

Scientific reports　Vol. 8　No. 1　p. 2904-2904　2018/02/13　Research paper (scientific journal)

Dodecylmaltoside Modulates Bicellular Tight Junction Contacts to Promote Enhanced Permeability

K. Gradauer, M. Iida, A. Watari, M. Kataoka, S. Yamashita, M. Kondoh, S. T. Buckley

Molecular Pharmaceutics　Vol. 14　No. 12　p. 4734-4740　2017/12/04　Research paper (scientific journal)

抗C型肝炎ウイルス活性を有する抗Occludinモノクローナル抗体の性状解析と改変

深澤 征義, 清水 芳実, 米田 宏平, 白砂 圭崇, 鈴木 哲朗, 脇田 隆字, 花田 賢太郎, 八木 清仁, 近藤 昌夫

生命科学系学会合同年次大会　Vol. 2017年度　p. [3LBA-113]　2017/12

Creation of a Claudin-2 Binder and Its Tight Junction-Modulating Activity in a Human Intestinal Model.

Mutsumi Takigawa, Manami Iida, Shotaro Nagase, Hidehiko Suzuki, Akihiro Watari, Minoru Tada, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Kiyohito Yagi, Jun Kunisawa, Masuo Kondoh

The Journal of pharmacology and experimental therapeutics　Vol. 363　No. 3　p. 444-451　2017/12　Research paper (scientific journal)

Homoharringtonine enhances transdermal absorption in the skin by regulating epidermal tight junction barriers.

iyohito Yagi, Akihiro Watari, Kana Fujiwara, Nobutoshi Suzuki, Masuo Kondoh

2017/12　Research paper (international conference proceedings)

Use of a Time-Resolved Fluorescence Resonance Energy Transfer-based screening assay to identify a claudin-4 binder that attenuates tight junction barrier function.

Akihiro Watari, Kiyohito Yagi, Masuo Kondoh

2017/12　Research paper (international conference proceedings)

Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay.

Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh

Scientific reports　Vol. 7　No. 1　p. 14514-14514　2017/11/06　Research paper (scientific journal)

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.

Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi, Masuo Kondoh

The Journal of pharmacology and experimental therapeutics　Vol. 363　No. 2　p. 275-283　2017/11　Research paper (scientific journal)

Development of a Quenchbody for the Detection and Imaging of the Cancer-Related Tight-Junction-Associated Membrane Protein Claudin.

Hee-Jin Jeong, Takuya Kawamura, Manami Iida, Yumi Kawahigashi, Mutsumi Takigawa, Yuki Ohmuro-Matsuyama, Chan-I Chung, Jinhua Dong, Masuo Kondoh, Hiroshi Ueda

Analytical chemistry　Vol. 89　No. 20　p. 10783-10789　2017/10/17　Research paper (scientific journal)

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.

Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M

Journal of controlled release : official journal of the Controlled Release Society　Vol. 260　p. 1-11　2017/08　Research paper (scientific journal)

インタクトなOccludinの細胞外領域を認識するモノクローナル抗体の樹立と性状解析

白砂 圭崇, 清水 芳実, 近藤 昌夫, 八木 清仁, 鈴木 哲朗, 脇田 隆字, 花田 賢太郎, 深澤 征義

日本細胞生物学会大会講演要旨集　Vol. 69回　p. 129-129　2017/05

Rebeccamycin attenuates TNF-α-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production

Akihiro Watari, Sakamoto Yuta, Hisaie Kota, Kazuki Iwamoto, Miho Fueta, Kiyohito Yagi, Masuo Kondoh

Cellular Physiology and Biochemistry　Vol. 41　No. 5　p. 1924-1934　2017/04　Research paper (scientific journal)

Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer

Hashimoto, Y. Fukasawa, M. Kuniyasu, H. Yagi, K. Kondoh

Ann N Y Acad Sci　Vol. 1397　No. 1　p. 5-16　2017/04　Research paper (scientific journal)

Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure.

Imai S, Morishita Y, Hata T, Kondoh M, Yagi K, Gao JQ, Nagano K, Higashisaka K, Yoshioka Y, Tsutsumi Y

Biochemical and Biophysical Research Communications　Vol. 484　No. 3　p. 543-549　2017/03　Research paper (scientific journal)

Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers

Yosuke Hashimoto, Kiyohito Yagi, Masuo Kondoh

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 469　No. 1　p. 45-53　2017/01　Research paper (scientific journal)

Claudin-binder C-CPE mutants enhance permeability of insulin across human nasal epithelial cells

Takashi Kojima, Masuo Kondoh, Takashi Keira, Ken-ichi Takano, Takuya Kakuki, Yakuto Kaneko, Ryo Miyata, Kazuaki Nomura, Kazufumi Obata, Takayuki Kohno, Takumi Konno, Norimasa Sawada, Tetsuo Himi

DRUG DELIVERY　Vol. 23　No. 8　p. 2703-2710　2016/10　Research paper (scientific journal)

Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody.

Yosuke Hashimoto, Yumi Kawahigashi, Tomoyuki Hata, Xiangru Li, Akihiro Watari, Minoru Tada, Akiko Ishii-Watabe, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Hiroki Kuniyasu, Kiyohito Yagi, Masuo Kondoh

Pharmacology research & perspectives　Vol. 4　No. 5　2016/10　Research paper (scientific journal)

Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model

Yosuke Hashimoto, Minoru Tada, Manami Iida, Shotaro Nagase, Tomoyuki Hata, Akihiro Watari, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Kiyohito Yagi, Masuo Kondoh

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 477　No. 1　p. 91-95　2016/08　Research paper (scientific journal)

抗Claudin-1抗体にを用いたClaudin-1の細胞内動態の解析

白砂 圭崇, 清水 芳実, 花田 賢太郎, 近藤 昌夫, 八木 清仁, 深澤 征義

日本細胞生物学会大会講演要旨集　Vol. 68回　p. 91-91　2016/05

Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection

Yoshitaka Shirasago, Yoshimi Shimizu, Isei Tanida, Tetsuro Suzuki, Ryosuke Suzuki, Kazuo Sugiyama, Takaji Wakita, Kentaro Hanada, Kiyohito Yagi, Masuo Kondoh, Masayoshi Fukasawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 39　No. 5　p. 839-848　2016/05　Research paper (scientific journal)

上皮細胞を標的とした創薬基盤研究 抗Occludin抗体の作製と性状解析

清水 芳実, 白砂 圭崇, 米田 宏平, 近藤 昌夫, 八木 清仁, 花田 賢太郎, 深澤 征義

日本薬学会年会要旨集　Vol. 136年会　No. 3　p. 134-134　2016/03

Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression

Akihiro Watari, Maki Hasegawa, Kiyohito Yagi, Masuo Kondoh

PLOS ONE　Vol. 11　No. 1　2016/01　Research paper (scientific journal)

Occludin細胞外ドメインに対するモノクローナル抗体の樹立と本抗体によるC型肝炎ウイルス感染阻害

深澤 征義, 清水 芳実, 白砂 圭崇, 近藤 昌夫, 八木 清仁, 鈴木 哲朗, 脇田 隆字, 花田 賢太郎

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [1P1144]-[1P1144]　2015/12

Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer.

Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu

Cancer letters　Vol. 369　No. 1　p. 212-21　2015/12/01　Research paper (scientific journal)

Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.

Tsuyoshi Kono, Masuo Kondoh, Daisuke Kyuno, Tatsuya Ito, Yasutoshi Kimura, Masafumi Imamura, Takayuki Kohno, Takumi Konno, Tomohisa Furuhata, Norimasa Sawada, Koichi Hirata, Takashi Kojima

Pharmacology research & perspectives　Vol. 3　No. 6　2015/12　Research paper (scientific journal)

Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model

Misaki Nakajima, Shotaro Nagase, Manami Iida, Shuji Takeda, Mayo Yamashita, Akihiro Watari, Yoshitaka Shirasago, Masayoshi Fukasawa, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyohito Yagi, Masuo Kondoh

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 354　No. 3　p. 440-447　2015/09　Research paper (scientific journal)

Tricellular tight junction binder、angubindin-1、の創製とバリア制御活性解析

井口 大輔, 早石 知浩, Krug Susanne M., 竹田 浩之, Fromm Michael, 渡利 彰浩, 澤崎 達也, 八木 清仁, 近藤 昌夫

日本DDS学会学術集会プログラム予稿集　Vol. 31回　p. 153-153　2015/06

Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression

Akihiro Watari, Maki Hashegawa, Thanchanok Muangman, Kiyohito Yagi, Masuo Kondoh

BIOTECHNOLOGY LETTERS　Vol. 37　No. 6　p. 1177-1185　2015/06　Research paper (scientific journal)

Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model.

Masayoshi Fukasawa, Shotaro Nagase, Yoshitaka Shirasago, Manami Iida, Mayo Yamashita, Kohki Endo, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Kentaro Hanada, Hiroki Kuniyasu, Masuo Kondoh

Journal of virology　Vol. 89　No. 9　p. 4866-79　2015/05　Research paper (scientific journal)

C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine

Hidehiko Suzuki, Akihiro Watari, Eri Hashimoto, Miki Yonemitsu, Hiroshi Kiyono, Kiyohito Yagi, Masuo Kondoh, Jun Kunisawa

PLOS ONE　Vol. 10　No. 5　2015/05　Research paper (scientific journal)

Discovery of Anti-Claudin-1 Antibodies as Candidate Therapeutics against Hepatitis C Virus

Mayo Yamashita, Manami Iida, Minoru Tada, Yoshitaka Shirasago, Masayoshi Fukasawa, Shotaro Nagase, Akihiro Watari, Akiko Ishii-Watabe, Kiyohito Yagi, Masuo Kondoh

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 353　No. 1　p. 112-118　2015/04　Research paper (scientific journal)

Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin

Koji Matsuhisa, Seiji Yamane, Toru Okamoto, Akihiro Watari, Masuo Kondoh, Yoshiharu Matsuura, Kiyohito Yagi

Biochem. Biophys. Res. Commun.　Vol. 462　No. 1　p. 52-57　2015/04　Research paper (scientific journal)

Occludinのノックアウト肝細胞の樹立と本細胞を用いたHCV感染の解析

白砂 圭崇, 谷田 以誠, 清水 芳実, 鈴木 哲朗, 脇田 隆字, 花田 賢太郎, 近藤 昌夫, 安部 良, 深澤 征義

日本薬学会年会要旨集　Vol. 135年会　No. 3　p. 74-74　2015/03

Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers

Akihiro Watari, Maki Hashegawa, Kiyohito Yagi, Masuo Kondoh

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS　Vol. 89　p. 232-238　2015/01　Research paper (scientific journal)

Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy

Isoda Katsuhiro, Kondoh Masuo, Yoshioka Yasuo, Tsutsumi Yasuo, Imazawa Takayoshi, Nishimura Tetsuji, Ishida Isao, Yagi Kiyohito

Fundamental Toxicological Sciences　Vol. 2　No. 1　p. 19-23　2015/01　Research paper (scientific journal)

Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy.

Xiangru Li, Manami Iida, Minoru Tada, Akihiro Watari, Yumi Kawahigashi, Yuka Kimura, Taku Yamashita, Akiko Ishii-Watabe, Tadayuki Uno, Masayoshi Fukasawa, Hiroki Kuniyasu, Kiyohito Yagi, Masuo Kondoh

The Journal of pharmacology and experimental therapeutics　Vol. 351　No. 1　p. 206-13　2014/10　Research paper (scientific journal)

Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells

Pil Soo Sung, Asako Murayama, Wonseok Kang, Myung-Sun Kim, Seung Kew Yoon, Masayoshi Fukasawa, Masuo Kondoh, Jin-Soo Kim, Hyongbum Kim, Takanobu Kato, Eui-Cheol Shin

JOURNAL OF VIROLOGY　Vol. 88　No. 16　p. 9233-9244　2014/08　Research paper (scientific journal)

Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter.

Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T

Arterioscler Thromb Vasc Biol.　Vol. 34　No. 7　p. 1531-1538　2014/07　Research paper (scientific journal)

Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin

Xiangru LI, Rie SAEKI, Akihiro WATARI, Kiyohito YAGI, Masuo KONDOH

Eur. J. Pharm. Sci.　Vol. 52　p. 132-137　2014/02　Research paper (scientific journal)

A baculoviral display system to assay viral entry

Yoshida, Akihiro Watari, Kiyohito Yagi, Takao Hamakubo, Masuo Kondoh M

Biol. Pharm. Bull.　Vol. 36　No. 11　p. 1867-1869　2013/11　Research paper (scientific journal)

Acute and chronic nephrotoxicity of platinum nanoparticles in mice

Yoshiaki Yamagishi, Akihiro Watari, Yuya Hayata, X. Li, Yasuo Yoshioka, Masuo Kondoh, Yasuo Tsutsumi, Kiyohito Yagi, K

Nanoscale Res. Lett.　Vol. 8　2013/09　Research paper (scientific journal)

Development of an adenovirus vector containing a hepatitis C virus expression cassette and its application

Takeshi YOSHIDA, Masuo KONDOH, Hiroyuki MIZUGUCHI, Kiyohito YAGI

Yakugaku Zasshi　Vol. 133　No. 3　p. 305-311　2013/03

Hepatotoxicity of sub-nanosized platinum particles in mice

Yoshiaki YAMAGISHI, Akihiro WATARI, Yuya HAYATA, Xiangru LI, Masuo KONDOH, Yasuo TSUTSUMI, Kiyohito YAGI

Pharmazie　Vol. 68　No. 3　p. 178-182　2013/03　Research paper (scientific journal)

Recent Advances in Claudin-Targeting Technology

Nagase Shotaro, Doyama Ryo, Yagi Kiyohito, Kondoh Masuo

Biological and Pharmaceutical Bulletin　Vol. 36　No. 5　p. 708-714　2013

Percolation Analysis in Electrical Conductivity of Madin-Darby Canine Kidney and Caco-2 Cells by Permeation-Enhancing Agents

Washiyama Makiko, Koizumi Naoya, Fujii Makiko, Kondoh Masuo, Yagi Kiyohito, Watanabe Yoshiteru

Biological and Pharmaceutical Bulletin　Vol. 36　No. 3　p. 384-389　2013

A simple reporter assay for screening claudin-4 modulators

Akihiro WATARI, Kiyohito YAGI, Masuo KONDOH

Biochem. Biophys. Res. Commun.　Vol. 426　No. 4　p. 454-460　2012/09　Research paper (scientific journal)

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a

Fuminori Sakurai, Norihisa Furukawa, Maiko Higuchi, Sayuri Okamoto, Kaori Ono, Takeshi Yoshida, Masuo Kondoh, Kiyohito Yagi, Naoya Sakamoto, Kazufumi Katayama, Hiroyuki Mizuguchi

VIRUS RESEARCH　Vol. 165　No. 2　p. 214-218　2012/05　Research paper (scientific journal)

Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder

Koji MATSUHISA, Masuo KONDOH, Hidehiko SUZUKI, Kiyohito YAGI

Biochem Biophys Res Commun.　Vol. 423　No. 2　p. 229-233　2012/05　Research paper (scientific journal)

Creation and biochemical analysis of a broad-specific claudin binder

Azusa Takahashi, Yumiko Saito, Masuo Kondoh, Kyohei Matsushita, Susanne M. Krug, Hidehiko Suzuki, Hirofumi Tsujino, Xiangru Li, Hiroshi Aoyama, Koji Matsuhisa, Tadayuki Uno, Michael Fromm, Takao Hamakubo, Kiyohito Yagi

Biomaterials　Vol. 33　No. 12　p. 3464-3474　2012/04　Research paper (scientific journal)

Proof of concept for claudin-targeted drug development

Hidehiko Suzuki, Masuo Kondoh, Azusa Takahashi, Kiyohito Yagi

BARRIERS AND CHANNELS FORMED BY TIGHT JUNCTION PROTEINS II　Vol. 1258　p. 65-70　2012　Research paper (scientific journal)

Oil-in-water emulsion lotion providing controlled release using 2-methacryloyloxyethyl phosphorylcholine n-butyl methacrylate copolymer as emulsifier.

Akiko Ishikawa, Makiko Fujii, Kumi Morimoto, Tomomi Yamada, Naoya Koizumi, Masuo Kondoh, Yoshiteru Watanabe

Results in pharma sciences　Vol. 2　p. 16-22　2012

The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice

Hidehiko SUZUKI, Masuo KONDOH, Hideki KAKUTANI, Hiroshi UCHIDA, Takao HAMAKUBO, Kiyohito YAGI

Biomaterials　Vol. 33　No. 1　p. 317-324　2012/01　Research paper (scientific journal)

Well-dispersed amorphous nanosilicas induce fatal toxicity and consumptive coagulopathy after systemic exposure.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Kondoh M, Yagi K, Mayumi T, Itoh N, Tsunoda S, Tsutsumi Y

Nanotechnol　Vol. 23　No. 4　2011/12　Research paper (scientific journal)

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

Takeshi YOSHIDA, Kazuo TAKAYAMA, Masuo KONDOH, Fuminori SAKURAI, Hideki TANI, Naoya SAKAMOTO, Yoshiharu MATSURA, Hiroyuki MIZUGUCHI, Kiyohito YAGI

Biochem. Biophys. Res. Commun.　Vol. 416　No. 1-2　p. 119-124　2011/12　Research paper (scientific journal)

A non-invasive drug delivery system using claudin bider

Azusa TAKAHASHI, Masuo KONDOH, Kiyohito YAGI

YAKUGAKU ZASSHI　Vol. 131　No. 11　p. 1583-1587　2011/11

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.

Takayuki Suzuki, Tomomi Sasaki, Koyori Yano, Fuminori Sakurai, Kenji Kawabata, Masuo Kondoh, Takao Hayakawa, Kiyohito Yagi, Hiroyuki Mizuguchi

Virus research　Vol. 158　No. 1-2　p. 154-60　2011/06

Preparation of a dual claudin binder using a fragment of Clostridium perfringens enterotoxin

Azusa Takahashi, Yumiko Saito, Koji Matsuhisa, Yohei Kakamu, Miki Kodaka, Akihiro Watari, Masuo Kondoh, Kiyohito Yagi

FASEB JOURNAL　Vol. 25　2011/04　Research paper (scientific journal)

A simple screening system for claudin binders using an scFv library derived from claudin-immunized mice

Kodaka, Miki, Takahashi, Azusa, Yamaura, Toshiaki, Kakamu, Yohei, Matsuhisa, Koji, Matsushita, Kyohei, Watari, Akihiro, Kondoh, Masuo, Yagi, Kiyohito

FASEB JOURNAL　Vol. 25　2011　Research paper (scientific journal)

Biochemical analysis of a novel dual claudin binder

Kakamu, Yohei, Matsushita, Kyohei, Saito, Yumiko, Takahashi, Azusa, Matsuhisa, Koji, Watari, Akihiro, Kondoh, Masuo, Yagi, Kiyohito

FASEB JOURNAL　Vol. 25　2011　Research paper (scientific journal)

Potency of claudin-targeting as antitumor therapy

Rie Saeki, Masuo Kondoh, Hiroshi Uchida, Kiyohito Yagi

Mol. Cell. Pharmacol.　Vol. 2　No. 2　p. 47-51　2010/12　Research paper (scientific journal)

Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors

Masahiro Ushitora, Fuminori Sakurai, Tomoko Yamaguchi, Shin-ichiro Nakamura, Masuo Kondoh, Kiyohito Yagi, Kenji Kawabata, Hiroyuki Mizuguchi

JOURNAL OF CONTROLLED RELEASE　Vol. 142　No. 3　p. 431-437　2010/03　Research paper (scientific journal)

Development of high fat diet-induced obesity in femael metallothionein-null mice

Masao Sato, Takashige Kawakami, Masuo Kondoh, Masufumi Takiguchi, Yoshito Kadota, Seiichiro Himeno, Shinya Suzuki

FASEB Journal　Vol. 24　No. 7　p. 2375-2384　2010/02　Research paper (scientific journal)

Hepatotoxicity of silica nanoparticles in mice

Kiyohito Yagi, Hikaru Nishimori, Masuo Kondoh, Katsuhiro Isoda, Shin-ichi Tsunoda, Yasuo Tsutsumi

TOXICOLOGY LETTERS　Vol. 189　p. S184-S184　2009/09

Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma

Hideo Shiohira, Makiko Fujii, Naoya Koizumi, Masuo Kondoh, Yoshiteru Watanabe

Int J Pharm　Vol. 379　No. 1　p. 119-24　2009/09　Research paper (scientific journal)

Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity

Hikaru NISHIMORI, Masuo KONDOH, Katsuhiro ISODA, Yasuo TSUTSUMI, Kiyohito YAGI

Pharmazie　Vol. 64　No. 6　p. 395-397　2009/06　Research paper (scientific journal)

Silica nanoparticles as hepatotoxicants

Hikaru NISHIMORI, Masuo KONDOH, Katsuhiro ISODA, Shinichi TSUNODA, Yasuo TSUTSUMI

Eur. J. Pharm. Bipharm.　Vol. 72　No. 3　p. 496-501　2009/02　Research paper (scientific journal)

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy

Takayuki Suzuki, Fuminori Sakurai, Shin-Ichiro Nakamura, Emi Kouyama, Kenji Kawabata, Masuo Kondoh, Kiyohito Yagi, Hiroyuki Mizuguchi

MOLECULAR THERAPY　Vol. 16　No. 10　p. 1719-1726　2008/10　Research paper (scientific journal)

Induction of hepatocyte-like cells from mesenchymal stem cells and the transplantation into liver-injured rats

Yagi Kiyohito, Kojima Midori, Ikeda Etsuko, Isoda Katsuhiro, Kondoh Masuo, Ohgushi Hajime

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL　Vol. 44　2008

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy

Takayuki Suzuki, Fuminori Sakurai, Shin-Ichiro Nakamura, Emi Kouyama, Kenji Kawabata, Masuo Kondoh, Kiyohito Yagi, Hiroyuki Mizuguchi

Molecular Therapy　Vol. 16　No. 10　p. 1719-1726　2008　Research paper (scientific journal)

Effect of characteristics of compounds on maintenance of an amorphous state in solid dispersion with crospovidone.

Yusuke Shibata, Makiko Fujii, Makiko Kokudai, Shinobu Noda, Hideko Okada, Masuo Kondoh, Yoshiteru Watanabe

Journal of pharmaceutical sciences　Vol. 96　No. 6　p. 1537-47　2007/06

Claudin-4阻害分子Clostridium perfringens enterotoxin断片(C-CPE)のC末領域の機能解析

高橋 梓, 古宮 栄利子, 影澤 恵, 小山 葵, 藤井 まき子, 角田 慎一, 小泉 直也, 磯田 勝広, 渡辺 善照, 八木 清仁, 近藤 昌夫

日本薬学会年会要旨集　Vol. 127年会　No. 3　p. 90-90　2007/03

メトキシケイヒ酸2-エチルヘキシルの皮膚移行に与える2-Methacryloyloxyethylphosphorylcholine Butylmethacrylate共重合体の影響

藤井 まき子, 和久井 京, 花田 真隆, 大谷 寿子, 石川 亜紀子, 近藤 昌夫, 渡辺 善照

日本香粧品学会誌　Vol. 31　No. 1　p. 1-7　2007/03

Total synthesis and cytotoxicity of (+)- and (-)-goniodiol and 6-epi-goniodiol. Construction of α,β-unsaturated lactones by ring-closing metathesis

Katsuyuki Nakashima, Naoki Kikuchi, Daisuke Shirayama, Takuo Miki, Kazuhiro Ando, Masakazu Sono, Shinya Suzuki, Masaki Kawase, Masuo Kondoh, Masao Sato, Motoo Tori

Bulletin of the Chemical Society of Japan　Vol. 80　No. 2　p. 387-394　2007　Research paper (scientific journal)

Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors

Naoki Futakawa, Masuo Kondoh, Satoshi Ueda, Minoru Higashimoto, Masufumi Takiguchi, Shinya Suzuki, Masao Sato

Biological & Pharmaceutical Bulletin　Vol. 29　No. 10　p. 2016-2020　2006/10　Research paper (scientific journal)

Role of metal-responsive transcription factor-1 (MTF-1) in EGF-dependent DNA synthesis in primary hepatocytes

Tomoki Kimura, Norio Itoh, Tomomichi Sone, Masuo Kondoh, Keiichi Tanaka, Masakazu Isobe

JOURNAL OF CELLULAR BIOCHEMISTRY　Vol. 99　No. 2　p. 485-494　2006/10　Research paper (scientific journal)

Fluidity and tableting characteristics of a powder solid dispersion of the low melting drugs ketoprofen and ibuprofen with crospovidone.

Yusuke Shibata, Makiko Fujii, Shinobu Noda, Maiko Kokudai, Hideko Okada, Masuo Kondoh, Yoshiteru Watanabe

Drug Development and Industrial Pharmacy　Vol. 32　No. 4　p. 449-56　2006/04　Research paper (scientific journal)

Characteristics of Transcription-regulatory Elements for Gene Expression from Plasmid Vectors in Human Trophoblast Cell Lines

Komiya E, Kondoh M, Mizuguchi H, Fujii M, Utoguchi N, Nakanishi T, Watanabe Y

Placenta　Vol. 27　No. 9-10　p. 934-938　2006/04　Research paper (scientific journal)

Induction of zinc transporters by forskolin in human trophoblast BeWo cells

Asano N, Kondoh M, Ebihara C, Fujii M, Nakanishi T, Utoguchi N, Enomoto S, Tanaka K, Watanabe Y

Reproductive Toxicology　Vol. 21　No. 3　p. 285-291　2006/04　Research paper (scientific journal)

Effect of N-methyl-2-pyrrolidone on the skin permeation of estradiol and levonorgestrel from adhesive strips prepared using Eudragit EPO

Makiko Fujii, Atsuko Koizumi, Ritsuko Suzuki, Junko Nio, Masuo Kondoh, Yoshiteru Watanabe

Journal of Drug Delivery Science and Technology　Vol. 16　p. 121-125　2006/03　Research paper (scientific journal)

Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin

Chiaki Ebihara, Masuo Kondoh, Naoki Hasuike, Motoki Harada, Hiroyuki Mizuguchi, Yasuhiko Horiguchi, Makiko Fujii, Yoshiteru Watanabe

Journal of Pharmacology and Experimental Therapy　Vol. 316　No. 1　p. 255-60　2006/01　Research paper (scientific journal)

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4

Azusa Takahashi, Masuo Kondoh, Akane Masuyama, Makiko Fujii, Hiroyuki Mizuguchi, Yasuhiko Horiguchi, Yoshiteru Watanabe

Journal of Controlled Release　Vol. 108　No. 1　p. 56-62　2005/11　Research paper (scientific journal)

Induction of apoptosis by new ent-kaurene-type diterpenoids isolated from the New Zealand liverwort Jungermannia species.

Masuo Kondoh, Fumihiro Nagashima, Ikue Suzuki, Motoki Harada, Makiko Fujii, Yoshinori Asakawa, Yoshiteru Watanabe

Planta Medica　Vol. 71　No. 11　p. 1005-9　2005/11　Research paper (scientific journal)

メトキシケイヒ酸オクチルの皮膚浸透に及ぼす乳化剤の影響

藤井 まき子, 和久井 京, 石川 亜紀子, 花田 真隆, 近藤 昌夫, 渡辺 善照

日本香粧品学会誌　Vol. 29　No. 3　p. 249-250　2005/09

Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin

Akane Masuyama, Masuo Kondoh, Hirotoshi Seguchi, Azusa Takahashi, Motoki Harada, Makiko Fujii, Hiroyuki Mizuguchi, Yasuhiko Horiguchi, Yoshiteru Watanabe

Journal of Pharmacology and Experimental Therapy　Vol. 314　No. 2　p. 789-95　2005/08　Research paper (scientific journal)

Evaluation of the compaction properties of a solid dispersion of indomethacin with crospovidone by tableting process analyzer.

Yusuke Shibata, Makiko Fujii, Hideko Okada, Shinobu Noda, Masuo Kondoh, Yoshiteru Watanabe

Chemical & Pharmaceutical Bulletin　Vol. 53　No. 7　p. 759-763　2005/07　Research paper (scientific journal)

Diphenhydramine(DPH)の皮膚移行に及ぼす2-methacryloyloxyethyl phosphorylcholine butyl methacrylate copolymer(PMB)の影響

石川 亜紀子, 森本 久美, 近藤 昌夫, 藤井 まき子, 渡辺 善照

Drug Delivery System　Vol. 20　No. 3　p. 328-328　2005/05

Novel kaurane-type diterpenoids from the New Zealand liverwort Jungermannia species.

Fumihiro Nagashima, Masuo Kondoh, Makiko Fujii, Shigeru Takaoka, Yoshiteru Watanabe, Yoshinori Asakawa

Tetrahedron　Vol. 61　No. 19　p. 4531-4544　2005/05　Research paper (scientific journal)

Clostridium perfringens enterotoxinのC末断片を利用したclaudin指向性分子の創製

海老原 千晶, 近藤 昌夫, 原田 東樹, 高橋 梓, 藤井 まき子, 渡辺 善照

Drug Delivery System　Vol. 20　No. 3　p. 302-302　2005/05

ウェルシュ菌エンテロトキシンC末断片の吸収促進作用におけるN末領域の役割

原田 東樹, 近藤 昌夫, 高橋 梓, 藤井 まき子, 渡辺 善照

Drug Delivery System　Vol. 20　No. 3　p. 314-314　2005/05

Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone.

Makiko Fujii, Hideko Okada, Yusuke Shibata, Honami Teramachi, Masuo Kondoh, Yoshiteru Watanabe

International journal of pharmaceutics　Vol. 293　No. 1-2　p. 145-53　2005/04/11

Activation of caspase-3 in HL-60 cells treated with pyrithione and zinc.

Masuo Kondoh, Emi Tasaki, Masufumi Takiguchi, Minoru Higashimoto, Yoshiteru Watanabe, Masao Sato

Biological & Pharmceutical Bulletin　Vol. 28　No. 4　p. 757-9　2005/04　Research paper (scientific journal)

A novel strategy for the enhancement of drug absorption using a claudin modulator.

Masuo Kondoh, Akane Masuyama, Azusa Takahashi, Nagayoshi Asano, Hiroyuki Mizuguchi, Naoya Koizumi, Makiko Fujii, Takao Hayakawa, Yasuhiko Horiguchi, Yoshiteru Watanbe

Molecular Pharmacology　Vol. 67　No. 3　p. 749-756　2005/03　Research paper (scientific journal)

Activation of p38 mitogen-activated protein kinase during ent-11alpha-hydroxy-16-kauren-15-one-induced apoptosis in human leukemia HL-60 cells.

Masuo Kondoh, Ikue Suzuki, Motoki Harada, Fumihiro Nagashima, Makiko Fujii, Yoshinori Asakawa, Yoshiteru Watanabe

Planta medica　Vol. 71　No. 3　p. 275-7　2005/03

Epinephrine is an enhancer of rat intestinal absorption.

Yuko Kamio, Yurika Saito, Naoki Utoguchi, Masuo Kondoh, Naoya Koizumi, Makiko Fujii, Yoshiteru Watanabe

Journal of Controlled Release　Vol. 102　No. 3　p. 563-8　2005/02　Research paper (scientific journal)

Efficient gene transfer into human trophoblast cells with adenovirus vector containing chimeric type 5 and 35 fiber protein.

Naoya Koizumi, Hiroyuki Mizuguchi, Masuo Kondoh, Makiko Fujii, Takao Hayakawa, Yoshiteru Watanabe

Biological & Pharmaceutical Bulletin　Vol. 27　No. 12　p. 2046-8　2004/12　Research paper (scientific journal)

Expression profiles of zinc transporters in rodent placental models

Nagayoshi Asano, Masuo Kondoh, Chiaki Ebihara, Makiko Fujii, Tsuyoshi Nakanishi, MJ Soares, Emi Nakashima, Keiichi Tanaka, Masao Sato, Yoshiteru Watanabe Y

Toxicology Letters　Vol. 154　No. 1-2　p. 45-53　2004/12　Research paper (scientific journal)

A novel method for predicting disintegration time in the mouth of rapidly disintegrating tablet by compaction analysis using TabAll.

Yusuke Shibata, Yoshinobu Yamamoto, Makiko Fujii, Masuo Kondoh, Yoshiteru Watanabe

Chemical & Pharmaceutical Bulletin　Vol. 52　No. 11　p. 1394-5　2004/11　Research paper (scientific journal)

Classical conditioning of metallothionein synthesis in mice.

Masuo Kondoh, Daisuke Kodama, Yoshiteru Watanabe, Masao Sato

Journal of Health Science　Vol. 50　No. 4　p. 413-416　2004/08　Research paper (scientific journal)

An ent-kaurene diterpene enhances apoptosis induced by tumor necrosis factor in human leukemia cells.

Ikue Suzuki, Masuo Kondoh, Motoki Harada, Naoya Koizumi, Makiko Fujii, Fumihiro Nagashima, Yoshinori Asakawa, Yoshiteru Watanabe

Planta medica　Vol. 70　No. 8　p. 723-7　2004/08

Activation of a 36-kDa myelin basic protein kinase during cadmium-induced apoptosis in human leukemia HL-60 cells.

Masuo Kondoh, Yoshiteru Watanabe, Masao Sato

Journal of Health Science　Vol. 50　No. 3　p. 296-300　2004/06　Research paper (scientific journal)

オイドラギッドEPOを用いた女性ホルモン貼付剤の調製

藤井 まき子, 木下 悠子, 小泉 温子, 近藤 昌夫, 渡辺 善照

Drug Delivery System　Vol. 19　No. 3　p. 314-314　2004/05

Effect of N-methyl-2-pyrrolidone on skin permeation of estradiol.

Atsuko Koizumi, Makiko Fujii, Masuo Kondoh, Yoshiteru Watanabe

European Journal of Pharmceutics and Biopharmaceutics　Vol. 57　No. 3　p. 473-8　2004/05　Research paper (scientific journal)

A comparison of apoptosis and necrosis induced by ent-kaurene-type diterpenoids in HL-60 cells.

Ikue Suzuki, Masuo Kondoh, Fumihiro Nagashima, Makiko Fujii, Yoshinori Asakawa, Yoshiteru Watanabe

Planta Medica　Vol. 70　No. 5　p. 401-6　2004/05　Research paper (scientific journal)

Induction of metallothionein synthesis by endoplasmic reticulum stress in mice.

Masuo Kondoh, Manami Tsukada, Maki Kuronaga, Minoru Higashimoto, Masufumi Takiguchi, Seiichiro Himeno, Yoshiteru Watanabe, Masao Sato

Toxicology Letters　Vol. 148　No. 1-2　p. 133-139　2004/03　Research paper (scientific journal)

New ent-kaurene-type diterpenoids possessing cytotoxicity from the New Zealand liverwort Jungermannia species.

Fumihiro Nagashima, Wakana Kasai, Masuo Kondoh, Makiko Fujii, Yoshiteru Watanabe, J. E. Branngins, Yoshinori Asakawa

Chemical & Pharmaceutical Bulletin　Vol. 51　No. 10　p. 1189-1192　2003/10　Research paper (scientific journal)

Antioxidant property of metallothionein in fasted mice.

Masuo Kondoh, Kaori Kamada, Maki Kuronaga, Minoru Higashimoto, Masufumi Takiguchi, Yoshiteru Watanabe, Masao Sato

Toxicological Letters　Vol. 143　No. 3　p. 301-306　2003/08　Research paper (scientific journal)

アクリル酸系ポリマーを用いた時間制御型アミノフィリン放出錠剤の調製と評価

角田 寛子, 鹿児島 卓也, 向井 麦, 近藤 昌夫, 藤井 まき子, 渡辺 善照

Drug Delivery System　Vol. 18　No. 3　p. 275-275　2003/05

Property of metallothionein as a Zn pool differs depending on the induced condition of metallothionein.

Masuo Kondoh, Nagisa Imada, Kaori Kamada, Rie Tsukahara, Minoru Higashimoto, Masufumi Takiguchi, Yoshiteru Watanabe, Masao Sato

Toxicology Letters　Vol. 142　No. 1-2　p. 11-18　2003/04　Research paper (scientific journal)

Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells.

Saeko Araragi, Masuo Kondoh, Masaki Kawase, Sayaka Saito, Minoru Higashimoto, Masao Sato

Toxicology　Vol. 184　No. 1　p. 1-9　2003/02　Research paper (scientific journal)

Enhancement of MT synthesis by leptin in fasted mice

Masuo Kondoh, Rie Tsukahara, Maki Kuronaga, Minoru Higashimoto, Masufumi Takiguchi, Masao Sato

Life Sciences　Vol. 71　No. 20　p. 2425-2433　2002/10/04　Research paper (scientific journal)

Different responses of metallothionein and leptin induced in the mouse by fasting stress.

Minoru Higashimoto, Mayumi Sano, Masuo Kondoh, Masao Sato

Biological Trace Element Research　Vol. 89　No. 1　p. 75-84　2002/10　Research paper (scientific journal)

Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata Nees.

Fumihiro Nagashima, Masuo Kondoh, Toshinari Uematsu, Akiko Nishiyama, Sayaka Saito, Masao Sato, Yoshinori Asakawa

Chemical & Pharmaceutical Bulletin　Vol. 50　No. 6　p. 808-813　2002/06　Research paper (scientific journal)

Cadmium induces apoptosis partly via the caspase-9 activation in HL-60 cells.

Masuo Kondoh, Saeko Araragi, Katsuya Sato, Minoru Higashimoto, Masufumi Takiguchi, Masao Sato

Toxicology　Vol. 170　No. 1-2　p. 111-117　2002/01　Research paper (scientific journal)

Recent studies on metallothionein: Protection against toxicity of heavy metals and oxygen free radicals

Masao Sato, Masuo Kondoh

Tohoku Journal of Experimental Medicine　Vol. 196　No. 1　p. 9-22　2002/01　Research paper (scientific journal)

Specific induction of metallothionein synthesis by mitochondrial oxidative stress

Masuo Kondoh, Yuko Inoue, Saori Atagi, Naoki Futakawa, Minoru Higashimoto, Masao Sato

Life Sciences　Vol. 69　No. 18　p. 2137-2146　2001/09/21　Research paper (scientific journal)

Cytochrome c release from mitochondria induced by cadmium.

Masuo Kondoh, Satoko Ogasawara, Saeko Araragi, Minoru Higashimoto, Masao Sato

Journal of Health Science　Vol. 47　No. 1　p. 78-82　2001/02　Research paper (scientific journal)

Growth inhibition of human leukemia HL-60 cells by an antisense phosphodiester oligonucleotide encapsulated into fusogenic liposome.

Masuo Kondoh, Takahiro Matsuyama, Ryo Suzuki, Hiroyuki Mizuguchi, Tsuyoshi Nakanishi, Shinsaku Nakagawa, Yasuo Tsutsumi, Mahito Nakanishi, Masao Sato, Tadanori Mayumi

Biological & Pharmaceutical Bulletin　Vol. 23　No. 8　p. 1011-1013　2000/08　Research paper (scientific journal)

Synthesis of pironetin and related analogs: Studies on structure-activity relationships as tubulin assembly inhibitors.

Hiroyuki Watanabe, Hidenori Watanabe, Takeo Usui, Masuo Kondoh, Hiroyuki Osada, Takeshi Kitahara

Journal of Antibiotics　Vol. 53　No. 5　p. 540-545　2000/05　Research paper (scientific journal)

Inhibition mechanism and structure-activity relationships of anti-microtubule compounds, pironetin and its derivatives.

Takeo Usui, Masuo Kondoh, Hiroyuki Osada

Clinical Cancer Research　1999/11

A novel vaccine delivery system using immunopotentiating fusogenic liposomes.

Akira Hayashi, Tsuyoshi Nakanishi, Jun Kunisawa, Masuo Kondoh, Susumu Imazu, Yasuo Tsutsumi, Keiichi Tanaka, Hiromi Fujiwara, Toshiyuki Hamaoka, Tadanori Mayumi

Biochemical and Biophysical Research Communications　Vol. 261　No. 3　p. 824-828　1999/08　Research paper (scientific journal)

A novel vaccine delivery system using immunopotentiating fusogenic liposomes.

Hayashi A, Nakanishi T, Kunisawa J, Kondoh M, Imazu S, Tsutsumi Y, Tanaka K, Fujiwara H, Hamaoka T, Mayumi T

Biochem Biophys Res Commun　Vol. 261　No. 3　p. 824-828　1999/08

Apoptosis induction via microtubule disassembly by an antitumor compound, pironetin.

Masuo Kondoh, Takeo Usui, Takaaki Nishikiori, Tadanori Mayumi, Hiroyuki Osada

Biochemical Journal　Vol. 340　No. 2　p. 411-416　1999/06　Research paper (scientific journal)

Fusion of Sendai virus with liposome depends on only F protein, but not HN protein

H Mizuguchi, T Nakanishi, M Kondoh, T Nakagawa, M Nakanishi, T Matsuyama, Y Tsutsumi, S Nakagawa, T Mayumi

VIRUS RESEARCH　Vol. 59　No. 2　p. 191-201　1999/02　Research paper (scientific journal)

Gene delivery systems using the Sendai virus

Mahito Nakanishi, Hiroyuki Mizuguchi, Ken-Ichi Ashihara, Takao Senda, Akiko Eguchi, Akiko Watabe, Tsuyoshi Nakanishi, Masuo Kondo, Tetsuhiko Nakagawa, Akinori Masago, Jun Okabe, Shigeharu Ueda, Tadanori Mayumi, Takao Hayakawa

Molecular Membrane Biology　Vol. 16　No. 1　p. 123-127　1999　Research paper (international conference proceedings)

Tryprostain A, a specific and novel inhibitor of microtubule assembly.

Takeo Usui, Masuo Kondoh, Cheng-Bin Cui, Tadanori Mayumi, Hiroyuki Osada

Biochemical Journal　Vol. 333　No. 3　p. 543-548　1998/08　Research paper (scientific journal)

Effects of tryprostatin derivatives on the microtubule assembly in vitro and in situ.

Masuo Kondoh, Takeo Usui, Tadanori Mayumi, Hiroyuki Osada

Journal of Antibiotics　Vol. 51　No. 8　p. 801-804　1998/08　Research paper (scientific journal)

Cell cycle arrest and antitumor activity of pironetin and its derivatives.

Masuo Kondoh, Takeo Usui, Shinichi Kobayashi, Kouichi Tsuchiya, Nobuyoshi Shimada, Tadanori Mayumi, Hiroyuki Osada

Cancer Letters　Vol. 126　No. 1　p. 29-32　1998/04　Research paper (scientific journal)

Biosynthesis of poly (3-hydroxyalkanoic acid) copolymer from CO2 in Pseudomonas acidophila through introduction of the DNA fragment responsible for chemolithoautotrophic growth of Alcaligenes hydrogenophilus.

Kiyohito Yagi, Izuru Miyawaki, Ayumi Kayashita, Masuo Kondo, Yoshiharu Kitano, Yuki Murakami, Isamu Maeda, Fusako Umeda, Yoshiharu Miura, Masata Kawase, Tadashi Mizoguchi

Appl Environ Microbiol　1996/10　Research paper (scientific journal)