JA

Profile

Research

Social

Other

Mizuguchi Kenji

水口　賢司

Institute for Protein Research, Professor

keyword drug design，network biology，omics，computational biology，disease biology，data integration，database，drug discovery，protein interaction，protein structure

Education

  • 1992/04 - 1995/07, Kyoto University, Department of Chemistry
  • 1990/04 - 1992/03, Kyoto University, Department of Chemistry
  • 1986/04 - 1990/03, Kyoto University, Faculty of Science

Research History

  • 2019/10 - Present, Institute for Protein Research, Osaka University, Professor
  • 2019/07 - 2024/03, National Institutes of Biomedical Innovation, Health and Nutrition, Artificial Intelligence Center for Health and Biomedical Research, Director
  • 2013/05 - 2024/03, National Institutes of Biomedical Innovation, Health and Nutrition, Laboratory of In silico design, Research Group Head
  • 2006/10 - 2021/08, National Institutes of Biomedical Innovation, Health and Nutrition, Laboratory of Bioinformatics, Research Group Head
  • 2004/10 - 2006/09, University of Cambridge, Department of Applied Mathematics and Theoretical Physics, Lecturer
  • 2000/06 - 2006/09, University of Cambridge, Department of Biochemistry, Research Group Head
  • 1998/10 - 2000/05, University of Cambridge, Department of Biochemistry, Postdoctoral Research Associate
  • 1996/10 - 1998/09, University of Cambridge, Department of Biochemistry, HFSP Long-term Fellow
  • 1995/09 - 1996/09, Birkbeck, University of London, Department of Crystallography, Visiting Scientist

Research Areas

  • Life sciences, Systems genomics, bioinformatics
  • Informatics, Biological, health, and medical informatics, bioinformatics

Professional Memberships

  • 情報計算化学生物学会（CBI学会）
  • 日本メディカルAI学会
  • 日本バイオインフォマティクス学会
  • 日本生物物理学会

Papers

  • Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology, Hanako Yoshimura,Yoshito Takeda,Yuya Shirai,Makoto Yamamoto,Daisuke Nakatsubo,Saori Amiya,Takatoshi Enomoto,Reina Hara,Yuichi Adachi,Ryuya Edahiro,Moto Yaga,Kentaro Masuhiro,Taro Koba,Miho Itoh-Takahashi,Mana Nakayama,So Takata,Yuki Hosono,Sho Obata,Masayuki Nishide,Akinori Hata,Masahiro Yanagawa,Satoko Namba,Michio Iwata,Momoko Hamano,Haruhiko Hirata,Shohei Koyama,Kota Iwahori,Izumi Nagatomo,Yasuhiko Suga,Kotaro Miyake,Takayuki Shiroyama,Kiyoharu Fukushima,Shinji Futami,Yujiro Naito,Takahiro Kawasaki,Kenji Mizuguchi,Yusuke Kawashima,Yoshihiro Yamanishi,Jun Adachi,Mari Nogami-Itoh,Shigeharu Ueki,Atsushi Kumanogoh, Journal of Allergy and Clinical Immunology, Elsevier BV, 2024/03
  • Structural and accessibility studies highlight the differential binding of clemizole to TRPC5 and TRPC6, Uzma Saqib,Isaac S. Demaree,Alexander G. Obukhov,Mirza S. Baig,Mohd Shahnawaz Khan,Nojood Altwaijry,Mochammad Arfin Fardiansyah Nasution,Kenji Mizuguchi,Krishnan Hajela, Journal of Biomolecular Structure and Dynamics, 2024/01/27
  • Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information, Mei Tomoto,Yohei Mineharu,Noriaki Sato,Yoshinori Tamada,Mari Nogami-Itoh,Masataka Kuroda,Jun Adachi,Yoshito Takeda,Kenji Mizuguchi,Atsushi Kumanogoh,Yayoi Natsume-Kitatani,Yasushi Okuno, Scientific Reports, Springer Science and Business Media LLC, Vol. 14, No. 1, 2024/01/15
  • Impact of Hydrogen Bonding on P-Glycoprotein Efflux Transport as Revealed by Evaluation of a De Novo Prediction Model, Yulong Gou,Suyong Re,Kenji Mizuguchi,Chioko Nagao, ACS Medicinal Chemistry Letters, American Chemical Society (ACS), 2023/12/21
  • Attention network for predicting T-cell receptor–peptide binding can associate attention with interpretable protein structural properties, Kyohei Koyama,Kosuke Hashimoto,Chioko Nagao,Kenji Mizuguchi, Frontiers in Bioinformatics, Frontiers Media SA, Vol. 3, 2023/12/18
  • Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross-sectional study., Chiharu Iwasaka,Hinako Nanri,Takashi Nakagata,Harumi Ohno,Kumpei Tanisawa,Kana Konishi,Haruka Murakami,Koji Hosomi,Jonguk Park,Yosuke Yamada,Rei Ono,Kenji Mizuguchi,Jun Kunisawa,Motohiko Miyachi, Geriatrics & gerontology international, 2023/12/14
  • Effects of energy loads on energy and nutrient absorption rates and gut microbiome in humans: A randomized crossover trial, Eiichi Yoshimura,Yuka Hamada,Yoichi Hatamoto,Takashi Nakagata,Hinako Nanri,Yui Nakayama,Takanori Hayashi,Ippei Suzuki,Takafumi Ando,Kazuko Ishikawa‐Takata,Shigeho Tanaka,Rei Ono,Jonguk Park,Koji Hosomi,Kenji Mizuguchi,Jun Kunisawa,Motohiko Miyachi, Obesity, Wiley, 2023/11/05
  • Changes in Fecal Gut Microbiome of Home Healthcare Patients with Disabilities through Consumption of Malted Rice Amazake, Suzumi Kageyama,Rikako Inoue,Jonguk Park,Koji Hosomi,Hitomi Yumioka,Tomo Suka,Kazuaki Teramoto,A. Yasmin Syauki,Miki Doi,Haruka Sakaue,Miyuu Miyake,Kenji Mizuguchi,Jun Kunisawa,Yasuyuki Irie, Physiological Genomics, American Physiological Society, 2023/09/11
  • Ramen Consumption and Gut Microbiota Diversity in Japanese Women: Cross-Sectional Data from the NEXIS Cohort Study, Jonguk Park,Hiroto Bushita,Ayatake Nakano,Ai Hara,Hiroshi M. Ueno,Naoki Ozato,Koji Hosomi,Hitoshi Kawashima,Yi-An Chen,Attayeb Mohsen,Harumi Ohno,Kana Konishi,Kumpei Tanisawa,Hinako Nanri,Haruka Murakami,Motohiko Miyachi,Jun Kunisawa,Kenji Mizuguchi,Michihiro Araki, Microorganisms, MDPI AG, Vol. 11, No. 8, p. 1892-1892, 2023/07/26
  • Gut microbiota alternation with training periodization and physical fitness in Japanese elite athletes, Nobuhiko Akazawa,Mariko Nakamura,Nobuhiko Eda,Haruka Murakami,Takashi Nakagata,Hinako Nanri,Jonguk Park,Koji Hosomi,Kenji Mizuguchi,Jun Kunisawa,Motohiko Miyachi,Masako Hoshikawa, Frontiers in Sports and Active Living, Frontiers Media SA, Vol. 5, 2023/07/14
  • DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis Platform, Hitoshi Kawashima,Reiko Watanabe,Tsuyoshi Esaki,Masataka Kuroda,Chioko Nagao,Yayoi Natsume-Kitatani,Rikiya Ohashi,Hiroshi Komura,Kenji Mizuguchi, Journal of Medicinal Chemistry, American Chemical Society (ACS), 2023/07/14
  • Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways, Ahmed B. Alarabi,Attayab Mohsen,Ziyad Ben Taleb,Kenji Mizuguchi,Fatima Z. Alshbool,Fadi T. Khasawneh, Life Sciences, Elsevier BV, Vol. 323, p. 121694-121694, 2023/06
  • Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles, Martin,Reiko Watanabe,Kosuke Hashimoto,Kazuma Higashisaka,Yuya Haga,Yasuo Tsutsumi,Kenji Mizuguchi, ACS Nano, 2023/05/30
  • Characteristic Gut Bacteria in High Barley Consuming Japanese Individuals without Hypertension, Satoko Maruyama,Tsubasa Matsuoka,Koji Hosomi,Jonguk Park,Mao Nishimura,Haruka Murakami,Kana Konishi,Motohiko Miyachi,Hitoshi Kawashima,Kenji Mizuguchi,Toshiki Kobayashi,Tadao Ooka,Zentaro Yamagata,Jun Kunisawa, Microorganisms, Vol. 11, No. 5, 2023/05/09
  • Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines, Yosui Nojima,Masahiko Aoki,Suyong Re,Hidekazu Hirano,Yuichi Abe,Ryohei Narumi,Satoshi Muraoka,Hirokazu Shoji,Kazufumi Honda,Takeshi Tomonaga,Kenji Mizuguchi,Narikazu Boku,Jun Adachi, Computational and Structural Biotechnology Journal, Elsevier BV, 2023/03
  • RDFization of Interview Forms for Effective Use of Pharmaceutical Documents, Nagao Chioko,Kamada Mayumi,Nakatsui Masahiko,Fukagawa Akiko,Katayama Toshiaki,Kawashima Shuichi,Mizuguchi Kenji,Abe Rika, Japanese Journal of Drug Informatics, Japanese Society of Drug Informatics, Vol. 24, No. 4, p. 187-195, 2023/02/28
  • DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein–protein interactions, Kazuyoshi Ikeda,Yuta Maezawa,Tomoki Yonezawa,Yugo Shimizu,Toshiyuki Tashiro,Satoru Kanai,Nobuyoshi Sugaya,Yoshiaki Masuda,Naoko Inoue,Tatsuya Niimi,Keiichi Masuya,Kenji Mizuguchi,Toshio Furuya,Masanori Osawa, Frontiers in Chemistry, Frontiers Media SA, Vol. 10, 2023/01/09
  • Prediction of the Contribution Ratio of a Target Metabolic Enzyme to Clearance from Chemical Structure Information, Reiko Watanabe,Toshio Kawata,Shinya Ueda,Takumi Shinbo,Mitsuo Higashimori,Yayoi Natsume-Kitatani,Kenji Mizuguchi, Molecular Pharmaceutics, American Chemical Society (ACS), 2022/12/20
  • Identification of Human Gut Microbiome Associated with Enterolignan Production, Kento Sawane,Koji Hosomi,Jonguk Park,Kouta Ookoshi,Hinako Nanri,Takashi Nakagata,Yi-An Chen,Attayeb Mohsen,Hitoshi Kawashima,Kenji Mizuguchi,Motohiko Miyachi,Jun Kunisawa, Microorganisms, MDPI AG, Vol. 10, No. 11, p. 2169-2169, 2022/10/31
  • Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and CD28‐bound states, Yuhi Hosoe,Yohei Miyanoiri,Suyong Re,Saki Ochi,Yuya Asahina,Toru Kawakami,Masataka Kuroda,Kenji Mizuguchi,Masayuki Oda, The FEBS Journal, Wiley, Vol. 290, No. 9, p. 2366-2378, 2022/10/25
  • Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota, Koji Hosomi,Mayu Saito,Jonguk Park,Haruka Murakami,Naoko Shibata,Masahiro Ando,Takahiro Nagatake,Kana Konishi,Harumi Ohno,Kumpei Tanisawa,Attayeb Mohsen,Yi-An Chen,Hitoshi Kawashima,Yayoi Natsume-Kitatani,Yoshimasa Oka,Hidenori Shimizu,Mari Furuta,Yoko Tojima,Kento Sawane,Azusa Saika,Saki Kondo,Yasunori Yonejima,Haruko Takeyama,Akira Matsutani,Kenji Mizuguchi,Motohiko Miyachi,Jun Kunisawa, Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1, p. 4477-4477, 2022/08/18
  • TargetMine 2022: A new vision into drug target analysis., Yi-An Chen,Rodolfo S Allendes Osorio,Kenji Mizuguchi, Bioinformatics (Oxford, England), 2022/07/27
  • Integrative Network Modeling Highlights the Crucial Roles of Rho-GDI Signaling Pathway in the Progression of Non-Small Cell Lung Cancer., Saransh Gupta,Haswanth Vundavilli,Rodolfo S Allendes Osorio,Mari N Itoh,Attayeb Mohsen,Aniruddha Datta,Kenji Mizuguchi,Lokesh P Tripathi, IEEE journal of biomedical and health informatics, Vol. PP, 2022/07/12
  • Snaq: A Dynamic Snakemake Pipeline for Microbiome Data Analysis With QIIME2, Attayeb Mohsen,Yi-An Chen,Rodolfo S. Allendes Osorio,Chihiro Higuchi,Kenji Mizuguchi, Frontiers in Bioinformatics, Frontiers Media SA, Vol. 2, p. 893933-893933, 2022/07/01
  • Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids., Jonguk Park,Koji Hosomi,Hitoshi Kawashima,Yi-An Chen,Attayeb Mohsen,Harumi Ohno,Kana Konishi,Kumpei Tanisawa,Masako Kifushi,Masato Kogawa,Haruko Takeyama,Haruka Murakami,Tetsuya Kubota,Motohiko Miyachi,Jun Kunisawa,Kenji Mizuguchi, Nutrients, Vol. 14, No. 10, 2022/05/16
  • Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets, Ahmed B. Alarabi,Attayeb Mohsen,Kenji Mizuguchi,Fatima Z. Alshbool,Fadi T. Khasawneh, BMC Medical Genomics, Springer Science and Business Media {LLC}, Vol. 15, No. 1, 2022/04
  • Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan, Yumiko Ikubo,Takayuki Jujo Sanada,Koji Hosomi,Jonguk Park,Akira Naito,Hiroki Shoji,Tomoko Misawa,Rika Suda,Ayumi Sekine,Toshihiko Sugiura,Ayako Shigeta,Hinako Nanri,Seiichiro Sakao,Nobuhiro Tanabe,Kenji Mizuguchi,Jun Kunisawa,Takuji Suzuki,Koichiro Tatsumi, BMC Pulmonary Medicine, Springer Science and Business Media LLC, Vol. 22, No. 1, 2022/04
  • Classification of the Occurrence of Dyslipidemia Based on Gut Bacteria Related to Barley Intake, Satoko Maruyama,Tsubasa Matsuoka,Koji Hosomi,Jonguk Park,Mao Nishimura,Haruka Murakami,Kana Konishi,Motohiko Miyachi,Hitoshi Kawashima,Kenji Mizuguchi,Toshiki Kobayashi,Tadao Ooka,Zentaro Yamagata,Jun Kunisawa, Frontiers in Nutrition, Frontiers Media SA, Vol. 9, 2022/03/24
  • α-Amino acid and peptide synthesis using catalytic cross-dehydrogenative coupling, Taro Tsuji,Kayoko Hashiguchi,Mana Yoshida,Tetsu Ikeda,Yunosuke Koga,Yusaku Honda,Tsukushi Tanaka,Suyong Re,Kenji Mizuguchi,Daisuke Takahashi,Ryo Yazaki,Takashi Ohshima, Nature Synthesis, Springer Science and Business Media LLC, Vol. 1, No. 4, p. 304-312, 2022/03/14
  • Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer, Hidekazu Hirano,Yuichi Abe,Yosui Nojima,Masahiko Aoki,Hirokazu Shoji,Junko Isoyama,Kazufumi Honda,Narikazu Boku,Kenji Mizuguchi,Takeshi Tomonaga,Jun Adachi, Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1, 2022/03
  • Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study, Tsubasa Matsuoka,Koji Hosomi,Jonguk Park,Yuka Goto,Mao Nishimura,Satoko Maruyama,Haruka Murakami,Kana Konishi,Motohiko Miyachi,Hitoshi Kawashima,Kenji Mizuguchi,Toshiki Kobayashi,Hiroshi Yokomichi,Jun Kunisawa,Zentaro Yamagata, BMC Nutrition, Springer Science and Business Media LLC, Vol. 8, No. 1, p. 23-23, 2022/03
  • The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma, TAKEHIRO OTOSHI,TATSUYA NAGANO,JONGUK PARK,KOJI HOSOMI,TOMOYA YAMASHITA,MOTOKO TACHIHARA,TOKIKO TABATA,REINA SEKIYA,YUGO TANAKA,KAZUYUKI KOBAYASHI,KENJI MIZUGUCHI,TOMOO ITOH,YOSHIMASA MANIWA,JUN KUNISAWA,YOSHIHIRO NISHIMURA, Anticancer Research, Anticancer Research USA Inc., Vol. 42, No. 3, p. 1589-1598, 2022/03
  • Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota, Yoshimi Miki,Yoshitaka Taketomi,Yuh Kidoguchi,Kei Yamamoto,Kazuaki Muramatsu,Yasumasa Nishito,Jonguk Park,Koji Hosomi,Kenji Mizuguchi,Jun Kunisawa,Tomoyoshi Soga,Eric Boilard,Siddabasave Gowda B. Gowda,Kazutaka Ikeda,Makoto Arita,Makoto Murakami, JCI Insight, American Society for Clinical Investigation, Vol. 7, No. 2, 2022/01/25
  • Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide, Daiki Yamane,Satsuki Onitsuka,Suyong Re,Hikaru Isogai,Rui Hamada,Tadanari Hiramoto,Eiji Kawanishi,Kenji Mizuguchi,Naoya Shindo,Akio Ojida, Chemical Science, Royal Society of Chemistry (RSC), Vol. 13, No. 10, p. 3027-3034, 2022
  • Flavivirus recruits the valosin-containing protein (VCP)/NPL4 complex to induce stress granule disassembly for efficient viral genome replication, Masashi Arakawa,Keisuke Tabata,Kotaro Ishida,Makiko Kobayashi,Arisa Arai,Tomohiro Ishikawa,Ryosuke Suzuki,Hiroaki Takeuchi,Lokesh P. Tripathi,Kenji Mizuguchi,Eiji Morita, Journal of Biological Chemistry, Elsevier BV, p. 101597-101597, 2022/01
  • Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study, Suzumi Kageyama,Rikako Inoue,Koji Hosomi,Jonguk Park,Hitomi Yumioka,Tomo Suka,Yoshihiro Kurohashi,Kazuaki Teramoto,A. Yasmin Syauki,Miki Doi,Haruka Sakaue,Kenji Mizuguchi,Jun Kunisawa,Yasuyuki Irie, Nutrients, MDPI AG, Vol. 13, No. 12, p. 4466-4466, 2021/12/14
  • Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts, Jonguk Park,Kumiko Kato,Haruka Murakami,Koji Hosomi,Kumpei Tanisawa,Takashi Nakagata,Harumi Ohno,Kana Konishi,Hitoshi Kawashima,Yi-An Chen,Attayeb Mohsen,Jin-zhong Xiao,Toshitaka Odamaki,Jun Kunisawa,Kenji Mizuguchi,Motohiko Miyachi, BMC Microbiology, Springer Science and Business Media LLC, Vol. 21, No. 1, p. 151-151, 2021/12
  • Categorization of the Ocular Microbiome in Japanese Stevens–Johnson Syndrome Patients With Severe Ocular Complications, Mayumi Ueta,Koji Hosomi,Jonguk Park,Kenji Mizuguchi,Chie Sotozono,Shigeru Kinoshita,Jun Kunisawa, Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 11, p. 741654-741654, 2021/11/19
  • Deep Learning Prediction of Adverse Drug Reactions in Drug Discovery Using Open TG–GATEs and FAERS Databases, Attayeb Mohsen,Lokesh P. Tripathi,Kenji Mizuguchi, Frontiers in Drug Discovery, Frontiers Media SA, Vol. 1, 2021/10/27
  • Relationship between Human Gut Microbiota and Nutrition Intake in Hypertensive Discordant Monozygotic Twins, Rie Tomizawa,Jonguk Park,Natsuko Matsumoto,Koji Hosomi,Hitoshi Kawashima,Kenji Mizuguchi,Jun Kunisawa,Chika Honda, Journal of Hypertension: Open Access, Vol. 10, No. 8, 2021/08
  • Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice, Juneyoung Lee,Attayeb Mohsen,Anik Banerjee,Louise D. McCullough,Kenji Mizuguchi,Motomu Shimaoka,Hiroshi Kiyono,Eun Jeong Park, International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 7, p. 3544-3544, 2021/03/29
  • Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins, Natsuko Matsumoto,Jonguk Park,Rie Tomizawa,Hitoshi Kawashima,Koji Hosomi,Kenji Mizuguchi,Chika Honda,Ritsuko Ozaki,Yoshinori Iwatani,Mikio Watanabe,Jun Kunisawa, Medicina, MDPI AG, Vol. 57, No. 3, p. 275-275, 2021/03/16
  • Network Modeling and Inference of Peroxisome Proliferator-Activated Receptor Pathway in High fat diet-linked Obesity., Haswanth Vundavilli,Lokesh P.Tripathi,Aniruddha Datta,Kenji Mizuguchi, Journal of theoretical biology, Elsevier BV, p. 110647-110647, 2021/02/25
  • Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, Reiko Watanabe,Tsuyoshi Esaki,Rikiya Ohashi,Masataka Kuroda,Hitoshi Kawashima,Hiroshi Komura,Yayoi Natsume-Kitatani,Kenji Mizuguchi, Journal of Medicinal Chemistry, American Chemical Society (ACS), 2021/02/23
  • Glycan Cluster Shielding and Antibody Epitopes on Lassa Virus Envelop Protein, Suyong Re,Kenji Mizuguchi, The Journal of Physical Chemistry B, American Chemical Society (ACS), Vol. 125, No. 8, p. 2089-2097, 2021/02/19
  • Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres, Taro Koba,Yoshito Takeda,Ryohei Narumi,Takashi Shiromizu,Yosui Nojima,Mari Ito,Muneyoshi Kuroyama,Yu Futami,Takayuki Takimoto,Takanori Matsuki,Ryuya Edahiro,Satoshi Nojima,Yoshitomo Hayama,Kiyoharu Fukushima,Haruhiko Hirata,Shohei Koyama,Kota Iwahori,Izumi Nagatomo,Mayumi Suzuki,Yuya Shirai,Teruaki Murakami,Kaori Nakanishi,Takeshi Nakatani,Yasuhiko Suga,Kotaro Miyake,Takayuki Shiroyama,Hiroshi Kida,Takako Sasaki,Koji Ueda,Kenji Mizuguchi,Jun Adachi,Takeshi Tomonaga,Atsushi Kumanogoh, ERJ Open Research, European Respiratory Society (ERS), Vol. 7, No. 1, p. 00658-2020, 2021/01
  • Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema, Lokesh P. Tripathi,Mari N. Itoh,Yoshito Takeda,Kazuyuki Tsujino,Yasushi Kondo,Atsushi Kumanogoh,Kenji Mizuguchi, Frontiers in Genetics, Frontiers Media SA, Vol. 11, p. 585998-585998, 2020/12/10
  • MANTA, an integrative database and analysis platform that relates microbiome and phenotypic data, Yi-An Chen,Jonguk Park,Yayoi Natsume-Kitatani,Hitoshi Kawashima,Attayeb Mohsen,Koji Hosomi,Kumpei Tanisawa,Harumi Ohno,Kana Konishi,Haruka Murakami,Motohiko Miyachi,Jun Kunisawa,Kenji Mizuguchi, PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12, p. e0243609-e0243609, 2020/12/04
  • Developing a Kinase-Specific Target Selection Method Using a Structure-Based Machine Learning Approach, Arina Afanasyeva,Chioko Nagao,Kenji Mizuguchi, Advances and Applications in Bioinformatics and Chemistry, Informa UK Limited, Vol. Volume 13, p. 27-40, 2020/12
  • Metabolomic analysis of fibrotic mice combined with public RNA-Seq human lung data reveal potential diagnostic biomarker candidates for lung fibrosis., Yosui Nojima,Yoshito Takeda,Yohei Maeda,Takeshi Bamba,Eiichiro Fukusaki,Mari N Itoh,Kenji Mizuguchi,Atsushi Kumanogoh, FEBS open bio, Vol. 10, No. 11, p. 2427-2436, 2020/09/22
  • Panomicon: A web-based environment for interactive, visual analysis of multi-omics data., Rodolfo S Allendes Osorio,Johan T Nyström-Persson,Yosui Nojima,Yuji Kosugi,Kenji Mizuguchi,Yayoi Natsume-Kitatani, Heliyon, Elsevier BV, Vol. 6, No. 8, p. e04618-e04618, 2020/08
  • Update of the GRIP web service., Akira Saito,Daiki Tsuchiya,Seiji Sato,Atsushi Okamoto,Yoichi Murakami,Kenji Mizuguchi,Hiroyuki Toh,Wataru Nemoto, Journal of receptor and signal transduction research, Vol. 40, No. 4, p. 348-356, 2020/08
  • Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs., Tokiko Tabata,Tomoya Yamashita,Koji Hosomi,Jonguk Park,Tomohiro Hayashi,Naofumi Yoshida,Yoshihiro Saito,Koji Fukuzawa,Kana Konishi,Haruka Murakami,Hitoshi Kawashima,Kenji Mizuguchi,Motohiko Miyachi,Jun Kunisawa,Ken-Ichi Hirata, Heart and vessels, Vol. 36, No. 1, p. 105-114, 2020/07/18
  • Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model, Takayuki J. Sanada,Koji Hosomi,Hiroki Shoji,Jonguk Park,Akira Naito,Yumiko Ikubo,Asako Yanagisawa,Takayuki Kobayashi,Hideki Miwa,Rika Suda,Seiichiro Sakao,Kenji Mizuguchi,Jun Kunisawa,Nobuhiro Tanabe,Koichiro Tatsumi, Pulmonary Circulation, SAGE Publications, Vol. 10, No. 3, p. 204589402092914-204589402092914, 2020/07
  • Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein., Makoto Tokunaga,Yoichi Miyamoto,Tatsuya Suzuki,Mayumi Otani,Shinsuke Inuki,Tsuyoshi Esaki,Chioko Nagao,Kenji Mizuguchi,Hiroaki Ohno,Yoshihiro Yoneda,Toru Okamoto,Masahiro Oka,Yoshiharu Matsuura, Virology, Vol. 541, p. 41-51, 2020/02
  • Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains, Miyake K,Sakane A,Tsuchiya Y,Sagawa I,Tomida Y,Kasahara J,Imoto I,Watanabe S,Higo D,Mizuguchi K,Sasaki T, Scientific Reports, Vol. 9, No. 1, p. 12794-12794, 2019/12
  • A prospective compound screening contest identified broader inhibitors for Sirtuin 1, Shuntaro Chiba,Masahito Ohue,Anastasiia Gryniukova,Petro Borysko,Sergey Zozulya,Nobuaki Yasuo,Ryunosuke Yoshino,Kazuyoshi Ikeda,Woong-Hee Shin,Daisuke Kihara,Mitsuo Iwadate,Hideaki Umeyama,Takaaki Ichikawa,Reiji Teramoto,Kun-Yi Hsin,Vipul Gupta,Hiroaki Kitano,Mika Sakamoto,Akiko Higuchi,Nobuaki Miura,Kei Yura,Masahiro Mochizuki,Chandrasekaran Ramakrishnan,A. Mary Thangakani,D. Velmurugan,M. Michael Gromiha,Itsuo Nakane,Nanako Uchida,Hayase Hakariya,Modong Tan,Hironori K. Nakamura,Shogo D. Suzuki,Tomoki Ito,Masahiro Kawatani,Kentaroh Kudoh,Sakurako Takashina,Kazuki Z. Yamamoto,Yoshitaka Moriwaki,Keita Oda,Daisuke Kobayashi,Tatsuya Okuno,Shintaro Minami,George Chikenji,Philip Prathipati,Chioko Nagao,Attayeb Mohsen,Mari Ito,Kenji Mizuguchi,Teruki Honma,Takashi Ishida,Takatsugu Hirokawa,Yutaka Akiyama,Masakazu Sekijima, Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1, 2019/12
  • Development of an in silico prediction system of human renal excretion and clearance from chemical structure information incorporating fraction unbound in plasma as a descriptor, Watanabe R,Ohashi R,Esaki T,Kawashima H,Natsume-Kitatani Y,Nagao C,Mizuguchi K, Scientific Reports, Vol. 9, No. 1, p. 18782-18782, 2019/12
  • Impact of quality trimming on the efficiency of reads joining and diversity analysis of Illumina paired-end reads in the context of QIIME1 and QIIME2 microbiome analysis frameworks, Mohsen A,Park J,Chen YA,Kawashima H,Mizuguchi K, BMC Bioinformatics, Springer Science and Business Media LLC, Vol. 20, No. 1, 2019/12
  • CLINE: a web-tool for the comparison of biological dendrogram structures, Allendes Osorio RS,Tripathi LP,Mizuguchi K, BMC Bioinformatics, Vol. 20, No. 1, 2019/12
  • The TargetMine Data Warehouse: Enhancement and Updates, Chen YA,Tripathi LP,Fujiwara T,Kameyama T,Itoh MN,Mizuguchi K, Frontiers in Genetics, Vol. 10, 2019/10
  • B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant, Michelle Sue Jann Lee,Yayoi Natsume-Kitatani,Burcu Temizoz,Yukiko Fujita,Aki Konishi,Kyoko Matsuda,Yoshikatsu Igari,Toshihiro Tsukui,Kouji Kobiyama,Etsushi Kuroda,Motoyasu Onishi,Thomas Marichal,Wataru Ise,Takeshi Inoue,Tomohiro Kurosaki,Kenji Mizuguchi,Shizuo Akira,Ken J. Ishii,Cevayir Coban, European Journal of Immunology, Vol. 49, No. 9, p. 1433-1440, 2019/09/01
  • Constructing an in silico three-class predictor of human intestinal absorption with Caco-2 permeability and dried-DMSO solubility, Esaki T,Ohashi R,Watanabe R,Natsume-Kitatani Y,Kawashima H,Nagao C,Komura H,Mizuguchi K, Journal of Pharmaceutical Sciences, Vol. 108, No. 11, p. 3630-3639, 2019/07
  • Computational Model To Predict the Fraction of Unbound Drug in the Brain, Tsuyoshi Esaki,Rikiya Ohashi,Reiko Watanabe,Yayoi Natsume-Kitatani,Hitoshi Kawashima,Chioko Nagao,Kenji Mizuguchi, Journal of Chemical Information and Modeling, American Chemical Society ({ACS}), Vol. 59, No. 7, p. 3251-3261, 2019/07
  • Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein, Rikiya Ohashi,Reiko Watanabe,Tsuyoshi Esaki,Tomomi Taniguchi,Nao Torimoto-Katori,Tomoko Watanabe,Yuko Ogasawara,Tsuyoshi Takahashi,Mikiko Tsukimoto,Kenji Mizuguchi, Molecular Pharmaceutics, American Chemical Society ({ACS}), Vol. 16, No. 5, p. 1851-1863, 2019/04
  • High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives, Yuka Kataoka,Hiroto Fujita,Arina Afanaseva,Chioko Nagao,Kenji Mizuguchi,Yuuya Kasahara,Satoshi Obika,Masayasu Kuwahara, Biochemistry, American Chemical Society ({ACS}), Vol. 58, No. 6, p. 493-498, 2019/02
  • Assessing drug target suitability using TargetMine, Yi-An Chen,Erika Yogo,Naoko Kurihara,Tomoshige Ohno,Chihiro Higuchi,Masatomo Rokushima,Kenji Mizuguchi, F1000Research, F1000 ( Faculty of 1000 Ltd), Vol. 8, p. 233-233, 2019/02
  • Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing, Yasuharu Takahashi,Jonguk Park,Koji Hosomi,Tomonori Yamada,Ayaka Kobayashi,Yuji Yamaguchi,Susumu Iketani,Jun Kunisawa,Kenji Mizuguchi,Nobuko Maeda,Tomoko Ohshima, Journal of Oral Biosciences, Elsevier BV, Vol. 61, No. 2, p. 120-128, 2019/01/01
  • Prediction of the secondary structure of short DNA aptamers, Arina Afanasyeva,Chioko Nagao,Kenji Mizuguchi, Biophysics and Physicobiology, Biophysical Society of Japan, Vol. 16, No. 0, p. 287-294, 2019
  • Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance., Esaki T,Watanabe R,Kawashima H,Ohashi R,Natsume-Kitatani Y,Nagao C,Mizuguchi K, Molecular informatics, Vol. 38, No. 1-2, 2018/09
  • Predicting Fraction Unbound in Human Plasma from Chemical Structure: Improved Accuracy in the Low Value Ranges., Watanabe R,Esaki T,Kawashima H,Natsume-Kitatani Y,Nagao C,Ohashi R,Mizuguchi K, Molecular pharmaceutics, Vol. 15, No. 11, p. 5302-5311, 2018/09
  • Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging., Yingji Jin,Yoshito Takeda,Yasushi Kondo,Lokesh P Tripathi,Sujin Kang,Hikari Takeshita,Hanako Kuhara,Yohei Maeda,Masayoshi Higashiguchi,Kotaro Miyake,Osamu Morimura,Taro Koba,Yoshitomo Hayama,Shohei Koyama,Kaori Nakanishi,Takeo Iwasaki,Satoshi Tetsumoto,Kazuyuki Tsujino,Muneyoshi Kuroyama,Kota Iwahori,Haruhiko Hirata,Takayuki Takimoto,Mayumi Suzuki,Izumi Nagatomo,Ken Sugimoto,Yuta Fujii,Hiroshi Kida,Kenji Mizuguchi,Mari Ito,Takashi Kijima,Hiromi Rakugi,Eisuke Mekada,Isao Tachibana,Atsushi Kumanogoh, Scientific reports, Vol. 8, No. 1, p. 5145-5145, 2018/03/23
  • An Antigen-Free, Plasmacytoid Dendritic Cell-Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates., Yuji Masuta,Takuya Yamamoto,Yayoi Natsume-Kitatani,Tomohiro Kanuma,Eiko Moriishi,Kouji Kobiyama,Kenji Mizuguchi,Yasuhiro Yasutomi,Ken J Ishii, Journal of immunology (Baltimore, Md. : 1950), The American Association of Immunologists, Vol. 200, No. 6, p. 2067-2075, 2018/03/15
  • PSOPIA: Toward more reliable protein-protein interaction prediction from sequence information, Yoichi Murakami,Kenji Mizuguchi, ICIIBMS 2017 - 2nd International Conference on Intelligent Informatics and Biomedical Sciences, Institute of Electrical and Electronics Engineers Inc., Vol. 2018-, p. 255-261, 2018/02/02
  • Essential role of CARD14 in murine experimental psoriasis, Mayuri Tanaka,Kouji Kobiyama,Tetsuya Honda,Kozue Uchio-Yamada,Yayoi Natsume-Kitatani,Kenji Mizuguchi,Kenji Kabashima,Ken J. Ishii, Journal of Immunology, American Association of Immunologists, Vol. 200, No. 1, p. 71-81, 2018/01/01
  • Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism, Shandar Ahmad,Philip Prathipati,Lokesh P. Tripathi,Yi-An Chen,Ajay Arya,Yoichi Murakami,Kenji Mizuguchi, Nucleic Acids Research, Oxford University Press, Vol. 46, No. 1, p. 54-70, 2018
  • Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data, Edward Wijaya,Yoshinobu Igarashi,Noriyuki Nakatsu,Yasunari Haseda,Joel Billaud,Yi-An Chen,Kenji Mizuguchi,Hiroshi Yamada,Ken Ishii,Taiki Aoshi, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/10
  • Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity., Koji Hosomi,Harumi Ohno,Haruka Murakami,Yayoi Natsume-Kitatani,Kumpei Tanisawa,Soichiro Hirata,Hidehiko Suzuki,Takahiro Nagatake,Tomomi Nishino,Kenji Mizuguchi,Motohiko Miyachi,Jun Kunisawa, Scientific reports, Vol. 7, No. 1, p. 4339-4339, 2017/06/28
  • Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences, Munazah Andrabi,Andrew Paul Hutchins,Diego Miranda-Saavedra,Hidetoshi Kono,Ruth Nussinov,Kenji Mizuguchi,Shandar Ahmad, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/06
  • Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates, Johan Nystroem-Persson,Yayoi Natsume-Kitatani,Yoshinobu Igarashi,Daisuke Satoh,Kenji Mizuguchi, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/05
  • A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells, Tetsuro Yoshimaru,Masaya Ono,Yoshimi Bando,Yi-An Chen,Kenji Mizuguchi,Hiroshi Shima,Masato Komatsu,Issei Imoto,Keisuke Izumi,Junko Honda,Yasuo Miyoshi,Mitsunori Sasa,Toyomasa Katagiri, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 8, 2017/05
  • Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody, Yoshimasa Hamano,Hiroshi Kida,Shoichi Ihara,Akihiro Murakami,Masahiro Yanagawa,Ken Ueda,Osamu Honda,Lokesh P. Tripathi,Toru Arai,Masaki Hirose,Toshimitsu Hamasaki,Yukihiro Yano,Tetsuya Kimura,Yasuhiro Kato,Hyota Takamatsu,Tomoyuki Otsuka,Toshiyuki Minami,Haruhiko Hirata,Koji Inoue,Izumi Nagatomo,Yoshito Takeda,Masahide Mori,Hiroyoshi Nishikawa,Kenji Mizuguchi,Takashi Kijima,Masanori Kitaichi,Noriyuki Tomiyama,Yoshikazu Inoue,Atsushi Kumanogoh, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, 2017/02
  • Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine., Satoshi Takashima,Yoshihiro Oka,Fumihiro Fujiki,Soyoko Morimoto,Hiroko Nakajima,Yoshiki Nakae,Jun Nakata,Sumiyuki Nishida,Naoki Hosen,Naoya Tatsumi,Kenji Mizuguchi,Naoya Hashimoto,Yusuke Oji,Akihiro Tsuboi,Atsushi Kumanogoh,Haruo Sugiyama, Future science OA, Vol. 2, No. 4, 2016/12
  • Conformational plasticity of JRAB/MICAL-L2 provides "law and order" in collective cell migration, Ayuko Sakane,Shin Yoshizawa,Masaomi Nishimura,Yuko Tsuchiya,Natsuki Matsushita,Kazuhisa Miyake,Kazuki Horikawa,Issei Imoto,Chiharu Mizuguchi,Hiroyuki Saito,Takato Ueno,Sachi Matsushita,Hisashi Haga,Shinji Deguchi,Kenji Mizuguchi,Hideo Yokota,Takuya Sasaki, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 27, No. 20, p. 3095-3108, 2016/10
  • Improved pose and affinity predictions using different protocols tailored on the basis of data availability, Philip Prathipati,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, SPRINGER, Vol. 30, No. 9, p. 817-828, 2016/09
  • Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1, Yuko Tsuchiya,Nao Jounai,Fumihiko Takeshita,Ken J. Ishii,Kenji Mizuguchi, EBIOMEDICINE, ELSEVIER SCIENCE BV, Vol. 9, p. 87-96, 2016/07
  • Integration of Ligand and Structure Based Approaches for CSAR-2014, Philip Prathipati,Kenji Mizuguchi, JOURNAL OF CHEMICAL INFORMATION AND MODELING, AMER CHEMICAL SOC, Vol. 56, No. 6, p. 974-987, 2016/06
  • The diversity of H3 loops determines the antigen-binding tendencies of antibody CDR loops, Yuko Tsuchiya,Kenji Mizuguchi, PROTEIN SCIENCE, WILEY-BLACKWELL, Vol. 25, No. 4, p. 815-825, 2016/04
  • An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework, Yi-An Chen,Lokesh P. Tripathi,Kenji Mizuguchi, DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, OXFORD UNIV PRESS, Vol. 2016, 2016/03
  • Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence, Akira Tsujii,Yoichi Miyamoto,Tetsuji Moriyama,Yuko Tsuchiya,Chikashi Obuse,Kenji Mizuguchi,Masahiro Oka,Yoshihiro Yoneda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 49, p. 29375-29388, 2015/12
  • Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis, Juneyoung Lee,Eun Jeong Park,Yoshikazu Yuki,Shandar Ahmad,Kenji Mizuguchi,Ken J. Ishii,Motomu Shimaoka,Hiroshi Kiyono, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 5, 2015/12
  • Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target, Shuntaro Chiba,Kazuyoshi Ikeda,Takashi Ishida,M. Michael Gromiha,Y-h. Taguchi,Mitsuo Iwadate,Hideaki Umeyama,Kun-Yi Hsin,Hiroaki Kitano,Kazuki Yamamoto,Nobuyoshi Sugaya,Koya Kato,Tatsuya Okuno,George Chikenji,Masahiro Mochizuki,Nobuaki Yasuo,Ryunosuke Yoshino,Keisuke Yanagisawa,Tomohiro Ban,Reiji Teramoto,Chandrasekaran Ramakrishnan,A. Mary Thangakani,D. Velmurugan,Philip Prathipati,Junichi Ito,Yuko Tsuchiya,Kenji Mizuguchi,Teruki Honma,Takatsugu Hirokawa,Yutaka Akiyama,Masakazu Sekijima, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 5, 2015/11
  • Two distinct effector memory cell populations of WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients, Yoshiki Nakae,Yoshihiro Oka,Fumihiro Fujiki,Soyoko Morimoto,Toshio Kamiya,Satoshi Takashima,Jun Nakata,Sumiyuki Nishida,Hiroko Nakajima,Naoki Hosen,Akihiro Tsuboi,Taiichi Kyo,Yusuke Oji,Kenji Mizuguchi,Atsushi Kumanogoh,Haruo Sugiyama, CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, Vol. 64, No. 7, p. 791-804, 2015/07
  • BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells, Nam-Hee Kim,Tetsuro Yoshimaru,Yi-An Chen,Taisuke Matsuo,Masato Komatsu,Yasuo Miyoshi,Eiji Tanaka,Mitsunori Sasa,Kenji Mizuguchi,Toyomasa Katagiri, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 6, 2015/06
  • Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing (10, e0115369, 2015), Luiz Miguel Camargo,Xiaohua Douglas Zhang,Patrick Loerch,Ramon Miguel Caceres,Shane D. Marine,Paolo Uva,Marc Ferrer,Emanuele de Rinaldis,David J. Stone,John Majercak,William J. Ray,Chen Yi-An,Mark S. Shearman,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 6, 2015/06
  • Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing, Luiz Miguel Camargo,Xiaohua Douglas Zhang,Patrick Loerch,Ramon Miguel Caceres,Shane D. Marine,Paolo Uva,Marc Ferrer,Emanuele de Rinaldis,David J. Stone,John Majercak,William J. Ray,Chen Yi-An,Mark S. Shearman,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 2, 2015/02
  • PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs, Jun-ichi Ito,Kazuyoshi Ikeda,Kazunori Yamada,Kenji Mizuguchi,Kentaro Tomii, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 43, No. D1, p. D392-D398, 2015/01
  • Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line, Ayako Kumagai,Akira Fujita,Tomoki Yokoyama,Yuki Nonobe,Yasuhiro Hasaba,Tsutomu Sasaki,Yumi Itoh,Minako Koura,Osamu Suzuki,Shigeki Adachi,Haruko Ryo,Arihiro Kohara,Lokesh P. Tripathi,Masato Sanosaka,Toshiki Fukushima,Hiroyuki Takahashi,Kazuo Kitagawa,Yasuo Nagaoka,Hidehisa Kawahara,Kenji Mizuguchi,Taisei Nomura,Junichiro Matsuda,Toshihide Tabata,Hiroshi Takemori, Genes, MDPI AG, Vol. 5, No. 4, p. 1095-1114, 2014/12
  • Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein, Hiroshi Yamada,Chioko Nagao,Ahmad M. Haredy,Yasuko Mori,Kenji Mizuguchi,Koichi Yamanishi,Shigefumi Okamoto, ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV, Vol. 111, p. 69-77, 2014/11
  • High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations, Hiroki Shirai,Kazuyoshi Ikeda,Kazuo Yamashita,Yuko Tsuchiya,Jamica Sarmiento,Shide Liang,Tatsuaki Morokata,Kenji Mizuguchi,Junichi Higo,Daron M. Standley,Haruki Nakamura, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-BLACKWELL, Vol. 82, No. 8, p. 1624-1635, 2014/08
  • Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) is predicted to interact with its partner through an ARM-type -helical structure, Yi-An Chen,Yoichi Murakami,Shandar Ahmad,Tetsuro Yoshimaru,Toyomasa Katagiri,Kenji Mizuguchi, BMC Research Notes, BioMed Central Ltd., Vol. 7, No. 1, 2014/07/06
  • Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators, Yoichi Murakami,Kenji Mizuguchi, BMC BIOINFORMATICS, BIOMED CENTRAL LTD, Vol. 15, No. 1, 2014/06
  • Integrated Pathway Clusters with Coherent Biological Themes for Target Prioritisation, Yi-An Chen,Lokesh P. Tripathi,Benoit H. Dessailly,Johan Nystroem-Persson,Shandar Ahmad,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 9, No. 6, 2014/06
  • Crystal structure of FtsA from Staphylococcus aureus, Junso Fujita,Yoko Maeda,Chioko Nagao,Yuko Tsuchiya,Yuma Miyazaki,Mika Hirose,Eiichi Mizohata,Yoshimi Matsumoto,Tsuyoshi Inoue,Kenji Mizuguchi,Hiroyoshi Matsumura, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 588, No. 10, p. 1879-1885, 2014/05
  • Conformational changes in DNA-binding proteins: Relationships with precomplex features and contributions to specificity and stability, Munazah Andrabi,Kenji Mizuguchi,Shandar Ahmad, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-BLACKWELL, Vol. 82, No. 5, p. 841-857, 2014/05
  • Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome, Naoki Takemura,Takumi Kawasaki,Jun Kunisawa,Shintaro Sato,Aayam Lamichhane,Kouji Kobiyama,Taiki Aoshi,Junichi Ito,Kenji Mizuguchi,Thangaraj Karuppuchamy,Kouta Matsunaga,Shoichiro Miyatake,Nobuko Mori,Tohru Tsujimura,Takashi Satoh,Yutaro Kumagai,Taro Kawai,Daron M. Standley,Ken J. Ishii,Hiroshi Kiyono,Shizuo Akira,Satoshi Uematsu, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 5, 2014/03
  • Prediction of Detailed Enzyme Functions and Identification of Specificity Determining Residues by Random Forests, Chioko Nagao,Nozomi Nagano,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 9, No. 1, 2014/01
  • Toxygates: interactive toxicity analysis on a hybrid microarray and linked data platform, Johan Nystroem-Persson,Yoshinobu Igarashi,Maori Ito,Mizuki Morita,Noriyuki Nakatsu,Hiroshi Yamada,Kenji Mizuguchi, BIOINFORMATICS, OXFORD UNIV PRESS, Vol. 29, No. 23, p. 3080-3086, 2013/12
  • Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus, Junso Fujita,Yuma Miyazaki,Mika Hirose,Chioko Nagao,Eiichi Mizohata,Yoshimi Matsumoto,Kenji Mizuguchi,Tsuyoshi Inoue,Hiroyoshi Matsumura, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, WILEY-BLACKWELL, Vol. 69, No. 8, p. 895-898, 2013/08
  • Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid A gene promoter, Prabha Tiwari,Lokesh P. Tripathi,Teppei Nishikawa-Matsumura,Shandar Ahmad,Soken-Nakazawa J. Song,Tomoyasu Isobe,Kenji Mizuguchi,Kazuyuki Yoshizaki, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ELSEVIER SCIENCE BV, Vol. 1830, No. 6, p. 3650-3655, 2013/06
  • Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach, Lokesh P. Tripathi,Hiroto Kambara,Yi-An Chen,Yorihiro Nishimura,Kohji Moriishi,Toru Okamoto,Eiji Morita,Takayuki Abe,Yoshio Mori,Yoshiharu Matsuura,Kenji Mizuguchi, JOURNAL OF PROTEOME RESEARCH, AMER CHEMICAL SOC, Vol. 12, No. 6, p. 2537-2551, 2013/06
  • Functional site plasticity in domain superfamilies, Benoit H. Dessailly,Natalie L. Dawson,Kenji Mizuguchi,Christine A. Orengo, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, ELSEVIER SCIENCE BV, Vol. 1834, No. 5, p. 874-889, 2013/05
  • The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant, Choon Kit Tang,Taiki Aoshi,Nao Jounai,Junichi Ito,Keiichi Ohata,Kouji Kobiyama,Benoit H. Dessailly,Etsushi Kuroda,Shizuo Akira,Kenji Mizuguchi,Cevayir Coban,Ken J. Ishii, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 8, No. 3, 2013/03
  • Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells., Tetsuro Yoshimaru,Masato Komatsu,Taisuke Matsuo,Yi-An Chen,Yoichi Murakami,Kenji Mizuguchi,Eiichi Mizohata,Tsuyoshi Inoue,Miki Akiyama,Rui Yamaguchi,Seiya Imoto,Satoru Miyano,Yasuo Miyoshi,Mitsunori Sasa,Yusuke Nakamura,Toyomasa Katagiri, Nature communications, Vol. 4, p. 2443-2443, 2013
  • Computational design, construction, and characterization of a set of specificity determining residues in protein-protein interactions, Chioko Nagao,Nozomi Izako,Shinji Soga,Samia Haseeb Khan,Shigeki Kawabata,Hiroki Shirai,Kenji Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-BLACKWELL, Vol. 80, No. 10, p. 2426-2436, 2012/10
  • Proteomic Analysis of Hepatitis C Virus (HCV) Core Protein Transfection and Host Regulator PA28 gamma Knockout in HCV Pathogenesis: A Network-Based Study, Lokesh P. Tripathi,Hiroto Kambara,Kohji Moriishi,Eiji Morita,Takayuki Abe,Yoshio Mori,Yi-An Chen,Yoshiharu Matsuura,Kenji Mizuguchi, JOURNAL OF PROTEOME RESEARCH, AMER CHEMICAL SOC, Vol. 11, No. 7, p. 3664-3679, 2012/07
  • Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes, Tim R. Blower,Francesca L. Short,Feng Rao,Kenji Mizuguchi,Xue Y. Pei,Peter C. Fineran,Ben F. Luisi,George P. C. Salmond, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 40, No. 13, p. 6158-6173, 2012/07
  • Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis, Shoichi Ihara,Hiroshi Kida,Hisashi Arase,Lokesh P. Tripathi,Yi-An Chen,Tetsuya Kimura,Mitsuhiro Yoshida,Yozo Kashiwa,Haruhiko Hirata,Reiko Fukamizu,Ruriko Inoue,Kana Hasegawa,Sho Goya,Ryo Takahashi,Toshiyuki Minami,Kazuyuki Tsujino,Mayumi Suzuki,Satoshi Kohmo,Koji Inoue,Izumi Nagatomo,Yoshito Takeda,Takashi Kijima,Kenji Mizuguchi,Isao Tachibana,Atsushi Kumanogoh, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, No. 12, p. 2990-2999, 2012/06
  • Sagace: A web-based search engine for biomedical databases in Japan, Mizuki Morita,Yoshinobu Igarashi,Maori Ito,Yi-An Chen,Chioko Nagao,Yuki Sakaguchi,Ryuichi Sakate,Tohru Masui,Kenji Mizuguchi, BMC Research Notes, Vol. 5, 2012
  • Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data, Mizuki Morita,AVSK M. Katta,Shandar Ahmad,Takaharu Mori,Yuji Sugita,Kenji Mizuguchi, BMC Biophysics, Vol. 4, No. 1, 2011/12/14
  • Partner-Aware Prediction of Interacting Residues in Protein-Protein Complexes from Sequence Data, Shandar Ahmad,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 12, 2011/12
  • Prediction of dinucleotide-specific RNA-binding sites in proteins, Michael Fernandez,Yutaro Kumagai,Daron M. Standley,Akinori Sarai,Kenji Mizuguchi,Shandar Ahmad, BMC BIOINFORMATICS, BIOMED CENTRAL LTD, Vol. 12, No. S-13, 2011/11
  • Using Knowledge of Protein Structural Constraints to Predict the Evolution of HIV-1, Simon G. Williams,Rachit Madan,Matthew G. S. Norris,John Archer,Kenji Mizuguchi,David L. Robertson,Simon C. Lovell, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 410, No. 5, p. 1023-1034, 2011/07
  • Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity, Ute I. Schwarz,Henriette E. Meyer Zu Schwabedissen,Rommel G. Tirona,Atsuko Suzuki,Brenda F. Leake,Younes Mokrab,Kenji Mizuguchi,Richard H. Ho,Richard B. Kim, PHARMACOGENETICS AND GENOMICS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 21, No. 3, p. 103-114, 2011/03
  • TargetMine, an Integrated Data Warehouse for Candidate Gene Prioritisation and Target Discovery, Yi-An Chen,Lokesh P. Tripathi,Kenji Mizuguchi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 3, 2011/03
  • A structural dissection of amino acid substitutions in helical transmembrane proteins, Younes Mokrab,Tim J. Stevens,Kenji Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-BLACKWELL, Vol. 78, No. 14, p. 2895-2907, 2010/11
  • Detecting subtle functional differences in ketopantoate reductase and related enzymes using a rule-based approach with sequence-structure homology recognition scores, Sukanta Mondal,Chioko Nagao,Kenji Mizuguchi, PROTEIN ENGINEERING DESIGN & SELECTION, OXFORD UNIV PRESS, Vol. 23, No. 11, p. 859-869, 2010/11
  • Integrated prediction of one-dimensional structural features and their relationships with conformational flexibility in helical membrane proteins, Shandar Ahmad,Yumlembam Hemajit Singh,Yogesh Paudel,Takaharu Mori,Yuji Sugita,Kenji Mizuguchi, BMC BIOINFORMATICS, BIOMED CENTRAL LTD, Vol. 11, 2010/10
  • On nucleotide solvent accessibility in RNA structure, Yumlembam H. Singh,Munazah Andrabi,Bratati Kahali,Tapash Chandra Ghosh,Kenji Mizuguchi,Alex V. Kochetov,Shandar Ahmad, GENE, ELSEVIER SCIENCE BV, Vol. 463, No. 1-2, p. 41-48, 2010/09
  • Relationships between functional subclasses and information contained in active-site and ligand-binding residues in diverse superfamilies, Chioko Nagao,Nozomi Nagano,Kenji Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY, Vol. 78, No. 10, p. 2369-2384, 2010/08
  • CCRXP: exploring clusters of conserved residues in protein structures, Shandar Ahmad,Ozlem Keskin,Kenji Mizuguchi,Akinori Sarai,Ruth Nussinov, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 38, No. SUPPL. 2, p. W398-W401, 2010/07
  • Applying the Naïve Bayes classifier with kernel density estimation to the prediction of protein–protein interaction sites, Yoichi Murakami,Kenji Mizuguchi, Bioinformatics, Oxford University Press (OUP), Vol. 26, No. 15, p. 1841-1848, 2010/06/06
  • Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, BIOMATERIALS, ELSEVIER SCI LTD, Vol. 31, No. 7, p. 1935-1943, 2010/03
  • Network based analysis of hepatitis C virus Core and NS4B protein interactions, Lokesh P. Tripathi,Chikako Kataoka,Shuhei Taguwa,Kohji Moriishi,Yoshio Mori,Yoshiharu Matsuura,Kenji Mizuguchi, MOLECULAR BIOSYSTEMS, ROYAL SOC CHEMISTRY, Vol. 6, No. 12, p. 2539-2553, 2010
  • Structural insights into the enzyme mechanism of a new family of d-2-hydroxyacid dehydrogenases, a close homolog of 2-ketopantoate reductase., Mondal S,Mizuguchi K, Genome informatics. International Conference on Genome Informatics, Vol. 23, No. 1, p. 98-105, 2009/10/01
  • Prediction of mono- and di-nucleotide-specific DNA-binding sites in proteins using neural networks, Munazah Andrabi,Kenji Mizuguchi,Akinori Sarai,Shandar Ahmad, BMC STRUCTURAL BIOLOGY, BIOMED CENTRAL LTD, Vol. 9, 2009/05
  • Prediction of mono- and di-nucleotide-specific DNA-binding sites in proteins using neural networks, Munazah Andrabi,Kenji Mizuguchi,Akinori Sarai,Shandar Ahmad, BMC Structural Biology, Vol. 9, 2009
  • Molecular Basis for SUMOylation-dependent Regulation of DNA Binding Activity of Heat Shock Factor 2, Yukihiro Tateishi,Mariko Ariyoshi,Ryuji Igarashi,Hideyuki Hara,Kenji Mizuguchi,Azusa Seto,Akira Nakai,Tetsuro Kokubo,Hidehito Tochio,Masahiro Shirakawa, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 284, No. 4, p. 2435-2447, 2009/01
  • Lipophobicity and the residue environments of the transmembrane alpha-helical bundle, Younes Mokrab,Thn J. Stevens,Kenji Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-LISS, Vol. 74, No. 1, p. 32-49, 2009/01
  • Docking of cytochrome c(6) and plastocyanin to the aa(3)-type cytochrome c oxidase in the cyanobacterium Phormidium laminosum, Sarah E. Hart,Christopher J. Howe,Kenji Mizuguchi,Juan Fernandez-Recio, PROTEIN ENGINEERING DESIGN & SELECTION, OXFORD UNIV PRESS, Vol. 21, No. 12, p. 689-698, 2008/12
  • Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation, Bangfu Zhu,Jenny A. Pennack,Peter McQuilton,Manuel G. Forero,Kenji Mizuguchi,Ben Sutcliffe,Chun-Jing Gu,Janine C. Fenton,Alicia Hidalgo, PLOS BIOLOGY, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 11, p. 2476-2495, 2008/11
  • A phylogenomic profile of hemerythrins, the nonheme diiron binding respiratory proteins, Xavier Bailly,Stefano Vanin,Christine Chabasse,Kenji Mizuguchi,Serge N. Vinogradov, BMC EVOLUTIONARY BIOLOGY, BIOMED CENTRAL LTD, Vol. 8, No. 1, 2008/09
  • Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor, Younes Mokrab,Vassiliy N. Bavro,Kenji Mizuguchi,N. P. Todorov,Ian L. Martin,Susan M. J. Dunn,S. L. Chan,P. -L. Chau, JOURNAL OF MOLECULAR GRAPHICS & MODELLING, ELSEVIER SCIENCE INC, Vol. 26, No. 4, p. 760-774, 2007/11
  • A model of globin evolution, Serge N. Vinogradov,David Hoogewijs,Xavier Bailly,Kenji Mizuguchi,Sylvia Dewilde,Luc Moens,Jacques R. Vanfleteren, GENE, ELSEVIER SCIENCE BV, Vol. 398, No. 1-2, p. 132-142, 2007/08
  • Environment specific substitution tables for thermophilic proteins, K. Mizuguchi,M. Sele,M. V. Cubellis, BMC BIOINFORMATICS, BIOMED CENTRAL LTD, Vol. 8, 2007
  • Disrupted in schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia, L. M. Camargo,V. Collura,J-C Rain,K. Mizuguchi,H. Hermjakob,S. Kerrien,T. P. Bonnert,P. J. Whiting,N. J. Brandon, MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP, Vol. 12, No. 1, p. 74-86, 2007/01
  • FlyMine: an integrated database for Drosophila and Anopheles genomics, Rachel Lyne,Richard Smith,Kim Rutherford,Matthew Wakeling,Andrew Varley,Francois Guillier,Hilde Janssens,Wenyan Ji,Peter Mclaren,Philip North,Debashis Rana,Tom Riley,Julie Sullivan,Xavier Watkins,Mark Woodbridge,Kathryn Lilley,Steve Russell,Michael Ashburner,Kenji Mizuguchi,Gos Micklem, GENOME BIOLOGY, BIOMED CENTRAL LTD, Vol. 8, No. 7, 2007
  • The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97, Kumiko Shiozawa,Natsuko Goda,Toshiyuki Shimizu,Kenji Mizuguchi,Naomi Kondo,Nobuyuki Shimozawa,Masahiro Shirakawa,Hidekazu Hiroaki, FEBS JOURNAL, BLACKWELL PUBLISHING, Vol. 273, No. 21, p. 4959-4971, 2006/11
  • The guanidino-group modifying enzymes: Structural basis for their diversity and commonality, Hiroki Shirai,Younes Mokrab,Kenji Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-LISS, Vol. 64, No. 4, p. 1010-1023, 2006/09
  • A novel mechanism of allosteric regulation of archaeal phosphoenolpyruvate carboxylase: a combined approach to structure-based alignment and model assessment, Hiroyoshi Matsumura,Katsura Izui,Kenji Mizuguchi, PROTEIN ENGINEERING DESIGN & SELECTION, OXFORD UNIV PRESS, Vol. 19, No. 9, p. 409-419, 2006/09
  • Organic anion transporting polypeptides of the OATP/SLCO superfamily: Identification of new members in nonmammalian species, comparative modeling and a potential transport mode, F Meier-Abt,Y Mokrab,K Mizuguchi, JOURNAL OF MEMBRANE BIOLOGY, SPRINGER, Vol. 208, No. 3, p. 213-227, 2006/04/20
  • Functional restraints on the patterns of amino acid substitutions: Application to sequence-structure homology recognition, Chelliah, V,T Blundell,K Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, WILEY-LISS, Vol. 61, No. 4, p. 722-731, 2005/12
  • Amino-acid substitutions in membrane proteins: Applications to homology recognition and comparative modelling, Younes Mokrab,Kenji Mizuguchi, BMC BIOINFORMATICS, BIOMED CENTRAL LTD, Vol. 6, No. S-3, 2005/09
  • A model of a transmembrane drug-efflux pump from Gram-negative bacteria, J Fernandez-Recio,F Walas,L Federici,JV Pratap,VN Bavro,RN Miguel,K Mizuguchi,B Luisi, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 578, No. 1-2, p. 5-9, 2004/12
  • Distinct protein interfaces in transmembrane domains suggest an in vivo folding model, TJ Stevens,K Mizuguchi,IT Arkin, PROTEIN SCIENCE, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 13, No. 11, p. 3028-3037, 2004/11
  • HOMSTRAD: recent developments of the Homologous Protein Structure Alignment Database, LA Stebbings,K Mizuguchi, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 32, No. Database-Issue, p. D203-D207, 2004/01
  • Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism, H Shirai,K Mizuguchi, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 555, No. 3, p. 505-510, 2003/12
  • The export of coat protein from enteroaggregative Escherichia coli by a specific ATP-binding cassette transporter system, J Nishi,J Sheikh,K Mizuguchi,B Luisi,Burland, V,A Boutin,DJ Rose,FR Blattner,JP Nataro, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 278, No. 46, p. 45680-45689, 2003/11
  • Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein, M Witty,C Sanz,A Shah,JG Grossmann,K Mizuguchi,RN Perham,B Luisi, EMBO JOURNAL, OXFORD UNIV PRESS, Vol. 21, No. 16, p. 4207-4218, 2002/08
  • The SWIB and the MDM2 domains are homologous and share a common fold, R Bennett-Lovsey,SE Hart,H Shirai,K Mizuguchi, BIOINFORMATICS, OXFORD UNIV PRESS, Vol. 18, No. 4, p. 626-630, 2002/04
  • A family of proteins related to Spatzle, the toll receptor ligand, are encoded in the Drosophila genome, JS Parker,K Mizuguchi,NJ Gay, PROTEINS-STRUCTURE FUNCTION AND GENETICS, WILEY-LISS, Vol. 45, No. 1, p. 71-80, 2001/10
  • HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families, PIW de Bakker,A Bateman,DF Burke,RN Miguel,K Mizuguchi,J Shi,H Shirai,TL Blundell, BIOINFORMATICS, OXFORD UNIV PRESS, Vol. 17, No. 8, p. 748-749, 2001/08
  • A novel superfamily of enzymes that catalyze the modification of guanidino groups, H Shirai,TL Blundell,K Mizuguchi, TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER SCIENCE LONDON, Vol. 26, No. 8, p. 465-468, 2001/08
  • FUGUE: Sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties, JY Shi,TL Blundell,K Mizuguchi, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD, Vol. 310, No. 1, p. 243-257, 2001/06
  • Sequence-structure homology recognition by iterative alignment refinement and comparative modeling, MG Williams,H Shirai,J Shi,HG Nagendra,J Mueller,K Mizuguchi,RN Miguel,SC Lovell,CA Innis,CM Deane,L Chen,N Campillo,DF Burke,TL Blundell,PIW de Bakker, PROTEINS-STRUCTURE FUNCTION AND GENETICS, WILEY-LISS, Vol. 45, No. SUPPL. 5, p. 92-97, 2001
  • Analysis of conservation and substitutions of secondary structure elements within protein superfamilies, K Mizuguchi,TL Blundell, BIOINFORMATICS, OXFORD UNIV PRESS, Vol. 16, No. 12, p. 1111-1119, 2000/12
  • beta 3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics, K Morgan,EB Stevens,B Shah,PJ Cox,AK Dixon,K Lee,RD Pinnock,J Hughes,PJ Richardson,K Mizuguchi,AP Jackson, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 97, No. 5, p. 2308-2313, 2000/02
  • Characterisation of the gene for Drosophila amphiphysin, A Razzaq,Y Su,JE Mehren,K Mizuguchi,AP Jackson,NJ Gay,CJ O'Kane, GENE, ELSEVIER SCIENCE BV, Vol. 241, No. 1, p. 167-174, 2000/01
  • A six-stranded double-psi beta barrel is shared by several protein superfamilies, RM Castillo,K Mizuguchi,Dhanaraj, V,A Albert,TL Blundell,AG Murzin, STRUCTURE WITH FOLDING & DESIGN, CURRENT BIOLOGY LTD, Vol. 7, No. 2, p. 227-236, 1999/02
  • An iterative structure-assisted approach to sequence alignment and comparative modeling, DF Burke,CM Deane,HA Nagarajaram,N Campillo,M Martin-Martinez,J Mendes,F Molina,J Perry,BVB Reddy,CM Soares,RE Steward,M Williams,MA Carrondo,TL Blundell,K Mizuguchi, PROTEINS-STRUCTURE FUNCTION AND GENETICS, WILEY-LISS, Vol. 37, p. 55-60, 1999
  • A third fibronectin type III domain in the extracellular region of the insulin receptor family, C Marino-Buslje,K Mizuguchi,K Siddle,TL Blundell, FEBS LETTERS, ELSEVIER SCIENCE BV, Vol. 441, No. 2, p. 331-336, 1998/12
  • Protein three-dimensional structural databases: Domains, structurally aligned homologues and superfamilies, R Sowdhamini,DF Burke,C Deane,JF Huang,K Mizuguchi,HA Nagarajaram,JP Overington,N Srinivasan,RE Steward,TL Blundell, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, MUNKSGAARD INT PUBL LTD, Vol. 54, p. 1168-1177, 1998/11
  • CAMPASS: a database of structurally aligned protein superfamilies, R Sowdhamini,DF Burke,JF Huang,K Mizuguchi,HA Nagarajaram,N Srinivasan,RE Steward,TL Blundell, STRUCTURE WITH FOLDING & DESIGN, CURRENT BIOLOGY LTD, Vol. 6, No. 9, p. 1087-1094, 1998/09
  • Getting knotted: a model for the structure and activation of Spatzle, K Mizuguchi,JS Parker,TL Blundell,NJ Gay, TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER SCI LTD, Vol. 23, No. 7, p. 239-242, 1998/07
  • HOMSTRAD: A database of protein structure alignments for homologous families, Kenji Mizuguchi,Charlotte M. Deane,Tom L. Blundell, John,P. Overington, Protein Science, Vol. 7, p. 2469-2471, 1998/01/01
  • Erratum: Getting knotted: A model for the structure and activation of Spatzle (TIBS 23 (239-242)), K. Mizuguchi, Trends in Biochemical Sciences, Vol. 23, No. 9, p. 361-361, 1998/01/01
  • JOY: protein sequence-structure representation and analysis, K Mizuguchi,CM Deane,TL Blundell,MS Johnson,JP Overingon, BIOINFORMATICS, OXFORD UNIV PRESS, Vol. 14, No. 7, p. 617-623, 1998
  • Crystal structure of glutathione synthetase at optimal pH: Domain architecture and structural similarity with other proteins, K Matsuda,K Mizuguchi,T Nishioka,H Kato,N Go,J Oda, PROTEIN ENGINEERING, OXFORD UNIV PRESS, Vol. 9, No. 12, p. 1083-1092, 1996/12
  • Comparison of spatial arrangements of secondary structural elements in proteins, K. Mizuguchi,N. Go, Protein Engineering, Vol. 8, No. 4, p. 353-362, 1995
  • Collective motions in proteins investigated by X‐ray diffuse scattering, K MIZUGUCHI,A KIDERA,N GO, PROTEINS-STRUCTURE FUNCTION AND GENETICS, WILEY-LISS, Vol. 18, No. 1, p. 34-48, 1994/01

Misc.

  • The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery, Hiroshi Komura,Reiko Watanabe,Kenji Mizuguchi, Pharmaceutics, MDPI AG, Vol. 15, No. 11, p. 2619-2619, 2023/11/12
  • ナノ粒子をより安全に 設計するための新手法 ──ナノ粒子の安全性に革命を： AI が拓く未来, MARTIN,渡邉怜子,水口賢司, 化学, Vol. 78, No. 11, p. 27-30, 2023/11
  • 「新薬創出を加速する人工知能の開発」 IPF患者臨床データから創薬標的への知識処理, 伊藤 眞里,武田 吉人,黒田 正孝,荒牧 英治,黒橋 禎夫,武田 理宏,梁川 雅弘,富山 憲幸,松村 泰志,足立 淳,水口 賢司,上田 修功,熊ノ郷 淳,夏目 やよい, 日本呼吸器学会誌, (一社)日本呼吸器学会, Vol. 12, No. 増刊, p. 293-293, 2023/03
  • Recent developments of sequence-based prediction of protein-protein interactions., Yoichi Murakami,Kenji Mizuguchi, Biophysical reviews, p. 1-19, 2022/12/24
  • 「新薬創出を加速する人工知能の開発」 特発性肺線維症臨床情報収集と創薬標的探索手法の構築, 伊藤 眞里,黒田 正孝,夏目 やよい,武田 吉人,武田 理宏,松村 泰志,黒橋 禎夫,荒牧 英治,北村 英也,小倉 高志,足立 淳,鎌田 英世,深川 明子,樋口 千洋,水口 賢司,熊ノ郷 淳,上田 修功, 医療情報学連合大会論文集, (一社)日本医療情報学会, Vol. 42回, p. 1067-1069, 2022/11
  • 臨床データの匿名加工情報作成に向けた検討 新薬創出を加速する人工知能の開発におけるデータ利用促進に向けて, 黒田 正孝,伊藤 眞里,夏目 やよい,鎌田 英世,深川 明子,武田 吉人,武田 理宏,松村 泰志,北村 英也,丹羽 崇,岩澤 多恵,高橋 陽子,荒牧 英治,黒橋 禎夫,水口 賢司,小倉 高志,熊ノ郷 淳, 医療情報学連合大会論文集, (一社)日本医療情報学会, Vol. 42回, p. 1070-1072, 2022/11
  • AIサイエンスによるがん研究の臨床応用と創薬にむけて 新薬創出を加速させるAIの開発(Developing AI to accelerate drug target discovery), 夏目 やよい,伊藤 眞里,武田 吉人,足立 淳,黒橋 禎夫,荒牧 英治,武田 理宏,水口 賢司,熊ノ郷 淳,上田 修功, 日本癌学会総会記事, (一社)日本癌学会, Vol. 81回, p. S1-2, 2022/09
  • Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters., Masataka Kuroda,Reiko Watanabe,Tsuyoshi Esaki,Hitoshi Kawashima,Rikiya Ohashi,Tomohiro Sato,Teruki Honma,Hiroshi Komura,Kenji Mizuguchi, Drug discovery today, p. 103339-103339, 2022/08/13
  • Construction of the platform to explore drug target for IPF in Public/Private R&D Investment Strategic Expansion PrograM（PRISM）, Nakamura Yoshinori,Kitamura Hideya,Ogura Takashi,Natsume-Kitatani Yayoi,Mizuguchi Kenji, MEDCHEM NEWS, The Pharmaceutical Society of Japan, Vol. 32, No. 3, p. 119-123, 2022/08/01
  • Discovery of biological knowledge using TargetMine, Vol. 278, No. 6, p. 641-645, 2021/08/07
  • A public–private partnership to enrich the development of in silico predictive models for pharmacokinetic and cardiotoxic properties, Hiroshi Komura,Reiko Watanabe,Hitoshi Kawashima,Rikiya Ohashi,Masataka Kuroda,Tomohiro Sato,Teruki Honma,Kenji Mizuguchi, Drug Discovery Today, Elsevier BV, 2021/01
  • The importance of data in accelerating the drug discovery process using artificial intelligence (AI), Vol. 274, No. 9, p. 838-842, 2020/08/29
  • 【人工知能(AI)技術のヘルスケア利活用】新薬創出を加速するAIの開発, 夏目 やよい,水口 賢司, Precision Medicine, (株)北隆館, Vol. 3, No. 5, p. 410-413, 2020/05
  • 【イメージング時代の構造生命科学 細胞の動態、膜のないオルガネラ、分子の構造変化をトランススケールに観る】(第4章)活用可能なデータベースとプラットフォーム 対象タンパク質を理解するための有用なデータベース, 長尾 知生子,水口 賢司, 実験医学, (株)羊土社, Vol. 38, No. 5, p. 897-901, 2020/03
  • コンピュータサイエンスの応用 異なるデータベースの有機的統合と医療への応用, 藤原大,水口賢司, Lung Perspectives, Vol. 27, No. 3, p. 205-208, 2019/08
  • 創薬インフォマティクス 人工知能による創薬ターゲットの同定―“新薬創出を加速する人工知能の開発”プロジェクトの現状と課題, 野島陽水,水口賢司, 医学のあゆみ, Vol. 268, No. 12, p. 988-991, 2019/03
  • Data Warehousing with TargetMine for Omics Data Analysis, Yi-An Chen,Lokesh P. Tripathi,Kenji Mizuguchi, Methods in Molecular Biology, Springer New York, p. 35-64, 2019
  • Network-Based Analysis of Host-Pathogen Interactions, Lokesh P. Tripathi,Yi-An Chen,Kenji Mizuguchi,Eiji Morita, Encyclopedia of Bioinformatics and Computational Biology, Elsevier, 2019
  • Network-Based Analysis for Biological Discovery, Lokesh P. Tripathi,Yi-An Chen,Kenji Mizuguchi,Yoichi Murakami, Encyclopedia of Bioinformatics and Computational Biology, Elsevier, 2019
  • Integrative Analysis of Multi-Omics Data, Lokesh P. Tripathi,Tsuyoshi Esaki,Mari N. Itoh,Yi-An Chen,Kenji Mizuguchi, Encyclopedia of Bioinformatics and Computational Biology, Elsevier, 2019
  • 人工知能(AI)と小児医療 創薬とファーマコゲノミクス, 藤原大,水口賢司, 小児内科, Vol. 51, No. 1, p. 103-106, 2019/01
  • 【情報システム】インタラクトームレベルのデータセットを用いたタンパク質間相互作用予測とその応用, 村上 洋一,水口 賢司, 東京情報大学研究論集, 東京情報大学, Vol. 22, No. 1, p. 63-74, 2018/10
  • プレシジョンメディシンと創薬 5 創薬における計算機の果たす役割―プレシジョンメディシンに向けて―, 長尾知生子,夏目やよい,水口賢司, 月刊Precision Medicine, Vol. 1, No. 1, p. 28-31, 2018/10
  • 人工知能(AI)がもたらす創薬イノベーション 1.序文 ～LINCの設立とAI創薬～, 奥野恭史,水口賢司,本間光貴, 医薬ジャーナル, Vol. 54, No. 9, p. 2015-2017, 2018/09
  • 産学連携コンソーシアムLINC(Life Intelligence Consortium), Honma T,Mizuguchi K, faruaw, 公益社団法人 日本薬学会, Vol. 54, No. 9, p. 870-874, 2018
  • Generating Hypotheses for Biological Mechanisms Using Molecular Dynamics Simulations Can Promote Interdisciplinary Studies, Tsuchiya Y,Mizuguchi K, Journal of the Japan Society for Simulation Technology, 小宮山印刷工業, Vol. 36, No. 3, p. 139-144, 2017/09
  • Network analysis and in silico prediction of protein-protein interactions with applications in drug discovery, Yoichi Murakami,Lokesh P. Tripathi,Philip Prathipati,Kenji Mizuguchi, CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD, Vol. 44, p. 134-142, 2017/06
  • Editorial-Sequences and topology, R. Sowdhamini,Kenji Mizuguchi, CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD, Vol. 44, p. VII-VIII, 2017/06
  • Development of a Drug Discovery Informatics System: An Integrated Platform for Pharmacokinetic and Toxicological Modelling, 江崎剛史,渡邉怜子,川島和,夏目やよい,水口賢司, 薬剤学(Web), 公益社団法人 日本薬剤学会, Vol. 77, No. 4, p. 211‐215(J‐STAGE)-215, 2017
  • Database Development and Computational Modelling in Early-Stage Drug Discovery, MIZUGUCHI Kenji, TRENDS IN THE SCIENCES, 公益財団法人 日本学術協力財団, Vol. 22, No. 7, p. 7_62-7_65, 2017
  • 計算システム生物学による創薬:分子,構造からネットワークへ, 夏目やよい,水口賢司, 日本薬理学雑誌, 公益社団法人 日本薬理学会, Vol. 149, No. 2, p. 91‐95(J‐STAGE)-95, 2017
  • 公共データベースの統合からAIによるデータマイニングに向けて ‐創薬への応用を目指して‐, 伊藤眞里,長尾知生子,夏目やよい,水口賢司, CICSJ Bulletin (Web), Vol. 35, No. 3, 2017
  • Integrated toxicogenomics analysis with Toxygates for inferring molecular mechanisms, Yayoi Natsume-Kitatani,Johan Nyström-Persson,Yoshinobu Igarashi,Daisuke Satoh,Kenji Mizuguchi, Genomics and Computational Biology, Vol. 3, No. 1, p. 37-37, 2017
  • Systems Biology Approaches to a Rational Drug Discovery Paradigm, Philip Prathipati,Kenji Mizuguchi, CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBL LTD, Vol. 16, No. 9, p. 1009-1025, 2016
  • Integration of Disease Entries Across OMIM, Orphanet, and a Proprietary Knowledge Base, Maori Ito,Shin'ichi Nakagawa,Kenji Mizuguchi,Takashi Okumura, CURRENT APPROACHES IN APPLIED ARTIFICIAL INTELLIGENCE, SPRINGER-VERLAG BERLIN, Vol. 9101, p. 120-130, 2015
  • 今日から使えるデータベース・ウェブツール 第1章 データベースを探す/情報を探す, 小野浩雅,伊藤真和吏,坂東明日佳,木村考宏,大波純一,水口賢司, 実験医学, Vol. 32, No. 20, p. 3209-3222, 2014/12/10
  • ヒト多能性幹細胞から内胚葉分化誘導効率に優れた細胞株の選択方法, 岡村美菜子,柳原佳奈,AHMAD Shandar,劉有容,平田みつひ,水口賢司,二川浩樹,古江(楠田)美保, 口腔組織培養学会誌, Vol. 23, No. 1, p. 98-99, 2014/11/01
  • Identification Of Anti-Myxovirus Resistance Protein-1 Autoantibody As A Specific Marker For Idiopathic Nonspecific Interstitial Pneumonia, Y. Hamano,H. Kida,S. Ihara,H. Nishikawa,T. Arai,M. Hirose,L. P. Tripathi,T. Kimura,Y. Tada,Y. Yano,M. Mori,K. Mizuguchi,S. Sakaguchi,Y. Inoue,A. Kumanogoh, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, Vol. 189, 2014
  • 創薬支援のデータベースとバイオインフォマティクスによるデータ統合, 水口賢司, SAR News, No. 24, p. 2-6, 2013/04/01
  • A combined proteomics and computational approach provides a better understanding of HCV-induced liver disease, Lokesh P. Tripathi,Kenji Mizuguchi, EXPERT REVIEW OF PROTEOMICS, TAYLOR & FRANCIS LTD, Vol. 9, No. 5, p. 493-496, 2012/10
  • An Open Framework for Extensible Multi-stage Bioinformatics Software, Gabriel Keeble-Gagnere,Johan Nystroem-Persson,Matthew I. Bellgard,Kenji Mizuguchi, PATTERN RECOGNITION IN BIOINFORMATICS, SPRINGER-VERLAG BERLIN, Vol. 7632, p. 106-117, 2012
  • Quality control for human embryonic stem (ES) cell and induced pluripotent stem (iPS) cells on the bench, HIRATA Mitsuhi,AHMAD Shandar,SUGA Mika,FUJIKI Ayaka,MATSUMURA Hiroko,WAKABAYASHI Mari,UEDA Naoko,LIU Kehong,HAYASHIDA Midori,HIRAYAMA Tomoko,KOHARA Arihiro,YANAGIHARA Kana,MIZUGUCHI Kenji,K. FURUE Miho, TISSUE CULTURE RESEARCH COMMUNICATIONS, 日本組織培養学会, Vol. 30, No. 2, p. 145-157, 2011/12/31
  • ヒト胚性幹細胞,人工多能性幹細胞,間葉系幹細胞の細胞特性比較解析, 平田みつひ,林田みどり,館山大揮,小澤裕,松村紘子,家村将士,AHMAD Shandar,正札智子,金村米博,小原有弘,川端健二,水口賢司,水口裕之,古江(楠田)美保, 組織培養研究, Vol. 30, No. 1, 2011/03/31
  • Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display, Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 111-111, 2009/10
  • 次世代創薬テクノロジー 実践:インシリコ創薬の最前線 第2章 創薬インフォマティクス 1.構造・機能バイオインフォマティクスの新規創薬への応用, 水口賢司, 遺伝子医学MOOK, No. 14, p. 124-128, 2009/09/30
  • Benchmarking and Analysis of DNA-binding Site Prediction Using Machine Learning, Munazah Andrabi,Shandar Ahmad,Kenji Mizuguchi,Akinori Sarai, 2008 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS, VOLS 1-8, IEEE, p. 1745-+, 2008
  • A neurotrophin homolog in the central nervous system of Drosophila, Bangfu Zhu,Jenny Pennack,Peter McQuilton,Manuel G. Forero,Kenji Mizuguchi,Janine Fenton,Alicia Hidalgo, JOURNAL OF NEUROGENETICS, TAYLOR & FRANCIS LTD, Vol. 20, No. 3-4, p. 267-267, 2006/07
  • Fold recognition for drug discovery, Kenji Mizuguchi, Drug Discovery Today: TARGETS, Vol. 3, No. 1, p. 18-23, 2004/01/01
  • A Novel Superfamily that Catalyzes the Modification of Arginine, Shirai H,Mizuguchi K, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, Vol. 43, No. 2, p. 97-100, 2003/04
  • 研究紹介 バイオインフォマティクスによる蛋白質ファミリーの構造,機能へのアプローチ, 水口 賢司, 構造生物, 国際科学振興財団構造生物学坂部プロジェクト, Vol. 8, No. 3, p. 16-24, 2003
  • Cylindrical channels from concave helices, CR Calladine,Pratap, V,Chandran, V,K Mizuguchi,BF Luisi, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 299, No. 5607, p. 661-662, 2003/01
  • An informatic perspective on structural proteomics, Mizuguchi K, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 47, No. 8 Suppl, p. 1058-1063, 2002
  • From Genome to Structure: Challenges in Structural Bioinformatics, MIZUGUCHI Kenji, Nihon Kessho Gakkaishi, 日本結晶学会, Vol. 43, No. 1, p. 55-62, 2001/02/28
  • クリスタリット, 有富 正治,中迫 雅由,根岸 利一郎,小川 晋,小川 桂一郎,田村 類,田中 勲,田之倉 優,水口 賢司,近藤 忠,上江洲 由晃,古宮 聰,草塲 啓治,今井 基晴,河合 潤, 日本結晶学会誌, 日本結晶学会, Vol. 43, No. 2, p. 189-194, 2001
  • Genome analysis on the basis of protein structures, Shirai H,Mizuguchi K, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 共立出版, Vol. 46, No. 11 Suppl, p. 1496-1503, 2001/01
  • Structural genomics: an overview, TL Blundell,K Mizuguchi, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 73, No. 5, p. 289-295, 2000
  • N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family, K Mizuguchi,Dhanaraj, V,TL Blundell,AG Murzin, STRUCTURE WITH FOLDING & DESIGN, CURRENT BIOLOGY LTD, Vol. 7, No. 9, p. R215-R216, 1999/09
  • Watching the Rise of Structural Genomics, MIZUGUCHI Kenji, Seibutsu Butsuri, The Biophysical Society of Japan General Incorporated Association, Vol. 39, No. 2, p. 119-122, 1999/03
  • The insulin receptor: From protein sequence to structure, C. Marino-Buslje,M. Martin-Martinez,K. Mizuguchi,K. Siddle,T. L. Blundell, Biochemical Society Transactions, Vol. 27, No. 4, p. 715-726, 1999/01/01
  • Classification of protein 3D structures, K Kinoshita,K Mizuguchi,N Go, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 65, p. PA203-PA203, 1996
  • Seeking significance in three-dimensional protein structure comparisons, Kenji Mizuguchi,Nobuhiro Go, Current Opinion in Structural Biology, Vol. 5, No. 3, p. 377-382, 1995
  • COLLECTIVE MOTIONS IN PROTEINS INVESTIGATED BY X-RAY DIFFUSE-SCATTERING, K MIZUGUCHI,N GO, COMPUTER AIDED INNOVATION OF NEW MATERIALS II, PTS 1 AND 2, ELSEVIER SCIENCE PUBL B V, p. 1291-1294, 1993

Publications

  • 健康と疾患を制御する精密栄養学 : 「何を、いつ、どう食べるか?」に、食品機能の解析と個人差を生む分子メカニズムの解明から迫る, 陳 怡安,朴 鐘旭,水口賢司, 羊土社, ISBN:9784758104111, 2023/06/05
  • ケモインフォマティクスにおけるデータ収集の最適化と解析手法, 村上洋一,長尾知生子,水口賢司, 技術情報協会, ISBN:9784861049446, 2023/04
  • 革新的AI創薬 : 医療ビッグデータ、人工知能がもたらす創薬研究の未来像, 夏目やよい,水口賢司, エヌ・ティー・エス, ISBN:9784860437886, 2022/07
  • 創薬研究のための相互作用解析パーフェクト : 低中分子・抗体創薬におけるスクリーニング戦略と実例、in silico解析、一歩進んだ分析技術まで, 長尾知生子,李 秀栄,水口賢司, 羊土社, ISBN:9784758122566, 2021/12
  • Protein Interactions: Computational Methods, Analysis and Applications, Arina Afanasyeva,Chioko Nagao,Kenji Mizuguchi, World Scientific, 2020/03
  • 人と共生するAI革命 : 活用事例からみる生活・産業・社会の未来展望, 江崎剛史,渡邉怜子,夏目やよい,伊藤眞里,長尾知生子,川島和,水口賢司, エヌ・ティー・エス, ISBN:9784860436087, 2019/06
  • IT・ビッグデータと薬学 : 創薬・医薬品適正使用への活用, 日本学術協力財団, 2019
  • マテリアルズ・インフォマティクスによる 材料開発と活用集, 渡邉怜子,江崎剛史,夏目やよい,佐藤朋広,長尾知生子,川島和,水口賢司, 技術情報協会, ISBN:9784861047329, 2019/01
  • iｎ ｓｉｌｉｃｏ創薬における スクリーニングの高速化・高精度化技術, 村上洋一,水口賢司, 技術情報協会, ISBN:9784861046889, 2018/01
  • 次世代アジュバント開発のためのメカニズム解明と安全性評価, 夏目やよい,水口賢司, シーエムシー出版, ISBN:9784781312385, 2017/03
  • 生命科学から創薬へのイノベーション, 水口賢司, 南山堂, ISBN:9784525134518, 2014/10
  • Pharmaceutical data mining : approaches and applications for drug discovery, Munazah Andrabi,Chioko Nagao,Kenji Mizuguchi,Shandar Ahmad, Wiley, ISBN:9780470196083, 2009/12
  • コンピューターで薬を創ろう, 水口賢司, ケイ・ディー・ネオブック, 化学同人 (発売), ISBN:9784759803471, 2009/06
  • Computational biology : new research, Shirai, H,Mizuguchi, K,Kuroda, D,Nakamaura, H,Soga, S,Kobori,M. Hirayama, N, Nova Science Publishers, ISBN:9781606920404, 2009
  • タンパク質結晶の新展開 : 新しい育成技術から構造解析・応用研究へ, 水口賢司,長尾知生子, シーエムシー出版, ISBN:9784781300245, 2008/05
  • Encyclopedia of genetics, genomics, proteomics and bioinformatics, MIZUGUCHI Kenji, J. Wiley, ISBN:9780470849743, 2005
  • Protein structure prediction : bioinformatic approach, Miguel R.N,Shi J,Mizuguchi K, International University Line, ISBN:096368177X, 2002

Industrial Property Rights

  • エピトープ均質化抗体パネル、ならびにその作製方法および利用, 近藤 裕郷,鎌田 春彦,永田 諭志,水口 賢司,村上 洋一,津本 浩平,秋葉 宏樹, JP2017041683, 出願日:2017/11/20
  • 遺伝子絞り込み装置、遺伝子絞り込み方法、及びコンピュータプログラム, 水口賢司,陳 怡安,ロケシュ・パティ・テリパチ, 特願2011-184289, 出願日:2011/08/26
  • 遺伝子絞り込み装置、遺伝子絞り込み方法、及びコンピュータプログラム, 水口賢司,陳 怡安,ロケシュ・パティ・テリパチ, 特許第5930266号, 特願2011-184289, 出願日:2011/08/26

Awards

  • Japan Open Innovation Prize（JOIP）, 2020/02
  • Research Career Development Fellowship, Wellcome Trust, 2000/06
  • Long-Term fellowship, HFSP (Human Frontier Science Program), 1996/10

Presentations

  • ナノ粒子の安全性予測, The 144th Annual Meeting of the Pharmaceutical Society of Japan, 2024/03/30
  • Data integration and curation as a basis for Artificial Intelligence-based drug discovery, Kenji Mizuguchi, 23rd Annual Conference of the Life Science Association of Chinese in Japan, 2024/01/20
  • AI創薬の基礎としてのデータベースと多面的モデリング, 水口賢司, 令和5年度 第2回 産学官連携情報交流セミナー, 2023/12/18
  • データ統合と多面的モデリングによるAI創薬, The 51st Annual Meeting of the Japanese Society of Clinical Immunology, 2023/10/06
  • DruMAP : a Novel Drug Metabolism and Pharmacokinetics Analysis Platform, Kenji Mizuguchi, 2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics [2023 ICCP450/JSSX], 2023/09/29
  • データ駆動型と原理ベース型モデリングの融合によるAI 創薬, 2023/06/01
  • AlphaFold時代のライフサイエンス, Digital Health Seminar, 2023/03/20
  • Data integration for drug discovery, IPR x RIKEN (BDR) Symposium 2023 Dive into Data of Life, 2023/02/21
  • AI 創薬におけるデータ統合, Kenji Mizuguchi, 2023/02/04
  • Towards new modalities in drug discovery with AI-based modeling, Kenji Mizuguchi, IPR Seminar: Frontier of Dynamic Structural Biology, 2022/10/18
  • AI platform development at ArCHER, 2022/07/07
  • AI創薬の基盤とデータ統合, 水口 賢司, 構造活性フォーラム2022, 2022/06/03
  • DruMAP: a novel drug metabolism and pharmacokinetics analysis platform, Accelerate Vigyan Sponsored High End Workshop on Artificial Intelligence in Drug Discovery: Quickening the Pace from Bench to Bedside, 2022/05/25
  • 計算生物学からAI創薬へ, 水口 賢司, 第１回ADS研究報告会, 2022/03/10
  • 計算生物学の創薬応用, 水口 賢司, R022 量子構造生物学委員会 第4回研究会, 2021/12/23
  • コンピュータ、AIと創薬, 水口 賢司, 日本薬学会関西支部市民公開講座Web配信
  • バイオ・ケモインフォマティクスの応用：コンピュータ創薬を例として, 水口 賢司, ライフサイエンス技術部会 材料分科会 勉強会, 2021/11/26
  • 薬物動態統合解析プラットフォームDruMAP, 2021/11/12
  • Towards better explanation and generalization in computational drug discovery, 2021/08/31
  • AI創薬に向けたデータ統合, 水口賢司, 創薬懇話会 2021 in 京都, 2021/06/25
  • AI-driven drug discovery, Kenji Mizuguchi, 2021/06/23
  • Data integration and AI-driven drug discovery, Kenji Mizuguchi, 「Pharmaceutical Sciences in a Pandemic World」, 2021/06/03
  • AI創薬に向けた多角的アプローチ, 水口賢司, 第17回日本臨床プロテオゲノミクス研究会, 2021/05/29
  • ヘルスケア分野におけるデータ活用と診断への応用, 水口賢司, バイオグリッド研究会2021 パネルディスカッション, 2021/05/22
  • AI創薬におけるデータベースの役割, 水口 賢司, 第23回IPSN講演会, 2021/03/31
  • コンピュータ、AIと創薬, 水口 賢司, 第13回ケムステVシンポジウム, 2020/12/18
  • ライフインテリジェンスコンソーシアム（LINC）における創薬医療 AI の開発 －創薬テーマ創出から臨床への橋渡しと知識ベース－ イントロダクション, 水口 賢司, CBI学会2020年大会, 2020/10/28
  • バイオサイエンスデータベース、10年の軌跡とこれから, 水口 賢司, トーゴーの日シンポジウム2020, 2020/10/05
  • 創薬支援のための統合データベース, 水口 賢司, 2020年日本バイオインフォマティクス学会年会 第９回生命医薬情報学連合大会IIBMP2020, 2020/09/03
  • 創薬の加速化に向けたAI基盤とデータ統合, データ関連人材育成事業, 水口 賢司, 第１回MD-DSC研究会, 2020/07/07
  • DruMAP: 薬物動態予測の統合解析プラットフォーム, 水口賢司, 第47回 日本毒性学会学術年会, 2020/06/30
  • 創薬研究へのAI活用, 水口 賢司, ILSI Japan先端技術シンポジウム, 2020/02/21
  • 疾患・創薬研究におけるデータベースとAI活用, 水口 賢司, 日本臨床試験学会 第１１回学術集会総会, 2020/02/14
  • 健康・医薬研究の基盤としてのデータ統合と人工知能活用,, 水口 賢司, 神戸大学遠隔インタラクティブ講義「計算生命科学の基礎Ⅵ」, 2019/12/18
  • 健康・医薬研究へのAI活用, 水口 賢司, 第４回知的財産委員会セミナー, 2019/11/20
  • 健康・医薬研究の基盤としてのデータ統合とAI活用, 水口 賢司, 第五回シナジーセミナー, 2019/11/18
  • Artificial intelligence-based drug discovery: challenges and applications to target identification and pharmacokinetic modelling, 2019/11/14
  • 創薬デザインの基盤としてのデータ統合とAI活用, 水口 賢司, 第2回モダリティ創薬デザイン研究会シンポジウム, 2019/11/12
  • Data integration and computational systems approaches to drug discovery, 6th International Symposium on Diffraction Structural Biology (ISDSB2019), 2019/10/20
  • Data integration as a basis for artificial intelligence in drug discovery, 2019/10/02
  • 薬物動態統合解析プラットフォームとデータベース：その臨床活用に向けて, 水口 賢司, 第５回日本医薬品安全性学会学術大会, 2019/07/28
  • どれを標的にするか、どこを標的にするか？タンパク質間相互作 用標的がん治療創薬を加速させる異分野融合, 片桐豊雅,水口賢司, 第１９回日本蛋白質科学会年会・第７１回日 本細胞生物学会大会合同年次大会, 2019/06/25
  • AI創薬基盤としてのデータ統合とデータベース開発, 水口 賢司, ゲノム創薬・創発フォー ラム第１回シンポジウム, 2019/06/18
  • AI・インフォマティクスの創薬への活用, 水口 賢司, MetaCoreユーザー会, 2019/06/05
  • AI創薬の基礎としてのデータ統合とモデリング, 水口 賢司, 第６回NPO法人京都コモンズ 会員セミナー, 2019/05/29
  • 薬物動態データベースの臨床活用に向けて, 水口賢司, 日本薬学会第139年会シンポジウム, 2019/03/22
  • データ統合と計算システム生物学による創薬, 水口賢司, バイオインタラクション研究会 第４回ワークショップ, 2019/03/14
  • マイクロバ イオームと表現型データの統合解析プラットフォーム, 水口賢司, Meta-Omics Workshop in Kyoto, 2019/03/09
  • インフォマティクスの活用による新薬創出の加速を目指して, 水口賢司, 第５回インター フェックス大阪, 2019/02/21
  • AI・インフォマティクスによる新薬創出の加速を目指して, 水口賢司, ヒューマンサイエンス振興財団第２回講演会, 2019/02/19
  • 計算生物学と創薬のためのデータ統合, 水口賢司, シンポジウム「理論生物物理学の現在と未来」, 2019/02/14
  • ＡＩ開発基盤としてのデータ統合：薬物動態モデリングとターゲット探索, 水口賢司, 第１回日本メディカルＡＩ学会学術集会, 2019/01/25
  • 創薬支援インフォマティクスシステム構築とは？, 水口賢司, 創薬支援ネットワーク産学連携フォーラム, 2019/01/24
  • データ統合と人工知能技術による新薬創出の加速, 水口賢司, 彩都産学官連携フォーラム, 2019/01/23
  • 薬物動態・ 毒性予測のための統合解析プラットフォーム, 水口賢司, 日本毒性学会 第1回 医薬品毒性機序研究会, 2019/01/10
  • 医薬基盤・健康・栄養研究所におけるAI開発基盤, 水口賢司, 平成30年度 第２回 関薬協 研究開発推進会議, 2018/12/04
  • Data integration as a basis for computational modelling for rational drug discovery, Kenji Mizuguchi, The 18th KIAS Conference on Protein Structure and Function, 2018/11/17
  • 創薬研究のためのAI活用：薬物動態モデリングとターゲット探索, 水口賢司, 関西医薬品協会 第２回AI創薬の最新状況に関する講演会, 2018/10/22
  • 薬物動態・毒性予測の統合プラットフォームと企業連携, 水口賢司, CBI学会2018年大会, 2018/10/09
  • 創薬におけるAI利活用, 水口賢司, CBI学会（情報計算化学生物学会）2018年大会, 2018/10/09
  • 創薬・疾患研究のためのデータ統合の実際, 水口賢司, トーゴーの日シンポジウム2018, 2018/10/05
  • Data integration and computational modelling for drug discovery, Kenji Mizuguchi, 2018/10/04
  • Data integration and computational systems approaches towards rational drug discovery, Kenji Mizuguchi, InCoB 2018, 2018/09/26
  • ライフインテリジェンスコンソーシアム（LINC）におけるAI開発の現状, 水口賢司, ライフインテリジェンスコンソーシアム（LINC）2018年度第１回全体報告会, 2018/09/10
  • Data integration and computational systems approaches to target discovery and pharmacokinetic modelling, 日英セミナー Big Data and AI in Drug Discovery: Resources and Developments, 2018/07/25
  • タンパク質インフォマティクスのためのデータ統合, 水口賢司, 第18回日本蛋白質科学会年会, 2018/06/27
  • 分子デザインに向けたAI基盤の構築, 水口賢司, 第5回関西創薬化学コミュニティー親睦会, 2018/02/02
  • 創薬の加速化に向けたAI共通基盤の構築, 水口賢司, 第14回 Pharma AI Forum （PHAIFO), 2018/01/25
  • 計算システム生物学と創薬, 水口賢司, 遠隔インタラクティブ講義「計算生命科学の基礎 Ⅳ」, 2018/01/10
  • 創薬・健康・栄養 研究を支援するNIBIOHNのデータベース, 水口賢司, 2017年度生命科学系学会合同年次大会 （ConBio2017）, 2017/12/06
  • 生体分子間相互作用の解析・予測から分子デザインへ, 水口賢司, NIBIOHN創薬デザインセンターシンポジウム, 2017/11/21
  • データ統合と多階層モデリングによる創薬の効率化, 水口賢司, 徳島大学研究クラスター 統合的がん創薬研究クラスター 特別セミナー, 2017/11/14
  • 日本、英国でのキャリア形成と医薬基盤・健康・栄養研究所における創薬研究, 水口賢司, 立命館大学 薬学部創薬科学科, 2017/10/30
  • 多階層データの統合モデリングによる薬物動態予測 システムの構築, 水口賢司, CBI学会2017年大会フォーカストセッション, 2017/10/05
  • Data integration and statistical/ab initio modeling towards rational drug discovery, Kenji Mizuguchi, The 55th Annual Meeting of the Biophysical Society of Japan, 2017/09/20
  • タンパク質立体構造の比較とデータベース, 水口賢司, 第386回CBI学会講演会, 2017/07/21
  • Drug discovery with databases for pharmacokinetic modelling and toxicity prediction, MIZUGUCHI Kenji, Annual Meeting of the Japanese Society of Toxicology, 2017/07/10
  • データ統合と計算生物学による合理的創薬に向けて, 水口賢司, 東京大学分子細胞生物学研究所セミナー, 2017/03/15
  • 創薬の初期研究におけるデータベース構築とモデリング, 水口賢司, 日本学術会議薬学委員会シンポジウム,, 2017/01/13
  • 計算生物学によるシステムの理解からの創薬への展開, 水口賢司, 神戸大学計算科学教育センター 遠隔インタラクティブ講義（計算生命科学の基礎Ⅲ）, 2017/01/10
  • 創薬インフォマティクスからのAIへの期待, 水口賢司, 日本オミックス医療学会シンポジウム, 2016/12/14
  • 創薬支援インフォマティクスシステム：体内動態、毒性の統合データベースと予測, 水口賢司, 創薬等支援技術基盤プラットフォーム公開シンポジウム, 2016/12/07
  • データ駆動型の構造・相互作用・機能予測から創薬へ, 水口賢司, 国立研究開発法人 医薬 基盤・健康・栄養研究所 創薬デザイン研究センターシンポジウム, 2016/11/22
  • 薬物動態・毒性の予測プラットフォームを目指して創薬支援インフォマティクスシステム構築プロジェクトの紹介, 水口賢司, CBI学会2016年大会フォーカストセッション, 2016/10/27
  • データ統合は創薬インフォマティクスを如何に推進するか, 水口賢司, CBI学会2016大会, 2016/10/27
  • 計算システム生物学による創薬：分子、構造からネットワークへ, 水口賢司, ２０１６年度第1回バイオ単分子研究会, 2016/10/23
  • 健康な日本人の腸管免疫と腸内細菌データベースの構築, 水口賢司, マイクロバイオーム公開セミナー（１）, 2016/10/21
  • 創薬研究におけるデータ統合、データベース構築と薬物動態モデリング, 水口賢司, 日本薬物動態学会, 2016/10/13
  • データベース、バイオインフォマティクスから呼吸器疾患へ, 水口賢司, 第23回日本免疫毒性学会学術年会, 2016/09/06
  • データ統合と計算ネットワーク生物学による創薬研究, 水口賢司, 第１５回国際バイオテクノロジー展（アカデミックフォーラム）, 2016/05/12
  • データ統合と計算ネットワーク生物学による呼吸器疾患へのアプローチ, 水口賢司, 第56回日本呼吸器学会学術講演会, 2016/04/10
  • 構造からネットワークへ：計算生物学による創薬研究, 水口賢司, 日本学術振興会構造生物169委員会 第４９回研究会, 2016/03/09
  • アジュバント空間の解析を可能にする統合データベース, 水口賢司, 第9回次世代アジュバント研究会, 2016/01/19
  • 健康な日本人の生活習慣と腸管免疫・腸内細菌データベースの構築：バイオインフォマティクスの視点から, 水口賢司, シリーズ「薬づくりの新しいR&Dモデルを探る」第１１回「薬づくりと健康食品開発を結ぶ」, 2016/01/15
  • 医薬基盤・健康・栄養研究所の創薬支援データベースとツール, 水口賢司, 第38回日本分子生物学会年会 第88回日本分子生化学会大会 合同大会, 2015/12/01
  • データ統合と計算の融合による創薬研究, 水口賢司, バイオスーパーコンピューティング神戸2015, 2015/11/30
  • 計算システム生物学によるポリファーマコロジーへのアプローチと新たな合理的創薬パラダイム, 水口賢司, CBI学会大会, 2015/10/26
  • 計算生物学による分子認識と生体応答の予測：がん創薬に向けて, 水口賢司, 第２回 次世代がんインフォマティクス研究会, 2015/09/11
  • データウェアハウスによる創薬関連データ統合と解析の実際, 水口賢司, CBI学会研究講演会, 2015/04/24
  • 計算生物学によるシステムの理解から創薬へ, 水口賢司, 第２回 関西ライフサイエンス・リーディングサイエンティストセミナー, 2014/12/15
  • 計算生物学による創薬を目指して, 水口賢司, IPABシンポジウム, 2014/12/05
  • 乳癌細胞増殖の分子機構解明から創薬へ:タンパク質構造と相互作用予測による主導, 水口賢司, CBI学会大会, 2014/10/28
  • Computational and systems approaches to early stage drug discovery, 2014/05/16
  • バイオインフォマティクスによるシステムの理解から創薬へ, 水口賢司, 徳島大学 疾患プロテオゲノム研究センター, 2014/05/16
  • 計算生物学によるシステムの理解から創薬へ, 水口賢司, 京都大学理学部, 2014/02/18
  • データベースは、創薬初期でのターゲット評価と安全性の予測に役立つか？, 水口賢司, 「創薬研究におけるバイオデータベース講習会」（第三回データベース講習会＠大阪）, 2014/01/24
  • ‘アジュバントゲノミクス’に向けた統合データベースの現状, 水口賢司, 第7回次世代アジュバント研究会, 2014/01/21
  • 創薬の初期研究におけるデータ統合：ターゲットと安全性の評価, 水口賢司, 第345回 CBI学会研究講演会, 2014/01/09
  • データ統合とネットワーク解析による創薬支援, 水口賢司, 第9回霊長類医科学フォーラム, 2013/11/14
  • データ統合とネットワーク解析による創薬初期研究の支援, 水口賢司, 第3回シスメックスプロテインカンファレンス, 2013/10/18
  • Computational and systems approaches to early stage drug discovery, 水口賢司, 九州大学 生体防御医学研究所附属生体多階層システム研究センター, 2013/09/25
  • Data integration and protein network analysis for early stage drug discovery, Structural Life Science 7th International Conference on Structural Genomics (ICSG2013-SLS), 2013/07/31
  • 創薬支援のためのデータ統合とデータベース開発, 水口賢司, 東北大学大学院情報科学研究科, 2013/07/10
  • 医薬基盤研における創薬支援データベースの開発, 水口賢司, シリーズ研究講演会「薬づくりの新しいＲ＆Ｄモデルを探る」第１回, 2013/06/20
  • 創薬につながるバイオインフォマティクス, 水口賢司, 統合データベース講習会：AJACS駿河, 2013/01/13
  • 生体膜周辺のネットワークと創薬支援バイオインフォマティクス, 水口賢司, 生体膜と薬物の相互作用シンポジウム講演要旨集, 2012/11/15

Media Coverage

  • α-アミノ酸合成法開発 中分子ペプチド薬の創出へ 九大などグループ, 薬事日報, 2022/04/13
  • 「創薬標的候補の探索成功 臨床情報DBをAIで解析 PRISM研究チーム」, 2021/07/30
  • 「創薬AIオープン基盤 医薬健栄研・理研 年度末に運用 間質性肺炎薬で成果」, 2021/07/20
  • 「AI×iPS＝新薬候補 時間大幅短縮・ALS 治療に期待」, 2020/11
  • 「創薬 AI が実用化段階に、製薬企業の利用促進へ 基盤研など、来年度からオープンプラットフォーム 運用開始」, 2020/09
  • 「創薬標的探索へ大規模 DB 特発性肺線維症の層別化も」, 2020/07
  • 「LINC に厚労大臣賞 新薬開発過程を AI 化 オープンイノベ大賞」, 2020/02
  • 「データの統合・整備と人材育成を推進 AI 健康・医薬研究センター」, 2020/02
  • 「基盤研の AI 研究センター 創薬プロセスでプロジェクト進行」, 2020/02
  • 「公知データ統合に注力 AI センター発足でシンポ」, 2020/02
  • 「創薬ターゲット探索に AI で挑む 第 2 回日本メディカル AI 学会の話題から」, 2020/02
  • 「運動・睡眠に続け、AI と量子コンピューターで挑む「人に寄り添う」新領域」, 2020/02
  • 「腸内細菌データベースを拡大へ、 健康増進・予防に期待、栄養研」, 2020/01
  • 「腸内細菌の情報収集拡大、健康増進・病気予防に期待 栄養研」, 2020/01
  • 「腸内細菌情報 収集拡大へ」, 2020/01
  • 「ライフインテリジェンスコンソーシアム（LINC）AIを組み合わせて創薬のコスト削減と開発期間短縮をめざす」, 2019/11
  • 「AI創薬コスト半減」, 2019/10
  • 「100社で挑む創薬AI、初の商用化事例を披露するも課題は山積み」, 2019/10
  • 「AI創薬の異業種連携進む‐十分なデータ確保に課題 ライフインテリジェンスコンソーシアム」, 2019/10
  • 「基盤研や富士通九州の創薬支援システム、明薬も参画」, 2019/10
  • 「【医薬基盤研】バイオ薬から低分子薬へ 人工核酸アプタマーを活用 国内製薬の創薬”突破口”に」, 2019/02
  • 関薬協が２度目のAI創薬講演会、会員会社の関心高く, 2018/10
  • 「基盤研、製薬7社と薬物動態・毒性のDB構築 予測モデル作成も」, 2018/10
  • 「企業と連携し予測モデル確立へ」, 2018/10
  • 基盤研, IPF治療薬探索DBで省庁横断プロジェクト, 2018/08
  • 新薬創出加速へAI開発、肺がんとIPFで 省庁連携プロジェクト、21年度までに構築, 2018/08
  • 基盤研など 創薬標的発見へAI開発 肺癌と突発性肺線維症が対象 21年度メド に一つ以上目標, 2018/08
  • AIを主戦場にしないと世界とは戦えない, 2018/01
  • 製薬業界 AI創薬の波, 2017/12
  • LINC、3年後めどに「創薬AI」構築へ, 2017/11
  • AI創薬へ、用語集や文献データ集積など構想 AMED 来年度まで, 2017/09
  • 基盤研、AI活用で標的探索を自動化 アンメットニーズの創薬を後押し, 2017/08
  • 基盤研、創薬AI開発へ, 2017/06
  • 新薬の候補物探索 スパコン・AIが活躍, 2017/03
  • 動き出す 積年の課題 2017年医療 AIが探る がん・認知症の最適治療, 2017/01
  • 創薬支援システム構築、AI活用に期待 NIBIOHN 水口氏, 2016/12
  • １分子構造変化による細胞集団運動制御機構, 2016/11
  • 新薬創出で人工知能活用 創薬ターゲットの枯渇解消 概算要求で 3.5億円要求, 2016/09
  • 新薬候補ＡＩが提案, 2016/09
  • 基盤研、新薬創出で人工知能を開発 (厚労省が概算要求へ 新研究室は補正で●補正で創薬共同施設も ベンチャーも利用可, 2016/08
  • 創薬ターゲット同定、人工知能開発に3.5億円 基盤研事業で厚労省・概算要求, 2016/08
  • アジュバント研究、製薬企業のニーズしっかり聴く 次世代研究会, 2016/01
  • 薬物動態が毒性等を予測 創薬支援ネット協議会 AMEDがシステム開発へ, 2015/10

Committee Memberships

  • 日本バイオインフォマティクス学会, 幹事、第11回生命医薬情報学連合大会（IIBMP2022）大会長, 2021/04 - Present
  • 日本学術振興会, R022 量子構造生物学委員会 学会委員, 2020/04 - Present
  • 日本メディカルAI学会, 評議員, 2019/04 - Present
  • ライフ インテリジェンス コンソーシアム（LINC）, 副代表, 2017 - Present
  • Chem-Bio Informatics Society, Board member, 2014/04 - Present
  • 国立研究開発法人 理化学研究所, 計算科学研究センター アドバイザリー・カウンシル, 2023/03 - 2024/03
  • 国立遺伝学研究所ＮＢＲＰ事務局, ナショナルバイオリソースプロジェクト 課題評価委員会委員, 2021/05 - 2022/04
  • JSTバイオサイエンスデータベースセンター（NBDC）, 統合化推進プログラム 研究アドバイザー, 2017/04 - 2020/03
  • 日本生物物理学会, 分野別専門委員, 2015/04 - 2016/03
  • 日本バイオインフォマティクス学会, 評議員, 2007/04 - 2009/03
  • 文部科学省, 新学術領域研究専門委員会 委員, -
  • 内閣府 総合科学技術・イノベーション会議, 評価専門調査会「個別化医療に向けた次世代医薬品創出基盤技術開発」フォローアップ検討会委員, -
  • 内閣府, 「個別化医療に向けた次世代医薬品創出基盤技術開発」評価検討会委員, -
  • 日本医療研究開発機構 (AMED), 課題評価委員, -
  • 日本学術振興会, 科学研究費委員会専門委員（第二段審査）, -