顔写真

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Nakajima Kichitarou
中島　吉太郎
Nakajima Kichitarou
中島　吉太郎
Institutional repository
Graduate School of Engineering　Division of Precision Science & Technology and Applied Physics, Assistant Professor

keyword amyloidosis，Sonochemistry

Institutional repository

Research History 6

  1. 2023/01 - Present
    Osaka University

  2. 2022/06 - Present
    Osaka University　Microsonochemistry Research Joint Chair

  3. 2023/10 - 2024/09
    University of Cambridge　Department of Chemistry　Visiting Researcher

  4. 2020/04 - 2022/05
    Osaka University　Global Center of Medical Engineering Infomatics

  5. 2019/07 - 2020/03
    Osaka University　Graduate School of Engineering Science Department of Mechanical Science and Bioengineering Division of Mechanical Engineering

  6. 2017/04 - 2019/06
    シスメックス株式会社　中央研究所

Education 4

  1. Osaka University

    2015/04 - 2017/03

  2. Osaka University

    2014/04 - 2015/03

  3. Osaka University

    2012/04 - 2014/03

  4. Wakayama National College of Technology

    2007/04 - 2012/03

Committee Memberships 1

  1. 超音波エレクトロニクスの基礎と応用に関するシンポジウム 現地実行委員

    2019/04 - 2020/03

Research Areas 3

  1. Nanotechnology/Materials / Basic physical chemistry / amyloid fibril

  2. Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Machine materials and mechanics / Ultrasonic measurement

  3. Nanotechnology/Materials / Applied physics - general / Sonochemistry

Awards 2

  1. 若手奨励賞優秀賞

    日本蛋白質科学会　2023/07

  2. Young Scientist Award

    Symposium on UltraSonic Electronics (USE2020)　2020/12

Papers 26

  1. Ultrasonic detection of α-synuclein amyloid seeds from a highly crowded environment.

    Tomoki Ota, Kichitaro Nakajima, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi

    Biophysical journal　2025/06/10　Research paper (scientific journal)

  2. Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds

    Kichitaro Nakajima, Tomoki Ota, Hajime Toda, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi

    ACS Chemical Neuroscience　2024/03/28　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  3. Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

    Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto

    Nature Communications　Vol. 13　No. 1　2022/10　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  4. Visualization of Optical Vortex Forces Acting on Au Nanoparticles Transported in Nanofluidic Channels

    Kichitaro Nakajima, Tempei Tsujimura, Kentaro Doi, Satoyuki Kawano

    ACS Omega　Vol. 7　No. 3　p. 2638-2648　2022/01/10　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  5. Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction

    Kichitaro Nakajima, Hajime Toda, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi

    ACS Chemical Neuroscience　2021/09/01　Research paper (scientific journal)

  6. Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation.

    Kichitaro Nakajima, Kentaro Noi, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi, Yuji Goto

    Ultrasonics sonochemistry　Vol. 73　2021/05　Research paper (scientific journal)

  7. Synchronized resistive-pulse analysis with flow visualization for single micro- and nanoscale objects driven by optical vortex in double orifice.

    Kichitaro Nakajima, Ryoji Nakatsuka, Tetsuro Tsuji, Kentaro Doi, Satoyuki Kawano

    Scientific reports　Vol. 11　No. 1　p. 9323-9323　2021/04/29　Research paper (scientific journal)

  8. Time-Resolved Observation of Evolution of Amyloid-β Oligomer with Temporary Salt Crystals

    Kichitaro Nakajima, Tomoya Yamazaki, Yuki Kimura, Masatomo So, Yuji Goto, Hirotsugu Ogi

    Journal of Physical Chemistry Letters　Vol. 11　No. 15　p. 6176-6184　2020/08/06　Research paper (scientific journal)

  9. Drastic acceleration of fibrillation of insulin by transient cavitation bubble

    Kichitaro Nakajima, Daisuke Nishioka, Masahiko Hirao, Masatomo So, Yuji Goto, Hirotsugu Ogi

    Ultrasonics Sonochemistry　Vol. 36　p. 206-211　2017/05/01　Research paper (scientific journal)

  10. Optimized Ultrasonic Irradiation Finds Out Ultrastable Aβ1-40 Oligomers

    Kichitaro Nakajima, Masatomo So, Kazuma Takahashi, Yoh Ichi Tagawa, Masahiko Hirao, Yuji Goto, Hirotsugu Ogi

    Journal of Physical Chemistry B　Vol. 121　No. 12　p. 2603-2613　2017/03/30　Research paper (scientific journal)

  11. Nucleus factory on cavitation bubble for amyloid β fibril

    Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi, Yuji Goto

    Scientific Reports　Vol. 6　2016/02/25　Research paper (scientific journal)

  12. Conformational Switch in the Alpha-Synuclein C-Terminal Domain Directs Its Fibril Polymorphs.

    Cesar Aguirre, Yohei Miyanoiri, Masatomo So, Hajime Tamaki, Takahiro Maruno, Junko Doi, Nan Wang, Keiichi Yamaguchi, Kichitaro Nakajima, Yu Yamamori, Hiroko Inoura, Chi-Jing Choong, Keita Kakuda, Takahiro Ajiki, Yasuyoshi Kimura, Tatsuhiko Ozono, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Hirotsugu Ogi, Susumu Uchiyama, Yoh Matsuki, Kentaro Tomii, Yuji Goto, Kensuke Ikenaka, Hideki Mochizuki

    Chemistry (Weinheim an der Bergstrasse, Germany)　2025/05/23　Research paper (scientific journal)

  13. Mechanism of amyloid fibril formation triggered by breakdown of supersaturation

    Keiichi Yamaguchi, Kichitaro Nakajima, Hirotsugu Ogi, Yuji Goto

    npj Biosensing　Vol. 2　No. 1　2025/02/03　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  14. Accelerated amyloid fibril formation at the interface of liquid-liquid phase-separated droplets by depletion interactions.

    Keiichi Yamaguchi, Joji Mima, Kichitaro Nakajima, Hiroki Sakuta, Kenichi Yoshikawa, Yuji Goto

    Protein science : a publication of the Protein Society　Vol. 34　No. 2　2025/02　Research paper (scientific journal)

  15. Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis.

    Suguru Yamamoto, Keiko Yamamoto, Yoshitoshi Hirao, Keiichi Yamaguchi, Kichitaro Nakajima, Mami Sato, Miho Kawachi, Mio Domon, Kei Goto, Kentaro Omori, Noriaki Iino, Hisaki Shimada, Ryuzi Aoyagi, Isei Ei, Shin Goto, Yuji Goto, Fumitake Gejyo, Tadashi Yamamoto, Ichiei Narita

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis　p. 1-11　2024/02/11　Research paper (scientific journal)

  16. Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation.

    Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi

    Journal of molecular biology　p. 168475-168475　2024/02/02　Research paper (scientific journal)

  17. Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor

    Lianjie Zhou, Touko Hajiri, Kichitaro Nakajima, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi

    ACS Sensors　2023/06/26　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  18. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

    Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

    Acta neuropathologica　Vol. 145　No. 5　p. 573-595　2023/03/20　Research paper (scientific journal)

  19. Mechanisms of polyphosphate-induced amyloid fibril formation triggered by breakdown of supersaturation

    Keiichi Yamaguchi, Kichitaro Nakajima, Yuji Goto

    Biophysics and Physicobiology　Vol. 20　No. 1　p. n/a-n/a　2023　Research paper (scientific journal)

    Publisher: Biophysical Society of Japan

  20. Supersaturation-Dependent Formation of Amyloid Fibrils

    Yuji Goto, Masahiro Noji, Kichitaro Nakajima, Keiichi Yamaguchi

    Molecules　Vol. 27　No. 14　p. 4588-4588　2022/07/19　Research paper (scientific journal)

    Publisher: MDPI AG

  21. Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

    Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki

    bioRxiv　2022/02/10　Research paper (scientific journal)

    Publisher: Cold Spring Harbor Laboratory

  22. Development of HANABI, an ultrasonication-forced amyloid fibril inducer

    Yuji Goto, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi

    Neurochemistry International　Vol. 153　2022/02　Research paper (scientific journal)

  23. Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.

    Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

    Scientific reports　Vol. 12　No. 1　p. 351-351　2022/01/10　Research paper (scientific journal)

  24. Acceleration of amyloid fibril formation by multichannel sonochemical reactor

    Kentaro Noi, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi

    Japanese Journal of Applied Physics　2021/12/08　Research paper (scientific journal)

    Publisher: IOP Publishing

  25. Electrical Sensing of Au Nanoparticles Manipulated by an Optical Vortex

    Ryoji Nakatsuka, Syuhei Yanai, Kichitaro Nakajima, Kentaro Doi, Satoyuki Kawano

    The Journal of Physical Chemistry C　Vol. 125　No. 17　p. 9507-9515　2021/05/06　Research paper (scientific journal)

    Publisher: American Chemical Society ({ACS})

  26. Effect of hydrodynamic inter-particle interaction on the orbital motion of dielectric nanoparticles driven by an optical vortex

    Tetsuro Tsuji, Ryoji Nakatsuka, Kichitaro Nakajima, Kentaro Doi, Satoyuki Kawano

    Nanoscale　Vol. 12　No. 12　p. 6673-6690　2020/03/28　Research paper (scientific journal)

Misc. 11

  1. 超音波を利用した蛋白質アミロイド凝集誘導装置HANABI

    中島吉太郎, 山口圭一, 荻博次, 後藤祐児

    超音波テクノ　2021/09

  2. 超音波によるタンパク質凝集加速反応の周波数依存性

    中島吉太郎, 荻博次

    超音波テクノ　2019/09

  3. 超音波によるAβペプチドの凝集加速～キャビテーション気泡に着目した凝集加速モデルの提案～

    中島吉太郎, 足立寛太, 荻博次, 平尾雅彦, 後藤祐児

    超音波テクノ　2015/07

  4. ポリリン酸が引き起こすアミロイド線維形成機構

    山口圭一, 中島吉太郎, 後藤祐児

    月刊「細胞」　2021/08

  5. 全反射蛍光顕微鏡とQCMの融合によるアルツハイマー病ペプチドの凝集及び融解ダイナミクスの究明

    山田晃大朗, 中島吉太郎, 荻博次, 平尾雅彦

    超音波テクノ　Vol. 28　No. 6　p. 97-101　2016/11

    Publisher: 日本工業出版

  6. 1C12 Study on nucleation reaction of amyloid β peptide induced by ultrasonic cavitation

    NAKAJIMA Kichitaro, OGI Hirotsugu, HIRAO Masahiko, GOTO Yuji

    Vol. 2016　No. 28　p. "1C12-1"-"1C12-5"　2016/01/09

    Publisher: The Japan Society of Mechanical Engineers

  7. 2P2-1 Monitoring of dissociation dynamics of Alzheimer-disease aggregates by poly-phenol with TIRFM-QCM system

    Yamada Kotaro, Nakajima Kichitaro, Nishioka Daisuke, Ogi Hirotsugu, Goto Yuji, Hirao Masahiko

    Proceedings of Symposium on Ultrasonic Electronics　Vol. 36　p. "2P2-1-1"-"2P2-1-2"　2015/11/05

    Publisher: Steering committee of symposium on ultrasonic electronics

  8. 2P5-6 Study on aggregation reactions of amyloid β peptides induced by ultrasonic irradiation and stirring agitation

    Nakajima Kichitaro, Ogi Hirotsugu, Hirao Masahiko, Goto Yuji

    Proceedings of Symposium on Ultrasonic Electronics　Vol. 36　p. "2P5-6-1"-"2P5-6-2"　2015/11/05

    Publisher: Steering committee of symposium on ultrasonic electronics

  9. 3J2-4 Frequency dependence of ultrasonically accelerated fibrillation phenomenon of Alzheimer-disease peptides(Biomedical Ultrasound II)

    Adachi Kanta, Nakajima Kichitaro, Noi Kentaro, Yagi Hisashi, Goto Yuji, Ogi Hirotsugu, Hirao Masahiko

    Proceedings of Symposium on Ultrasonic Electronics　Vol. 35　p. 389-390　2014/12/03

    Publisher: Steering committee of symposium on ultrasonic electronics

  10. 2E3-2 Study on ultrasonically accelerated aggregation phenomenon of Aβ peptides based on cavitation-bubble dynamics(High Power Ultrasound, Sonochemistry)

    Nakajima Kichitaro, Adachi Kanta, Noi Kentaro, Yagi Hisashi, Goto Yuji, Ogi Hirotsugu, Hirao Masahiko

    Proceedings of Symposium on Ultrasonic Electronics　Vol. 35　p. 201-202　2014/12/03

    Publisher: Steering committee of symposium on ultrasonic electronics

  11. 2P5-9 Effect of glycerol on ultrasonically induced aggregation phenomenon of amyloid β peptides(Poster Session)

    Nakajima Kichitaro, Noi Kentaro, Ogi Hirotsugu, Yagi Hisashi, Goto Yuji, Hirao Masahiko

    Proceedings of Symposium on Ultrasonic Electronics　Vol. 34　p. 317-318　2013/11/20

    Publisher: Steering committee of symposium on ultrasonic electronics

Institutional Repository 10

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor

    Zhou Lianjie, Hajiri Touko, Nakajima Kichitaro, Aguirre César, Ikenaka Kensuke, Mochizuki Hideki, Yamaguchi Keiichi, Goto Yuji, Ogi Hirotsugu

    ACS Sensors　Vol. 8　No. 7　p. 2598-2608　2023/07/28

  2. Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

    Nakajima Kichitaro, Yamaguchi Keiichi, Noji Masahiro, Aguirre César, Ikenaka Kensuke, Mochizuki Hideki, Zhou Lianjie, Ogi Hirotsugu, Ito Toru, Narita Ichiei, Gejyo Fumitake, Naiki Hironobu, Yamamoto Suguru, Goto Yuji

    Nature Communications　Vol. 13　2022/10/03

  3. Development of HANABI, an ultrasonication-forced amyloid fibril inducer

    Goto Yuji, Nakajima Kichitaro, Yamaguchi Keiichi, So Masatomo, Ikenaka Kensuke, Mochizuki Hideki, Ogi Hirotsugu

    Neurochemistry International　Vol. 153　2022/02/01

  4. Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction

    Nakajima Kichitaro, Toda Hajime, Yamaguchi Keiichi, So Masatomo, Ikenaka Kensuke, Mochizuki Hideki, Goto Yuji, Ogi Hirotsugu

    ACS Chemical Neuroscience　Vol. 12　No. 18　p. 3456-3466　2021/09/15

  5. Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation

    Nakajima Kichitaro, Noi Kentaro, Yamaguchi Keiichi, So Masatomo, Ikenaka Kensuke, Mochizuki Hideki, Ogi Hirotsugu, Goto Yuji

    Ultrasonics Sonochemistry　Vol. 73　2021/03/03

  6. Time-Resolved Observation of Evolution of Amyloid-β Oligomer with Temporary Salt Crystals

    Nakajima Kichitaro, Yamazaki Tomoya, Kimura Yuki, So Masatomo, Goto Yuji, Ogi Hirotsugu

    Journal of Physical Chemistry Letters　Vol. 11　No. 15　p. 6176-6184　2020/07/20

  7. Optimized Ultrasonic Irradiation Finds Out Ultrastable Aβ₁₋₄₀ Oligomers

    Nakajima Kichitaro, So Masatomo, Takahashi Kazuma, Tagawa Yoh-ichi, Hirao Masahiko, Goto Yuji, Ogi Hirotsugu

    Journal of Physical Chemistry B　Vol. 121　No. 12　p. 2603-2613　2017/03/30

  8. Drastic acceleration of fibrillation of insulin by transient cavitation bubble

    Nakajima Kichitaro, Nishioka Daisuke, Hirao Masahiko, So Masatomo, Goto Yuji, Ogi Hirotsugu

    Ultrasonics Sonochemistry　Vol. 36　p. 206-211　2016/11/28

  9. Nucleus factory on cavitation bubble for amyloid β fibril

    Nakajima Kichitaro, Ogi Hirotsugu, Adachi Kanta, Noi Kentaro, Hirao Masahiko, Yagi Hisashi, Goto Yuji

    Vol. 6　2016/02

  10. 超音波によるアミロイドβペプチドの凝集加速現象の機構解明

    中島 吉太郎