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Neoself-antigens are the primary target for autoreactive T cells in human lupus.
Shunsuke Mori, Masako Kohyama, Yoshiaki Yasumizu, Asa Tada, Kaito Tanzawa, Tatsuya Shishido, Kazuki Kishida, Hui Jin, Masayuki Nishide, Shoji Kawada, Daisuke Motooka, Daisuke Okuzaki, Ryota Naito, Wataru Nakai, Teru Kanda, Takayuki Murata, Chikashi Terao, Koichiro Ohmura, Noriko Arase, Tomohiro Kurosaki, Manabu Fujimoto, Tadahiro Suenaga, Atsushi Kumanogoh, Shimon Sakaguchi, Yoshihiro Ogawa, Hisashi Arase
Cell Vol. 187 No. 21 p. 6071-6087 2024/10/17 Research paper (scientific journal)
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Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase
<I>Science Advances</I> Vol. 8 No. 9 2022/03/04 Research paper (scientific journal)
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An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
Yafei Liu, Wai Tuck Soh, Jun ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Takayuki Kato, Masato Okada, Daron M. Standley, Tatsuo Shioda, Hisashi Arase
<I>Cell</I> Vol. 184 No. 13 p. 3452-3466.e18 2021/06/24 Research paper (scientific journal)
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Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase
<I>Nature</I> Vol. 552 No. 7683 p. 101-105 2017 Research paper (scientific journal)
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Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2
Kouyuki Hirayasu, Fumiji Saito, Tadahiro Suenaga, Kyoko Shida, Noriko Arase, Keita Oikawa, Toshifumi Yamaoka, Hiroyuki Murota, Hiroji Chibana, Ichiro Nakagawa, Tomoko Kubori, Hiroki Nagai, Yuji Nakamaru, Ichiro Katayama, Marco Colonna, Hisashi Arase
<I>Nature Microbiology</I> Vol. 1 No. 6 p. 16054-16054 2016/04 Research paper (scientific journal)
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Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation
Jing Wang, Ikuo Shiratori, Junji Uehori, Masahito Ikawa, Hisashi Arase
Nature Immunology Vol. 14 No. 1 p. 34-40 2013/01 Research paper (scientific journal)
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PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B
Takeshi Satoh, Jun Arii, Tadahiro Suenaga, Jing Wang, Amane Kogure, Junji Uehori, Noriko Arase, Ikuo Shiratori, Shinya Tanaka, Yasushi Kawaguchi, Patricia G. Spear, Lewis L. Lanier, Hisashi Arase
Cell Vol. 132 No. 6 p. 935-944 2008/03/21 Research paper (scientific journal)
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Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity.
Ayumi Kuratani, Masaaki Okamoto, Kazuki Kishida, Daisuke Okuzaki, Miwa Sasai, Shimon Sakaguchi, Hisashi Arase, Masahiro Yamamoto
Science (New York, N.Y.) Vol. 386 No. 6724 2024/11/22 Research paper (scientific journal)
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Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2.
Yifan Li, Kouyuki Hirayasu, Gen Hasegawa, Yosei Tomita, Yuko Hashikawa, Ryosuke Hiwa, Hisashi Arase, Rikinari Hanayama
Frontiers in immunology Vol. 15 p. 1435236-1435236 2024/09/23 Research paper (scientific journal)
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Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study.
Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Masashi Deguchi, Takeshi Nagamatsu, Tomoyuki Fujii, Mikiya Nakatsuka, Gen Kobashi, Hisashi Arase, Hideto Yamada
Frontiers in immunology Vol. 15 p. 1445852-1445852 2024/09/01 Research paper (scientific journal)
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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Hui Jin, Hisashi Arase
Advances in Experimental Medicine and Biology Vol. 1444 p. 51-65 2024/03/12 Part of collection (book)
Publisher: Springer Nature Singapore
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Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies
Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley
Viruses Vol. 15 No. 12 p. 2421-2421 2023/12/13 Research paper (scientific journal)
Publisher: MDPI AG
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Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases.
Katsuhiko Yoneda, Yo Ueda, Kenji Tanimura, Hisashi Arase, Hideto Yamada, Jun Saegusa
Arthritis research & therapy Vol. 25 No. 1 p. 195-195 2023/10/06 Research paper (scientific journal)
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Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5.
Seisuke Kusano, Sho Ueda, Daisuke Oryoji, Aya Toyoumi, Akiko Hashimoto-Tane, Hiroyuki Kishi, Hiroshi Hamana, Atsushi Muraguchi, Hui Jin, Hisashi Arase, Hiroko Miyadera, Reiko Kishikawa, Yasunobu Yoshikai, Hisakata Yamada, Ken Yamamoto, Yasuharu Nishimura, Takashi Saito, Takehiko Sasazuki, Shigeyuki Yokoyama
International immunology Vol. 35 No. 9 p. 447-458 2023/09/05 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules.
Shanshan Zhang, Hideaki Tsuji, Hui Jin, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Masao Tanaka, Hisashi Arase, Koichiro Ohmura, Akio Morinobu
Rheumatology (Oxford, England) Vol. 62 No. 9 p. 3151-3155 2023/09/01 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
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An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Emiko Urano, Yumi Itoh, Tatsuya Suzuki, Takanori Sasaki, Jun-Ichi Kishikawa, Kanako Akamatsu, Yusuke Higuchi, Yusuke Sakai, Tomotaka Okamura, Shuya Mitoma, Fuminori Sugihara, Akira Takada, Mari Kimura, Shuto Nakao, Mika Hirose, Tadahiro Sasaki, Ritsuko Koketsu, Shunya Tsuji, Shota Yanagida, Tatsuo Shioda, Eiji Hara, Satoaki Matoba, Yoshiharu Matsuura, Yasunari Kanda, Hisashi Arase, Masato Okada, Junichi Takagi, Takayuki Kato, Atsushi Hoshino, Yasuhiro Yasutomi, Akatsuki Saito, Toru Okamoto
Science translational medicine Vol. 15 No. 711 2023/08/30 Research paper (scientific journal)
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Positive and negative regulation of the Fcγ receptor-stimulating activity of RNA-containing immune complexes by RNase.
Ryota Naito, Koichiro Ohmura, Shuhei Higuchi, Wataru Nakai, Masako Kohyama, Tsuneyo Mimori, Akio Morinobu, Hisashi Arase
JCI insight Vol. 8 No. 16 2023/08/22 Research paper (scientific journal)
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ネオセルフ:自己抗原/HLAクラスII分子複合体による新たな自己免疫疾患発症機構
金暉, 荒瀬尚
炎症と免疫 2023/08/01 Research paper (scientific journal)
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Anti-β2-glycoprotein I/HLA-DR antibody in infertility.
Yosuke Ono, Shinichiro Wada, Hajime Ota, Yoshiyuki Fukushi, Kenji Tanimura, Osamu Yoshino, Hisashi Arase, Hideto Yamada
Journal of reproductive immunology Vol. 158 p. 103955-103955 2023/08/01 Research paper (scientific journal)
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Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes
Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Hajime Ota, Shinichiro Wada, Masashi Deguchi, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Gen Kobashi, Hisashi Arase, Hideto Yamada
International Journal of Molecular Sciences Vol. 24 No. 13 2023/07/01 Research paper (scientific journal)
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自己抗原/HLAクラスⅡ分子複合体と自己免疫疾患
金暉, 荒瀬尚
実験医学 2023/04/01 Research paper (scientific journal)
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Extracellular transportation of α-synuclein by HLA class II molecules.
Tatsuhiko Ozono, Yasuyoshi Kimura, Tadahiro Suenaga, Goichi Beck, Jyunki Jinno, César Aguirre, Kensuke Ikenaka, Dimitri Krainc, Hideki Mochizuki, Hisashi Arase
Biochemical and biophysical research communications Vol. 644 p. 25-33 2023/02/12 Research paper (scientific journal)
Publisher: Elsevier BV
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SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.
Masako Kohyama, Tatsuya Suzuki, Wataru Nakai, Chikako Ono, Sumiko Matsuoka, Koichi Iwatani, Yafei Liu, Yusuke Sakai, Atsushi Nakagawa, Keisuke Tomii, Koichiro Ohmura, Masato Okada, Yoshiharu Matsuura, Shiro Ohshima, Yusuke Maeda, Toru Okamoto, Hisashi Arase
International immunology Vol. 35 No. 1 p. 43-52 2023/01/21 Research paper (scientific journal)
-
Neutralizing and enhancing antibodies against SARS-CoV-2.
Yafei Liu, Hisashi Arase
Inflammation and regeneration Vol. 42 No. 1 p. 58-58 2022/12/05 Research paper (scientific journal)
-
Landscape of infection enhancing antibodies in COVID-19 and healthy donors
Hendra S. Ismanto, Zichang Xu, Dianita S. Saputri, Jan Wilamowski, Songling Li, Dendi K. Nugraha, Yasuhiko Horiguchi, Masato Okada, Hisashi Arase, Daron M Standley
Computational and Structural Biotechnology Journal Vol. 20 p. 6033-6040 2022/11/04 Research paper (scientific journal)
Publisher: Elsevier BV
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A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease.
Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Science translational medicine Vol. 14 No. 661 2022/09/07 Research paper (scientific journal)
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免疫受容体LILRA2のANGPTL6認識機構(Molecular mechanism of ANGPTL6 recognition by immune activation receptor LILRA2)
Wang Jiaqi, Furukawa Atsushi, Yamazaki Rika, Hirayasu Kouyuki, Kadomatsu Tsuyoshi, Oike Yuichi, Arase Hisashi, Maenaka Katsumi
生物物理 Vol. 62 No. Suppl.1-2 p. S269-S269 2022/08
Publisher: (一社)日本生物物理学会
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Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
Peng Zhao, Yuanzhong Xu, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Qingchun Tong, Ningyan Zhang, Zhiqiang An
mAbs Vol. 14 No. 1 p. 2107971-2107971 2022/08/01 Research paper (scientific journal)
Publisher: Informa UK Limited
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SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies.
Kevin W Ng, Nikhil Faulkner, Katja Finsterbusch, Mary Wu, Ruth Harvey, Saira Hussain, Maria Greco, Yafei Liu, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J Gamblin, Peter Cherepanov, John McCauley, Rodney Daniels, Michael Howell, Hisashi Arase, Andreas Wack, David L V Bauer, George Kassiotis
Science translational medicine Vol. 14 No. 655 2022/07/27 Research paper (scientific journal)
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Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
Tadahiro Suenaga, Yasuko Mori, Tatsuo Suzutani, Hisashi Arase
<B>Biochemical and Biophysical Research Communications</B> Vol. 613 p. 41-46 2022/07/12 Research paper (scientific journal)
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LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Molecular neurodegeneration Vol. 17 No. 1 p. 44-44 2022/06/18 Research paper (scientific journal)
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Mechanisms for Host Immune Evasion Mediated by Plasmodium falciparum-Infected Erythrocyte Surface Antigens.
Akihito Sakoguchi, Hisashi Arase
Frontiers in immunology Vol. 13 p. 901864-901864 2022/06/01 Research paper (scientific journal)
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Preclinical study of a DNA vaccine targeting SARS-CoV-2.
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Ritsuko Kubota-Koketsu, Tatsuo Shioda, Chikako Ono, Yoshiharu Matsuura, Hisashi Arase, Shota Yoshida, Ryo Nakamaru, Nan Ju, Ryoko Ide, Akiko Tenma, Sotaro Kawabata, Takako Ehara, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Takao Komatsuno, Yoshimi Saito, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami
Current research in translational medicine Vol. 70 No. 4 p. 103348-103348 2022/04/20 Research paper (scientific journal)
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Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
Tadahiro Suenaga, Yasuko Mori, Tatsuo Suzutani, Hisashi Arase
<I>Biochemical and Biophysical Research Communications</I> Vol. 607 p. 67-72 2022/03/23 Research paper (scientific journal)
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Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells.
Yoshitaka Adachi, Toshiyasu Sakai, Seitaro Terakura, Takashi Shiina, Shingo Suzuki, Hiroshi Hamana, Hiroyuki Kishi, Takehiko Sasazuki, Hisashi Arase, Ryo Hanajiri, Tatsunori Goto, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi
International journal of hematology Vol. 115 No. 3 p. 371-381 2022/03/01 Research paper (scientific journal)
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Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor-induced bullous pemphigoid.
Chigusa Yamashita, Noriko Arase, Shuhei Higuchi, Hisashi Arase, Junichi Takagi, Satoshi Nojima, Atsushi Tanemura, Manabu Fujimoto
JAAD case reports Vol. 20 p. 65-68 2022/02/01 Research paper (scientific journal)
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A Case of Pretibial Epidermolysis Bullosa with Novel Mutations of the COL7A1 Gene.
Yuri Shimizu, Yorihisa Kotobuki, Noriko Arase, Hisashi Arase, Ichiro Katayama, Manabu Fujimoto
Annals of dermatology Vol. 34 No. 1 p. 81-83 2022/02/01 Research paper (scientific journal)
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The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
Izumi Kimura, Yusuke Kosugi, Jiaqi Wu, Jiri Zahradnik, Daichi Yamasoba, Erika P Butlertanaka, Yuri L Tanaka, Keiya Uriu, Yafei Liu, Nanami Morizako, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kenzo Tokunaga, Takamasa Ueno, Akifumi Takaori-Kondo, Gideon Schreiber, Hisashi Arase, Chihiro Motozono, Akatsuki Saito, So Nakagawa, Kei Sato
Cell reports Vol. 38 No. 2 p. 110218-110218 2022/01/11 Research paper (scientific journal)
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High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD).
Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M Standley, Tatsusada Okuno, Hideki Mochizuki
Scientific reports Vol. 12 No. 1 p. 106-106 2022/01/07 Research paper (scientific journal)
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Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.
Noriko Arase, Hideaki Tsuji, Hyota Takamatsu, Hui Jin, Hachiro Konaka, Yasuhito Hamaguchi, Kyoko Tonomura, Yorihisa Kotobuki, Ikuko Ueda-Hayakawa, Sumiko Matsuoka, Toru Hirano, Hideki Yorifuji, Hiroyuki Murota, Koichiro Ohmura, Ran Nakashima, Tomoharu Sato, Atsushi Kumanogoh, Ichiro Katayama, Hisashi Arase, Manabu Fujimoto
Journal of autoimmunity Vol. 126 p. 102774-102774 2022/01/01 Research paper (scientific journal)
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Anti-Double-Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles.
Hideaki Tsuji, Koichiro Ohmura, Hui Jin, Ryota Naito, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Shuhei Sakakibara, Yuta Kochi, Yukinori Okada, Kazuhiko Yamamoto, Hitoshi Kikutani, Akio Morinobu, Tsuneyo Mimori, Hisashi Arase
<I>Arthritis & rheumatology</I> Vol. 74 No. 1 p. 105-111 2022/01 Research paper (scientific journal)
Publisher: Wiley
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Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.
Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki
The Journal of experimental medicine Vol. 218 No. 12 2021/12/06 Research paper (scientific journal)
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SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals
Shota Yoshida, Chikako Ono, Hiroki Hayashi, Shinya Fukumoto, Satoshi Shiraishi, Kazunori Tomono, Hisashi Arase, Yoshiharu Matsuura, Hironori Nakagami
Scientific Reports Vol. 11 No. 1 2021/12/01 Research paper (scientific journal)
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The major histocompatibility complex: new insights from old molecules into the pathogenesis of autoimmunity.
Hisashi Arase
International immunology Vol. 33 No. 12 p. 641-645 2021/11/25 Research paper (scientific journal)
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LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis.
Guojin Wu, Yixiang Xu, Robbie D Schultz, Heyu Chen, Jingjing Xie, Mi Deng, Xiaoye Liu, Xun Gui, Samuel John, Zhigang Lu, Hisashi Arase, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Nature cancer Vol. 2 No. 11 p. 1170-1184 2021/11/01 Research paper (scientific journal)
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The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines
Yafei Liu, Noriko Arase, Jun-ichi Kishikawa, Mika Hirose, Songling Li, Asa Tada, Sumiko Matsuoka, Akemi Arakawa, Kanako Akamatsu, Chikako Ono, Hui Jin, Kazuki Kishida, Wataru Nakai, Masako Kohyama, Atsushi Nakagawa, Yoshiaki Yamagishi, Hironori Nakagami, Atsushi Kumanogoh, Yoshiharu Matsuura, Daron M. Standley, Takayuki Kato, Masato Okada, Manabu Fujimoto, Hisashi Arase
2021/08/23
Publisher: Cold Spring Harbor Laboratory
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Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice
Mei Tzu Su, Masanori Inui, Yi Li Wong, Maika Takahashi, Akiko Sugahara-Tobinai, Karin Ono, Shotaro Miyamoto, Keiichi Murakami, Ari Itoh-Nakadai, Dai Kezuka, So Itoi, Shota Endo, Kouyuki Hirayasu, Hisashi Arase, Toshiyuki Takai
International Immunology Vol. 33 No. 8 p. 447-458 2021/08/01 Research paper (scientific journal)
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A Novel Autoantibody against β2-Glycoprotein I/HLA Class II Complexes in Antiphospholipid Syndrome
Kenji Tanimura, Yuki Sasagawa, Masashi Deguchi, Noriko Arase, Hisashi Arase, Hideto Yamada
Antiphospholipid Syndrome - Recent Advances in Basic and Clinical Aspects [Working Title] 2021/04/23 Part of collection (book)
Publisher: IntechOpen
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TRIM28 expression on dendritic cells prevents excessive T cell priming by silencing endogenous retrovirus
Shunsuke Chikuma, Soichiro Yamanaka, So Nakagawa, Mahoko Takahashi Ueda, Hodaka Hayabuchi, Yukiko Tokifuji, Masashi Kanayama, Tadashi Okamura, Hisashi Arase, Akihiko Yoshimura
Journal of Immunology Vol. 206 No. 7 p. 1529-1539 2021/04/01 Research paper (scientific journal)
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Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2
Akihito Sakoguchi, Fumiji Saito, Kouyuki Hirayasu, Kyoko Shida, Sumiko Matsuoka, Sawako Itagaki, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Shiroh Iwanaga, Toshihiro Horii, Hisashi Arase
<I>Biochemical and Biophysical Research Communications</I> Vol. 548 p. 167-173 2021/04 Research paper (scientific journal)
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【免疫系の暴走 サイトカインストーム 多様な疾患で生じる全身性の炎症反応その共通機構から病態を理解する】ウイルス感染による免疫応答とサイトカインストーム
香山 雅子, 荒瀬 尚
実験医学 Vol. 39 No. 4 p. 524-529 2021/03
Publisher: (株)羊土社
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免疫活性化受容体LILRA2のANGPTL6認識機構の解明(The understanding of binding mechanism of LILRA2 and ANGPTL6)
王 嘉き, 古川 敦, 山崎 莉佳, 平安 恒幸, 門松 毅, 尾池 雄一, 荒瀬 尚, 前仲 勝実
日本薬学会年会要旨集 Vol. 141年会 p. 28P01-105S 2021/03
Publisher: (公社)日本薬学会
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A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice
Yushi Matsumoto, Kazuki Kishida, Maki Matsumoto, Sumiko Matsuoka, Masako Kohyama, Tadahiro Suenaga, Hisashi Arase
<I>Biochemical and Biophysical Research Communications</I> Vol. 534 p. 680-686 2021/01/01 Research paper (scientific journal)
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Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor α (PILRα)
Shigekazu Tabata, Kimiko Kuroki, Nobuo Maita, Jing Wang, Ikuo Shiratori, Hisashi Arase, Daisuke Kohda, Katsumi Maenaka
Acta Crystallographica Section F: Structural Biology and Crystallization Communications Vol. 64 No. 1 p. 44-46 2021/01 Research paper (scientific journal)
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新たなネフリンタンパク質とHLAクラスIIの複合体 ステロイド感受性ネフローゼ症候群発症の新たなメカニズム(Novel nephrin protein/HLA classII complexes: A new mechanism of steroid sensitive nephrotic syndrome)
堀之内 智子, 長野 智那, 山村 智彦, 香山 雅子, 野津 寛大, 飯島 一誠, 荒瀬 尚
日本小児腎臓病学会雑誌 Vol. 33 No. 1Suppl. p. 88-88 2020/12
Publisher: (一社)日本小児腎臓病学会
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Structural basis for RIFIN-mediated activation of LILRB1 in malaria
Thomas E. Harrison, Alexander M. Mørch, James H. Felce, Akihito Sakoguchi, Adam J. Reid, Hisashi Arase, Michael L. Dustin, Matthew K. Higgins
<I>Nature</I> Vol. 587 No. 7833 p. 309-312 2020/11/12 Research paper (scientific journal)
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The β <inf>2</inf>-Glycoprotein I/HLA–DR Complex As a Major Autoantibody Target in Obstetric Antiphospholipid Syndrome
Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada
Arthritis and Rheumatology Vol. 72 No. 11 p. 1882-1891 2020/11/01 Research paper (scientific journal)
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LILRA2のリガンド認識機構の解明
古川 敦, 山崎 莉佳, Jiaqi Wang, 平安 恒幸, 湯本 航平, 福原 秀雄, 荒瀬 尚, 前仲 勝実
日本生化学会大会プログラム・講演要旨集 Vol. 93回 p. [2Z13-659)] 2020/09
Publisher: (公社)日本生化学会
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Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells
Heyu Chen, Yuanzhi Chen, Mi Deng, Samuel John, Xun Gui, Ankit Kansagra, Weina Chen, Jaehyup Kim, Cheryl Lewis, Guojin Wu, Jingjing Xie, Lingbo Zhang, Ryan Huang, Xiaoye Liu, Hisashi Arase, Yang Huang, Hai Yu, Wenxin Luo, Ningshao Xia, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Journal for ImmunoTherapy of Cancer Vol. 8 No. 2 2020/08/07 Research paper (scientific journal)
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Molecular mechanism of the recognition of bacterially cleaved immunoglobulin by the immune regulatory receptor LILRA2
Rika Yamazaki, Atsushi Furukawa, Kouyuki Hirayasu, Kohei Yumoto, Hideo Fukuhara, Hisashi Arase, Katsumi Maenaka
Journal of Biological Chemistry Vol. 295 No. 28 p. 9531-9541 2020/07/10 Research paper (scientific journal)
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Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild-type KIT patients
Noriko Arase, Mari Wataya-Kaneda, Hiroyuki Murota, Yukinobu Nakagawa, Toshifumi Yamaoka, Saori Itoi-Ochi, Kouyuki Hirayasu, Hisashi Arase, Manabu Fujimoto, Ichiro Katayama
Journal of Dermatology Vol. 47 No. 4 p. 426-429 2020/04 Research paper (scientific journal)
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Antigen-driven selection of antibodies against SSA, SSB and the centromere complex', including a novel antigen, MIS12 complex, in human salivary glands
Masaru Takeshita, Katsuya Suzuki, Yukari Kaneda, Humitsugu Yamane, Kazuhiro Ikeura, Hidekazu Sato, Shin Kato, Kazuyuki Tsunoda, Hisashi Arase, Tsutomu Takeuchi
Annals of the Rheumatic Diseases Vol. 79 No. 1 p. 150-158 2020/01/01 Research paper (scientific journal)
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Case of epidermolytic ichthyosis with impairment of pulmonary function and exacerbated skin manifestations in a late middle-aged adult
Aya Maekawa, Noriko Arase, Katsuto Tamai, Toshifumi Nomura, Eiji Kiyohara, Mari Wataya-Kaneda, Hisashi Arase, Ichiro Katayama, Manabu Fujimoto
Journal of Dermatology Vol. 46 No. 12 p. e480-e482 2019/12/01
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Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma
Noriko Arase, Atsushi Tanemura, Hui Jin, Megumi Nishioka, Yumi Aoyama, Naoki Oiso, Kayoko Matsunaga, Tamio Suzuki, Chikako Nishigori, Tatsuyoshi Kawamura, Tadamichi Shimizu, Akiko Ito, Kazuyoshi Fukai, Yuko Abe, Lingli Yang, Daisuke Tsuruta, Keiko Takeoka, Yoshinori Iwatani, Yoh Hidaka, Makoto Nishida, Keiko Yamauchi-Takihara, Hisashi Arase, Manabu Fujimoto, Ichiro Katayama
Journal of Dermatological Science Vol. 95 No. 2 p. 80-83 2019/08
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FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules
Yuta Shimizu, Masako Kohyama, Hideki Yorifuji, Hui Jin, Noriko Arase, Tadahiro Suenaga, Hisashi Arase
International Immunology Vol. 31 No. 5 p. 303-314 2019/04 Research paper (scientific journal)
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Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain
Hideki Yorifuji, Noriko Arase, Masako Kohyama, Toru Hirano, Tadahiro Suenaga, Atsushi Kumanogoh, Hisashi Arase
<I>Biochemical and Biophysical Research Communications</I> Vol. 511 No. 4 p. 862-868 2019/04 Research paper (scientific journal)
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Invariant chain p41 mediates production of soluble MHC class II molecules
Tatsuya Shishido, Masako Kohyama, Wataru Nakai, Maki Matsumoto, Haruhiko Miyata, Tadahiro Suenaga, Hisashi Arase
<I>Biochemical and Biophysical Research Communications</I> Vol. 509 No. 1 p. 216-221 2019/01/29 Research paper (scientific journal)
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Glycans in infection and immunity
Takashi Suzuki, Masatoshi Okamatsu, Yoshihiro Sakoda, Taroh Kinoshita, Takane Katayama, Hiroshi Kiyono, Yoshiyuki Goto, Kaoru Takegawa, Naoaki Yokoyama, Yukari Fujimoto, Takashi Angata, Katsuki Ohtani, Nobutaka Wakamiya, Hisashi Arase, Shoko Nishihara, Yasuo Suda
Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG) p. 227-257 2019/01/01 Part of collection (book)
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Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity
Hui Ming Chen, William van der Touw, Yuan Shuo Wang, Kyeongah Kang, Sunny Mai, Jilu Zhang, Dayanira Alsina-Beauchamp, James A. Duty, Sathish Kumar Mungamuri, Bin Zhang, Thomas Moran, Richard Flavell, Stuart Aaronson, Hong Ming Hu, Hisashi Arase, Suresh Ramanathan, Raja Flores, Ping Ying Pan, Shu Hsia Chen
Journal of Clinical Investigation Vol. 128 No. 12 p. 5647-5662 2018/12/03 Research paper (scientific journal)
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LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng, Xun Gui, Jaehyup Kim, Li Xie, Weina Chen, Zunling Li, Licai He, Yuanzhi Chen, Heyu Chen, Weiguang Luo, Zhigang Lu, Jingjing Xie, Hywyn Churchill, Yixiang Xu, Zhan Zhou, Guojin Wu, Chenyi Yu, Samuel John, Kouyuki Hirayasu, Nam Nguyen, Xiaoye Liu, Fangfang Huang, Leike Li, Hui Deng, Haidong Tang, Ali H. Sadek, Lingbo Zhang, Tao Huang, Yizhou Zou, Benjamin Chen, Hong Zhu, Hisashi Arase, Ningshao Xia, Youxing Jiang, Robert Collins, M. James You, Jade Homsi, Nisha Unni, Cheryl Lewis, Guo Qiang Chen, Yang Xin Fu, X. Charlene Liao, Zhiqiang An, Junke Zheng, Ningyan Zhang, Cheng Cheng Zhang
Nature Vol. 562 No. 7728 p. 605-609 2018/10/25 Research paper (scientific journal)
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Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles
Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda
Proceedings of the National Academy of Sciences of the United States of America Vol. 115 No. 33 p. 8418-8423 2018/08/14 Research paper (scientific journal)
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Heightened BRAF and BRAF pseudogene expression levels in two Japanese patients with Erdheim-Chester disease.
Murakami Yukako, Wataya-Kaneda Mari, Kitayama Kazuko, Arase Noriko, Murota Hiroyuki, Hirayasu Kouyuki, Arase Hisashi, Katayama, Ichiro
Journal of Cutaneous Immunology and Allergy Vol. 1 No. 1 p. 16-22 2018/04 Research paper (scientific journal)
Publisher: Wiley
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Novel autoantibody against the β2-glycoprotein I/human leucocyte antigen–DR complex in patients with refractory cutaneous ulcers
N. Arase, K. Tanimura, H. Jin, T. Yamaoka, M. Kishibe, M. Nishioka, E. Kiyohara, M. Tani, S. Matsuoka, K. Ohmura, K. Takasugi, T. Yamamoto, H. Murota, H. Arase, I. Katayama
British Journal of Dermatology Vol. 178 No. 1 p. 272-275 2018/01 Research paper (scientific journal)
Publisher: Blackwell Publishing Ltd
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Leukocyte Immunoglobulin-Like Receptor (LILR).
Hirayasu K, Arase H
Encyclopedia of Signaling Molecules. 2nd Edition. Springer. p. 2854-2861 2018/01
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Novel autoantibody against the β2-glycoprotein I/human leucocyte antigen–DR complex in patients with refractory cutaneous ulcers
N. Arase, K. Tanimura, H. Jin, T. Yamaoka, M. Kishibe, M. Nishioka, E. Kiyohara, M. Tani, S. Matsuoka, K. Ohmura, K. Takasugi, T. Yamamoto, H. Murota, H. Arase, I. Katayama
British Journal of Dermatology Vol. 178 No. 1 p. 272-275 2018/01/01
Publisher: Blackwell Publishing Ltd
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Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor
X. Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura, X. Kimiko Kuroki, Hisanori Nambu, X. Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, X. Katsumi Maenaka
Journal of Biological Chemistry Vol. 292 No. 51 p. 21128-21136 2017/12/22 Research paper (scientific journal)
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【免疫学の新展開と呼吸器疾患】基礎医学とのダイアローグ MHCクラスIIの再発見 ネオ・セルフ ミスフォールドタンパク質/MHCクラスII分子複合体による新たな自己免疫疾患発症機構
辻 英輝, 荒瀬 尚
THE LUNG-perspectives Vol. 25 No. 4 p. 397-401 2017/12
Publisher: (株)メディカルレビュー社
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Myeloperoxidase/HLA Class II Complexes Recognized by Autoantibodies in Microscopic Polyangiitis
Ryosuke Hiwa, Koichiro Ohmura, Noriko Arase, Hui Jin, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Chikashi Terao, Tatsuya Atsumi, Hirotsugu Iwatani, Tsuneyo Mimori, Hisashi Arase
<B>Arthritis and Rheumatology</B> Vol. 69 No. 10 p. 2069-2080 2017/10 Research paper (scientific journal)
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The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells
Hong Sheng Dai, Nathaniel Griffin, Chelsea Bolyard, Hsiaoyin Charlene Mao, Jianying Zhang, Timothy P. Cripe, Tadahiro Suenaga, Hisashi Arase, Ichiro Nakano, E. A. Chiocca, Balveen Kaur, Jianhua Yu, Michael A. Caligiuri
Immunity Vol. 47 No. 1 p. 159-170.e10 2017/07/18 Research paper (scientific journal)
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The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase
Noriko Arase, Lingli Yang, Atsushi Tanemura, Fei Yang, Tadahiro Suenaga, Hisashi Arase, Ichiro Katayama
Journal of Dermatological Science Vol. 83 No. 2 p. 157-159 2016/08/01
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Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα
Masako Kohyama, Sumiko Matsuoka, Kyoko Shida, Fuminori Sugihara, Taiki Aoshi, Kazuki Kishida, Ken J. Ishii, Hisashi Arase
European Journal of Immunology Vol. 46 No. 5 p. 1214-1223 2016/05/01 Research paper (scientific journal)
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Establishment of a therapeutic anti-pan HLA-class II monoclonal antibody that directly induces lymphoma cell death via large pore formation
Shuji Matsuoka, Yasuyuki Ishii, Atsuhito Nakao, Masaaki Abe, Naomi Ohtsuji, Shuji Momose, Hui Jin, Hisashi Arase, Koichi Sugimoto, Yusuke Nakauchi, Hiroshi Masutani, Michiyuki Maeda, Hideo Yagita, Norio Komatsu, Okio Hino
PLoS ONE Vol. 11 No. 3 2016/03/01 Research paper (scientific journal)
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Misfolded proteins complexed with HLA class II molecules are involved in autoimmune diseases as a target for autoantibodies
Noriko Arase, Hisashi Arase
Nihon rinsho. Japanese journal of clinical medicine Vol. 74 No. 2 p. 359-368 2016/02/01
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6学会合同シンポジウム4 β2-グリコプロテインI/HLA class II複合体は抗リン脂質抗体症候群の標的抗原である
谷村 憲司, 出口 雅士, 蝦名 康彦, 渥美 達也, 山田 秀人, 荒瀬 尚
日本臨床免疫学会会誌 Vol. 39 No. 4 p. 306-306 2016
Publisher: 日本臨床免疫学会
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Misfolded proteins complexed with MHC class II molecules are targets for autoantibodies
Ryosuke Hiwa, Hisashi Arase
Japanese Journal of Clinical Immunology Vol. 39 No. 1 p. 78-83 2016 Research paper (scientific journal)
Publisher: Japan Society for Clinical Immunology
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Rapid screening by cell-based fusion assay for identifying novel antivirals of glycoprotein B-mediated herpes simplex virus type 1 infection
Naoyoshi Maeda, Atsushi Furukawa, Kosuke Kakita, Masahiro Anada, Shunichi Hashimoto, Shigeki Matsunaga, Kimiko Kuroki, Toyoyuki Ose, Akihisa Kato, Jun Arii, Yasushi Kawaguchi, Hisashi Arase, Katsumi Maenaka
Biological and Pharmaceutical Bulletin Vol. 39 No. 11 p. 1897-1902 2016 Research paper (scientific journal)
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Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases
Hisashi Arase
Advances in Immunology Vol. 129 p. 1-23 2016 Part of collection (book)
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Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targeted by autoantibodies
Hisashi Arase
Seikagaku. The Journal of Japanese Biochemical Society Vol. 87 No. 6 p. 785-788 2015/12/01
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Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations
Kouyuki Hirayasu, Hisashi Arase
Journal of Human Genetics Vol. 60 No. 11 p. 703-708 2015/11/01
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Sialic acids on varicella-zoster virus glycoprotein B are required for cell-cell fusion
Tadahiro Suenaga, Maki Matsumoto, Fuminori Arisawa, Masako Kohyama, Kouyuki Hirayasu, Yasuko Mori, Hisashi Arase
Journal of Biological Chemistry Vol. 290 No. 32 p. 19833-19843 2015/08/07 Research paper (scientific journal)
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Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases
Noriko Arase, Hisashi Arase
Journal of Biochemistry Vol. 158 No. 5 p. 367-372 2015/08/02
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Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration
Richard L. Watson, Jochen Buck, Lonny R. Levin, Ryan C. Winger, Jing Wang, Hisashi Arase, William A. Muller
Journal of Experimental Medicine Vol. 212 No. 7 p. 1021-1041 2015/06/29 Research paper (scientific journal)
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Negative regulation of DSS-induced experimental colitis by PILRa
Kazuki Kishida, Masako Kohyama, Yosuke Kurashima, Yuta Kogure, Jing Wang, Kouyuki Hirayasu, Tadahiro Suenaga, Hiroshi Kiyono, Jun Kunisawa, Hisashi Arase
International Immunology Vol. 27 No. 6 p. 307-314 2015/06/01 Research paper (scientific journal)
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Viral interactions with glycans
Tadahiro Suenaga, Hisashi Arase
Glycoscience: Biology and Medicine p. 785-794 2015/01/01 Part of collection (book)
Publisher: Springer Japan
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β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome
Kenji Tanimura, Hui Jin, Tadahiro Suenaga, Satoko Morikami, Noriko Arase, Kazuki Kishida, Kouyuki Hirayasu, Masako Kohyama, Yasuhiko Ebina, Shinsuke Yasuda, Tetsuya Horita, Kiyoshi Takasugi, Koichiro Ohmura, Ken Yamamoto, Ichiro Katayama, Takehiko Sasazuki, Lewis L. Lanier, Tatsuya Atsumi, Hideto Yamada, Hisashi Arase
Blood Vol. 125 No. 18 p. 2835-2844 2015 Research paper (scientific journal)
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Engineering large viral DNA genomes using the CRISPR-Cas9 system
Tadahiro Suenaga, Masako Kohyama, Kouyuki Hirayasu, Hisashi Arase
<B>Microbiology and Immunology</B> Vol. 58 No. 9 p. 513-522 2014/09 Research paper (scientific journal)
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A motif in LILRB2 critical for Angptl2 binding and activation
Mi Deng, Zhigang Lu, Junke Zheng, Xuan Wan, Xiaoli Chen, Kouyuki Hirayasu, Hanzi Sun, Yeeling Lam, Liping Chen, Qihui Wang, Chun Song, Niu Huang, George F. Gao, Youxing Jiang, Hisashi Arase, Cheng Cheng Zhang
Blood Vol. 124 No. 6 p. 924-935 2014/08/07 Research paper (scientific journal)
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Regulation of immune responses by neutrophils
Jing Wang, Hisashi Arase
Annals of the New York Academy of Sciences Vol. 1319 No. 1 p. 66-81 2014/06 Research paper (scientific journal)
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Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
Malay Haldar, Masako Kohyama, Alex Yick Lun So, Wumesh Kc, Xiaodi Wu, Carlos G. Briseño, Ansuman T. Satpathy, Nicole M. Kretzer, Hisashi Arase, Namakkal S. Rajasekaran, Li Wang, Takeshi Egawa, Kazuhiko Igarashi, David Baltimore, Theresa L. Murphy, Kenneth M. Murphy
<B>Cell</B> Vol. 156 No. 6 p. 1223-1234 2014/03/13 Research paper (scientific journal)
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Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility
Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Kenji Tanimura, Sumiko Matsuoka, Kosuke Ebina, Kenrin Shi, Noriko Toyama-Sorimachi, Shinsuke Yasuda, Tetsuya Horita, Ryosuke Hiwa, Kiyoshi Takasugi, Koichiro Ohmura, Hideki Yoshikawa, Takashi Saito, Tatsuya Atsumi, Takehiko Sasazuki, Ichiro Katayama, Lewis L. Lanier, Hisashi Arase
<B>Proc. Natl. Acad. Sci. USA</B> Vol. 111 No. 10 p. 3787-3792 2014/03/11 Research paper (scientific journal)
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A new mechanism of autoantibody production: Antigen presentation of misfolded protein by MHC class II
Koichiro Ohmura, Ryosuke Hiwa, Hisashi Arase
Japanese Journal of Clinical Immunology Vol. 37 No. 6 p. 462-467 2014 Research paper (scientific journal)
Publisher: Japan Society for Clinical Immunology
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Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα
Kimiko Kuroki, Jing Wang, Toyoyuki Ose, Munechika Yamaguchi, Shigekazu Tabata, Nobuo Maita, Seiko Nakamura, Mizuho Kajikawa, Amane Kogure, Takeshi Satoh, Hisashi Arase, Katsumi Maenaka
Proceedings of the National Academy of Sciences of the United States of America Vol. 111 No. 24 p. 8877-8882 2014 Research paper (scientific journal)
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Us3 Kinase Encoded by Herpes Simplex Virus 1 Mediates Downregulation of Cell Surface Major Histocompatibility Complex Class I and Evasion of CD8+ T Cells
Takahiko Imai, Naoto Koyanagi, Ryo Ogawa, Keiko Shindo, Tadahiro Suenaga, Ayuko Sato, Jun Arii, Akihisa Kato, Hiroshi Kiyono, Hisashi Arase, Yasushi Kawaguchi
PLoS ONE Vol. 8 No. 8 2013/08/12 Research paper (scientific journal)
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CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit
N. Arase, M. Wataya-Kaneda, N. Oiso, H. Arase, I. Katayama
British Journal of Dermatology Vol. 169 No. 1 p. 201-204 2013/07 Research paper (scientific journal)
Publisher: Blackwell Publishing Ltd
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Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules
Yan Jiang, Noriko Arase, Masako Kohyama, Kouyuki Hirayasu, Tadahiro Suenaga, Hui Jin, Maki Matsumoto, Kyoko Shida, Lewis L. Lanier, Takashi Saito, Hisashi Arase
International Immunology Vol. 25 No. 4 p. 235-246 2013/04 Research paper (scientific journal)
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Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis
Toshiyuki Minami, Takashi Kijima, Satoshi Kohmo, Hisashi Arase, Yasushi Otani, Izumi Nagatomo, Ryo Takahashi, Kotaro Miyake, Masayoshi Higashiguchi, Osamu Morimura, Shoichi Ihara, Kazuyuki Tsujino, Haruhiko Hirata, Koji Inoue, Yoshito Takeda, Hiroshi Kida, Isao Tachibana, Atsushi Kumanogoh
Scientific Reports Vol. 3 p. 2669-2669 2013 Research paper (scientific journal)
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Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion
Yuki Tanaka, Tadahiro Suenaga, Misako Matsumoto, Tsukasa Seya, Hisashi Arase
<B>Journal of Virology</B> Vol. 87 No. 19 p. 10900-10903 2013 Research paper (scientific journal)
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Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis
Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P. Tripathi, Yi An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogoh
Cancer Research Vol. 72 No. 12 p. 2990-2999 2012/06/15 Research paper (scientific journal)
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The development of colitogenic CD4 + T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis
Osamu Yamaji, Takashi Nagaishi, Teruji Totsuka, Michio Onizawa, Masahiro Suzuki, Naoto Tsuge, Atsuhiko Hasegawa, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Hisashi Arase, Takanori Kanai, Mamoru Watanabe
Journal of Immunology Vol. 188 No. 6 p. 2524-2536 2012/03/15 Research paper (scientific journal)
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Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA
Kouyuki Hirayasu, Jun Ohashi, Koichi Kashiwase, Hathairad Hananantachai, Izumi Naka, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Peter Parham, Hisashi Arase, Katsushi Tokunaga, Jintana Patarapotikul, Toshio Yabe
PLoS Pathogens Vol. 8 No. 3 2012/03 Research paper (scientific journal)
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PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues
Amane Kogure, Ikuo Shiratori, Jing Wang, Lewis L. Lanier, Hisashi Arase
Biochemical and Biophysical Research Communications Vol. 405 No. 3 p. 428-433 2011/02/18 Research paper (scientific journal)
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Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
Jun Arii, Hideo Goto, Tadahiro Suenaga, Masaaki Oyama, Hiroko Kozuka-Hata, Takahiko Imai, Atsuko Minowa, Hiroomi Akashi, Hisashi Arase, Yoshihiro Kawaoka, Yasushi Kawaguchi
Nature Vol. 467 No. 7317 p. 859-862 2010/10/14 Research paper (scientific journal)
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A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor α (PILRα) abrogates PILRα-dependent viral entry and reduces pathogenesis
Jun Arii, Jing Wang, Tomomi Morimoto, Tadahiro Suenaga, Hiroomi Akashi, Hisashi Arase, Yasushi Kawaguchi
Journal of Virology Vol. 84 No. 20 p. 10773-10783 2010/10 Research paper (scientific journal)
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Binding and uptake of H-ferritin are mediated by human transferrin receptor-1
Li Li, Celia J. Fang, James C. Ryan, Eréne C. Niemi, José A. Lebrón, Pamela J. Björkman, Hisashi Arase, Frank M. Torti, Suzy V. Torti, Mary C. Nakamura, William E. Seaman
<B>Proc. Natl. Acad. Sci. USA</B> Vol. 107 No. 8 p. 3505-3510 2010/02/23 Research paper (scientific journal)
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Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
Tadahiro Suenaga, Takeshi Satoh, Pranee Somboonthum, Yasushi Kawaguchi, Yasuko Mori, Hisashi Arase
<B>Proc. Natl. Acad. Sci. USA</B> Vol. 107 No. 2 p. 866-871 2010 Research paper (scientific journal)
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Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor α depends on specific sialylated O-linked glycans on gB
Jing Wang, Qing Fan, Takeshi Satoh, Jun Arii, Lewis L. Lanier, Patricia G. Spear, Yasushi Kawaguchi, Hisashi Arase
Journal of Virology Vol. 83 No. 24 p. 13042-13045 2009/12 Research paper (scientific journal)
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Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed
Qing Fan, Erick Lin, Takeshi Satoh, Hisashi Arase, Patricia G. Spear
Journal of Virology Vol. 83 No. 15 p. 7384-7390 2009/08 Research paper (scientific journal)
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[Novel mechanism of herpes simplex virus type-1 infection].
Takeshi Satoh, Hisashi Arase
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 54 No. 8 Suppl p. 961-966 2009/06
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Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation
Makiko Toma-Hirano, Sahori Namiki, Yasue Shibata, Koji Ishida, Hisashi Arase, Shoichiro Miyatake, Ken Ichi Arai, Yumiko Kamogawa-Schifter
European Journal of Immunology Vol. 39 No. 5 p. 1344-1352 2009/05 Research paper (scientific journal)
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Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor α
Jun Arii, Masashi Uema, Tomomi Morimoto, Hiroshi Sagara, Hiroomi Akashi, Etsuro Ono, Hisashi Arase, Yasushi Kawaguchi
Journal of Virology Vol. 83 No. 9 p. 4520-4527 2009/05 Research paper (scientific journal)
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Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection
Mark T. Orr, Joseph C. Sun, David G.T. Hesslein, Hisashi Arase, Joseph H. Phillips, Toshiyuki Takai, Lewis L. Lanier
Journal of Experimental Medicine Vol. 206 No. 4 p. 807-817 2009/04 Research paper (scientific journal)
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Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface
Akihisa Kato, Jun Arii, Ikuo Shiratori, Hiroomi Akashi, Hisashi Arase, Yasushi Kawaguchi
Journal of Virology Vol. 83 No. 1 p. 250-261 2009/01 Research paper (scientific journal)
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The study of regulatory T cells and NKT cells in Japan: A historical perspective
Hisashi Arase, Ken Ichiro Seino
International Immunology Vol. 21 No. 10 p. 1101-1103 2009 Research paper (scientific journal)
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Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6 - STAT3 signaling pathway
Siyuan Liang, Vladimir Ristich, Hisashi Arase, Jean Dausset, Edgardo D. Carosella, Anatolij Horuzsko
Proceedings of the National Academy of Sciences of the United States of America Vol. 105 No. 24 p. 8357-8362 2008/06/17 Research paper (scientific journal)
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HSV-1 infection through inhibitory receptor, PILRalpha.
Takeshi Satoh, Hisashi Arase
Uirusu. Journal of virology Vol. 58 No. 1 p. 27-36 2008/06
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Bimodal regulation of T cell-mediated immune responses by TIM-4
Masayuki Mizui, Takashi Shikina, Hisashi Arase, Kazuhiro Suzuki, Teruhito Yasui, Paul D. Rennert, Atsushi Kumanogoh, Hitoshi Kikutani
International Immunology Vol. 20 No. 5 p. 695-708 2008/05 Research paper (scientific journal)
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Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors
Shigekazu Tabata, Kimiko Kuroki, Jing Wang, Mizuho Kajikawa, Ikuo Shiratori, Daisuke Kohda, Hisashi Arase, Katsumi Maenaka
Journal of Biological Chemistry Vol. 283 No. 14 p. 8893-8901 2008/04 Research paper (scientific journal)
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An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR)
Jing Wang, Ikuo Shiratori, Takeshi Satoh, Lewis L. Lanier, Hisash Arase
Journal of Immunology Vol. 180 No. 3 p. 1686-1693 2008/02/01 Research paper (scientific journal)
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Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function
Tadahiro Suenaga, Hisashi Arase, Sho Yamasaki, Masayuki Kohno, Tadashi Yokosuka, Arata Takeuchi, Takamichi Hattori, Takashi Saito
European Journal of Immunology Vol. 37 No. 11 p. 3197-3207 2007/11 Research paper (scientific journal)
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T細胞反応におけるTim-4の二相性作用(Biophasic action of Tim-4 on T cell-mediated immune responses)
Mizui Masayuki, Arase Hisashi, Suzuki Kazuhiro, Yasui Teruhito, Kumanogoh Atsushi, Kikutani Hitoshi
日本免疫学会総会・学術集会記録 Vol. 37 p. 220-220 2007/10
Publisher: (NPO)日本免疫学会
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Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors
Erin J. Adams, Z. Sean Juo, Rayna Takaki Venook, Martin J. Boulanger, Hisashi Arase, Lewis L. Lanier, K. Christopher Garcia
<B>Proc. Natl. Acad. Sci. USA</B> Vol. 104 No. 24 p. 10128-10133 2007/06/12 Research paper (scientific journal)
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Cutting edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
William H. Carr, David B. Rosen, Hisashi Arase, Douglas F. Nixon, Jakob Michaelsson, Lewis L. Lanier
Journal of Immunology Vol. 178 No. 2 p. 647-651 2007/01/15 Research paper (scientific journal)
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樹状細胞の機能 トレランスと機能偏向を中心に ナイーブT細胞活性化におけるTim-4の阻害的役割(An inhibitory role of Tim-4 in naive T-cell activation)
Mizui Masayuki, Arase Hisashi, Morihana Tetsuo, Yasui Teruhito, Kumanogoh Atsushi, Kikutani Hitoshi
日本免疫学会総会・学術集会記録 Vol. 36 p. 214-214 2006/11
Publisher: (NPO)日本免疫学会
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Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer
Mitsunori Shiroishi, Kimiko Kuroki, Toyoyuki Ose, Linda Rasubala, Ikuo Shiratori, Hisashi Arase, Kouhei Tsumoto, Izumi Kumagai, Daisuke Kohda, Katsumi Maenaka
Journal of Biological Chemistry Vol. 281 No. 15 p. 10439-10447 2006/04 Research paper (scientific journal)
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Mechanisms in evasion of host immune response by HCMV
Takeshi Satoh, Hisashi Arase
Nippon rinsho. Japanese journal of clinical medicine Vol. 64 Suppl 3 p. 421-426 2006/03
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Regulation of innate immunity by paired receptors
Hisashi Arase
International Congress Series Vol. 1285 p. 60-67 2005/11 Research paper (scientific journal)
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Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200
Ikuo Shiratori, Masao Yamaguchi, Maho Suzukawa, Kazuhiko Yamamoto, Lewis L. Lanier, Takashi Saito, Hisashi Arase
Journal of Immunology Vol. 175 No. 7 p. 4441-4449 2005/10/01 Research paper (scientific journal)
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Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells
Noriko Arase, Arata Takeuchi, Midori Unno, Satoshi Hirano, Tadashi Yokosuka, Hisashi Arase, Takashi Saito
International Immunology Vol. 17 No. 9 p. 1227-1237 2005/09 Research paper (scientific journal)
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NK cells and NKT cells
Takeshi Satoh, Hisashi Arase
Nippon rinsho. Japanese journal of clinical medicine Vol. 63 Suppl 4 p. 159-165 2005/04
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Recognition of virus infected cells by NK cells
Hisashi Arase, Ikuo Shiratori
Uirusu. Journal of virology Vol. 54 No. 2 p. 153-160 2004/12
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Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR)
Satoru Ishikawa, Noriko Arase, Tadashi Suenaga, Yoshitomo Saita, Masaki Noda, Takayuki Kuriyama, Hisashi Arase, Takashi Saito
International Immunology Vol. 16 No. 7 p. 1019-1025 2004/07 Research paper (scientific journal)
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NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling
Makoto Ohtsuka, Hisashi Arase, Arata Takeuchi, Sho Yamasaki, Ritsuko Shiina, Tadahiro Suenaga, Daiju Sakurai, Tadashi Yokosuka, Noriko Arase, Makio Iwashima, Toshio Kitamura, Hideshige Moriya, Takashi Saito
Proceedings of the National Academy of Sciences of the United States of America Vol. 101 No. 21 p. 8126-8131 2004/05/21 Research paper (scientific journal)
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Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
James R. Carlyle, Amanda M. Jamieson, Stephan Gasser, Christopher S. Clingan, Hisashi Arase, David H. Raulet
Proceedings of the National Academy of Sciences of the United States of America Vol. 101 No. 10 p. 3527-3532 2004/03/09 Research paper (scientific journal)
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Specific recognition of virus-infected cells by paired NK receptors
Hisashi Arase, Lewis L. Lanier
Reviews in Medical Virology Vol. 14 No. 2 p. 83-93 2004/03 Research paper (scientific journal)
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Activation of Natural Killer Cells and Dendritic Cells upon Recognition of a Novel CD99-like Ligand by Paired Immunoglobulin-like Type 2 Receptor
Ikuo Shiratori, Kouetsu Ogasawara, Takashi Saito, Lewis L. Lanier, Hisashi Arase
Journal of Experimental Medicine Vol. 199 No. 4 p. 525-533 2004/02/16 Research paper (scientific journal)
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FcεIγ-ITAM Is Differentially Required for Mast Cell Function in Vivo
Daiju Sakurai, Sho Yamasaki, Kanako Arase, Seung Yong Park, Hisashi Arase, Akiyoshi Konno, Takashi Saito
Journal of Immunology Vol. 172 No. 4 p. 2374-2381 2004/02/15 Research paper (scientific journal)
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NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
Melissa Lodoen, Kouetsu Ogasawara, Jessica A. Hamerman, Hisashi Arase, Jeffrey P. Houchins, Edward S. Mocarski, Lewis L. Lanier
Journal of Experimental Medicine Vol. 197 No. 10 p. 1245-1253 2003/05/19 Research paper (scientific journal)
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IgE-mediated activation of NK cells through FcγRIII
Noriko Arase, Hisashi Arase, Satoshi Hirano, Tadashi Yokosuka, Daiju Sakurai, Takashi Saito
Journal of Immunology Vol. 170 No. 6 p. 3054-3058 2003/03/15 Research paper (scientific journal)
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Evolution of NK cell receptors and virus
Hisashi Arase
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 47 No. 16 Suppl p. 2127-2132 2002/12
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Virus-driven evolution of natural killer cell receptors
Hisashi Arase, Lewis L. Lanier
Microbes and Infection Vol. 4 No. 15 p. 1505-1512 2002/12 Research paper (scientific journal)
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Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
Hisashi Arase, Edward S. Mocarski, Ann E. Campbell, Ann B. Hill, Lewis L. Lanier
Science Vol. 296 No. 5571 p. 1323-1326 2002/05/17 Research paper (scientific journal)
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Predominant role of T cell receptor (TCR)-α chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system
Tadashi Yokosuka, Kan Takase, Misao Suzuki, Yohko Nakagawa, Shinsuke Taki, Hidemi Takahashi, Takehiko Fujisawa, Hisashi Arase, Takashi Saito
Journal of Experimental Medicine Vol. 195 No. 8 p. 991-1001 2002/04 Research paper (scientific journal)
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Cutting edge: Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly
K. Itoh, M. Sakakibara, S. Yamasaki, A. Takeuchi, H. Arase, M. Miyazaki, N. Nakajima, M. Okada, T. Saito
Journal of Immunology Vol. 168 No. 2 p. 541-544 2002/01/15 Research paper (scientific journal)
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130 IgEによるマスト細胞の生存延長シグナルはFcεRIγ鎖ITAMを介する
櫻井 大樹, 荒瀬 佳奈子, 朴 承龍, 山崎 晶, 荒瀬 尚, 今野 昭義, 斎藤 隆
アレルギー Vol. 51 No. 2 p. 275-275 2002
Publisher: 一般社団法人 日本アレルギー学会
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E2A and HEB activate the pre-TCRα promoter during immature T cell development
A. Takeuchi, S. Yamasaki, K. Takase, F. Nakatsu, H. Arase, M. Onodera, T. Saito
Journal of Immunology Vol. 167 No. 4 p. 2157-2163 2001/08/15 Research paper (scientific journal)
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Cutting edge: The mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (α<inf>2</inf> integrin, very late antigen-2)
H. Arase, T. Saito, J. H. Phillips, L. L. Lanier
Journal of Immunology Vol. 167 No. 3 p. 1141-1144 2001/08/01 Research paper (scientific journal)
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Cytokine-independent Jak3 Activation upon T Cell Receptor (TCR) Stimulation through Direct Association of Jak3 and the TCR Complex
Kazuhiro Tomita, Kaoru Saijo, Sho Yamasaki, Tomohiko Iida, Fubito Nakatsu, Hisashi Arase, Hiroshi Ohno, Takuji Shirasawa, Takayuki Kuriyama, John J. O'Shea, Takashi Saito
Journal of Biological Chemistry Vol. 276 No. 27 p. 25378-25385 2001/07/06 Research paper (scientific journal)
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Negative regulation of expression and function of FcγRIII by CD3ζ in murine NK cells
H. Arase, T. Suenaga, N. Arase, Y. Kimura, K. Ito, R. Shiina, H. Ohno, T. Saito
Journal of Immunology Vol. 166 No. 1 p. 21-25 2001/01/01 Research paper (scientific journal)
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The quantity of TCR signal determines positive selection and lineage commitment of T cells
N. Watanabe, H. Arase, M. Onodera, P. S. Ohashi, T. Saito
Journal of Immunology Vol. 165 No. 11 p. 6252-6261 2000/12/01 Research paper (scientific journal)
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Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
T. Iida, H. Ohno, C. Nakaseko, M. Sakuma, M. Takeda-Ezaki, H. Arase, E. Kominami, T. Fujisawa, T. Saito
Journal of Immunology Vol. 165 No. 9 p. 5062-5068 2000/11/01 Research paper (scientific journal)
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A di-leucine signal in the ubiquitin moiety: Possible involvement in ubiqutination-mediated endocytosis
Fubito Nakatsu, Machie Sakuma, Yo Matsuo, Hisashi Arase, Sho Yamasaki, Nobuhiro Nakamura, Takashi Saito, Hiroshi Ohno
Journal of Biological Chemistry Vol. 275 No. 34 p. 26213-26219 2000/08/25 Research paper (scientific journal)
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Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses
Yuki Hamano, Hisashi Arase, Hiromitsu Saisho, Takashi Saito
Journal of Immunology Vol. 164 No. 12 p. 6113-6119 2000/06/15 Research paper (scientific journal)
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Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene
Kanako Arase, Kaoru Saijo, Hiroyuki Watanabe, Akiyoshi Konno, Hisashi Arase, Takashi Saito
Proceedings of the National Academy of Sciences of the United States of America Vol. 96 No. 16 p. 9264-9268 1999/08/03 Research paper (scientific journal)
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Resistance of Fc receptor-deficient mice to fatal glomerulonephritis
Seung Yong Park, Shiro Ueda, Hiroshi Ohno, Yuki Hamano, Misaki Tanaka, Tooru Shiratori, Tetsuo Yamazaki, Hisashi Arase, Noriko Arase, Akira Karasawa, Soichiro Sato, Birgit Ledermann, Yoichiro Kondo, Ko Okumura, Chisel Ra, Takashi Saito
Journal of Clinical Investigation Vol. 102 No. 6 p. 1229-1238 1998/09/15 Research paper (scientific journal)
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Association with FcRγ is essential for activation signal through NKR- P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells
Noriko Arase, Hisashi Arase, Seung Yong Park, Hiroshi Ohno, Chisei Ra, Takashi Saito
Journal of Experimental Medicine Vol. 186 No. 12 p. 1957-1963 1997/12/15 Research paper (scientific journal)
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Th1 and Th2 subsets equally undergo Fas-dependent and -independent activation-induced cell death
Norihiko Watanabe, Hisashi Arase, Kazuhiro Kurasawa, Itsuo Iwamoto, Nobuhiko Kayagaki, Hideo Yagita, Ko Okumura, Shoichiro Miyatake, Takashi Saito
European Journal of Immunology Vol. 27 No. 8 p. 1858-1864 1997/08 Research paper (scientific journal)
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Influence of graft versus host reaction on the T cell repertoire differentiating from bone marrow precursors following allogeneic bone marrow transplantation
Kazunori Onoé, Noriko Arase, Hisashi Arase, Toshiaki Takayanagi, Hiroki Nishihori, Kazuya Iwabuchi, Kazumasa Ogasawara, Robert A. Good
Transplant Immunology Vol. 5 No. 2 p. 75-82 1997/06 Research paper (scientific journal)
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A Shift from Negative to Positive Selection of Autoreactive T Cells by the Reduced Level of TCR Signal in TCR-Transgenic CD3ζ-Deficient Mice
Tetsuo Yamazaki, Hisashi Arase, Satoru Ono, Hiroshi Ohno, Hiroyuki Watanabe, Takashi Saito
Journal of Immunology Vol. 158 No. 4 p. 1634-1640 1997/02/15 Research paper (scientific journal)
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Crucial role of Jak3 in negative selection of self-reactive T cells
Kaoru Saijo, Seung Yong Park, Yasuo Ishida, Hisashi Arase, Takashi Saito
Journal of Experimental Medicine Vol. 185 No. 2 p. 351-356 1997/01/20 Research paper (scientific journal)
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Interferon γ production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking
Hisashi Arase, Noriko Arase, Takashi Saito
Journal of Experimental Medicine Vol. 183 No. 5 p. 2391-2396 1996/05/01 Research paper (scientific journal)
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Mitogenic effect of HIV-infected human T cell lines on mouse B cells mediated by surface immunoglobulin
N. Arase, H. Arase, K. Ohki, Y. Nishino, K. Ikuta, K. Onoé
Clinical and Experimental Immunology Vol. 103 No. 1 p. 24-29 1996 Research paper (scientific journal)
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Preferential requirement of CD3ζ-mediated signals for development of immature rather than mature thymocytes
Tomohiko Aoe, Yasuhiro Okamoto, Hisashi Arase, Koichi Ikuta, Jun Ichi Miyazaki, Satoru Ono, Mizuto Otuji, Hiroshi Ohno, Sho Ichiro Miyatake, Takashi Saito
International Immunology Vol. 8 No. 7 p. 1055-1066 1996 Research paper (scientific journal)
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Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
Seung Yong Park, Kaoru Saijo, Takamune Takahashi, Masataka Osawa, Hisashi Areas, Nakami Hirayama, Keiko Miyake, Hiromitsu Nakauchi, Takuji Shirasawa, Takashi Saito
Immunity Vol. 3 No. 6 p. 771-782 1995/12 Research paper (scientific journal)
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Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-α/β+ T cells and expansion of NK1.1+ TCR-γ/δ+ T cell development in CD3ζ-deficient mice
Hisashi Arase, Satoru Ono, Noriko Arase, Seung Yong Park, Keisuke Wakizaka, Hiroyuki Watanabe, Hiroshi Ohno, Takashi Saito
Journal of Experimental Medicine Vol. 182 No. 3 p. 891-895 1995/09/01 Research paper (scientific journal)
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Differential contribution of the FcRγ chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcRγ‐deficient mice
Seung Yong Park, Hisashi Arase, Keisuke Wakizaka, Nakami Hirayama, Shigehiro Masaki, So‐Ichiro ‐I Sato, Jeffrey V. Ravetch, Takashi Saito
European Journal of Immunology Vol. 25 No. 7 p. 2107-2110 1995/07 Research paper (scientific journal)
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Fas-mediated cytotoxicity by freshly isolated natural killer cells
Hisashi Arase, Noriko Arase, Takashi Saito
Journal of Experimental Medicine Vol. 181 No. 3 p. 1235-1238 1995/03/01 Research paper (scientific journal)
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Production of Minor Lymphocyte Stimulatory-1a Antigens from T Cell Subsets
Noriko Arase, Hisashi Arase, Toshiaki Takayanagi, Machiko Mishima, Kazuya Iwabuchi, Kazumasa Ogasawara, Kazunori Onoé
Immunobiology Vol. 193 No. 5 p. 378-390 1995 Research paper (scientific journal)
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Cytotoxicity of fresh nki.1+ t cell receptor α/β+ thymocytes against a cd4+8+ thymocyte population associated with intact fas antigen expression on the target
Hisashi Arase, Noriko Arase, Yuko Kobayashi, Yoshiko Nishimura, Shin Yonehara, Kazunori Onoé
Journal of Experimental Medicine Vol. 180 No. 2 p. 423-432 1994/08/01 Research paper (scientific journal)
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Contribution of host radioresistant T cells to the clonal elimination of minor lymphocyte stimulatory-1a reactive T cells in mouse bone marrow chimeras
Noriko Arase, Hisashi Arase, Robert A. Good, Kazunori OnoÉ
Cellular Immunology Vol. 156 No. 1 p. 13-23 1994/06 Research paper (scientific journal)
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Comparative Analyses of Thymocyte and Thymic Low-Density Adherent Cell Functions
Peter P. Wambua, Kazuya Iwabuch, Chikako Iwabuchi, Kazumasa Ogasawara, Yasushi Itoh, Hisashi Arase, Masaharu Kajiwara, Toshihiko Gotohda, Kiichi Kajino, Robert A. Good, Kazunori Onoe
Microbiology and Immunology Vol. 38 No. 11 p. 879-890 1994 Research paper (scientific journal)
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Functional studies on MEL-14+ and MEL-14− T cells in peripheral lymphoid tissues
Jun Ohgama, Masahito Katoh, Mari Hirano, Hisashi Arase, Noriko Arase-Fukushi, Machiko Mishima, Kazuya Iwabuchi, Kazumasa Ogasawara, Kazunori Onoé
Immunobiology Vol. 190 No. 3 p. 225-242 1994 Research paper (scientific journal)
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Reconstitution of lymphoid tissues under the influence of a subclinical level of graft versus host reaction induced by bone marrow t cells or splenic t cell subsets
Mari Hirano, Hisashi Arase, Noriko Arase-Fukushi, Kazumasa Ogasawara, Kazuya Iwabuchi, Tamotsu Miyazaki, Robert A. Good, Kazunori Onoé
Cellular Immunology Vol. 151 No. 1 p. 118-132 1993/10/01 Research paper (scientific journal)
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Influence of a Small Number of Mature T Cells in Donor Bone Marrow Inocula on Reconstitution of Lymphoid Tissues and Negative Selection of a T Cell Repertoire in the Recipient
Noriko Arase-Fukushi, Hisashi Arase, Bingyan Wang, Mari Hirano, Kazumasa Ogasawara, Kazunori Onoe, Mari Hirano, Robert A. Good
Microbiology and Immunology Vol. 37 No. 11 p. 883-894 1993 Research paper (scientific journal)
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Production of minor lymphocyte stimulatory-1a antigen from activated CD4+ or CD8+ T cells
N. Arase-Fukushi, H. Arase, K. Ogasawara, R. A. Good, K. Onoe
Journal of Immunology Vol. 151 No. 9 p. 4445-4454 1993 Research paper (scientific journal)
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NK1.1+ CD4+ CD8‐ thymocytes with specific lymphokine secretion
Hisashi Arase, Noriko Arase, Ken‐Ichi ‐I Nakagawa, Robert A. Good, Kazunori Onoé
European Journal of Immunology Vol. 23 No. 1 p. 307-310 1993/01 Research paper (scientific journal)
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Lymphokine-activated killer cell activity of CD4-CD8- TCRαβ+ thymocytes
H. Arase, N. Arase-Fukushi, R. A. Good, K. Onoe
Journal of Immunology Vol. 151 No. 2 p. 546-555 1993 Research paper (scientific journal)
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Clonal elimination of self reactive V<inf>β</inf>6+ T cells induced by H-2 products expressed on thymic radio-resistant components
Hisashi Arase, Noriko Arase, Kazumasa Ogasawara, Robert A. Good, Kazunori Onoé
International Immunology Vol. 4 No. 1 p. 75-82 1992/01 Research paper (scientific journal)
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An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V(β) family
H. Arase, N. Arase, K. Ogasawara, R. A. Good, K. Onoe
Proceedings of the National Academy of Sciences of the United States of America Vol. 89 No. 14 p. 6506-6510 1992 Research paper (scientific journal)
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Deficiency in early development of the thymus-dependent cells in irradiation chimeras attributable to recipient's environment
C. Iwabuchi, K. Iwabuchi, S. Kobayashi, K. Ogasawara, I. Negishi, B. Wang, P. P. Wambua, H. Arase, N. Fukushi, Y. Itoh, T. Gotohda, R. A. Good, K. Onoe
Journal of Immunology Vol. 146 No. 1 p. 26-34 1991 Research paper (scientific journal)
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Thymus: A direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance
Noriko Fukushi, Hisashi Arase, Bingyan Wang, Kazumasa Ogasawara, Toshihiko Gotohda, Robert A. Good, Kazunori Onoé
Proceedings of the National Academy of Sciences of the United States of America Vol. 87 No. 16 p. 6301-6305 1990/08 Research paper (scientific journal)
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Cell components required for deletion of an autoreactive T cell repertoire
Noriko Fukushi, Bingyan Wang, Hisashi Arase, Kazumasa Ogasawara, Robert A. Good, Kazunori Onoé
European Journal of Immunology Vol. 20 No. 5 p. 1153-1160 1990/05 Research paper (scientific journal)
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Sequential Analysis of the Thymocyte Differentiation in Fully Allogeneic Bone Marrow Chimera in Mice.I. Relationship between Functions and Surface Characteristics of Thymocytes
Kazumasa Ogasawara, Noriko Fukushi, Hisashi Arase, Chikako Iwabuchi, Shigetsugu Hatakeyama, Kazuya Iwabuchi, Robert A. Good, Kazunori Onoá
Immunobiology Vol. 180 No. 2-3 p. 149-166 1990 Research paper (scientific journal)
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Sequential Analysis of the Thymocyte Differentiation in Fully Allogeneic Bone Marrow Chimera in Mice. II. Further Characterization of the CD4+ or CD8+ Single Positive Thymocytes
Hisashi Arase, Noriko Fukushi, Shigetsugu Hatakeyama, Kazumasa Ogasawara, Kazuya Iwabuchi, Chikako Iwabuchi, Izumi Negishi, Robert A. Good, Kazunori Onoé
Immunobiology Vol. 180 No. 2-3 p. 167-183 1990 Research paper (scientific journal)
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Donor and Recipient Specific Tolerance in Cells from Semi-Allogeneic, H-2 Subregion Compatible or Fully Allogeneic Bone Marrow Chimeras Attributable to Clonal
Kazunori Onoe, Kazuya Iwabuchi, Chikako Iwabuchi, Hisashi Arase, Shigetsugu Hatakeyama, Peter P. Wambua, Noriko Fukushi, Izumi Negishi, Robert A. Good, Kazumasa Ogasawara
Immunobiology Vol. 179 No. 2-3 p. 172-189 1989 Research paper (scientific journal)
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Positive selection of a T-cell subpopulation in the thymus in which it develops
K. Iwabuchi, I. Negishi, H. Arase, C. Iwabuchi, K. Ogasawara, R. A. Good, K. Onoe
Proceedings of the National Academy of Sciences of the United States of America Vol. 86 No. 13 p. 5089-5093 1989 Research paper (scientific journal)
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