Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors.

Yuho Murata, Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda

eLife　Vol. 12　2024/01/22　Research paper (scientific journal)

Anti-Malarial Activity of Allyl Isothiocyanate and N-acetyl-S-(N-allylthiocarbamoyl)-l-Cysteine.

Takashi Hashimoto, Shoji Yoshioka, Shiroh Iwanaga, Kazuki Kanazawa

Molecular nutrition & food research　Vol. 67　No. 21　2023/11　Research paper (scientific journal)

A possible circulation of a dominant Dibothriocephalus nihonkaiensis haplotype in Japan revealed by molecular analysis of clinical tapeworm samples.

Danielle Ladzekpo, Kofi Dadzie Kwofie, Hayato Kawada, Fusako Mikami, Naotoshi Tsuji, Shiroh Iwanaga, Samuel Kweku Dadzie, Takeshi Hatta, Tomoko Ishino

Parasitology international　Vol. 96　p. 102771-102771　2023/10/01　Research paper (scientific journal)

RNA activation in ticks.

Kofi Dadzie Kwofie, Emmanuel Pacia Hernandez, Anisuzzaman, Hayato Kawada, Yuki Koike, Sana Sasaki, Takahiro Inoue, Kei Jimbo, Fusako Mikami, Danielle Ladzekpo, Rika Umemiya-Shirafuji, Kayoko Yamaji, Tetsuya Tanaka, Makoto Matsubayashi, Md Abdul Alim, Samuel Kweku Dadzie, Shiroh Iwanaga, Naotoshi Tsuji, Takeshi Hatta

Scientific reports　Vol. 13　No. 1　p. 9341-9341　2023/06/08　Research paper (scientific journal)

Differentiation of Plasmodium male gametocytes is initiated by the recruitment of a chromatin remodeler to a male-specific cis-element.

Izumi Kaneko, Tsubasa Nishi, Shiroh Iwanaga, Masao Yuda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 20　2023/05/16　Research paper (scientific journal)

Evaluating the mosquito host range of Getah virus and the vector competence of selected medically important mosquitoes in Getah virus transmission.

Faustus Akankperiwen Azerigyik, Astri Nur Faizah, Daisuke Kobayashi, Michael Amoa-Bosompem, Ryo Matsumura, Izumi Kai, Toshinori Sasaki, Yukiko Higa, Haruhiko Isawa, Shiroh Iwanaga, Tomoko Ishino

Parasites & vectors　Vol. 16　No. 1　p. 99-99　2023/03/15　Research paper (scientific journal)

Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

Emi Hashizaki, Miwa Sasai, Daisuke Okuzaki, Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga, Masahiro Yamamoto

mBio　Vol. 14　No. 1　2023/02/28　Research paper (scientific journal)

PbAP2-FG2 and PbAP2R-2 function together as a transcriptional repressor complex essential for Plasmodium female development.

Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda

PLoS pathogens　Vol. 19　No. 2　2023/02/13　Research paper (scientific journal)

Targetome Analysis of Malaria Sporozoite Transcription Factor AP2-Sp Reveals Its Role as a Master Regulator.

Masao Yuda, Izumi Kaneko, Yuho Murata, Shiroh Iwanaga, Tsubasa Nishi

mBio　Vol. 14　No. 1　2023/01/09　Research paper (scientific journal)

Plasmodium 6-cysteine proteins determine the commitment of sporozoites to liver-infection.

Masao Yuda, Izumi Kaneko, Yuho Murata, Shiroh Iwanaga, Kazuhiro Okubo, Tsubasa Nishi

Parasitology international　Vol. 93　p. 102700-102700　2022/11/18　Research paper (scientific journal)

Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum.

Shiroh Iwanaga, Rie Kubota, Tsubasa Nishi, Sumalee Kamchonwongpaisan, Somdet Srichairatanakool, Naoaki Shinzawa, Din Syafruddin, Masao Yuda, Chairat Uthaipibull

Nature communications　Vol. 13　No. 1　p. 6163-6163　2022/10/18　Research paper (scientific journal)

Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development.

Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda

PLoS pathogens　Vol. 18　No. 8　2022/08/10　Research paper (scientific journal)

Layer-by-Layer Delivery of Multiple Antigens Using Trimethyl Chitosan Nanoparticles as a Malaria Vaccine Candidate.

Yang Xu, Ziyou Zhou, Brad Brooks, Tammy Ferguson, Judy Obliosca, Jing Huang, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Yukiko Tsuji, Huitang Zhang, Christina C Luo, Xunqing Jiang, Xiang-Peng Kong, Moriya Tsuji, Christopher K Tison

Frontiers in immunology　Vol. 13　p. 900080-900080　2022/08/01　Research paper (scientific journal)

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium.

Ana Rafaela Teixeira, Begoña Pérez-Cabezas, David M Costa, Mónica Sá, Sylvain Golba, Hélèna Sefiane-Djemaoune, Joana Ribeiro, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji, Silvia Beatriz Boscardin, Rogerio Amino, Anabela Cordeiro-da-Silva, Joana Tavares

Frontiers in immunology　Vol. 13　p. 868305-868305　2022/05/01　Research paper (scientific journal)

Evaluation of the Effect of Gene Duplication by Genome Editing on Drug Resistance in Plasmodium falciparum.

Rie Kubota, Tomoko Ishino, Shiroh Iwanaga, Naoaki Shinzawa

Frontiers in cellular and infection microbiology　Vol. 12　p. 915656-915656　2022/05/01　Research paper (scientific journal)

Calpain inhibitor suppresses both extracellular vesicle-mediated secretion of miRNAs and egg production from paired adults of Schistosoma japonicum.

Takashi Kumagai, Rieko Shimogawara, Koichiro Ichimura, Shiroh Iwanaga

Parasitology international　Vol. 87　p. 102540-102540　2022/04/01　Research paper (scientific journal)

Chromosome splitting of Plasmodium berghei using the CRISPR/Cas9 system.

Daniel Addo-Gyan, Haruka Matsushita, Enya Sora, Tsubasa Nishi, Masao Yuda, Naoaki Shinzawa, Shiroh Iwanaga

PloS one　Vol. 17　No. 2　2022/02/24　Research paper (scientific journal)

Insights and genetic features of extended-spectrum beta-lactamase producing Escherichia coli isolates from two hospitals in Ghana

Samiratu Mahazu, Wakana Sato, Alafate Ayibieke, Isaac Prah, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

Scientific Reports　Vol. 12　No. 1　2022/02　Research paper (scientific journal)

Screening for tick-borne and tick-associated viruses in ticks collected in Ghana

Michael Amoa-Bosompem, Daisuke Kobayashi, Astri Nur Faizah, Shohei Kimura, Ama Antwi, Esinam Agbosu, Deborah Pratt, Mitsuko Ohashi, Joseph H. Kofi Bonney, Samuel Dadzie, Hiroko Ejiri, Nobuo Ohta, Kyoko Sawabe, Shiroh Iwanaga, Haruhiko Isawa

Archives of Virology　Vol. 167　No. 1　p. 123-130　2022/01　Research paper (scientific journal)

Possible Dissemination of Escherichia coli Sequence Type 410 Closely Related to B4/H24RxC in Ghana

Samiratu Mahazu, Isaac Prah, Alafate Ayibieke, Wakana Sato, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

Frontiers in Microbiology　Vol. 12　p. 770130-770130　2021/12/01　Research paper (scientific journal)

Mechanisms of triggering malaria gametocytogenesis by AP2-G

Masao Yuda, Izumi Kaneko, Yuho Murata, Shiroh Iwanaga, Tsubasa Nishi

Parasitology International　Vol. 84　2021/10/01　Research paper (scientific journal)

Highly efficient CRISPR/Cas9 system in Plasmodium falciparum using Cas9-expressing parasites and a linear donor template.

Tsubasa Nishi, Naoaki Shinzawa, Masao Yuda, Shiroh Iwanaga

Scientific reports　Vol. 11　No. 1　p. 18501-18501　2021/09/16　Research paper (scientific journal)

Species composition and risk of transmission of some Aedes-borne arboviruses in some sites in Northern Ghana

Joannitta Joannides, Mawuli Dzodzomenyo, Faustus Azerigyik, Eudocia Esinam Agbosu, Deborah Pratt, Joseph Harold Nyarko Osei, Rebecca Pwalia, Godwin Kwame Amlalo, Maxwell Appawu, Hayashi Takashi, Shiroh Iwanaga, Andrea Buchwald, Rosemary Rochford, Daniel Boakye, Kwadwo Koram, Kofi Bonney, Samuel Dadzie

PLoS ONE　Vol. 16　No. 6-Jun　2021/06/01　Research paper (scientific journal)

Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana

Isaac Prah, Alafate Ayibieke, Samiratu Mahazu, Chihiro Tani Sassa, Takaya Hayashi, Shoji Yamaoka, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

Emerging Microbes and Infections　Vol. 10　No. 1　p. 865-873　2021/05/04　Research paper (scientific journal)

Determining vector competence of Aedes aegypti from Ghana in transmitting dengue virus serotypes 1 and 2

Michael Amoa-Bosompem, Daisuke Kobayashi, Kentaro Itokawa, Katsunori Murota, Astri Nur Faizah, Faustus Akankperiwen Azerigyik, Takaya Hayashi, Mitsuko Ohashi, Joseph H.Kofi Bonney, Samuel Dadzie, Cuong Chi Tran, Phong Vu Tran, Ryosuke Fujita, Yoshihide Maekawa, Shinji Kasai, Shoji Yamaoka, Nobuo Ohta, Kyoko Sawabe, Shiroh Iwanaga, Haruhiko Isawa

Parasites and Vectors　Vol. 14　No. 1　2021/04/01　Research paper (scientific journal)

Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2

Akihito Sakoguchi, Fumiji Saito, Kouyuki Hirayasu, Kyoko Shida, Sumiko Matsuoka, Sawako Itagaki, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Shiroh Iwanaga, Toshihiro Horii, Hisashi Arase

Biochemical and Biophysical Research Communications　Vol. 548　p. 167-173　2021/04/01　Research paper (scientific journal)

Virulence profiles of diarrheagenic escherichia coli isolated from the western region of Ghana

Isaac Prah, Alafate Ayibieke, Thi Thu Huong Nguyen, Atsushi Iguchi, Samiratu Mahazu, Wakana Sato, Takaya Hayashi, Shoji Yamaoka, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

Japanese Journal of Infectious Diseases　Vol. 74　No. 2　p. 115-121　2021/03/24　Research paper (scientific journal)

蚊細胞株内でのゲタウイルスの増殖動態の評価(Evaluation of the growth kinetics of Getah virus in a scope of mosquito cell lines)

Azerigyik Faustus, Kobayashi Daisuke, Amoa-Bosompem Michael, Faizah Astri Nur, Iwanaga Shiroh, Isawa Haruhiko

衛生動物　Vol. 72　No. Suppl.　p. 47-47　2021/03

ガーナで採集したダニにおけるダニ媒介性及びダニ関連ウイルスのスクリーニング(Screening for tick-borne and tick-associated viruses in ticks collected in Ghana)

Amoa-Bosompem Michael, Kobayashi Daisuke, Faizah Astri Nur, Ejiri Hiroko, Sawabe Kyoko, Iwanaga Shiroh, Isawa Haruhiko

衛生動物　Vol. 72　No. Suppl.　p. 64-64　2021/03

Evaluation of the growth kinetics of Getah virus in a scope of mosquito cell lines(和訳中)

Azerigyik Faustus, Kobayashi Daisuke, Amoa-Bosompem Michael, Faizah Astri Nur, Iwanaga Shiroh, Isawa Haruhiko

衛生動物　Vol. 72　No. Suppl.　p. 47-47　2021/03

Screening for tick-borne and tick-associated viruses in ticks collected in Ghana(和訳中)

Amoa-Bosompem Michael, Kobayashi Daisuke, Faizah Astri Nur, Ejiri Hiroko, Sawabe Kyoko, Iwanaga Shiroh, Isawa Haruhiko

衛生動物　Vol. 72　No. Suppl.　p. 64-64　2021/03

ガーナ産ネッタイシマカ由来新規培養細胞系の樹立と性状解析

伊澤 晴彦, マイケル・アモア-ボソムペム, 小林 大介, 鍬田 龍星, 糸川 健太郎, アシトリ・ヌー・ファイザー, 岩永 史朗

衛生動物　Vol. 72　No. Suppl.　p. 48-48　2021/03

Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase 2 From the Endoplasmic Reticulum in Plasmodium falciparum

Izumi Taku, Tomohiro Hirai, Takashi Makiuchi, Naoaki Shinzawa, Shiroh Iwanaga, Takeshi Annoura, Kisaburo Nagamune, Tomoyoshi Nozaki, Yumiko Saito-Nakano

Frontiers in Cellular and Infection Microbiology　Vol. 10　p. 610200-610200　2021/02/02　Research paper (scientific journal)

Improvement of CRISPR/Cas9 system by transfecting Cas9-expressing Plasmodium berghei with linear donor template

Naoaki Shinzawa, Tsubasa Nishi, Fumiya Hiyoshi, Daisuke Motooka, Masao Yuda, Shiroh Iwanaga

Communications Biology　Vol. 3　No. 1　p. 426-426　2020/12/01　Research paper (scientific journal)

Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-Producing Acinetobacter Isolates From Ghana

Alafate Ayibieke, Ayumi Kobayashi, Masato Suzuki, Wakana Sato, Samiratu Mahazu, Isaac Prah, Miyuki Mizoguchi, Kyoji Moriya, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

Frontiers in Microbiology　Vol. 11　p. 587398-587398　2020/11/13　Research paper (scientific journal)

Establishment and characterization of a cell line from Ghanaian Aedes aegypti (Diptera: Culicidae) focusing on Aedes-borne flavivirus susceptibility

Michael Amoa-Bosompem, Daisuke Kobayashi, Kentaro Itokawa, Astri Nur Faizah, Ryusei Kuwata, Samuel Dadzie, Takaya Hayashi, Shoji Yamaoka, Kyoko Sawabe, Shiroh Iwanaga, Haruhiko Isawa

In Vitro Cellular and Developmental Biology - Animal　Vol. 56　No. 9　p. 792-798　2020/10　Research paper (scientific journal)

ガーナで採集したネッタイシマカ(Aedes aegypti)のウイルス集団解析とアルボウイルス伝播におけるネッタイシマカの役割可能性(Virome analyses of Aedes aegypti mosquitoes collected in Ghana and their possible impact on arbovirus transmission)

Amoa-Bosompem Michael, Kobayashi Daisuke, Murota Katsunori, Faizah Astri Nur, Itokawa Kentaro, Ohashi Mitsuko, Sasaki Toshinori, Isawa Haruhiko, Sawabe Kyoko, Iwanaga Shiroh

衛生動物　Vol. 71　No. Suppl.　p. 62-62　2020/03

Entomological assessment of the status and risk of mosquito-borne arboviral transmission in Ghana

Michael Amoa-Bosompem, Daisuke Kobayashi, Katsunori Murota, Astri Nur Faizah, Kentaro Itokawa, Ryosuke Fujita, Joseph Harold Nyarko Osei, Esinam Agbosu, Deborah Pratt, Shohei Kimura, Kofi Dadzie Kwofie, Mitsuko Ohashi, Joseph H.Kofi Bonney, Samuel Dadzie, Toshinori Sasaki, Nobuo Ohta, Haruhiko Isawa, Kyoko Sawabe, Shiroh Iwanaga

Viruses　Vol. 12　No. 2　2020　Research paper (scientific journal)

Female-specific gene regulation in malaria parasites by an AP2-family transcription factor

Masao Yuda, Izumi Kaneko, Shiroh Iwanaga, Yuho Murata, Tomomi Kato

Molecular Microbiology　Vol. 113　No. 1　p. 40-51　2020/01/01　Research paper (scientific journal)

CXCR4 regulates Plasmodium development in mouse and human hepatocytes

Hironori Bando, Ariel Pradipta, Shiroh Iwanaga, Toru Okamoto, Daisuke Okuzaki, Shun Tanaka, Joel Vega-Rodríguez, Youngae Lee, Ji Su Ma, Naoya Sakaguchi, Akira Soga, Shinya Fukumoto, Miwa Sasai, Yoshiharu Matsuura, Masao Yuda, Marcelo Jacobs-Lorena, Masahiro Yamamoto

Journal of Experimental Medicine　Vol. 216　No. 8　p. 1733-1748　2019/08/01　Research paper (scientific journal)

Antimalarial activity of vitamin D3 (VD3)does not result from VD3-induced antimicrobial agents including nitric oxide or cathelicidin

Kiichi Yamamoto, Kentaro Takahashi, Manabu Ato, Shiroh Iwanaga, Nobuo Ohta

Experimental Parasitology　Vol. 201　p. 67-77　2019/06　Research paper (scientific journal)

Establishment of a quantitative and qualitative analysis and isolation method for tetracyclic iridoids from Morinda lucida Bentham leaves

Tomoe Ohta, Tanatorn Tilkanont, Frederick Ayertey, Mina Nakagawa, Nguyen Huu Tung, Peter Bolah, Heron Blagogee, Alfred Ampomah Appiah, Augustine Ocloo, Mitsuko Ohashi, Kensuke Tanoue, Yasuchika Yamaguchi, Nobuo Ohta, Shoji Yamaoka, Shiro Iwanaga, Takuhiro Uto, Yukihiro Shoyama

Journal of Pharmaceutical and Biomedical Analysis　Vol. 164　p. 475-480　2019/02/05　Research paper (scientific journal)

Molecular characterisation of the NDM-1encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana

Alafate Ayibieke, Wakana Sato, Samiratu Mahazu, Isaac Prah, John Addow-Thompson, Mitsuko Ohashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito

PLoS ONE　Vol. 13　No. 12　2018/12　Research paper (scientific journal)

In vitro Mechanistic Assays of Tetracyclic Iridoid Compounds Isolated from Morinda lucida Benth in Leishmania species

Faustus Akankperiwen Azerigyik, Michael Amoa-Bosompem, Thelma Tetteh, Frederick Ayertey, Ama Nyamekye Antwi, Kofi Baffour-Awuah Owusu, Kofi Kwofie Dadzie, Georgina Isabella Djameh, Mark Tetteh-Tsifoanya, Shiro Iwanaga, Alfred Ampomah Appiah, Tomoe Ohta, Takuhiro Uto, Yukihiro Shoyama, Nobuo Ohta, Theresa Manful Gwira, Mitsuko Ohashi

European Journal of Medicinal Plants　Vol. 25　No. 4　p. 1-14　2018/11/14　Research paper (scientific journal)

ガーナ共和国の臨床分離株における薬剤感受性成績

佐藤 和佳菜, Ayibieke Alafate, 小林 あゆみ, 谷 千尋, 齋藤 良一, 鈴木 敏彦, 大橋 光子, 岩永 史朗

首都圏支部・関甲信支部医学検査学会プログラム・講演抄録集　Vol. 55回　p. 131-131　2018/10

CRISPR/Cas9 system in Plasmodium falciparum using the centromere plasmid

Tongchai Payungwoung, Naoaki Shinzawa, Akina Hino, Tubasa Nishi, Yuho Murata, Masao Yuda, Shiroh Iwanaga

Parasitology International　Vol. 67　No. 5　p. 605-608　2018/10　Research paper (scientific journal)

Insights into the mode of action of 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89) against adult Schistosoma mansoni worms

Emmanuel Awusah Blay, Takashi Kumagai, Masafumi Yamabe, Akina Hino, Rieko Shimogawara, Hye Sook Kim, Akira Sato, Koichiro Ichimura, Irene Ayi, Shiroh Iwanaga, Nobuo Ohta

Parasitology International　Vol. 67　No. 4　p. 403-412　2018/08　Research paper (scientific journal)

Morinda lucida含有テトラサイクリックイリドイドの定量分析法の開発

太田 智絵, Tilkanont Tanatorn, Nguyen Huu Tung, Ayertey Frederick, 田上 兼輔, Appiah Ampomah Alfred, Ocloo Augustine, 大橋 光子, 宇都 拓洋, 山口 泰史, 岩永 史郎, 太田 伸生, 正山 征洋

日本薬学会年会要旨集　Vol. 138年会　No. 2　p. 212-212　2018/03

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex

Kofi Dadzie Kwofie, Kai Sato, Chizu Sanjoba, Akina Hino, Rieko Shimogawara, Michael Amoa-Bosompem, Irene Ayi, Daniel A. Boakye, Abraham K. Anang, Kyung Soo Chang, Mitsuko Ohashi, Hye Sook Kim, Nobuo Ohta, Yoshitsugu Matsumoto, Shiroh Iwanaga

PLoS Neglected Tropical Diseases　Vol. 13　No. 3　2018/03　Research paper (scientific journal)

Corrigendum: Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase

Nature　Vol. 554　No. 7693　p. 554-554　2018/02/22　Research paper (scientific journal)

Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging

Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta, Shiroh Iwanaga

Tropical Medicine and Health　Vol. 46　No. 1　2018/01/05　Research paper (scientific journal)

A potent malaria vaccine based on adenovirus with dual modifications at Hexon and pVII

Takayuki Shiratsuchi, Urvashi Rai, Izumi Kaneko, Min Zhang, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji

Vaccine　Vol. 35　No. 50　p. 6990-7000　2017/12/15　Research paper (scientific journal)

Isolation and characterization of a new iflavirus from armigeres spp. Mosquitoes in the Philippines

Daisuke Kobayashi, Haruhiko Isawa, Ryosuke Fujita, Katsunori Murota, Kentaro Itokawa, Yukiko Higa, Yukie Katayama, Toshinori Sasaki, Tetsuya Mizutani, Shiroh Iwanaga, Nobuo Ohta, Arlene Garcia-Bertuso, Kyoko Sawabe

Journal of General Virology　Vol. 98　No. 11　p. 2876-2881　2017/11　Research paper (scientific journal)

Anti-microbial Activities of Selected Ghanaian Medicinal Plants and Four Structurally Similar Anti-protozoan Compounds against Susceptible and Multi-drug Resistant Bacteria

A Antwi, K Owusu, M Amoa-Bosompem, N Williams, F Ayertey, L Akyeh, J Agyapong, T Tetteh, G Djameh, S Botchie, F Azerigyik, A Ablordey, N Tung, T Uto, A Appiah, S Iwanaga, Y Shoyama, N Ohta, B Egyir, M Ohashi

European Journal of Medicinal Plants　Vol. 20　No. 2　p. 1-14　2017/01/10　Research paper (scientific journal)

A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice

Xiangming Li, Jing Huang, Izumi Kaneko, Min Zhang, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji

Expert Review of Vaccines　Vol. 16　No. 1　p. 73-80　2017/01/02　Research paper (scientific journal)

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase

Nature　Vol. 552　No. 7683　p. 101-105　2017　Research paper (scientific journal)

A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein

Min Zhang, Izumi Kaneko, Tiffany Tsao, Robert Mitchell, Elizabeth H. Nardin, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji

Malaria Journal　Vol. 15　No. 1　p. 201-201　2016/04　Research paper (scientific journal)

Global transcriptional repression: An initial and essential step for Plasmodium sexual development

Masao Yuda, Shiroh Iwanaga, Izumi Kaneko, Tomomi Kato

Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 41　p. 12824-12829　2015/10/13　Research paper (scientific journal)

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

Izumi Kaneko, Shiroh Iwanaga, Tomomi Kato, Issei Kobayashi, Masao Yuda

PLoS Pathogens　Vol. 11　No. 5　2015/05/01　Research paper (scientific journal)

Horizontal gene transfer of a vertebrate vasodilatory hormone into ticks

Shiroh Iwanaga, Haruhiko Isawa, Masao Yuda

Nature Communications　Vol. 5　2014/02/21　Research paper (scientific journal)

Experimental cerebral malaria is suppressed by disruption of nucleoside transporter 1 but not purine nucleoside phosphorylase

Mamoru Niikura, Shin Ichi Inoue, Shoichirou Mineo, Yutaroh Yamada, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Fumie Kobayashi

Biochemical and Biophysical Research Communications　Vol. 432　No. 3　p. 504-508　2013/03/15　Research paper (scientific journal)

Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-Forms

Annemarie Voorberg-van der Wel, Anne Marie Zeeman, Sandra M. van Amsterdam, Alexander van den Berg, Els J. Klooster, Shiroh Iwanaga, Chris J. Janse, Geert Jan van Gemert, Robert Sauerwein, Niels Beenhakker, Gerrit Koopman, Alan W. Thomas, Clemens H.M. Kocken

PLoS ONE　Vol. 8　No. 1　2013/01/30　Research paper (scientific journal)

Liver-specific protein 2: A Plasmodium protein exported to the hepatocyte cytoplasm and required for merozoite formation

Yuki Orito, Tomoko Ishino, Shiroh Iwanaga, Izumi Kaneko, Tomomi Kato, Robert Menard, Yasuo Chinzei, Masao Yuda

Molecular Microbiology　Vol. 87　No. 1　p. 66-79　2013/01　Research paper (scientific journal)

Identification of an AP2-family Protein That Is Critical for Malaria Liver Stage Development

Shiroh Iwanaga, Izumi Kaneko, Tomomi Kato, Masao Yuda

PLoS ONE　Vol. 7　No. 11　2012/11/07　Research paper (scientific journal)

A high-coverage artificial chromosome library for the genome-wide screening of drug-resistance genes in malaria parasites

Shiroh Iwanaga, Izumi Kaneko, Masao Yuda

Genome Research　Vol. 22　No. 5　p. 985-992　2012/05　Research paper (scientific journal)

Centromere plasmid: A new genetic tool for the study of Plasmodium falciparum

Shiroh Iwanaga, Tomomi Kato, Izumi Kaneko, Masao Yuda

PLoS ONE　Vol. 7　No. 3　2012/03/30　Research paper (scientific journal)

Functional Identification of the Plasmodium Centromere and Generation of a Plasmodium Artificial Chromosome

Shiroh Iwanaga, Shahid M. Khan, Izumi Kaneko, Zoe Christodoulou, Chris Newbold, Masao Yuda, Chris J. Janse, Andrew P. Waters

Cell Host and Microbe　Vol. 7　No. 3　p. 245-255　2010/03/18　Research paper (scientific journal)

Transcription factor AP2-Sp and its target genes in malarial sporozoites

Masao Yuda, Shiroh Iwanaga, Shuji Shigenobu, Tomomi Kato, Izumi Kaneko

Molecular Microbiology　Vol. 75　No. 4　p. 854-863　2010/02　Research paper (scientific journal)

Identification of a transcription factor in the mosquito-invasive stage of malaria parasites

Masao Yuda, Shiroh Iwanaga, Shuji Shigenobu, Gunnar R. Mair, Chris J. Janse, Andrew P. Waters, Tomomi Kato, Izumi Kaneko

Molecular Microbiology　Vol. 71　No. 6　p. 1402-1414　2009/03　Research paper (scientific journal)

Rapid determination of viral RNA sequences in mosquitoes collected in the field

Yuki Kihara, Tomomitsu Satho, Yuki Eshita, Kouji Sakai, Akira Kotaki, Tomohiko Takasaki, Yupha Rongsriyam, Narumon Komalamisra, Raweewan Srisawat, Parichat Lapcharoen, Suchada Sumroiphon, Shiroh Iwanaga, Hiroshi Ushijima, Daiji Endoh, Takeshi Miyata, Akira Sakata, Nobuhiro Kashige, Fumio Miake, Shuetsu Fukushi, Masayuki Saijo, Ichiro Kurane, Shigeru Morikawa, Tetsuya Mizutani

Journal of Virological Methods　Vol. 146　No. 1-2　p. 372-374　2007/12　Research paper (scientific journal)

Identification and characterization of plasma kallikrein-kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans

Haruhiko Isawa, Yuki Orito, Naruhiro Jingushi, Siroh Iwanaga, Akihiro Morita, Yasuo Chinzei, Masao Yuda

FEBS Journal　Vol. 274　No. 16　p. 4271-4286　2007/08　Research paper (scientific journal)

Proteomic comparison between Japanese Black and Holstein cattle by two-dimensional gel electrophoresis and identification of proteins

H. Ohsaki, M. Okada, S. Sasazaki, T. Hinenoya, T. Sawa, S. Iwanaga, H. Tsuruta, F. Mukai, H. Mannen

Asian-Australasian Journal of Animal Sciences　Vol. 20　No. 5　p. 638-644　2007/05　Research paper (scientific journal)

Identification and characterization of a new kallikrein-kinin system inhibitor from the salivary glands of the malaria vector mosquito Anopheles stephensi

Haruhiko Isawa, Yuki Orito, Shiroh Iwanaga, Naruhiro Jingushi, Akihiro Morita, Yasuo Chinzei, Masao Yuda

Insect Biochemistry and Molecular Biology　Vol. 37　No. 5　p. 466-477　2007/05　Research paper (scientific journal)

Identification and characterization of a collagen-induced platelet aggregation inhibitor, triplatin, from salivary glands of the assassin bug, Triatoma infestans

Akihiro Morita, Haruhiko Isawa, Yuki Orito, Shiroh Iwanaga, Yasuo Chinzei, Masao Yuda

FEBS Journal　Vol. 273　No. 13　p. 2955-2962　2006/07　Research paper (scientific journal)

Aedes albopictusの中腸transcriptomeの解析

久富 祐人, 佐藤 朝光, 岩永 史朗, 伊澤 晴彦, 宮田 健, 鹿志毛 信広, 見明 史雄

日本薬学会年会要旨集　Vol. 126年会　No. 3　p. 70-70　2006/03

A30 Identification and characterization of the platelet aggregation inhibitors from salivary gland of the assassin bug, Triatoma infestans(General presentation,Abstract,The 58th Annual Meeting of the Japan Society of Medical Entomology and Zoology)

Morita A, Isawa H, Orito Y, Iwanaga S, Chinzei Y, Yuda M

Medical Entomology and Zoology　Vol. 57　No. 0　p. 46-46　2006

Contribution of the N-terminal and C-terminal domains of haemaphysalin to inhibition of activation of plasma kallikrein-kinin system

Noriko Kato, Takahide Okayama, Haruhiko Isawa, Masao Yuda, Yasuo Chinzei, Shiroh Iwanaga

Journal of Biochemistry　Vol. 138　No. 3　p. 225-235　2005/09　Research paper (scientific journal)

Identification and characterization of the plasma kallikrein-kinin system inhibitor, haemaphysalin, from hard tick, Haemaphysalis longicornis

Noriko Kato, Shiroh Iwanaga, Takahide Okayama, Haruhiko Isawa, Masao Yuda, Yasuo Chinzei

Thrombosis and Haemostasis　Vol. 93　No. 2　p. 359-367　2005/02　Research paper (scientific journal)

Characterization of the plasma kallikrein-kinin system inhibitor from hard tick, <I>Haemaphysalis longicornis<I>.

Kato Noriko, Iwanaga Siroh, Isawa Haruhiko, Chinzei Yasuo, Yuda Masao

Abstracts for the Annual Meetings of the Japan Society of Medical Entomology and Zoology　Vol. 57　No. 0　p. 64-64　2005

Contribution of conserved Asn residues to the inhibitory activities of kunitz-type protease inhibitors from plants

Shiroh Iwanaga, Nobuyuki Yamasaki, Makoto Kimura, Yoshiaki Kouzuma

Bioscience, Biotechnology and Biochemistry　Vol. 69　No. 1　p. 220-223　2005/01　Research paper (scientific journal)

21 Identification and characterization of contact system inhibitors from the salivary glands of a blood-sucking insect, Triatoma infestans

Isawa H., Yuda M., Orito Y., Jinguji N., Iwanaga S., Katoh N., Chinzei Y.

Medical Entomology and Zoology　Vol. 55　No. 0　p. 42-42　2004

Identification and characterization of novel salivary thrombin inhibitors from the ixodidae tick, Haemaphysalis longicornis

Shiroh Iwanaga, Masakazu Okada, Haruhiko Isawa, Akihiro Morita, Masao Yuda, Yasuo Chinzei

European Journal of Biochemistry　Vol. 270　No. 9　p. 1926-1934　2003/05　Research paper (scientific journal)

Conformation of the primary binding loop folded through an intramolecular interaction contributes to the strong chymotrypsin inhibitory activity of the chymotrypsin inhibitor from Erythrina variegata seeds

Shiroh Iwanaga, Ruby Nagata, Atsushi Miyamoto, Yoshiaki Kouzuma, Nobuyuki Yamasaki, Makoto Kimura

Journal of Biochemistry　Vol. 126　No. 1　p. 162-167　1999　Research paper (scientific journal)

Chymotrypsin inhibitor from Erythrina uariegata seeds: Involvement of amino acid residues within the primary binding loop in potent inhibitory activity toward chymotrypsin

Shiroh Iwanaga, Nobuyuki Yamasaki, Makoto Kimura

Journal of Biochemistry　Vol. 124　No. 3　p. 663-669　1998/09　Research paper (scientific journal)

Analysis of the complex formed by Erythrina variegata chymotrypsin inhibitor with chymotrypsin and properties of the peptides prepared from the inhibitor by a limited proteolysis

Makoto Kimura, Nao Harada, Shiroh Iwanaga, Nobuyuki Yamasaki

European Journal of Biochemistry　Vol. 249　No. 3　p. 870-877　1997　Research paper (scientific journal)

Carsberg Res. Commun. Carsberg Res. Commun. 48, 81-94, 1983

KURAMITSU, Jun-ichi, IWANAGA, Shiroh, YAMASAKI, Nobuyuki, KIMURA, Makoto

Bioscience, biotechnology, and biochemistry　Vol. 60　No. 9　p. 1469-1473　1996　Research paper (scientific journal)

Effects of hmolecular cloning of cDNA that encodes chymotrypsin inhibitor ECI from erythrina variegata seeds and its expression in escherichia coli

Jun Ichi Kuramitsu, Shiroh Iwanaga, Nobuyuki Yamasaki, Makoto Kimura

Bioscience, Biotechnology and Biochemistry　Vol. 60　No. 9　p. 1469-1473　1996/01　Research paper (scientific journal)

The Structure of the Ribosomal Protein Gene in M. bovis BCG

Kimura, M., Iwanaga, S.

RADIOISOTOPES　Vol. 44　p. 79-79　1995　Research paper (scientific journal)

Cloning and nucleotide sequence of the gene cluster encoding ribosomal proteins S12 and S7 from Mycobacterium bovis BCG

S. Iwanaga, N. Ohara, T. Kariu, M. Kimura, N. Yamasaki, T. Yamada

Biochemistry and Molecular Biology International　Vol. 36　No. 1　p. 209-218　1995　Research paper (scientific journal)

Production, purification, and characterization of botulinolysin, a thiol- activated hemolysin of Clostridium botulinum

A. Haque, N. Sugimoto, Y. Horiguchi, T. Okabe, T. Miyata, S. Iwanaga, M. Matsuda

Infection and Immunity　Vol. 60　No. 1　p. 71-78　1992　Research paper (scientific journal)